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Ellen Mowry, MD

TitleAssistant Clinical Professor
InstitutionUniversity of California San Francisco
DepartmentNeurology
Address350 Parnassus Avenue
San Francisco CA 94117
Phone415-476-1361
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    Collapse Overview 
    Collapse Overview
    An Assistant Professor of Neurology, Dr. Mowry is working to determine if patients with MS who have low vitamin D levels have a more aggressive disease course. She will use the unique UCSF EPIC study, which is the only one of its kind in the United States, to answer this question. In this nearly complete, five-year study that includes over 500 people with MS, extensive genetic, imaging, and clinical evaluations are performed annually, providing a wealth of information to investigators. Dr. Mowry will determine if low vitamin D levels cause people with MS to have more attacks of the disease. She will also establish if vitamin D deficiency is associated with a greater rate of brain tissue loss, which is the cause of long-term disability in MS. Finally, Dr. Mowry will explore if genes related to vitamin D metabolism are determinants of MS severity and if vitamin D is metabolized the same way in people with and without MS. This project will set the stage for a large clinical trial of vitamin D supplementation in MS. The results of Dr. Mowry’s studies will have major implications for patients with MS throughout the world, as vitamin D is an inexpensive, natural therapy that could be used even by those are unable to afford the current MS medications.


    Collapse Research 
    Collapse Research Activities and Funding
    The effect of vitamin D on the clinical and imaging course of multiple sclerosis
    NIH/NINDS K23NS067055Jun 1, 2010 - Jun 30, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Mowry EM, Azevedo CJ, McCulloch CE, Okuda DT, Lincoln RR, Waubant E, Hauser SL, Pelletier D. Body mass index, but not vitamin D status, is associated with brain volume change in MS. Neurology. 2018 Nov 14. PMID: 30429274.
      View in: PubMed
    2. Alvarez E, Mowry EM. We need to conduct clinical trials of disease-modifying therapy in pregnancy to optimize care of women with MS - Yes. Mult Scler. 2018 Oct 22; 1352458518794061. PMID: 30346221.
      View in: PubMed
    3. Caldito NG, Saidha S, Sotirchos ES, Dewey BE, Cowley NJ, Glaister J, Fitzgerald KC, Al-Louzi O, Nguyen J, Rothman A, Ogbuokiri E, Fioravante N, Feldman S, Kwakyi O, Risher H, Kimbrough D, Frohman TC, Frohman E, Balcer L, Crainiceanu C, Van Zijl PCM, Mowry EM, Reich DS, Oh J, Pham DL, Prince J, Calabresi PA. Brain and retinal atrophy in African-Americans versus Caucasian-Americans with multiple sclerosis: a longitudinal study. Brain. 2018 Oct 11. PMID: 30312381.
      View in: PubMed
    4. Matza LS, Kim K, Phillips G, Zorn K, Chan KS, Smith KC, Mowry EM. Multiple sclerosis relapse: Qualitative findings from clinician and patient interviews. Mult Scler Relat Disord. 2018 Sep 26; 27:139-146. PMID: 30384199.
      View in: PubMed
    5. Mowry EM, Hedström AK, Gianfrancesco MA, Shao X, Schaefer CA, Shen L, Bellesis KH, Briggs FBS, Olsson T, Alfredsson L, Barcellos LF. Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis. Mult Scler Relat Disord. 2018 Jun 23; 24:135-141. PMID: 30005356.
      View in: PubMed
    6. Fitzgerald KC, Vizthum D, Henry-Barron B, Schweitzer A, Cassard SD, Kossoff E, Hartman AL, Kapogiannis D, Sullivan P, Baer DJ, Mattson MP, Appel LJ, Mowry EM. Effect of intermittent vs. daily calorie restriction on changes in weight and patient-reported outcomes in people with multiple sclerosis. Mult Scler Relat Disord. 2018 May 05; 23:33-39. PMID: 29753994.
      View in: PubMed
    7. Mische LJ, Mowry EM. The Evidence for Dietary Interventions and Nutritional Supplements as Treatment Options in Multiple Sclerosis: a Review. Curr Treat Options Neurol. 2018 Mar 17; 20(4):8. PMID: 29549521.
