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Emil Lin, PhD

TitleProfessor Emeritus
SchoolUCSF School of Pharmacy
DepartmentBioengineering
Address513 Parnassus Ave, Med Sci
San Francisco CA 94143
Phone415-476-5035
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    Collapse Research 
    Collapse Research Activities and Funding
    NON-CLINICAL ADME STUDIES
    NIH N01DA48842May 3, 2004 - May 2, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Huang Y, Yang Q, Yoon K, Lei Y, Shi R, Gee W, Lin E, Greenblatt RM, Gandhi M. Microanalysis of the antiretroviral nevirapine in human hair from HIV-infected patients by liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem. 2011 Oct; 401(6):1923-33. PMID: 21847531; PMCID: PMC3477620.
    2. Li M, Huang Y, Ma AA, Lin E, Diamond MI. Y-27632 improves rotarod performance and reduces huntingtin levels in R6/2 mice. Neurobiol Dis. 2009 Dec; 36(3):413-20. PMID: 19591939.
      View in: PubMed
    3. Zhang X, Tellew JE, Luo Z, Moorjani M, Lin E, Lanier MC, Chen Y, Williams JP, Saunders J, Lechner SM, Markison S, Joswig T, Petroski R, Piercey J, Kargo W, Malany S, Santos M, Gross RS, Wen J, Jalali K, O'Brien Z, Stotz CE, Crespo MI, Díaz JL, Slee DH. Lead optimization of 4-acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A adenosine receptor antagonists for the treatment of Parkinson's disease. J Med Chem. 2008 Nov 27; 51(22):7099-110. PMID: 18947224.
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    4. Huang Y, Gandhi M, Greenblatt RM, Gee W, Lin E, Messenkoff N. Sensitive analysis of anti-HIV drugs, efavirenz, lopinavir and ritonavir, in human hair by liquid chromatography coupled with tandem mass spectrometry. Rapid Commun Mass Spectrom. 2008 Nov; 22(21):3401-9. PMID: 18837069; PMCID: PMC2669487.
    5. Holodniy M, Penzak SR, Straight TM, Davey RT, Lee KK, Goetz MB, Raisch DW, Cunningham F, Lin E, Olivo N, Deyton LR. Pharmacokinetics and tolerability of oseltamivir combined with probenecid. Antimicrob Agents Chemother. 2008 Sep; 52(9):3013-21. PMID: 18559644; PMCID: PMC2533494.
    6. Jegatheesan P, Ianus V, Buchh B, Yoon G, Chorne N, Ewig A, Lin E, Fields S, Moon-Grady A, Tacy T, Milstein J, Schreiber M, Padbury J, Clyman R. Increased indomethacin dosing for persistent patent ductus arteriosus in preterm infants: a multicenter, randomized, controlled trial. J Pediatr. 2008 Aug; 153(2):183-9. PMID: 18534218.
      View in: PubMed
    7. Zhang X, Rueter JK, Chen Y, Moorjani M, Lanier MC, Lin E, Gross RS, Tellew JE, Williams JP, Lechner SM, Markison S, Joswig T, Malany S, Santos M, Castro-Palomino JC, Crespo MI, Prat M, Gual S, Díaz JL, Saunders J, Slee DH. Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists. Bioorg Med Chem Lett. 2008 Mar 15; 18(6):1778-83. PMID: 18329269.
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    8. Slee DH, Zhang X, Moorjani M, Lin E, Lanier MC, Chen Y, Rueter JK, Lechner SM, Markison S, Malany S, Joswig T, Santos M, Gross RS, Williams JP, Castro-Palomino JC, Crespo MI, Prat M, Gual S, Díaz JL, Wen J, O'Brien Z, Saunders J. Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy. J Med Chem. 2008 Feb 14; 51(3):400-6. PMID: 18189346.
      View in: PubMed
    9. Chorne N, Jegatheesan P, Lin E, Shi R, Clyman RI. Risk factors for persistent ductus arteriosus patency during indomethacin treatment. J Pediatr. 2007 Dec; 151(6):629-34. PMID: 18035143.
      View in: PubMed
    10. Shu Y, Brown C, Castro RA, Shi RJ, Lin E, Owen RP, Sheardown SA, Yue L, Burchard EG, Brett CM, Giacomini KM. Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics. Clin Pharmacol Ther. 2008 Feb; 83(2):273-80. PMID: 17609683; PMCID: PMC2976713.
