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Feroz Papa, MD, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Phone415-476-2117
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division

    Collapse Research 
    Collapse Research Activities and Funding
    Partial Antagonists of IRE1 RNase??PAIR?s?to treat Type 1 Diabetes
    NIH/NIDDK U01DK123609Sep 20, 2019 - Jul 31, 2023
    Role: Principal Investigator
    Interventional Targeting of the IRE1alpha-TGFbeta signaling loop in pulmonary fibrosis
    NIH/NHLBI R01HL145037Jan 15, 2019 - Dec 31, 2022
    Role: Co-Principal Investigator
    Role of the Unfolded Protein Response in Photoreceptor Degeneration
    NIH/NEI R01EY027810Feb 1, 2018 - Jan 31, 2023
    Role: Co-Principal Investigator
    Interrogation of the roles of tyrosine kinases in the unfolded protein response
    NIH/NIDDK R01DK116064Jan 1, 2018 - Dec 31, 2022
    Role: Co-Principal Investigator
    Developing UPR inhibitory KIRAs into oral antidiabetic beta cell-sparing drugs
    NIH/NIDDK R01DK100623Jan 1, 2014 - Jun 30, 2023
    Role: Principal Investigator
    Attenuating ER and oxidative stress signaling to reduce cell degeneration in vivo
    NIH/NIDDK R01DK095306Aug 1, 2013 - Jul 31, 2017
    Role: Principal Investigator
    Targeting epithelial cells to treat pulmonary fibrosis
    NIH/NHLBI P01HL108794Aug 9, 2012 - Jul 31, 2017
    Role: Co-Investigator
    "Expanding beta-cell mass"
    NIH/NIDDK U01DK089541Sep 15, 2010 - Jun 30, 2015
    Role: Co-Principal Investigator
    Cytoprotection of Beta Cells Through Modulation of Ire1Alpha Function
    NIH/NIDDK R01DK080955Apr 1, 2008 - May 31, 2018
    Role: Principal Investigator
    HTS to discover drugs effecting protein folding in the endoplasmic reticulum
    NIH/NIDDK R21DK080321Mar 1, 2008 - Feb 28, 2010
    Role: Principal Investigator
    New Tools to Measure and Correct Endoplasmic Reticulum Stress in Single Living
    NIH DP2OD001925Sep 30, 2007 - Aug 31, 2012
    Role: Principal Investigator
    Role of the Unfolded Protein Response in Type 2 Diabetes
    NIH/NIDDK K08DK065671Jul 1, 2004 - Jun 30, 2009
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ishibashi T, Morita S, Kishimoto S, Uraki S, Takeshima K, Furukawa Y, Inaba H, Ariyasu H, Iwakura H, Furuta H, Nishi M, Papa FR, Akamizu T. nAChR signaling regulates IRE1a activation to protect ß cells against terminal unfolded protein response under irremediable ER stress. J Diabetes Investig. 2020 Jan 10. PMID: 31925927.
      View in: PubMed
    2. Moore PC, Qi JY, Thamsen M, Ghosh R, Peng J, Gliedt MJ, Meza-Acevedo R, Warren RE, Hiniker A, Kim GE, Maly DJ, Backes BJ, Papa FR, Oakes SA. Parallel Signaling through IRE1a and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival. Cancer Res. 2019 Dec 15; 79(24):6190-6203. PMID: 31672843.
      View in: PubMed
    3. Feldman HC, Vidadala VN, Potter ZE, Papa FR, Backes BJ, Maly DJ. Development of a Chemical Toolset for Studying the Paralog-Specific Function of IRE1. ACS Chem Biol. 2019 Dec 20; 14(12):2595-2605. PMID: 31609569.
      View in: PubMed
    4. Ghosh R, Colon-Negron K, Papa FR. Endoplasmic reticulum stress, degeneration of pancreatic islet ß-cells, and therapeutic modulation of the unfolded protein response in diabetes. Mol Metab. 2019 Sep; 27S:S60-S68. PMID: 31500832.
      View in: PubMed
    5. Gonzalez-Teuber V, Albert-Gasco H, Auyeung VC, Papa FR, Mallucci GR, Hetz C. Small Molecules to Improve ER Proteostasis in Disease. Trends Pharmacol Sci. 2019 Sep; 40(9):684-695. PMID: 31377018.
      View in: PubMed
    6. Igbaria A, Merksamer PI, Trusina A, Tilahun F, Johnson JR, Brandman O, Krogan NJ, Weissman JS, Papa FR. Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress. Proc Natl Acad Sci U S A. 2019 Jun 04; 116(23):11291-11298. PMID: 31101715.
      View in: PubMed
    7. Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR. Small molecule inhibition of IRE1a kinase/RNase has anti-fibrotic effects in the lung. PLoS One. 2019; 14(1):e0209824. PMID: 30625178.
