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Feroz Papa, MD, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address1700 4th St
San Francisco CA 94158
Phone415-476-2117
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    Collapse Biography 
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    University of California, San FranciscoPostdoctoral StudiesGraduate Division

    Collapse Research 
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    Partial Antagonists of IRE1 RNase—‘PAIR’s—to treat Type 1 Diabetes
    NIH U01DK123609Sep 20, 2019 - Jul 31, 2023
    Role: Principal Investigator
    Interventional Targeting of the IRE1alpha-TGFbeta signaling loop in pulmonary fibrosis
    NIH R01HL145037Jan 15, 2019 - Dec 31, 2022
    Role: Co-Principal Investigator
    Role of the Unfolded Protein Response in Photoreceptor Degeneration
    NIH R01EY027810Feb 1, 2018 - Jan 31, 2023
    Role: Co-Principal Investigator
    Interrogation of the Roles of Tyrosine Kinases in the Unfolded Protein Response
    NIH R01DK116064Jan 1, 2018 - Dec 31, 2021
    Role: Co-Principal Investigator
    Developing UPR inhibitory KIRAs into oral antidiabetic beta cell-sparing drugs
    NIH R01DK100623Jan 1, 2014 - Jun 30, 2023
    Role: Principal Investigator
    Attenuating ER and oxidative stress signaling to reduce cell degeneration in vivo
    NIH R01DK095306Aug 1, 2013 - Jul 31, 2018
    Role: Principal Investigator
    Targeting epithelial cells to treat pulmonary fibrosis
    NIH P01HL108794Aug 9, 2012 - Jul 31, 2018
    Role: Co-Investigator
    Expanding beta-cell mass
    NIH U01DK089541Sep 15, 2010 - Jun 30, 2015
    Role: Co-Principal Investigator
    Cytoprotection of Beta Cells Through Modulation of Ire1Alpha Function
    NIH R01DK080955Apr 1, 2008 - May 31, 2019
    Role: Principal Investigator
    HTS to discover drugs effecting protein folding in the endoplasmic reticulum
    NIH R21DK080321Mar 1, 2008 - Feb 28, 2010
    Role: Principal Investigator
    New Tools to Measure and Correct Endoplasmic Reticulum Stress in Single Living
    NIH DP2OD001925Sep 30, 2007 - Aug 31, 2012
    Role: Principal Investigator
    Role of the Unfolded Protein Response in Type 2 Diabetes
    NIH K08DK065671Jul 1, 2004 - Jun 30, 2009
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Targeting Adaptive IRE1a Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib. Int J Mol Sci. 2020 Aug 31; 21(17). Yamashita Y, Morita S, Hosoi H, Kobata H, Kishimoto S, Ishibashi T, Mishima H, Kinoshita A, Backes BJ, Yoshiura KI, Papa FR, Sonoki T, Tamura S. PMID: 32878237.
      View in: PubMed   Mentions:    Fields:    
    2. Nicotinic acetylcholine receptor signaling regulates inositol-requiring enzyme 1a activation to protect ß-cells against terminal unfolded protein response under irremediable endoplasmic reticulum stress. J Diabetes Investig. 2020 Jul; 11(4):801-813. Ishibashi T, Morita S, Kishimoto S, Uraki S, Takeshima K, Furukawa Y, Inaba H, Ariyasu H, Iwakura H, Furuta H, Nishi M, Papa FR, Akamizu T. PMID: 31925927.
