Diane Tang-Liu, PhD

Title(s)Professor, Bioengineering
SchoolSchool of Pharmacy
AddressLocation Required
Varies CA 00000
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    1. ISOPT Clinical Hot Topic Panel Discussion on Ocular Drug Delivery. J Ocul Pharmacol Ther. 2019 10; 35(8):457-465. Kompella UB, Domb A, Urtti A, Jayagopal A, Wilson CG, Tang-Liu D. PMID: 31259643.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures. Mol Pharm. 2013 Feb 04; 10(2):650-63. Dahlin A, Geier E, Stocker SL, Cropp CD, Grigorenko E, Bloomer M, Siegenthaler J, Xu L, Basile AS, Tang-Liu DD, Giacomini KM. PMID: 23268600.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    3. Idiosyncratic reactions and metabolism of sulfur-containing drugs. Expert Opin Drug Metab Toxicol. 2012 Apr; 8(4):467-85. Zuniga FI, Loi D, Ling KH, Tang-Liu DD. PMID: 22394356.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    4. Aqueous humor penetration of topical bimatoprost 0.01% and bimatoprost 0.03% in rabbits: response to authors. Clin Ophthalmol. 2011; 5:1119-20. Chang-Lin JE, Batoosingh AL, Hollander DA, Schiffman RM, Tang-Liu DD. PMID: 21887092.
      View in: PubMed   Mentions:
    5. Predictable prolonged suppression of gastric acidity with a novel proton pump inhibitor, AGN 201904-Z. Aliment Pharmacol Ther. 2008 Jul; 28(2):187-99. Hunt RH, Armstrong D, Yaghoobi M, James C, Chen Y, Leonard J, Shin JM, Lee E, Tang-Liu D, Sachs G. PMID: 18445141.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    6. Cytochrome P450 3A expression and activity in the rabbit lacrimal gland: glucocorticoid modulation and the impact on androgen metabolism. Invest Ophthalmol Vis Sci. 2005 Dec; 46(12):4697-706. Attar M, Ling KH, Tang-Liu DD, Neamati N, Lee VH. PMID: 16303967.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Disposition and biotransformation of the acetylenic retinoid tazarotene in humans. J Pharm Sci. 2005 Oct; 94(10):2246-55. Attar M, Yu D, Ni J, Yu Z, Ling KH, Tang-Liu DD. PMID: 16136553.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    8. Enzymatic formation of prostamide F2alpha from anandamide involves a newly identified intermediate metabolite, prostamide H2. J Lipid Res. 2005 Dec; 46(12):2745-51. Yang W, Ni J, Woodward DF, Tang-Liu DD, Ling KH. PMID: 16150817.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    9. Ophthalmic drug delivery considerations at the cellular level: drug-metabolising enzymes and transporters. Expert Opin Drug Deliv. 2005 Sep; 2(5):891-908. Attar M, Shen J, Ling KH, Tang-Liu D. PMID: 16296785.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    10. Ocular pharmacokinetics and safety of ciclosporin, a novel topical treatment for dry eye. Clin Pharmacokinet. 2005; 44(3):247-61. Tang-Liu DD, Acheampong A. PMID: 15762768.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    11. Effects of the preservative purite on the bioavailability of brimonidine in the aqueous humor of rabbits. J Ocul Pharmacol Ther. 2004 Aug; 20(4):285-92. Dong JQ, Babusis DM, Welty DF, Acheampong AA, Tang-Liu D, Whitcup SM. PMID: 15321023.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    12. Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry. J Lipid Res. 2004 Apr; 45(4):757-63. Weber A, Ni J, Ling KH, Acheampong A, Tang-Liu DD, Burk R, Cravatt BF, Woodward D. PMID: 14729864.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    13. Tazarotene does not affect the pharmacokinetics and efficacy of a norethindrone/ethinylestradiol oral contraceptive. Clin Pharmacokinet. 2004; 43(10):673-84. Yu Z, Yu D, Walker PS, Tang-Liu DD. PMID: 15244497.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    14. Intramuscular injection of 125I-botulinum neurotoxin-complex versus 125I-botulinum-free neurotoxin: time course of tissue distribution. Toxicon. 