Frederike Oertel, MD, PhD

Title(s)Postdoctoral Scholar, Neurology
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Charité-Universitätsmedizin Berlin, Berlin, GermanyMD07/2019Medicine
    Charité-Universitätsmedizin Berlin, Berlin, GermanyMD/PhD03/2021Clinical Neuroimmunology
    University of California, San Francisco, San Francisco, CAFellowshipNeuroimmunology
    Collapse Awards and Honors
    NMSS (National Multiple Sclerosis Society)2022Travel Grant
    ACTRIMS2022Travel Grant
    Charité-Universitätsmedizin Berlin2021Robert-Koch-Preis (PhD Award)
    DGN (German Neurology Association)2021Felgenhauer-Forschungspreis ("Felgenhauer Research Award")
    NMSS (National Multiple Sclerosis Society)2021  - 2024Postdoctoral Fellowship
    AAN (American Academy of Neurology)2021  - 2023Neuroscience Research Training Scholarship Award
    Alzheimer's Assocation2021Travel Grant
    ECTRIMS2016  - 2021Travel / Educational Grants (annual)
    Research Day Multiple Sclerosis 2019, Berlin2019Poster Prize
    German National Academic Foundation 2012  - 2019Scholarship
    German Association for Audiology (“DGA”) 2017Publication Award
    Berlin Institute of Health (BIH)2016M.D. Student Research Scholarship
    Berlin Institute of Health (BIH)2016Mobility and Innovation Fund

    Collapse Overview 
    Collapse Overview
    I am a postdoctoral scholar in the Department of Neurology, University of California San Francisco. I completed my M.D. from Charité-Universitätsmedizin Berlin, Germany, the largest university hospital in Europe, and my M.D./Ph.D., for which I was associated with the Clinical Neuroimmunology Department of the Cluster of Excellence NeuroCure at Charité-Universitätsmedizin Berlin.

    Coming from a research background focusing mostly on the development of new diagnostic instruments for multiple sclerosis (MS) and related disorders, I am now planning to strongly endorse my scientific understanding of both basic research and clinical trials in order to foster my future translational career. My major areas of interest are 1.) the understanding of afferent visual system involvement in MS and related disorders, 2.) the utilization of the afferent visual system as the ideal model to clarify structure-function associations and the functional relevance of different disease components and 3.) the development of neuroprotective and regenerative therapies for MS. Especially developing a regenerative therapy for MS patients to improve their functional abilities is my personal goal and it made me want to dedicate my career towards translational MS research. Long-term, I want to help contribute scientifically to a faster diagnostic process and an improved treatment in MS whilst simultaneously becoming the best possible MS specialist for my patients.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reply to "Interpretation of Longitudinal Changes of the Inner Nuclear Layer in MS". Ann Neurol. 2022 Apr 11. Cordano C, Yiu HH, Abdelhak A, Beaudry-Richard A, Oertel FC, Green AJ. PMID: 35403744.
      View in: PubMed   Mentions:
    2. OCT retinal nerve fiber layer thickness differentiates acute optic neuritis from MOG antibody-associated disease and Multiple Sclerosis: RNFL thickening in acute optic neuritis from MOGAD vs MS. Mult Scler Relat Disord. 2022 Feb; 58:103525. Chen JJ, Sotirchos ES, Henderson AD, Vasileiou ES, Flanagan EP, Bhatti MT, Jamali S, Eggenberger ER, Dinome M, Frohman LP, Arnold AC, Bonelli L, Seleme N, Mejia-Vergara AJ, Moss HE, Padungkiatsagul T, Stiebel-Kalish H, Lotan I, Hellmann MA, Hodge D, Oertel FC, Paul F, Saidha S, Calabresi PA, Pittock SJ. PMID: 35038647; PMCID: PMC8882134.
      View in: PubMed   Mentions:
    3. Leveraging Visual Outcome Measures to Advance Therapy Development in Neuroimmunologic Disorders. Neurol Neuroimmunol Neuroinflamm. 2022 03; 9(2). Graves JS, Oertel FC, Van der Walt A, Collorone S, Sotirchos ES, Pihl-Jensen G, Albrecht P, Yeh EA, Saidha S, Frederiksen J, Newsome SD, Paul F, IMSVISUAL. PMID: 34955459; PMCID: PMC8711076.
