David Donner, PhD

Title(s)Professor, Surgery
SchoolSchool of Medicine
Address1600 Divisadero
San Francisco CA 94115
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    Collapse Research 
    Collapse Research Activities and Funding
    NIH/NCI R01CA073023Sep 1, 1997 - Jun 30, 2004
    Role: Principal Investigator
    Tumor Necrosis Factor Action in Cells
    NIH/NCI R01CA067891Feb 1, 1997 - Mar 31, 2006
    Role: Principal Investigator
    NIH/NCI R55CA067891Sep 6, 1996 - Jan 31, 1997
    Role: Principal Investigator
    NIH/NCI R01CA044747Mar 1, 1988 - Feb 28, 1994
    Role: Principal Investigator
    NIH/NIADDK K04AM001045Jul 1, 1982 - Jun 30, 1987
    Role: Principal Investigator
    NIH/NIDDK K04DK001045Jul 1, 1982 - Jun 30, 1987
    Role: Principal Investigator
    NIH/NIDDK R01DK030788May 1, 1982 - Apr 30, 1990
    Role: Principal Investigator
    NIH/NIADDK R01AM030788May 1, 1982 - Aug 31, 1985
    Role: Principal Investigator
    NIH/NIADDK R01AM022121Sep 15, 1978 - Apr 30, 1986
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Patient-derived organoids for personalized drug screening in intrahepatic cholangiocarcinoma. Journal of Clinical Oncology. 2020 Feb 1; 38(4_suppl):581-581. Ricardo J. Antonia, Kan Toriguchi, Eveliina Karelehto, Dania Annuar, Luika Timmerman, Noura Tbeileh, Aras N. Mattis, Carlos U. Corvera, Kenzo Hirose, Eric K. Nakakura, David B. Donner, Robert S. Warren. .
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    2. High thymidylate synthase gene expression predicts poor outcome after resection of hepatocellular carcinoma. PLoS One. 2019; 14(7):e0219469. Donner DB, Nakakura EK, Venook AP, Lenz HJ, Zhang W, Hwang J, Bergsland EK, Lin MH, Toriguchi K, Antonia RJ, Warren RS. PMID: 31291332.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Mitogen Inducible Gene-6 Is a Prognostic Marker for Patients with Colorectal Liver Metastases. Transl Oncol. 2019 Mar; 12(3):550-560. Donner DB, Ruan DT, Toriguchi K, Bergsland EK, Nakakura EK, Lin MH, Antonia RJ, Warren RS. PMID: 30639964.
      View in: PubMed   Mentions:
    4. A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors. . 2018 12; 17(12):2702-2709. Chamberlain CE, German MS, Yang K, Wang J, VanBrocklin H, Regan M, Shokat KM, Ducker GS, Kim GE, Hann B, Donner DB, Warren RS, Venook AP, Bergsland EK, Lee D, Wang Y, Nakakura EK. PMID: 30254185.
      View in: PubMed   Mentions:
    5. An approach to patient-specific treatment of intrahepatic cholangiocarcinoma (ICC): drug screens with patient-derived spheroids identify mTOR as a viable and druggable target. Hepato Pancreato Biliary. 2018 Sep 1; 20:s690-s691. K. Toriguchi, M. Lin, E. Nakakura, C. Corvera, B. Hann, D. Donner, R. Warren. .
