Loading...

David Wilson, MD, PhD

TitleAssociate Professor
InstitutionUniversity of California San Francisco
DepartmentRadiology
Address185 Berry Street Bldg B
San Francisco CA 94158
Phone415-353-1668
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Columbia University, New YorkM.D.2004School of Medicine
    Columbia University, New YorkPh.D.
    University of California, San FranciscoResidency School of Medicine - Radiology
    University of California, San FranciscoFellowshipSchool of Medicine - Radiology
    Collapse Awards and Honors
    University of California, San Francisco2009Margulis Society Research Award
    Radiological Society of North America2009Resident/Fellowship Research Grant
    National Institutes of Health2007Resident Training Grant Award (NIBIB)
    2004Spotnitz Award for Excellence in Research of Neoplastic Diseases
    Harvard University1996Magna Cum Laude, Biochemistry

    Collapse Overview 
    Collapse Overview
    David M. Wilson, M.D., Ph.D., is an Associate Professor in Residence in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Wilson received his M.D. and Ph.D. from Columbia University in New York, and completed his residency in Diagnostic Radiology at the University of California, San Francisco in 2009, followed by a fellowship in Neuroradiology at UCSF in 2010.

    Dr. Wilson’s research interest is the development of new molecular probes for brain and tumor imaging. He is mainly interested in molecular imaging approaches where structural and biochemical insight is required. Recently, Dr. Wilson’s research consist of the development of new agents for hyperpolarized 13C spectroscopy, and his goal is to identify positron emission tomography (PET) that correlates for imaging in animal models.

    Dr. Wilson is a physician-scientist dedicated to exploring a variety of metabolic and biochemical phenomena using new imaging techniques. His laboratory is currently focusing on comparing hyperpolarized (HP) 13C MRS and positron emission tomography (PET) in a variety of disease processes.

    Expertise:
    Neuroradiology

    Specialty:
    Positron emission tomography (PET)

    Professional Interests:
    Molecular imaging, MR spectroscopy, Redox chemistry, Vitamin C

    Education and Training:
    • Medical School: Columbia University, New York
    • Internship: University of Hawaii Residency Program - Transitional Program
    • Residency: University of California, San Francisco - Diagnostic Radiology
    • Fellowship: University of California, San Francisco - Neuroradiology
    • Doctor of Philosophy: Columbia University, New York


