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Case Report: Novel Biallelic Variants in the COL18A1 Gene in a Chinese Family With Knobloch Syndrome. Front Neurol. 2022; 13:853918.
Chong SC, Yuen YP, Cao Y, Fan SS, Leung TY, Chan EKY, Zhu XL. PMID: 35693012; PMCID: PMC9178278.
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CUB domain containing protein 1 (CDCP1) is a target for radioligand therapy in castration resistant prostate cancer including PSMA null disease. Clin Cancer Res. 2022 May 23.
Zhao N, Chopra S, Trepka K, Wang YH, Sakhamuri S, Hooshdaran N, Kim H, Zhou J, Leung KK, Egusa EA, Zhu J, Zhang L, Foye A, Sriram R, Chan E, Seo Y, Feng FY, Small EJ, Chou J, Wells JA, Aggarwal R, Evans MJ. PMID: 35604681.
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An exploration in pitfalls in interpreting SDHB immunohistochemistry. Histopathology. 2022 May 11.
Ding CC, Chan S, Mak J, Umetsu SE, Simko JP, Ruiz-Cordero R, Saunders T, Chan E. PMID: 35546442.
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Real-World Study of Characteristics and Treatment Outcomes Among Patients with KRAS p.G12C-Mutated or Other KRAS Mutated Metastatic Colorectal Cancer. Oncologist. 2022 Apr 26.
Fakih M, Tu H, Hsu H, Aggarwal S, Chan E, Rehn M, Chia V, Kopetz S. PMID: 35472176.
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Granulomas associated with renal neoplasms: A multi-institutional clinicopathological study of 111 cases. Histopathology. 2022 May; 80(6):922-927.
Sangoi AR, Maclean F, Mohanty S, Hes O, Daniel R, Lal P, Canete-Portillo S, Magi-Galluzzi C, Cornejo KM, Collins K, Hwang M, Falzarano SM, Feely MM, Dababneh M, Harik L, Tretiakova M, Akgul M, Manucha V, Chan E, Kao CS, Siadat F, Arora K, Barkan G, Cheng L, Hirsch M, Lei L, Wasco M, Williamson SR, Acosta AM. PMID: 35347739.
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p53 null phenotype is a "positive result" in urothelial carcinoma in situ. Mod Pathol. 2022 Mar 23.
Sangoi AR, Chan E, Abdulfatah E, Stohr BA, Nguyen J, Trpkov K, Siadat F, Hirsch M, Falzarano S, Udager AM, Kunju LP. PMID: 35322193.
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APOBEC Mutational Signature and Tumor Mutational Burden as Predictors of Clinical Outcomes and Treatment Response in Patients With Advanced Urothelial Cancer. Front Oncol. 2022; 12:816706.
Natesan D, Zhang L, Martell HJ, Jindal T, Devine P, Stohr B, Espinosa-Mendez C, Grenert J, Van Ziffle J, Joseph N, Umetsu S, Onodera C, Turski M, Chan E, Desai A, Aggarwal R, Wong A, Porten S, Chou J, Friedlander T, Fong L, Small EJ, Sweet-Cordero A, Koshkin VS. PMID: 35321431; PMCID: PMC8935010.
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Papillary Renal Cell Carcinoma With Microcystic Architecture Is Strongly Associated With Extrarenal Invasion and Metastatic Disease. Am J Surg Pathol. 2022 03 01; 46(3):392-403.
Chan E, Stohr BA, Butler RS, Cox RM, Myles JL, Nguyen JK, Przybycin CG, Reynolds JP, Williamson SR, McKenney JK. PMID: 34881751.
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Gods and monsters: Greek mythology and Christian references in the neurosurgical lexicon. Surg Neurol Int. 2022; 13:67.
Woo PYM, Au D, Ko NMW, Wu O, Chan EKY, Cheng KKF, Wong AKS, Kirollos RW, Ribas G, Chan KY. PMID: 35242433; PMCID: PMC8888308.
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TROP2 Expression Across Molecular Subtypes of Urothelial Carcinoma and Enfortumab Vedotin-resistant Cells. Eur Urol Oncol. 2022 Feb 22.
