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Douglas Nixon, MD, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address1001 Potrero Ave
San Francisco CA 94110
Phone415-206-5518
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    Collapse Research 
    Collapse Research Activities and Funding
    HIV induced anti-cancer HERV immunity in prostate, breast and colon cancers
    NIH/NCI R01CA206488Aug 19, 2016 - Jul 31, 2021
    Role: Principal Investigator
    BELIEVE: Bench to Bed Enhanced Lymphocyte Infusions to Engineer Viral Eradication
    NIH/NIAID UM1AI126617Jul 14, 2016 - Jun 30, 2021
    Role: Principal Investigator
    District of Columbia Center for AIDS Research (DC CFAR)
    NIH P30AI117970Jun 1, 2015 - May 31, 2020
    Role: Co-Investigator
    A novel APOBEC-based vaccine approach for HIV
    NIH/NIAID R33AI093179Jul 1, 2014 - Jun 30, 2016
    Role: Principal Investigator
    A novel APOBEC-based vaccine approach for HIV
    NIH/NIAID R21AI093179May 4, 2011 - Apr 30, 2014
    Role: Principal Investigator
    Protective immunity in HIV Highly exposed but uninfected subjects
    NIH/NIAID R21AI087131Mar 15, 2010 - Feb 28, 2013
    Role: Principal Investigator
    An endogenous retroelement vaccine against HIV-1
    NIH/NIAID R56AI084113Sep 12, 2009 - Aug 31, 2010
    Role: Principal Investigator
    The Biology of HIV Transmission
    NIH/NIAID P01AI071713Sep 1, 2007 - Aug 31, 2013
    Role: Co-Investigator
    Elimination of HIV using HERV specific T cells
    NIH/NIAID R01AI076059Jul 1, 2007 - Jul 31, 2018
    Role: Principal Investigator
    T Regulatory Cells in HIV Infection
    NIH/NIAID R01AI068498Jul 1, 2006 - May 31, 2012
    Role: Principal Investigator
    Viral Tropism and Immune Control in HIV
    NIH/NIAID R21AI065241Jul 1, 2006 - Jun 30, 2009
    Role: Principal Investigator
    Human Natural Killer Cell Biology
    NIH/NIAID P01AI064520Sep 16, 2005 - Feb 28, 2011
    Role: Co-Investigator
    Cell Mediated Immunity in HIV Infected Children
    NIH/NIAID R01AI060379Apr 15, 2005 - Dec 31, 2011
    Role: Principal Investigator
    Cell Mediated Immunity in HIV Infected Children
    NIH/NIAID R21AI060379Apr 1, 2004 - Apr 14, 2005
    Role: Principal Investigator
    T Regulatory Cells in HIV Infection
    NIH/NIAID R21AI060407Mar 1, 2004 - Feb 28, 2007
    Role: Principal Investigator
    HIV-1 Vaccines Designed to Induce Mucosal Immunity
    NIH U19AI051596Sep 30, 2002 - Jul 31, 2007
    Role: Co-Investigator
    Innate NKT Cells in HIV Infection
    NIH/NIAID R37AI052731May 1, 2002 - Jun 30, 2017
    Role: Principal Investigator
    Innate NKT Cells in HIV Infection
    NIH/NIAID R01AI052731May 1, 2002 - Apr 30, 2007
    Role: Principal Investigator
    HIV VARIATION AND CROSS CLADE CTL RECOGNITION
    NIH/NIAID R01AI046254Sep 30, 1999 - Jun 30, 2005
    Role: Principal Investigator
    DYNAMICS OF HIV1 SPECIFIC CTL IN HIV1 INFECTION
    NIH/NIAID R01AI044595Mar 1, 1999 - Feb 28, 2005
    Role: Principal Investigator
    HIV1 SPECIFIC CELLULAR IMMUNE RESPONSES IN GALT
    NIH/NIDDK R21DK055858Sep 30, 1998 - Aug 31, 2000
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Webb GM, Li S, Mwakalundwa G, Folkvord JM, Greene JM, Reed JS, Stanton JJ, Legasse AW, Hobbs T, Martin LD, Park BS, Whitney JB, Jeng EK, Wong HC, Nixon D, Jones RB, Connick E, Skinner PJ, Sacha JB. The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles. Blood Adv. 2018 Jan 23; 2(2):76-84. PMID: 29365313.
      View in: PubMed
    2. Paquin-Proulx D, Avelino-Silva VI, Santos BAN, Silveira Barsotti N, Siroma F, Fernandes Ramos J, Coracini Tonacio A, Song A, Maestri A, Barros Cerqueira N, Felix AC, Levi JE, Greenspun BC, de Mulder Rougvie M, Rosenberg MG, Nixon D, Kallas EG. MAIT cells are activated in acute Dengue virus infection and after in vitro Zika virus infection. PLoS Negl Trop Dis. 2018 Jan; 12(1):e0006154. PMID: 29357366.
