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Fanny Elahi, MD, PhD

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
Phone415-476-6880
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Overview 
    Collapse Overview
    Fanny Elahi is a board-certified neurologist with specific expertise in the evaluation and management of patients with cognitive and behavioral disorders due to degenerative brain diseases such as Alzheimer's disease and related disorders. She completed her bachelor's degree at Columbia University, her MD from Icahn School of Medicine, at Mount Sinai, and her DPhil from Oxford University. She pursued her residency in neurology at the University of California, Los Angeles and joined the University of California, San Francisco Memory and Aging Center in 2015 where she trained in neurodegenerative disorders prior to joining the faculty in the department of Neurology. Her research is focused on the identification of early biomarkers of degenerative brain disease with a particular interest in characterization of contributions of immune dysregulation and vascular disease to brain dysfunction, mood and cognitive changes, and ultimately progressive brain degeneration. Her work has been supported by the American Academy of Neurology in partnership with the Allergan foundation, the Alzheimer's Disease Research Center at the UCSF Memory and Aging Center, the National Institute of Neurological Disorders and Stroke, as well as philanthropic donations.

    Collapse Research 
    Collapse Research Activities and Funding
    Multi-cellular exosome-based biomarkers to capture the dysfunction of the neurovascular unit in early-preclinical stages of AD-related brain degeneration
    Donors Cure Foundation CCAD201903Jun 1, 2019 - May 31, 2021
    Role: Principal Investigator
    Immunomodulation to promote cerebrovascular and cognitive health
    AHA / Allen Frontiers Group Feb 1, 2019 - Jan 31, 2024
    Role: Co-Investigator
    Novel imaging and endothelial biomarkers of small vessel cerebrovascular disease
    NIH/NINDS UH3NS100608Sep 30, 2016 - Jun 30, 2021
    Role: Co-Investigator
    Effects of chronic inflammation on brain structure and function
    NIH/NIA R01AG048234Apr 15, 2015 - Jan 31, 2020
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Casaletto KB, Lindbergh C, Memel M, Staffaroni A, Elahi F, Weiner-Light S, You M, Fonseca C, Karydas A, Jacobs E, Dubal DB, Yaffe K, Kramer JH. Sexual dimorphism of physical activity on cognitive aging: Role of immune functioning. Brain Behav Immun. 2020 May 06. PMID: 32387511.
      View in: PubMed
    2. Abner EL, Elahi FM, Jicha GA, Mustapic M, Al-Janabi O, Kramer JH, Kapogiannis D, Goetzl EJ. Endothelial-derived plasma exosome proteins in Alzheimer's disease angiopathy. FASEB J. 2020 Mar 10. PMID: 32157747.
      View in: PubMed
    3. Baldacci F, Mazzucchi S, Della Vecchia A, Giampietri L, Giannini N, Koronyo-Hamaoui M, Ceravolo R, Siciliano G, Bonuccelli U, Elahi FM, Vergallo A, Lista S, Giorgi FS, Hampel H. The path to biomarker-based diagnostic criteria for the spectrum of neurodegenerative diseases. Expert Rev Mol Diagn. 2020 Apr; 20(4):421-441. PMID: 32066283.
      View in: PubMed
    4. Altendahl M, Maillard P, Harvey D, Cotter D, Walters S, Wolf A, Singh B, Kakarla V, Azizkhanian I, Sheth SA, Xiao G, Fox E, You M, Leng M, Elashoff D, Kramer JH, Decarli C, Elahi F, Hinman JD. An IL-18-centered inflammatory network as a biomarker for cerebral white matter injury. PLoS One. 2020; 15(1):e0227835. PMID: 31978079.
      View in: PubMed
    5. Elahi FM, Casaletto KB, La Joie R, Walters SM, Harvey D, Wolf A, Edwards L, Rivera-Contreras W, Karydas A, Cobigo Y, Rosen HJ, DeCarli C, Miller BL, Rabinovici GD, Kramer JH. Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's disease. Alzheimers Dement. 2020 04; 16(4):681-695. PMID: 31879236.
      View in: PubMed
    6. Gate D, Saligrama N, Leventhal O, Yang AC, Unger MS, Middeldorp J, Chen K, Lehallier B, Channappa D, De Los Santos MB, McBride A, Pluvinage J, Elahi F, Tam GK, Kim Y, Greicius M, Wagner AD, Aigner L, Galasko DR, Davis MM, Wyss-Coray T. Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease. Nature. 2020 01; 577(7790):399-404. PMID: 31915375.
