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David Jablons, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentSurgery
Address1600 Divisadero
San Francisco CA 94115
Phone415-353-7502
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    Collapse Biography 
    Collapse Awards and Honors
    University of California, San Francisco 1999Surgical Resident Teaching Award
    University of California, San Francisco2001Surgical Resident Teaching Award

    Collapse Overview 
    Collapse Overview
    David M. Jablons M.D., FACS is Professor and Chief of the Section of General Thoracic Surgery at UCSF, and Program Leader of Thoracic Oncology. Dr. Jablons is also Ada Distinguished Professor in Thoracic Oncology and Nan T. McEvoy Distinguished Professor of Thoracic Surgical Oncology. Dr. Jablons is Director of the Thoracic Oncology Lab, one of the largest in the Department of Surgery, with seven principal investigators, an enviable portfolio of NIH grants, and state-of-art-equipment. Utilizing next generation sequencing and leveraging one of the largest thoracic tissue banks in the world, the lab has compiled an enviable record of scientific discovery and invention including a life-saving prognostic assay that informs the decision for providing adjuvant therapy to early-stage lung cancer patients.

    Dr. Jablons received his medical degree from Albany Medical College. During medical school, he was awarded an NCI preceptorship allowing him to train under Steven Rosenberg, a world-renowned surgeon and tumor immunologist. This experience kindled Dr. Jablons lifelong interest in translational and precision medicine. Dr. Jablons then completed his general surgery residency at Tufts-New England Medical Center and his thoracic surgery residency at what is now New York Presbyterian-Weill Cornell Medical Center. His mentors included Robert Ginsburg at Memorial Sloan-Kettering and David Sugarbaker at Brigham & Women's Hospital, both world-renown thoracic surgical oncologists. Dr. Jablons also served as a Navy commander while Chief of Thoracic Surgery at the Oakland Naval Hospital. In 1997, he was named Chief of General Thoracic Surgery at UCSF.

    Dr. Jablons is a highly accomplished thoracic surgeon, widely sought out by patients in the Bay Area and world-wide. One patient, Bonnie J. Addario, after recovering from an arduous lung cancer surgery, started a foundation bearing her name she co-founded with Dr. Jablons. Today, the Addario Foundation is one of the leading underwriters of lung cancer research. Dr. Jablons has also been a dedicated teacher and outstanding mentor for both for clinical fellows and surgical residents, the latter including Dan Raz and Johannes Kratz, protégés with an enviable and prolific record of publications who helped spearhead development of predictive and prognostic tools for lung cancer treatment in the lab.

    Dr. Jablons has been a trailblazer in educational outreach, co-founding the UCSF Thoracic Oncology Conference, an annual symposium that provided expert training for thousands of community surgeons for over a decade. He also was instrumental in establishing the China Clinical Trials Consortium to find more effective treatments for lung cancer, and to ameliorate the epidemic of lung cancer in China. In 2009, he led the effort to bring World Conference on Lung Cancer to San Francisco, the preeminent event in the field, in which he served as co-Chair.

    He is a member of numerous professional organizations including the Society of Thoracic Surgeons, the American College of Chest Physicians, the American Association for Cancer Research and the International Association for the Study of Lung Cancer (IASLC). Highly respected by his peers, Dr. Jablons was named to the list of U.S. News "America's Top Doctors," a distinction reserved for the top 1% of physicians in the nation for a given specialty. Dr. Jablons was recently inducted into the American Surgical Society, the nation's most prestigious.


    Collapse Research 
    Collapse Research Activities and Funding
    Inflammation and Lung Carcinogenesis
    NIH/NCI R01CA132566May 1, 2008 - Mar 31, 2014
    Role: Principal Investigator
    The Wnt Pathway in Malignant Mesothelioma
    NIH/NCI R01CA093708Mar 1, 2005 - Feb 28, 2010
    Role: Principal Investigator

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    Collapse In The News
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Hsu PC, Miao J, Huang Z, Yang YL, Xu Z, You J, Dai Y, Yeh CC, Chan G, Liu S, Urisman A, Yang CT, Jablons D, You L. Inhibition of yes-associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model. J Cell Mol Med. 2018 Mar 24. PMID: 29575527.
      View in: PubMed
    2. Hsu PC, Miao J, Wang YC, Zhang WQ, Yang YL, Wang CW, Yang CT, Huang Z, You J, Xu Z, Jablons D, You L. Inhibition of yes-associated protein down-regulates PD-L1 (CD274) expression in human malignant pleural mesothelioma. J Cell Mol Med. 2018 Mar 24. PMID: 29575535.
      View in: PubMed
    3. Tolani B, Hoang NT, Acevedo LA, Leprieur EG, Li H, He B, Jablons D. Preclinical characterization of therapeutic antibodies targeted at the carboxy-terminus of Sonic hedgehog. Oncotarget. 2018 Mar 06; 9(18):14311-14323. PMID: 29581846.
      View in: PubMed
    4. Leprieur EG, Jablons D, He B. Old Sonic Hedgehog, new tricks: a new paradigm in thoracic malignancies. Oncotarget. 2018 Mar 06; 9(18):14680-14691. PMID: 29581874.
      View in: PubMed
    5. Miao J, Hsu PC, Yang YL, Xu Z, Dai Y, Wang Y, Chan G, Huang Z, Hu B, Li H, Jablons D, You L. YAP regulates PD-L1 expression in human NSCLC cells. Oncotarget. 2017 Dec 29; 8(70):114576-114587. PMID: 29383103.
      View in: PubMed
    6. Wang L, Jin JQ, Zhou Y, Tian Z, Jablons D, He B. Gli is activated and promotes epithelial-mesenchymal transition in human esophageal adenocarcinoma. Oncotarget. 2018 Jan 02; 9(1):853-865. PMID: 29416661.
      View in: PubMed
    7. Leprieur EG, Tolani B, Li H, Leguay F, Hoang NT, Acevedo LA, Jin JQ, Tseng HH, Yue D, Kim IJ, Wislez M, Wang C, Jablons D, He B. Membrane-bound full-length Sonic Hedgehog identifies cancer stem cells in human non-small cell lung cancer. Oncotarget. 2017 Nov 28; 8(61):103744-103757. PMID: 29262597.
      View in: PubMed
    8. Wang VE, Urisman A, Albacker L, Ali S, Miller V, Aggarwal R, Jablons D. Checkpoint inhibitor is active against large cell neuroendocrine carcinoma with high tumor mutation burden. J Immunother Cancer. 2017 Sep 19; 5(1):75. PMID: 28923100.
      View in: PubMed
    9. Dai Y, Jablons D, You L. Hippo pathway in lung development. J Thorac Dis. 2017 Aug; 9(8):2246-2250. PMID: 28932516.
      View in: PubMed
    10. Mendez P, Fang LT, Jablons D, Kim IJ. Systematic comparison of two whole-genome amplification methods for targeted next-generation sequencing using frozen and FFPE normal and cancer tissues. Sci Rep. 2017 Jun 22; 7(1):4055. PMID: 28642587.
      View in: PubMed
    11. Woodard GA, Yang YL, You L, Jablons D. Drug development against the hippo pathway in mesothelioma. Transl Lung Cancer Res. 2017 Jun; 6(3):335-342. PMID: 28713678.
      View in: PubMed
    12. Woodard GA, Wang SX, Kratz JR, Zoon-Besselink CT, Chiang CY, Gubens MA, Jahan TM, Blakely CM, Jones KD, Mann MJ, Jablons D. Adjuvant Chemotherapy Guided by Molecular Profiling and Improved Outcomes in Early Stage, Non-Small-Cell Lung Cancer. Clin Lung Cancer. 2018 Jan; 19(1):58-64. PMID: 28645632.
      View in: PubMed
    13. Wang H, Dai YY, Zhang WQ, Hsu PC, Yang YL, Wang YC, Chan G, Au A, Xu ZD, Jiang SJ, Wang W, Jablons D, You L. DCLK1 is correlated with MET and ERK5 expression, and associated with prognosis in malignant pleural mesothelioma. Int J Oncol. 2017 Jul; 51(1):91-103. PMID: 28560410.