      View in: PubMed
    3. Huang SH, Ren Y, Thomas AS, Chan D, Mueller S, Ward AR, Patel S, Bollard CM, Cruz CR, Karandish S, Truong R, Macedo AB, Bosque A, Kovacs C, Benko E, Piechocka-Trocha A, Wong H, Jeng E, Nixon D, Ho YC, Siliciano RF, Walker BD, Jones RB. Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells. J Clin Invest. 2018 Feb 01; 128(2):876-889. PMID: 29355843.
      View in: PubMed
    4. de Mulder M, SenGupta D, Deeks SG, Martin JN, Pilcher CD, Hecht FM, Sacha JB, Nixon D, Michaud HA. Anti-HERV-K (HML-2) capsid antibody responses in HIV elite controllers. Retrovirology. 2017 Aug 22; 14(1):41. PMID: 28830571.
      View in: PubMed
    5. Gurfein BT, Hasdemir B, Milush JM, Touma C, Palme R, Nixon D, Darcel N, Hecht FM, Bhargava A. Enriched environment and stress exposure influence splenic B lymphocyte composition. PLoS One. 2017; 12(7):e0180771. PMID: 28704473.
      View in: PubMed
    6. Paquin-Proulx D, Leal FE, Terrassani Silveira CG, Maestri A, Brockmeyer C, Kitchen SM, Cabido VD, Kallas EG, Nixon D. T-cell Responses in Individuals Infected with Zika Virus and in Those Vaccinated Against Dengue Virus. Pathog Immun. 2017; 2(2):274-292. PMID: 28835931.
      View in: PubMed
    7. Ribeiro SP, Milush JM, Cunha-Neto E, Kallas EG, Kalil J, Passero LFD, Hunt PW, Deeks SG, Nixon D, SenGupta D. Correction: p16INK4a Expression and Immunologic Aging in Chronic HIV Infection. PLoS One. 2017; 12(4):e0176509. PMID: 28426830.
      View in: PubMed
    8. Paquin-Proulx D, Greenspun BC, Costa EA, Segurado AC, Kallas EG, Nixon D, Leal FE. MAIT cells are reduced in frequency and functionally impaired in human T lymphotropic virus type 1 infection: Potential clinical implications. PLoS One. 2017; 12(4):e0175345. PMID: 28384290.
      View in: PubMed
    9. Wu JJ, Gilbert KE, Batech M, Manalo IF, Towner WJ, Raposo RA, Nixon D, Liao W. Examining HIV Viral Load in a Matched Cohort of HIV Positive Individuals With and Without Psoriasis. J Drugs Dermatol. 2017 Apr 01; 16(4):372-377. PMID: 28403272.
      View in: PubMed
    10. Menezes SM, Leal FE, Dierckx T, Khouri R, Decanine D, Silva-Santos G, Schnitman SV, Kruschewsky R, López G, Alvarez C, Talledo M, Gotuzzo E, Nixon D, Vercauteren J, Brassat D, Liblau R, Vandamme AM, Galvão-Castro B, Van Weyenbergh J. A Fashi Lymphoproliferative Phenotype Reveals Non-Apoptotic Fas Signaling in HTLV-1-Associated Neuroinflammation. Front Immunol. 2017; 8:97. PMID: 28261198.
      View in: PubMed
    11. Geddes VEV, José DP, Leal FE, Nixon D, Tanuri A, Aguiar RS. HTLV-1 Tax activates HIV-1 transcription in latency models. Virology. 2017 04; 504:45-51. PMID: 28152383.
      View in: PubMed
    12. Raposo RA, de Mulder Rougvie M, Paquin-Proulx D, Brailey PM, Cabido VD, Zdinak PM, Thomas AS, Huang SH, Beckerle GA, Jones RB, Nixon D. IFITM1 targets HIV-1 latently infected cells for antibody-dependent cytolysis. JCI Insight. 2017 Jan 12; 2(1):e85811. PMID: 28097226.
      View in: PubMed
    13. Ornelas AM, Pezzuto P, Silveira PP, Melo FO, Ferreira TA, Oliveira-Szejnfeld PS, Leal JI, Amorim MM, Hamilton S, Rawlinson WD, Cardoso CC, Nixon D, Tanuri A, Melo AS, Aguiar RS. Immune activation in amniotic fluid from Zika virus-associated microcephaly. Ann Neurol. 2017 Jan; 81(1):152-156. PMID: 27977881.
      View in: PubMed
    14. Ribeiro SP, Milush JM, Cunha-Neto E, Kallas EG, Kalil J, Passero LFD, Hunt PW, Deeks SG, Nixon D, SenGupta D. p16INK4a Expression and Immunologic Aging in Chronic HIV Infection. PLoS One. 2016; 11(11):e0166759. PMID: 27861555.
      View in: PubMed
    15. Nititham J, Gupta R, Zeng X, Hartogensis W, Nixon D, Deeks SG, Hecht FM, Liao W. Psoriasis risk SNPs and their association with HIV-1 control. Hum Immunol. 2017 Feb; 78(2):179-184. PMID: 27810495.
      View in: PubMed
    16. Paquin-Proulx D, Gibbs A, Bächle SM, Checa A, Introini A, Leeansyah E, Wheelock CE, Nixon D, Broliden K, Tjernlund A, Moll M, Sandberg JK. Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion. J Immunol. 2016 09 01; 197(5):1843-51. PMID: 27481843; PMCID: PMC4991248.
