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Emil Lin, PhD

TitleProfessor Emeritus
InstitutionUniversity of California San Francisco
DepartmentBioengineering
Address513 Parnassus Ave, Med Sci
San Francisco CA 94143
Phone415-476-5035
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    Collapse Research 
    Collapse Research Activities and Funding
    NON-CLINICAL ADME STUDIES
    NIH N01DA48842May 3, 2004 - May 2, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Vanek VW, Ayers P, Kraft M, Bouche JM, Do VT, Durham CW, Guenter P, Hoggle L, Kent S, Lin ET, Molinar LS, Plogsted SW, Poehls JM, Turner P, Van Way C. A Call to Action for Optimizing the Electronic Health Record in the Parenteral Nutrition Workflow: Executive Summary. Nutr Clin Pract. 2018 Oct; 33(5):594-596. PMID: 30208264.
      View in: PubMed
    2. Vanek VW, Ayers P, Kraft M, Bouche JM, Do VT, Durham CW, Guenter P, Hoggle L, Kent S, Lin ET, Molinar LS, Plogsted SW, Poehls JM, Turner P, Van Way C. A Call to Action for Optimizing the Electronic Health Record in the Parenteral Nutrition Workflow. J Acad Nutr Diet. 2018 Aug; 118(8):1506-1525. PMID: 30055713.
      View in: PubMed
    3. Vanek VW, Ayers P, Kraft M, Bouche JM, Do VT, Durham CW, Guenter P, Hoggle L, Kent S, Lin ET, Molinar LS, Plogsted SW, Poehls JM, Turner P, Van Way C. A call to action for optimizing the electronic health record in the parenteral nutrition workflow. Am J Health Syst Pharm. 2018 Jul 31. PMID: 30065062.
      View in: PubMed
    4. Vanek VW, Ayers P, Kraft M, Bouche JM, Do VT, Durham CW, Guenter P, Hoggle L, Kent S, Lin ET, Molinar LS, Plogsted SW, Poehls JM, Turner P, Van Way C. A Call to Action for Optimizing the Electronic Health Record in the Parenteral Nutrition Workflow. Nutr Clin Pract. 2018 Jul 25. PMID: 30043492.
      View in: PubMed
    5. Caridi CP, D'Agostino C, Ryu T, Zapotoczny G, Delabaere L, Li X, Khodaverdian VY, Amaral N, Lin E, Rau AR, Chiolo I. Nuclear F-actin and myosins drive relocalization of heterochromatic breaks. Nature. 2018 Jun 20. PMID: 29925946.
      View in: PubMed
    6. Huang Y, Yang Q, Yoon K, Lei Y, Shi R, Gee W, Lin ET, Greenblatt RM, Gandhi M. Microanalysis of the antiretroviral nevirapine in human hair from HIV-infected patients by liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem. 2011 Oct; 401(6):1923-33. PMID: 21847531; PMCID: PMC3477620.
    7. Harris DS, Everhart T, Jacob P, Lin E, Mendelson JE, Jones RT. A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion. BMC Clin Pharmacol. 2009 Aug 01; 9:13. PMID: 19646280; PMCID: PMC2731040.
    8. Li M, Huang Y, Ma AA, Lin E, Diamond MI. Y-27632 improves rotarod performance and reduces huntingtin levels in R6/2 mice. Neurobiol Dis. 2009 Dec; 36(3):413-20. PMID: 19591939.
      View in: PubMed
    9. Zhang X, Tellew JE, Luo Z, Moorjani M, Lin E, Lanier MC, Chen Y, Williams JP, Saunders J, Lechner SM, Markison S, Joswig T, Petroski R, Piercey J, Kargo W, Malany S, Santos M, Gross RS, Wen J, Jalali K, O'Brien Z, Stotz CE, Crespo MI, Díaz JL, Slee DH. Lead optimization of 4-acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A adenosine receptor antagonists for the treatment of Parkinson's disease. J Med Chem. 2008 Nov 27; 51(22):7099-110. PMID: 18947224.