      View in: PubMed
    14. Kratz JR, Woodard G, Jablons D. Management of Lung Cancer Invading the Superior Sulcus. Thorac Surg Clin. 2017 May; 27(2):149-157. PMID: 28363369.
      View in: PubMed
    15. Yoon JH, Kim TW, Mendez P, Jablons D, Kim IJ. Mobile Genome Express (MGE): A comprehensive automatic genetic analyses pipeline with a mobile device. PLoS One. 2017; 12(4):e0174696. PMID: 28403238.
      View in: PubMed
    16. Dai Y, Liu S, Zhang WQ, Yang YL, Hang P, Wang H, Cheng L, Hsu PC, Wang YC, Xu Z, Jablons D, You L. YAP1 regulates ABCG2 and cancer cell side population in human lung cancer cells. Oncotarget. 2017 Jan 17; 8(3):4096-4109. PMID: 27911857.
      View in: PubMed
    17. Li H, Yue D, Jin JQ, Woodard GA, Tolani B, Luh TM, Giroux-Leprieur E, Mo M, Chen Z, Che J, Zhang Z, Zhou Y, Wang L, Hao X, Jablons D, Wang C, He B. Gli promotes epithelial-mesenchymal transition in human lung adenocarcinomas. Oncotarget. 2016 Dec 06; 7(49):80415-80425. PMID: 27533453.
      View in: PubMed
    18. Kang HC, Kim JI, Chang HK, Woodard G, Choi YS, Ku JL, Jablons D, Kim IJ. FAIM2, as a novel diagnostic maker and a potential therapeutic target for small-cell lung cancer and atypical carcinoid. Sci Rep. 2016 Sep 28; 6:34022. PMID: 27677402.
      View in: PubMed
    19. Woodard GA, Crockard JC, Clary-Macy C, Zoon-Besselink CT, Jones K, Korn WM, Ko AH, Gottschalk AR, Rogers SJ, Jablons D. Hybrid minimally invasive Ivor Lewis esophagectomy after neoadjuvant chemoradiation yields excellent long-term survival outcomes with minimal morbidity. J Surg Oncol. 2016 Dec; 114(7):838-847. PMID: 27569043.
      View in: PubMed
    20. Dang J, Mendez P, Lee S, Kim JW, Yoon JH, Kim TW, Sailey CJ, Jablons D, Kim IJ. Development of a robust DNA quality and quantity assessment qPCR assay for targeted next-generation sequencing library preparation. Int J Oncol. 2016 Oct; 49(4):1755-65. PMID: 27511764; PMCID: PMC5021246.
    21. Hsu PC, You B, Yang YL, Zhang WQ, Wang YC, Xu Z, Dai Y, Liu S, Yang CT, Li H, Hu B, Jablons D, You L. YAP promotes erlotinib resistance in human non-small cell lung cancer cells. Oncotarget. 2016 Aug 09; 7(32):51922-51933. PMID: 27409162.
      View in: PubMed
    22. Xu Y, Ding VW, Zhang H, Zhang X, Jablons D, He B. Spotlight on afatinib and its potential in the treatment of squamous cell lung cancer: the evidence so far. Ther Clin Risk Manag. 2016; 12:807-16. PMID: 27307741; PMCID: PMC4888861.
    23. Mendez P, Dang J, Kim JW, Lee S, Yoon JH, Kim T, Sailey CJ, Jablons D, Kim IJ. Comprehensive evaluation and validation of targeted next-generation sequencing performance in two clinical laboratories. Int J Oncol. 2016 Jul; 49(1):235-42. PMID: 27121194.
      View in: PubMed
    24. Hung MS, Chen IC, You L, Jablons D, Li YC, Mao JH, Xu Z, Lung JH, Yang CT, Liu ST. Knockdown of cullin 4A inhibits growth and increases chemosensitivity in lung cancer cells. J Cell Mol Med. 2016 07; 20(7):1295-306. PMID: 26969027; PMCID: PMC4929302.
    25. Kang HC, Kim HK, Lee S, Mendez P, Kim JW, Woodard G, Yoon JH, Jen KY, Fang LT, Jones K, Jablons D, Kim IJ. Whole exome and targeted deep sequencing identify genome-wide allelic loss and frequent SETDB1 mutations in malignant pleural mesotheliomas. Oncotarget. 2016 Feb 16; 7(7):8321-31. PMID: 26824986; PMCID: PMC4884995.
    26. Lui NS, Yang YW, van Zante A, Buchanan P, Jablons D, Lemjabbar-Alaoui H. SULF2 Expression Is a Potential Diagnostic and Prognostic Marker in Lung Cancer. PLoS One. 2016; 11(2):e0148911. PMID: 26882224; PMCID: PMC4755530.
    27. Woodard GA, Jones KD, Jablons D. Lung Cancer Staging and Prognosis. Cancer Treat Res. 2016; 170:47-75. PMID: 27535389.
      View in: PubMed
    28. Hung MS, Chen IC, You L, Jablons D, Li YC, Mao JH, Xu Z, Hsieh MJ, Lin YC, Yang CT, Liu ST, Tsai YH. Knockdown of Cul4A increases chemosensitivity to gemcitabine through upregulation of TGFBI in lung cancer cells. Oncol Rep. 2015 Dec; 34(6):3187-95. PMID: 26503734.
      View in: PubMed
    29. Yang YL, Ni J, Hsu PC, Mao JH, Hsieh D, Xu A, Chan G, Au A, Xu Z, Jablons D, You L. Cul4A overexpression associated with Gli1 expression in malignant pleural mesothelioma. J Cell Mol Med. 2015 Oct; 19(10):2385-96. PMID: 26218750; PMCID: PMC4594680.
    30. Yue D, Li H, Che J, Zhang Y, Tolani B, Mo M, Zhang H, Zheng Q, Yang Y, Cheng R, Jin JQ, Luh TW, Yang C, Tseng HH, Giroux-Leprieur E, Woodard GA, Hao X, Wang C, Jablons D, He B. EMX2 Is a Predictive Marker for Adjuvant Chemotherapy in Lung Squamous Cell Carcinomas. PLoS One. 2015; 10(7):e0132134. PMID: 26132438; PMCID: PMC4488446.
    31. Cox JC, Jablons D. Operative and Perioperative Pulmonary Emboli. Thorac Surg Clin. 2015 Aug; 25(3):289-99. PMID: 26210925.
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    32. Wang Y, Xu Z, Mao JH, Hung MS, Hsieh D, Au A, Jablons D, You L. Analysis of lung tumor initiation and progression in transgenic mice for Cre-inducible overexpression of Cul4A gene. Thorac Cancer. 2015 Jul; 6(4):480-7. PMID: 26273405; PMCID: PMC4511328.
    33. Wang Y, Xu Z, Mao JH, Hsieh D, Au A, Jablons D, Li H, You L. PR-Set7 is Degraded in a Conditional Cul4A Transgenic Mouse Model of Lung Cancer. Zhongguo Fei Ai Za Zhi. 2015 Jun; 18(6):345-50. PMID: 26104890.
      View in: PubMed
    34. Brand OJ, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Baron JL, Nishimura SL. Transforming Growth Factor-ß and Interleukin-1ß Signaling Pathways Converge on the Chemokine CCL20 Promoter. J Biol Chem. 2015 Jun 05; 290(23):14717-28. PMID: 25918170; PMCID: PMC4505537.
    35. Blakely CM, Pazarentzos E, Olivas V, Asthana S, Yan JJ, Tan I, Hrustanovic G, Chan E, Lin L, Neel DS, Newton W, Bobb KL, Fouts TR, Meshulam J, Gubens MA, Jablons D, Johnson JR, Bandyopadhyay S, Krogan NJ, Bivona TG. NF-?B-activating complex engaged in response to EGFR oncogene inhibition drives tumor cell survival and residual disease in lung cancer. Cell Rep. 2015 Apr 07; 11(1):98-110. PMID: 25843712; PMCID: PMC4394036.
