David Wilson, MD, PhD

Title(s)Professor, Radiology
SchoolSchool of Medicine
Address185 Berry Street Bldg B, #184
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    Columbia University, New YorkM.D.2004School of Medicine
    Columbia University, New YorkPh.D.
    University of California, San FranciscoResidency School of Medicine - Radiology
    University of California, San FranciscoFellowshipSchool of Medicine - Radiology
    Collapse Awards and Honors
    University of California, San Francisco2009Margulis Society Research Award
    Radiological Society of North America2009Resident/Fellowship Research Grant
    National Institutes of Health2007Resident Training Grant Award (NIBIB)
    2004Spotnitz Award for Excellence in Research of Neoplastic Diseases
    Harvard University1996Magna Cum Laude, Biochemistry

    Collapse Overview 
    Collapse Overview
    David M. Wilson, M.D., Ph.D. received his B.S. degree from Harvard University in Biochemistry, and completed his M.D./Ph.D. training at Columbia University in New York City. His Ph.D. mentor was Dr. Ronald Breslow, a pioneer in artificial enzymes, the hydrophobic effect, and bio-organic chemistry. Dr. Wilson’s subsequent clinical training was in radiology and neuroradiology at University of California, San Francisco (UCSF), where he trained further in the laboratory of Professor John Kurhanewicz and subsequently became a faculty member in 2010. He has since established a basic science laboratory investigating the detection and characterization of cancer via analyte sensing, and developing probes for positron emission tomography (PET) and hyperpolarized 13C spectroscopy. His laboratory has most recently studied imaging infection using bacteria-specific metabolic pathways, and ways to detect ACE2 suppression in SARS-CoV-2.

    Dr. Wilson’s research interest is the development of new molecular probes for brain and tumor imaging. He is mainly interested in molecular imaging approaches where structural and biochemical insight is required. Recently, Dr. Wilson’s research consist of the development of new agents for hyperpolarized 13C spectroscopy, and his goal is to identify positron emission tomography (PET) that correlates for imaging in animal models.

    Dr. Wilson is a physician-scientist dedicated to exploring a variety of metabolic and biochemical phenomena using new imaging techniques. His laboratory is currently focusing on comparing hyperpolarized (HP) 13C MRS and positron emission tomography (PET) in a variety of disease processes.


    Positron emission tomography (PET)

    Professional Interests:
    Molecular imaging, MR spectroscopy, Redox chemistry, Vitamin C

    Education and Training:
    • Medical School: Columbia University, New York
    • Internship: University of Hawaii Residency Program - Transitional Program
    • Residency: University of California, San Francisco - Diagnostic Radiology
    • Fellowship: University of California, San Francisco - Neuroradiology
    • Doctor of Philosophy: Columbia University, New York