      View in: PubMed   Mentions:
    4. Astrocytic outer retinal layer thinning is not a feature in AQP4-IgG seropositive neuromyelitis optica spectrum disorders. J Neurol Neurosurg Psychiatry. 2022 02; 93(2):188-195. Lu A, Zimmermann HG, Specovius S, Motamedi S, Chien C, Bereuter C, Lana-Peixoto MA, Fontenelle MA, Ashtari F, Kafieh R, Dehghani A, Pourazizi M, Pandit L, D'Cunha A, Kim HJ, Hyun JW, Jung SK, Leocani L, Pisa M, Radaelli M, Siritho S, May EF, Tongco C, De Sèze J, Senger T, Palace J, Roca-Fernández A, Leite MI, Sharma SM, Stiebel-Kalish H, Asgari N, Soelberg KK, Martinez-Lapiscina EH, Havla J, Mao-Draayer Y, Rimler Z, Reid A, Marignier R, Cobo-Calvo A, Altintas A, Tanriverdi U, Yildirim R, Aktas O, Ringelstein M, Albrecht P, Tavares IM, Bichuetti DB, Jacob A, Huda S, Soto de Castillo I, Petzold A, Green AJ, Yeaman MR, Smith TJ, Cook L, Paul F, Brandt AU, Oertel FC, GJCF International Clinical Consortium for NMOSD. PMID: 34711650; PMCID: PMC8785057.
      View in: PubMed   Mentions:
    5. Retinal Optical Coherence Tomography in Neuromyelitis Optica. Neurol Neuroimmunol Neuroinflamm. 2021 11; 8(6). Oertel FC, Specovius S, Zimmermann HG, Chien C, Motamedi S, Bereuter C, Cook L, Lana Peixoto MA, Fontanelle MA, Kim HJ, Hyun JW, Palace J, Roca-Fernandez A, Leite MI, Sharma S, Ashtari F, Kafieh R, Dehghani A, Pourazizi M, Pandit L, D'Cunha A, Aktas O, Ringelstein M, Albrecht P, May E, Tongco C, Leocani L, Pisa M, Radaelli M, Martinez-Lapiscina EH, Stiebel-Kalish H, Siritho S, de Seze J, Senger T, Havla J, Marignier R, Calvo AC, Bichuetti D, Tavares IM, Asgari N, Soelberg K, Altintas A, Yildirim R, Tanriverdi U, Jacob A, Huda S, Rimler Z, Reid A, Mao-Draayer Y, Soto de Castillo I, Petzold A, Green AJ, Yeaman MR, Smith T, Brandt AU, Paul F, Cobo-Calvo A. PMID: 34526385; PMCID: PMC8448522.
      View in: PubMed   Mentions:    Fields:    
    6. Impaired motion perception is associated with functional and structural visual pathway damage in multiple sclerosis and neuromyelitis optica spectrum disorders. Mult Scler. 2021 Aug 11; 13524585211032801. Ayadi N, Oertel FC, Asseyer S, Rust R, Duchow A, Kuchling J, Bellmann-Strobl J, Ruprecht K, Klistorner A, Brandt AU, Paul F, Zimmermann HG. PMID: 34379018.
      View in: PubMed   Mentions:    Fields:    
    7. Clinical and neuroimaging findings in MOGAD-MRI and OCT. Clin Exp Immunol. 2021 12; 206(3):266-281. Bartels F, Lu A, Oertel FC, Finke C, Paul F, Chien C. PMID: 34152000; PMCID: PMC8561692.
      View in: PubMed   Mentions:    Fields:    
    8. Distinctive waves of innate immune response in the retina in experimental autoimmune encephalomyelitis. JCI Insight. 2021 06 08; 6(11). Cruz-Herranz A, Oertel FC, Kim K, Cantó E, Timmons G, Sin JH, Devereux M, Baker N, Michel B, Schubert RD, Rani L, Cordano C, Baranzini SE, Green AJ. PMID: 34100385; PMCID: PMC8262300.
      View in: PubMed   Mentions: 1     Fields:    
    9. Serum GFAP and NfL as disease severity and prognostic biomarkers in patients with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder. J Neuroinflammation. 2021 May 01; 18(1):105. Schindler P, Grittner U, Oechtering J, Leppert D, Siebert N, Duchow AS, Oertel FC, Asseyer S, Kuchling J, Zimmermann HG, Brandt AU, Benkert P, Reindl M, Jarius S, Paul F, Bellmann-Strobl J, Kuhle J, Ruprecht K. PMID: 33933106; PMCID: PMC8088712.