    36. Letteboer TG, Benzinou M, Merrick CB, Quigley DA, Zhau K, Kim IJ, To MD, Jablons D, van Amstel JK, Westermann CJ, Giraud S, Dupuis-Girod S, Lesca G, Berg JH, Balmain A, Akhurst RJ. Genetic variation in the functional ENG allele inherited from the non-affected parent associates with presence of pulmonary arteriovenous malformation in hereditary hemorrhagic telangiectasia 1 (HHT1) and may influence expression of PTPN14. Front Genet. 2015; 6:67. PMID: 25815003; PMCID: PMC4357294.
    37. You B, Yang YL, Xu Z, Dai Y, Liu S, Mao JH, Tetsu O, Li H, Jablons D, You L. Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells. Oncotarget. 2015 Feb 28; 6(6):4357-68. PMID: 25738359; PMCID: PMC4414195.
    38. Hirata T, Zheng Q, Chen Z, Kinoshita H, Okamoto J, Kratz J, Li H, Lui N, Do H, Cheng T, Tseng HH, Koizumi K, Shimizu K, Zhou HM, Jablons D, He B. Wnt7A is a putative prognostic and chemosensitivity marker in human malignant pleural mesothelioma. Oncol Rep. 2015 Apr; 33(4):2052-60. PMID: 25632963; PMCID: PMC4358089.
    39. Woodard GA, Jablons D. The Latest in Surgical Management of Stage IIIA Non-Small Cell Lung Cancer: Video-Assisted Thoracic Surgery and Tumor Molecular Profiling. Am Soc Clin Oncol Educ Book. 2015; e435-41. PMID: 25993207.
      View in: PubMed
    40. Zhang S, Yang YL, Wang Y, You B, Dai Y, Chan G, Hsieh D, Kim IJ, Fang LT, Au A, Stoppler HJ, Xu Z, Jablons D, You L. CK2a, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells. J Exp Clin Cancer Res. 2014 Nov 25; 33:93. PMID: 25422081; PMCID: PMC4254219.
    41. Mo ML, Ma J, Chen Z, Wei B, Li H, Zhou Y, Shi H, Tolani B, Jin JQ, Tseng HH, Shen D, Zhan Y, Li J, Jablons D, Zhang RQ, Guo Y, He B, Zhou HM. Measurement of genome-wide DNA methylation predicts survival benefits from chemotherapy in non-small cell lung cancer. J Cancer Res Clin Oncol. 2015 May; 141(5):901-8. PMID: 25367137.
      View in: PubMed
    42. Capelletti M, Dodge ME, Ercan D, Hammerman PS, Park SI, Kim J, Sasaki H, Jablons D, Lipson D, Young L, Stephens PJ, Miller VA, Lindeman NI, Munir KJ, Richards WG, Jänne PA. Identification of recurrent FGFR3-TACC3 fusion oncogenes from lung adenocarcinoma. Clin Cancer Res. 2014 Dec 15; 20(24):6551-8. PMID: 25294908.
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    43. Woodard GA, Gubens MA, Jahan TM, Jones KD, Kukreja J, Theodore PR, Cardozo S, Jew G, Clary-Macy C, Jablons D, Mann MJ. Prognostic molecular assay might improve identification of patients at risk for recurrence in early-stage non-small-cell lung cancer. Clin Lung Cancer. 2014 Nov; 15(6):426-32. PMID: 25258195.
      View in: PubMed
    44. Yang YL, Jablons D, You L. An alternative way to initiate Notch1 signaling in non-small cell lung cancer. Transl Lung Cancer Res. 2014 Aug; 3(4):238-41. PMID: 25806306; PMCID: PMC4367706.
    45. Okoye CC, Jablons D, Jahan TM, Kukreja J, Cardozo S, Yom SS. Divergent management strategies for typical versus atypical carcinoid tumors of the thoracic cavity. Am J Clin Oncol. 2014 Aug; 37(4):350-5. PMID: 23357970.
      View in: PubMed
    46. Giroux Leprieur E, Hirata T, Mo M, Chen Z, Okamoto J, Clement G, Li H, Wislez M, Jablons D, He B. The homeobox gene EMX2 is a prognostic and predictive marker in malignant pleural mesothelioma. Lung Cancer. 2014 Sep; 85(3):465-71. PMID: 25023662.
      View in: PubMed
    47. Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL. Selective targeting of TGF-ß activation to treat fibroinflammatory airway disease. Sci Transl Med. 2014 Jun 18; 6(241):241ra79. PMID: 24944194; PMCID: PMC4341974.
    48. Yang YL, Hung MS, Wang Y, Ni J, Mao JH, Hsieh D, Au A, Kumar A, Quigley D, Fang LT, Yeh CC, Xu Z, Jablons D, You L. Lung tumourigenesis in a conditional Cul4A transgenic mouse model. J Pathol. 2014 Jun; 233(2):113-23. PMID: 24648314; PMCID: PMC4084828.
    49. Yue D, Li H, Che J, Zhang Y, Tseng HH, Jin JQ, Luh TM, Giroux-Leprieur E, Mo M, Zheng Q, Shi H, Zhang H, Hao X, Wang C, Jablons D, He B. Hedgehog/Gli promotes epithelial-mesenchymal transition in lung squamous cell carcinomas. J Exp Clin Cancer Res. 2014 Apr 24; 33:34. PMID: 24758269; PMCID: PMC4029998.
    50. Okada N, Lin CP, Ribeiro MC, Biton A, Lai G, He X, Bu P, Vogel H, Jablons D, Keller AC, Wilkinson JE, He B, Speed TP, He L. A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression. Genes Dev. 2014 Mar 01; 28(5):438-50. PMID: 24532687; PMCID: PMC3950342.
    51. Reza J, Sammann A, Jin C, Horvai A, Hudnall M, Jablons D, Jahan T, Kornak J, Mann MJ. Aggressive and minimally invasive surgery for pulmonary metastasis of sarcoma. J Thorac Cardiovasc Surg. 2014 Apr; 147(4):1193-200; discussion 1200-1. PMID: 24507991.
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    52. Fang LT, Lee S, Choi H, Kim HK, Jew G, Kang HC, Chen L, Jablons D, Kim IJ. Comprehensive genomic analyses of a metastatic colon cancer to the lung by whole exome sequencing and gene expression analysis. Int J Oncol. 2014 Jan; 44(1):211-21. PMID: 24172857.
      View in: PubMed
    53. Zhi X, Gao W, Han B, Yang Y, Li H, Liu D, Wang C, Min G, Long H, Rigas JR, Carey M, Jahan T, Sammann A, Reza J, Wang D, Mann MJ, Jablons D, He J. VATS lobectomy facilitates the delivery of adjuvant docetaxel-carboplatin chemotherapy in patients with non-small cell lung cancer. J Thorac Dis. 2013 Oct; 5(5):578-84. PMID: 24255769; PMCID: PMC3815738.
    54. Hung MS, Xu Z, Chen Y, Smith E, Mao JH, Hsieh D, Lin YC, Yang CT, Jablons D, You L. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model. Int J Oncol. 2013 Nov; 43(5):1517-22. PMID: 24008396; PMCID: PMC3823374.
    55. Lau D, Yarlagadda J, Jahan T, Jablons D, Chou D. Desmoplastic fibroma of the spine causing severe mediastinal compression and brachial plexus encasement: report of 2 cases. J Neurosurg Spine. 2013 Oct; 19(4):515-20. PMID: 23952324.
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    56. Mo ML, Okamoto J, Chen Z, Hirata T, Mikami I, Bosco-Clément G, Li H, Zhou HM, Jablons D, He B. Down-regulation of SIX3 is associated with clinical outcome in lung adenocarcinoma. PLoS One. 2013; 8(8):e71816. PMID: 23977152; PMCID: PMC3745425.
    57. Ganesan AP, Johansson M, Ruffell B, Yagui-Beltrán A, Beltran A, Lau J, Jablons D, Coussens LM. Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma. J Immunol. 2013 Aug 15; 191(4):2009-17. PMID: 23851682; PMCID: PMC3774528.
    58. Liu S, Hsieh D, Yang YL, Xu Z, Peto C, Jablons D, You L. Coumestrol from the national cancer Institute's natural product library is a novel inhibitor of protein kinase CK2. BMC Pharmacol Toxicol. 2013 Jul 11; 14:36. PMID: 23845105; PMCID: PMC3726451.
