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Francesco Boin, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    University of PaduaM.D.1993School of Medicine
    Mayo Clinic Internal Medicine2003School of Medicine
    Johns Hopkins UniversityFellowshipRheumatology

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Stern LK, Selby VN, Kolaitis NA, Boin F, Aras M, Klein L, De Marco T. Heart-lung transplantation: A viable option for connective tissue diseases. Clin Transplant. 2019 Dec 23; e13776. PMID: 31867763.
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    2. Gourh P, Safran SA, Alexander T, Boyden SE, Morgan ND, Shah AA, Mayes MD, Doumatey A, Bentley AR, Shriner D, Domsic RT, Medsger TA, Ramos PS, Silver RM, Steen VD, Varga J, Hsu V, Saketkoo LA, Schiopu E, Khanna D, Gordon JK, Kron B, Criswell LA, Gladue H, Derk CT, Bernstein EJ, Bridges SL, Shanmugam VK, Kolstad KD, Chung L, Kafaja S, Jan R, Trojanowski M, Goldberg A, Korman BD, Steinbach PJ, Chandrasekharappa SC, Mullikin JC, Adeyemo A, Rotimi C, Wigley FM, Kastner DL, Boin F, Remmers EF. HLA and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry. Proc Natl Acad Sci U S A. 2019 Dec 23. PMID: 31871193.
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    3. Kalekar LA, Cohen JN, Prevel N, Sandoval PM, Mathur AN, Moreau JM, Lowe MM, Nosbaum A, Wolters PJ, Haemel A, Boin F, Rosenblum MD. Regulatory T cells in skin are uniquely poised to suppress profibrotic immune responses. Sci Immunol. 2019 Sep 06; 4(39). PMID: 31492709.
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    4. Hinze AM, Lin CT, Hussien AF, Perin J, Venado A, Golden JA, Boin F, Brown RH, Wise RA, Wigley FM. Longitudinal assessment of interstitial lung disease in single lung transplant recipients with scleroderma. Rheumatology (Oxford). 2019 Aug 27. PMID: 31504916.
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    5. Mecoli CA, Talbot CC, Fava A, Cheadle C, Boin F, Wigley FM, Hummers LK. Clinical and Molecular Phenotyping in Scleromyxedema Pre- and Post-Treatment with Intravenous Immunoglobulin. Arthritis Care Res (Hoboken). 2019 Apr 22. PMID: 31008568.
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    6. Gourh P, Remmers EF, Boyden SE, Alexander T, Morgan ND, Shah AA, Mayes MD, Doumatey A, Bentley AR, Shriner D, Domsic RT, Medsger TA, Steen VD, Ramos PS, Silver RM, Korman B, Varga J, Schiopu E, Khanna D, Hsu V, Gordon JK, Saketkoo LA, Gladue H, Kron B, Criswell LA, Derk CT, Bridges SL, Shanmugam VK, Kolstad KD, Chung L, Jan R, Bernstein EJ, Goldberg A, Trojanowski M, Kafaja S, Maksimowicz-McKinnon KM, Mullikin JC, Adeyemo A, Rotimi C, Boin F, Kastner DL, Wigley FM. Brief Report: Whole-Exome Sequencing to Identify Rare Variants and Gene Networks That Increase Susceptibility to Scleroderma in African Americans. Arthritis Rheumatol. 2018 10; 70(10):1654-1660. PMID: 29732714.
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    7. Mecoli CA, Shah AA, Boin F, Wigley FM, Hummers LK. Vascular complications in systemic sclerosis: a prospective cohort study. Clin Rheumatol. 2018 Sep; 37(9):2429-2437. PMID: 29804150.
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    8. Pauling JD, Frech TM, Hughes M, Gordon JK, Domsic RT, Anderson ME, Ingegnoli F, McHugh NJ, Johnson SR, Hudson M, Boin F, Ong VH, Matucci-Cerinic M, Altorok N, Scolnik M, Nikpour M, Shah A, Pope JE, Khanna D, Herrick AL. Patient-reported outcome instruments for assessing Raynaud's phenomenon in systemic sclerosis: A SCTC Vascular Working Group Report. J Scleroderma Relat Disord. 2018 Oct; 3(3):249-252. PMID: 30705970.
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    9. Morgan ND, Shah AA, Mayes MD, Domsic RT, Medsger TA, Steen VD, Varga J, Carns M, Ramos PS, Silver RM, Schiopu E, Khanna D, Hsu V, Gordon JK, Gladue H, Saketkoo LA, Criswell LA, Derk CT, Trojanowski MA, Shanmugam VK, Chung L, Valenzuela A, Jan R, Goldberg A, Remmers EF, Kastner DL, Wigley FM, Gourh P, Boin F. Clinical and serological features of systemic sclerosis in a multicenter African American cohort: Analysis of the genome research in African American scleroderma patients clinical database. Medicine (Baltimore). 2017 Dec; 96(51):e8980. PMID: 29390428.