    17. Willberg CB, Garrison KE, Jones RB, Meiklejohn DA, Spotts G, Liegler TJ, Ostrowski MA, Karlsson AC, Hecht FM, Nixon D. Correction: Rapid Progressing Allele HLA-B35 Px Restricted Anti-HIV-1 CD8+ T Cells Recognize Vestigial CTL Epitopes. PLoS One. 2016; 11(7):e0160293. PMID: 27454121.
      View in: PubMed
    18. Paquin-Proulx D, Barsotti NS, Santos BA, Marinho AK, Kokron CM, Carvalho KI, Barros MT, Kalil J, Nixon D, Kallas EG. Inversion of the Vd1 to Vd2 ?d T cell ratio in CVID is not restored by IVIg and is associated with immune activation and exhaustion. Medicine (Baltimore). 2016 Jul; 95(30):e4304. PMID: 27472706.
      View in: PubMed
    19. Patel S, Jones RB, Nixon D, Bollard CM. T-cell therapies for HIV: Preclinical successes and current clinical strategies. Cytotherapy. 2016 08; 18(8):931-42. PMID: 27265874.
      View in: PubMed
    20. Kuebler PJ, Shaw BI, Leadabrand KS, Mehrotra ML, Grant RM, Kallás EG, Nixon D. Brief Report: HIV-1 gp120 T-Cell Responses Correspond to Infection Outcomes in the Global iPrEx Chemoprophylaxis Trial. J Acquir Immune Defic Syndr. 2016 Jun 01; 72(2):184-8. PMID: 26674373.
      View in: PubMed
    21. Daubenmier J, Moran PJ, Kristeller J, Acree M, Bacchetti P, Kemeny ME, Dallman M, Lustig RH, Grunfeld C, Nixon D, Milush JM, Goldman V, Laraia B, Laugero KD, Woodhouse L, Epel ES, Hecht FM. Effects of a mindfulness-based weight loss intervention in adults with obesity: A randomized clinical trial. Obesity (Silver Spring). 2016 Apr; 24(4):794-804. PMID: 26955895; PMCID: PMC4898945 [Available on 04/01/17].
    22. Kuebler PJ, Mehrotra ML, Shaw BI, Leadabrand KS, Milush JM, York VA, Defechereux P, Grant RM, Kallás EG, Nixon D. Persistent HIV Type 1 Seronegative Status Is Associated With Lower CD8+ T-Cell Activation. J Infect Dis. 2016 Feb 15; 213(4):569-73. PMID: 26310308; PMCID: PMC4721903 [Available on 02/15/17].
    23. Kuebler PJ, Mehrotra ML, McConnell JJ, Holditch SJ, Shaw BI, Tarosso LF, Leadabrand KS, Milush JM, York VA, Raposo RA, Cheng RG, Eriksson EM, McMahan V, Glidden DV, Shiboski S, Grant RM, Nixon D, Kallás EG. Cellular immune correlates analysis of an HIV-1 preexposure prophylaxis trial. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):8379-84. PMID: 26100867; PMCID: PMC4500209.
    24. Almeida RR, Raposo RA, Coirada FC, da Silva JR, de Souza Ferreira LC, Kalil J, Nixon D, Cunha-Neto E. Modulating APOBEC expression enhances DNA vaccine immunogenicity. Immunol Cell Biol. 2015 Nov; 93(10):868-76. PMID: 25953029.
      View in: PubMed
    25. Eriksson EM, Liegler T, Keh CE, Karlsson AC, Holditch SJ, Pilcher CD, Loeb L, Nixon D, Hecht FM. Newly Exerted T Cell Pressures on Mutated Epitopes following Transmission Help Maintain Consensus HIV-1 Sequences. PLoS One. 2014; 10(4):e0120787. PMID: 25919393; PMCID: PMC4412704.
    26. Nixon D, Simon GL, Raposo RA. Test, treat, and cure. J Acquir Immune Defic Syndr. 2015 Jan 01; 68(1):e9-10. PMID: 25296100; PMCID: PMC4435739.
    27. Leal FE, Michniowski M, Nixon D. Human T-lymphotropic virus 1, breastfeeding, and antiretroviral therapy. AIDS Res Hum Retroviruses. 2015 Mar; 31(3):271. PMID: 25296330.
      View in: PubMed
    28. Ribeiro SP, Milush JM, Cunha-Neto E, Kallas EG, Kalil J, Somsouk M, Hunt PW, Deeks SG, Nixon D, SenGupta D. The CD8? memory stem T cell (T(SCM)) subset is associated with improved prognosis in chronic HIV-1 infection. J Virol. 2014 Dec; 88(23):13836-44. PMID: 25253339; PMCID: PMC4248986.
    29. Gupta R, Michaud HA, Zeng X, Debbaneh M, Arron ST, Jones RB, Ormsby CE, Nixon D, Liao W. Diminished humoral responses against and reduced gene expression levels of human endogenous retrovirus-K (HERV-K) in psoriasis. J Transl Med. 2014 Sep 16; 12:256. PMID: 25224121; PMCID: PMC4174287.