      View in: PubMed
    7. Staffaroni AM, Bajorek L, Casaletto KB, Cobigo Y, Goh SM, Wolf A, Heuer HW, Elahi FM, Ljubenkov PA, Dever R, Kornak J, Appleby B, Bove J, Bordelon Y, Brannelly P, Brushaber D, Caso C, Coppola G, Dheel C, Dickerson BC, Dickinson S, Dominguez S, Domoto-Reilly K, Faber K, Ferrall J, Fields JA, Fishman A, Fong J, Foroud T, Forsberg LK, Gavrilova R, Gearhart D, Ghazanfari B, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grant I, Grossman M, Haley D, Hsiung GY, Huey ED, Irwin DJ, Jones DT, Jones L, Kantarci K, Karydas A, Kaufer DI, Kerwin DR, Knopman DS, Kraft R, Kremers WK, Kukull WA, Litvan I, Lucente D, Lungu C, Mackenzie IR, Maldonado M, Manoochehri M, McGinnis SM, McKinley E, Mendez MF, Miller BL, Multani N, Onyike C, Padmanabhan J, Pantelyat A, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin KP, Rascovsky K, Roberson ED, Rogalski E, Sengdy P, Shaw LM, Syrjanen J, Tartaglia MC, Tatton N, Taylor J, Toga A, Trojanowski JQ, Weintraub S, Wang P, Wong B, Wszolek Z, Boxer AL, Boeve BF, Kramer JH, Rosen HJ. Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint. Alzheimers Dement. 2020 01; 16(1):11-21. PMID: 31914230.
      View in: PubMed
    8. Casaletto KB, Staffaroni AM, Wolf A, Appleby B, Brushaber D, Coppola G, Dickerson B, Domoto-Reilly K, Elahi FM, Fields J, Fong JC, Forsberg L, Ghoshal N, Graff-Radford N, Grossman M, Heuer HW, Hsiung GY, Huey ED, Irwin D, Kantarci K, Kaufer D, Kerwin D, Knopman D, Kornak J, Kramer JH, Litvan I, Mackenzie IR, Mendez M, Miller B, Rademakers R, Ramos EM, Rascovsky K, Roberson ED, Syrjanen JA, Tartaglia MC, Weintraub S, Boeve B, Boxer AL, Rosen H, Yaffe K. Active lifestyles moderate clinical outcomes in autosomal dominant frontotemporal degeneration. Alzheimers Dement. 2020 01; 16(1):91-105. PMID: 31914227.
      View in: PubMed
    9. Hiramoto JS, Elahi FM, Gasper WJ, Reilly LM, Chuter TA, Goetzl EJ. Acute Insulin Resistance and Rapid Alterations in Neuronal Derived Blood Exosome Concentration After Branched Endovascular Aortic Aneurysm Repair. Eur J Vasc Endovasc Surg. 2020 Mar; 59(3):457-463. PMID: 31866237.
      View in: PubMed
    10. Elahi FM, Farwell DG, Nolta JA, Anderson JD. Preclinical translation of exosomes derived from mesenchymal stem/stromal cells. Stem Cells. 2020 01; 38(1):15-21. PMID: 31381842.
      View in: PubMed
    11. Lindbergh CA, Casaletto KB, Staffaroni AM, Elahi F, Walters SM, You M, Neuhaus J, Rivera Contreras W, Wang P, Karydas A, Brown J, Wolf A, Rosen H, Cobigo Y, Kramer JH. Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults. J Gerontol A Biol Sci Med Sci. 2019 Sep 24. PMID: 31549145.
      View in: PubMed
    12. Filshtein TJ, Brenowitz WD, Mayeda ER, Hohman TJ, Walter S, Jones RN, Elahi FM, Glymour MM. Reserve and Alzheimer's disease genetic risk: Effects on hospitalization and mortality. Alzheimers Dement. 2019 07; 15(7):907-916. PMID: 31327391.
      View in: PubMed
    13. Sophia A. Weiner-Light, Samantha Walters, Nina Djukic, Michelle You, Devyn Cotter, Marie Altendahl, Fanny Elahi, Adam M. Staffaroni, Cutter A. Lindbergh, Joel H. Kramer, Kaitlin B. Casaletto. STEP COUNT AND PSYCHOLOGICAL HEALTH IN OLDER ADULTS. Alzheimer's & Dementia. 2019 Jul 1; 15(7):p846-p847.
      View in: Publisher Site
    14. Goetzl EJ, Ledreux A, Granholm AC, Elahi FM, Goetzl L, Hiramoto J, Kapogiannis D. Neuron-Derived Exosome Proteins May Contribute to Progression From Repetitive Mild Traumatic Brain Injuries to Chronic Traumatic Encephalopathy. Front Neurosci. 2019; 13:452. PMID: 31133789.
