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Feroz Papa, MD, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
Address1700 4th St
San Francisco CA 94158
Phone415-476-2117
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division

    Collapse Research 
    Collapse Research Activities and Funding
    Pharmacological Validation of IRE1 for Diabetes Mellitus
    NIH/NIDDK R01DK100623Jan 1, 2014 - Dec 31, 2017
    Role: Principal Investigator
    Attenuating ER and oxidative stress signaling to reduce cell degeneration in vivo
    NIH/NIDDK R01DK095306Aug 1, 2013 - Jul 31, 2017
    Role: Principal Investigator
    Targeting epithelial cells to treat pulmonary fibrosis
    NIH/NHLBI P01HL108794Aug 9, 2012 - Jul 31, 2017
    Role: Co-Investigator
    "Expanding beta-cell mass"
    NIH/NIDDK U01DK089541Sep 15, 2010 - Jun 30, 2015
    Role: Co-Principal Investigator
    Cytoprotection of Beta Cells Through Modulation of Ire1Alpha Function
    NIH/NIDDK R01DK080955Apr 1, 2008 - May 31, 2018
    Role: Principal Investigator
    HTS to discover drugs effecting protein folding in the endoplasmic reticulum
    NIH/NIDDK R21DK080321Mar 1, 2008 - Feb 28, 2010
    Role: Principal Investigator
    New Tools to Measure and Correct Endoplasmic Reticulum Stress in Single Living
    NIH DP2OD001925Sep 30, 2007 - Aug 31, 2012
    Role: Principal Investigator
    Role of the Unfolded Protein Response in Type 2 Diabetes
    NIH/NIDDK K08DK065671Jul 1, 2004 - Jun 30, 2009
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa F. Targeting ABL-IRE1a Signaling Spares ER-Stressed Pancreatic ß Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 Apr 04; 25(4):883-897.e8. PMID: 28380378.
      View in: PubMed
    2. Papa F, Lippolis R, Sardaro N, Gnoni A, Scacco S. All trans retinoic acid depresses the content and activity of the mitochondrial ATP synthase in human keratinocytes. Biochem Biophys Res Commun. 2017 Jan 08; 482(2):301-304. PMID: 27856255.
      View in: PubMed
    3. Feldman HC, Tong M, Wang L, Meza-Acevedo R, Gobillot TA, Lebedev I, Gliedt MJ, Hari SB, Mitra AK, Backes BJ, Papa F, Seeliger MA, Maly DJ. Structural and Functional Analysis of the Allosteric Inhibition of IRE1a with ATP-Competitive Ligands. ACS Chem Biol. 2016 Aug 19; 11(8):2195-205. PMID: 27227314.
      View in: PubMed
    4. Valentine CD, Anderson MO, Papa F, Haggie PM. Correction: X-Box Binding Protein 1 (XBP1s) Is a Critical Determinant of Pseudomonas aeruginosa Homoserine Lactone-Mediated Apoptosis. PLoS Pathog. 2016 May; 12(5):e1005628. PMID: 27191388.
      View in: PubMed
    5. Maly DJ, Papa F. Druggable sensors of the unfolded protein response. Nat Chem Biol. 2014 Nov; 10(11):892-901. PMID: 25325700.
      View in: PubMed
    6. Oakes SA, Papa F. The role of endoplasmic reticulum stress in human pathology. Annu Rev Pathol. 2015; 10:173-94. PMID: 25387057.
      View in: PubMed
    7. Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa F. Allosteric inhibition of the IRE1a RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 2014 Jul 31; 158(3):534-48. PMID: 25018104; PMCID: PMC4244221.
    8. Sedwick C, Papa F. Feroz Papa: Saving cells from themselves. J Cell Biol. 2014 Mar 3; 204(5):628-9. PMID: 24590168; PMCID: PMC3941043.
    9. Kanekura K, Ishigaki S, Merksamer PI, Papa F, Urano F. Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells. Lab Invest. 2013 Nov; 93(11):1254-8. PMID: 24042438; PMCID: PMC4090936.
    10. Valentine CD, Anderson MO, Papa F, Haggie PM. X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis. PLoS Pathog. 2013; 9(8):e1003576. PMID: 23990788; PMCID: PMC3749957.
    11. Cha SI, Ryerson CJ, Lee JS, Kukreja J, Barry SS, Jones KD, Elicker BM, Kim DS, Papa F, Collard HR, Wolters PJ. Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis. Respir Res. 2012; 13:105. PMID: 23167970; PMCID: PMC3547729.
