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Feroz Papa, MD, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address1700 4th St
San Francisco CA 94158
Phone415-476-2117
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division

    Collapse Research 
    Collapse Research Activities and Funding
    Role of the Unfolded Protein Response in Photoreceptor Degeneration
    NIH/NEI R01EY027810Feb 1, 2018 - Jan 31, 2023
    Role: Co-Principal Investigator
    Interrogation of the roles of tyrosine kinases in the unfolded protein response
    NIH/NIDDK R01DK116064Jan 1, 2018 - Dec 31, 2022
    Role: Co-Principal Investigator
    Pharmacological Validation of IRE1 for Diabetes Mellitus
    NIH/NIDDK R01DK100623Jan 1, 2014 - Dec 31, 2017
    Role: Principal Investigator
    Attenuating ER and oxidative stress signaling to reduce cell degeneration in vivo
    NIH/NIDDK R01DK095306Aug 1, 2013 - Jul 31, 2017
    Role: Principal Investigator
    Targeting epithelial cells to treat pulmonary fibrosis
    NIH/NHLBI P01HL108794Aug 9, 2012 - Jul 31, 2017
    Role: Co-Investigator
    "Expanding beta-cell mass"
    NIH/NIDDK U01DK089541Sep 15, 2010 - Jun 30, 2015
    Role: Co-Principal Investigator
    Cytoprotection of Beta Cells Through Modulation of Ire1Alpha Function
    NIH/NIDDK R01DK080955Apr 1, 2008 - May 31, 2018
    Role: Principal Investigator
    HTS to discover drugs effecting protein folding in the endoplasmic reticulum
    NIH/NIDDK R21DK080321Mar 1, 2008 - Feb 28, 2010
    Role: Principal Investigator
    New Tools to Measure and Correct Endoplasmic Reticulum Stress in Single Living
    NIH DP2OD001925Sep 30, 2007 - Aug 31, 2012
    Role: Principal Investigator
    Role of the Unfolded Protein Response in Type 2 Diabetes
    NIH/NIDDK K08DK065671Jul 1, 2004 - Jun 30, 2009
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hetz C, Papa F. The Unfolded Protein Response and Cell Fate Control. Mol Cell. 2018 Jan 18; 69(2):169-181. PMID: 29107536.
      View in: PubMed
    2. Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa F. Targeting ABL-IRE1a Signaling Spares ER-Stressed Pancreatic ß Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 05 02; 25(5):1207. PMID: 28467938.
      View in: PubMed
    3. Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa F. Targeting ABL-IRE1a Signaling Spares ER-Stressed Pancreatic ß Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 Apr 04; 25(4):883-897.e8. PMID: 28380378.
      View in: PubMed
    4. Feldman HC, Tong M, Wang L, Meza-Acevedo R, Gobillot TA, Lebedev I, Gliedt MJ, Hari SB, Mitra AK, Backes BJ, Papa F, Seeliger MA, Maly DJ. Structural and Functional Analysis of the Allosteric Inhibition of IRE1a with ATP-Competitive Ligands. ACS Chem Biol. 2016 08 19; 11(8):2195-205. PMID: 27227314; PMCID: PMC4992410 [Available on 08/19/17].
      View in: PubMed, PubMed Central
    5. Valentine CD, Anderson MO, Papa F, Haggie PM. Correction: X-Box Binding Protein 1 (XBP1s) Is a Critical Determinant of Pseudomonas aeruginosa Homoserine Lactone-Mediated Apoptosis. PLoS Pathog. 2016 May; 12(5):e1005628. PMID: 27191388.
      View in: PubMed
    6. Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, Anderson MS, Liu D, Tang LF, Nicholas SK, Nahmod K, Makedonas G, Canter DL, Kwok PY, Hicks J, Jones KD, Penney S, Jhangiani SN, Rosenblum MD, Dell SD, Waterfield MR, Papa F, Muzny DM, Zaitlen N, Leal SM, Gonzaga-Jauregui C. COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. Nat Genet. 2015 Jun; 47(6):654-60. PMID: 25894502; PMCID: PMC4513663.
      View in: PubMed, PubMed Central
    7. Maly DJ, Papa F. Druggable sensors of the unfolded protein response. Nat Chem Biol. 2014 Nov; 10(11):892-901. PMID: 25325700; PMCID: PMC4664160.
      View in: PubMed, PubMed Central
    8. Oakes SA, Papa F. The role of endoplasmic reticulum stress in human pathology. Annu Rev Pathol. 2015; 10:173-94. PMID: 25387057.
      View in: PubMed
    9. Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa F. Allosteric inhibition of the IRE1a RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 2014 Jul 31; 158(3):534-48. PMID: 25018104; PMCID: PMC4244221.