    11. Yang R, Wilcox DM, Haasch DL, Jung PM, Nguyen PT, Voorbach MJ, Doktor S, Brodjian S, Bush EN, Lin E, Jacobson PB, Collins CA, Landschulz KT, Trevillyan JM, Rondinone CM, Surowy TK. Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice. J Biol Chem. 2007 Aug 03; 282(31):22765-74. PMID: 17550900.
      View in: PubMed
    12. Ng VY, Huang Y, Reddy LM, Falck JR, Lin E, Kroetz DL. Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha. Drug Metab Dispos. 2007 Jul; 35(7):1126-34. PMID: 17431031.
      View in: PubMed
    13. Huang Y, Okochi H, May BC, Legname G, Prusiner SB, Benet LZ, Guglielmo BJ, Lin E. Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Drug Metab Dispos. 2006 Jul; 34(7):1136-44. PMID: 16581945.
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    14. Yu Z, Ng VY, Su P, Engler MM, Engler MB, Huang Y, Lin E, Kroetz DL. Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary gamma-linolenic acid. J Pharmacol Exp Ther. 2006 May; 317(2):732-8. PMID: 16421287.
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    15. Lee CZ, Yao JS, Huang Y, Zhai W, Liu W, Guglielmo BJ, Lin E, Yang GY, Young WL. Dose-response effect of tetracyclines on cerebral matrix metalloproteinase-9 after vascular endothelial growth factor hyperstimulation. J Cereb Blood Flow Metab. 2006 Sep; 26(9):1157-64. PMID: 16395286.
      View in: PubMed
    16. Huang Y, Sun H, Frassetto L, Benet LZ, Lin E. Liquid chromatographic tandem mass spectrometric assay for the uremic toxin 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in human plasma. Rapid Commun Mass Spectrom. 2006; 20(10):1611-4. PMID: 16628600.
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    17. Tong CT, Howard SA, Shah HR, Van Quill KR, Lin E, Grossniklaus HE, O'Brien JM. Effects of celecoxib in human retinoblastoma cell lines and in a transgenic murine model of retinoblastoma. Br J Ophthalmol. 2005 Sep; 89(9):1217-20. PMID: 16113385; PMCID: PMC1772840.
    18. Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Fujita K, Castro R, Chen CW, Lin E, Brett CM, Burchard EG, Ferrin TE, Huang CC, Leabman MK, Giacomini KM. Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenet Genomics. 2005 Apr; 15(4):201-9. PMID: 15864112.
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    19. Dowling TC, Arjomand M, Lin E, Allen LV, McPherson ML. Relative bioavailability of ketoprofen 20% in a poloxamer-lecithin organogel. Am J Health Syst Pharm. 2004 Dec 01; 61(23):2541-4. PMID: 15595229.
      View in: PubMed
    20. Yung L, Huang Y, Lessard P, Legname G, Lin E, Baldwin M, Prusiner SB, Ryou C, Guglielmo BJ. Pharmacokinetics of quinacrine in the treatment of prion disease. BMC Infect Dis. 2004 Nov 29; 4:53. PMID: 15569390; PMCID: PMC535929.
    21. Scanlan TS, Suchland KL, Hart ME, Chiellini G, Huang Y, Kruzich PJ, Frascarelli S, Crossley DA, Bunzow JR, Ronca-Testoni S, Lin E, Hatton D, Zucchi R, Grandy DK. 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat Med. 2004 Jun; 10(6):638-42. PMID: 15146179.
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    22. Huang Y, Zurlinden E, Lin E, Li X, Tokumoto J, Golden J, Murr A, Engstrom J, Conte J. Liquid chromatographic-tandem mass spectrometric assay for the simultaneous determination of didanosine and stavudine in human plasma, bronchoalveolar lavage fluid, alveolar cells, peripheral blood mononuclear cells, seminal plasma, cerebrospinal fluid and tonsil tissue. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Jan 05; 799(1):51-61. PMID: 14659435.
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    23. Harris DS, Mendelson JE, Lin E, Upton RA, Jones RT. Pharmacokinetics and subjective effects of sublingual buprenorphine, alone or in combination with naloxone: lack of dose proportionality. Clin Pharmacokinet. 2004; 43(5):329-40. PMID: 15080765.