    12. Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schürer SC, Oakes SA, Papa F, Maly DJ. Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012 Dec; 8(12):982-9. PMID: 23086298; PMCID: PMC3508346.
    13. Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa F, Oakes SA. IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science. 2012 Nov 9; 338(6108):818-22. PMID: 23042294; PMCID: PMC3742121.
    14. Papa F. Endoplasmic reticulum stress, pancreatic ß-cell degeneration, and diabetes. Cold Spring Harb Perspect Med. 2012 Sep; 2(9):a007666. PMID: 22951443; PMCID: PMC3426819.
    15. Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa F. IRE1a induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab. 2012 Aug 8; 16(2):250-64. PMID: 22883233; PMCID: PMC4014071.
    16. Meares GP, Hughes KJ, Naatz A, Papa F, Urano F, Hansen PA, Benveniste EN, Corbett JA. IRE1-dependent activation of AMPK in response to nitric oxide. Mol Cell Biol. 2011 Nov; 31(21):4286-97. PMID: 21896783; PMCID: PMC3209336.
    17. Shore GC, Papa F, Oakes SA. Signaling cell death from the endoplasmic reticulum stress response. Curr Opin Cell Biol. 2011 Apr; 23(2):143-9. PMID: 21146390; PMCID: PMC3078187.
    18. Merksamer PI, Papa F. The UPR and cell fate at a glance. J Cell Sci. 2010 Apr 1; 123(Pt 7):1003-6. PMID: 20332117; PMCID: PMC2844313.
    19. Lei X, Zhang S, Barbour SE, Bohrer A, Ford EL, Koizumi A, Papa F, Ramanadham S. Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1. J Biol Chem. 2010 Feb 26; 285(9):6693-705. PMID: 20032468; PMCID: PMC2825464.
    20. Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa F. IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell. 2009 Aug 7; 138(3):562-75. PMID: 19665977; PMCID: PMC2762408.
    21. Trusina A, Papa F, Tang C. Rationalizing translation attenuation in the network architecture of the unfolded protein response. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20280-5. PMID: 19075238.
      View in: PubMed
    22. Merksamer PI, Trusina A, Papa F. Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions. Cell. 2008 Nov 28; 135(5):933-47. PMID: 19026441; PMCID: PMC2739138.
    23. Upton JP, Austgen K, Nishino M, Coakley KM, Hagen A, Han D, Papa F, Oakes SA. Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biol. 2008 Jun; 28(12):3943-51. PMID: 18426910; PMCID: PMC2423129.
    24. Han D, Upton JP, Hagen A, Callahan J, Oakes SA, Papa F. A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress. Biochem Biophys Res Commun. 2008 Jan 25; 365(4):777-83. PMID: 18035051.
      View in: PubMed
    25. Bernales S, Papa F, Walter P. Intracellular signaling by the unfolded protein response. Annu Rev Cell Dev Biol. 2006; 22:487-508. PMID: 16822172.
      View in: PubMed
    26. Credle JJ, Finer-Moore JS, Papa F, Stroud RM, Walter P. On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18773-84. PMID: 16365312; PMCID: PMC1316886.
    27. Papa F, Zhang C, Shokat K, Walter P. Bypassing a kinase activity with an ATP-competitive drug. Science. 2003 Nov 28; 302(5650):1533-7. PMID: 14564015.
      View in: PubMed
    28. Papa F, Amerik AY, Hochstrasser M. Interaction of the Doa4 deubiquitinating enzyme with the yeast 26S proteasome. Mol Biol Cell. 1999 Mar; 10(3):741-56. PMID: 10069815; PMCID: PMC25199.
    29. DeMarini DJ, Papa F, Swaminathan S, Ursic D, Rasmussen TP, Culbertson MR, Hochstrasser M. The yeast SEN3 gene encodes a regulatory subunit of the 26S proteasome complex required for ubiquitin-dependent protein degradation in vivo. Mol Cell Biol. 1995 Nov; 15(11):6311-21. PMID: 7565784; PMCID: PMC230883.
    30. Hochstrasser M, Papa F, Chen P, Swaminathan S, Johnson P, Stillman L, Amerik AY, Li SJ. The DOA pathway: studies on the functions and mechanisms of ubiquitin-dependent protein degradation in the yeast Saccharomyces cerevisiae. Cold Spring Harb Symp Quant Biol. 1995; 60:503-13. PMID: 8824423.
      View in: PubMed
    31. Papa F, Hochstrasser M. The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene. Nature. 1993 Nov 25; 366(6453):313-9. PMID: 8247125.
      View in: PubMed
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