      View in: PubMed
    8. Hetz C, Papa FR. The Unfolded Protein Response and Cell Fate Control. Mol Cell. 2018 01 18; 69(2):169-181. PMID: 29107536.
      View in: PubMed
    9. Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR. Targeting ABL-IRE1a Signaling Spares ER-Stressed Pancreatic ß Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 05 02; 25(5):1207. PMID: 28467938.
      View in: PubMed
    10. Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR. Targeting ABL-IRE1a Signaling Spares ER-Stressed Pancreatic ß Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 Apr 04; 25(4):883-897.e8. PMID: 28380378.
      View in: PubMed
    11. Papa F, Lippolis R, Sardaro N, Gnoni A, Scacco S. All trans retinoic acid depresses the content and activity of the mitochondrial ATP synthase in human keratinocytes. Biochem Biophys Res Commun. 2017 Jan 08; 482(2):301-304. PMID: 27856255.
      View in: PubMed
    12. Feldman HC, Tong M, Wang L, Meza-Acevedo R, Gobillot TA, Lebedev I, Gliedt MJ, Hari SB, Mitra AK, Backes BJ, Papa FR, Seeliger MA, Maly DJ. Structural and Functional Analysis of the Allosteric Inhibition of IRE1a with ATP-Competitive Ligands. ACS Chem Biol. 2016 08 19; 11(8):2195-205. PMID: 27227314.
      View in: PubMed
    13. Valentine CD, Anderson MO, Papa FR, Haggie PM. Correction: X-Box Binding Protein 1 (XBP1s) Is a Critical Determinant of Pseudomonas aeruginosa Homoserine Lactone-Mediated Apoptosis. PLoS Pathog. 2016 May; 12(5):e1005628. PMID: 27191388.
      View in: PubMed
    14. Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, Anderson MS, Liu D, Tang LF, Nicholas SK, Nahmod K, Makedonas G, Canter DL, Kwok PY, Hicks J, Jones KD, Penney S, Jhangiani SN, Rosenblum MD, Dell SD, Waterfield MR, Papa FR, Muzny DM, Zaitlen N, Leal SM, Gonzaga-Jauregui C, Boerwinkle E, Eissa NT, Gibbs RA, Lupski JR, Orange JS, Shum AK. COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. Nat Genet. 2015 Jun; 47(6):654-60. PMID: 25894502.
      View in: PubMed
    15. Maly DJ, Papa FR. Druggable sensors of the unfolded protein response. Nat Chem Biol. 2014 Nov; 10(11):892-901. PMID: 25325700.
      View in: PubMed
    16. Oakes SA, Papa FR. The role of endoplasmic reticulum stress in human pathology. Annu Rev Pathol. 2015; 10:173-94. PMID: 25387057.
      View in: PubMed
    17. Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa FR. Allosteric inhibition of the IRE1a RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 2014 Jul 31; 158(3):534-48. PMID: 25018104.
      View in: PubMed
    18. Sedwick C, Papa F. Feroz Papa: Saving cells from themselves. J Cell Biol. 2014 Mar 03; 204(5):628-9. PMID: 24590168.
      View in: PubMed
    19. Kanekura K, Ishigaki S, Merksamer PI, Papa FR, Urano F. Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells. Lab Invest. 2013 Nov; 93(11):1254-8. PMID: 24042438.
      View in: PubMed
    20. Valentine CD, Anderson MO, Papa FR, Haggie PM. X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis. PLoS Pathog. 2013; 9(8):e1003576. PMID: 23990788.
      View in: PubMed
    21. Cha SI, Ryerson CJ, Lee JS, Kukreja J, Barry SS, Jones KD, Elicker BM, Kim DS, Papa FR, Collard HR, Wolters PJ. Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis. Respir Res. 2012 Nov 20; 13:105. PMID: 23167970.
      View in: PubMed
    22. Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schürer SC, Oakes SA, Papa FR, Maly DJ. Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012 Dec; 8(12):982-9. PMID: 23086298.
      View in: PubMed
    23. Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA. IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science. 2012 Nov 09; 338(6108):818-22. PMID: 23042294.
      View in: PubMed
    24. Papa FR. Endoplasmic reticulum stress, pancreatic ß-cell degeneration, and diabetes. Cold Spring Harb Perspect Med. 2012 Sep 01; 2(9):a007666. PMID: 22951443.
      View in: PubMed
    25. Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR. IRE1a induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab. 2012 Aug 08; 16(2):250-64. PMID: 22883233.
      View in: PubMed
    26. Meares GP, Hughes KJ, Naatz A, Papa FR, Urano F, Hansen PA, Benveniste EN, Corbett JA. IRE1-dependent activation of AMPK in response to nitric oxide. Mol Cell Biol. 2011 Nov; 31(21):4286-97. PMID: 21896783.
