Di Lang • UCSF Profiles

Di Lang, PhD, MS

Title(s)	Assistant Professor, Medicine
School	School of Medicine
Address	555 Mission Bay Blvd South, #352C San Francisco CA 94158
Phone	415-514-1656
ORCID	0000-0003-3318-4208
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Biography

Education and Training

Washington University in St. Louis	Ph.D.	Biomedical Engineering
University of California Davis		Postdoc in Pharmacology
University of Wisconsin Madison		Scientist in Medicine

Overview

My research interests focus on understanding the membrane nanodomain mediated compartmentalized cellular and molecular functioning and regulation of proteins in the cardiac physiology and pathology and developing therapeutic strategies targeting the cell cytoarchitectures using animal models, primary cardiomyocytes and human induced pluripotent stem cells (hiPSCs).

Interests

Cardiac arrhythmias, sinoatrial node, calcium signaling, heart failure, stem cells

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Cholecystokinin-A Signaling Regulates Automaticity of Pacemaker Cardiomyocytes. bioRxiv. 2023 Aug 28. Ruan H, Mandla R, Ravi N, Galang G, Soe AW, Olgin JE, Lang D, Vedantham V. PMID: 36747643; PMCID: PMC9900793.

View in: PubMed Mentions:
Investigating the composition and recruitment of the mycobacterial ImuA'-ImuB-DnaE2 mutasome. Elife. 2023 08 02; 12. Gessner S, Martin ZA, Reiche MA, Santos JA, Dinkele R, Ramudzuli A, Dhar N, de Wet TJ, Anoosheh S, Lang DM, Aaron J, Chew TL, Herrmann J, Müller R, McKinney JD, Woodgate R, Mizrahi V, Venclovas C, Lamers MH, Warner DF. PMID: 37530405; PMCID: PMC10421592.

View in: PubMed Mentions: 1 Fields:
Bio Biology
Translation:Cells
A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. Elife. 2022 Oct 18; 11. Ding Y, Lang D, Yan J, Bu H, Li H, Jiao K, Yang J, Ni H, Morotti S, Le T, Clark KJ, Port J, Ekker SC, Cao H, Zhang Y, Wang J, Grandi E, Li Z, Shi Y, Li Y, Glukhov AV, Xu X. PMID: 36255053; PMCID: PMC9642998.

View in: PubMed Mentions: 3 Fields:
Bio Biology
Translation:Humans Animals
Beyond Diagnosis: a Novel Microbiota Dependent Biomarker and Target for Atherosclerosis. Circ Res. 2022 08 19; 131(5):421-423. Lang D. PMID: 35981000; PMCID: PMC9395143.