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    10. Boin F, Giardino Torchia ML, Borrello I, Noonan KA, Neil M, Soloski MJ, Cimbro R. Flow cytometric discrimination of seven lineage markers by using two fluorochromes. PLoS One. 2017; 12(11):e0188916. PMID: 29190813.
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    11. Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P, Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY, Bottini N. PTP4A1 promotes TGFß signaling and fibrosis in systemic sclerosis. Nat Commun. 2017 10 20; 8(1):1060. PMID: 29057934.
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    12. Morisset J, Vittinghoff E, Elicker BM, Hu X, Le S, Ryu JH, Jones KD, Haemel A, Golden JA, Boin F, Ley B, Wolters PJ, King TE, Collard HR, Lee JS. Mortality Risk Prediction in Scleroderma-Related Interstitial Lung Disease: The SADL Model. Chest. 2017 11; 152(5):999-1007. PMID: 28629914.
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    13. Shah RJ, Boin F. Lung Transplantation in Patients With Systemic Sclerosis. Curr Rheumatol Rep. 2017 May; 19(5):23. PMID: 28386760.
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    14. Francesco Boin, Carlo Chizzolini. Inflammation and Immunity. Scleroderma. 2017 Jan 1; 161-195.
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    15. Fredrick M. Wigley, Francesco Boin. Chapter 84 Clinical Features and Treatment of Scleroderma. Kelley and Firestein\u0027s Textbook of Rheumatology. 2017 Jan 1; (J Rheumatol282001):1424-1460.e5.
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    16. Lofgren S, Hinchcliff M, Carns M, Wood T, Aren K, Arroyo E, Cheung P, Kuo A, Valenzuela A, Haemel A, Wolters PJ, Gordon J, Spiera R, Assassi S, Boin F, Chung L, Fiorentino D, Utz PJ, Whitfield ML, Khatri P. Integrated, multicohort analysis of systemic sclerosis identifies robust transcriptional signature of disease severity. JCI Insight. 2016 Dec 22; 1(21):e89073. PMID: 28018971.
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    17. Fava A, Cimbro R, Wigley FM, Liu QR, Rosen A, Boin F. Frequency of circulating topoisomerase-I-specific CD4 T cells predicts presence and progression of interstitial lung disease in scleroderma. Arthritis Res Ther. 2016 05 04; 18(1):99. PMID: 27145754.
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    18. Park JK, Fava A, Carrino J, Del Grande F, Rosen A, Boin F. Association of Acroosteolysis With Enhanced Osteoclastogenesis and Higher Blood Levels of Vascular Endothelial Growth Factor in Systemic Sclerosis. Arthritis Rheumatol. 2016 Jan; 68(1):201-9. PMID: 26361270.
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    19. Paik JJ, Wigley FM, Lloyd TE, Corse AM, Casciola-Rosen L, Shah AA, Boin F, Hummers LK, Mammen AL. Spectrum of Muscle Histopathologic Findings in Forty-Two Scleroderma Patients With Weakness. Arthritis Care Res (Hoboken). 2015 Oct; 67(10):1416-25. PMID: 25989455.
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    20. Huang H, Fava A, Guhr T, Cimbro R, Rosen A, Boin F, Ellis H. A methodology for exploring biomarker--phenotype associations: application to flow cytometry data and systemic sclerosis clinical manifestations. BMC Bioinformatics. 2015 Sep 15; 16:293. PMID: 26373409.
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    21. Chizzolini C, Boin F. The role of the acquired immune response in systemic sclerosis. Semin Immunopathol. 2015 Sep; 37(5):519-28. PMID: 26152639.
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    22. Andrea Fava, Francesco Boin. Historical Perspective of Raynaud’s Phenomenon. Raynaud’s Phenomenon. 2015 Jan 1; 1-11.
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    23. Poelman CL, Hummers LK, Wigley FM, Anderson C, Boin F, Shah AA. Intravenous immunoglobulin may be an effective therapy for refractory, active diffuse cutaneous systemic sclerosis. J Rheumatol. 2015 Feb; 42(2):236-42. PMID: 25433527.
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    24. Boin F, Erre GL, Posadino AM, Cossu A, Giordo R, Spinetti G, Passiu G, Emanueli C, Pintus G. Oxidative stress-dependent activation of collagen synthesis is induced in human pulmonary smooth muscle cells by sera from patients with scleroderma-associated pulmonary hypertension. Orphanet J Rare Dis. 2014 Aug 01; 9:123. PMID: 25085432.