2003 Oct; 42(5):461-9. Tang-Liu DD, Aoki KR, Dolly JO, de Paiva A, Houchen TL, Chasseaud LF, Webber C. PMID: 14529727.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    15. A phase 1 study of tazarotene in adults with advanced cancer. Br J Cancer. 2003 Sep 01; 89(5):808-15. Jones PH, Burnett RD, Fainaru I, Nadolny P, Walker P, Yu Z, Tang-Liu D, Ganesan TS, Talbot DC, Harris AL, Rustin GJ. PMID: 12942109.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    16. Evaluation of an immortalized retinal endothelial cell line as an in vitro model for drug transport studies across the blood-retinal barrier. Pharm Res. 2003 Sep; 20(9):1357-63. Shen J, Cross ST, Tang-Liu DD, Welty DF. PMID: 14567628.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    17. Cytochrome P450 2C8 and flavin-containing monooxygenases are involved in the metabolism of tazarotenic acid in humans. Drug Metab Dispos. 2003 Apr; 31(4):476-81. Attar M, Dong D, Ling KH, Tang-Liu DD. PMID: 12642475.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    18. Pharmacological characterization of a novel antiglaucoma agent, Bimatoprost (AGN 192024). J Pharmacol Exp Ther. 2003 May; 305(2):772-85. Woodward DF, Krauss AH, Chen J, Liang Y, Li C, Protzman CE, Bogardus A, Chen R, Kedzie KM, Krauss HA, Gil DW, Kharlamb A, Wheeler LA, Babusis D, Welty D, Tang-Liu DD, Cherukury M, Andrews SW, Burk RM, Garst ME. PMID: 12606640.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    19. Pharmacokinetics of tazarotene cream 0.1% after a single dose and after repeat topical applications at clinical or exaggerated application rates in patients with acne vulgaris or photodamaged skin. Clin Pharmacokinet. 2003; 42(10):921-9. Yu Z, Sefton J, Lew-Kaya D, Walker P, Yu D, Tang-Liu DD. PMID: 12885265.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    20. Blood concentrations of cyclosporin a during long-term treatment with cyclosporin a ophthalmic emulsions in patients with moderate to severe dry eye disease. J Ocul Pharmacol Ther. 2002 Oct; 18(5):411-8. Small DS, Acheampong A, Reis B, Stern K, Stewart W, Berdy G, Epstein R, Foerster R, Forstot L, Tang-Liu DD. PMID: 12419092.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    21. Formulation effects on ocular absorption of brimonidine in rabbit eyes. J Ocul Pharmacol Ther. 2002 Aug; 18(4):325-37. Acheampong AA, Small D, Baumgarten V, Welty D, Tang-Liu D. PMID: 12222763.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    22. Distribution of brimonidine into anterior and posterior tissues of monkey, rabbit, and rat eyes. Drug Metab Dispos. 2002 Apr; 30(4):421-9. Acheampong AA, Shackleton M, John B, Burke J, Wheeler L, Tang-Liu D. PMID: 11901096.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    23. The pharmacology of bimatoprost (Lumigan). Surv Ophthalmol. 2001 May; 45 Suppl 4:S337-45. Woodward DF, Krauss AH, Chen J, Lai RK, Spada CS, Burk RM, Andrews SW, Shi L, Liang Y, Kedzie KM, Chen R, Gil DW, Kharlamb A, Archeampong A, Ling J, Madhu C, Ni J, Rix P, Usansky J, Usansky H, Weber A, Welty D, Yang W, Tang-Liu DD, Garst ME, Brar B, Wheeler LA, Kaplan LJ. PMID: 11434936.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    24. Ophthalmic drops causing coma in an infant. J Pediatr. 2001 Mar; 138(3):441-3. Berlin RJ, Lee UT, Samples JR, Rich LF, Tang-Liu DD, Sing KA, Steiner RD. PMID: 11241061.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    25. Comparison of tear sampling techniques for pharmacokinetics analysis: ofloxacin concentrations in rabbit tears after sampling with schirmer tear strips, capillary tubes, or surgical sponges. J Ocul Pharmacol Ther. 2000 Oct; 16(5):439-46. Small D, Hevy J, Tang-Liu D. PMID: 11110035.