      View in: PubMed   Mentions: 2     Fields:    
    10. [Differential diagnostics of autoimmune inflammatory spinal cord diseases]. Nervenarzt. 2021 Apr; 92(4):293-306. Oertel FC, Scheel M, Chien C, Bischof A, Finke C, Paul F. PMID: 33765163; PMCID: PMC7992127.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Foveal changes in aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorder are independent of optic neuritis and not overtly progressive. Eur J Neurol. 2021 07; 28(7):2280-2293. Roca-Fernández A, Oertel FC, Yeo T, Motamedi S, Probert F, Craner MJ, Sastre-Garriga J, Zimmermann HG, Asseyer S, Kuchling J, Bellmann-Strobl J, Ruprecht K, Leite MI, Paul F, Brandt AU, Palace J. PMID: 33547839.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. Lateral geniculate nucleus volume changes after optic neuritis in neuromyelitis optica: A longitudinal study. Neuroimage Clin. 2021; 30:102608. Papadopoulou A, Oertel FC, Chien C, Kuchling J, Zimmermann HG, Siebert N, Motamedi S, Souza M, Asseyer S, Bellmann-Strobl J, Ruprecht K, Chakravarty MM, Scheel M, Magon S, Wuerfel J, Paul F, Brandt AU. PMID: 33735786; PMCID: PMC7974320.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. Beneficial effects of autologous mesenchymal stem cell transplantation in active progressive multiple sclerosis. Brain. 2020 12 01; 143(12):3574-3588. Petrou P, Kassis I, Levin N, Paul F, Backner Y, Benoliel T, Oertel FC, Scheel M, Hallimi M, Yaghmour N, Hur TB, Ginzberg A, Levy Y, Abramsky O, Karussis D. PMID: 33253391.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    14. Longitudinal analysis of primary and secondary factors related to fatigue in multiple sclerosis. Acta Neurol Belg. 2021 Feb; 121(1):271-274. Schließeit J, Oertel FC, Cooper G, Brandt AU, Bellmann-Strobl J. PMID: 33185857; PMCID: PMC7937598.
      View in: PubMed   Mentions:    Fields:    
    15. Retinal INL Thickness in Multiple Sclerosis: A Mere Marker of Neurodegeneration? Ann Neurol. 2021 01; 89(1):192-193. Cordano C, Yiu HH, Oertel FC, University of California, San Francisco MS-EPIC Team, Gelfand JM, Hauser SL, Cree BAC, Green AJ. PMID: 33067847; PMCID: PMC7990472.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Cohort profile: a collaborative multicentre study of retinal optical coherence tomography in 539 patients with neuromyelitis optica spectrum disorders (CROCTINO). BMJ Open. 2020 10 29; 10(10):e035397. Specovius S, Zimmermann HG, Oertel FC, Chien C, Bereuter C, Cook LJ, Lana Peixoto MA, Fontenelle MA, Kim HJ, Hyun JW, Jung SK, Palace J, Roca-Fernandez A, Diaz AR, Leite MI, Sharma SM, Ashtari F, Kafieh R, Dehghani A, Pourazizi M, Pandit L, Dcunha A, Aktas O, Ringelstein M, Albrecht P, May E, Tongco C, Leocani L, Pisa M, Radaelli M, Martinez-Lapiscina EH, Stiebel-Kalish H, Hellmann M, Lotan I, Siritho S, de Seze J, Senger T, Havla J, Marignier R, Tilikete C, Cobo Calvo A, Bichuetti DB, Tavares IM, Asgari N, Soelberg K, Altintas A, Yildirim R, Tanriverdi U, Jacob A, Huda S, Rimler Z, Reid A, Mao-Draayer Y, de Castillo IS, Yeaman MR, Smith TJ, Brandt AU, Paul F, GJCF International Clinical Consortium for NMOSD. PMID: 33122310; PMCID: PMC7597491.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Ventral posterior nucleus volume is associated with neuropathic pain intensity in neuromyelitis optica spectrum disorders. Mult Scler Relat Disord. 2020 Nov; 46:102579. Asseyer S, Kuchling J, Gaetano L, Komnenic D, Siebert N, Chien C, Scheel M, Oertel FC, Ruprecht K, Bellmann-Strobl J, Finke C, Chakravarty MM, Magon S, Wuerfel J, Paul F, Papadopoulou A, Brandt AU. PMID: 33296976.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Visual system damage and network maladaptation are associated with cognitive performance in neuromyelitis optica spectrum disorders. Mult Scler Relat Disord. 2020 Oct; 45:102406. Chavarro VS, Bellmann-Strobl J, Zimmermann HG, Scheel M, Chien C, Oertel FC, Weygandt M, Ruprecht K, Paul F, Finke C, Brandt AU. PMID: 32707533.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. Altered fovea in AQP4-IgG-seropositive neuromyelitis optica spectrum disorders. Neurol Neuroimmunol Neuroinflamm. 2020 09; 7(5). Motamedi S, Oertel FC, Yadav SK, Kadas EM, Weise M, Havla J, Ringelstein M, Aktas O, Albrecht P, Ruprecht K, Bellmann-Strobl J, Zimmermann HG, Paul F, Brandt AU. PMID: 32576604; PMCID: PMC7413713.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    20. Functionally Relevant Maculopathy and Optic Atrophy in Spinocerebellar Ataxia Type 1. Mov Disord Clin Pract. 2020 Jul; 7(5):502-508. Oertel FC, Zeitz O, Rönnefarth M, Bereuter C, Motamedi S, Zimmermann HG, Kuchling J, Grosch AS, Doss S, Browne A, Paul F, Schmitz-Hübsch T, Brandt AU. PMID: 32626794; PMCID: PMC7328427.