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    25. U. Haque, C. Bingham, T. Guhr, S. Bartlett, S. Ghazarian, F. Boin. AB0086 IL - 17 Levels with Vitamin D Repletion in Rheuamtoid Arthritis. Annals of the Rheumatic Diseases. 2014 Jun 1; 73(Suppl 2):832.
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    26. Joseph CG, Darrah E, Shah AA, Skora AD, Casciola-Rosen LA, Wigley FM, Boin F, Fava A, Thoburn C, Kinde I, Jiao Y, Papadopoulos N, Kinzler KW, Vogelstein B, Rosen A. Association of the autoimmune disease scleroderma with an immunologic response to cancer. Science. 2014 Jan 10; 343(6167):152-7. PMID: 24310608.
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    27. Gelber AC, Manno RL, Shah AA, Woods A, Le EN, Boin F, Hummers LK, Wigley FM. Race and association with disease manifestations and mortality in scleroderma: a 20-year experience at the Johns Hopkins Scleroderma Center and review of the literature. Medicine (Baltimore). 2013 Jul; 92(4):191-205. PMID: 23793108.
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    28. Cottrell TR, Wise RA, Wigley FM, Boin F. The degree of skin involvement identifies distinct lung disease outcomes and survival in systemic sclerosis. Ann Rheum Dis. 2014 Jun; 73(6):1060-6. PMID: 23606705.
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    29. Shah AA, Schiopu E, Hummers LK, Wade M, Phillips K, Anderson C, Wise R, Boin F, Seibold JR, Wigley F, Rollins KD. Open label study of escalating doses of oral treprostinil diethanolamine in patients with systemic sclerosis and digital ischemia: pharmacokinetics and correlation with digital perfusion. Arthritis Res Ther. 2013 Apr 18; 15(2):R54. PMID: 23597147.
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    30. Francesco Boin, Fredrick M. Wigley. 84 Clinical Features and Treatment of Scleroderma. Kelley\u0027s Textbook of Rheumatology. 2013 Jan 1; (Ann Intern Med571962):1366-1403.e4.
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    31. Fava A, Wung PK, Wigley FM, Hummers LK, Daya NR, Ghazarian SR, Boin F. Efficacy of Rho kinase inhibitor fasudil in secondary Raynaud's phenomenon. Arthritis Care Res (Hoboken). 2012 Jun; 64(6):925-9. PMID: 22275160.
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    32. Francesco Boin, Carlo Chizzolini. Immunological Mechanisms. Scleroderma. 2012 Jan 1; 165-189.
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    33. Grader-Beck T, Boin F, von Gunten S, Smith D, Rosen A, Bochner BS. Antibodies recognising sulfated carbohydrates are prevalent in systemic sclerosis and associated with pulmonary vascular disease. Ann Rheum Dis. 2011 Dec; 70(12):2218-24. PMID: 21873333.
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    34. Le EN, Wigley FM, Shah AA, Boin F, Hummers LK. Long-term experience of mycophenolate mofetil for treatment of diffuse cutaneous systemic sclerosis. Ann Rheum Dis. 2011 Jun; 70(6):1104-7. PMID: 21378404.
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    35. Manno R, Boin F. Immunotherapy of systemic sclerosis. Immunotherapy. 2010 Nov; 2(6):863-78. PMID: 21091117.
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    36. Song P, Gocke C, Wigley FM, Boin F. Resolution of pansclerotic morphea after treatment with antithymocyte globulin. Nat Rev Rheumatol. 2009 Sep; 5(9):513-6. PMID: 19710673.
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    37. Sherber NS, Boin F, Hummers LK, Wigley FM. The "tank top sign": a unique pattern of skin fibrosis seen in pansclerotic morphea. Ann Rheum Dis. 2009 Sep; 68(9):1511-2. PMID: 19674989.
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    38. Boin F, Franchini S, Colantuoni E, Rosen A, Wigley FM, Casciola-Rosen L. Independent association of anti-beta(2)-glycoprotein I antibodies with macrovascular disease and mortality in scleroderma patients. Arthritis Rheum. 2009 Aug; 60(8):2480-9. PMID: 19644882.
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    39. Boin F, Wigley F. Connective tissue diseases: Immunosuppressive therapy in SSc: what is the target? Nat Rev Rheumatol. 2009 Jul; 5(7):357-8. PMID: 19568247.
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    40. Loizos N, Lariccia L, Weiner J, Griffith H, Boin F, Hummers L, Wigley F, Kussie P. Lack of detection of agonist activity by antibodies to platelet-derived growth factor receptor alpha in a subset of normal and systemic sclerosis patient sera. Arthritis Rheum. 2009 Apr; 60(4):1145-51. PMID: 19333919.