Chou J, Trepka K, Sjöström M, Egusa EA, Chu CE, Zhu J, Chan E, Gibb EA, Badura ML, Contreras-Sanz A, Stohr BA, Meng MV, Pruthi RS, Lotan Y, Black PC, Porten SP, Koshkin VS, Friedlander TW, Feng FY. PMID: 35216942.
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Analysis of separate training and validation radical prostatectomy cohorts identifies 0.25 mm diameter as an optimal definition for "large" cribriform prostatic adenocarcinoma. Mod Pathol. 2022 Feb 10.
Chan E, McKenney JK, Hawley S, Corrigan D, Auman H, Newcomb LF, Boyer HD, Carroll PR, Cooperberg MR, Klein E, Fazli L, Gleave ME, Hurtado-Coll A, Simko JP, Nelson PS, Thompson IM, Tretiakova MS, Troyer D, True LD, Vakar-Lopez F, Lin DW, Brooks JD, Feng Z, Nguyen JK. PMID: 35145197.
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Expanding the clinicopathological spectrum of succinate dehydrogenase-deficient renal cell carcinoma with a focus on variant morphologies: a study of 62 new tumors in 59 patients. Mod Pathol. 2021 Dec 23.
Fuchs TL, Maclean F, Turchini J, Vargas AC, Bhattarai S, Agaimy A, Hartmann A, Kao CS, Ellis C, Bonert M, Leroy X, Kunju LP, Schwartz L, Matsika A, Williamson SR, Rao P, Divatia M, Guarch R, Algaba F, Balancin ML, Zhou M, Samaratunga H, da Cunha IW, Brimo F, Ryan A, Clouston D, Aron M, O'Donnell M, Chan E, Hirsch MS, Moch H, Pang CY, Wah C, Yin W, Perry-Keene J, Yilmaz A, Chou A, Clarkson A, van der Westhuizen G, Morrison E, Zwi J, Hes O, Trpkov K, Gill AJ. PMID: 34949766.
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Differential immunohistochemical and molecular profiling of conventional and aggressive components of chromophobe renal cell carcinoma: pitfalls for diagnosis. Hum Pathol. 2022 01; 119:85-93.
Chen CV, Croom NA, Simko JP, Stohr BA, Chan E. PMID: 34800526.
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TERT promoter mutations and other prognostic factors in patients with advanced urothelial carcinoma treated with an immune checkpoint inhibitor. J Immunother Cancer. 2021 05; 9(5).
de Kouchkovsky I, Zhang L, Philip EJ, Wright F, Kim DM, Natesan D, Kwon D, Ho H, Ho S, Chan E, Porten SP, Wong AC, Desai A, Huang FW, Chou J, Oh DY, Pruthi RS, Fong L, Small EJ, Friedlander TW, Koshkin VS. PMID: 33980590; PMCID: PMC8118032.
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Prostate biopsy histopathologic features correlate with a commercial gene expression assay's reclassification of patient NCCN risk category. Prostate. 2020 12; 80(16):1421-1428.
Greenland NY, Cowan JE, Chan E, Carroll PR, Stohr BA, Simko JP. PMID: 32946625.
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1 Fields:
Translation:
Humans
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Invasive poorly differentiated adenocarcinoma of the bladder following augmentation cystoplasty: a multi-institutional clinicopathological study. Pathology. 2021 Feb; 53(2):214-219.
Anderson JA, Matoso A, Murati Amador BI, Cheng L, Stohr BA, Chan E, Osunkoya AO. PMID: 32951908.
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Translation:
Humans
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The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma. Am J Surg Pathol. 2020 08; 44(8):e87-e99.
van Leenders GJLH, van der Kwast TH, Grignon DJ, Evans AJ, Kristiansen G, Kweldam CF, Litjens G, McKenney JK, Melamed J, Mottet N, Paner GP, Samaratunga H, Schoots IG, Simko JP, Tsuzuki T, Varma M, Warren AY, Wheeler TM, Williamson SR, Iczkowski KA, ISUP Grading Workshop Panel Members. PMID: 32459716; PMCID: PMC7382533.
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18 Fields:
Translation:
Humans
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Invasive plasmacytoid urothelial carcinoma: A comparative study of E-cadherin and P120 catenin. Hum Pathol. 2020 08; 102:54-59.