      View in: PubMed
    15. Staffaroni AM, Cobigo Y, Elahi FM, Casaletto KB, Walters SM, Wolf A, Lindbergh CA, Rosen HJ, Kramer JH. A longitudinal characterization of perfusion in the aging brain and associations with cognition and neural structure. Hum Brain Mapp. 2019 08 15; 40(12):3522-3533. PMID: 31062904.
      View in: PubMed
    16. Bettcher BM, Neuhaus J, Wynn MJ, Elahi FM, Casaletto KB, Saloner R, Fitch R, Karydas A, Kramer JH. Increases in a Pro-inflammatory Chemokine, MCP-1, Are Related to Decreases in Memory Over Time. Front Aging Neurosci. 2019; 11:25. PMID: 30814948.
      View in: PubMed
    17. Staffaroni AM, Ljubenkov PA, Kornak J, Cobigo Y, Datta S, Marx G, Walters SM, Chiang K, Olney N, Elahi FM, Knopman DS, Dickerson BC, Boeve BF, Gorno-Tempini ML, Spina S, Grinberg LT, Seeley WW, Miller BL, Kramer JH, Boxer AL, Rosen HJ. Longitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials. Brain. 2019 02 01; 142(2):443-459. PMID: 30698757.
      View in: PubMed
    18. Casaletto KB, Elahi FM, Staffaroni AM, Walters S, Contreras WR, Wolf A, Dubal D, Miller B, Yaffe K, Kramer JH. Cognitive aging is not created equally: differentiating unique cognitive phenotypes in "normal" adults. Neurobiol Aging. 2019 05; 77:13-19. PMID: 30772736.
      View in: PubMed
    19. Winston CN, Goetzl EJ, Schwartz JB, Elahi FM, Rissman RA. Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease dementia. Alzheimers Dement (Amst). 2019 Dec; 11:61-66. PMID: 31032394.
      View in: PubMed
    20. Goetzl EJ, Elahi FM, Mustapic M, Kapogiannis D, Pryhoda M, Gilmore A, Gorgens KA, Davidson B, Granholm AC, Ledreux A. Altered levels of plasma neuron-derived exosomes and their cargo proteins characterize acute and chronic mild traumatic brain injury. FASEB J. 2019 04; 33(4):5082-5088. PMID: 30605353.
      View in: PubMed
    21. Broce IJ, Tan CH, Fan CC, Jansen I, Savage JE, Witoelar A, Wen N, Hess CP, Dillon WP, Glastonbury CM, Glymour M, Yokoyama JS, Elahi FM, Rabinovici GD, Miller BL, Mormino EC, Sperling RA, Bennett DA, McEvoy LK, Brewer JB, Feldman HH, Hyman BT, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Schellenberg GD, Yaffe K, Sugrue LP, Dale AM, Posthuma D, Andreassen OA, Karch CM, Desikan RS. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease. Acta Neuropathol. 2019 02; 137(2):209-226. PMID: 30413934.
      View in: PubMed
    22. Elahi FM, Casaletto KB, Altendahl M, Staffaroni AM, Fletcher E, Filshtein TJ, Glymour MM, Miller BL, Hinman JD, DeCarli C, Goetzl EJ, Kramer JH. "Liquid Biopsy" of White Matter Hyperintensity in Functionally Normal Elders. Front Aging Neurosci. 2018; 10:343. PMID: 30483114.
      View in: PubMed
    23. Viodé A, Fournier C, Camuzat A, Fenaille F, Latouche M, Elahi F, Le Ber I, Junot C, Lamari F, Anquetil V, Becher F. New Antibody-Free Mass Spectrometry-Based Quantification Reveals That C9ORF72 Long Protein Isoform Is Reduced in the Frontal Cortex of Hexanucleotide-Repeat Expansion Carriers. Front Neurosci. 2018; 12:589. PMID: 30210275.
      View in: PubMed
    24. Fanny Elahi, Marie Altendahl, Teresa J. Filshtein, Kaitlin Casaletto, Adam M. Staffaroni, Wilfredo Rivera Contreras, Anna M. Karydas, Yann Cobigo, Evan Fletcher, Baljeet Singh, Oliver Martinez, Howard J. Rosen, Jason Hinman, Katerina Akassoglou, Maria Glymour, Charlie S. DeCarli, Edward J. Goetzl, Joel H. Kramer. ENDOTHELIAL-DERIVED EXOSOME BIOMARKERS SUGGEST ACTIVATION OF INNATE IMMUNITY IN SUBCLINICAL CEREBROVASCULAR DISEASE. Alzheimer's & Dementia. 2018 Jul 1; 14(7):p767.