    59. Bravo DT, Yang YL, Kuchenbecker K, Hung MS, Xu Z, Jablons D, You L. Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer. BMC Cancer. 2013 Jul 01; 13:316. PMID: 23815780; PMCID: PMC3707790.
    60. Kratz JR, Tham PT, Mulvihill MS, Ziaei F, Ray MR, Hurst JW, Segal MR, Berryman DM, Chu W, He B, Jablons D, Mann MJ. Analytical validation of a practical molecular assay prognostic of survival in nonsquamous non-small cell lung cancer. Diagn Mol Pathol. 2013 Jun; 22(2):65-9. PMID: 23628816.
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    61. Kratz JR, Mann MJ, Jablons D. International trial of adjuvant therapy in high risk stage I non-squamous cell carcinoma identified by a 14-gene prognostic signature. Transl Lung Cancer Res. 2013 Jun; 2(3):222-5. PMID: 25806235; PMCID: PMC4367604.
    62. Mo ML, Chen Z, Zhou HM, Li H, Hirata T, Jablons D, He B. Detection of E2A-PBX1 fusion transcripts in human non-small-cell lung cancer. J Exp Clin Cancer Res. 2013 May 20; 32:29. PMID: 23688269; PMCID: PMC3661382.
    63. Zhang S, Long H, Yang YL, Wang Y, Hsieh D, Li W, Au A, Stoppler HJ, Xu Z, Jablons D, You L. Inhibition of CK2a down-regulates Notch1 signalling in lung cancer cells. J Cell Mol Med. 2013 Jul; 17(7):854-62. PMID: 23651443; PMCID: PMC3729857.
    64. Li H, Lui N, Cheng T, Tseng HH, Yue D, Giroux-Leprieur E, Do HT, Sheng Q, Jin JQ, Luh TW, Jablons D, He B. Gli as a novel therapeutic target in malignant pleural mesothelioma. PLoS One. 2013; 8(3):e57346. PMID: 23483902; PMCID: PMC3590216.
    65. Mann MJ, Jablons D, Kratz JR. Prognostic assay in small, node-negative non-small cell lung cancer--reply. JAMA. 2013 Feb 27; 309(8):769-70. PMID: 23443437.
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    66. Zhang Y, He J, Zhang F, Li H, Yue D, Wang C, Jablons D, He B, Lui N. SMO expression level correlates with overall survival in patients with malignant pleural mesothelioma. J Exp Clin Cancer Res. 2013 Feb 05; 32:7. PMID: 23379358; PMCID: PMC3622612.
    67. Kim IJ, Quigley D, To MD, Pham P, Lin K, Jo B, Jen KY, Raz D, Kim J, Mao JH, Jablons D, Balmain A. Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas. Nat Commun. 2013; 4:1701. PMID: 23591868; PMCID: PMC4450149.
    68. Tsao MS, Jablons D. Molecular prognostication of non-small cell lung cancer. Semin Thorac Cardiovasc Surg. 2013; 25(1):4-7. PMID: 23800523.
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    69. Lui NS, van Zante A, Rosen SD, Jablons D, Lemjabbar-Alaoui H. SULF2 expression by immunohistochemistry and overall survival in oesophageal cancer: a cohort study. BMJ Open. 2012; 2(6). PMID: 23180455; PMCID: PMC3532995.
    70. Mulvihill MS, Kratz JR, Pham P, Jablons D, He B. The role of stem cells in airway repair: implications for the origins of lung cancer. Chin J Cancer. 2013 Feb; 32(2):71-4. PMID: 23114089; PMCID: PMC3845611.
    71. Kratz JR, Van den Eeden SK, He J, Jablons D, Mann MJ. A prognostic assay to identify patients at high risk of mortality despite small, node-negative lung tumors. JAMA. 2012 Oct 24; 308(16):1629-31. PMID: 23093159.
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    72. Mulvihill MS, Kwon YW, Lee S, Fang LT, Choi H, Ray R, Kang HC, Mao JH, Jablons D, Kim IJ. Gremlin is overexpressed in lung adenocarcinoma and increases cell growth and proliferation in normal lung cells. PLoS One. 2012; 7(8):e42264. PMID: 22870311; PMCID: PMC3411619.
    73. Kim JW, Lee S, Lui N, Choi H, Mulvihill M, Fang LT, Kang HC, Kwon YW, Jablons D, Kim IJ. A somatic TSHR mutation in a patient with lung adenocarcinoma with bronchioloalveolar carcinoma, coronary artery disease and severe chronic obstructive pulmonary disease. Oncol Rep. 2012 Oct; 28(4):1225-30. PMID: 22842620.
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    74. Zhang S, Wang Y, Mao JH, Hsieh D, Kim IJ, Hu LM, Xu Z, Long H, Jablons D, You L. Inhibition of CK2a down-regulates Hedgehog/Gli signaling leading to a reduction of a stem-like side population in human lung cancer cells. PLoS One. 2012; 7(6):e38996. PMID: 22768056; PMCID: PMC3387212.
    75. Li T, Hou SC, Mao JH, Wang YC, Lu XD, Tan JL, You B, Liu YP, Ni J, Au A, Jablons D, Xu Z, You L. The expression of Dishevelled-3 and glutamine metabolism in malignant pleural mesothelioma. J Clin Pathol. 2012 Sep; 65(9):855-8. PMID: 22569537; PMCID: PMC3422606.
    76. Yom SS, Chen CP, Jahan TM, Jablons D. One size does not fit all lung cancer patients. J Thorac Oncol. 2012 May; 7(5):945. PMID: 22722802.
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    77. Choi H, Kratz J, Pham P, Lee S, Ray R, Kwon YW, Mao JH, Kang HC, Jablons D, Kim IJ. Development of a rapid and practical mutation screening assay for human lung adenocarcinoma. Int J Oncol. 2012 Jun; 40(6):1900-6. PMID: 22407457.
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    78. Kratz JR, He J, Van Den Eeden SK, Zhu ZH, Gao W, Pham PT, Mulvihill MS, Ziaei F, Zhang H, Su B, Zhi X, Quesenberry CP, Habel LA, Deng Q, Wang Z, Zhou J, Li H, Huang MC, Yeh CC, Segal MR, Ray MR, Jones KD, Raz DJ, Xu Z, Jahan TM, Berryman D, He B, Mann MJ, Jablons D. A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies. Lancet. 2012 Mar 03; 379(9818):823-32. PMID: 22285053; PMCID: PMC3294002.
    79. Chen CP, Weinberg VK, Jahan TM, Jablons D, Yom SS. Implications of delayed initiation of radiotherapy: accelerated repopulation after induction chemotherapy for stage III non-small cell lung cancer. J Thorac Oncol. 2011 Nov; 6(11):1857-64. PMID: 21964528.
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    80. Markovics JA, Araya J, Cambier S, Somanath S, Gline S, Jablons D, Hill A, Wolters PJ, Nishimura SL. Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture. J Biol Chem. 2011 Oct 21; 286(42):36864-74. PMID: 21878622; PMCID: PMC3196125.
    81. Schmid S, Bieber M, Zhang F, Zhang M, He B, Jablons D, Teng NN. Wnt and hedgehog gene pathway expression in serous ovarian cancer. Int J Gynecol Cancer. 2011 Aug; 21(6):975-80. PMID: 21666490; PMCID: PMC3285558.
    82. Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL. Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin avß8-mediated activation of TGF-ß. J Clin Invest. 2011 Jul; 121(7):2863-75. PMID: 21646718; PMCID: PMC3223836.
    83. Okamoto J, Kratz JR, Hirata T, Mikami I, Raz D, Segal M, Chen Z, Zhou HM, Pham P, Li H, Yagui-Beltran A, Beltran A, Ray MR, Koizumi K, Shimizu K, Jablons D, He B. Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma patients. Clin Lung Cancer. 2011 Jul; 12(4):237-44. PMID: 21726823; PMCID: PMC3285542.
    84. Li T, Hung MS, Wang Y, Mao JH, Tan JL, Jahan K, Roos H, Xu Z, Jablons D, You L. Transgenic mice for cre-inducible overexpression of the Cul4A gene. Genesis. 2011 Mar; 49(3):134-41. PMID: 21381181; PMCID: PMC3285554.