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    6. Sentinel Node in Oral Cancer: The Nuclear Medicine Aspects. A Survey from the Sentinel European Node Trial. Clin Nucl Med. 2016 Jul; 41(7):534-42. Tartaglione G, Stoeckli SJ, de Bree R, Schilling C, Flach GB, Bakholdt V, Sorensen JA, Bilde A, von Buchwald C, Lawson G, Dequanter D, Villarreal PM, Forcelledo MF, Amezaga JA, Moreira A, Poli T, Grandi C, Vigili MG, O'Doherty M, Donner D, Bloemena E, Rahimi S, Gurney B, Haerle SK, Broglie MA, Huber GF, Krogdah AL, Sebbesen LR, Odell E, Junquera Gutierrez LM, Barbier L, Santamaria-Zuazua J, Jacome M, Nollevaux MC, Bragantini E, Lothaire P, Silini EM, Sesenna E, Dolivet G, Mastronicola R, Leroux A, Sassoon I, Sloan P, Colletti PM, Rubello D, McGurk M. PMID: 27088386.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    7. Serial 18F-choline-PET imaging in patients receiving enzalutamide for metastatic castration-resistant prostate cancer: response assessment and imaging biomarkers. Future Oncol. 2016 Feb; 12(3):333-42. Maines F, Caffo O, Donner D, Sperduti I, Bria E, Veccia A, Chierichetti F, Tortora G, Galligioni E. PMID: 26768648.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    8. Sentinel European Node Trial (SENT): 3-year results of sentinel node biopsy in oral cancer. Eur J Cancer. 2015 Dec; 51(18):2777-84. Schilling C, Stoeckli SJ, Haerle SK, Broglie MA, Huber GF, Sorensen JA, Bakholdt V, Krogdahl A, von Buchwald C, Bilde A, Sebbesen LR, Odell E, Gurney B, O'Doherty M, de Bree R, Bloemena E, Flach GB, Villarreal PM, Fresno Forcelledo MF, Junquera Gutiérrez LM, Amézaga JA, Barbier L, Santamaría-Zuazua J, Moreira A, Jacome M, Vigili MG, Rahimi S, Tartaglione G, Lawson G, Nollevaux MC, Grandi C, Donner D, Bragantini E, Dequanter D, Lothaire P, Poli T, Silini EM, Sesenna E, Dolivet G, Mastronicola R, Leroux A, Sassoon I, Sloan P, McGurk M. PMID: 26597442.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    9. RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth. Nat Cell Biol. 2015 Jun; 17(6):804-15. Depeille P, Henricks LM, van de Ven RA, Lemmens E, Wang CY, Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP. PMID: 26005835.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    10. Wild type p53 transcriptionally represses the SALL2 transcription factor under genotoxic stress. PLoS One. 2013; 8(9):e73817. Farkas C, Martins CP, Escobar D, Hepp MI, Castro AF, Evan G, Gutiérrez JL, Warren R, Donner DB, Pincheira R. PMID: 24040083.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. Association of TP53 mutational status and gender with survival after adjuvant treatment for stage III colon cancer: results of CALGB 89803. Clin Cancer Res. 2013 Oct 15; 19(20):5777-87. Warren RS, Atreya CE, Niedzwiecki D, Weinberg VK, Donner DB, Mayer RJ, Goldberg RM, Compton CC, Zuraek MB, Ye C, Saltz LB, Bertagnolli MM. PMID: 23983256.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    12. Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors. Oncogene. 2014 Mar 20; 33(12):1590-600. Ducker GS, Atreya CE, Simko JP, Hom YK, Matli MR, Benes CH, Hann B, Nakakura EK, Bergsland EK, Donner DB, Settleman J, Shokat KM, Warren RS. PMID: 23542178.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    13. The endemic paraganglioma syndrome type 1: origin, spread, and clinical expression. J Clin Endocrinol Metab. 2012 Apr; 97(4):E637-41. Schiavi F, Demattè S, Cecchini ME, Taschin E, Bobisse S, Del Piano A, Donner D, Barbareschi M, Manera V, Zovato S, Erlic Z, Savvoukidis T, Barollo S, Grego F, Trabalzini F, Amistà P, Grandi C, Branz F, Marroni F, Neumann HP, Opocher G. PMID: 22456618.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansPHPublic Health
    14. Effect of PIK3CA and KRAS mutations on sensitivity to ATP-competitive mTOR inhibitors in a primary xenograft model of colorectal carcinoma. Journal of Clinical Oncology. 2012 Feb 1; 30(4_suppl):483-483. Gregory S. Ducker, Chloe Evelyn Atreya, Jeffrey Simko, Eric K. Nakakura, Emily K. Bergsland, David B. Donner, Kevan M. Shokat, Robert S. Warren. .
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    15. Thyroid-specific knockout of the tumor suppressor mitogen-inducible gene 6 activates epidermal growth factor receptor signaling pathways and suppresses nuclear factor-κB activity. Surgery. 2011 Dec; 150(6):1295-302. Lin CI, Barletta JA, Nehs MA, Morris ZS, Donner DB, Whang EE, Jeong JW, Kimura S, Moore FD, Ruan DT. PMID: 22136853.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    16. CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET). J Biol Chem. 2011 May 20; 286(20):17543-59. Mitra R, Guo Z, Milani M, Mesaros C, Rodriguez M, Nguyen J, Luo X, Clarke D, Lamba J, Schuetz E, Donner DB, Puli N, Falck JR, Capdevila J, Gupta K, Blair IA, Potter DA. PMID: 21402692.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    17. A Primary Xenograft Model of Pancreatic Neuroendocrine Carcinoma Maintains a Neuroendocrine Tumor Gene Expression Signature. Journal of Surgical Research. 2011 Feb 1; 165(2):296. Y. Wang, D. Donner, A. Venook, E. Bergsland, R. Warren, E. Nakakura. .