    30. Raposo RA, Abdel-Mohsen M, Deng X, Hecht FM, Pilcher CD, Pillai SK, Nixon D. Dynamic regulation of host restriction factor expression over the course of HIV-1 infection in vivo. J Virol. 2014 Oct; 88(19):11624-9. PMID: 25031350; PMCID: PMC4178813.
    31. Michaud HA, SenGupta D, de Mulder M, Deeks SG, Martin JN, Kobie JJ, Sacha JB, Nixon D. Cutting edge: An antibody recognizing ancestral endogenous virus glycoproteins mediates antibody-dependent cellular cytotoxicity on HIV-1-infected cells. J Immunol. 2014 Aug 15; 193(4):1544-8. PMID: 25024383; PMCID: PMC4120895.
    32. Gurfein BT, Davidenko O, Premenko-Lanier M, Milush JM, Acree M, Dallman MF, Touma C, Palme R, York VA, Fromentin G, Darcel N, Nixon D, Hecht FM. Environmental enrichment alters splenic immune cell composition and enhances secondary influenza vaccine responses in mice. Mol Med. 2014 Apr 22; 20:179-90. PMID: 24687160; PMCID: PMC4002849.
    33. Sheppard NC, Jones RB, Burwitz BJ, Nimityongskul FA, Newman LP, Buechler MB, Reed JS, Piaskowski SM, Weisgrau KL, Castrovinci PA, Wilson NA, Ostrowski MA, Park B, Nixon D, Rakasz EG, Sacha JB. Vaccination against endogenous retrotransposable element consensus sequences does not protect rhesus macaques from SIVsmE660 infection and replication. PLoS One. 2014; 9(3):e92012. PMID: 24651676; PMCID: PMC3961289.
    34. Michaud HA, de Mulder M, SenGupta D, Deeks SG, Martin JN, Pilcher CD, Hecht FM, Sacha JB, Nixon D. Trans-activation, post-transcriptional maturation, and induction of antibodies to HERV-K (HML-2) envelope transmembrane protein in HIV-1 infection. Retrovirology. 2014 Jan 28; 11:10. PMID: 24472118; PMCID: PMC3907665.
    35. Emu B, Moretto WJ, Hoh R, Krone M, Martin JN, Nixon D, Deeks SG, McCune JM. Composition and function of T cell subpopulations are slow to change despite effective antiretroviral treatment of HIV disease. PLoS One. 2014; 9(1):e85613. PMID: 24465619; PMCID: PMC3897457.
    36. Leeansyah E, Loh L, Nixon D, Sandberg JK. Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development. Nat Commun. 2014; 5:3143. PMID: 24452018; PMCID: PMC3916833.
    37. Milush JM, López-Vergès S, York VA, Deeks SG, Martin JN, Hecht FM, Lanier LL, Nixon D. CD56negCD16? NK cells are activated mature NK cells with impaired effector function during HIV-1 infection. Retrovirology. 2013 Dec 18; 10:158. PMID: 24351015; PMCID: PMC3892122.
    38. Abdel-Mohsen M, Raposo RA, Deng X, Li M, Liegler T, Sinclair E, Salama MS, Ghanem Hel-D, Hoh R, Wong JK, David M, Nixon D, Deeks SG, Pillai SK. Expression profile of host restriction factors in HIV-1 elite controllers. Retrovirology. 2013 Oct 16; 10:106. PMID: 24131498; PMCID: PMC3827935.
    39. Jones RB, Song H, Xu Y, Garrison KE, Buzdin AA, Anwar N, Hunter DV, Mujib S, Mihajlovic V, Martin E, Lee E, Kuciak M, Raposo RA, Bozorgzad A, Meiklejohn DA, Ndhlovu LC, Nixon D, Ostrowski MA. LINE-1 retrotransposable element DNA accumulates in HIV-1-infected cells. J Virol. 2013 Dec; 87(24):13307-20. PMID: 24089548; PMCID: PMC3838212.
    40. Raposo RA, Abdel-Mohsen M, Bilska M, Montefiori DC, Nixon D, Pillai SK. Effects of cellular activation on anti-HIV-1 restriction factor expression profile in primary cells. J Virol. 2013 Nov; 87(21):11924-9. PMID: 23966394; PMCID: PMC3807358.
    41. Ivarsson MA, Loh L, Marquardt N, Kekäläinen E, Berglin L, Björkström NK, Westgren M, Nixon D, Michaëlsson J. Differentiation and functional regulation of human fetal NK cells. J Clin Invest. 2013 Sep; 123(9):3889-901. PMID: 23945237; PMCID: PMC3754261.
    42. Raposo RA, Abdel-Mohsen M, Holditch SJ, Kuebler PJ, Cheng RG, Eriksson EM, Liao W, Pillai SK, Nixon D. Increased expression of intrinsic antiviral genes in HLA-B*57-positive individuals. J Leukoc Biol. 2013 Nov; 94(5):1051-9. PMID: 23929683; PMCID: PMC3800066.