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    24. Conte JE, Golden JA, Kipps JE, Lin E, Zurlinden E. Effect of sex and AIDS status on the plasma and intrapulmonary pharmacokinetics of rifampicin. Clin Pharmacokinet. 2004; 43(6):395-404. PMID: 15086276.
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    25. Wang D, Raehal KM, Lin E, Lowery JJ, Kieffer BL, Bilsky EJ, Sadée W. Basal signaling activity of mu opioid receptor in mouse brain: role in narcotic dependence. J Pharmacol Exp Ther. 2004 Feb; 308(2):512-20. PMID: 14600246.
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    26. Pauli-Magnus C, Feiner J, Brett C, Lin E, Kroetz DL. No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects. Clin Pharmacol Ther. 2003 Nov; 74(5):487-98. PMID: 14586389.
      View in: PubMed
    27. Ren Q, Conte JE, Zurlinden E, Lin E. A high-performance liquid chromatographic-tandem mass spectrometric method for the determination of cethromycin (ABT-773) in human plasma, bronchoalveolar lavage fluid, and alveolar cells. J Chromatogr Sci. 2003 Oct; 41(9):494-9. PMID: 14596787.
      View in: PubMed
    28. Phan DD, Chin-Hong P, Lin E, Anderle P, Sadee W, Guglielmo BJ. Intra- and interindividual variabilities of valacyclovir oral bioavailability and effect of coadministration of an hPEPT1 inhibitor. Antimicrob Agents Chemother. 2003 Jul; 47(7):2351-3. PMID: 12821497; PMCID: PMC161865.
    29. Conte JE, Lin E, Zhao Y, Zurlinden E. A high-pressure liquid chromatographic-tandem mass spectrometric method for the determination of ethambutol in human plasma, bronchoalveolar lavage fluid, and alveolar cells. J Chromatogr Sci. 2002 Feb; 40(2):113-8. PMID: 11881704.
      View in: PubMed
    30. Conte JE, Golden JA, Kipps J, Lin E, Zurlinden E. Effects of AIDS and gender on steady-state plasma and intrapulmonary ethambutol concentrations. Antimicrob Agents Chemother. 2001 Oct; 45(10):2891-6. PMID: 11557486; PMCID: PMC90748.
    31. Conte JE, Wang G, Lin E, Zurlinden E. High-performance liquid chromatographic-tandem mass spectrometric method for the determination of ethionamide in human plasma, bronchoalveolar lavage fluid and alveolar cells. J Chromatogr B Biomed Sci Appl. 2001 Apr 05; 753(2):343-53. PMID: 11334350.
      View in: PubMed
    32. Conte JE, Golden JA, McQuitty M, Kipps J, Lin E, Zurlinden E. Effects of AIDS and gender on steady-state plasma and intrapulmonary ethionamide concentrations. Antimicrob Agents Chemother. 2000 May; 44(5):1337-41. PMID: 10770772; PMCID: PMC89865.
    33. Conte JE, Golden JA, McQuitty M, Kipps J, Lin E, Zurlinden E. Single-dose intrapulmonary pharmacokinetics of rifapentine in normal subjects. Antimicrob Agents Chemother. 2000 Apr; 44(4):985-90. PMID: 10722501; PMCID: PMC89802.
    34. Mizuma T, McDonagh AF, Lin E, Benet LZ. Photoinduced covalent binding of frusemide and frusemide glucuronide to human serum albumin. Br J Clin Pharmacol. 1999 Jul; 48(1):79-87. PMID: 10383564; PMCID: PMC2014883.
    35. Mizuma T, Benet LZ, Lin E. Interaction of human serum albumin with furosemide glucuronide: a role of albumin in isomerization, hydrolysis, reversible binding and irreversible binding of a 1-O-acyl glucuronide metabolite. Biopharm Drug Dispos. 1999 Apr; 20(3):131-6. PMID: 10211865.
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    36. Yu LL, Chao CK, Liao WJ, Twu TY, Liu CM, Yang TH, Lin E. Determination of clindamycin in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to the bioequivalence study of clindamycin. J Chromatogr B Biomed Sci Appl. 1999 Mar 19; 724(2):287-94. PMID: 10219670.