      View in: PubMed
    8. Mowry EM, Glenn JD. The Dynamics of the Gut Microbiome in Multiple Sclerosis in Relation to Disease. Neurol Clin. 2018 Feb; 36(1):185-196. PMID: 29157399.
      View in: PubMed
    9. Shoemaker TJ, Mowry EM. A review of vitamin D supplementation as disease-modifying therapy. Mult Scler. 2018 Jan; 24(1):6-11. PMID: 29307295.
      View in: PubMed
    10. Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 2018 Feb; 17(2):162-173. PMID: 29275977.
      View in: PubMed
    11. Bhargava P, Fitzgerald KC, Calabresi PA, Mowry EM. Metabolic alterations in multiple sclerosis and the impact of vitamin D supplementation. JCI Insight. 2017 Oct 05; 2(19). PMID: 28978801.
      View in: PubMed
    12. LaRocca NG, Hudson LD, Rudick R, Amtmann D, Balcer L, Benedict R, Bermel R, Chang I, Chiaravalloti ND, Chin P, Cohen JA, Cutter GR, Davis MD, DeLuca J, Feys P, Francis G, Goldman MD, Hartley E, Kapoor R, Lublin F, Lundstrom G, Matthews PM, Mayo N, Meibach R, Miller DM, Motl RW, Mowry EM, Naismith R, Neville J, Panagoulias J, Panzara M, Phillips G, Robbins A, Sidovar MF, Smith KE, Sperling B, Uitdehaag BM, Weaver J. The MSOAC approach to developing performance outcomes to measure and monitor multiple sclerosis disability. Mult Scler. 2017 Aug 01; 1352458517723718. PMID: 28799444.
      View in: PubMed
    13. Foley RW, Tagg NT, Schindler MK, Fenton KM, Reich DS, Cortese I, Mowry EM. Recurrent natalizumab-related aseptic meningitis in a patient with multiple sclerosis. Mult Scler. 2017 Sep; 23(10):1424-1427. PMID: 28639536.
      View in: PubMed
    14. Pakpoor J, Saylor D, Izbudak I, Liu L, Mowry EM, Probasco J, Yousem DM. Follow-Up of Emergency Department MRI Scans Suggesting New Diagnosis of CNS Demyelination. AJR Am J Roentgenol. 2017 Jul; 209(1):171-175. PMID: 28463541.
      View in: PubMed
    15. Mowry EM, McArthur JC. PML in natalizumab-treated multiple sclerosis: Modeling errors and risk miscalculations. Neurology. 2017 Mar 21; 88(12):1110-1111. PMID: 28228562.
      View in: PubMed
    16. Motl RW, Mowry EM, Ehde DM, LaRocca NG, Smith KE, Costello K, Shinto L, Ng AV, Sullivan AB, Giesser B, McCully KK, Fernhall B, Bishop M, Plow M, Casaccia P, Chiaravalloti ND. Wellness and multiple sclerosis: The National MS Society establishes a Wellness Research Working Group and research priorities. Mult Scler. 2018 Mar; 24(3):262-267. PMID: 28080254.
      View in: PubMed
    17. Freund B, Mowry EM. Neuromyelitis optica unmasked by a spinal dural arteriovenous fistula. J Neuroimmunol. 2016 11 15; 300:18-20. PMID: 27806871.
      View in: PubMed
    18. Waubant E, Ponsonby AL, Pugliatti M, Hanwell H, Mowry EM, Hintzen RQ. Environmental and genetic factors in pediatric inflammatory demyelinating diseases. Neurology. 2016 Aug 30; 87(9 Suppl 2):S20-7. PMID: 27572857.
      View in: PubMed
    19. Long-term evolution of multiple sclerosis disability in the treatment era. Ann Neurol. 2016 Oct; 80(4):499-510. PMID: 27464262.