      View in: PubMed   Mentions: 2     Fields:    
    3. Parallel Signaling through IRE1a and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival. Cancer Res. 2019 12 15; 79(24):6190-6203. Moore PC, Qi JY, Thamsen M, Ghosh R, Peng J, Gliedt MJ, Meza-Acevedo R, Warren RE, Hiniker A, Kim GE, Maly DJ, Backes BJ, Papa FR, Oakes SA. PMID: 31672843.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    4. Development of a Chemical Toolset for Studying the Paralog-Specific Function of IRE1. ACS Chem Biol. 2019 12 20; 14(12):2595-2605. Feldman HC, Vidadala VN, Potter ZE, Papa FR, Backes BJ, Maly DJ. PMID: 31609569.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Endoplasmic reticulum stress, degeneration of pancreatic islet ß-cells, and therapeutic modulation of the unfolded protein response in diabetes. Mol Metab. 2019 09; 27S:S60-S68. Ghosh R, Colon-Negron K, Papa FR. PMID: 31500832.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    6. Small Molecules to Improve ER Proteostasis in Disease. Trends Pharmacol Sci. 2019 09; 40(9):684-695. Gonzalez-Teuber V, Albert-Gasco H, Auyeung VC, Papa FR, Mallucci GR, Hetz C. PMID: 31377018.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    7. Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress. Proc Natl Acad Sci U S A. 2019 06 04; 116(23):11291-11298. Igbaria A, Merksamer PI, Trusina A, Tilahun F, Johnson JR, Brandman O, Krogan NJ, Weissman JS, Papa FR. PMID: 31101715.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    8. Small molecule inhibition of IRE1a kinase/RNase has anti-fibrotic effects in the lung. PLoS One. 2019; 14(1):e0209824. Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR. PMID: 30625178.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    9. Pancreatic Neuroendocrine Tumors Require Homeostatic Signaling from the Unfolded Protein Response. The FASEB Journal. 2018 Apr 1; 32:407.12-407.12. Scott A. Oakes, Paul C. Moore, Jenny Y. Qi, Rachel Warren, Maike Thamsen, Rajarshi Ghosh, Micah J. Gliedt, Anne Hiniker, Grace E. Kim, Dustin J. Maly, Bradley J. Backes, Feroz R. Papa. .
      View in: Publisher Site   Mentions:
    10. The Unfolded Protein Response and Cell Fate Control. Mol Cell. 2018 01 18; 69(2):169-181. Hetz C, Papa FR. PMID: 29107536.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansAnimalsCells
    11. Targeting ABL-IRE1a Signaling Spares ER-Stressed Pancreatic ß Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 05 02; 25(5):1207. Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR. PMID: 28467938.
      View in: PubMed   Mentions: 7     Fields:    
    12. Targeting ABL-IRE1a Signaling Spares ER-Stressed Pancreatic ß Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 Apr 04; 25(4):883-897.e8. Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR. PMID: 28380378.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    13. All trans retinoic acid depresses the content and activity of the mitochondrial ATP synthase in human keratinocytes. Biochem Biophys Res Commun. 2017 Jan 08; 482(2):301-304. Papa F, Lippolis R, Sardaro N, Gnoni A, Scacco S. PMID: 27856255.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    14. Structural and Functional Analysis of the Allosteric Inhibition of IRE1a with ATP-Competitive Ligands. ACS Chem Biol. 2016 08 19; 11(8):2195-205. Feldman HC, Tong M, Wang L, Meza-Acevedo R, Gobillot TA, Lebedev I, Gliedt MJ, Hari SB, Mitra AK, Backes BJ, Papa FR, Seeliger MA, Maly DJ. PMID: 27227314.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    15. Correction: X-Box Binding Protein 1 (XBP1s) Is a Critical Determinant of Pseudomonas aeruginosa Homoserine Lactone-Mediated Apoptosis. PLoS Pathog. 2016 May; 12(5):e1005628. Valentine CD, Anderson MO, Papa FR, Haggie PM. PMID: 27191388.