      View in: PubMed
    37. Zhang Y, Guo X, Lin E, Benet LZ. In vitro biotransformation of a novel antimalarial cysteine protease inhibitor in human liver microsomes. Pharmacology. 1999 Mar; 58(3):147-59. PMID: 9925971.
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    38. Mizuma T, Benet LZ, Lin E. High-performance liquid chromatographic determination and identification of acyl migration and photodegradation products of furosemide 1-O-acyl glucuronide. J Chromatogr B Biomed Sci Appl. 1998 Oct 23; 718(1):153-62. PMID: 9832372.
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    39. Zhang Y, Hsieh Y, Izumi T, Lin E, Benet LZ. Effects of ketoconazole on the intestinal metabolism, transport and oral bioavailability of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor and a P450 3A, P-glycoprotein dual substrate, in male Sprague-Dawley rats. J Pharmacol Exp Ther. 1998 Oct; 287(1):246-52. PMID: 9765344.
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    40. Zhang Y, Guo X, Lin E, Benet LZ. Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor. Drug Metab Dispos. 1998 Apr; 26(4):360-6. PMID: 9531525.
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    41. Mizuma T, Benet LZ, Lin E. Preparative chromatography of furosemide 1-O-acyl-glucuronide from urine using micronized amberiite XAD-2 and its application to other 1-O-acyl-glucuronides. Prep Biochem Biotechnol. 1998 Feb; 28(1):37-47. PMID: 9516641.
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    42. Liu CM, Chen YK, Yang TH, Hsieh SY, Hung MH, Lin E. High-performance liquid chromatographic determination of clindamycin in human plasma or serum: application to the bioequivalency study of clindamycin phosphate injections. J Chromatogr B Biomed Sci Appl. 1997 Aug 29; 696(2):298-302. PMID: 9323551.
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    43. Wu ST, Benet LZ, Lin E. Determination of amiprilose in human plasma by high-performance liquid chromatography with fluorimetric detection. J Chromatogr B Biomed Sci Appl. 1997 Apr 25; 692(1):149-56. PMID: 9187394.
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    44. Wu ST, Chang YP, Gee WL, Benet LZ, Lin E. Stereoselective high-performance liquid chromatography determination of propranolol and 4-hydroxypropranolol in human plasma after pre-column derivatization. J Chromatogr B Biomed Sci Appl. 1997 Apr 25; 692(1):133-40. PMID: 9187392.
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    45. Sambol NC, Chiang J, O'Conner M, Liu CY, Lin E, Goodman AM, Benet LZ, Karam JH. Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus. J Clin Pharmacol. 1996 Nov; 36(11):1012-21. PMID: 8973990.
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    46. Sambol NC, Brookes LG, Chiang J, Goodman AM, Lin E, Liu CY, Benet LZ. Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man. Br J Clin Pharmacol. 1996 Oct; 42(4):510-2. PMID: 8904626.
      View in: PubMed
    47. Sambol NC, Chiang J, Lin E, Goodman AM, Liu CY, Benet LZ, Cogan MG. Kidney function and age are both predictors of pharmacokinetics of metformin. J Clin Pharmacol. 1995 Nov; 35(11):1094-102. PMID: 8626883.
      View in: PubMed
    48. Lai ML, Wang SL, Lai MD, Lin E, Tse M, Huang JD. Propranolol disposition in Chinese subjects of different CYP2D6 genotypes. Clin Pharmacol Ther. 1995 Sep; 58(3):264-8. PMID: 7554699.
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    49. Sekikawa H, Yagi N, Oda K, Kenmotsu H, Takada M, Chen HF, Lin E, Benet LZ. Biliary excretion of furosemide glucuronide in rabbits. Biol Pharm Bull. 1995 Mar; 18(3):447-53. PMID: 7550101.
      View in: PubMed
    50. La Follette G, Jayewardene AL, Seneviratne AK, Lin E, Gambertoglio JG. Determination of ticarcillin in human plasma and in urine by reversed-phase LC. J Pharm Biomed Anal. 1995 Feb; 13(2):159-64. PMID: 7766723.
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    51. Sekikawa H, Yagi N, Lin E, Benet LZ. Apparent intramolecular acyl migration and hydrolysis of furosemide glucuronide in aqueous solution. Biol Pharm Bull. 1995 Jan; 18(1):134-9. PMID: 7735228.