    85. Hung MS, Mao JH, Xu Z, Yang CT, Yu JS, Harvard C, Lin YC, Bravo DT, Jablons D, You L. Cul4A is an oncogene in malignant pleural mesothelioma. J Cell Mol Med. 2011 Feb; 15(2):350-8. PMID: 19929949; PMCID: PMC3355981.
    86. Li T, Li H, Wang Y, Harvard C, Tan JL, Au A, Xu Z, Jablons D, You L. The expression of CXCR4, CXCL12 and CXCR7 in malignant pleural mesothelioma. J Pathol. 2011 Mar; 223(4):519-30. PMID: 21294125; PMCID: PMC3085597.
    87. Mikami I, Zhang F, Hirata T, Okamoto J, Koizumi K, Shimizu K, Jablons D, He B. Inhibition of activated phosphatidylinositol 3-kinase/AKT pathway in malignant pleural mesothelioma leads to G1 cell cycle arrest. Oncol Rep. 2010 Dec; 24(6):1677-81. PMID: 21042767.
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    88. Lin YC, Lin CK, Tsai YH, Weng HH, Li YC, You L, Chen JK, Jablons D, Yang CT. Adenovirus-mediated SOCS3 gene transfer inhibits the growth and enhances the radiosensitivity of human non-small cell lung cancer cells. Oncol Rep. 2010 Dec; 24(6):1605-12. PMID: 21042758.
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    89. Ray MR, Jablons D, He B. Lung cancer therapeutics that target signaling pathways: an update. Expert Rev Respir Med. 2010 Oct; 4(5):631-45. PMID: 20923341; PMCID: PMC3031455.
    90. Hung MS, Lin YC, Mao JH, Kim IJ, Xu Z, Yang CT, Jablons D, You L. Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer. PLoS One. 2010 Jul 02; 5(7):e11418. PMID: 20625391; PMCID: PMC2896393.
    91. Markovics JA, Araya J, Cambier S, Jablons D, Hill A, Wolters PJ, Nishimura SL. Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway. J Biol Chem. 2010 Aug 06; 285(32):24695-706. PMID: 20519498; PMCID: PMC2915706.
    92. Kratz JR, Yagui-Beltrán A, Jablons D. Cancer stem cells in lung tumorigenesis. Ann Thorac Surg. 2010 Jun; 89(6):S2090-5. PMID: 20493987; PMCID: PMC3053146.
    93. Wang YC, Iezza G, Zuraek MB, Jablons D, Theodore PR, Bergsland EK, Donner DB, Warren RS, Nakakura EK. Lack of NKX2.2 expression in bronchopulmonary typical carcinoid tumors: implications for patients with neuroendocrine tumor metastases and unknown primary site. J Surg Res. 2010 Sep; 163(1):47-51. PMID: 20599218.
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    94. More SS, Li S, Yee SW, Chen L, Xu Z, Jablons D, Giacomini KM. Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue. Mol Cancer Ther. 2010 Apr; 9(4):1058-69. PMID: 20371711; PMCID: PMC3258025.
    95. Campos GM, Jablons D, Brown LM, Ramirez RM, Rabl C, Theodore P. A safe and reproducible anastomotic technique for minimally invasive Ivor Lewis oesophagectomy: the circular-stapled anastomosis with the trans-oral anvil. Eur J Cardiothorac Surg. 2010 Jun; 37(6):1421-6. PMID: 20153660; PMCID: PMC2878854.
    96. Gao Z, Xu Z, Hung MS, Lin YC, Wang T, Gong M, Zhi X, Jablons D, You L. Procaine and procainamide inhibit the Wnt canonical pathway by promoter demethylation of WIF-1 in lung cancer cells. Oncol Rep. 2009 Dec; 22(6):1479-84. PMID: 19885602.
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    97. Yagui-Beltrán A, Jablons D. A translational approach to lung cancer research: From EGFRs to Wnt and cancer stem cells. Ann Thorac Cardiovasc Surg. 2009 Aug; 15(4):213-20. PMID: 19763051; PMCID: PMC3066262.
    98. Hung MS, Xu Z, Lin YC, Mao JH, Yang CT, Chang PJ, Jablons D, You L. Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library. BMC Cancer. 2009 May 06; 9:135. PMID: 19419583; PMCID: PMC2696466.
    99. Kratz JR, Jablons D. Genomic prognostic models in early-stage lung cancer. Clin Lung Cancer. 2009 May; 10(3):151-7. PMID: 19443334.
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    100. Kashani-Sabet M, Rangel J, Torabian S, Nosrati M, Simko J, Jablons D, Moore DH, Haqq C, Miller JR, Sagebiel RW. A multi-marker assay to distinguish malignant melanomas from benign nevi. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6268-72. PMID: 19332774; PMCID: PMC2662963.
    101. Yagui-Beltrán A, Coussens LM, Jablons D. Respiratory Homeostasis and Exploitation of the Immune System for Lung Cancer Vaccines. US Oncol. 2009; 58(1):40-48. PMID: 22368692.
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    102. Raz DJ, Gomez SL, Chang ET, Kim JY, Keegan TH, Pham J, Kukreja J, Hiatt RA, Jablons D. Epidemiology of non-small cell lung cancer in Asian Americans: incidence patterns among six subgroups by nativity. J Thorac Oncol. 2008 Dec; 3(12):1391-7. PMID: 19057262.
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    103. Yagui-Beltrán A, He B, Jablons D. The role of cancer stem cells in neoplasia of the lung: past, present and future. Clin Transl Oncol. 2008 Nov; 10(11):719-25. PMID: 19015068.
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    104. Okamoto J, Mikami I, Tominaga Y, Kuchenbecker KM, Lin YC, Bravo DT, Clement G, Yagui-Beltran A, Ray MR, Koizumi K, He B, Jablons D. Inhibition of Hsp90 leads to cell cycle arrest and apoptosis in human malignant pleural mesothelioma. J Thorac Oncol. 2008 Oct; 3(10):1089-95. PMID: 18827603; PMCID: PMC2656438.
    105. Raz DJ, Ray MR, Kim JY, He B, Taron M, Skrzypski M, Segal M, Gandara DR, Rosell R, Jablons D. A multigene assay is prognostic of survival in patients with early-stage lung adenocarcinoma. Clin Cancer Res. 2008 Sep 01; 14(17):5565-70. PMID: 18765549.
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    106. Skrzypski M, Jassem E, Taron M, Sanchez JJ, Mendez P, Rzyman W, Gulida G, Raz D, Jablons D, Provencio M, Massuti B, Chaib I, Perez-Roca L, Jassem J, Rosell R. Three-gene expression signature predicts survival in early-stage squamous cell carcinoma of the lung. Clin Cancer Res. 2008 Aug 01; 14(15):4794-9. PMID: 18676750.
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    107. Chou J, Lin YC, Kim J, You L, Xu Z, He B, Jablons D. Nasopharyngeal carcinoma--review of the molecular mechanisms of tumorigenesis. Head Neck. 2008 Jul; 30(7):946-63. PMID: 18446839; PMCID: PMC3046044.
    108. You L, Xu Z, Punchihewa C, Jablons D, Fujii N. Evaluation of a chemical library of small-molecule Dishevelled antagonists that suppress tumor growth by down-regulating T-cell factor-mediated transcription. Mol Cancer Ther. 2008 Jun; 7(6):1633-8. PMID: 18566234.
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    109. Wilson SM, Barbone D, Yang TM, Jablons D, Bueno R, Sugarbaker DJ, Nishimura SL, Gordon GJ, Broaddus VC. mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids. Am J Respir Cell Mol Biol. 2008 Nov; 39(5):576-83. PMID: 18511708; PMCID: PMC2574528.
    110. Calhoun R, Jablons D, Lau D, Gandara DR. Adjuvant treatment of stage IB NSCLC: the problem of stage subset heterogeneity. Oncology (Williston Park). 2008 Apr 30; 22(5):511-6; discussion 516, 521-3. PMID: 18533401.