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    18. Mitogen-Inducible Gene-6 Is a Multifunctional Adaptor Protein with Tumor Suppressor-Like Activity in Papillary Thyroid Cancer. Endocrinology. 2011 Feb 1; 25(2):373-373. Chi-Iou Lin, Jinyan Du, Wen Shen, Edward E. Whang, David B. Donner, Nick Griff, Frank He, Francis D. Moore, Orlo H. Clark, Daniel T. Ruan. .
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    19. Mitogen-Inducible Gene-6 Is a Multifunctional Adaptor Protein with Tumor Suppressor-Like Activity in Papillary Thyroid Cancer. Endocrine Reviews. 2011 Feb 1; 32(1):157-158. Chi-Iou Lin, Jinyan Du, Wen Shen, Edward E. Whang, David B. Donner, Nick Griff, Frank He, Francis D. Moore, Orlo H. Clark, Daniel T. Ruan. .
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    20. Mitogen-inducible gene-6 is a multifunctional adaptor protein with tumor suppressor-like activity in papillary thyroid cancer. J Clin Endocrinol Metab. 2011 Mar; 96(3):E554-65. Lin CI, Du J, Shen WT, Whang EE, Donner DB, Griff N, He F, Moore FD, Clark OH, Ruan DT. PMID: 21190978.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    21. Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer. Mol Cancer Res. 2010 Sep; 8(9):1217-26. Lin CI, Whang EE, Donner DB, Du J, Lorch J, He F, Jiang X, Price BD, Moore FD, Ruan DT. PMID: 20736296.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    22. Lack of NKX2.2 expression in bronchopulmonary typical carcinoid tumors: implications for patients with neuroendocrine tumor metastases and unknown primary site. J Surg Res. 2010 Sep; 163(1):47-51. Wang YC, Iezza G, Zuraek MB, Jablons DM, Theodore PR, Bergsland EK, Donner DB, Warren RS, Nakakura EK. PMID: 20599218.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Distinct mTOR Pathway Activity in Neuroendocrine Tumors of the Pancreas and Small Intestine Revealed by Immunohistochemical Analysis. Pancreas. 2010 Mar 1; 39(2):276. Eric Nakakura, Melissa Wong, Yucheng Wang, Gioia Iezza, Marlene Zuraek, Xiaochen Yuan, David Donner, Douglas Hanahan, Robert Warren, Emily Bergsland. .
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    24. The ETS oncogene family transcription factor FEV identifies serotonin-producing cells in normal and neoplastic small intestine. Endocr Relat Cancer. 2010 Mar; 17(1):283-91. Wang YC, Zuraek MB, Kosaka Y, Ota Y, German MS, Deneris ES, Bergsland EK, Donner DB, Warren RS, Nakakura EK. PMID: 20048018.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    25. Lack of NKX2.2 Transcription Factor Expression Distinguishes Bronchopulmonary Typical Carcinoids from Gastrointestinal Neuroendocrine Tumors. Journal of Surgical Research. 2010 Feb 1; 158(2):267. E.K. Nakakura, G. Iezza, M. Zuraek, D. Jablons, P. Theodore, D. Donner, E. Bergsland, R. Warren, Y. Wang. .
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    26. Reduced GFI1 Transcription Factor Expression in Small Intestinal Neuroendocrine Tumor Metastases. Journal of Surgical Research. 2010 Feb 1; 158(2):266-267. E.K. Nakakura, M. Zuraek, D. Donner, E. Bergsland, R. Warren, Y. Wang. .