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    52. Iwaki M, Ogiso T, Hayashi H, Lin E, Benet LZ. Simultaneous measurement of nicotinic acid and its major metabolite, nicotinuric acid in urine using high-performance liquid chromatography: application of solid-liquid extraction. J Chromatogr B Biomed Appl. 1994 Nov 04; 661(1):154-8. PMID: 7866544.
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    53. Han C, Jung P, Sanders SW, Lin E, Benet LZ. Pharmacokinetics of nitroglycerin and its four metabolites during nitroglycerin transdermal administration. Biopharm Drug Dispos. 1994 Mar; 15(2):179-83. PMID: 8011969.
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    54. Benet LZ, Spahn-Langguth H, Iwakawa S, Volland C, Mizuma T, Mayer S, Mutschler E, Lin E. Predictability of the covalent binding of acidic drugs in man. Life Sci. 1993; 53(8):PL141-6. PMID: 8350674.
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    55. Iwakawa S, Spahn H, Benet LZ, Lin E. Stereoselective disposition of carprofen, flunoxaprofen, and naproxen in rats. Drug Metab Dispos. 1991 Sep-Oct; 19(5):853-7. PMID: 1686227.
      View in: PubMed
    56. Williams RL, Thakker KM, John V, Lin E, Liang-Gee W, Benet LZ. Nitroglycerin absorption from transdermal systems: formulation effects and metabolite concentrations. Pharm Res. 1991 Jun; 8(6):744-9. PMID: 1905809.
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    57. Iwakawa S, He XW, Hashimoto S, Volland C, Benet LZ, Lin E. Stereoselective disposition of ketoprofen in rats. Drug Metab Dispos. 1991 May-Jun; 19(3):717-8. PMID: 1680643.
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    58. Williams RL, Upton RA, Ball L, Braun RL, Lin E, Liang-Gee W, Leeson LJ. Development of a new controlled-release formulation of chlorpheniramine maleate using in vitro/in vivo correlations. J Pharm Sci. 1991 Jan; 80(1):22-5. PMID: 2013843.
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    59. Rezvani A, Hwang F, Song ZH, Lin E, Way EL. Supersensitivity to electrical stimulation for assessing physical dependence on opioids in isolated tissues. J Pharmacol Exp Ther. 1990 Jul; 254(1):52-7. PMID: 2366190.
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    60. Nakashima E, Rigod JF, Lin E, Benet LZ. Pharmacokinetics of nitroglycerin and its dinitrate metabolites over a thirtyfold range of oral doses. Clin Pharmacol Ther. 1990 May; 47(5):592-8. PMID: 2111749.
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    61. Williams RL, Lin E, Liang-Gee W, Blume CD, Benet LZ. Absorption and disposition of a new low-dose combination formulation of hydrochlorothiazide and triamterene. Biopharm Drug Dispos. 1990 Apr; 11(3):233-43. PMID: 2328310.
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    62. Iwakawa S, Spahn H, Benet LZ, Lin E. Stereoselective binding of the glucuronide conjugates of carprofen enantiomers to human serum albumin. Biochem Pharmacol. 1990 Mar 01; 39(5):949-53. PMID: 2310420.
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    63. Iwakawa S, Suganuma T, Lee SF, Spahn H, Benet LZ, Lin E. Direct determination of diastereomeric carprofen glucuronides in human plasma and urine and preliminary measurements of stereoselective metabolic and renal elimination after oral administration of carprofen in man. Drug Metab Dispos. 1989 Jul-Aug; 17(4):414-9. PMID: 2571482.
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    64. Spahn H, Iwakawa S, Lin E, Benet LZ. Procedures to characterize in vivo and in vitro enantioselective glucuronidation properly: studies with benoxaprofen glucuronides. Pharm Res. 1989 Feb; 6(2):125-32. PMID: 2762212.
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    65. Sambol NC, Upton RA, Chremos AN, Lin E, Williams RL. A comparison of the influence of famotidine and cimetidine on phenytoin elimination and hepatic blood flow. Br J Clin Pharmacol. 1989 Jan; 27(1):83-7. PMID: 2565119; PMCID: PMC1379708.
    66. Yu DK, Williams RL, Benet LZ, Lin E, Giesing DH. Pharmacokinetics of nitroglycerin and metabolites in humans following oral dosing. Biopharm Drug Dispos. 1988 Nov-Dec; 9(6):557-65. PMID: 3147725.