    Collapse Research 
    Collapse Research Activities and Funding
    Development of 11C-PABA as a bacteria-specific imaging agent for spinal infections
    NIH/NIBIB R01EB025985May 1, 2018 - Jan 31, 2022
    Role: Principal Investigator
    Clinical translation of D-amino acid derived PET tracers for imaging spinalinfection
    NIH/NIBIB R01EB024014Sep 20, 2017 - Jun 30, 2021
    Role: Principal Investigator
    Ascorbate-based biomarkers for predicting radiation response in prostate cancer
    NIH/NCI R01CA166766Apr 24, 2012 - Mar 31, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Qin H, Carroll VN, Sriram R, Villanueva-Meyer JE, von Morze C, Wang ZJ, Mutch CA, Keshari KR, Flavell RR, Kurhanewicz J, Wilson D. Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes. Sci Rep. 2018 May 21; 8(1):7928. PMID: 29786697.
      View in: PubMed
    2. Taglang C, Korenchan DE, von Morze C, Yu J, Najac C, Wang S, Blecha JE, Subramaniam S, Bok R, VanBrocklin HF, Vigneron DB, Ronen SM, Sriram R, Kurhanewicz J, Wilson D, Flavell RR. Late-stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI. Chem Commun (Camb). 2018 May 17; 54(41):5233-5236. PMID: 29726563.
      View in: PubMed
    3. Li M, Yang X, Lu X, Dai N, Zhang S, Cheng Y, Zhang L, Yang Y, Liu Y, Yang Z, Wang D, Wilson D. APE1 deficiency promotes cellular senescence and premature aging features. Nucleic Acids Res. 2018 May 10. PMID: 29750271.
      View in: PubMed
    4. Mutch CA, Ordonez AA, Qin H, Parker M, Bambarger LE, Villanueva-Meyer JE, Blecha J, Carroll V, Taglang C, Flavell R, Sriram R, VanBrocklin H, Rosenberg O, Ohliger MA, Jain SK, Neumann KD, Wilson D. [11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism. ACS Infect Dis. 2018 May 08. PMID: 29712422.
      View in: PubMed
    5. Truillet C, Parker MFL, Huynh LT, Wei J, Jami KM, Wang YH, Shen YS, Sriram R, Wilson D, Kurhanewicz J, Evans MJ. Measuring glucocorticoid receptor expression in vivo with PET. Oncotarget. 2018 Apr 17; 9(29):20399-20408. PMID: 29755660.
      View in: PubMed
    6. Dumont RA, Keen NN, Bloomer CW, Schwartz BS, Talbott J, Clark AJ, Wilson D, Chin CT. Clinical Utility of Diffusion-Weighted Imaging in Spinal Infections. Clin Neuroradiol. 2018 Mar 26. PMID: 29582111.
      View in: PubMed
    7. von Morze C, Ohliger MA, Marco-Rius I, Wilson D, Flavell RR, Pearce D, Vigneron DB, Kurhanewicz J, Wang ZJ. Direct assessment of renal mitochondrial redox state using hyperpolarized 13 C-acetoacetate. Magn Reson Med. 2018 Apr; 79(4):1862-1869. PMID: 29314217.
      View in: PubMed
    8. Neumann KD, Villanueva-Meyer JE, Mutch CA, Flavell RR, Blecha JE, Kwak T, Sriram R, VanBrocklin HF, Rosenberg OS, Ohliger MA, Wilson D. Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers. Sci Rep. 2017 Aug 11; 7(1):7903. PMID: 28801560.
      View in: PubMed
    9. Huo E, Wilson D, Eisenmenger L, Hope TA. The Role of PET/MR Imaging in Precision Medicine. PET Clin. 2017 Oct; 12(4):489-501. PMID: 28867118.
      View in: PubMed
    10. Baligand C, Qin H, True-Yasaki A, Gordon JW, von Morze C, Santos JD, Wilson D, Raffai R, Cowley PM, Baker AJ, Kurhanewicz J, Lovett DH, Wang ZJ. Hyperpolarized 13 C magnetic resonance evaluation of renal ischemia reperfusion injury in a murine model. NMR Biomed. 2017 Oct; 30(10). PMID: 28708304.
      View in: PubMed
    11. Neumann K, Flavell R, Wilson D. Exploring Metabolism In Vivo Using Endogenous 11C Metabolic Tracers. Semin Nucl Med. 2017 Sep; 47(5):461-473. PMID: 28826521.
      View in: PubMed
    12. Wilson D, Di Gialleonardo V, Wang ZJ, Carroll V, Von Morze C, Taylor A, Sai V, VanCriekinge M, Bok R, Ohliger MA, Keshari KR. Hyperpolarized 13C Spectroscopic Evaluation of Oxidative Stress in a Rodent Model of Steatohepatitis. Sci Rep. 2017 Apr 20; 7:46014. PMID: 28425467.
      View in: PubMed
    13. Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HJ, Miller BL, Dillon WP, Wilson D, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. PLoS Med. 2017 Mar; 14(3):e1002258. PMID: 28323831.