      View in: PubMed   Mentions:    Fields:    
    16. COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. Nat Genet. 2015 Jun; 47(6):654-60. Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, Anderson MS, Liu D, Tang LF, Nicholas SK, Nahmod K, Makedonas G, Canter DL, Kwok PY, Hicks J, Jones KD, Penney S, Jhangiani SN, Rosenblum MD, Dell SD, Waterfield MR, Papa FR, Muzny DM, Zaitlen N, Leal SM, Gonzaga-Jauregui C, , Boerwinkle E, Eissa NT, Gibbs RA, Lupski JR, Orange JS, Shum AK. PMID: 25894502.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    17. Druggable sensors of the unfolded protein response. Nat Chem Biol. 2014 Nov; 10(11):892-901. Maly DJ, Papa FR. PMID: 25325700.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    18. The role of endoplasmic reticulum stress in human pathology. Annu Rev Pathol. 2015; 10:173-94. Oakes SA, Papa FR. PMID: 25387057.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansAnimalsCells
    19. Allosteric inhibition of the IRE1a RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 2014 Jul 31; 158(3):534-48. Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa FR. PMID: 25018104.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    20. Feroz Papa: Saving cells from themselves. J Cell Biol. 2014 Mar 03; 204(5):628-9. Sedwick C, Papa F. PMID: 24590168.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    21. Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells. Lab Invest. 2013 Nov; 93(11):1254-8. Kanekura K, Ishigaki S, Merksamer PI, Papa FR, Urano F. PMID: 24042438.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    22. X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis. PLoS Pathog. 2013; 9(8):e1003576. Valentine CD, Anderson MO, Papa FR, Haggie PM. PMID: 23990788.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    23. Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis. Respir Res. 2012 Nov 20; 13:105. Cha SI, Ryerson CJ, Lee JS, Kukreja J, Barry SS, Jones KD, Elicker BM, Kim DS, Papa FR, Collard HR, Wolters PJ. PMID: 23167970.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    24. Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012 Dec; 8(12):982-9. Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schürer SC, Oakes SA, Papa FR, Maly DJ. PMID: 23086298.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    25. IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science. 2012 Nov 09; 338(6108):818-22. Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA. PMID: 23042294.
      View in: PubMed   Mentions: 207     Fields:    Translation:HumansAnimalsCells
    26. Endoplasmic reticulum stress, pancreatic ß-cell degeneration, and diabetes. Cold Spring Harb Perspect Med. 2012 Sep 01; 2(9):a007666. Papa FR. PMID: 22951443.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    27. IRE1a induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab. 2012 Aug 08; 16(2):250-64. Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR. PMID: 22883233.
      View in: PubMed   Mentions: 243     Fields:    Translation:HumansAnimalsCells
    28. IRE1-dependent activation of AMPK in response to nitric oxide. Mol Cell Biol. 2011 Nov; 31(21):4286-97. Meares GP, Hughes KJ, Naatz A, Papa FR, Urano F, Hansen PA, Benveniste EN, Corbett JA. PMID: 21896783.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    29. Signaling cell death from the endoplasmic reticulum stress response. Curr Opin Cell Biol. 2011 Apr; 23(2):143-9. Shore GC, Papa FR, Oakes SA. PMID: 21146390.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    30. The UPR and cell fate at a glance. J Cell Sci. 2010 Apr 01; 123(Pt 7):1003-6. Merksamer PI, Papa FR. PMID: 20332117.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    31. Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1. J Biol Chem. 2010 Feb 26; 285(9):6693-705. Lei X, Zhang S, Barbour SE, Bohrer A, Ford EL, Koizumi A, Papa FR, Ramanadham S. PMID: 20032468.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    32. IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell. 2009 Aug 07; 138(3):562-75. Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR. PMID: 19665977.
      View in: PubMed   Mentions: 325     Fields:    Translation:AnimalsCells
    33. IRE1a Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates. Journal of End-to-End-testing. 2009 Aug 7; 138(33):562-575. Dan Han, Alana G. Lerner, Lieselotte Vande Walle, John-Paul Upton, Weihong Xu, Andrew Hagen, Bradley J. Backes, Scott A. Oakes, Feroz R. Papa. .
