Edmond Linossi, PhD

Title(s)Associate Specialist, Cardiovascular Research Inst
SchoolSchool of Medicine
Address555 Mission Bay Blvd South, #482
San Francisco CA 94158
PronounsHe/Him/His
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning. bioRxiv. 2024 Jul 18. Estevam GO, Linossi EM, Rao J, Macdonald CB, Ravikumar A, Chrispens KM, Capra JA, Coyote-Maestas W, Pimentel H, Collisson EA, Jura N, Fraser JS. PMID: 39071407; PMCID: PMC11275805.
      View in: PubMed   Mentions:
    2. Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain. bioRxiv. 2024 May 06. Estevam GO, Linossi EM, Macdonald CB, Espinoza CA, Michaud JM, Coyote-Maestas W, Collisson EA, Jura N, Fraser JS. PMID: 37577651; PMCID: PMC10418267.
      View in: PubMed   Mentions:
    3. Author Correction: CIS is a potent checkpoint in NK cell-mediated tumor immunity. Nat Immunol. 2024 Feb; 25(2):371-372. Delconte RB, Kolesnik TB, Dagley LF, Rautela J, Shi W, Putz EM, Stannard K, Zhang JG, Teh C, Firth M, Ushiki T, Andoniou CE, Degli-Esposti MA, Sharp PP, Sanvitale CE, Infusini G, Liau NPD, Linossi EM, Burns CJ, Carotta S, Gray DHD, Seillet C, Hutchinson DS, Belz GT, Webb AI, Alexander WS, Li SS, Bullock AN, Babon JJ, Smyth MJ, Nicholson SE, Huntington ND. PMID: 38087084.
      View in: PubMed   Mentions:    Fields:    
    4. Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nat Commun. 2023 Dec 01; 14(1):7951. Linossi EM, Li K, Veggiani G, Tan C, Dehkhoda F, Hockings C, Calleja DJ, Keating N, Feltham R, Brooks AJ, Li SS, Sidhu SS, Babon JJ, Kershaw NJ, Nicholson SE. PMID: 38040684; PMCID: PMC10692122.
      View in: PubMed   Mentions:    Fields:    
    5. Trapping Tribbles: Nanobody-assisted structure of the TRIB2 pseudokinase. Structure. 2022 11 03; 30(11):1465-1467. Santana FR, Linossi EM, Jura N. PMID: 36332608.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nat Commun. 2021 12 02; 12(1):7032. Linossi EM, Li K, Veggiani G, Tan C, Dehkhoda F, Hockings C, Calleja DJ, Keating N, Feltham R, Brooks AJ, Li SS, Sidhu SS, Babon JJ, Kershaw NJ, Nicholson SE. PMID: 34857742; PMCID: PMC8640019.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    7. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. Res Sq. 2021 May 19. Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, Owens TW, Peters JK, Rizo AN, Schulze-Gahmen U, Smith AM, Young ID, Yu Z, Asarnow D, Billesbølle C, Campbell MG, Chen J, Chen KH, Chio US, Dickinson MS, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez KE, Mancino A, Moss FR, Paul MD, Pawar KI, Pelin A, Pospiech TH, Puchades C, Remesh SG, Safari M, Schaefer K, Sun M, Tabios MC, Thwin AC, Titus EW, Trenker R, Tse E, Tsui TKM, Wang F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, QCRG Structural Biology Consortium, Agard DA, Cheng Y, Fraser JS, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Swaney DL, Krogan NJ, Frost A, Rosenberg OS, Verba KA. PMID: 34031651; PMCID: PMC8142659.
      View in: PubMed   Mentions: 1  
    8. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. bioRxiv. 2021 May 11. Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, Owens TW, Peters JK, Rizo AN, Schulze-Gahmen U, Smith AM, Young ID, Yu Z, Asarnow D, Billesbølle C, Campbell MG, Chen J, Chen KH, Chio US, Dickinson MS, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez KE, Mancino A, Moss FR, Paul MD, Pawar KI, Pelin A, Pospiech TH, Puchades C, Remesh SG, Safari M, Schaefer K, Sun M, Tabios MC, Thwin AC, Titus EW, Trenker R, Tse E, Tsui TKM, Wang F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, QCRG Structural Biology Consortium, Agard DA, Cheng Y, Fraser JS, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Swaney DL, Krogan NJ, Frost A, Rosenberg OS, Verba KA. PMID: 34013269; PMCID: PMC8132225.