    43. Snyder-Cappione JE, Nixon D, Chi JC, Nguyen ML, Kirby CK, Milush JM, Koth LL. Invariant natural killer T (iNKT) cell exhaustion in sarcoidosis. Eur J Immunol. 2013 Aug; 43(8):2194-205. PMID: 23661497; PMCID: PMC3869389.
    44. Sanabani SS, Pessôa R, Soares de Oliveira AC, Martinez VP, Giret MT, de Menezes Succi RC, Carvalho K, Tomiyama CS, Nixon D, Sabino EC, Kallas EG. Variability of HIV-1 genomes among children and adolescents from São Paulo, Brazil. PLoS One. 2013; 8(5):e62552. PMID: 23667488; PMCID: PMC3646872.
    45. Champiat S, Garrison KE, Raposo RA, Burwitz BJ, Reed J, Tandon R, York VA, Newman LP, Nimityongskul FA, Wilson NA, Almeida RR, Martin JN, Deeks SG, Rosenberg MG, Wiznia AA, Spotts GE, Pilcher CD, Hecht FM, Ostrowski MA, Sacha JB, Nixon D. T cells target APOBEC3 proteins in human immunodeficiency virus type 1-infected humans and simian immunodeficiency virus-infected Indian rhesus macaques. J Virol. 2013 Jun; 87(11):6073-80. PMID: 23536679; PMCID: PMC3648095.
    46. Batista MD, Tincati C, Milush JM, Ho EL, Ndhlovu LC, York VA, Kallas EG, Kalil J, Keating SM, Norris PJ, Chang D, Unemori P, Leslie KS, Maurer T, Liao W, Nixon D. CD57 expression and cytokine production by T cells in lesional and unaffected skin from patients with psoriasis. PLoS One. 2013; 8(2):e52144. PMID: 23468834; PMCID: PMC3585296.
    47. Leal FE, Ndhlovu LC, Hasenkrug AM, Bruno FR, Carvalho KI, Wynn-Williams H, Neto WK, Sanabani SS, Segurado AC, Nixon D, Kallas EG. Expansion in CD39? CD4? immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological complications. PLoS Negl Trop Dis. 2013; 7(2):e2028. PMID: 23409198; PMCID: PMC3566991.
    48. Jones RB, Leal FE, Hasenkrug AM, Segurado AC, Nixon D, Ostrowski MA, Kallas EG. Human endogenous retrovirus K(HML-2) Gag and Env specific T-cell responses are not detected in HTLV-I-infected subjects using standard peptide screening methods. J Negat Results Biomed. 2013 Jan 10; 12:3. PMID: 23305161; PMCID: PMC3560086.
    49. Perez CL, Milush JM, Buggert M, Eriksson EM, Larsen MV, Liegler T, Hartogensis W, Bacchetti P, Lund O, Hecht FM, Nixon D, Karlsson AC. Targeting of conserved gag-epitopes in early HIV infection is associated with lower plasma viral load and slower CD4(+) T cell depletion. AIDS Res Hum Retroviruses. 2013 Mar; 29(3):602-12. PMID: 23140171; PMCID: PMC3581067.
    50. Jones RB, Garrison KE, Mujib S, Mihajlovic V, Aidarus N, Hunter DV, Martin E, John VM, Zhan W, Faruk NF, Gyenes G, Sheppard NC, Priumboom-Brees IM, Goodwin DA, Chen L, Rieger M, Muscat-King S, Loudon PT, Stanley C, Holditch SJ, Wong JC, Clayton K, Duan E, Song H, Xu Y, SenGupta D, Tandon R, Sacha JB, Brockman MA, Benko E, Kovacs C, Nixon D, Ostrowski MA. HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates. J Clin Invest. 2012 Dec; 122(12):4473-89. PMID: 23143309; PMCID: PMC3533554.
    51. Tandon R, Giret MT, Sengupta D, York VA, Wiznia AA, Rosenberg MG, Kallas EG, Ndhlovu LC, Nixon D. Age-related expansion of Tim-3 expressing T cells in vertically HIV-1 infected children. PLoS One. 2012; 7(9):e45733. PMID: 23029209; PMCID: PMC3454343.
    52. Ormsby CE, Sengupta D, Tandon R, Deeks SG, Martin JN, Jones RB, Ostrowski MA, Garrison KE, Vázquez-Pérez JA, Reyes-Terán G, Nixon D. Human endogenous retrovirus expression is inversely associated with chronic immune activation in HIV-1 infection. PLoS One. 2012; 7(8):e41021. PMID: 22879884; PMCID: PMC3413683.
    53. Champiat S, Raposo RA, Maness NJ, Lehman JL, Purtell SE, Hasenkrug AM, Miller JC, Dean H, Koff WC, Hong MA, Martin JN, Deeks SG, Spotts GE, Pilcher CD, Hecht FM, Kallas EG, Garrison KE, Nixon D. Influence of HAART on alternative reading frame immune responses over the course of HIV-1 infection. PLoS One. 2012; 7(6):e39311. PMID: 22768072; PMCID: PMC3387156.