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    111. Rosell R, de Las Peñas R, Balaña C, Santarpia M, Salazar F, de Aguirre I, Reguart N, Villa S, Wei J, Ramirez JL, Molina MA, Ramon y Cajal S, Jablons D, Taron M. Translational research in glioblastoma multiforme: molecular criteria for patient selection. Future Oncol. 2008 Apr; 4(2):219-28. PMID: 18407735.
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    112. Kim J, Raz D, Jablons D. Unmet need in lung cancer: can vaccines bridge the gap? Clin Lung Cancer. 2008 Feb; 9 Suppl 1:S6-12. PMID: 18540529.
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    113. Gautschi O, Mack PC, Davies AM, Jablons D, Rosell R, Gandara DR. Pharmacogenomic approaches to individualizing chemotherapy for non-small-cell lung cancer: current status and new directions. Clin Lung Cancer. 2008; 9 Suppl 3:S129-38. PMID: 19419927.
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    114. Yagui-Beltrán A, Jablons D. Optimal surgical management of Stage I non-small-cell lung cancer in an increasingly aging population: challenges and recent progress. Expert Rev Respir Med. 2007 Dec; 1(3):343-53. PMID: 20477174.
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    115. Mazières J, Tovar D, He B, Nieto-Acosta J, Marty-Detraves C, Clanet C, Pradines A, Jablons D, Favre G. Epigenetic regulation of RhoB loss of expression in lung cancer. BMC Cancer. 2007 Nov 30; 7:220. PMID: 18047684; PMCID: PMC2222678.
    116. Clément G, Guilleret I, He B, Yagui-Beltrán A, Lin YC, You L, Xu Z, Shi Y, Okamoto J, Benhattar J, Jablons D. Epigenetic alteration of the Wnt inhibitory factor-1 promoter occurs early in the carcinogenesis of Barrett's esophagus. Cancer Sci. 2008 Jan; 99(1):46-53. PMID: 18005197.
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    117. Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL. Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest. 2007 Nov; 117(11):3551-62. PMID: 17965775; PMCID: PMC2040320.
    118. Uematsu K, Seki N, Seto T, Isoe C, Tsukamoto H, Mikami I, You L, He B, Xu Z, Jablons D, Eguchi K. Targeting the Wnt signaling pathway with dishevelled and cisplatin synergistically suppresses mesothelioma cell growth. Anticancer Res. 2007 Nov-Dec; 27(6B):4239-42. PMID: 18225596.
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    119. Shi Y, He B, Kuchenbecker KM, You L, Xu Z, Mikami I, Yagui-Beltran A, Clement G, Lin YC, Okamoto J, Bravo DT, Jablons D. Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells. Int J Cancer. 2007 Sep 15; 121(6):1175-81. PMID: 17534895.
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    120. Shi Y, He B, You L, Jablons D. Roles of secreted frizzled-related proteins in cancer. Acta Pharmacol Sin. 2007 Sep; 28(9):1499-504. PMID: 17723183.
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    121. Brouchet L, Bauvin E, Marcheix B, Bigay-Game L, Renaud C, Berjaud J, Falcoze PE, Venissac N, Raz D, Jablons D, Mazières J, Dahan M. Impact of induction treatment on postoperative complications in the treatment of non-small cell lung cancer. J Thorac Oncol. 2007 Jul; 2(7):626-31. PMID: 17607118.
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    122. Gandara DR, Wakelee H, Calhoun R, Jablons D. Adjuvant chemotherapy of stage I non-small cell lung cancer in North America. J Thorac Oncol. 2007 Jul; 2(7 Suppl 3):S125-7. PMID: 17603308.
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    123. Raz DJ, Kim JY, Jablons D. Diagnosis and treatment of bronchioloalveolar carcinoma. Curr Opin Pulm Med. 2007 Jul; 13(4):290-6. PMID: 17534175.
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    124. Raz DJ, Jablons D. EGFR expression and mutational analysis as a predictive test. J Clin Oncol. 2007 May 20; 25(15):2144; author reply 2144-5. PMID: 17513827.
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    125. Raz DJ, Zell JA, Ou SH, Gandara DR, Anton-Culver H, Jablons D. Natural history of stage I non-small cell lung cancer: implications for early detection. Chest. 2007 Jul; 132(1):193-9. PMID: 17505036.
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    126. Lee AY, Raz DJ, He B, Jablons D. Update on the molecular biology of malignant mesothelioma. Cancer. 2007 Apr 15; 109(8):1454-61. PMID: 17348013.
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    127. Chen AM, Jahan TM, Jablons D, Garcia J, Larson DA. Risk of cerebral metastases and neurological death after pathological complete response to neoadjuvant therapy for locally advanced nonsmall-cell lung cancer: clinical implications for the subsequent management of the brain. Cancer. 2007 Apr 15; 109(8):1668-75. PMID: 17342770.
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    128. Raz DJ, Jablons D. Five-gene signature in non-small-cell lung cancer. N Engl J Med. 2007 Apr 12; 356(15):1582; author reply 1583. PMID: 17436432.
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    129. Lin YC, You L, Xu Z, He B, Yang CT, Chen JK, Mikami I, Clément G, Shi Y, Kuchenbecker K, Okamoto J, Kashani-Sabet M, Jablons D. Wnt inhibitory factor-1 gene transfer inhibits melanoma cell growth. Hum Gene Ther. 2007 Apr; 18(4):379-86. PMID: 17472570.
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    130. Clément G, Jablons D, Benhattar J. Targeting the Wnt signaling pathway to treat Barrett's esophagus. Expert Opin Ther Targets. 2007 Mar; 11(3):375-89. PMID: 17298295.
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    131. Kim J, You L, Xu Z, Kuchenbecker K, Raz D, He B, Jablons D. Wnt inhibitory factor inhibits lung cancer cell growth. J Thorac Cardiovasc Surg. 2007 Mar; 133(3):733-7. PMID: 17320573.
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    132. Raz DJ, Glidden DV, Odisho AY, Jablons D. Clinical characteristics and survival of patients with surgically resected, incidentally detected lung cancer. J Thorac Oncol. 2007 Feb; 2(2):125-30. PMID: 17410027.
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    133. Fujii N, You L, Xu Z, Uematsu K, Shan J, He B, Mikami I, Edmondson LR, Neale G, Zheng J, Guy RK, Jablons D. An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth. Cancer Res. 2007 Jan 15; 67(2):573-9. PMID: 17234765.
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    134. Kim JY, Harvard C, You L, Xu Z, Kuchenbecker K, Baehner R, Jablons D. Stathmin is overexpressed in malignant mesothelioma. Anticancer Res. 2007 Jan-Feb; 27(1A):39-44. PMID: 17352214.
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    135. Leong SP, Cady B, Jablons D, Garcia-Aguilar J, Reintgen D, Werner JA, Kitagawa Y. Patterns of metastasis in human solid cancers. Cancer Treat Res. 2007; 135:209-21. PMID: 17953419.
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    136. Raz DJ, Odisho AY, Franc BL, Jablons D. Tumor fluoro-2-deoxy-D-glucose avidity on positron emission tomographic scan predicts mortality in patients with early-stage pure and mixed bronchioloalveolar carcinoma. J Thorac Cardiovasc Surg. 2006 Nov; 132(5):1189-95. PMID: 17059942.
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    137. Raz DJ, Zell JA, Karnezis AN, Odisho A, Ignatius Ou SH, Anton-Culver H, Jablons D. Misclassification of bronchioloalveolar carcinoma with cytologic diagnosis of lung cancer. J Thorac Oncol. 2006 Nov; 1(9):943-8. PMID: 17409976.
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    138. Yagui-Beltrán A, He B, Raz D, Kim J, Jablons D. Novel therapies targeting signaling pathways in lung cancer. Thorac Surg Clin. 2006 Nov; 16(4):379-96, vi. PMID: 17240825.
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    139. Zhou BB, Peyton M, He B, Liu C, Girard L, Caudler E, Lo Y, Baribaud F, Mikami I, Reguart N, Yang G, Li Y, Yao W, Vaddi K, Gazdar AF, Friedman SM, Jablons D, Newton RC, Fridman JS, Minna JD, Scherle PA. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell. 2006 Jul; 10(1):39-50. PMID: 16843264; PMCID: PMC4451119.