View in: PubMed Mentions: Fields:
Car Cardiology Vas Vascular Diseases
Translation:Humans
Region-specific distribution of transversal-axial tubule system organization underlies heterogeneity of calcium dynamics in the right atrium. American Journal of Physiology-Heart and Circulatory Physiology. 2022; 322(2):269-284. Lang D, * Medvedev RY, Ratajczyk L, Zheng J, Yuan X, Lim E, Han OY, Valdivia HH, Glukhov AV.* *: corresponding author.
Caveolin-3 prevents swelling-induced membrane damage via regulation of ICI, swell activity. Biophysical Journal. 2022; 9(121):1643-1659. Turner D, Tyan L, DeGuire F, Medvedev R, Stroebel S, Lang D, Glukhov AV.
Micropattern platform promotes extracellular matrix remodeling by human PSC‐derived cardiac fibroblasts and enhances contractility of co‐cultured cardiomyocytes. Physiological Reports. 2021; 9(19):15054. Napiwocki BN, Stempien A, Lang D, Kruepke RA, Kim G, Zhang J, Eckhardt LL, Glukhov AV, Kamp TJ, Crone WC.
Cellular and molecular mechanisms of functional hierarchy of pacemaker clusters in the sinoatrial node: New insights into sick sinus syndrome. Journal of Cardiovascular Development and Disease. 2021; 8(4):43. Lang D, Glukhov AV.
Human iPSC-engineered cardiac tissue platform faithfully models important cardiac physiology. American Journal of Physiology-Heart and Circulatory Physiology. 2021; 320(4):670-686. de Lange WJ, Farrell ET, Kreitzer CR, Jacobs DR, Lang D, Glukhov AV, Ralphe JC.
Aligned human cardiac syncytium for in vitro analysis of electrical, structural, and mechanical readouts. Biotechnology and bioengineering. 2021; 118(1):442-452. Napiwocki BN, Lang D, Stempien A, Zhang J, Vaidyanathan R, Makielski JC, Eckhardt LL, Glukhov AV, Kamp TJ, Crone WC.
Genetic Loss of I K1 Causes Adrenergic-Induced Phase 3 Early Afterdepolariz ations and Polymorphic and Bidirectional Ventricular Tachycardia. Circulation: Arrhythmia and Electrophysiology. 2020; 13(9):e008638. Reilly L, Alvarado FJ, Lang D, Abozeid S, Van Ert H, Spellman C, Warden J, Makielski JC, Glukhov AV, Eckhardt LL.
Cardiomyocyte Microdomains: An Emerging Concept of Local Regulation and Remodeling. Frontiers in Physiology. 2020; 26(11):512. Lang D, Calaghan SC, Gorelik J, Glukhov AV.
Induced cardiac progenitor cells repopulate decellularized mouse heart scaffolds and differentiate to generate cardiac tissue. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2020; 1867(3):118559. lexanian RA, Mahapatra K, Lang D, Vaidyanathan R, Markandeya YS, Gill RK, Zhai AJ, Dhillon A, Lea MR, Abozeid S, Schmuck EG.
Caveolae‐Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis. Journal of the American Heart Association. 2019; 8(20):e012748. Egorov YV, * Lang D, * Tyan L, Turner D, Lim E, Piro ZD, Hernandez JJ, Lodin R, Wang R, Schmuck EG, Raval AN, Glukhov AV. *: co-first author.
Epigenetic priming of human pluripotent stem cell-derived cardiac progenitor cells accelerates cardiomyocyte maturation. Stem Cells. 2019; 37(7):910-923. Biermann M, Cai W, * Lang D, * Hermsen J, Profio L, Zhou Y, Czirok A, Isai DG, Napiwocki BN, Rodriguez AM, Brown ME, Glukhov AV, Kamp TJ. *: Authors contribute equally.
Long QT syndrome caveolin‐3 mutations differentially modulate Kv4 and Cav1. 2 channels to contribute to action potential prolongation. The Journal of physiology. 2019; 597(6):1531-1551. Tyan L, Foell JD, Vincent KP, Woon MT, Mesquitta WT, Lang D, Best JM, Ackerman MJ, McCulloch AD, Glukhov AV, Balijepalli RC, Kamp TJ.
Functional microdomains in heart’s pacemaker: A step beyond classical electrophysiology and remodeling. Frontiers in physiology. 2018; 27(9):1686. Lang D, Glukhov AV.
Calcium-dependent arrhythmogenic foci created by weakly coupled myocytes in the failing heart. Circulation Research. 2017; 121(12):1379-1391. Lang D, Sato D, Jiang Y, Ginsburg KS, Ripplinger CM, Bers DM.