    54. Sacha JB, Kim IJ, Chen L, Ullah JH, Goodwin DA, Simmons HA, Schenkman DI, von Pelchrzim F, Gifford RJ, Nimityongskul FA, Newman LP, Wildeboer S, Lappin PB, Hammond D, Castrovinci P, Piaskowski SM, Reed JS, Beheler KA, Tharmanathan T, Zhang N, Muscat-King S, Rieger M, Fernandes C, Rumpel K, Gardner JP, Gebhard DH, Janies J, Shoieb A, Pierce BG, Trajkovic D, Rakasz E, Rong S, McCluskie M, Christy C, Merson JR, Jones RB, Nixon D, Ostrowski MA, Loudon PT, Pruimboom-Brees IM, Sheppard NC. Vaccination with cancer- and HIV infection-associated endogenous retrotransposable elements is safe and immunogenic. J Immunol. 2012 Aug 01; 189(3):1467-79. PMID: 22745376; PMCID: PMC3401319.
    55. Sandberg JK, Andersson SK, Bächle SM, Nixon D, Moll M. HIV-1 Vpu interference with innate cell-mediated immune mechanisms. Curr HIV Res. 2012 Jun; 10(4):327-33. PMID: 22524181; PMCID: PMC3412205.
    56. Gurfein BT, Stamm AW, Bacchetti P, Dallman MF, Nadkarni NA, Milush JM, Touma C, Palme R, Di Borgo CP, Fromentin G, Lown-Hecht R, Konsman JP, Acree M, Premenko-Lanier M, Darcel N, Hecht FM, Nixon D. The calm mouse: an animal model of stress reduction. Mol Med. 2012 May 09; 18:606-17. PMID: 22398685; PMCID: PMC3388136.
    57. Carvalho KI, Bruno FR, Snyder-Cappione JE, Maeda SM, Tomimori J, Xavier MB, Haslett PA, Nixon D, Kallas EG. Lower numbers of natural killer T cells in HIV-1 and Mycobacterium leprae co-infected patients. Immunology. 2012 May; 136(1):96-102. PMID: 22269018; PMCID: PMC3372761.
    58. Lai OY, Chen H, Michaud HA, Hayashi G, Kuebler PJ, Hultman GK, Ariza ME, Williams MV, Batista MD, Nixon D, Foerster J, Bowcock AM, Liao W. Protective effect of human endogenous retrovirus K dUTPase variants on psoriasis susceptibility. J Invest Dermatol. 2012 Jul; 132(7):1833-40. PMID: 22437317; PMCID: PMC3375357.
    59. Ndhlovu LC, Lopez-Vergès S, Barbour JD, Jones RB, Jha AR, Long BR, Schoeffler EC, Fujita T, Nixon D, Lanier LL. Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity. Blood. 2012 Apr 19; 119(16):3734-43. PMID: 22383801; PMCID: PMC3335380.
    60. Chen H, Hayashi G, Lai OY, Dilthey A, Kuebler PJ, Wong TV, Martin MP, Fernandez Vina MA, McVean G, Wabl M, Leslie KS, Maurer T, Martin JN, Deeks SG, Carrington M, Bowcock AM, Nixon D, Liao W. Psoriasis patients are enriched for genetic variants that protect against HIV-1 disease. PLoS Genet. 2012 Feb; 8(2):e1002514. PMID: 22577363.
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    61. Holditch SJ, Eriksson EM, Tarosso LF, Kuebler PJ, Kallas EG, Nielsen EK, Wiznia AA, Rosenberg MG, Nixon D. Decay kinetics of HIV-1 specific T cell responses in vertically HIV-1 exposed seronegative infants. Front Immunol. 2011; 2:94. PMID: 22566883; PMCID: PMC3341962.
    62. Sharp ER, Willberg CB, Kuebler PJ, Abadi J, Fennelly GJ, Dobroszycki J, Wiznia AA, Rosenberg MG, Nixon D. Association of differentiation state of CD4+ T cells and disease progression in HIV-1 perinatally infected children. PLoS One. 2012; 7(1):e29154. PMID: 22247768; PMCID: PMC3256156.
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    89. Mold JE, Michaëlsson J, Burt TD, Muench MO, Beckerman KP, Busch MP, Lee TH, Nixon D, McCune JM. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science. 2008 Dec 05; 322(5907):1562-5. PMID: 19056990; PMCID: PMC2648820.
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    92. Michaëlsson J, Barbosa HM, Jordan KA, Chapman JM, Brunialti MK, Neto WK, Nukui Y, Sabino EC, Chieia MA, Oliveira AS, Nixon D, Kallas EG. The frequency of CD127low expressing CD4+CD25high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis. BMC Immunol. 2008 Jul 29; 9:41. PMID: 18664281; PMCID: PMC2515103.
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    96. Pérez CL, Larsen MV, Gustafsson R, Norström MM, Atlas A, Nixon D, Nielsen M, Lund O, Karlsson AC. Broadly immunogenic HLA class I supertype-restricted elite CTL epitopes recognized in a diverse population infected with different HIV-1 subtypes. J Immunol. 2008 Apr 01; 180(7):5092-100. PMID: 18354235.