      View in: PubMed
    14. Aboian MS, Yu JF, Gautam A, Sze CH, Yang JK, Chan J, Lillaney PV, Jordan CD, Oh HJ, Wilson D, Patel AS, Wilson MW, Hetts SW. In vitro clearance of doxorubicin with a DNA-based filtration device designed for intravascular use with intra-arterial chemotherapy. Biomed Microdevices. 2016 12; 18(6):98. PMID: 27778226.
      View in: PubMed
    15. Yokoyama JS, Wang Y, Schork AJ, Thompson WK, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen CH, Holland D, Brewer JB, Franke A, Dillon WP, Wilson D, Mukherjee P, Hess CP, Miller Z, Bonham LW, Shen J, Rabinovici GD, Rosen HJ, Miller BL, Hyman BT, Schellenberg GD, Karlsen TH, Andreassen OA, Dale AM, Desikan RS. Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease. JAMA Neurol. 2016 Jun 01; 73(6):691-7. PMID: 27088644.
      View in: PubMed
    16. Carroll VN, Truillet C, Shen B, Flavell RR, Shao X, Evans MJ, VanBrocklin HF, Scott PJ, Chin FT, Wilson D. [(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography. Chem Commun (Camb). 2016 Apr 07; 52(27):4888-90. PMID: 26963495; PMCID: PMC4854297 [Available on 04/07/17].
    17. Sriram R, Van Criekinge M, DeLos Santos J, Keshari KR, Wilson D, Peehl D, Kurhanewicz J, Wang ZJ. Non-invasive differentiation of benign renal tumors from clear cell renal cell carcinomas using clinically translatable hyperpolarized 13C pyruvate magnetic resonance. Tomography. 2016 Mar; 2(1):35-42. PMID: 27227168.
      View in: PubMed
    18. Korenchan DE, Flavell RR, Baligand C, Sriram R, Neumann K, Sukumar S, VanBrocklin H, Vigneron DB, Wilson D, Kurhanewicz J. Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging. Chem Commun (Camb). 2016 Feb 18; 52(14):3030-3. PMID: 26792559; PMCID: PMC4864526 [Available on 02/09/17].
    19. Di Gialleonardo V, Wilson D, Keshari KR. The Potential of Metabolic Imaging. Semin Nucl Med. 2016 Jan; 46(1):28-39. PMID: 26687855; PMCID: PMC4686865 [Available on 01/01/17].
    20. Flavell RR, Truillet C, Regan MK, Ganguly T, Blecha JE, Kurhanewicz J, VanBrocklin HF, Keshari KR, Chang CJ, Evans MJ, Wilson D. Caged [(18)F]FDG Glycosylamines for Imaging Acidic Tumor Microenvironments Using Positron Emission Tomography. Bioconjug Chem. 2016 Jan 20; 27(1):170-8. PMID: 26649808; PMCID: PMC4854293.
    21. Flavell RR, von Morze C, Blecha JE, Korenchan DE, Van Criekinge M, Sriram R, Gordon JW, Chen HY, Subramaniam S, Bok RA, Wang ZJ, Vigneron DB, Larson PE, Kurhanewicz J, Wilson D. Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI. Chem Commun (Camb). 2015 Sep 25; 51(74):14119-22. PMID: 26257040; PMCID: PMC4854286.
    22. Brown JD, Saeed M, Do L, Braz J, Basbaum AI, Iadarola MJ, Wilson D, Dillon WP. CT-guided injection of a TRPV1 agonist around dorsal root ganglia decreases pain transmission in swine. Sci Transl Med. 2015 Sep 16; 7(305):305ra145. PMID: 26378245; PMCID: PMC4854290.
    23. Sriram R, Van Criekinge M, Hansen A, Wang ZJ, Vigneron DB, Wilson D, Keshari KR, Kurhanewicz J. Real-time measurement of hyperpolarized lactate production and efflux as a biomarker of tumor aggressiveness in an MR compatible 3D cell culture bioreactor. NMR Biomed. 2015 Sep; 28(9):1141-9. PMID: 26202449; PMCID: PMC4537810.
    24. Keshari KR, Wilson D, Van Criekinge M, Sriram R, Koelsch BL, Wang ZJ, VanBrocklin HF, Peehl DM, O'Brien T, Sampath D, Carano RA, Kurhanewicz J. Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor. Prostate. 2015 Oct; 75(14):1601-9. PMID: 26177608; PMCID: PMC4537380 [Available on 10/01/16].
    25. Keshari KR, Wilson D, Sai V, Bok R, Jen KY, Larson P, Van Criekinge M, Kurhanewicz J, Wang ZJ. Noninvasive in vivo imaging of diabetes-induced renal oxidative stress and response to therapy using hyperpolarized 13C dehydroascorbate magnetic resonance. Diabetes. 2015 Feb; 64(2):344-52. PMID: 25187363; PMCID: PMC4303960.
    26. Wilson D, Kurhanewicz J. Hyperpolarized 13C MR for molecular imaging of prostate cancer. J Nucl Med. 2014 Oct; 55(10):1567-72. PMID: 25168625; PMCID: PMC4349324.
