Elif Karagoz, PhD

Title(s)Postdoctoral Research Assoc., Howard Hughes Medical Instit
SchoolSchool of Medicine
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    1. Karagöz GE, Acosta-Alvear D, Nguyen HT, Lee CP, Chu F, Walter P. An unfolded protein-induced conformational switch activates mammalian IRE1. Elife. 2017 10 03; 6. PMID: 28971800.
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    2. Karagöz GE, Rüdiger SG. Hsp90 interaction with clients. Trends Biochem Sci. 2015 Feb; 40(2):117-25. PMID: 25579468.
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    3. Karagöz GE, Duarte AM, Akoury E, Ippel H, Biernat J, Morán Luengo T, Radli M, Didenko T, Nordhues BA, Veprintsev DB, Dickey CA, Mandelkow E, Zweckstetter M, Boelens R, Madl T, Rüdiger SG. Hsp90-Tau complex reveals molecular basis for specificity in chaperone action. Cell. 2014 Feb 27; 156(5):963-74. PMID: 24581495; PMCID: PMC4263503.
    4. Suijkerbuijk SJ, van Dam TJ, Karagöz GE, von Castelmur E, Hubner NC, Duarte AM, Vleugel M, Perrakis A, Rüdiger SG, Snel B, Kops GJ. The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase. Dev Cell. 2012 Jun 12; 22(6):1321-9. PMID: 22698286.
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    5. Li Y, Karagöz GE, Seo YH, Zhang T, Jiang Y, Yu Y, Duarte AM, Schwartz SJ, Boelens R, Carroll K, Rüdiger SG, Sun D. Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90. J Nutr Biochem. 2012 Dec; 23(12):1617-26. PMID: 22444872; PMCID: PMC3386376.
    6. Didenko T, Duarte AM, Karagöz GE, Rüdiger SG. Hsp90 structure and function studied by NMR spectroscopy. Biochim Biophys Acta. 2012 Mar; 1823(3):636-47. PMID: 22155720.
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    7. Karagöz GE, Sinnige T, Hsieh O, Rüdiger SG. Expressed protein ligation for a large dimeric protein. Protein Eng Des Sel. 2011 Jun; 24(6):495-501. PMID: 21335434.
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    8. Karagöz GE, Duarte AM, Ippel H, Uetrecht C, Sinnige T, van Rosmalen M, Hausmann J, Heck AJ, Boelens R, Rüdiger SG. N-terminal domain of human Hsp90 triggers binding to the cochaperone p23. Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2):580-5. PMID: 21183720; PMCID: PMC3021017.
    9. Häcker I, Sander B, Golas MM, Wolf E, Karagöz E, Kastner B, Stark H, Fabrizio P, Lührmann R. Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy. Nat Struct Mol Biol. 2008 Nov; 15(11):1206-12. PMID: 18953335.
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