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    67. La Follette G, Gambertoglio J, White JA, Knuth DW, Lin E. Determination of clindamycin in plasma or serum by high-performance liquid chromatography with ultraviolet detection. J Chromatogr. 1988 Oct 14; 431(2):379-88. PMID: 3243792.
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    68. Gawienowski M, Benet LZ, Fleckenstein L, Lin E. Ion-paired liquid chromatographic method for the analysis of blood and plasma for the antimalarial drug halofantrine and its putative mono-debutylated metabolite. J Chromatogr. 1988 Sep 09; 430(2):412-9. PMID: 3235515.
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    69. Schwartz JB, Upton RA, Lin E, Williams RL, Benet LZ. Effect of cimetidine or ranitidine administration on nifedipine pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther. 1988 Jun; 43(6):673-80. PMID: 3378388.
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    70. Conte JE, Upton RA, Lin E. Pentamidine pharmacokinetics in patients with AIDS with impaired renal function. J Infect Dis. 1987 Dec; 156(6):885-90. PMID: 3680992.
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    71. Williams RL, Mordenti J, Upton RA, Lin E, Gee WL, Blume CD, Benet LZ. Effects of formulation and food on the absorption of hydrochlorothiazide and triamterene or amiloride from combination diuretic products. Pharm Res. 1987 Aug; 4(4):348-52. PMID: 3508542.
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    72. Conte JE, Upton RA, Phelps RT, Wofsy CB, Zurlinden E, Lin E. Use of a specific and sensitive assay to determine pentamidine pharmacokinetics in patients with AIDS. J Infect Dis. 1986 Dec; 154(6):923-9. PMID: 3491164.
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    73. Shi RJ, Benet LZ, Lin E. High-performance liquid chromatographic assay of basic amine drugs in plasma and urine using a silica gel column and an aqueous mobile phase. I. Amiloride. J Chromatogr. 1986 Apr 25; 377:399-404. PMID: 3711234.
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    74. Rhoads DL, Wei LX, Lin E, Rezvani A, Way EL. Opioids and rat erythrocyte deformability. NIDA Res Monogr. 1986; 75:121-4. PMID: 3123933.
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    75. Sörgel F, Hasegawa J, Lin E, Williams RL. Oral triamterene disposition. Clin Pharmacol Ther. 1985 Sep; 38(3):306-12. PMID: 4028626.
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    76. Upton RA, Williams RL, Lin E, Gee WL, Blume CD, Benet LZ. Absence of a significant pharmacokinetic interaction between hydrochlorothiazide and triamterene when coadministered. J Pharmacokinet Biopharm. 1984 Dec; 12(6):575-86. PMID: 6533293.
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    77. Blume CD, Williams RL, Upton RA, Lin E, Benet LZ. Bioequivalence study of a new tablet formulation of triamterene and hydrochlorothiazide. Am J Med. 1984 Nov 05; 77(5A):59-61. PMID: 6496560.
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    78. Sörgel F, Lin E, Hasegawa J, Benet LZ. Liquid chromatographic analysis of triamterene and its major metabolite, hydroxytriamterene sulfate, in blood, plasma, and urine. J Pharm Sci. 1984 Jun; 73(6):831-3. PMID: 6737274.
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    79. Gambertoglio JG, Barriere SL, Lin E, Conte JE. Amdinocillin pharmacokinetics. Simultaneous administration with cephalothin and cerebrospinal fluid penetration. Am J Med. 1983 Aug 29; 75(2A):54-9. PMID: 6311006.
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    80. Noonan IA, Gambertoglio JG, Barriere SL, Conte JE, Lin E. High-performance liquid chromatographic determination of cefmenoxime (AB-50912) in human plasma and urine. J Chromatogr. 1983 Apr 08; 273(2):458-63. PMID: 6306028.
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    81. Benet LZ, Smith DE, Lin E, Vincenti F, Gambertoglio JG. Furosemide assays and disposition in healthy volunteers and renal transplant patients. Fed Proc. 1983 Apr; 42(6):1695-8. PMID: 6339277.
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    82. Hasegawa J, Lin E, Williams RL, Sörgel F, Benet LZ. Pharmacokinetics of triamterene and its metabolite in man. J Pharmacokinet Biopharm. 1982 Oct; 10(5):507-23. PMID: 7166735.