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    41. Boin F, De Fanis U, Bartlett SJ, Wigley FM, Rosen A, Casolaro V. T cell polarization identifies distinct clinical phenotypes in scleroderma lung disease. Arthritis Rheum. 2008 Apr; 58(4):1165-74. PMID: 18383361.
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    42. Boin F, Hummers LK. Scleroderma-like fibrosing disorders. Rheum Dis Clin North Am. 2008 Feb; 34(1):199-220; ix. PMID: 18329541.
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    43. Boin F, Rosen A. Autoimmunity in systemic sclerosis: current concepts. Curr Rheumatol Rep. 2007 May; 9(2):165-72. PMID: 17502048.
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    44. Boin F, Sciubba JJ, Stone JH. Churg-Strauss syndrome presenting with salivary gland enlargement and respiratory distress. Arthritis Rheum. 2006 Feb 15; 55(1):167-70. PMID: 16463394.
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    45. Boin F, Wigley FM, Schneck JP, Oelke M, Rosen A. Evaluation of topoisomerase-1-specific CD8+ T-cell response in systemic sclerosis. Ann N Y Acad Sci. 2005 Dec; 1062:137-45. PMID: 16461796.
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    46. Boin F, Wigley FM. Understanding, assessing and treating Raynaud's phenomenon. Curr Opin Rheumatol. 2005 Nov; 17(6):752-60. PMID: 16224254.
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    47. Ponti C, Gibellini D, Boin F, Melloni E, Manzoli FA, Cocco L, Zauli G, Vitale M. Role of CREB transcription factor in c-fos activation in natural killer cells. Eur J Immunol. 2002 Dec; 32(12):3358-65. PMID: 12432566.
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    48. Maes M, Bocchio Chiavetto L, Bignotti S, Battisa Tura GJ, Pioli R, Boin F, Kenis G, Bosmans E, de Jongh R, Altamura CA. Increased serum interleukin-8 and interleukin-10 in schizophrenic patients resistant to treatment with neuroleptics and the stimulatory effects of clozapine on serum leukemia inhibitory factor receptor. Schizophr Res. 2002 Apr 01; 54(3):281-91. PMID: 11950553.
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    49. Bocchio Chiavetto L, Boin F, Zanardini R, Popoli M, Michelato A, Bignotti S, Tura GB, Gennarelli M. Association between promoter polymorphic haplotypes of interleukin-10 gene and schizophrenia. Biol Psychiatry. 2002 Mar 15; 51(6):480-4. PMID: 11922883.
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    50. Boin F, Zanardini R, Pioli R, Altamura CA, Maes M, Gennarelli M. Association between -G308A tumor necrosis factor alpha gene polymorphism and schizophrenia. Mol Psychiatry. 2001 Jan; 6(1):79-82. PMID: 11244489.
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    51. R. Zanardini, L. Bocchio Chiavetto, F. Boin, G.B. Tura, S. Bignotti, A. Michelato, M. Popoli, G. Racagni, C.A. Altamura, M. Gennarelli. Association between promoter polymorphic haplotypes of interleukin-10 gene and schizophrenia. European Neuropsychopharmacology. 2001 Jan 1; 11:s298.
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    52. Maes M, Bocchio Chiavetto L, Bignotti S, Battisa Tura G, Pioli R, Boin F, Kenis G, Bosmans E, de Jongh R, Lin A, Racagni G, Altamura CA. Effects of atypical antipsychotics on the inflammatory response system in schizophrenic patients resistant to treatment with typical neuroleptics. Eur Neuropsychopharmacol. 2000 Mar; 10(2):119-24. PMID: 10706993.
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    53. Altamura AC, Boin F, Maes M. HPA axis and cytokines dysregulation in schizophrenia: potential implications for the antipsychotic treatment. Eur Neuropsychopharmacol. 1999 Dec; 10(1):1-4. PMID: 10647089.
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    54. M. Maes, L.Bocchio Chiavetto, S. Bignotti, G.B. Tura, F. Boin, G. Racagni, D. Van West, G. Kenis, E. Bosmans, C.A. Altamura. Effects of atypical antipsychotics on the inflammatory response system In schizophrenic patients resistant to treatment with haloperidol. European Neuropsychopharmacology. 1999 Sep 1; 9:272.
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    55. Ossi E, Bordin MC, Businaro MA, Marson P, Bonadonna P, Chiaramonte M, Boin F, Valenti MT, Fagiolo U. HLA expression in type II mixed cryoglobulinemia and chronic hepatitis C virus. Clin Exp Rheumatol. 1995 Nov-Dec; 13 Suppl 13:S91-3. PMID: 8730485.
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