Sangoi AR, Chan E, Stohr BA, Kunju LP. PMID: 32673685.
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1 Fields:
Translation:
Humans
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Prevalence and associated factors for carriage of Enterobacteriaceae producing ESBLs or carbapenemase and methicillin-resistant Staphylococcus aureus in Hong Kong community. J Infect. 2020 08; 81(2):242-247.
Kwok KO, Chan E, Chung PH, Tang A, Wei WI, Zhu C, Riley S, Ip M. PMID: 32447008.
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Molecular characterisation of metanephric adenomas beyond BRAF: genetic evidence for potential malignant evolution. Histopathology. 2020 Jun; 76(7):1084-1090.
Chan E, Stohr BA, Croom NA, Cho SJ, Garg K, Troxell ML, Higgins JP, Bean GR. PMID: 32064677.
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3 Fields:
Translation:
Humans
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Integrated immunohistochemical and molecular analysis improves diagnosis of high-grade carcinoma in the urinary bladder of patients with prior radiation therapy for prostate cancer. Mod Pathol. 2020 09; 33(9):1802-1810.
Chan E, Garg K, Stohr BA. PMID: 32313185.
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1 Fields:
Translation:
Humans
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Expansile cribriform Gleason pattern 4 has histopathologic and molecular features of aggressiveness and greater risk of biochemical failure compared to glomerulation Gleason pattern 4. Prostate. 2020 05; 80(8):653-659.
Greenland NY, Cowan JE, Zhang L, Carroll PR, Chan E, Stohr BA, Simko JP. PMID: 32220141.
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2 Fields:
Translation:
Humans
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STAT6 monoclonal antibody is highly specific for the distinction between solitary fibrous tumour and prostatic stromal proliferations. Histopathology. 2020 03; 76(4):625-626.
Cox RM, Chan E, Sangoi AR, Zou Y, McKenney JK. PMID: 31498908.
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Translation:
Humans
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A Clinicopathologic and Molecular Analysis of Fumarate Hydratase-deficient Renal Cell Carcinoma in 32 Patients. Am J Surg Pathol. 2020 01; 44(1):98-110.
Lau HD, Chan E, Fan AC, Kunder CA, Williamson SR, Zhou M, Idrees MT, Maclean FM, Gill AJ, Kao CS. PMID: 31524643.
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8 Fields:
Translation:
Humans
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Detailed Morphologic and Immunohistochemical Characterization of Myomectomy and Hysterectomy Specimens From Women With Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome (HLRCC). Am J Surg Pathol. 2019 09; 43(9):1170-1179.
Chan E, Rabban JT, Mak J, Zaloudek C, Garg K. PMID: 31162287.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Beyond Depth of Invasion: Adverse Pathologic Tumor Features in Early Oral Tongue Squamous Cell Carcinoma. Laryngoscope. 2020 07; 130(7):1715-1720.
Larson AR, Kemmer J, Formeister E, El-Sayed I, Ha P, George J, Ryan W, Chan E, Heaton C. PMID: 31411752.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Prospective Detection of Germline Mutation of Fumarate Hydratase in Women With Uterine Smooth Muscle Tumors Using Pathology-based Screening to Trigger Genetic Counseling for Hereditary Leiomyomatosis Renal Cell Carcinoma Syndrome: A 5-Year Single Institutional Experience. Am J Surg Pathol. 2019 05; 43(5):639-655.
Rabban JT, Chan E, Mak J, Zaloudek C, Garg K. PMID: 30741757.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial. JAMA. 2019 04 09; 321(14):1370-1379.
Ng K, Nimeiri HS, McCleary NJ, Abrams TA, Yurgelun MB, Cleary JM, Rubinson DA, Schrag D, Miksad R, Bullock AJ, Allen J, Zuckerman D, Chan E, Chan JA, Wolpin BM, Constantine M, Weckstein DJ, Faggen MA, Thomas CA, Kournioti C, Yuan C, Ganser C, Wilkinson B, Mackintosh C, Zheng H, Hollis BW, Meyerhardt JA, Fuchs CS. PMID: 30964527; PMCID: PMC6459117.
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Phase I Study of AMG 337, a Highly Selective Small-molecule MET Inhibitor, in Patients with Advanced Solid Tumors. Clin Cancer Res. 2019 Apr 15; 25(8):2403-2413.