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    26. Clinical pharmacokinetics and drug metabolism of tazarotene: a novel topical treatment for acne and psoriasis. Clin Pharmacokinet. 1999 Oct; 37(4):273-87. Tang-Liu DD, Matsumoto RM, Usansky JI. PMID: 10554045.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    27. Distribution of cyclosporin A in ocular tissues after topical administration to albino rabbits and beagle dogs. Curr Eye Res. 1999 Feb; 18(2):91-103. Acheampong AA, Shackleton M, Tang-Liu DD, Ding S, Stern ME, Decker R. PMID: 10223652.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    28. Penetration of natural prostaglandins and their ester prodrugs and analogs across human ocular tissues in vitro. J Ocul Pharmacol Ther. 1998 Oct; 14(5):389-99. Madhu C, Rix P, Nguyen T, Chien DS, Woodward DF, Tang-Liu DD. PMID: 9811228.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. Cyclosporine distribution into the conjunctiva, cornea, lacrimal gland, and systemic blood following topical dosing of cyclosporine to rabbit, dog, and human eyes. Adv Exp Med Biol. 1998; 438:1001-4. Acheampong A, Shackleton M, Lam S, Rudewicz P, Tang-Liu D. PMID: 9635002.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    30. Ocular penetration and bioconversion of prostaglandin F2alpha prodrugs in rabbit cornea and conjunctiva. J Pharm Sci. 1997 Oct; 86(10):1180-6. Chien DS, Tang-Liu DD, Woodward DF. PMID: 9344177.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    31. The use of precision-cut rat lung slices for studying PGF(2a) metabolism. Environ Toxicol Pharmacol. 1997 Sep; 3(4):251-6. Madhu C, Rix P, Small D, Yuan YD, Tang-Liu DD. PMID: 21781785.
      View in: PubMed   Mentions:    Fields:    
    32. Metabolic deesterification of tazarotene in human blood and rat and human liver microsomes. J Pharm Sci. 1997 Aug; 86(8):972-4. Madhu C, Duff S, Baumgarten V, Rix P, Small D, Tang-Liu D. PMID: 9269878.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    33. Characterization of brimonidine metabolism with rat, rabbit, dog, monkey and human liver fractions and rabbit liver aldehyde oxidase. Xenobiotica. 1996 Oct; 26(10):1035-55. Acheampong AA, Chien DS, Lam S, Vekich S, Breau A, Usansky J, Harcourt D, Munk SA, Nguyen H, Garst M, Tang-Liu D. PMID: 8905918.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    34. Effect of benzalkonium chloride/EDTA on the ocular bioavailability of ketorolac tromethamine following ocular instillation to normal and de-epithelialized corneas of rabbits. J Pharm Sci. 1996 Apr; 85(4):415-8. Madhu C, Rix PJ, Shackleton MJ, Nguyen TG, Tang-Liu DD. PMID: 8901080.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    35. Preclinical safety profile of brimonidine. Eur J Ophthalmol. 1996 Jan-Mar; 6(1):21-5. Angelov OV, Wiese AG, Tang-Liu DD, Acheampong AA, Ismail IM, Brar BS. PMID: 8744846.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    36. Measurement of brimonidine concentrations in human plasma by a highly sensitive gas chromatography/mass spectrometric assay. J Pharm Biomed Anal. 1995 Jul; 13(8):995-1002. Acheampong A, Tang-Liu DD. PMID: 8580159.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    37. Comparative ocular pharmacokinetics of brimonidine after a single dose application to the eyes of albino and pigmented rabbits. Drug Metab Dispos. 1995 Jul; 23(7):708-12. Acheampong AA, Shackleton M, Tang-Liu DD. PMID: 7587958.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    38. Comparison of concentration-time profiles of levobunolol and timolol in anterior and posterior ocular tissues of albino rabbits. J Ocul Pharmacol Ther. 1995; 11(4):489-502. Acheampong AA, Breau A, Shackleton M, Luo W, Lam S, Tang-Liu DD. PMID: 8574812.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    39. Availability of 0.3% ofloxacin ointment and solution in human conjunctiva and aqueous humor. J Ocul Pharmacol Ther. 1995; 11(1):57-63. Tang-Liu D, Lambert J, Blancaflor S, Gwon A. PMID: 8535958.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCTClinical Trials