      View in: PubMed
    20. Williams TJ, Benavides DR, Patrice KA, Dalmau JO, de Ávila AL, Le DT, Lipson EJ, Probasco JC, Mowry EM. Association of Autoimmune Encephalitis With Combined Immune Checkpoint Inhibitor Treatment for Metastatic Cancer. JAMA Neurol. 2016 Aug 01; 73(8):928-33. PMID: 27271951.
      View in: PubMed
    21. Mowry EM. Haematopoietic stem cell transplants should be a second-line therapy for highly active MS - Commentary. Mult Scler. 2016 09; 22(10):1263-5. PMID: 27444561.
      View in: PubMed
    22. Glenn JD, Mowry EM. Emerging Concepts on the Gut Microbiome and Multiple Sclerosis. J Interferon Cytokine Res. 2016 Jun; 36(6):347-57. PMID: 27145057.
      View in: PubMed
    23. Graves JS, Barcellos LF, Shao X, Noble J, Mowry EM, Quach H, Belman A, Casper TC, Krupp LB, Waubant E. Genetic predictors of relapse rate in pediatric MS. Mult Scler. 2016 Oct; 22(12):1528-1535. PMID: 26769066.
      View in: PubMed
    24. Sotirchos ES, Bhargava P, Eckstein C, Van Haren K, Baynes M, Ntranos A, Gocke A, Steinman L, Mowry EM, Calabresi PA. Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis. Neurology. 2016 Jan 26; 86(4):382-90. PMID: 26718578; PMCID: PMC4776090 [Available on 01/26/17].
    25. Yeshokumar AK, Saylor D, Kornberg MD, Mowry EM. Evidence for the Importance of Vitamin D Status in Neurologic Conditions. Curr Treat Options Neurol. 2015 Dec; 17(12):51. PMID: 26538263.
      View in: PubMed
    26. Bhargava P, Steele SU, Waubant E, Revirajan NR, Marcus J, Dembele M, Cassard SD, Hollis BW, Crainiceanu C, Mowry EM. Multiple sclerosis patients have a diminished serologic response to vitamin D supplementation compared to healthy controls. Mult Scler. 2016 05; 22(6):753-60. PMID: 26286698.
      View in: PubMed
    27. Cantarel BL, Waubant E, Chehoud C, Kuczynski J, DeSantis TZ, Warrington J, Venkatesan A, Fraser CM, Mowry EM. Gut microbiota in multiple sclerosis: possible influence of immunomodulators. J Investig Med. 2015 Jun; 63(5):729-34. PMID: 25775034; PMCID: PMC4439263.
    28. Graves J, Grandhe S, Weinfurtner K, Krupp L, Belman A, Chitnis T, Ness J, Weinstock-Guttman B, Gorman M, Patterson M, Rodriguez M, Lotze T, Aaen G, Mowry EM, Rose JW, Simmons T, Casper TC, James J, Waubant E. Protective environmental factors for neuromyelitis optica. Neurology. 2014 Nov 18; 83(21):1923-9. PMID: 25339213; PMCID: PMC4248458.
    29. Bhargava P, Cassard S, Steele SU, Azevedo C, Pelletier D, Sugar EA, Waubant E, Mowry EM. The vitamin D to ameliorate multiple sclerosis (VIDAMS) trial: study design for a multicenter, randomized, double-blind controlled trial of vitamin D in multiple sclerosis. Contemp Clin Trials. 2014 Nov; 39(2):288-93. PMID: 25311447.
      View in: PubMed
    30. Bhargava P, Mowry EM. Gut microbiome and multiple sclerosis. Curr Neurol Neurosci Rep. 2014 Oct; 14(10):492. PMID: 25204849.
      View in: PubMed
    31. Maghzi AH, Revirajan N, Julian LJ, Spain R, Mowry EM, Liu S, Jin C, Green AJ, McCulloch CE, Pelletier D, Waubant E. Magnetic resonance imaging correlates of clinical outcomes in early multiple sclerosis. Mult Scler Relat Disord. 2014 Nov; 3(6):720-7. PMID: 25891551.
      View in: PubMed
    32. Bermel R, Waldman A, Mowry EM. Outcome measures in multiple sclerosis. Mult Scler Int. 2014; 2014:439375. PMID: 24883206; PMCID: PMC4026968.