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    27. Autophagy: a new target for advanced papillary thyroid cancer therapy. Surgery. 2009 Dec; 146(6):1208-14. Lin CI, Whang EE, Abramson MA, Jiang X, Price BD, Donner DB, Moore FD, Ruan DT. PMID: 19958950.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    28. Galectin-3 targeted therapy with a small molecule inhibitor activates apoptosis and enhances both chemosensitivity and radiosensitivity in papillary thyroid cancer. Mol Cancer Res. 2009 Oct; 7(10):1655-62. Lin CI, Whang EE, Donner DB, Jiang X, Price BD, Carothers AM, Delaine T, Leffler H, Nilsson UJ, Nose V, Moore FD, Ruan DT. PMID: 19825987.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    29. Tissue transglutaminase regulates matrix metalloproteinase-2 in ovarian cancer by modulating cAMP-response element-binding protein activity. J Biol Chem. 2009 Jun 05; 284(23):15390-9. Satpathy M, Shao M, Emerson R, Donner DB, Matei D. PMID: 19324884.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    30. QS138. The FEV Transcription Factor is Abberantly Expressed in Neuroendocrine Tumors of the Small Intestine. Journal of Surgical Research. 2009 Feb 1; 151(2):288. Y. Wang, M. Zuraek, D. Donner, E. Bergsland, R. Warren, E.K. Nakakura. .
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    31. Clinical considerations on sentinel node biopsy in melanoma from an Italian multicentric study on 1,313 patients (SOLISM-IMI). Ann Surg Oncol. 2009 Jul; 16(7):2018-27. Testori A, De Salvo GL, Montesco MC, Trifirò G, Mocellin S, Landi G, Macripò G, Carcoforo P, Ricotti G, Giudice G, Picciotto F, Donner D, Di Filippo F, Soteldo J, Casara D, Schiavon M, Vecchiato A, Pasquali S, Baldini F, Mazzarol G, Rossi CR. PMID: 19132446.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCTClinical Trials
    32. Sall2 is a novel p75NTR-interacting protein that links NGF signalling to cell cycle progression and neurite outgrowth. EMBO J. 2009 Feb 04; 28(3):261-73. Pincheira R, Baerwald M, Dunbar JD, Donner DB. PMID: 19131967.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    33. Galectin-3 regulates apoptosis and doxorubicin chemoresistance in papillary thyroid cancer cells. Biochem Biophys Res Commun. 2009 Feb 06; 379(2):626-31. Lin CI, Whang EE, Abramson MA, Donner DB, Bertagnolli MM, Moore FD, Ruan DT. PMID: 19124005.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    34. Mitogen-inducible gene-6 expression correlates with survival and is an independent predictor of recurrence in BRAF(V600E) positive papillary thyroid cancers. Surgery. 2008 Dec; 144(6):908-13; discussion 913-4. Ruan DT, Warren RS, Moalem J, Chung KW, Griffin AC, Shen W, Duh QY, Nakakura E, Donner DB, Khanafshar E, Weng J, Clark OH, Kebebew E. PMID: 19040996.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    35. Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors. Endocr Relat Cancer. 2009 Mar; 16(1):267-79. Wang YC, Gallego-Arteche E, Iezza G, Yuan X, Matli MR, Choo SP, Zuraek MB, Gogia R, Lynn FC, German MS, Bergsland EK, Donner DB, Warren RS, Nakakura EK. PMID: 18987169.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    36. The Sall2 transcription factor is a novel p75NTR binding protein that promotes the development and function of neurons. Ann N Y Acad Sci. 2008 Nov; 1144:53-5. Pincheira R, Donner DB. PMID: 19076363.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    37. Type 1 TNF receptor forms a complex with and uses Jak2 and c-Src to selectively engage signaling pathways that regulate transcription factor activity. J Immunol. 2008 Jul 15; 181(2):1288-98. Pincheira R, Castro AF, Ozes ON, Idumalla PS, Donner DB. PMID: 18606683.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    38. Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1alpha and Hdm2. Cancer Res. 2007 Jan 15; 67(2):450-4. LaRusch GA, Jackson MW, Dunbar JD, Warren RS, Donner DB, Mayo LD. PMID: 17234751.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    39. The platelet-derived growth factor receptor alpha is destabilized by geldanamycins in cancer cells. J Biol Chem. 2007 Jan 05; 282(1):445-53. Matei D, Satpathy M, Cao L, Lai YC, Nakshatri H, Donner DB. PMID: 17079230.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    40. Hdm2 nuclear export, regulated by insulin-like growth factor-I/MAPK/p90Rsk signaling, mediates the transformation of human cells. J Biol Chem. 2006 Jun 16; 281(24):16814-20. Jackson MW, Patt LE, LaRusch GA, Donner DB, Stark GR, Mayo LD. PMID: 16621805.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    41. Akt regulates basal and induced processing of NF-kappaB2 (p100) to p52. J Biol Chem. 2006 Jun 16; 281(24):16473-81. Gustin JA, Korgaonkar CK, Pincheira R, Li Q, Donner DB. PMID: 16613850.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    42. p53 regulates Btk-dependent B cell proliferation but not differentiation. J Leukoc Biol. 2006 Apr; 79(4):852-9. Schmidt NW, Mayo LD, Donner DB, Kaplan MH. PMID: 16461747.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    43. PDGFR is activated through an autocrine mechanism in ovarian cancer. Journal of Clinical Oncology. 2005 Jun 1; 23(16_suppl):5073-5073. D. Matei, Y.-C. Lai, J. Rao, R. Emerson, D. Donner. .