      View in: PubMed, PubMed Central
    10. Sedwick C, Papa F. Feroz Papa: Saving cells from themselves. J Cell Biol. 2014 Mar 03; 204(5):628-9. PMID: 24590168; PMCID: PMC3941043.
      View in: PubMed, PubMed Central
    11. Kanekura K, Ishigaki S, Merksamer PI, Papa F, Urano F. Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells. Lab Invest. 2013 Nov; 93(11):1254-8. PMID: 24042438; PMCID: PMC4090936.
      View in: PubMed, PubMed Central
    12. Valentine CD, Anderson MO, Papa F, Haggie PM. X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis. PLoS Pathog. 2013; 9(8):e1003576. PMID: 23990788; PMCID: PMC3749957.
      View in: PubMed, PubMed Central
    13. Cha SI, Ryerson CJ, Lee JS, Kukreja J, Barry SS, Jones KD, Elicker BM, Kim DS, Papa F, Collard HR, Wolters PJ. Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis. Respir Res. 2012 Nov 20; 13:105. PMID: 23167970; PMCID: PMC3547729.
      View in: PubMed, PubMed Central
    14. Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schürer SC, Oakes SA, Papa F, Maly DJ. Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012 Dec; 8(12):982-9. PMID: 23086298; PMCID: PMC3508346.
      View in: PubMed, PubMed Central
    15. Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa F, Oakes SA. IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science. 2012 Nov 09; 338(6108):818-22. PMID: 23042294; PMCID: PMC3742121.
      View in: PubMed, PubMed Central
    16. Papa F. Endoplasmic reticulum stress, pancreatic ß-cell degeneration, and diabetes. Cold Spring Harb Perspect Med. 2012 Sep 01; 2(9):a007666. PMID: 22951443; PMCID: PMC3426819.
      View in: PubMed, PubMed Central
    17. Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa F. IRE1a induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab. 2012 Aug 08; 16(2):250-64. PMID: 22883233; PMCID: PMC4014071.
      View in: PubMed, PubMed Central
    18. Meares GP, Hughes KJ, Naatz A, Papa F, Urano F, Hansen PA, Benveniste EN, Corbett JA. IRE1-dependent activation of AMPK in response to nitric oxide. Mol Cell Biol. 2011 Nov; 31(21):4286-97. PMID: 21896783; PMCID: PMC3209336.
      View in: PubMed, PubMed Central
    19. Shore GC, Papa F, Oakes SA. Signaling cell death from the endoplasmic reticulum stress response. Curr Opin Cell Biol. 2011 Apr; 23(2):143-9. PMID: 21146390; PMCID: PMC3078187.
      View in: PubMed, PubMed Central
    20. Merksamer PI, Papa F. The UPR and cell fate at a glance. J Cell Sci. 2010 Apr 01; 123(Pt 7):1003-6. PMID: 20332117; PMCID: PMC2844313.
      View in: PubMed, PubMed Central
    21. Lei X, Zhang S, Barbour SE, Bohrer A, Ford EL, Koizumi A, Papa F, Ramanadham S. Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1. J Biol Chem. 2010 Feb 26; 285(9):6693-705. PMID: 20032468; PMCID: PMC2825464.
      View in: PubMed, PubMed Central
    22. Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa F. IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell. 2009 Aug 07; 138(3):562-75. PMID: 19665977; PMCID: PMC2762408.
      View in: PubMed, PubMed Central
    23. Trusina A, Papa F, Tang C. Rationalizing translation attenuation in the network architecture of the unfolded protein response. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20280-5. PMID: 19075238.
      View in: PubMed
    24. Merksamer PI, Trusina A, Papa F. Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions. Cell. 2008 Nov 28; 135(5):933-47. PMID: 19026441; PMCID: PMC2739138.
      View in: PubMed, PubMed Central
    25. Upton JP, Austgen K, Nishino M, Coakley KM, Hagen A, Han D, Papa F, Oakes SA. Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biol. 2008 Jun; 28(12):3943-51. PMID: 18426910; PMCID: PMC2423129.
      View in: PubMed, PubMed Central
    26. Han D, Upton JP, Hagen A, Callahan J, Oakes SA, Papa F. A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress. Biochem Biophys Res Commun. 2008 Jan 25; 365(4):777-83. PMID: 18035051.
      View in: PubMed
    27. Bernales S, Papa F, Walter P. Intracellular signaling by the unfolded protein response. Annu Rev Cell Dev Biol. 2006; 22:487-508. PMID: 16822172.
      View in: PubMed
    28. Credle JJ, Finer-Moore JS, Papa F, Stroud RM, Walter P. On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18773-84. PMID: 16365312; PMCID: PMC1316886.
      View in: PubMed, PubMed Central
    29. Papa F, Zhang C, Shokat K, Walter P. Bypassing a kinase activity with an ATP-competitive drug. Science. 2003 Nov 28; 302(5650):1533-7. PMID: 14564015.
      View in: PubMed
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