    140. Raz DJ, He B, Rosell R, Jablons D. Current concepts in bronchioloalveolar carcinoma biology. Clin Cancer Res. 2006 Jun 15; 12(12):3698-704. PMID: 16778095.
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    141. Leong SP, Cady B, Jablons D, Garcia-Aguilar J, Reintgen D, Jakub J, Pendas S, Duhaime L, Cassell R, Gardner M, Giuliano R, Archie V, Calvin D, Mensha L, Shivers S, Cox C, Werner JA, Kitagawa Y, Kitajima M. Clinical patterns of metastasis. Cancer Metastasis Rev. 2006 Jun; 25(2):221-32. PMID: 16770534.
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    142. Raz DJ, Jablons D. Bronchioloalveolar carcinoma is not associated with younger age at diagnosis: an analysis of the SEER database. J Thorac Oncol. 2006 May; 1(4):339-43. PMID: 17409881.
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    143. Raz DJ, He B, Rosell R, Jablons D. Bronchioloalveolar carcinoma: a review. Clin Lung Cancer. 2006 Mar; 7(5):313-22. PMID: 16640802.
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    144. Batra S, Shi Y, Kuchenbecker KM, He B, Reguart N, Mikami I, You L, Xu Z, Lin YC, Clément G, Jablons D. Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma. Biochem Biophys Res Commun. 2006 Apr 21; 342(4):1228-32. PMID: 16516163.
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    145. Rosell R, Cecere F, Cognetti F, Cuello M, Sanchez JM, Taron M, Reguart N, Jablons D. Future directions in the second-line treatment of non-small cell lung cancer. Semin Oncol. 2006 Feb; 33(1 Suppl 1):S45-51. PMID: 16472709.
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    146. Lin YC, You L, Xu Z, He B, Mikami I, Thung E, Chou J, Kuchenbecker K, Kim J, Raz D, Yang CT, Chen JK, Jablons D. Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines. Biochem Biophys Res Commun. 2006 Mar 10; 341(2):635-40. PMID: 16427602.
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    147. You L, Kim J, He B, Xu Z, McCormick F, Jablons D. Wnt-1 signal as a potential cancer therapeutic target. Drug News Perspect. 2006 Jan-Feb; 19(1):27-31. PMID: 16550254.
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    148. Reguart N, He B, Taron M, You L, Jablons D, Rosell R. The role of Wnt signaling in cancer and stem cells. Future Oncol. 2005 Dec; 1(6):787-97. PMID: 16556058.
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    149. Mazieres J, You L, He B, Xu Z, Twogood S, Lee AY, Reguart N, Batra S, Mikami I, Jablons D. Wnt2 as a new therapeutic target in malignant pleural mesothelioma. Int J Cancer. 2005 Nov 01; 117(2):326-32. PMID: 15900580.
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    150. Kim KU, Wilson SM, Abayasiriwardana KS, Collins R, Fjellbirkeland L, Xu Z, Jablons D, Nishimura SL, Broaddus VC. A novel in vitro model of human mesothelioma for studying tumor biology and apoptotic resistance. Am J Respir Cell Mol Biol. 2005 Dec; 33(6):541-8. PMID: 16123394; PMCID: PMC2715331.
    151. Taron M, Ichinose Y, Rosell R, Mok T, Massuti B, Zamora L, Mate JL, Manegold C, Ono M, Queralt C, Jahan T, Sanchez JJ, Sanchez-Ronco M, Hsue V, Jablons D, Sanchez JM, Moran T. Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas. Clin Cancer Res. 2005 Aug 15; 11(16):5878-85. PMID: 16115929.
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    152. Mazieres J, You L, He B, Xu Z, Lee AY, Mikami I, McCormick F, Jablons D. Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis. Oncogene. 2005 Aug 11; 24(34):5396-400. PMID: 16007226.
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    153. He B, Barg RN, You L, Xu Z, Reguart N, Mikami I, Batra S, Rosell R, Jablons D. Wnt signaling in stem cells and non-small-cell lung cancer. Clin Lung Cancer. 2005 Jul; 7(1):54-60. PMID: 16098245.
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    154. Mikami I, You L, He B, Xu Z, Batra S, Lee AY, Mazieres J, Reguart N, Uematsu K, Koizumi K, Jablons D. Efficacy of Wnt-1 monoclonal antibody in sarcoma cells. BMC Cancer. 2005 May 24; 5:53. PMID: 15913453; PMCID: PMC1164405.
    155. Mazieres J, He B, You L, Xu Z, Jablons D. Wnt signaling in lung cancer. Cancer Lett. 2005 May 10; 222(1):1-10. PMID: 15837535.
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    156. He B, Reguart N, You L, Mazieres J, Xu Z, Lee AY, Mikami I, McCormick F, Jablons D. Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations. Oncogene. 2005 Apr 21; 24(18):3054-8. PMID: 15735684.
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    157. Hansen EK, Krieg RM, Azar RJ, Jablons D, Jahan TM, Zaloudek CJ. Unusual thoracic problems in patients with malignancies: case 3. Carcinoid tumor of the thymus. J Clin Oncol. 2005 Apr 20; 23(12):2859-61. PMID: 15838001.
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    158. Dresler CM, Olak J, Herndon JE, Richards WG, Scalzetti E, Fleishman SB, Kernstine KH, Demmy T, Jablons D, Kohman L, Daniel TM, Haasler GB, Sugarbaker DJ. Phase III intergroup study of talc poudrage vs talc slurry sclerosis for malignant pleural effusion. Chest. 2005 Mar; 127(3):909-15. PMID: 15764775; PMCID: PMC4644736.
    159. McCowin MJ, Hall TS, Babcock WD, Solinger LL, Hall KW, Jablons D. Changes in radiographic abnormalities in organ donors: associations with lung transplantation. J Heart Lung Transplant. 2005 Mar; 24(3):323-30. PMID: 15737760.
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    160. He B, Lee AY, Dadfarmay S, You L, Xu Z, Reguart N, Mazieres J, Mikami I, McCormick F, Jablons D. Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells. Cancer Res. 2005 Feb 01; 65(3):743-8. PMID: 15705870.
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    161. Carter YM, Shagrun L, Klein H, Katz J, Jablons D. Salmonella infection in an anterior mediastinal mass. J Thorac Cardiovasc Surg. 2005 Jan; 129(1):228-30. PMID: 15632855.
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    162. Lee AY, He B, You L, Xu Z, Mazieres J, Reguart N, Mikami I, Batra S, Jablons D. Dickkopf-1 antagonizes Wnt signaling independent of beta-catenin in human mesothelioma. Biochem Biophys Res Commun. 2004 Oct 29; 323(4):1246-50. PMID: 15451431.
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    163. Reguart N, He B, Xu Z, You L, Lee AY, Mazieres J, Mikami I, Batra S, Rosell R, McCormick F, Jablons D. Cloning and characterization of the promoter of human Wnt inhibitory factor-1. Biochem Biophys Res Commun. 2004 Oct 08; 323(1):229-34. PMID: 15351726.
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    164. Lee AY, He B, You L, Dadfarmay S, Xu Z, Mazieres J, Mikami I, McCormick F, Jablons D. Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma. Oncogene. 2004 Aug 26; 23(39):6672-6. PMID: 15221014.
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    165. You L, He B, Xu Z, Uematsu K, Mazieres J, Mikami I, Reguart N, Moody TW, Kitajewski J, McCormick F, Jablons D. Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells. Oncogene. 2004 Aug 12; 23(36):6170-4. PMID: 15208662.
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    166. Beseth BD, Cameron RB, Leland P, You L, Varricchio F, Kreitman RJ, Maki RA, Jablons D, Husain SR, Puri RK. Interleukin-4 receptor cytotoxin as therapy for human malignant pleural mesothelioma xenografts. Ann Thorac Surg. 2004 Aug; 78(2):436-43; discussion 436-43. PMID: 15276492.
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    167. You L, He B, Xu Z, Uematsu K, Mazieres J, Fujii N, Mikami I, Reguart N, McIntosh JK, Kashani-Sabet M, McCormick F, Jablons D. An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth. Cancer Res. 2004 Aug 01; 64(15):5385-9. PMID: 15289346.