Hong DS, LoRusso P, Hamid O, Janku F, Kittaneh M, Catenacci DVT, Chan E, Bekaii-Saab T, Gadgeel SM, Loberg RD, Amore BM, Hwang YC, Tang R, Ngarmchamnanrith G, Kwak EL. PMID: 30425090; PMCID: PMC6892342.
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Improved diagnostic precision of urine cytology by implementation of The Paris System and the use of cell blocks. Cancer Cytopathol. 2018 09; 126(9):809-816.
Chan E, Balassanian R, Tabatabai ZL, Lou H, Vohra P. PMID: 30203925.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer. Cancer Res. 2017 10 15; 77(20):5564-5575.
Jin L, Garcia J, Chan E, de la Cruz C, Segal E, Merchant M, Kharbanda S, Raisner R, Haverty PM, Modrusan Z, Ly J, Choo E, Kaufman S, Beresini MH, Romero FA, Magnuson S, Gascoigne KE. PMID: 28819026.
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Angiocentric glioma with MYB-QKI fusion located in the brainstem, rather than cerebral cortex. Acta Neuropathol. 2017 Oct; 134(4):671-673.
Chan E, Bollen AW, Sirohi D, Van Ziffle J, Grenert JP, Kline CN, Tihan T, Perry A, Gupta N, Solomon DA. PMID: 28776091; PMCID: PMC5693679.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Value of histopathology for predicting the post-operative complications of ileo-anal anastomosis (J-pouch) procedure in children with refractory ulcerative colitis. Pathology. 2016 Jun; 48(4):330-5.
El Demellawy D, El Hallani S, de Nanassy J, Lee JY, Chan E, Sullivan K, Bass J, Mack D, Nasr A. PMID: 27130833.
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A phase I study of continuous oral dosing of OSI-906, a dual inhibitor of insulin-like growth factor-1 and insulin receptors, in patients with advanced solid tumors. Clin Cancer Res. 2015 Feb 15; 21(4):701-11.
Puzanov I, Lindsay CR, Goff L, Sosman J, Gilbert J, Berlin J, Poondru S, Simantov R, Gedrich R, Stephens A, Chan E, Evans TR. PMID: 25212606.
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Polarized exocyst-mediated vesicle fusion directs intracellular lumenogenesis within the C. elegans excretory cell. Dev Biol. 2014 Oct 01; 394(1):110-21.
Armenti ST, Chan E, Nance J. PMID: 25102190; PMCID: PMC4373406.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Mechanisms of CDC-42 activation during contact-induced cell polarization. J Cell Sci. 2013 Apr 01; 126(Pt 7):1692-702.
Chan E, Nance J. PMID: 23424200; PMCID: PMC3647442.
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PubMed Mentions:
19 Fields:
Translation:
Animals
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Safety, pharmacokinetics and pharmacodynamics of the anti-A33 fully-human monoclonal antibody, KRN330, in patients with advanced colorectal cancer. Eur J Cancer. 2013 Apr; 49(6):1169-75.
Infante JR, Bendell JC, Goff LW, Jones SF, Chan E, Sudo T, Burris HA, Berlin JD. PMID: 23294608.
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Safety and pharmacokinetics of ganitumab (AMG 479) combined with sorafenib, panitumumab, erlotinib, or gemcitabine in patients with advanced solid tumors. Clin Cancer Res. 2012 Jun 15; 18(12):3414-27.
Rosen LS, Puzanov I, Friberg G, Chan E, Hwang YC, Deng H, Gilbert J, Mahalingam D, McCaffery I, Michael SA, Mita AC, Mita MM, Mulay M, Shubhakar P, Zhu M, Sarantopoulos J. PMID: 22510349.
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PubMed Mentions:
14 Fields:
Translation:
HumansCTClinical Trials
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Anaerobic degradation of benzene, toluene, ethylbenzene, and xylene compounds by Dechloromonas strain RCB. Appl Environ Microbiol. 2005 Dec; 71(12):8649-55.
Chakraborty R, O'Connor SM, Chan E, Coates JD. PMID: 16332859; PMCID: PMC1317370.
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PubMed Mentions:
32 Fields:
Translation:
Cells