    27. Yu JP, Wilson D, Chang EF, Cotter J, Perry A, Mahindra A, Glastonbury CM. Isolated intracerebral light chain deposition disease: novel imaging and pathologic findings. Clin Imaging. 2014 Nov-Dec; 38(6):868-71. PMID: 25084689; PMCID: PMC4854295.
    28. Keshari KR, Wilson D. Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization. Chem Soc Rev. 2014 Mar 07; 43(5):1627-59. PMID: 24363044; PMCID: PMC4086923.
    29. Wilson D, Cohen B, Keshari K, Vogel H, Steinberg G, Dillon W. Case report: glioblastoma multiforme complicating familial cavernous malformations. Clin Neuroradiol. 2014 Sep; 24(3):293-6. PMID: 23942770.
      View in: PubMed
    30. Keshari KR, Sai V, Wang ZJ, Vanbrocklin HF, Kurhanewicz J, Wilson D. Hyperpolarized [1-13C]dehydroascorbate MR spectroscopy in a murine model of prostate cancer: comparison with 18F-FDG PET. J Nucl Med. 2013 Jun; 54(6):922-8. PMID: 23575993; PMCID: PMC3682497.
    31. Keshari KR, Sriram R, Van Criekinge M, Wilson D, Wang ZJ, Vigneron DB, Peehl DM, Kurhanewicz J. Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor. Prostate. 2013 Aug; 73(11):1171-81. PMID: 23532911; PMCID: PMC3976546.
    32. Koelsch BL, Keshari KR, Peeters TH, Larson PE, Wilson D, Kurhanewicz J. Diffusion MR of hyperpolarized 13C molecules in solution. Analyst. 2013 Feb 21; 138(4):1011-4. PMID: 23304699; PMCID: PMC3568999.
    33. Keshari KR, Sriram R, Koelsch BL, Van Criekinge M, Wilson D, Kurhanewicz J, Wang ZJ. Hyperpolarized 13C-pyruvate magnetic resonance reveals rapid lactate export in metastatic renal cell carcinomas. Cancer Res. 2013 Jan 15; 73(2):529-38. PMID: 23204238; PMCID: PMC3548990.
    34. Keshari KR, Kurhanewicz J, Macdonald JM, Wilson D. Generating contrast in hyperpolarized 13C MRI using ligand-receptor interactions. Analyst. 2012 Aug 07; 137(15):3427-9. PMID: 22655289; PMCID: PMC3600417.
    35. Keshari KR, Kurhanewicz J, Bok R, Larson PE, Vigneron DB, Wilson D. Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18606-11. PMID: 22042839; PMCID: PMC3219134.
    36. Hu S, Zhu M, Yoshihara HA, Wilson D, Keshari KR, Shin P, Reed G, von Morze C, Bok R, Larson PE, Kurhanewicz J, Vigneron DB. In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanine. Magn Reson Imaging. 2011 Oct; 29(8):1035-40. PMID: 21855243; PMCID: PMC3172390.
    37. von Morze C, Larson PE, Hu S, Keshari K, Wilson D, Ardenkjaer-Larsen JH, Goga A, Bok R, Kurhanewicz J, Vigneron DB. Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models. J Magn Reson Imaging. 2011 Mar; 33(3):692-7. PMID: 21563254; PMCID: PMC3566235.
    38. Wilson D, Keshari KR, Larson PE, Chen AP, Hu S, Van Criekinge M, Bok R, Nelson SJ, Macdonald JM, Vigneron DB, Kurhanewicz J. Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo. J Magn Reson. 2010 Jul; 205(1):141-7. PMID: 20478721; PMCID: PMC2885774.
    39. Keshari KR, Kurhanewicz J, Jeffries RE, Wilson D, Dewar BJ, Van Criekinge M, Zierhut M, Vigneron DB, Macdonald JM. Hyperpolarized (13)C spectroscopy and an NMR-compatible bioreactor system for the investigation of real-time cellular metabolism. Magn Reson Med. 2010 Feb; 63(2):322-9. PMID: 20099325; PMCID: PMC2829258.
    40. Keshari KR, Wilson D, Chen AP, Bok R, Larson PE, Hu S, Van Criekinge M, Macdonald JM, Vigneron DB, Kurhanewicz J. Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging. J Am Chem Soc. 2009 Dec 09; 131(48):17591-6. PMID: 19860409; PMCID: PMC2796621.
    41. Wilson D, Hurd RE, Keshari K, Van Criekinge M, Chen AP, Nelson SJ, Vigneron DB, Kurhanewicz J. Generation of hyperpolarized substrates by secondary labeling with [1,1-13C] acetic anhydride. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5503-7. PMID: 19276112; PMCID: PMC2654026.
    42. Baugh SD, Yang Z, Leung DK, Wilson D, Breslow R. Cyclodextrin dimers as cleavable carriers of photodynamic sensitizers. J Am Chem Soc. 2001 Dec 19; 123(50):12488-94. PMID: 11741411.
      View in: PubMed