Duke Geem, MD, PhD

TitleResident Physician
InstitutionUniversity of California San Francisco
Address550 16th. Street
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    Emory University School of Medicine, Atlanta, GAMDMedicine
    Emory University Laney Graduate School, Atlanta, GAPhDImmunology and Molecular Pathogenesis
    Boston University, Boston, MABABiology with a Specialization in Neuroscience

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ngo VL, Abo H, Maxim E, Harusato A, Geem D, Medina-Contreras O, Merlin D, Gewirtz AT, Nusrat A, Denning TL. A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage. Proc Natl Acad Sci U S A. 2018 May 14. PMID: 29760082.
      View in: PubMed
    2. Flannigan KL, Ngo VL, Geem D, Harusato A, Hirota SA, Parkos CA, Lukacs NW, Nusrat A, Gaboriau-Routhiau V, Cerf-Bensussan N, Gewirtz AT, Denning TL. IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria. Mucosal Immunol. 2017 05; 10(3):673-684. PMID: 27624780.
      View in: PubMed
    3. Geem D, Ngo V, Harusato A, Chassaing B, Gewirtz AT, Newberry RD, Denning TL. Contribution of Mesenteric Lymph Nodes and GALT to the Intestinal Foxp3+ Regulatory T-Cell Compartment. Cell Mol Gastroenterol Hepatol. 2016 May; 2(3):274-280. PMID: 27570813.
      View in: PubMed
    4. Harusato A, Geem D, Denning TL. Macrophage Isolation from the Mouse Small and Large Intestine. Methods Mol Biol. 2016; 1422:171-80. PMID: 27246032.
      View in: PubMed
    5. Medina-Contreras O, Harusato A, Nishio H, Flannigan KL, Ngo V, Leoni G, Neumann PA, Geem D, Lili LN, Ramadas RA, Chassaing B, Gewirtz AT, Kohlmeier JE, Parkos CA, Towne JE, Nusrat A, Denning TL. Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage. J Immunol. 2016 Jan 01; 196(1):34-8. PMID: 26590314; PMCID: PMC4684965 [Available on 01/01/17].
    6. Geem D, Harusato A, Flannigan K, Denning TL. Harnessing regulatory T cells for the treatment of inflammatory bowel disease. Inflamm Bowel Dis. 2015 Jun; 21(6):1409-18. PMID: 25793328; PMCID: PMC4437827.
    7. Flannigan KL, Geem D, Harusato A, Denning TL. Intestinal Antigen-Presenting Cells: Key Regulators of Immune Homeostasis and Inflammation. Am J Pathol. 2015 Jul; 185(7):1809-19. PMID: 25976247; PMCID: PMC4483458.
    8. Harusato A, Flannigan KL, Geem D, Denning TL. Phenotypic and functional profiling of mouse intestinal antigen presenting cells. J Immunol Methods. 2015 Jun; 421:20-26. PMID: 25891794; PMCID: PMC4451390.
    9. Weitkamp JH, Rosen MJ, Zhao Z, Koyama T, Geem D, Denning TL, Rock MT, Moore DJ, Halpern MD, Matta P, Denning PW. Small intestinal intraepithelial TCR?d+ T lymphocytes are present in the premature intestine but selectively reduced in surgical necrotizing enterocolitis. PLoS One. 2014; 9(6):e99042. PMID: 24905458; PMCID: PMC4048281.
    10. Geem D, Medina-Contreras O, McBride M, Newberry RD, Koni PA, Denning TL. Specific microbiota-induced intestinal Th17 differentiation requires MHC class II but not GALT and mesenteric lymph nodes. J Immunol. 2014 Jul 01; 193(1):431-8. PMID: 24899505; PMCID: PMC4097179.
    11. Laroui H, Viennois E, Xiao B, Canup BS, Geem D, Denning TL, Merlin D. Fab'-bearing siRNA TNFa-loaded nanoparticles targeted to colonic macrophages offer an effective therapy for experimental colitis. J Control Release. 2014 Jul 28; 186:41-53. PMID: 24810114; PMCID: PMC4100604.
    12. Laroui H, Geem D, Xiao B, Viennois E, Rakhya P, Denning T, Merlin D. Targeting intestinal inflammation with CD98 siRNA/PEI-loaded nanoparticles. Mol Ther. 2014 Jan; 22(1):69-80. PMID: 24025751; PMCID: PMC3978807.
    13. Geem D, Medina-Contreras O, Kim W, Huang CS, Denning TL. Isolation and characterization of dendritic cells and macrophages from the mouse intestine. J Vis Exp. 2012 May 21; (63):e4040. PMID: 22644046; PMCID: PMC3466926.
    14. Marvar PJ, Vinh A, Thabet S, Lob HE, Geem D, Ressler KJ, Harrison DG. T lymphocytes and vascular inflammation contribute to stress-dependent hypertension. Biol Psychiatry. 2012 May 01; 71(9):774-82. PMID: 22361077; PMCID: PMC3354001.
    15. Medina-Contreras O, Geem D, Laur O, Williams IR, Lira SA, Nusrat A, Parkos CA, Denning TL. CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice. J Clin Invest. 2011 Dec; 121(12):4787-95. PMID: 22045567; PMCID: PMC3226003.
    16. Denning TL, Norris BA, Medina-Contreras O, Manicassamy S, Geem D, Madan R, Karp CL, Pulendran B. Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization. J Immunol. 2011 Jul 15; 187(2):733-47. PMID: 21666057; PMCID: PMC3131424.
    17. McHugh RK, Behar E, Gutner CA, Geem D, Otto MW. Cortisol, stress, and attentional bias toward threat. Anxiety Stress Coping. 2010 Oct; 23(5):529-45. PMID: 20191400.
      View in: PubMed
    18. Tarasev M, Pinto A, Kim D, Elliott SJ, Ballou DP. The "bridging" aspartate 178 in phthalate dioxygenase facilitates interactions between the Rieske center and the iron(II)--mononuclear center. Biochemistry. 2006 Aug 29; 45(34):10208-16. PMID: 16922496; PMCID: PMC2546612.