    40. Pharmacokinetics of a novel retinoid AGN 190168 and its metabolite AGN 190299 after intravenous administration of AGN 190168 to rats. Biopharm Drug Dispos. 1994 Jul; 15(5):347-57. Hsyu PH, Bowen B, Tang-Liu D. PMID: 7981424.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    41. Comparative tear concentrations over time of ofloxacin and tobramycin in human eyes. Clin Pharmacol Ther. 1994 Mar; 55(3):284-92. Tang-Liu DD, Schwob DL, Usansky JI, Gordon YJ. PMID: 8143394.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    42. The effect of pilocarpine on ocular levobunolol absorption from ophthalmic solutions. J Ocul Pharmacol. 1994; 10(4):605-15. Tang-Liu DD, Richman JB. PMID: 7714404.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    43. Effects of four penetration enhancers on corneal permeability of drugs in vitro. J Pharm Sci. 1994 Jan; 83(1):85-90. Tang-Liu DD, Richman JB, Weinkam RJ, Takruri H. PMID: 8138917.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    44. Disposition of SK&F L-190144 in rats and monkeys after oral, intravenous or ocular administration. Biopharm Drug Dispos. 1993 May; 14(4):313-24. Tang-Liu DD, Richman JB, Lin P, Selim S. PMID: 8499582.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    45. Comparison of azone and hexamethylene lauramide in toxicologic effects and penetration enhancement of cimetidine in rabbit eyes. Pharm Res. 1992 Jun; 9(6):817-21. Ismail IM, Chen CC, Richman JB, Andersen JS, Tang-Liu DD. PMID: 1409367.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    46. Ofloxacin in human serum, urine, and tear film after topical application. Cornea. 1992 May; 11(3):226-30. Borrmann L, Tang-Liu DD, Kann J, Nista J, Lin ET, Frank J. PMID: 1587130.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    47. Topical ofloxacin in the treatment of Pseudomonas keratitis in a rabbit model. Cornea. 1992 Mar; 11(2):143-7. Gritz DC, McDonnell PJ, Lee TY, Tang-Liu D, Hubbard BB, Gwon A. PMID: 1582217.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    48. Precorneal sampling techniques for ophthalmic gels. J Ocul Pharmacol. 1992; 8(2):151-9. Ding S, Chen CC, Salome-Kesslak R, Tang-Liu DD, Himmelstein KJ. PMID: 1506756.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    49. Lenticular uptake and distribution of xenobiotics and amino acids. J Ocul Pharmacol. 1992; 8(3):267-77. Tang-Liu DD, Richman JB, Liu SS. PMID: 1453088.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    50. Corneal and conjunctival/scleral penetration of p-aminoclonidine, AGN 190342, and clonidine in rabbit eyes. Curr Eye Res. 1990 Nov; 9(11):1051-9. Chien DS, Homsy JJ, Gluchowski C, Tang-Liu DD. PMID: 1982760.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    51. Systemic pharmacokinetics of acetylenic retinoids in rats. Drug Metab Dispos. 1990 Nov-Dec; 18(6):1071-7. Liu SS, Sandri R, Tang-Liu DD. PMID: 1981515.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    52. Comparison of ofloxacin, gentamicin, and tobramycin concentrations in tears and in vitro MICs for 90% of test organisms. Antimicrob Agents Chemother. 1990 Aug; 34(8):1602-4. Richman J, Zolezio H, Tang-Liu D. PMID: 2221871.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    53. A corneal perfusion device for estimating ocular bioavailability in vitro. J Pharm Sci. 1990 Feb; 79(2):153-7. Richman JB, Tang-Liu DD. PMID: 2324964.