      View in: PubMed
    10. Huang Y, Gandhi M, Greenblatt RM, Gee W, Lin ET, Messenkoff N. Sensitive analysis of anti-HIV drugs, efavirenz, lopinavir and ritonavir, in human hair by liquid chromatography coupled with tandem mass spectrometry. Rapid Commun Mass Spectrom. 2008 Nov; 22(21):3401-9. PMID: 18837069; PMCID: PMC2669487.
    11. Holodniy M, Penzak SR, Straight TM, Davey RT, Lee KK, Goetz MB, Raisch DW, Cunningham F, Lin ET, Olivo N, Deyton LR. Pharmacokinetics and tolerability of oseltamivir combined with probenecid. Antimicrob Agents Chemother. 2008 Sep; 52(9):3013-21. PMID: 18559644; PMCID: PMC2533494.
    12. Jegatheesan P, Ianus V, Buchh B, Yoon G, Chorne N, Ewig A, Lin E, Fields S, Moon-Grady A, Tacy T, Milstein J, Schreiber M, Padbury J, Clyman R. Increased indomethacin dosing for persistent patent ductus arteriosus in preterm infants: a multicenter, randomized, controlled trial. J Pediatr. 2008 Aug; 153(2):183-9. PMID: 18534218.
      View in: PubMed
    13. Zhang X, Rueter JK, Chen Y, Moorjani M, Lanier MC, Lin E, Gross RS, Tellew JE, Williams JP, Lechner SM, Markison S, Joswig T, Malany S, Santos M, Castro-Palomino JC, Crespo MI, Prat M, Gual S, Díaz JL, Saunders J, Slee DH. Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists. Bioorg Med Chem Lett. 2008 Mar 15; 18(6):1778-83. PMID: 18329269.
      View in: PubMed
    14. Slee DH, Zhang X, Moorjani M, Lin E, Lanier MC, Chen Y, Rueter JK, Lechner SM, Markison S, Malany S, Joswig T, Santos M, Gross RS, Williams JP, Castro-Palomino JC, Crespo MI, Prat M, Gual S, Díaz JL, Wen J, O'Brien Z, Saunders J. Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy. J Med Chem. 2008 Feb 14; 51(3):400-6. PMID: 18189346.
      View in: PubMed
    15. Chorne N, Jegatheesan P, Lin E, Shi R, Clyman RI. Risk factors for persistent ductus arteriosus patency during indomethacin treatment. J Pediatr. 2007 Dec; 151(6):629-34. PMID: 18035143.
      View in: PubMed
    16. Yang R, Wilcox DM, Haasch DL, Jung PM, Nguyen PT, Voorbach MJ, Doktor S, Brodjian S, Bush EN, Lin E, Jacobson PB, Collins CA, Landschulz KT, Trevillyan JM, Rondinone CM, Surowy TK. Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice. J Biol Chem. 2007 Aug 03; 282(31):22765-74. PMID: 17550900.
      View in: PubMed
    17. Ng VY, Huang Y, Reddy LM, Falck JR, Lin ET, Kroetz DL. Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha. Drug Metab Dispos. 2007 Jul; 35(7):1126-34. PMID: 17431031.
      View in: PubMed
    18. Huang Y, Okochi H, May BC, Legname G, Prusiner SB, Benet LZ, Guglielmo BJ, Lin ET. Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Drug Metab Dispos. 2006 Jul; 34(7):1136-44. PMID: 16581945.
      View in: PubMed
    19. Yu Z, Ng VY, Su P, Engler MM, Engler MB, Huang Y, Lin E, Kroetz DL. Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary gamma-linolenic acid. J Pharmacol Exp Ther. 2006 May; 317(2):732-8. PMID: 16421287.
      View in: PubMed
    20. Lee CZ, Yao JS, Huang Y, Zhai W, Liu W, Guglielmo BJ, Lin E, Yang GY, Young WL. Dose-response effect of tetracyclines on cerebral matrix metalloproteinase-9 after vascular endothelial growth factor hyperstimulation. J Cereb Blood Flow Metab. 2006 Sep; 26(9):1157-64. PMID: 16395286.
      View in: PubMed
    21. Huang Y, Sun H, Frassetto L, Benet LZ, Lin ET. Liquid chromatographic tandem mass spectrometric assay for the uremic toxin 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in human plasma. Rapid Commun Mass Spectrom. 2006; 20(10):1611-4. PMID: 16628600.