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    44. Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified. J Biol Chem. 2005 Jul 15; 280(28):25953-9. Mayo LD, Seo YR, Jackson MW, Smith ML, Rivera Guzman J, Korgaonkar CK, Donner DB. PMID: 15843377.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    45. Tumor Necrosis Factor-a/Receptor Signaling Through the Akt Kinase. Cell Signaling in Vascular Inflammation. 2005 Jan 1; 13-22. Osman Nidai Ozes, Hakan Akca, Jason A. Gustin, Lindsey D. Mayo, Roxana Pincheira, Chandrashekhar K. Korgaonkar, David B. Donner. .
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    46. Expression of human papillomavirus type 16 E6 and E7 oncoproteins in primary foreskin keratinocytes is sufficient to alter the expression of angiogenic factors. Oncogene. 2004 Apr 15; 23(17):2988-95. Toussaint-Smith E, Donner DB, Roman A. PMID: 14968115.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    47. Tumor necrosis factor activates CRE-binding protein through a p38 MAPK/MSK1 signaling pathway in endothelial cells. . 2004 Mar; 286(3):C547-55. Gustin JA, Pincheira R, Mayo LD, Ozes ON, Kessler KM, Baerwald MR, Korgaonkar CK, Donner DB. PMID: 14761884.
      View in: PubMed   Mentions:
    48. Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation. J Biol Chem. 2004 Jan 16; 279(3):1615-20. Gustin JA, Ozes ON, Akca H, Pincheira R, Mayo LD, Li Q, Guzman JR, Korgaonkar CK, Donner DB. PMID: 14585846.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    49. PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment. Cancer Res. 2003 Jul 01; 63(13):3585-92. Su JD, Mayo LD, Donner DB, Durden DL. PMID: 12839945.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    50. The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network. Trends Biochem Sci. 2002 Sep; 27(9):462-7. Mayo LD, Donner DB. PMID: 12217521.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    51. Expression and endocytosis of VEGF and its receptors in human colonic vascular endothelial cells. Am J Physiol Gastrointest Liver Physiol. 2002 Jun; 282(6):G1088-96. Wang D, Lehman RE, Donner DB, Matli MR, Warren RS, Welton ML. PMID: 12016135.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    52. PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy. J Biol Chem. 2002 Feb 15; 277(7):5484-9. Mayo LD, Dixon JE, Durden DL, Tonks NK, Donner DB. PMID: 11729185.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansCells
    53. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11598-603. Mayo LD, Donner DB. PMID: 11504915.
      View in: PubMed   Mentions: 338     Fields:    Translation:HumansCells
    54. The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity. J Biol Chem. 2001 Jul 20; 276(29):27740-4. Gustin JA, Maehama T, Dixon JE, Donner DB. PMID: 11356844.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    55. Vascular endothelial cell growth factor activates CRE-binding protein by signaling through the KDR receptor tyrosine kinase. J Biol Chem. 2001 Jul 06; 276(27):25184-9. Mayo LD, Kessler KM, Pincheira R, Warren RS, Donner DB. PMID: 11335727.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    56. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4640-5. Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, Donner DB. PMID: 11287630.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansCells
    57. Interferon alpha /beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt. J Biol Chem. 2001 Apr 27; 276(17):13756-61. Yang CH, Murti A, Pfeffer SR, Kim JG, Donner DB, Pfeffer LM. PMID: 11278812.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    58. reply: Kinase regulation in inflammatory response. Nature. 2000 Jul 1; 406(6794):368-368. Osman Nidai Ozes, Lindsey D. Mayo, Jason A. Gustin, Susan R. Pfeffer, Lawrence M. Pfeffer, David B. Donner. .