      View in: Publisher Site
    25. Casaletto KB, Staffaroni AM, Elahi F, Fox E, Crittenden PA, You M, Neuhaus J, Glymour M, Bettcher BM, Yaffe K, Kramer JH. Perceived Stress is Associated with Accelerated Monocyte/Macrophage Aging Trajectories in Clinically Normal Adults. Am J Geriatr Psychiatry. 2018 09; 26(9):952-963. PMID: 30017239.
      View in: PubMed
    26. Casaletto KB, Elahi FM, Fitch R, Walters S, Fox E, Staffaroni AM, Bettcher BM, Zetterberg H, Karydas A, Rojas JC, Boxer AL, Kramer JH. A comparison of biofluid cytokine markers across platform technologies: Correspondence or divergence? Cytokine. 2018 11; 111:481-489. PMID: 29908923.
      View in: PubMed
    27. Staffaroni AM, Tosun D, Lin J, Elahi FM, Casaletto KB, Wynn MJ, Patel N, Neuhaus J, Walters SM, Epel ES, Blackburn EH, Kramer JH. Telomere attrition is associated with declines in medial temporal lobe volume and white matter microstructure in functionally independent older adults. Neurobiol Aging. 2018 09; 69:68-75. PMID: 29859365.
      View in: PubMed
    28. Staffaroni AM, Brown JA, Casaletto KB, Elahi FM, Deng J, Neuhaus J, Cobigo Y, Mumford PS, Walters S, Saloner R, Karydas A, Coppola G, Rosen HJ, Miller BL, Seeley WW, Kramer JH. The Longitudinal Trajectory of Default Mode Network Connectivity in Healthy Older Adults Varies As a Function of Age and Is Associated with Changes in Episodic Memory and Processing Speed. J Neurosci. 2018 03 14; 38(11):2809-2817. PMID: 29440553.
      View in: PubMed
    29. Staffaroni AM, Elahi FM, McDermott D, Marton K, Karageorgiou E, Sacco S, Paoletti M, Caverzasi E, Hess CP, Rosen HJ, Geschwind MD. Neuroimaging in Dementia. Semin Neurol. 2017 10; 37(5):510-537. PMID: 29207412.
      View in: PubMed
    30. Casaletto KB, Elahi FM, Bettcher BM, Neuhaus J, Bendlin BB, Asthana S, Johnson SC, Yaffe K, Carlsson C, Blennow K, Zetterberg H, Kramer JH. Neurogranin, a synaptic protein, is associated with memory independent of Alzheimer biomarkers. Neurology. 2017 Oct 24; 89(17):1782-1788. PMID: 28939668.
      View in: PubMed
    31. Elahi FM, Marx G, Cobigo Y, Staffaroni AM, Kornak J, Tosun D, Boxer AL, Kramer JH, Miller BL, Rosen HJ. Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease. Neuroimage Clin. 2017; 16:595-603. PMID: 28975068.
      View in: PubMed
    32. Elahi FM, Miller BL. A clinicopathological approach to the diagnosis of dementia. Nat Rev Neurol. 2017 Aug; 13(8):457-476. PMID: 28708131.
      View in: PubMed
    33. Emmanuel During, Fanny Elahi, Kewei Chen, Matthew Huentelman, Jason Corneveaux, Pradeep Thiyyagura, Xiaofen Liu, Auttawut Roontiva, Richard Caselli, Adam Fleisher, Bai Lu, Eric Reiman. Independent and epistatic effects of Val66Met BDNF and ApoE polymorphisms on BETA-AMYLOID deposition in cognitively normal individuals using PiB-PET imaging. Alzheimer's & Dementia. 2012 Jul 1; 8(4):s757-s758.
      View in: Publisher Site
    34. During EH, Osorio RS, Elahi FM, Mosconi L, de Leon MJ. The concept of FDG-PET endophenotype in Alzheimer's disease. Neurol Sci. 2011 Aug; 32(4):559-69. PMID: 21630036.
      View in: PubMed
    35. During EH, Elahi FM, Taieb O, Moro MR, Baubet T. A critical review of dissociative trance and possession disorders: etiological, diagnostic, therapeutic, and nosological issues. Can J Psychiatry. 2011 Apr; 56(4):235-42. PMID: 21507280.
      View in: PubMed
    36. Vernes SC, Nicod J, Elahi FM, Coventry JA, Kenny N, Coupe AM, Bird LE, Davies KE, Fisher SE. Functional genetic analysis of mutations implicated in a human speech and language disorder. Hum Mol Genet. 2006 Nov 01; 15(21):3154-67. PMID: 16984964.
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