    33. Waubant E, Maghzi AH, Revirajan N, Spain R, Julian L, Mowry EM, Marcus J, Liu S, Jin C, Green A, McCulloch CE, Pelletier D. A randomized controlled phase II trial of riluzole in early multiple sclerosis. Ann Clin Transl Neurol. 2014 May; 1(5):340-7. PMID: 25356404; PMCID: PMC4184685.
    34. Graves J, Vinayagasundaram U, Mowry EM, Matthews IR, Marino JA, Cheng J, Waubant E. Effects of rituximab on lymphocytes in multiple sclerosis and neuromyelitis optica. Mult Scler Relat Disord. 2014 Mar; 3(2):244-52. PMID: 25878012.
      View in: PubMed
    35. Mowry EM, Carey RF, Blasco MR, Pelletier J, Duquette P, Villoslada P, Malikova I, Roger E, Kinkel RP, McDonald J, Bacchetti P, Waubant E. Association of multiple sclerosis susceptibility variants and early attack location in the CNS. PLoS One. 2013; 8(10):e75565. PMID: 24130718; PMCID: PMC3794979.
    36. Mowry EM, Carey RF, Blasco MR, Pelletier J, Duquette P, Villoslada P, Malikova I, Roger E, Kinkel RP, McDonald J, Bacchetti P, Waubant E. Multiple sclerosis susceptibility genes: associations with relapse severity and recovery. PLoS One. 2013; 8(10):e75416. PMID: 24130709; PMCID: PMC3793991.
    37. Tan IL, Mowry EM, Steele SU, Pardo CA, McArthur JC, Nath A, Venkatesan A. Brainstem encephalitis: etiologies, treatment, and predictors of outcome. J Neurol. 2013 Sep; 260(9):2312-9. PMID: 23749332.
      View in: PubMed
    38. Waubant E, Mowry EM, Krupp L, Chitnis T, Yeh EA, Kuntz N, Ness J, Belman A, Milazzo M, Gorman M, Weinstock-Guttman B, Rodriguez M, James JA. Antibody response to common viruses and human leukocyte antigen-DRB1 in pediatric multiple sclerosis. Mult Scler. 2013 Jun; 19(7):891-5. PMID: 23232601; PMCID: PMC3665694.
    39. von Geldern G, Mowry EM. The influence of nutritional factors on the prognosis of multiple sclerosis. Nat Rev Neurol. 2012 Dec; 8(12):678-89. PMID: 23026980.
      View in: PubMed
    40. Mowry EM, Waubant E, McCulloch CE, Okuda DT, Evangelista AA, Lincoln RR, Gourraud PA, Brenneman D, Owen MC, Qualley P, Bucci M, Hauser SL, Pelletier D. Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis. Ann Neurol. 2012 Aug; 72(2):234-40. PMID: 22926855; PMCID: PMC3430977.
    41. Fay AJ, Mowry EM, Strober J, Waubant E. Relapse severity and recovery in early pediatric multiple sclerosis. Mult Scler. 2012 Jul; 18(7):1008-12. PMID: 22183939.
      View in: PubMed
    42. Mowry EM. Vitamin D: evidence for its role as a prognostic factor in multiple sclerosis. J Neurol Sci. 2011 Dec 15; 311(1-2):19-22. PMID: 21762931.
      View in: PubMed
    43. Mowry EM. Natural history of multiple sclerosis: early prognostic factors. Neurol Clin. 2011 May; 29(2):279-92. PMID: 21439441.
      View in: PubMed
    44. Castillo-Trivino T, Mowry EM, Gajofatto A, Chabas D, Crabtree-Hartman E, Cree BA, Goodin DS, Green AJ, Okuda DT, Pelletier D, Zamvil SS, Vittinghoff E, Waubant E. Switching multiple sclerosis patients with breakthrough disease to second-line therapy. PLoS One. 2011 Feb 03; 6(2):e16664. PMID: 21304907; PMCID: PMC3033401.