      View in: Publisher Site   Mentions:
    34. IRE1a Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates. Journal of End-to-End-testing. 2009 Aug 7; 138(3):562-575. Dan Han, Alana G. Lerner, Lieselotte Vande Walle, John-Paul Upton, Weihong Xu, Andrew Hagen, Bradley J. Backes, Scott A. Oakes, Feroz R. Papa. .
      View in: Publisher Site   Mentions:
    35. Rationalizing translation attenuation in the network architecture of the unfolded protein response. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20280-5. Trusina A, Papa FR, Tang C. PMID: 19075238.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    36. Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions. Cell. 2008 Nov 28; 135(5):933-47. Merksamer PI, Trusina A, Papa FR. PMID: 19026441.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    37. Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biol. 2008 Jun; 28(12):3943-51. Upton JP, Austgen K, Nishino M, Coakley KM, Hagen A, Han D, Papa FR, Oakes SA. PMID: 18426910.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    38. Translation Attenuation Mechanism in Unfolded Protein Response. Evolution from Cellular to Social Scales. 2008 Jan 1; 83-90. Ala Trusina, Feroz Papa, Chao Tang. .
      View in: Publisher Site   Mentions:
    39. A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress. Biochem Biophys Res Commun. 2008 Jan 25; 365(4):777-83. Han D, Upton JP, Hagen A, Callahan J, Oakes SA, Papa FR. PMID: 18035051.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    40. Intracellular signaling by the unfolded protein response. Annu Rev Cell Dev Biol. 2006; 22:487-508. Bernales S, Papa FR, Walter P. PMID: 16822172.
      View in: PubMed   Mentions: 240     Fields:    Translation:AnimalsCells
    41. On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18773-84. Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P. PMID: 16365312.
      View in: PubMed   Mentions: 194     Fields:    Translation:HumansAnimalsCells
    42. Bypassing a kinase activity with an ATP-competitive drug. Science. 2003 Nov 28; 302(5650):1533-7. Papa FR, Zhang C, Shokat K, Walter P. PMID: 14564015.
      View in: PubMed   Mentions: 100     Fields:    Translation:Cells
    43. Interaction of the Doa4 deubiquitinating enzyme with the yeast 26S proteasome. Mol Biol Cell. 1999 Mar; 10(3):741-56. Papa FR, Amerik AY, Hochstrasser M. PMID: 10069815.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    44. An evolutionarily conserved gene on human chromosome 5q33-q34, UBH1, encodes a novel deubiquitinating enzyme. Genomics. 1998 May 01; 49(3):411-8. Hansen-Hagge TE, Janssen JW, Hameister H, Papa FR, Zechner U, Seriu T, Jauch A, Becke D, Hochstrasser M, Bartram CR. PMID: 9615226.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    45. DUB-1, a deubiquitinating enzyme with growth-suppressing activity. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3275-9. Zhu Y, Carroll M, Papa FR, Hochstrasser M, D'Andrea AD. PMID: 8622927.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    46. The yeast SEN3 gene encodes a regulatory subunit of the 26S proteasome complex required for ubiquitin-dependent protein degradation in vivo. Mol Cell Biol. 1995 Nov; 15(11):6311-21. DeMarini DJ, Papa FR, Swaminathan S, Ursic D, Rasmussen TP, Culbertson MR, Hochstrasser M. PMID: 7565784.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    47. The DOA pathway: studies on the functions and mechanisms of ubiquitin-dependent protein degradation in the yeast Saccharomyces cerevisiae. Cold Spring Harb Symp Quant Biol. 1995; 60:503-13. Hochstrasser M, Papa FR, Chen P, Swaminathan S, Johnson P, Stillman L, Amerik AY, Li SJ. PMID: 8824423.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    48. The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene. Nature. 1993 Nov 25; 366(6453):313-9. Papa FR, Hochstrasser M. PMID: 8247125.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
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