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    168. Mazieres J, He B, You L, Xu Z, Lee AY, Mikami I, Reguart N, Rosell R, McCormick F, Jablons D. Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer. Cancer Res. 2004 Jul 15; 64(14):4717-20. PMID: 15256437.
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    169. Johnson DH, Fehrenbacher L, Novotny WF, Herbst RS, Nemunaitis JJ, Jablons D, Langer CJ, DeVore RF, Gaudreault J, Damico LA, Holmgren E, Kabbinavar F. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol. 2004 Jun 01; 22(11):2184-91. PMID: 15169807.
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    170. You L, He B, Uematsu K, Xu Z, Mazieres J, Lee A, McCormick F, Jablons D. Inhibition of Wnt-1 signaling induces apoptosis in beta-catenin-deficient mesothelioma cells. Cancer Res. 2004 May 15; 64(10):3474-8. PMID: 15150100.
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    171. He B, You L, Xu Z, Mazieres J, Lee AY, Jablons D. Activity of the suppressor of cytokine signaling-3 promoter in human non-small-cell lung cancer. Clin Lung Cancer. 2004 May; 5(6):366-70. PMID: 15217536.
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    172. Nemunaitis J, Sterman D, Jablons D, Smith JW, Fox B, Maples P, Hamilton S, Borellini F, Lin A, Morali S, Hege K. Granulocyte-macrophage colony-stimulating factor gene-modified autologous tumor vaccines in non-small-cell lung cancer. J Natl Cancer Inst. 2004 Feb 18; 96(4):326-31. PMID: 14970281.
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    173. Mann MJ, Kramer MJ, Hall TS, Anastassiou P, Katz J, Golden J, Jones K, Jablons D. Isolated pulmonary arteriovenous malformations requiring anatomic resection. J Thorac Cardiovasc Surg. 2004 Feb; 127(2):574-6. PMID: 14762372.
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    174. You L, He B, Xu Z, McCormick F, Jablons D. Future directions: oncolytic viruses. Clin Lung Cancer. 2004 Jan; 5(4):226-30. PMID: 14967074.
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    175. Corvera CU, Jablons D, Morita E, Clark OH. Retrocardiac parathyroid tumor: a rare mediastinal site. Surgery. 2004 Jan; 135(1):104-7. PMID: 14694307.
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    176. Wang ZJ, Reddy GP, Gotway MB, Higgins CB, Jablons D, Ramaswamy M, Hawkins RA, Webb WR. Malignant pleural mesothelioma: evaluation with CT, MR imaging, and PET. Radiographics. 2004 Jan-Feb; 24(1):105-19. PMID: 14730040.
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    177. He B, You L, Uematsu K, Xu Z, Lee AY, Matsangou M, McCormick F, Jablons D. A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia. 2004 Jan-Feb; 6(1):7-14. PMID: 15068666; PMCID: PMC1508626.
    178. Maslyar DJ, Jahan TM, Jablons D. Mechanisms of and potential treatment strategies for metastatic disease in non-small cell lung cancer. Semin Thorac Cardiovasc Surg. 2004; 16(1):40-50. PMID: 15366686.
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    179. He B, You L, Uematsu K, Zang K, Xu Z, Lee AY, Costello JF, McCormick F, Jablons D. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14133-8. PMID: 14617776; PMCID: PMC283558.
    180. Uematsu K, He B, You L, Xu Z, McCormick F, Jablons D. Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression. Oncogene. 2003 Oct 16; 22(46):7218-21. PMID: 14562050.
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    181. Carter YM, Jablons D, DuBois JB, Thomas CR. Intraoperative radiation therapy in the multimodality approach to upper aerodigestive tract cancer. Surg Oncol Clin N Am. 2003 Oct; 12(4):1043-63. PMID: 14989132.
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    182. Goer DA, Musslewhite CW, Jablons D. Potential of mobile intraoperative radiotherapy technology. Surg Oncol Clin N Am. 2003 Oct; 12(4):943-54. PMID: 14989125.
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    183. Fjellbirkeland L, Cambier S, Broaddus VC, Hill A, Brunetta P, Dolganov G, Jablons D, Nishimura SL. Integrin alphavbeta8-mediated activation of transforming growth factor-beta inhibits human airway epithelial proliferation in intact bronchial tissue. Am J Pathol. 2003 Aug; 163(2):533-42. PMID: 12875973; PMCID: PMC1868219.
    184. Horvai AE, Li L, Xu Z, Kramer MJ, Jablons D, Treseler PA. c-Kit is not expressed in malignant mesothelioma. Mod Pathol. 2003 Aug; 16(8):818-22. PMID: 12920227.
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    185. Uematsu K, Kanazawa S, You L, He B, Xu Z, Li K, Peterlin BM, McCormick F, Jablons D. Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin. Cancer Res. 2003 Aug 01; 63(15):4547-51. PMID: 12907630.
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    186. Jablons D, Cheng SJ, Carolyn Clary-Macy RN, Hirsch FR. 1st International Lung Cancer Conference in Beijing, October 27-30, 2002. Lung Cancer. 2003 Aug; 41(2):237-44. PMID: 12871790.
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    187. Jensen RH, Tiirikainen M, You L, Ginzinger D, He B, Uematsu K, Xu Z, Treseler P, McCormick F, Jablons D. Genomic alterations in human mesothelioma including high resolution mapping of common regions of DNA loss in chromosome arm 6q. Anticancer Res. 2003 May-Jun; 23(3B):2281-9. PMID: 12894504.
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    188. Horvai AE, Li L, Xu Z, Kramer MJ, Jablons D, Treseler PA. Malignant mesothelioma does not demonstrate overexpression or gene amplification despite cytoplasmic immunohistochemical staining for c-Erb-B2. Arch Pathol Lab Med. 2003 Apr; 127(4):465-9. PMID: 12683876.
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    189. He B, You L, Uematsu K, Matsangou M, Xu Z, He M, McCormick F, Jablons D. Cloning and characterization of a functional promoter of the human SOCS-3 gene. Biochem Biophys Res Commun. 2003 Feb 07; 301(2):386-91. PMID: 12565872.
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    190. Yang CT, You L, Lin YC, Lin CL, Mccormick F, Jablons D. A comparison analysis of anti-tumor efficacy of adenoviral gene replacement therapy (p14ARF and p16INK4A) in human mesothelioma cells. Anticancer Res. 2003 Jan-Feb; 23(1A):33-8. PMID: 12680192.
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    191. Brevetti GR, O'Brien B, Coomer CL, Hall TS, Brevetti LS, Jablons D. Emergent surgery for massive pulmonary embolism on the basis of clinical diagnosis. Tex Heart Inst J. 2003; 30(2):149-51. PMID: 12809261; PMCID: PMC161905.
    192. Lim M, Jablons D. Matrix metalloproteinase expression in lung cancer. Methods Mol Med. 2003; 74:349-56. PMID: 12415707.
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    193. Lee TT, Everett DL, Shu HK, Jahan TM, Roach M, Speight JL, Cameron RB, Phillips TL, Chan A, Jablons D. Radical pleurectomy/decortication and intraoperative radiotherapy followed by conformal radiation with or without chemotherapy for malignant pleural mesothelioma. J Thorac Cardiovasc Surg. 2002 Dec; 124(6):1183-9. PMID: 12447185.
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    194. Malik S, Shapiro WA, Jablons D, Katz JA. Contralateral tension pneumothorax during one-lung ventilation for lobectomy: diagnosis aided by fiberoptic bronchoscopy. Anesth Analg. 2002 Sep; 95(3):570-2, table of contents. PMID: 12198039.
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    195. Massion PP, Kuo WL, Stokoe D, Olshen AB, Treseler PA, Chin K, Chen C, Polikoff D, Jain AN, Pinkel D, Albertson DG, Jablons D, Gray JW. Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: implications of the phosphatidylinositol 3-kinase pathway. Cancer Res. 2002 Jul 01; 62(13):3636-40. PMID: 12097266.
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    196. Xia C, Xu Z, Yuan X, Uematsu K, You L, Li K, Li L, McCormick F, Jablons D. Induction of apoptosis in mesothelioma cells by antisurvivin oligonucleotides. Mol Cancer Ther. 2002 Jul; 1(9):687-94. PMID: 12479365.
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