      View in: PubMed   Mentions: 1  
    21. Optic chiasm measurements may be useful markers of anterior optic pathway degeneration in neuromyelitis optica spectrum disorders. Eur Radiol. 2020 Sep; 30(9):5048-5058. Juenger V, Cooper G, Chien C, Chikermane M, Oertel FC, Zimmermann H, Ruprecht K, Jarius S, Siebert N, Kuchling J, Papadopoulou A, Asseyer S, Bellmann-Strobl J, Paul F, Brandt AU, Scheel M. PMID: 32335748; PMCID: PMC7431438.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    22. Understanding neurodegenerative changes of the afferent visual pathway in MS. Neurol Neuroimmunol Neuroinflamm. 2020 03 05; 7(2). Zimmermann HG, Oertel FC. PMID: 32229640; PMCID: PMC7051199.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Imaging markers of disability in aquaporin-4 immunoglobulin G seropositive neuromyelitis optica: a graph theory study. Brain Commun. 2019; 1(1):fcz026. Chien C, Oertel FC, Siebert N, Zimmermann H, Asseyer S, Kuchling J, Scheel M, Ruprecht K, Bellmann-Strobl J, Paul F, Brandt AU. PMID: 32954267; PMCID: PMC7425339.
      View in: PubMed   Mentions: 1  
    24. Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a longitudinal study. J Neuroinflammation. 2019 Jul 25; 16(1):154. Oertel FC, Outteryck O, Knier B, Zimmermann H, Borisow N, Bellmann-Strobl J, Blaschek A, Jarius S, Reindl M, Ruprecht K, Meinl E, Hohlfeld R, Paul F, Brandt AU, Kümpfel T, Havla J. PMID: 31345223; PMCID: PMC6657100.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    25. Frequency of autoimmune disorders and autoantibodies in European patients with neuromyelitis optica spectrum disorders. Acta Neurol Belg. 2020 Feb; 120(1):223-225. Gkaniatsou T, Papadopoulou A, Paul F, Brandt AU, Oertel FC. PMID: 31264181.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    26. Cognitive Impairment in Neuromyelitis Optica Spectrum Disorders: A Review of Clinical and Neuroradiological Features. Front Neurol. 2019; 10:608. Oertel FC, Schließeit J, Brandt AU, Paul F. PMID: 31258505; PMCID: PMC6587817.