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    59. Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the vascular endothelial cell growth factor (VEGF) receptor mRNAs by VEGF. J Biol Chem. 2000 May 26; 275(21):15905-11. Wang D, Donner DB, Warren RS. PMID: 10748050.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    60. Tumor necrosis factor employs a protein-tyrosine phosphatase to inhibit activation of KDR and vascular endothelial cell growth factor-induced endothelial cell proliferation. J Biol Chem. 2000 Apr 14; 275(15):11216-21. Guo DQ, Wu LW, Dunbar JD, Ozes ON, Mayo LD, Kessler KM, Gustin JA, Baerwald MR, Jaffe EA, Warren RS, Donner DB. PMID: 10753929.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    61. VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor. J Biol Chem. 2000 Mar 03; 275(9):6059-62. Wu LW, Mayo LD, Dunbar JD, Kessler KM, Ozes ON, Warren RS, Donner DB. PMID: 10692392.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    62. Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation. J Biol Chem. 2000 Feb 18; 275(7):5096-103. Wu LW, Mayo LD, Dunbar JD, Kessler KM, Baerwald MR, Jaffe EA, Wang D, Warren RS, Donner DB. PMID: 10671553.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    63. Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB. Mol Cell Biol. 1999 Oct; 19(10):6500-8. Pazdernik NJ, Donner DB, Goebl MG, Harrington MA. PMID: 10490590.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    64. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature. 1999 Sep 02; 401(6748):82-5. Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB. PMID: 10485710.
      View in: PubMed   Mentions: 534     Fields:    Translation:HumansAnimalsCells
    65. Modulation of tumor necrosis factor and interleukin-1-dependent NF-kappaB activity by mPLK/IRAK. J Biol Chem. 1999 May 07; 274(19):13077-84. Vig E, Green M, Liu Y, Donner DB, Mukaida N, Goebl MG, Harrington MA. PMID: 10224059.
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    66. The proteasome regulates caspase-dependent and caspase-independent protease cascades during apoptosis of MO7e hematopoietic progenitor cells. Blood Cells Mol Dis. 1999 Feb; 25(1):20-9. Wu LW, Reid S, Ritchie A, Broxmeyer HE, Donner DB. PMID: 10349510.
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    67. Coordinated induction of VEGF receptors in mesenchymal cell types during rat hepatic wound healing. Oncogene. 1998 Jul 09; 17(1):115-21. Ankoma-Sey V, Matli M, Chang KB, Lalazar A, Donner DB, Wong L, Warren RS, Friedman SL. PMID: 9671320.
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    68. Induction of Jak/STAT signaling by activation of the type 1 TNF receptor. J Immunol. 1998 Mar 15; 160(6):2742-50. Guo D, Dunbar JD, Yang CH, Pfeffer LM, Donner DB. PMID: 9510175.
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    69. Two-hybrid cloning of a gene encoding TNF receptor-associated protein 2, a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease. J Immunol. 1997 May 01; 158(9):4252-9. Dunbar JD, Song HY, Guo D, Wu LW, Donner DB. PMID: 9126987.
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    70. Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma. J Biol Chem. 1996 Nov 15; 271(46):29483-8. Warren RS, Yuan H, Matli MR, Ferrara N, Donner DB. PMID: 8910616.
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    71. Inhibition of tumor necrosis factor signal transduction in endothelial cells by dimethylaminopurine. J Biol Chem. 1996 Nov 08; 271(45):28624-9. Marino MW, Dunbar JD, Wu LW, Ngaiza JR, Han HM, Guo D, Matsushita M, Nairn AC, Zhang Y, Kolesnick R, Jaffe EA, Donner DB. PMID: 8910494.
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    72. Macrophage-stimulating protein, a ligand for the RON receptor protein tyrosine kinase, suppresses myeloid progenitor cell proliferation and synergizes with vascular endothelial cell growth factor and members of the chemokine family. Ann Hematol. 1996 Jul; 73(1):1-9. Broxmeyer HE, Cooper S, Li ZH, Lu L, Sarris A, Wang MH, Chang MS, Donner DB, Leonard EJ. PMID: 8695717.
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    73. Tumor necrosis factor promotes phosphorylation and binding of insulin receptor substrate 1 to phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. J Biol Chem. 1996 Jan 12; 271(2):615-8. Guo D, Donner DB. PMID: 8557661.