      View in: PubMed   Mentions: 4  
    9. State of the structure address on MET receptor activation by HGF. Biochem Soc Trans. 2021 04 30; 49(2):645-661. Linossi EM, Estevam GO, Oshima M, Fraser JS, Collisson EA, Jura N. PMID: 33860789; PMCID: PMC8711257.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    10. A survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics. Sci Rep. 2021 04 28; 11(1):9161. Knox J, Joly N, Linossi EM, Carmona-Negrón JA, Jura N, Pintard L, Zuercher W, Roy PJ. PMID: 33911106; PMCID: PMC8080662.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    11. Understanding SOCS protein specificity. Growth Factors. 2018 08; 36(3-4):104-117. Linossi EM, Calleja DJ, Nicholson SE. PMID: 30318950.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    12. Identification of a second binding site on the TRIM25 B30.2 domain. Biochem J. 2018 01 23; 475(2):429-440. D'Cruz AA, Kershaw NJ, Hayman TJ, Linossi EM, Chiang JJ, Wang MK, Dagley LF, Kolesnik TB, Zhang JG, Masters SL, Griffin MDW, Gack MU, Murphy JM, Nicola NA, Babon JJ, Nicholson SE. PMID: 29259080; PMCID: PMC6200327.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    13. Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling. Elife. 2017 02 14; 6. Kedzierski L, Tate MD, Hsu AC, Kolesnik TB, Linossi EM, Dagley L, Dong Z, Freeman S, Infusini G, Starkey MR, Bird NL, Chatfield SM, Babon JJ, Huntington N, Belz G, Webb A, Wark PA, Nicola NA, Xu J, Kedzierska K, Hansbro PM, Nicholson SE. PMID: 28195529; PMCID: PMC5354519.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    14. Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7. Cereb Cortex. 2017 01 01; 27(1):576-588. Lawrenson ID, Krebs DL, Linossi EM, Zhang JG, McLennan TJ, Collin C, McRae HM, Kolesnik TB, Koh K, Britto JM, Kueh AJ, Sheikh BN, El-Saafin F, Nicola NA, Tan SS, Babon JJ, Nicholson SE, Alexander WS, Thomas T, Voss AK. PMID: 26503265.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    15. CIS is a potent checkpoint in NK cell-mediated tumor immunity. Nat Immunol. 2016 07; 17(7):816-24. Delconte RB, Kolesnik TB, Dagley LF, Rautela J, Shi W, Putz EM, Stannard K, Zhang JG, Teh C, Firth M, Ushiki T, Andoniou CE, Degli-Esposti MA, Sharp PP, Sanvitale CE, Infusini G, Liau NP, Linossi EM, Burns CJ, Carotta S, Gray DH, Seillet C, Hutchinson DS, Belz GT, Webb AI, Alexander WS, Li SS, Bullock AN, Babon JJ, Smyth MJ, Nicholson SE, Huntington ND. PMID: 27213690.
      View in: PubMed   Mentions: 179     Fields:    Translation:AnimalsCells
    16. Structure and Functional Characterization of the Conserved JAK Interaction Region in the Intrinsically Disordered N-Terminus of SOCS5. Biochemistry. 2015 Aug 04; 54(30):4672-82. Chandrashekaran IR, Mohanty B, Linossi EM, Dagley LF, Leung EW, Murphy JM, Babon JJ, Nicholson SE, Norton RS. PMID: 26173083.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    17. Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling (SOCS) proteins. Immunol Rev. 2015 Jul; 266(1):123-33. Linossi EM, Nicholson SE. PMID: 26085211.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    18. Key role of suppressor of cytokine signaling 3 in regulating gp130 cytokine-induced signaling and limiting chondrocyte responses during murine inflammatory arthritis. Arthritis Rheumatol. 2014 Sep; 66(9):2391-402. Liu X, Croker BA, Campbell IK, Gauci SJ, Alexander WS, Tonkin BA, Walsh NC, Linossi EM, Nicholson SE, Lawlor KE, Wicks IP. PMID: 24839265.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    19. Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection. PLoS Pathog. 2014 May; 10(5):e1004134. Kedzierski L, Linossi EM, Kolesnik TB, Day EB, Bird NL, Kile BT, Belz GT, Metcalf D, Nicola NA, Kedzierska K, Nicholson SE. PMID: 24809749; PMCID: PMC4014316.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    20. Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1. PLoS One. 2013; 8(8):e70536. Linossi EM, Chandrashekaran IR, Kolesnik TB, Murphy JM, Webb AI, Willson TA, Kedzierski L, Bullock AN, Babon JJ, Norton RS, Nicola NA, Nicholson SE. PMID: 23990909; PMCID: PMC3749136.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    21. Suppression of cytokine signaling: the SOCS perspective. Cytokine Growth Factor Rev. 2013 Jun; 24(3):241-8. Linossi EM, Babon JJ, Hilton DJ, Nicholson SE. PMID: 23545160; PMCID: PMC3816980.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    22. The SOCS box-adapting proteins for ubiquitination and proteasomal degradation. IUBMB Life. 2012 Apr; 64(4):316-23. Linossi EM, Nicholson SE. PMID: 22362562.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
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