β-Adrenergic inhibition prevents action potential and calcium handling changes during regional myocardial ischemia. Frontiers in physiology. 2017; (8):630. Murphy SR, Wang L, Wang Z, Domondon P, Lang D, Habecker BA, Myles RC, Ripplinger CM.
An East Asian common variant vinculin P. Asp841His was associated with sudden unexplained nocturnal death syndrome in the Chinese Han population. Journal of the American Heart Association. 2017; 6(4):e005330. Cheng J, Kyle JW, Lang D, Wiedmeyer B, Guo J, Yin K, Huang L, Vaidyanathan R, Su T, Makielski JC.
Vinculin variant M94I identified in sudden unexplained nocturnal death syndrome decreases cardiac sodium current. Scientific Reports. 2017; 7(1):1-2. 16. Cheng J, Kyle JW, Wiedmeyer B, Lang D, Vaidyanathan R, Makielski JC.
High-resolution optical mapping of the mouse sino-atrial node. JoVE. 2016; 2(118):e54773. Lang D, Glukhov AV.
Does sudden unexplained nocturnal death syndrome remain the autopsy-negative disorder: a gross, microscopic, and molecular autopsy investigation in Southern China. Mayo Clinic Proceedings. 2016; 91(11):1503-1514. 18. Zhang L, * Tester DJ, * Lang D, * Chen Y, Zheng J, Gao R, Corliss RF, Tang S, Kyle JW, Liu C, Ackerman MJ, Makielski JC, Cheng JD. *: co-first author.
Arrhythmogenic remodeling of β2 versus β1 adrenergic signaling in the human failing heart. Circulation: Arrhythmia and Electrophysiology. 2015; 8(2):409-419. Lang D, Holzem K, Kang C, Xiao M, Hwang HJ, Ewald GA, Yamada KA, Efimov IR.
Junctional cleft [Ca2+] i measurements using novel cleft-targeted Ca2+ sensors. Circulation research. 2014; 115(3):339-347. Despa S, Shui B, Bossuyt J, Lang D, Kotlikoff MI, Bers DM.
Multistage electrotherapy delivered through chronically-implanted leads terminates atrial fibrillation with lower energy than a single biphasic shock. Journal of the American College of Cardiology. 2014; 63(1):40-48. Janardhan AH, Gutbrod SR, Li W, Lang D, Schuessler RB, Efimov IR.
Manu of Research Techniques in Cardiovascular Medicine. Chapter 7: Optical Mapping of the Heart. 2013. Lang, D., Gutbrod, S., Laughner, J., Efimov, IR.
Diabetes increases mortality after myocardial infarction by oxidizing CaMKII. The Journal of clinical investigation. 2013; 123(3):1263-1274. Luo M, Guan X, Luczak ED, Lang D, Kutschke W, Gao Z, Yang J, Glynn P, Sossalla S, Swaminathan PD, Weiss RM, Anderson M, .
Right ventricular arrhythmogenesis in failing human heart: the role of conduction and repolarization remodeling. American Journal of Physiology-Heart and Circulatory Physiology. 2012; 303(12):1426-1434. Lou Q, Janks DL, Holzem KM, Lang D, Onal B, Ambrosi CM, Fedorov VV, Wang IW, Efimov IR.
Focal but reversible diastolic sheet dysfunction reflects regional calcium mishandling in dystrophic mdx mouse hearts. American Journal of Physiology-Heart and Circulatory Physiology. 2012; 303(5):559-568. Cheng YJ, * Lang D, * Caruthers SD, Efimov IR, Chen J, Wickline SA. *: co-first author.
Cardiac Mapping, Ed: M. Shenasa. Chapter 9: Optical Mapping of the SA node and AV node. 2012. Janardhan, AJ., Lang, D., Efimov, IR.
Spatiotemporal control of heart rate in a rabbit heart. Journal of electrocardiology. 2011; 44(6):626-634. Lang D, Petrov V, Lou Q, Osipov G, Efimov IR.
Role of Pyk2 in cardiac arrhythmogenesis. American Journal of Physiology-Heart and Circulatory Physiology. 2011; 301(3):975-983. Lang D, Glukhov AV, Efimova T, Efimov IR.
Optical mapping of action potentials and calcium transients in the mouse heart. JoVE. 2011; 13(55):e3275. Lang D, Sulkin M, Lou Q, Efimov IR.
Bi-directional transport of GLUT4 vesicles near the plasma membrane of primary rat adipocytes. Biochemical and biophysical research communications. 2007; 359(1):121-128. Xu YK, Xu KD, Li JY, Feng LQ, Lang D, Zheng XX.