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    74. Myeloid progenitor cell regulatory effects of vascular endothelial cell growth factor. Int J Hematol. 1995 Dec; 62(4):203-15. Broxmeyer HE, Cooper S, Li ZH, Lu L, Song HY, Kwon BS, Warren RE, Donner DB. PMID: 8589366.
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    75. Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor. Biochem J. 1995 Aug 01; 309 ( Pt 3):825-9. Song HY, Donner DB. PMID: 7639698.
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    76. Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation. J Biol Chem. 1995 Mar 24; 270(12):6729-33. Guo D, Jia Q, Song HY, Warren RS, Donner DB. PMID: 7896817.
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    77. Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor. J Biol Chem. 1995 Feb 24; 270(8):3574-81. Song HY, Dunbar JD, Zhang YX, Guo D, Donner DB. PMID: 7876093.
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    78. Aggregation of the intracellular domain of the type 1 tumor necrosis factor receptor defined by the two-hybrid system. J Biol Chem. 1994 Sep 09; 269(36):22492-5. Song HY, Dunbar JD, Donner DB. PMID: 8077196.
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    79. Acute metabolic effects of human recombinant tumor necrosis factor beta in the rat. Ann Surg Oncol. 1994 Sep; 1(5):373-7. Blumberg D, Tsuburaya A, Burt M, Donner DB, Brennan MF. PMID: 7850538.
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    80. Human insulin receptor mutated at threonine 1336 functions normally in Chinese hamster ovary cells. J Biol Chem. 1993 Aug 05; 268(22):16839-44. Ahn J, Rosen OM, Donner DB. PMID: 8393875.
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    81. Identification of a new receptor subtype for tumor necrosis factor-alpha. J Biol Chem. 1993 May 15; 268(14):9949-52. Schwalb DM, Han HM, Marino M, Warren R, Porter A, Goh C, Fair WR, Donner DB. PMID: 7683686.
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    82. Interaction of the human insulin receptor tyrosine kinase from the baculovirus expression system with protein kinase C in a cell-free system. J Biol Chem. 1993 Apr 05; 268(10):7571-6. Ahn J, Donner DB, Rosen OM. PMID: 8463287.
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    83. Tumour necrosis factor-induced cytotoxicity is accompanied by intracellular mitogenic signals in ME-180 human cervical carcinoma cells. Biochem J. 1993 Feb 15; 290 ( Pt 1):185-90. Manchester KM, Heston WD, Donner DB. PMID: 8439287.
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    84. Identification and characterization of receptors for tumor necrosis factor-alpha in the brain. Biochem Biophys Res Commun. 1991 Dec 31; 181(3):1532-8. Kinouchi K, Brown G, Pasternak G, Donner DB. PMID: 1662500.
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    85. Phosphorylation of the proto-oncogene product eukaryotic initiation factor 4E is a common cellular response to tumor necrosis factor. J Biol Chem. 1991 Feb 15; 266(5):2685-8. Marino MW, Feld LJ, Jaffe EA, Pfeffer LM, Han HM, Donner DB. PMID: 1993647.
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    86. Identification, characterization, and homologous up-regulation of latent (cryptic) receptors for tumor necrosis factor-alpha in rat liver plasma membranes. J Biol Chem. 1990 Oct 25; 265(30):18590-4. Han HM, Kolhatkar AA, Marino MW, Manchester KM, Donner DB. PMID: 2170416.
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    87. The down-regulation of alpha-interferon receptors in human lymphoblastoid cells: relation to cellular responsiveness to the antiproliferative action of alpha-interferon. Cancer Res. 1990 May 01; 50(9):2654-7. Pfeffer LM, Donner DB. PMID: 2139358.
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    88. Mediation of anorexia by human recombinant tumor necrosis factor through a peripheral action in the rat. Cancer Res. 1989 Nov 15; 49(22):6280-4. Bodnar RJ, Pasternak GW, Mann PE, Paul D, Warren R, Donner DB. PMID: 2804974.
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    89. Tumor necrosis factor induces phosphorylation of a 28-kDa mRNA cap-binding protein in human cervical carcinoma cells. Proc Natl Acad Sci U S A. 1989 Nov; 86(21):8417-21. Marino MW, Pfeffer LM, Guidon PT, Donner DB. PMID: 2813400.