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    97. Long BR, Ndhlovu LC, Oksenberg JR, Lanier LL, Hecht FM, Nixon D, Barbour JD. Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection. J Virol. 2008 May; 82(10):4785-92. PMID: 18305035; PMCID: PMC2346752.
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    117. Jordan KA, Furlan SN, Gonzalez VD, Karlsson AC, Quigley MF, Deeks SG, Rosenberg MG, Nixon D, Sandberg JK. CD8 T cell effector maturation in HIV-1-infected children. Virology. 2006 Mar 30; 347(1):117-26. PMID: 16406047.
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    129. Plana M, Garcia F, Oxenius A, Ortiz GM, Lopez A, Cruceta A, Mestre G, Fumero E, Fagard C, Sambeat MA, Segura F, Miró JM, Arnedo M, Lopalcos L, Pumarola T, Hirschel B, Phillips RE, Nixon D, Gallart T, Gatell JM. Relevance of HIV-1-specific CD4+ helper T-cell responses during structured treatment interruptions in patients with CD4+ T-cell nadir above 400/mm3. J Acquir Immune Defic Syndr. 2004 Jul 01; 36(3):791-9. PMID: 15213562.
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    130. Shacklett BL, Cox CA, Quigley MF, Kreis C, Stollman NH, Jacobson MA, Andersson J, Sandberg JK, Nixon D. Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV-1 infection. J Immunol. 2004 Jul 01; 173(1):641-8. PMID: 15210827.
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    133. Karlsson AC, Younger SR, Martin JN, Grossman Z, Sinclair E, Hunt PW, Hagos E, Nixon D, Deeks SG. Immunologic and virologic evolution during periods of intermittent and persistent low-level viremia. AIDS. 2004 Apr 30; 18(7):981-9. PMID: 15096800.
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    135. Ramsburg E, Rose NF, Marx PA, Mefford M, Nixon D, Moretto WJ, Montefiori D, Earl P, Moss B, Rose JK. Highly effective control of an AIDS virus challenge in macaques by using vesicular stomatitis virus and modified vaccinia virus Ankara vaccine vectors in a single-boost protocol. J Virol. 2004 Apr; 78(8):3930-40. PMID: 15047809; PMCID: PMC374300.
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    137. Karlsson RK, Jennes W, Page-Shafer K, Nixon D, Shacklett BL. Poorly soluble peptides can mimic authentic ELISPOT responses. J Immunol Methods. 2004 Feb 01; 285(1):89-92. PMID: 14871537.
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    138. Alexander TH, Ortiz GM, Wellons MF, Allen A, Grace EJ, Schweighardt B, Brancato J, Sandberg JK, Furlan SN, Miralles GD, Nixon D, Bartlett JA. Changes in CD4+ T-cell differentiation phenotype during structured treatment interruption in patients with chronic HIV-1 infection. J Acquir Immune Defic Syndr. 2003 Dec 15; 34(5):475-81. PMID: 14657757.
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    139. Karlsson AC, Martin JN, Younger SR, Bredt BM, Epling L, Ronquillo R, Varma A, Deeks SG, McCune JM, Nixon D, Sinclair E. Comparison of the ELISPOT and cytokine flow cytometry assays for the enumeration of antigen-specific T cells. J Immunol Methods. 2003 Dec; 283(1-2):141-53. PMID: 14659906.
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    140. Papasavvas E, Sandberg JK, Rutstein R, Moore EC, Mackiewicz A, Thiel B, Pistilli M, June RR, Jordan KA, Gross R, Maino VC, Nixon D, Montaner LJ. Presence of human immunodeficiency virus-1-specific CD4 and CD8 cellular immune responses in children with full or partial virus suppression. J Infect Dis. 2003 Sep 15; 188(6):873-82. PMID: 12964119.
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    141. Shacklett BL, Yang O, Hausner MA, Elliott J, Hultin L, Price C, Fuerst M, Matud J, Hultin P, Cox C, Ibarrondo J, Wong JT, Nixon D, Anton PA, Jamieson BD. Optimization of methods to assess human mucosal T-cell responses to HIV infection. J Immunol Methods. 2003 Aug; 279(1-2):17-31. PMID: 12969544.
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    142. Karlsson AC, Deeks SG, Barbour JD, Heiken BD, Younger SR, Hoh R, Lane M, Sällberg M, Ortiz GM, Demarest JF, Liegler T, Grant RM, Martin JN, Nixon D. Dual pressure from antiretroviral therapy and cell-mediated immune response on the human immunodeficiency virus type 1 protease gene. J Virol. 2003 Jun; 77(12):6743-52. PMID: 12767994; PMCID: PMC156163.
    143. Shacklett BL, Cox CA, Sandberg JK, Stollman NH, Jacobson MA, Nixon D. Trafficking of human immunodeficiency virus type 1-specific CD8+ T cells to gut-associated lymphoid tissue during chronic infection. J Virol. 2003 May; 77(10):5621-31. PMID: 12719554; PMCID: PMC154016.