      View in: PubMed
    22. Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Fujita K, Castro R, Chen CW, Lin ET, Brett CM, Burchard EG, Ferrin TE, Huang CC, Leabman MK, Giacomini KM. Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenet Genomics. 2005 Apr; 15(4):201-9. PMID: 15864112.
      View in: PubMed
    23. Dowling TC, Arjomand M, Lin ET, Allen LV, McPherson ML. Relative bioavailability of ketoprofen 20% in a poloxamer-lecithin organogel. Am J Health Syst Pharm. 2004 Dec 01; 61(23):2541-4. PMID: 15595229.
      View in: PubMed
    24. Yung L, Huang Y, Lessard P, Legname G, Lin ET, Baldwin M, Prusiner SB, Ryou C, Guglielmo BJ. Pharmacokinetics of quinacrine in the treatment of prion disease. BMC Infect Dis. 2004 Nov 29; 4:53. PMID: 15569390; PMCID: PMC535929.
    25. Scanlan TS, Suchland KL, Hart ME, Chiellini G, Huang Y, Kruzich PJ, Frascarelli S, Crossley DA, Bunzow JR, Ronca-Testoni S, Lin ET, Hatton D, Zucchi R, Grandy DK. 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat Med. 2004 Jun; 10(6):638-42. PMID: 15146179.
      View in: PubMed
    26. Huang Y, Zurlinden E, Lin E, Li X, Tokumoto J, Golden J, Murr A, Engstrom J, Conte J. Liquid chromatographic-tandem mass spectrometric assay for the simultaneous determination of didanosine and stavudine in human plasma, bronchoalveolar lavage fluid, alveolar cells, peripheral blood mononuclear cells, seminal plasma, cerebrospinal fluid and tonsil tissue. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Jan 05; 799(1):51-61. PMID: 14659435.
      View in: PubMed
    27. Harris DS, Mendelson JE, Lin ET, Upton RA, Jones RT. Pharmacokinetics and subjective effects of sublingual buprenorphine, alone or in combination with naloxone: lack of dose proportionality. Clin Pharmacokinet. 2004; 43(5):329-40. PMID: 15080765.
      View in: PubMed
    28. Conte JE, Golden JA, Kipps JE, Lin ET, Zurlinden E. Effect of sex and AIDS status on the plasma and intrapulmonary pharmacokinetics of rifampicin. Clin Pharmacokinet. 2004; 43(6):395-404. PMID: 15086276.
      View in: PubMed
    29. Wang D, Raehal KM, Lin ET, Lowery JJ, Kieffer BL, Bilsky EJ, Sadée W. Basal signaling activity of mu opioid receptor in mouse brain: role in narcotic dependence. J Pharmacol Exp Ther. 2004 Feb; 308(2):512-20. PMID: 14600246.
      View in: PubMed
    30. Pauli-Magnus C, Feiner J, Brett C, Lin E, Kroetz DL. No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects. Clin Pharmacol Ther. 2003 Nov; 74(5):487-98. PMID: 14586389.
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    31. Ren Q, Conte JE, Zurlinden E, Lin ET. A high-performance liquid chromatographic-tandem mass spectrometric method for the determination of cethromycin (ABT-773) in human plasma, bronchoalveolar lavage fluid, and alveolar cells. J Chromatogr Sci. 2003 Oct; 41(9):494-9. PMID: 14596787.
      View in: PubMed
    32. Phan DD, Chin-Hong P, Lin ET, Anderle P, Sadee W, Guglielmo BJ. Intra- and interindividual variabilities of valacyclovir oral bioavailability and effect of coadministration of an hPEPT1 inhibitor. Antimicrob Agents Chemother. 2003 Jul; 47(7):2351-3. PMID: 12821497; PMCID: PMC161865.
    33. Conte JE, Lin E, Zhao Y, Zurlinden E. A high-pressure liquid chromatographic-tandem mass spectrometric method for the determination of ethambutol in human plasma, bronchoalveolar lavage fluid, and alveolar cells. J Chromatogr Sci. 2002 Feb; 40(2):113-8. PMID: 11881704.
      View in: PubMed