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    83. Barriere SL, Hatheway GJ, Gambertoglio JG, Lin E, Conte JE. Pharmacokinetics of cefonicid, a new broad-spectrum cephalosporin. Antimicrob Agents Chemother. 1982 Jun; 21(6):935-8. PMID: 7114840; PMCID: PMC182048.
    84. Williams RL, Blume CD, Lin E, Holford NH, Benet LZ. Relative bioavailability of chlorthalidone in humans: adverse influence of polyethylene glycol. J Pharm Sci. 1982 May; 71(5):533-5. PMID: 7097499.
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    85. Williams RL, Davies RO, Berman RS, Holmes GI, Huber P, Gee WL, Lin E, Benet LZ. Hydrochlorothiazide pharmacokinetics and pharmacologic effect: the influence of indomethacin. J Clin Pharmacol. 1982 Jan; 22(1):32-41. PMID: 7061724.
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    86. Barriere SL, Gambertoglio JG, Lin E, Conte JE. Multiple-dose pharmacokinetics of amdinocillin in healthy volunteers. Antimicrob Agents Chemother. 1982 Jan; 21(1):54-7. PMID: 6282208; PMCID: PMC181828.
    87. Gambertoglio JG, Barriere SL, Lin E, Conte JE. Pharmacokinetics of mecillinam in health subjects. Antimicrob Agents Chemother. 1980 Dec; 18(6):952-6. PMID: 6263180; PMCID: PMC352996.
    88. Brater DC, Kaojarern S, Benet LZ, Lin E, Lockwood T, Morris RC, McSherry EJ, Melmon KL. Renal excretion of pseudoephedrine. Clin Pharmacol Ther. 1980 Nov; 28(5):690-4. PMID: 7438686.
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    89. Lin E, Baughman RA, Benet LZ. High-performance liquid chromatographic determination of prazosin in human plasma, whole blood and urine. J Chromatogr. 1980 Sep 12; 183(3):367-71. PMID: 7419656.
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    90. Smith DE, Lin E, Benet LZ. Absorption and disposition of furosemide in healthy volunteers, measured with a metabolite-specific assay. Drug Metab Dispos. 1980 Sep-Oct; 8(5):337-42. PMID: 6107232.
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    91. Baughman RA, Arnold S, Benet LZ, Lin E, Chatterjee K, Williams RL. Altered prazosin pharmacokinetics in congestive heart failure. Eur J Clin Pharmacol. 1980 Jun; 17(6):425-8. PMID: 7398734.
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    92. Smith DE, Gee WL, Brater DC, Lin E, Benet LZ. Preliminary evaluation of furosemide-probenecid interaction in humans. J Pharm Sci. 1980 May; 69(5):571-5. PMID: 7381747.
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    93. Gambertoglio JG, Aziz NS, Lin E, Grausz H, Naughton JL, Benet LZ. Cefamandole kinetics in uremic patients undergoing hemodialysis. Clin Pharmacol Ther. 1979 Nov; 26(5):592-9. PMID: 498702.
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    94. Lin E, Smith DE, Benet LZ, Hoener BA. High-performance liquid chromatographic assays for furosemide in plasma and urine. J Chromatogr. 1979 Jul 21; 163(3):315-21. PMID: 541387.
      View in: PubMed
    95. Smith DE, Brater DC, Lin E, Benet LZ. Attenuation of furosemide's diuretic effect by indomethacin: pharmacokinetic evaluation. J Pharmacokinet Biopharm. 1979 Jun; 7(3):265-74. PMID: 480148.
      View in: PubMed
    96. Aziz NS, Gambertoglio JG, Lin E, Grausz H, Benet LZ. Pharmacokinetics of cefamandole using a HPLC assay. J Pharmacokinet Biopharm. 1978 Apr; 6(2):153-64. PMID: 671221.
      View in: PubMed
    97. Ding TL, Lin E, Benet LZ. The reversible biotransformation of N-acetylprocainamide in the rhesus monkey. Arzneimittelforschung. 1978; 28(2):281-3. PMID: 416831.
      View in: PubMed
    98. Lin E, Brater DC, Benet LZ. Gas-liquid chromatographic determination of pseudoephedrine and norpseudoephedrine in human plasma and urine. J Chromatogr. 1977 Oct 21; 140(3):275-9. PMID: 914918.
      View in: PubMed
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