    45. Mowry EM, James JA, Krupp LB, Waubant E. Vitamin D status and antibody levels to common viruses in pediatric-onset multiple sclerosis. Mult Scler. 2011 Jun; 17(6):666-71. PMID: 21212086; PMCID: PMC3134182.
    46. Mowry EM, Waubant E. Pediatric multiple sclerosis. Continuum (Minneap Minn). 2010 Oct; 16(5 Multiple Sclerosis):181-92. PMID: 22810605.
      View in: PubMed
    47. Mowry EM, Julian LJ, Im-Wang S, Chabas D, Galvin AJ, Strober JB, Waubant E. Health-related quality of life is reduced in pediatric multiple sclerosis. Pediatr Neurol. 2010 Aug; 43(2):97-102. PMID: 20610119.
      View in: PubMed
    48. Mowry EM, Krupp LB, Milazzo M, Chabas D, Strober JB, Belman AL, McDonald JC, Oksenberg JR, Bacchetti P, Waubant E. Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis. Ann Neurol. 2010 May; 67(5):618-24. PMID: 20437559.
      View in: PubMed
    49. Kranick SM, Mowry EM, Colcher A, Horn S, Golbe LI. Movement disorders and pregnancy: a review of the literature. Mov Disord. 2010 Apr 30; 25(6):665-71. PMID: 20437535.
      View in: PubMed
    50. Waubant E, Chabas D, Okuda DT, Glenn O, Mowry E, Henry RG, Strober JB, Soares B, Wintermark M, Pelletier D. Difference in disease burden and activity in pediatric patients on brain magnetic resonance imaging at time of multiple sclerosis onset vs adults. Arch Neurol. 2009 Aug; 66(8):967-71. PMID: 19667217.
      View in: PubMed
    51. Mowry EM, Beheshtian A, Waubant E, Goodin DS, Cree BA, Qualley P, Lincoln R, George MF, Gomez R, Hauser SL, Okuda DT, Pelletier D. Quality of life in multiple sclerosis is associated with lesion burden and brain volume measures. Neurology. 2009 May 19; 72(20):1760-5. PMID: 19451531; PMCID: PMC2683738.
    52. Mowry EM, Pesic M, Grimes B, Deen SR, Bacchetti P, Waubant E. Clinical predictors of early second event in patients with clinically isolated syndrome. J Neurol. 2009 Jul; 256(7):1061-6. PMID: 19252775; PMCID: PMC2708331.
    53. Mowry EM, Pesic M, Grimes B, Deen S, Bacchetti P, Waubant E. Demyelinating events in early multiple sclerosis have inherent severity and recovery. Neurology. 2009 Feb 17; 72(7):602-8. PMID: 19221292; PMCID: PMC2677540.
    54. Mowry EM, Deen S, Malikova I, Pelletier J, Bacchetti P, Waubant E. The onset location of multiple sclerosis predicts the location of subsequent relapses. J Neurol Neurosurg Psychiatry. 2009 Apr; 80(4):400-3. PMID: 19066192.
      View in: PubMed
    55. Kranick SM, Mowry EM, Rosenfeld MR. Progressive multifocal leukoencephalopathy after rituximab in a case of non-Hodgkin lymphoma. Neurology. 2007 Aug 14; 69(7):704-6. PMID: 17698796.
      View in: PubMed
    56. Mowry EM, Woo JH, Ances BM. Baló's concentric sclerosis presenting as a stroke-like syndrome. Nat Clin Pract Neurol. 2007 Jun; 3(6):349-54. PMID: 17549061.
      View in: PubMed
    57. Mowry EM, Woo JH, Ances BM. Technology insight: can neuroimaging provide insights into the role of ischemia in Baló's concentric sclerosis? Nat Clin Pract Neurol. 2007 Jun; 3(6):341-8. PMID: 17549060.
      View in: PubMed
    58. Mowry EM, Balcer LJ, Galetta SL. Multiple sclerosis and the ophthalmologist. Compr Ophthalmol Update. 2007 Jan-Feb; 8(1):39-49. PMID: 17394758.
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