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    54. Ocular biodistribution of clonidine after topical application with ophthalmic rods or solution. J Ocul Pharmacol. 1989; 5(2):133-40. Tang-Liu DD, Sandri R. PMID: 2754298.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    55. Percutaneous and systemic disposition of hexamethylene lauramide and its penetration enhancement effect on hydrocortisone in a rat sandwich skin-flap model. Pharm Res. 1988 Aug; 5(8):477-81. Tang-Liu DD, Neff J, Zolezio H, Sandri R. PMID: 3244654.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    56. The effect of azone on ocular levobunolol absorption: calculating the area under the curve and its standard error using tissue sampling compartments. Pharm Res. 1988 Apr; 5(4):238-41. Tang-Liu DD, Burke PJ. PMID: 3073384.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    57. Ocular metabolism of levobunolol. J Ocul Pharmacol. 1988; 4(3):269-78. Tang-Liu DD, Shackleton M, Richman JB. PMID: 3058836.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    58. Disposition of levobunolol after an ophthalmic dose to rabbits. J Pharm Sci. 1987 Oct; 76(10):780-3. Tang-Liu DD, Liu S, Neff J, Sandri R. PMID: 3323465.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    59. Relationship between the ocular and systemic disposition of flurbiprofen: the effect of altered protein dynamics at steady state. J Pharmacokinet Biopharm. 1987 Aug; 15(4):387-97. Tang-Liu DD, Liu S. PMID: 3681666.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    60. Plasma levobunolol levels following topical administration with reference to systemic side effects. Ophthalmologica. 1987; 194(4):194-200. Novack GD, Tang-Liu DD, Kelley EP, Liu SS, Shen CD, Duzman E. PMID: 3306546.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    61. Comparison of the urinary metabolite profile of caffeine in young and elderly males. Br J Clin Pharmacol. 1985 Feb; 19(2):225-32. Blanchard J, Sawers SJ, Jonkman JH, Tang-Liu DD. PMID: 3986081.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    62. Ocular and systemic bioavailability of ophthalmic flurbiprofen. J Pharmacokinet Biopharm. 1984 Dec; 12(6):611-26. Tang-Liu DD, Liu SS, Weinkam RJ. PMID: 6533296.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    63. Dependence of renal clearance on urine flow: a mathematical model and its application. J Pharm Sci. 1983 Feb; 72(2):154-8. Tang-Liu DD, Tozer TN, Riegelman S. PMID: 6834253.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    64. Disposition of caffeine and its metabolites in man. J Pharmacol Exp Ther. 1983 Jan; 224(1):180-5. Tang-Liu DD, Williams RL, Riegelman S. PMID: 6848742.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    65. Urine flow-dependence of theophylline renal clearance in man. J Pharmacokinet Biopharm. 1982 Aug; 10(4):351-64. Tang-Liu DD, Tozer TN, Riegelman S. PMID: 7153869.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    66. An automated HPLC assay for simultaneous quantitation of methylated xanthines and uric acids in urine. J Chromatogr Sci. 1982 Apr; 20(4):155-9. Tang-Liu DD, Riegelman S. PMID: 7096523.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    67. Nonlinear theophylline elimination. Clin Pharmacol Ther. 1982 Mar; 31(3):358-69. Tang-Liu DD, Williams RL, Riegelman S. PMID: 7060318.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    68. Metabolism of theophylline to caffeine in adults. Res Commun Chem Pathol Pharmacol. 1981 Dec; 34(3):371-80. Tang-Liu DD, Riegelman S. PMID: 7323439.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
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