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Region-specific distribution of transversal-axial tubule system organization underlies heterogeneity of calcium dynamics in the right atrium. American Journal of Physiology-Heart and Circulatory Physiology. 2022; 322(2):269-284.
Lang D, * Medvedev RY, Ratajczyk L, Zheng J, Yuan X, Lim E, Han OY, Valdivia HH, Glukhov AV.* *: corresponding author.
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Caveolin-3 prevents swelling-induced membrane damage via regulation of ICI, swell activity. Biophysical Journal. 2022; 9(121):1643-1659.
Turner D, Tyan L, DeGuire F, Medvedev R, Stroebel S, Lang D, Glukhov AV.
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Micropattern platform promotes extracellular matrix remodeling by human PSC‐derived cardiac fibroblasts and enhances contractility of co‐cultured cardiomyocytes. Physiological Reports. 2021; 9(19):15054.
Napiwocki BN, Stempien A, Lang D, Kruepke RA, Kim G, Zhang J, Eckhardt LL, Glukhov AV, Kamp TJ, Crone WC.
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Cellular and molecular mechanisms of functional hierarchy of pacemaker clusters in the sinoatrial node: New insights into sick sinus syndrome. Journal of Cardiovascular Development and Disease. 2021; 8(4):43.
Lang D, Glukhov AV.
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Human iPSC-engineered cardiac tissue platform faithfully models important cardiac physiology. American Journal of Physiology-Heart and Circulatory Physiology. 2021; 320(4):670-686.
de Lange WJ, Farrell ET, Kreitzer CR, Jacobs DR, Lang D, Glukhov AV, Ralphe JC.
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Aligned human cardiac syncytium for in vitro analysis of electrical, structural, and mechanical readouts. Biotechnology and bioengineering. 2021; 118(1):442-452.
Napiwocki BN, Lang D, Stempien A, Zhang J, Vaidyanathan R, Makielski JC, Eckhardt LL, Glukhov AV, Kamp TJ, Crone WC.
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Genetic Loss of I K1 Causes Adrenergic-Induced Phase 3 Early Afterdepolariz ations and Polymorphic and Bidirectional Ventricular Tachycardia. Circulation: Arrhythmia and Electrophysiology. 2020; 13(9):e008638.
Reilly L, Alvarado FJ, Lang D, Abozeid S, Van Ert H, Spellman C, Warden J, Makielski JC, Glukhov AV, Eckhardt LL.
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Cardiomyocyte Microdomains: An Emerging Concept of Local Regulation and Remodeling. Frontiers in Physiology. 2020; 26(11):512.
Lang D, Calaghan SC, Gorelik J, Glukhov AV.
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Induced cardiac progenitor cells repopulate decellularized mouse heart scaffolds and differentiate to generate cardiac tissue. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2020; 1867(3):118559.
lexanian RA, Mahapatra K, Lang D, Vaidyanathan R, Markandeya YS, Gill RK, Zhai AJ, Dhillon A, Lea MR, Abozeid S, Schmuck EG.
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Caveolae‐Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis. Journal of the American Heart Association. 2019; 8(20):e012748.
Egorov YV, * Lang D, * Tyan L, Turner D, Lim E, Piro ZD, Hernandez JJ, Lodin R, Wang R, Schmuck EG, Raval AN, Glukhov AV. *: co-first author.
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Epigenetic priming of human pluripotent stem cell-derived cardiac progenitor cells accelerates cardiomyocyte maturation. Stem Cells. 2019; 37(7):910-923.
Biermann M, Cai W, * Lang D, * Hermsen J, Profio L, Zhou Y, Czirok A, Isai DG, Napiwocki BN, Rodriguez AM, Brown ME, Glukhov AV, Kamp TJ. *: Authors contribute equally.
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Long QT syndrome caveolin‐3 mutations differentially modulate Kv4 and Cav1. 2 channels to contribute to action potential prolongation. The Journal of physiology. 2019; 597(6):1531-1551.
Tyan L, Foell JD, Vincent KP, Woon MT, Mesquitta WT, Lang D, Best JM, Ackerman MJ, McCulloch AD, Glukhov AV, Balijepalli RC, Kamp TJ.
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Functional microdomains in heart’s pacemaker: A step beyond classical electrophysiology and remodeling. Frontiers in physiology. 2018; 27(9):1686.
Lang D, Glukhov AV.
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Calcium-dependent arrhythmogenic foci created by weakly coupled myocytes in the failing heart. Circulation Research. 2017; 121(12):1379-1391.
Lang D, Sato D, Jiang Y, Ginsburg KS, Ripplinger CM, Bers DM.