      View in: PubMed
    27. Shore GC, Papa FR, Oakes SA. Signaling cell death from the endoplasmic reticulum stress response. Curr Opin Cell Biol. 2011 Apr; 23(2):143-9. PMID: 21146390.
      View in: PubMed
    28. Merksamer PI, Papa FR. The UPR and cell fate at a glance. J Cell Sci. 2010 Apr 01; 123(Pt 7):1003-6. PMID: 20332117.
      View in: PubMed
    29. Lei X, Zhang S, Barbour SE, Bohrer A, Ford EL, Koizumi A, Papa FR, Ramanadham S. Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1. J Biol Chem. 2010 Feb 26; 285(9):6693-705. PMID: 20032468.
      View in: PubMed
    30. Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR. IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell. 2009 Aug 07; 138(3):562-75. PMID: 19665977.
      View in: PubMed
    31. Dan Han, Alana G. Lerner, Lieselotte Vande Walle, John-Paul Upton, Weihong Xu, Andrew Hagen, Bradley J. Backes, Scott A. Oakes, Feroz R. Papa. IRE1a Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates. Journal of End-to-End-testing. 2009 Aug 7; 138(33):562-575.
      View in: Publisher Site
    32. Dan Han, Alana G. Lerner, Lieselotte Vande Walle, John-Paul Upton, Weihong Xu, Andrew Hagen, Bradley J. Backes, Scott A. Oakes, Feroz R. Papa. IRE1a Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates. Journal of End-to-End-testing. 2009 Aug 7; 138(3):562-575.
      View in: Publisher Site
    33. Trusina A, Papa FR, Tang C. Rationalizing translation attenuation in the network architecture of the unfolded protein response. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20280-5. PMID: 19075238.
      View in: PubMed
    34. Merksamer PI, Trusina A, Papa FR. Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions. Cell. 2008 Nov 28; 135(5):933-47. PMID: 19026441.
      View in: PubMed
    35. Upton JP, Austgen K, Nishino M, Coakley KM, Hagen A, Han D, Papa FR, Oakes SA. Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biol. 2008 Jun; 28(12):3943-51. PMID: 18426910.
      View in: PubMed
    36. Ala Trusina, Feroz Papa, Chao Tang. Translation Attenuation Mechanism in Unfolded Protein Response. Evolution from Cellular to Social Scales. 2008 Jan 1; 83-90.
      View in: Publisher Site
    37. Han D, Upton JP, Hagen A, Callahan J, Oakes SA, Papa FR. A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress. Biochem Biophys Res Commun. 2008 Jan 25; 365(4):777-83. PMID: 18035051.
      View in: PubMed
    38. Bernales S, Papa FR, Walter P. Intracellular signaling by the unfolded protein response. Annu Rev Cell Dev Biol. 2006; 22:487-508. PMID: 16822172.
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    39. Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P. On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18773-84. PMID: 16365312.
      View in: PubMed
    40. Papa FR, Zhang C, Shokat K, Walter P. Bypassing a kinase activity with an ATP-competitive drug. Science. 2003 Nov 28; 302(5650):1533-7. PMID: 14564015.
      View in: PubMed
    41. Papa FR, Amerik AY, Hochstrasser M. Interaction of the Doa4 deubiquitinating enzyme with the yeast 26S proteasome. Mol Biol Cell. 1999 Mar; 10(3):741-56. PMID: 10069815.
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    42. Hansen-Hagge TE, Janssen JW, Hameister H, Papa FR, Zechner U, Seriu T, Jauch A, Becke D, Hochstrasser M, Bartram CR. An evolutionarily conserved gene on human chromosome 5q33-q34, UBH1, encodes a novel deubiquitinating enzyme. Genomics. 1998 May 01; 49(3):411-8. PMID: 9615226.
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    43. Zhu Y, Carroll M, Papa FR, Hochstrasser M, D'Andrea AD. DUB-1, a deubiquitinating enzyme with growth-suppressing activity. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3275-9. PMID: 8622927.
      View in: PubMed
    44. DeMarini DJ, Papa FR, Swaminathan S, Ursic D, Rasmussen TP, Culbertson MR, Hochstrasser M. The yeast SEN3 gene encodes a regulatory subunit of the 26S proteasome complex required for ubiquitin-dependent protein degradation in vivo. Mol Cell Biol. 1995 Nov; 15(11):6311-21. PMID: 7565784.
      View in: PubMed
    45. Hochstrasser M, Papa FR, Chen P, Swaminathan S, Johnson P, Stillman L, Amerik AY, Li SJ. The DOA pathway: studies on the functions and mechanisms of ubiquitin-dependent protein degradation in the yeast Saccharomyces cerevisiae. Cold Spring Harb Symp Quant Biol. 1995; 60:503-13. PMID: 8824423.
      View in: PubMed
    46. Papa FR, Hochstrasser M. The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene. Nature. 1993 Nov 25; 366(6453):313-9. PMID: 8247125.
      View in: PubMed
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