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    90. Insulin stimulates proteolysis of the alpha-subunit, but not the beta-subunit, of its receptor at the cell surface in rat liver. Biochem J. 1989 Jul 15; 261(2):333-40. Lipson KE, Kolhatkar AA, Donner DB. PMID: 2673219.
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    91. Alkylation, reduction, solubilization and enrichment of binding activity do not impair the ability of insulin receptors to convert from a rapid- into a slow-dissociating state. Biochem J. 1989 May 01; 259(3):871-8. Lipson KE, Kolhatkar AA, Donner DB. PMID: 2658980.
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    92. Increased epidermal growth factor receptor in multidrug-resistant human neuroblastoma cells. J Cell Biochem. 1988 Oct; 38(2):87-97. Meyers MB, Shen WP, Spengler BA, Ciccarone V, O'Brien JP, Donner DB, Furth ME, Biedler JL. PMID: 2464605.
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    93. Cell surface proteolysis and down-regulation of the hepatic insulin receptor. Evidence for selective sorting of intact and degraded receptors after internalization. J Biol Chem. 1988 Jul 25; 263(21):10495-501. Lipson KE, Kolhatkar AA, Donner DB. PMID: 3292527.
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    94. Divalent cations regulate glucagon binding. Evidence for actions on receptor-Ns complexes and on receptors uncoupled from Ns. Biochemistry. 1988 Feb 23; 27(4):1111-6. Lipson KE, Kolhatkar AA, Maki RG, Donner DB. PMID: 2835083.
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    95. Modulation of endogenous hormone action by recombinant human tumor necrosis factor. Proc Natl Acad Sci U S A. 1987 Dec; 84(23):8619-22. Warren RS, Donner DB, Starnes HF, Brennan MF. PMID: 2825198.
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    96. Structure and proteolysis of the growth hormone receptor on rat hepatocytes. Biochemistry. 1987 Jul 14; 26(14):4438-43. Yamada K, Lipson KE, Donner DB. PMID: 3478092.
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    97. Early Events in the Interaction of IFN-a with IFN-Sensitive and IFN-Resistant Daudi Cells. The Biology of the Interferon System 1986. 1987 Jan 1; 99-105. Lawrence M. Pfeffer, David B. Donner, Tsutomu Arakawa, Nowell Stebbing, Igor Tamm. .
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    98. Structural Studies of the Growth Hormone Receptor by Affinity Labeling. Human Growth Hormone. 1986 Jan 1; 463-473. David B. Donner, Kazuyo Yamada, Kenneth E. Lipson, Andrea Dorato. .
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    99. Evidence that non-covalent forces, thiol and disulphide groups affect the structure and binding properties of the prolactin receptor on hepatocytes from pregnant rats. Biochem J. 1985 Jun 01; 228(2):383-90. Yamada K, Donner DB. PMID: 2990446.
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    100. Structures of the somatotropin receptor and prolactin receptor on rat hepatocytes characterized by affinity labelling. Biochem J. 1984 Jun 01; 220(2):361-9. Yamada K, Donner DB. PMID: 6331415.
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    101. Insulin binding to liver plasma membranes from rats rendered diabetic by alloxan. A kinetic demonstration of two classes of binding sites in equilibrium with each other. Biochem J. 1982 Jan 15; 202(1):259-62. Corin RE, Donner DB. PMID: 7044376.
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    102. BINDING, INTERNALIZATION, AND DEGRADATION OF 125I-INSULIN BY CULTURED RAT PITUITARY TUMOR CELLS. Cellular Responses to Molecular Modulators. 1981 Jan 1; 504. Robert E. Corin, F.C. Bancroft, David B. Donner. .
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    103. Interconversion between different states of affinity of the human growth hormone receptor on rat hepatocytes: effects of fractional site occupancy on receptor availability. Biochemistry. 1980 Jul 08; 19(14):3300-6. Donner DB. PMID: 6250563.
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    104. Characterization of the slowly dissociable human growth hormone binding component of isolated rat hepatocytes. Biochemistry. 1980 Jul 08; 19(14):3293-300. Donner DB, Casadei J, Hartstein L, Martin D, Sonenberg M. PMID: 6250562.
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    105. Half-of-the-sites reactivity of the membrane-bound Electrophorus electricus acetylcholine receptor. Biochem Biophys Res Commun. 1974 Oct 08; 60(3):1072-80. Fu JL, Donner DB, Hess GP. PMID: 4429562.
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