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β-Adrenergic inhibition prevents action potential and calcium handling changes during regional myocardial ischemia. Frontiers in physiology. 2017; (8):630.
Murphy SR, Wang L, Wang Z, Domondon P, Lang D, Habecker BA, Myles RC, Ripplinger CM.
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An East Asian common variant vinculin P. Asp841His was associated with sudden unexplained nocturnal death syndrome in the Chinese Han population. Journal of the American Heart Association. 2017; 6(4):e005330.
Cheng J, Kyle JW, Lang D, Wiedmeyer B, Guo J, Yin K, Huang L, Vaidyanathan R, Su T, Makielski JC.
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Vinculin variant M94I identified in sudden unexplained nocturnal death syndrome decreases cardiac sodium current. Scientific Reports. 2017; 7(1):1-2.
16. Cheng J, Kyle JW, Wiedmeyer B, Lang D, Vaidyanathan R, Makielski JC.
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High-resolution optical mapping of the mouse sino-atrial node. JoVE. 2016; 2(118):e54773.
Lang D, Glukhov AV.
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Does sudden unexplained nocturnal death syndrome remain the autopsy-negative disorder: a gross, microscopic, and molecular autopsy investigation in Southern China. Mayo Clinic Proceedings. 2016; 91(11):1503-1514.
18. Zhang L, * Tester DJ, * Lang D, * Chen Y, Zheng J, Gao R, Corliss RF, Tang S, Kyle JW, Liu C, Ackerman MJ, Makielski JC, Cheng JD. *: co-first author.
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Arrhythmogenic remodeling of β2 versus β1 adrenergic signaling in the human failing heart. Circulation: Arrhythmia and Electrophysiology. 2015; 8(2):409-419.
Lang D, Holzem K, Kang C, Xiao M, Hwang HJ, Ewald GA, Yamada KA, Efimov IR.
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Junctional cleft [Ca2+] i measurements using novel cleft-targeted Ca2+ sensors. Circulation research. 2014; 115(3):339-347.
Despa S, Shui B, Bossuyt J, Lang D, Kotlikoff MI, Bers DM.
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Multistage electrotherapy delivered through chronically-implanted leads terminates atrial fibrillation with lower energy than a single biphasic shock. Journal of the American College of Cardiology. 2014; 63(1):40-48.
Janardhan AH, Gutbrod SR, Li W, Lang D, Schuessler RB, Efimov IR.
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Manu of Research Techniques in Cardiovascular Medicine. Chapter 7: Optical Mapping of the Heart. 2013.
Lang, D., Gutbrod, S., Laughner, J., Efimov, IR.
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Diabetes increases mortality after myocardial infarction by oxidizing CaMKII. The Journal of clinical investigation. 2013; 123(3):1263-1274.
Luo M, Guan X, Luczak ED, Lang D, Kutschke W, Gao Z, Yang J, Glynn P, Sossalla S, Swaminathan PD, Weiss RM, Anderson M, .
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Right ventricular arrhythmogenesis in failing human heart: the role of conduction and repolarization remodeling. American Journal of Physiology-Heart and Circulatory Physiology. 2012; 303(12):1426-1434.
Lou Q, Janks DL, Holzem KM, Lang D, Onal B, Ambrosi CM, Fedorov VV, Wang IW, Efimov IR.
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Focal but reversible diastolic sheet dysfunction reflects regional calcium mishandling in dystrophic mdx mouse hearts. American Journal of Physiology-Heart and Circulatory Physiology. 2012; 303(5):559-568.
Cheng YJ, * Lang D, * Caruthers SD, Efimov IR, Chen J, Wickline SA. *: co-first author.
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Cardiac Mapping, Ed: M. Shenasa. Chapter 9: Optical Mapping of the SA node and AV node. 2012.
Janardhan, AJ., Lang, D., Efimov, IR.
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Spatiotemporal control of heart rate in a rabbit heart. Journal of electrocardiology. 2011; 44(6):626-634.
Lang D, Petrov V, Lou Q, Osipov G, Efimov IR.
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Role of Pyk2 in cardiac arrhythmogenesis. American Journal of Physiology-Heart and Circulatory Physiology. 2011; 301(3):975-983.
Lang D, Glukhov AV, Efimova T, Efimov IR.
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Optical mapping of action potentials and calcium transients in the mouse heart. JoVE. 2011; 13(55):e3275.
Lang D, Sulkin M, Lou Q, Efimov IR.
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Bi-directional transport of GLUT4 vesicles near the plasma membrane of primary rat adipocytes. Biochemical and biophysical research communications. 2007; 359(1):121-128.
Xu YK, Xu KD, Li JY, Feng LQ, Lang D, Zheng XX.