    Collapse Research 
    Collapse Research Activities and Funding
    ACE2-targeted PET radiotracers for investigating spatiotemporal distribution of SARS-CoV-2 organ injury and therapy response.
    NIH R01AI161829Sep 17, 2021 - Aug 31, 2024
    Role: Principal Investigator
    Diagnosis of low-grade glial tumors using 11C glutamine isotopomers
    NIH R21EB030899Aug 1, 2021 - May 31, 2023
    Role: Co-Principal Investigator
    Imaging bacterial infection using deuterium-enriched sugar alcohols.
    NIH R21AI164684Jun 15, 2021 - May 31, 2023
    Role: Principal Investigator
    Sensing living P. aeruginosa using D-alanine derived radiotracers
    NIH R01EB030897May 1, 2021 - Jan 31, 2025
    Role: Principal Investigator
    New radiotracer development to study immune cell mobilization of granzyme proteolytic activity
    NIH R01AI161027Apr 20, 2021 - Mar 31, 2025
    Role: Co-Principal Investigator
    Development of 11C-PABA as a bacteria-specific imaging agent for spinal infections
    NIH R01EB025985May 1, 2018 - Aug 31, 2022
    Role: Principal Investigator
    Clinical translation of D-amino acid derived PET tracers for imaging spinalinfection
    NIH R01EB024014Sep 20, 2017 - Jun 30, 2021
    Role: Principal Investigator
    Ascorbate-based biomarkers for predicting radiation response in prostate cancer
    NIH R01CA166766Apr 24, 2012 - Mar 31, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Peptidoglycan-Targeted [18F]3,3,3-Trifluoro-d-alanine Tracer for Imaging Bacterial Infection. JACS Au. 2024 Feb 25. Sorlin SA, Lo´pez-A´lvarez LM, Biboy BJ, Gray GJ, Rabbitt RS, Rahim RJ, Lee LS, Bobba BK, Blecha BJ, Parker PM, Flavell FR, Engel EJ, Ohliger OM, Vollmer VW, Wilson WD. .
      View in: Publisher Site   Mentions:
    2. P-045 First in-human studies of the glutamate transporter EAAT2 radiotracer methyl N4-(7-[18F]fluoro-9H-fluoren-2-yl)asparginate (RP-115): radiosynthesis and biodistribution evaluation. Nuclear Medicine and Biology. 2023 Nov 1; 126:108517. Nillo NR, Blecha BJ, Chao CC, Seo SY, Forsayeth FJ, Gerdes GJ, VanBrocklin VH, Wilson WD. .
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    3. O-14 Evaluation of 134Ce/La pair as a PET imaging surrogate for 225Ac radiotherapeutics. Nuclear Medicine and Biology. 2023 Nov 1; 126:108410. Bobba BK, Bidkar BA, Meher MN, Fong FC, Wadhwa WA, Dhrona DS, Sorlin SA, Bidlingmaier BS, Shuere SB, He HJ, Wilson WD, Liu LB, Seo SY, VanBrocklin VH, Flavell FR. .
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    4. O-04 StarPEG Nanocarriers for PSMA Targeted Radioligand Imaging and Therapy. Nuclear Medicine and Biology. 2023 Nov 1; 126:108400. Bidkar BA, Meher MN, Ashley AG, Wadhwa WA, Bobba BK, Shuere SB, Wilson WD, Seo SY, Santi SD, VanBrocklin VH, Flavell FR. .
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    5. Nuclear imaging of bacterial infection: the state of the art and future directions. Chinese Journal of Nuclear Medicine and Molecular Imaging. 2022 Jul 25; 42(07):436-444. Polvoy PI, Flavell FR, Rosenberg RO, Ohliger OM, Wilson WD. .
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    6. In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET. ACS Central Science. 2021 Sep 2. Zhao ZN, Bardine BC, Lourenc¸o LA, Wang WY, Huang HY, Cleary CS, Wilson WD, Oh OD, Fong FL, Looney LM, Evans EM, Craik CC. .
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    7. Deuterium Metabolic Imaging—Rediscovery of a Spectroscopic Tool. Metabolites. 2021 Aug 25; 11(9):570. Polvoy PI, Qin QH, Flavell FR, Gordon GJ, Viswanath VP, Sriram SR, Ohliger OM, Wilson WD. .
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    8. Synthesis of N-trifluoromethyl amides from carboxylic acids. Chem. 2021 Aug 1; 7(8):2245-2255. Liu LJ, Parker PM, Wang WS, Flavell FR, Toste TF, Wilson WD. .
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    9. Introduction: MRI/MRS as Metabolic Imaging Tools. Imaging and Metabolism. 2018 Jan 1; 81-98. Wilson WD, Ohliger OM. .
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    10. Bacterial Imaging. Imaging Infections. 2017 Jan 1; 149-172. Ordonez OA, Bambarger BL, Murthy MN, Wilson WD, Jain JS. .
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    11. Recent Developments in Combined PET/MRI. Current Radiology Reports. 2016 May 1; 4(5):22. Flavell FR, Wilson WD, Behr BS. .
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    12. [(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography. Chem Commun (Camb). 2016 Apr 07; 52(27):4888-90. Carroll VN, Truillet C, Shen B, Flavell RR, Shao X, Evans MJ, VanBrocklin HF, Scott PJ, Chin FT, Wilson DM. PMID: 26963495; PMCID: PMC4854297.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    13. Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging. Chem Commun (Camb). 2016 Feb 18; 52(14):3030-3. Korenchan DE, Flavell RR, Baligand C, Sriram R, Neumann K, Sukumar S, VanBrocklin H, Vigneron DB, Wilson DM, Kurhanewicz J. PMID: 26792559; PMCID: PMC4864526.
      View in: PubMed   Mentions: 20     Fields:    
    14. Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI. Chem Commun (Camb). 2015 Sep 25; 51(74):14119-22. Flavell RR, von Morze C, Blecha JE, Korenchan DE, Van Criekinge M, Sriram R, Gordon JW, Chen HY, Subramaniam S, Bok RA, Wang ZJ, Vigneron DB, Larson PE, Kurhanewicz J, Wilson DM. PMID: 26257040; PMCID: PMC4854286.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    15. Abstract B37: Patient-derived tissue culture model systems of renal cell carcinoma for development of clinically translatable metabolic biomarkers. Preclinical Studies. 2014 Nov 1; b37-b37. Sriram SR, Keshari KK, Criekinge CM, Kurhanewicz KJ, Wilson WD, Peehl PD, Bok BR, Zhen ZW. .
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    16. ChemInform Abstract: Chemistry and Biochemistry of 13C Hyperpolarized Magnetic Resonance Using Dynamic Nuclear Polarization. ChemInform. 2014 May 6; 45(18):no-no. Keshari KK, Wilson WD. .
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    17. Case report: glioblastoma multiforme complicating familial cavernous malformations. Clin Neuroradiol. 2014 Sep; 24(3):293-6. Wilson DM, Cohen B, Keshari K, Vogel H, Steinberg G, Dillon W. PMID: 23942770.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. Solid phase synthesis of hydroxamate peptides for histone deacetylase inhibition. Tetrahedron Letters. 2013 Jan 1; 54(2):151-153. Wilson WD, Silverman SL, Bergauer BM, Keshari KK. .
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    19. Metabolic Profiling of CNS Lymphoma and Its Microenvironment. Blood. 2011 Nov 18; 118(21):588-588. Bet-Lachin BA, Jiang JF, Chen CL, Keshari KK, Wilson WD, Kurhanewicz KJ, Rubenstein RJ. .
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    20. Cyclodextrin dimers as cleavable carriers of photodynamic sensitizers. J Am Chem Soc. 2001 Dec 19; 123(50):12488-94. Baugh SD, Yang Z, Leung DK, Wilson DM, Breslow R. PMID: 11741411.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells