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Donald McDonald, MD, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentAnatomy
Address513 Parnassus Ave, Med Sci
San Francisco CA 94143
Phone415-476-6616
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.1974 Graduate Division (Endocrinology)
    University of California, San FranciscoM.D.1965 Medicine

    Collapse Overview 
    Collapse Overview
    Research in my laboratory is examining the cellular mechanisms of angiogenesis, vascular remodeling, and lymphangiogenesis in mouse models of cancer, chronic inflammation, and obesity. We use in-vivo cell-biological approaches to determine how abnormalities of blood vessels and lymphatics contribute to disease pathophysiology. Current interests include developing approaches for preventing, stopping, or reversing disease-related changes in blood vessels and lymphatics and learning the consequences of these actions. Related interests include the regulation of endothelial barrier function, downstream effects of altered plasma leakage and cellular trafficking, and control mechanisms of tissue fluid and cell clearance by lymphatics.

    Projects in the laboratory use mouse models to dissect the role of key growth factors and receptors involved in growth and remodeling of blood vessels and lymphatics and related disease processes. VEGF-A, VEGF-C, angiopoietins, TNF-alpha, HGF and their receptors are of current interest. Signaling is manipulated in vivo by switchable transgenic overexpression, genetic deletion, viral vectors, or pharmacological agonists or inhibitors. Ongoing studies are using the models to examine factors that drive or modify remodeling of blood vessels and lymphatics in inflammatory conditions, with an emphasis on the airways, lungs, and adipose tissue. We are also studying favorable and potentially unfavorable effects of destroying blood vessels and/or lymphatics in tumors, reflected by tumor growth, invasion, and metastasis. The overall goal is to advance the understanding and development of strategies that can stop or reverse angiogenesis and lymphangiogenesis and to characterize the downstream benefits and consequences in cancer, inflammatory disease, and obesity.


    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms, consequences, and reversal of abnormalities in lung lymphatics
    NIH/NHLBI R01HL127402Apr 1, 2015 - Feb 28, 2019
    Role: Principal Investigator
    Lymphangiogenesis and Angiogenesis in Airway Inflammation
    NIH/NHLBI R01HL096511Aug 1, 2009 - May 10, 2010
    Role: Principal Investigator
    Angiopoietins in vascular and lymphatic remodeling of airways and lung
    NIH/NHLBI R01HL059157Apr 5, 1998 - May 31, 2016
    Role: Principal Investigator
    Development and Control of Pulmonary alveolar Stability
    NIH P01HL024075Jul 1, 1979 - Dec 31, 2015
    Role: Co-Investigator
    Evolving Microenvironments in Airway Inflammation
    NIH/NHLBI P01HL024136Jul 1, 1979 - Mar 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kim M, Nitschké M, Sennino B, Murer P, Schriver BJ, Bell A, Subramanian A, McDonald CE, Wang J, Cha H, Bourgeois-Daigneault MC, Kirn DH, Bell JC, De Silva N, Breitbach CJ, McDonald D. Amplification of Oncolytic Vaccinia Virus Widespread Tumor Cell Killing by Sunitinib through Multiple Mechanisms. Cancer Res. 2018 Feb 15; 78(4):922-937. PMID: 29259007.
      View in: PubMed
    2. Shepherd J, Fisher M, Welford A, McDonald D, Kanthou C, Tozer GM. The protective role of sphingosine-1-phosphate against the action of the vascular disrupting agent combretastatin A-4 3-O-phosphate. Oncotarget. 2017 Nov 10; 8(56):95648-95661. PMID: 29221156.
      View in: PubMed
    3. Baluk P, Yao LC, Flores JC, Choi D, Hong YK, McDonald D. Rapamycin reversal of VEGF-C-driven lymphatic anomalies in the respiratory tract. JCI Insight. 2017 Aug 17; 2(16). PMID: 28814666.
      View in: PubMed
    4. Nitschké M, Bell A, Karaman S, Amouzgar M, Rutkowski JM, Scherer PE, Alitalo K, McDonald D. Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations. Am J Pathol. 2017 Sep; 187(9):1984-1997. PMID: 28683257.
      View in: PubMed
    5. Kim M, Allen B, Korhonen EA, Nitschké M, Yang HW, Baluk P, Saharinen P, Alitalo K, Daly C, Thurston G, McDonald D. Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation. J Clin Invest. 2016 Sep 01; 126(9):3511-25. PMID: 27548529; PMCID: PMC5004955 [Available on 12/01/16].
    6. Korhonen EA, Lampinen A, Giri H, Anisimov A, Kim M, Allen B, Fang S, D'Amico G, Sipilä TJ, Lohela M, Strandin T, Vaheri A, Ylä-Herttuala S, Koh GY, McDonald D, Alitalo K, Saharinen P. Tie1 controls angiopoietin function in vascular remodeling and inflammation. J Clin Invest. 2016 Sep 01; 126(9):3495-510. PMID: 27548530; PMCID: PMC5004934 [Available on 12/01/16].
    7. Moen I, Gebre M, Alonso-Camino V, Chen D, Epstein D, McDonald D. Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumors. Clin Exp Metastasis. 2015 Dec; 32(8):799-817. PMID: 26445848; PMCID: PMC4651821 [Available on 12/01/16].
    8. Le CT, Laidlaw G, Morehouse CA, Naiman B, Brohawn P, Mustelin T, Connor JR, McDonald D. Synergistic actions of blocking angiopoietin-2 and tumor necrosis factor-a in suppressing remodeling of blood vessels and lymphatics in airway inflammation. Am J Pathol. 2015 Nov; 185(11):2949-68. PMID: 26348576; PMCID: PMC4630170 [Available on 11/01/16].
    9. Huang JL, Woolf AS, Kolatsi-Joannou M, Baluk P, Sandford RN, Peters DJ, McDonald D, Price KL, Winyard PJ, Long DA. Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases. J Am Soc Nephrol. 2016 Jan; 27(1):69-77. PMID: 26038530; PMCID: PMC4696565 [Available on 01/01/17].
    10. Raymond WW, Xu X, Nimishakavi S, Le C, McDonald D, Caughey GH. Regulation of hepatocyte growth factor in mice with pneumonia by peptidases and trans-alveolar flux. PLoS One. 2015; 10(5):e0125797. PMID: 25938594; PMCID: PMC4418689.
    11. Bose O, Baluk P, Looney MR, Cheng LE, McDonald D, Caughey GH, Krummel MF. Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice. PLoS One. 2015; 10(3):e0118513. PMID: 25789765; PMCID: PMC4366375.
    12. Baluk P, Phillips K, Yao LC, Adams A, Nitschké M, McDonald D. Neutrophil dependence of vascular remodeling after Mycoplasma infection of mouse airways. Am J Pathol. 2014 Jun; 184(6):1877-89. PMID: 24726646; PMCID: PMC4044721.
    13. Baluk P, Adams A, Phillips K, Feng J, Hong YK, Brown MB, McDonald D. Preferential lymphatic growth in bronchus-associated lymphoid tissue in sustained lung inflammation. Am J Pathol. 2014 May; 184(5):1577-92. PMID: 24631179; PMCID: PMC4005985.
    14. Yao LC, Testini C, Tvorogov D, Anisimov A, Vargas SO, Baluk P, Pytowski B, Claesson-Welsh L, Alitalo K, McDonald D. Pulmonary lymphangiectasia resulting from vascular endothelial growth factor-C overexpression during a critical period. Circ Res. 2014 Feb 28; 114(5):806-22. PMID: 24429550; PMCID: PMC3969887.
    15. Yao LC, McDonald D. Plasticity of airway lymphatics in development and disease. Adv Anat Embryol Cell Biol. 2014; 214:41-54. PMID: 24276885; PMCID: PMC3955364.
    16. Xu X, Greenland J, Baluk P, Adams A, Bose O, McDonald D, Caughey GH. Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis. Am J Respir Cell Mol Biol. 2013 Sep; 49(3):437-44. PMID: 23600672; PMCID: PMC3824055.
    17. Khurana A, Chapelin F, Beck G, Lenkov OD, Donig J, Nejadnik H, Messing S, Derugin N, Chan RC, Gaur A, Sennino B, McDonald D, Kempen PJ, Tikhomirov GA, Rao J, Daldrup-Link HE. Iron administration before stem cell harvest enables MR imaging tracking after transplantation. Radiology. 2013 Oct; 269(1):186-97. PMID: 23850832; PMCID: PMC3781357.
    18. Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald D, McCune JM. IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia. Int Immunol. 2013 Aug; 25(8):471-83. PMID: 23657000; PMCID: PMC3720065.
    19. Sennino B, Ishiguro-Oonuma T, Schriver BJ, Christensen JG, McDonald D. Inhibition of c-Met reduces lymphatic metastasis in RIP-Tag2 transgenic mice. Cancer Res. 2013 Jun 15; 73(12):3692-703. PMID: 23576559; PMCID: PMC3686901.
    20. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald D, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. PMID: 23607856.
      View in: PubMed
    21. Baluk P, Hogmalm A, Bry M, Alitalo K, Bry K, McDonald D. Transgenic overexpression of interleukin-1ß induces persistent lymphangiogenesis but not angiogenesis in mouse airways. Am J Pathol. 2013 Apr; 182(4):1434-47. PMID: 23391392; PMCID: PMC3620402.
    22. Nejadnik H, Henning TD, Do T, Sutton EJ, Baehner F, Horvai A, Sennino B, McDonald D, Meier R, Misselwitz B, Link TM, Daldrup-Link HE. MR imaging features of gadofluorine-labeled matrix-associated stem cell implants in cartilage defects. PLoS One. 2012; 7(12):e49971. PMID: 23251354; PMCID: PMC3520977.
    23. Sennino B, McDonald D. Controlling escape from angiogenesis inhibitors. Nat Rev Cancer. 2012 10; 12(10):699-709. PMID: 23001349; PMCID: PMC3969886.
    24. Henning TD, Gawande R, Khurana A, Tavri S, Mandrussow L, Golovko D, Horvai A, Sennino B, McDonald D, Meier R, Wendland M, Derugin N, Link TM, Daldrup-Link HE. Magnetic resonance imaging of ferumoxide-labeled mesenchymal stem cells in cartilage defects: in vitro and in vivo investigations. Mol Imaging. 2012 Jun; 11(3):197-209. PMID: 22554484; PMCID: PMC3727234.
    25. Yao LC, Baluk P, Srinivasan RS, Oliver G, McDonald D. Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation. Am J Pathol. 2012 Jun; 180(6):2561-75. PMID: 22538088; PMCID: PMC3378913.
    26. Banfi A, von Degenfeld G, Gianni-Barrera R, Reginato S, Merchant MJ, McDonald D, Blau HM. Therapeutic angiogenesis due to balanced single-vector delivery of VEGF and PDGF-BB. FASEB J. 2012 Jun; 26(6):2486-97. PMID: 22391130; PMCID: PMC3360154.
    27. Sennino B, Ishiguro-Oonuma T, Wei Y, Naylor RM, Williamson CW, Bhagwandin V, Tabruyn SP, You WK, Chapman HA, Christensen JG, Aftab DT, McDonald D. Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors. Cancer Discov. 2012 Mar; 2(3):270-87. PMID: 22585997; PMCID: PMC3354652.
    28. Orsenigo F, Giampietro C, Ferrari A, Corada M, Galaup A, Sigismund S, Ristagno G, Maddaluno L, Koh GY, Franco D, Kurtcuoglu V, Poulikakos D, Baluk P, McDonald D, Grazia Lampugnani M, Dejana E. Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo. Nat Commun. 2012; 3:1208. PMID: 23169049; PMCID: PMC3514492.
    29. McDonald D, Yao LC, Baluk P. Dynamics of airway blood vessels and lymphatics: lessons from development and inflammation. Proc Am Thorac Soc. 2011 Nov; 8(6):504-7. PMID: 22052927; PMCID: PMC3359074.
    30. Cyran CC, Sennino B, Fu Y, Rogut V, Shames DM, Chaopathomkul B, Wendland MF, McDonald D, Brasch RC, Raatschen HJ. Permeability to macromolecular contrast media quantified by dynamic MRI correlates with tumor tissue assays of vascular endothelial growth factor (VEGF). Eur J Radiol. 2012 May; 81(5):891-6. PMID: 21889860; PMCID: PMC3242157.
    31. Lopez JI, Kang I, You WK, McDonald D, Weaver VM. In situ force mapping of mammary gland transformation. Integr Biol (Camb). 2011 Sep; 3(9):910-21. PMID: 21842067; PMCID: PMC3564969.
    32. Falcon BL, Pietras K, Chou J, Chen D, Sennino B, Hanahan D, McDonald D. Increased vascular delivery and efficacy of chemotherapy after inhibition of platelet-derived growth factor-B. Am J Pathol. 2011 Jun; 178(6):2920-30. PMID: 21641409; PMCID: PMC3124291.
    33. You WK, Sennino B, Williamson CW, Falcón B, Hashizume H, Yao LC, Aftab DT, McDonald D. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res. 2011 Jul 15; 71(14):4758-68. PMID: 21613405; PMCID: PMC3138890.
    34. Fuxe J, Tabruyn S, Colton K, Zaid H, Adams A, Baluk P, Lashnits E, Morisada T, Le T, O'Brien S, Epstein DM, Koh GY, McDonald D. Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation. Am J Pathol. 2011 Jun; 178(6):2897-909. PMID: 21550017; PMCID: PMC3124300.
    35. Witte MH, Dellinger MT, McDonald D, Nathanson SD, Boccardo FM, Campisi CC, Sleeman JP, Gershenwald JE. Lymphangiogenesis and hemangiogenesis: potential targets for therapy. J Surg Oncol. 2011 May 01; 103(6):489-500. PMID: 21480241; PMCID: PMC4422163.
    36. Falcon BL, Barr S, Gokhale PC, Chou J, Fogarty J, Depeille P, Miglarese M, Epstein DM, McDonald D. Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors. Cancer Res. 2011 Mar 01; 71(5):1573-83. PMID: 21363918; PMCID: PMC3077087.
    37. McDonald D. New antibody to stop tumor angiogenesis and lymphatic spread by blocking receptor partnering. Cancer Cell. 2010 Dec 14; 18(6):541-3. PMID: 21156277; PMCID: PMC3031147.
    38. Tabruyn SP, Colton K, Morisada T, Fuxe J, Wiegand SJ, Thurston G, Coyle AJ, Connor J, McDonald D. Angiopoietin-2-driven vascular remodeling in airway inflammation. Am J Pathol. 2010 Dec; 177(6):3233-43. PMID: 20952594; PMCID: PMC2993300.
    39. Coxon A, Bready J, Min H, Kaufman S, Leal J, Yu D, Lee TA, Sun JR, Estrada J, Bolon B, McCabe J, Wang L, Rex K, Caenepeel S, Hughes P, Cordover D, Kim H, Han SJ, Michaels ML, Hsu E, Shimamoto G, Cattley R, Hurh E, Nguyen L, Wang SX, Ndifor A, Hayward IJ, Falcón BL, McDonald D, Li L, Boone T, Kendall R, Radinsky R, Oliner JD. Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody. Mol Cancer Ther. 2010 Oct; 9(10):2641-51. PMID: 20937592; PMCID: PMC4430860.
    40. Nedopil A, Klenk C, Kim C, Liu S, Wendland M, Golovko D, Schuster T, Sennino B, McDonald D, Daldrup-Link HE. MR signal characteristics of viable and apoptotic human mesenchymal stem cells in matrix-associated stem cell implants for treatment of osteoarthritis. Invest Radiol. 2010 Oct; 45(10):634-40. PMID: 20808236; PMCID: PMC2943569.
    41. Erzurum S, Rounds SI, Stevens T, Aldred M, Aliotta J, Archer SL, Asosingh K, Balaban R, Bauer N, Bhattacharya J, Bogaard H, Choudhary G, Dorn GW, Dweik R, Fagan K, Fallon M, Finkel T, Geraci M, Gladwin MT, Hassoun PM, Humbert M, Kaminski N, Kawut SM, Loscalzo J, McDonald D, McMurtry IF, Newman J, Nicolls M, Rabinovitch M, Shizuru J, Oka M, Polgar P, Rodman D, Schumacker P, Stenmark K, Tuder R, Voelkel N, Sullivan E, Weinshilboum R, Yoder MC, Zhao Y, Gail D, Moore TM. Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report. Am J Respir Crit Care Med. 2010 Dec 15; 182(12):1554-62. PMID: 20833821.
      View in: PubMed
    42. Ni A, Lashnits E, Yao LC, Baluk P, McDonald D. Rapid remodeling of airway vascular architecture at birth. Dev Dyn. 2010 Sep; 239(9):2354-66. PMID: 20730909; PMCID: PMC2997630.
    43. Mounzer RH, Svendsen OS, Baluk P, Bergman CM, Padera TP, Wiig H, Jain RK, McDonald D, Ruddle NH. Lymphotoxin-alpha contributes to lymphangiogenesis. Blood. 2010 Sep 23; 116(12):2173-82. PMID: 20566898; PMCID: PMC2951858.
    44. Hashizume H, Falcón BL, Kuroda T, Baluk P, Coxon A, Yu D, Bready JV, Oliner JD, McDonald D. Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth. Cancer Res. 2010 Mar 15; 70(6):2213-23. PMID: 20197469; PMCID: PMC2840050.
    45. You WK, Kasman I, Hu-Lowe DD, McDonald D. Ricinus communis agglutinin I leads to rapid down-regulation of VEGFR-2 and endothelial cell apoptosis in tumor blood vessels. Am J Pathol. 2010 Apr; 176(4):1927-40. PMID: 20185574; PMCID: PMC2843481.
    46. Fuxe J, Lashnits E, O'Brien S, Baluk P, Tabruyn SP, Kuhnert F, Kuo C, Thurston G, McDonald D. Angiopoietin/Tie2 signaling transforms capillaries into venules primed for leukocyte trafficking in airway inflammation. Am J Pathol. 2010 Apr; 176(4):2009-18. PMID: 20133818; PMCID: PMC2843488.
    47. Yao LC, Baluk P, Feng J, McDonald D. Steroid-resistant lymphatic remodeling in chronically inflamed mouse airways. Am J Pathol. 2010 Mar; 176(3):1525-41. PMID: 20093490; PMCID: PMC2832171.
    48. Pham TH, Baluk P, Xu Y, Grigorova I, Bankovich AJ, Pappu R, Coughlin SR, McDonald D, Schwab SR, Cyster JG. Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med. 2010 Jan 18; 207(1):17-27. PMID: 20026661; PMCID: PMC2812554.
    49. Falcón BL, Hashizume H, Koumoutsakos P, Chou J, Bready JV, Coxon A, Oliner JD, McDonald D. Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels. Am J Pathol. 2009 Nov; 175(5):2159-70. PMID: 19815705; PMCID: PMC2774078.
    50. Baluk P, Yao LC, Feng J, Romano T, Jung SS, Schreiter JL, Yan L, Shealy DJ, McDonald D. TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice. J Clin Invest. 2009 Oct; 119(10):2954-64. PMID: 19759514; PMCID: PMC2752063.
    51. Sennino B, Raatschen HJ, Wendland MF, Fu Y, You WK, Shames DM, McDonald D, Brasch RC. Correlative dynamic contrast MRI and microscopic assessments of tumor vascularity in RIP-Tag2 transgenic mice. Magn Reson Med. 2009 Sep; 62(3):616-25. PMID: 19526501.
      View in: PubMed
    52. Henning TD, Wendland MF, Golovko D, Sutton EJ, Sennino B, Malek F, Bauer JS, McDonald D, Daldrup-Link H. Relaxation effects of ferucarbotran-labeled mesenchymal stem cells at 1.5T and 3T: discrimination of viable from lysed cells. Magn Reson Med. 2009 Aug; 62(2):325-32. PMID: 19353670; PMCID: PMC2931823.
    53. Henning TD, Sutton EJ, Kim A, Golovko D, Horvai A, Ackerman L, Sennino B, McDonald D, Lotz J, Daldrup-Link HE. The influence of ferucarbotran on the chondrogenesis of human mesenchymal stem cells. Contrast Media Mol Imaging. 2009 Jul-Aug; 4(4):165-73. PMID: 19670250; PMCID: PMC2933782.
    54. Okazaki T, Ni A, Baluk P, Ayeni OA, Kearley J, Coyle AJ, Humbles A, McDonald D. Capillary defects and exaggerated inflammatory response in the airways of EphA2-deficient mice. Am J Pathol. 2009 Jun; 174(6):2388-99. PMID: 19443703; PMCID: PMC2684202.
    55. Okazaki T, Ni A, Ayeni OA, Baluk P, Yao LC, Vossmeyer D, Zischinsky G, Zahn G, Knolle J, Christner C, McDonald D. alpha5beta1 Integrin blockade inhibits lymphangiogenesis in airway inflammation. Am J Pathol. 2009 Jun; 174(6):2378-87. PMID: 19443705; PMCID: PMC2684201.
    56. Sennino B, Kuhnert F, Tabruyn SP, Mancuso MR, Hu-Lowe DD, Kuo CJ, McDonald D. Cellular source and amount of vascular endothelial growth factor and platelet-derived growth factor in tumors determine response to angiogenesis inhibitors. Cancer Res. 2009 May 15; 69(10):4527-36. PMID: 19401451; PMCID: PMC2759816.
    57. You WK, McDonald D. The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis. BMB Rep. 2008 Dec 31; 41(12):833-9. PMID: 19123972; PMCID: PMC4417610.
    58. Johnson NC, Dillard ME, Baluk P, McDonald D, Harvey NL, Frase SL, Oliver G. Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity. Genes Dev. 2008 Dec 01; 22(23):3282-91. PMID: 19056883; PMCID: PMC2600759.
    59. Dejana E, Orsenigo F, Molendini C, Baluk P, McDonald D. Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees. Cell Tissue Res. 2009 Jan; 335(1):17-25. PMID: 18855014; PMCID: PMC4422058.
    60. Korpisalo P, Karvinen H, Rissanen TT, Kilpijoki J, Marjomäki V, Baluk P, McDonald D, Cao Y, Eriksson U, Alitalo K, Ylä-Herttuala S. Vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic vessels. Circ Res. 2008 Nov 07; 103(10):1092-9. PMID: 18832750.
      View in: PubMed
    61. Cyran CC, Sennino B, Chaopathomkul B, Fu Y, Rogut VS, Shames DM, Wendland MF, McDonald D, Brasch RC. Magnetic resonance imaging for monitoring the effects of thalidomide on experimental human breast cancers. Eur Radiol. 2009 Jan; 19(1):121-31. PMID: 18665367.
      View in: PubMed
    62. Kuhnert F, Tam BY, Sennino B, Gray JT, Yuan J, Jocson A, Nayak NR, Mulligan RC, McDonald D, Kuo CJ. Soluble receptor-mediated selective inhibition of VEGFR and PDGFRbeta signaling during physiologic and tumor angiogenesis. Proc Natl Acad Sci U S A. 2008 Jul 22; 105(29):10185-90. PMID: 18632559; PMCID: PMC2474564.
    63. Cyran CC, Sennino B, Chaopathomkul B, Fu Y, Rogut V, Shames DM, Wendland MF, McDonald D, Brasch RC. Magnetic resonance imaging assays for dimethyl sulfoxide effect on cancer vasculature. Invest Radiol. 2008 May; 43(5):298-305. PMID: 18424950; PMCID: PMC4423758.
    64. Raatschen HJ, Simon GH, Fu Y, Sennino B, Shames DM, Wendland MF, McDonald D, Brasch RC. Vascular permeability during antiangiogenesis treatment: MR imaging assay results as biomarker for subsequent tumor growth in rats. Radiology. 2008 May; 247(2):391-9. PMID: 18372448; PMCID: PMC4423757.
    65. Baluk P, McDonald D. Markers for microscopic imaging of lymphangiogenesis and angiogenesis. Ann N Y Acad Sci. 2008; 1131:1-12. PMID: 18519955.
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    66. Lewis CC, Yang JY, Huang X, Banerjee SK, Blackburn MR, Baluk P, McDonald D, Blackwell TS, Nagabhushanam V, Peters W, Voehringer D, Erle DJ. Disease-specific gene expression profiling in multiple models of lung disease. Am J Respir Crit Care Med. 2008 Feb 15; 177(4):376-87. PMID: 18029791; PMCID: PMC2258439.
    67. Baluk P, Fuxe J, Hashizume H, Romano T, Lashnits E, Butz S, Vestweber D, Corada M, Molendini C, Dejana E, McDonald D. Functionally specialized junctions between endothelial cells of lymphatic vessels. J Exp Med. 2007 Oct 01; 204(10):2349-62. PMID: 17846148; PMCID: PMC2118470.
    68. Sennino B, Falcón BL, McCauley D, Le T, McCauley T, Kurz JC, Haskell A, Epstein DM, McDonald D. Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102. Cancer Res. 2007 Aug 01; 67(15):7358-67. PMID: 17671206; PMCID: PMC4422164.
    69. Ocak I, Baluk P, Barrett T, McDonald D, Choyke P. The biologic basis of in vivo angiogenesis imaging. Front Biosci. 2007 May 01; 12:3601-16. PMID: 17485324.
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    70. Henning TD, Saborowski O, Golovko D, Boddington S, Bauer JS, Fu Y, Meier R, Pietsch H, Sennino B, McDonald D, Daldrup-Link HE. Cell labeling with the positive MR contrast agent Gadofluorine M. Eur Radiol. 2007 May; 17(5):1226-34. PMID: 17206428.
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    71. Kim KE, Cho CH, Kim HZ, Baluk P, McDonald D, Koh GY. In vivo actions of angiopoietins on quiescent and remodeling blood and lymphatic vessels in mouse airways and skin. Arterioscler Thromb Vasc Biol. 2007 Mar; 27(3):564-70. PMID: 17194894.
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    72. Daly C, Pasnikowski E, Burova E, Wong V, Aldrich TH, Griffiths J, Ioffe E, Daly TJ, Fandl JP, Papadopoulos N, McDonald D, Thurston G, Yancopoulos GD, Rudge JS. Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15491-6. PMID: 17030814; PMCID: PMC1592534.
    73. Mancuso MR, Davis R, Norberg SM, O'Brien S, Sennino B, Nakahara T, Yao VJ, Inai T, Brooks P, Freimark B, Shalinsky DR, Hu-Lowe DD, McDonald D. Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J Clin Invest. 2006 Oct; 116(10):2610-21. PMID: 17016557; PMCID: PMC1578604.
    74. Bhandari V, Choo-Wing R, Chapoval SP, Lee CG, Tang C, Kim YK, Ma B, Baluk P, Lin MI, McDonald D, Homer RJ, Sessa WC, Elias JA. Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proc Natl Acad Sci U S A. 2006 Jul 18; 103(29):11021-6. PMID: 16832062; PMCID: PMC1544167.
    75. McDonald D, Vogelstein B, King MC, Hong WK, Augustin H, Hanahan D, Lippman M. Wanted: cancer boss. Nature. 2006 Apr 20; 440(7087):978-9. PMID: 16625165.
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    76. Yao VJ, Ozawa MG, Varner AS, Kasman IM, Chanthery YH, Pasqualini R, Arap W, McDonald D. Antiangiogenic therapy decreases integrin expression in normalized tumor blood vessels. Cancer Res. 2006 Mar 01; 66(5):2639-49. PMID: 16510583.
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    77. Nakahara T, Norberg SM, Shalinsky DR, Hu-Lowe DD, McDonald D. Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors. Cancer Res. 2006 Feb 01; 66(3):1434-45. PMID: 16452199.
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    78. Ramakrishnan V, Bhaskar V, Law DA, Wong MH, DuBridge RB, Breinberg D, O'Hara C, Powers DB, Liu G, Grove J, Hevezi P, Cass KM, Watson S, Evangelista F, Powers RA, Finck B, Wills M, Caras I, Fang Y, McDonald D, Johnson D, Murray R, Jeffry U. Preclinical evaluation of an anti-alpha5beta1 integrin antibody as a novel anti-angiogenic agent. J Exp Ther Oncol. 2006; 5(4):273-86. PMID: 17024968.
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    79. McDonald D, Baluk P. Imaging of angiogenesis in inflamed airways and tumors: newly formed blood vessels are not alike and may be wildly abnormal: Parker B. Francis lecture. Chest. 2005 Dec; 128(6 Suppl):602S-608S. PMID: 16373858.
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    80. Aurora AB, Baluk P, Zhang D, Sidhu SS, Dolganov GM, Basbaum C, McDonald D, Killeen N. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. J Immunol. 2005 Nov 15; 175(10):6319-26. PMID: 16272283.
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    81. Ozawa MG, Yao VJ, Chanthery YH, Troncoso P, Uemura A, Varner AS, Kasman IM, Pasqualini R, Arap W, McDonald D. Angiogenesis with pericyte abnormalities in a transgenic model of prostate carcinoma. Cancer. 2005 Nov 15; 104(10):2104-15. PMID: 16208706.
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    82. Xu X, Zhang D, Lyubynska N, Wolters PJ, Killeen NP, Baluk P, McDonald D, Hawgood S, Caughey GH. Mast cells protect mice from Mycoplasma pneumonia. Am J Respir Crit Care Med. 2006 Jan 15; 173(2):219-25. PMID: 16210667; PMCID: PMC2662990.
    83. Baffert F, Le T, Sennino B, Thurston G, Kuo CJ, Hu-Lowe D, McDonald D. Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling. Am J Physiol Heart Circ Physiol. 2006 Feb; 290(2):H547-59. PMID: 16172161.
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    84. Kamba T, Tam BY, Hashizume H, Haskell A, Sennino B, Mancuso MR, Norberg SM, O'Brien SM, Davis RB, Gowen LC, Anderson KD, Thurston G, Joho S, Springer ML, Kuo CJ, McDonald D. VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol. 2006 Feb; 290(2):H560-76. PMID: 16172168.
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    85. Baffert F, Le T, Thurston G, McDonald D. Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules. Am J Physiol Heart Circ Physiol. 2006 Jan; 290(1):H107-18. PMID: 16126815.
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    86. di Tomaso E, Capen D, Haskell A, Hart J, Logie JJ, Jain RK, McDonald D, Jones R, Munn LL. Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers. Cancer Res. 2005 Jul 01; 65(13):5740-9. PMID: 15994949.
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    87. Parsons-Wingerter P, Kasman IM, Norberg S, Magnussen A, Zanivan S, Rissone A, Baluk P, Favre CJ, Jeffry U, Murray R, McDonald D. Uniform overexpression and rapid accessibility of alpha5beta1 integrin on blood vessels in tumors. Am J Pathol. 2005 Jul; 167(1):193-211. PMID: 15972964; PMCID: PMC1603436.
    88. Cho CH, Kim KE, Byun J, Jang HS, Kim DK, Baluk P, Baffert F, Lee GM, Mochizuki N, Kim J, Jeon BH, McDonald D, Koh GY. Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow. Circ Res. 2005 Jul 08; 97(1):86-94. PMID: 15961719.
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    89. Thurston G, Wang Q, Baffert F, Rudge J, Papadopoulos N, Jean-Guillaume D, Wiegand S, Yancopoulos GD, McDonald D. Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period. Development. 2005 Jul; 132(14):3317-26. PMID: 15958513.
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    90. Magnussen A, Kasman IM, Norberg S, Baluk P, Murray R, McDonald D. Rapid access of antibodies to alpha5beta1 integrin overexpressed on the luminal surface of tumor blood vessels. Cancer Res. 2005 Apr 01; 65(7):2712-21. PMID: 15805270.
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    91. Baluk P, Tammela T, Ator E, Lyubynska N, Achen MG, Hicklin DJ, Jeltsch M, Petrova TV, Pytowski B, Stacker SA, Ylä-Herttuala S, Jackson DG, Alitalo K, McDonald D. Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. J Clin Invest. 2005 Feb; 115(2):247-57. PMID: 15668734; PMCID: PMC544601.
    92. Yao VJ, Ozawa MG, Trepel M, Arap W, McDonald D, Pasqualini R. Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissection. Am J Pathol. 2005 Feb; 166(2):625-36. PMID: 15681844; PMCID: PMC1602338.
    93. Baluk P, Hashizume H, McDonald D. Cellular abnormalities of blood vessels as targets in cancer. Curr Opin Genet Dev. 2005 Feb; 15(1):102-11. PMID: 15661540.
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    94. Inai T, Mancuso MR, McDonald D, Kobayashi J, Nakamura K, Shibata Y. Shear stress-induced upregulation of connexin 43 expression in endothelial cells on upstream surfaces of rat cardiac valves. Histochem Cell Biol. 2004 Nov; 122(5):477-83. PMID: 15558296.
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    95. Baluk P, Lee CG, Link H, Ator E, Haskell A, Elias JA, McDonald D. Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airways. Am J Pathol. 2004 Oct; 165(4):1071-85. PMID: 15466375; PMCID: PMC1618646.
    96. Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, Kang MJ, Cohn L, Kim YK, McDonald D, Elias JA. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med. 2004 Oct; 10(10):1095-103. PMID: 15378055; PMCID: PMC3434232.
    97. Inai T, Mancuso M, Hashizume H, Baffert F, Haskell A, Baluk P, Hu-Lowe DD, Shalinsky DR, Thurston G, Yancopoulos GD, McDonald D. Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol. 2004 Jul; 165(1):35-52. PMID: 15215160; PMCID: PMC1618540.
    98. Baluk P, Raymond WW, Ator E, Coussens LM, McDonald D, Caughey GH. Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodeling. Am J Physiol Lung Cell Mol Physiol. 2004 Aug; 287(2):L307-17. PMID: 15075248.
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    99. Baffert F, Thurston G, Rochon-Duck M, Le T, Brekken R, McDonald D. Age-related changes in vascular endothelial growth factor dependency and angiopoietin-1-induced plasticity of adult blood vessels. Circ Res. 2004 Apr 16; 94(7):984-92. PMID: 15001532.
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    100. McDonald D, Teicher BA, Stetler-Stevenson W, Ng SS, Figg WD, Folkman J, Hanahan D, Auerbach R, O'Reilly M, Herbst R, Cheresh D, Gordon M, Eggermont A, Libutti SK. Report from the society for biological therapy and vascular biology faculty of the NCI workshop on angiogenesis monitoring. J Immunother. 2004 Mar-Apr; 27(2):161-75. PMID: 14770088.
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    101. Ozawa CR, Banfi A, Glazer NL, Thurston G, Springer ML, Kraft PE, McDonald D, Blau HM. Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis. J Clin Invest. 2004 Feb; 113(4):516-27. PMID: 14966561; PMCID: PMC338257.
    102. Baluk P, Morikawa S, Haskell A, Mancuso M, McDonald D. Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors. Am J Pathol. 2003 Nov; 163(5):1801-15. PMID: 14578181; PMCID: PMC1892429.
    103. Denis-Mize KS, Dupuis M, Singh M, Woo C, Ugozzoli M, O'Hagan DT, Donnelly JJ, Ott G, McDonald D. Mechanisms of increased immunogenicity for DNA-based vaccines adsorbed onto cationic microparticles. Cell Immunol. 2003 Sep; 225(1):12-20. PMID: 14643300.
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    104. Favre CJ, Mancuso M, Maas K, McLean JW, Baluk P, McDonald D. Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung. Am J Physiol Heart Circ Physiol. 2003 Nov; 285(5):H1917-38. PMID: 12842817.
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    105. McDonald D, Choyke PL. Imaging of angiogenesis: from microscope to clinic. Nat Med. 2003 Jun; 9(6):713-25. PMID: 12778170.
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    106. Umemoto EY, Brokaw JJ, Dupuis M, McDonald D. Rapid changes in shape and number of MHC class II expressing cells in rat airways after Mycoplasma pulmonis infection. Cell Immunol. 2002 Dec; 220(2):107-15. PMID: 12657245.
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    107. Pasqualini R, Arap W, McDonald D. Probing the structural and molecular diversity of tumor vasculature. Trends Mol Med. 2002 Dec; 8(12):563-71. PMID: 12470989.
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    108. McDonald D, Baluk P. Significance of blood vessel leakiness in cancer. Cancer Res. 2002 Sep 15; 62(18):5381-5. PMID: 12235011.
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    109. Morikawa S, Baluk P, Kaidoh T, Haskell A, Jain RK, McDonald D. Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am J Pathol. 2002 Mar; 160(3):985-1000. PMID: 11891196; PMCID: PMC1867175.
    110. McDonald D. Endothelial Gaps: Plasma Leakage During Inflammation. News Physiol Sci. 1998 Apr; 13:104-105. PMID: 11390771.
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