      View in: PubMed   Mentions: 7  
    27. Attack-related damage of thalamic nuclei in neuromyelitis optica spectrum disorders. J Neurol Neurosurg Psychiatry. 2019 10; 90(10):1156-1164. Papadopoulou A, Oertel FC, Gaetano L, Kuchling J, Zimmermann H, Chien C, Siebert N, Asseyer S, Bellmann-Strobl J, Ruprecht K, Chakravarty MM, Scheel M, Magon S, Wuerfel J, Paul F, Brandt AU. PMID: 31127016.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    28. Novel uses of retinal imaging with optical coherence tomography in multiple sclerosis. Expert Rev Neurother. 2019 01; 19(1):31-43. Oertel FC, Zimmermann HG, Brandt AU, Paul F. PMID: 30587061.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    29. [Optical Coherence Tomography in Disorders of the Central Nervous System]. Klin Monbl Augenheilkd. 2018 Nov; 235(11):1242-1258. Papadopoulou A, Oertel FC, Zimmermann H, Zeitz O, Brandt AU, Paul F. PMID: 30458564.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    30. Retinal ganglion cell loss in neuromyelitis optica: a longitudinal study. J Neurol Neurosurg Psychiatry. 2018 12; 89(12):1259-1265. Oertel FC, Havla J, Roca-Fernández A, Lizak N, Zimmermann H, Motamedi S, Borisow N, White OB, Bellmann-Strobl J, Albrecht P, Ruprecht K, Jarius S, Palace J, Leite MI, Kuempfel T, Paul F, Brandt AU. PMID: 29921610.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    31. Comparison of probabilistic tractography and tract-based spatial statistics for assessing optic radiation damage in patients with autoimmune inflammatory disorders of the central nervous system. Neuroimage Clin. 2018; 19:538-550. Kuchling J, Backner Y, Oertel FC, Raz N, Bellmann-Strobl J, Ruprecht K, Paul F, Levin N, Brandt AU, Scheel M. PMID: 29984162; PMCID: PMC6029567.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    32. Association of Visual Impairment in Neuromyelitis Optica Spectrum Disorder With Visual Network Reorganization. JAMA Neurol. 2018 03 01; 75(3):296-303. Finke C, Zimmermann H, Pache F, Oertel FC, Chavarro VS, Kramarenko Y, Bellmann-Strobl J, Ruprecht K, Brandt AU, Paul F. PMID: 29297041; PMCID: PMC5885866.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    33. Retinal optical coherence tomography shows optic disc changes in low intracranial pressure headaches: a case report. Acta Neurol Belg. 2018 Mar; 118(1):131-133. Oertel FC, Bosello F, Petzold A. PMID: 29299774.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Optical coherence tomography in neuromyelitis optica spectrum disorders: potential advantages for individualized monitoring of progression and therapy. EPMA J. 2018 Mar; 9(1):21-33. Oertel FC, Zimmermann H, Paul F, Brandt AU. PMID: 29515685; PMCID: PMC5833887.
      View in: PubMed   Mentions: 26  
    35. [Optical coherence tomography in neuromyelitis optica spectrum disorders]. Nervenarzt. 2017 Dec; 88(12):1411-1420. Oertel FC, Zimmermann H, Brandt AU, Paul F. PMID: 29119196.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    36. CuBe: parametric modeling of 3D foveal shape using cubic Bézier. Biomed Opt Express. 2017 Sep 01; 8(9):4181-4199. Yadav SK, Motamedi S, Oberwahrenbrock T, Oertel FC, Polthier K, Paul F, Kadas EM, Brandt AU. PMID: 28966857; PMCID: PMC5611933.
      View in: PubMed   Mentions: 4  
    37. Contribution of blood vessels to retinal nerve fiber layer thickness in NMOSD. Neurol Neuroimmunol Neuroinflamm. 2017 May; 4(3):e338. Oertel FC, Zimmermann H, Mikolajczak J, Weinhold M, Kadas EM, Oberwahrenbrock T, Pache F, Bellmann-Strobl J, Ruprecht K, Paul F, Brandt AU. PMID: 28451626; PMCID: PMC5398419.
      View in: PubMed   Mentions: 10     Fields:    
    38. Microstructural visual system changes in AQP4-antibody-seropositive NMOSD. Neurol Neuroimmunol Neuroinflamm. 2017 May; 4(3):e334. Oertel FC, Kuchling J, Zimmermann H, Chien C, Schmidt F, Knier B, Bellmann-Strobl J, Korn T, Scheel M, Klistorner A, Ruprecht K, Paul F, Brandt AU. PMID: 28255575; PMCID: PMC5322864.
      View in: PubMed   Mentions: 44     Fields:    
    39. Severe structural and functional visual system damage leads to profound loss of vision-related quality of life in patients with neuromyelitis optica spectrum disorders. Mult Scler Relat Disord. 2017 Jan; 11:45-50. Schmidt F, Zimmermann H, Mikolajczak J, Oertel FC, Pache F, Weinhold M, Schinzel J, Bellmann-Strobl J, Ruprecht K, Paul F, Brandt AU. PMID: 28104256.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    40. MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 4: Afferent visual system damage after optic neuritis in MOG-IgG-seropositive versus AQP4-IgG-seropositive patients. J Neuroinflammation. 2016 11 01; 13(1):282. Pache F, Zimmermann H, Mikolajczak J, Schumacher S, Lacheta A, Oertel FC, Bellmann-Strobl J, Jarius S, Wildemann B, Reindl M, Waldman A, Soelberg K, Asgari N, Ringelstein M, Aktas O, Gross N, Buttmann M, Ach T, Ruprecht K, Paul F, Brandt AU, in cooperation with the Neuromyelitis Optica Study Group (NEMOS). PMID: 27802824; PMCID: PMC5088645.
      View in: PubMed   Mentions: 72     Fields:    Translation:Humans
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