    144. Sandberg JK, Fast NM, Jordan KA, Furlan SN, Barbour JD, Fennelly G, Dobroszycki J, Spiegel HM, Wiznia A, Rosenberg MG, Nixon D. HIV-specific CD8+ T cell function in children with vertically acquired HIV-1 infection is critically influenced by age and the state of the CD4+ T cell compartment. J Immunol. 2003 Apr 15; 170(8):4403-10. PMID: 12682278.
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    145. Sandberg JK, Bhardwaj N, Nixon D. Dominant effector memory characteristics, capacity for dynamic adaptive expansion, and sex bias in the innate Valpha24 NKT cell compartment. Eur J Immunol. 2003 Mar; 33(3):588-96. PMID: 12616479.
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    146. Aandahl EM, Sandberg JK, Beckerman KP, Taskén K, Moretto WJ, Nixon D. CD7 is a differentiation marker that identifies multiple CD8 T cell effector subsets. J Immunol. 2003 Mar 01; 170(5):2349-55. PMID: 12594257.
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    147. Nixon D, Aandahl EM, Sandberg JK. New observations on CD8 cell responses. AIDS. 2003; 17 Suppl 4:S61-5. PMID: 15080181.
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    148. Jennes W, Kestens L, Nixon D, Shacklett BL. Enhanced ELISPOT detection of antigen-specific T cell responses from cryopreserved specimens with addition of both IL-7 and IL-15--the Amplispot assay. J Immunol Methods. 2002 Dec 01; 270(1):99-108. PMID: 12379342.
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    149. Schweighardt B, Ortiz GM, Grant RM, Wellons M, Miralles GD, Kostrikis LG, Bartlett JA, Nixon D. Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions. AIDS. 2002 Nov 22; 16(17):2342-4. PMID: 12441810.
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    150. Shacklett BL, Ling B, Veazey RS, Luckay A, Moretto WJ, Wilkens DT, Hu J, Israel ZR, Nixon D, Marx PA. Boosting of SIV-specific T cell responses in rhesus macaques that resist repeated intravaginal challenge with SIVmac251. AIDS Res Hum Retroviruses. 2002 Sep 20; 18(14):1081-8. PMID: 12396459.
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    151. Keir ME, Rosenberg MG, Sandberg JK, Jordan KA, Wiznia A, Nixon D, Stoddart CA, McCune JM. Generation of CD3+CD8low thymocytes in the HIV type 1-infected thymus. J Immunol. 2002 Sep 01; 169(5):2788-96. PMID: 12193754.
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    152. Sandberg JK, Fast NM, Palacios EH, Fennelly G, Dobroszycki J, Palumbo P, Wiznia A, Grant RM, Bhardwaj N, Rosenberg MG, Nixon D. Selective loss of innate CD4(+) V alpha 24 natural killer T cells in human immunodeficiency virus infection. J Virol. 2002 Aug; 76(15):7528-34. PMID: 12097565; PMCID: PMC136353.
    153. Shacklett BL, Means RE, Larsson M, Wilkens DT, Beadle TJ, Merritt MJ, Bhardwaj N, Palumbo PE, Skurnick JH, Louria DB, Nixon D. Dendritic cell amplification of HIV type 1-specific CD8+ T cell responses in exposed, seronegative heterosexual women. AIDS Res Hum Retroviruses. 2002 Jul 20; 18(11):805-15. PMID: 12167272.
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    154. Aandahl EM, Moretto WJ, Haslett PA, Vang T, Bryn T, Tasken K, Nixon D. Inhibition of antigen-specific T cell proliferation and cytokine production by protein kinase A type I. J Immunol. 2002 Jul 15; 169(2):802-8. PMID: 12097383.
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    155. Klenerman P, Tolfvenstam T, Price DA, Nixon D, Broliden K, Oxenius A. T lymphocyte responses against human parvovirus B19: small virus, big response. Pathol Biol (Paris). 2002 Jun; 50(5):317-25. PMID: 12116850.
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    156. Larsson M, Wilkens DT, Fonteneau JF, Beadle TJ, Merritt MJ, Kost RG, Haslett PA, Cu-Uvin S, Bhardwaj N, Nixon D, Shacklett BL. Amplification of low-frequency antiviral CD8 T cell responses using autologous dendritic cells. AIDS. 2002 Jan 25; 16(2):171-80. PMID: 11807300.
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    157. Skurnick JH, Palumbo P, DeVico A, Shacklett BL, Valentine FT, Merges M, Kamin-Lewis R, Mestecky J, Denny T, Lewis GK, Lloyd J, Praschunus R, Baker A, Nixon D, Stranford S, Gallo R, Vermund SH, Louria DB. Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure. J Infect Dis. 2002 Feb 15; 185(4):428-38. PMID: 11865394; PMCID: PMC2743095.
    158. Ortiz GM, Hu J, Goldwitz JA, Chandwani R, Larsson M, Bhardwaj N, Bonhoeffer S, Ramratnam B, Zhang L, Markowitz MM, Nixon D. Residual viral replication during antiretroviral therapy boosts human immunodeficiency virus type 1-specific CD8+ T-cell responses in subjects treated early after infection. J Virol. 2002 Jan; 76(1):411-5. PMID: 11739706; PMCID: PMC135693.
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