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Gabriele Bergers, PhD

Title(s)Professor, Neurological Surgery
SchoolSchool of Medicine
Phone415-476-6786
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    Collapse Research 
    Collapse Research Activities and Funding
    Inter-regulatory function of immune-modulation and angiogenesis in cancer
    NIH/NCI R01CA201537Aug 1, 2016 - Jul 31, 2021
    Role: Principal Investigator
    Autophagy as a microenvironmental regulator of tumorigenesis and resistance
    NIH/NCI R01CA188404Sep 1, 2014 - Aug 31, 2019
    Role: Co-Principal Investigator
    Biophysical and molecular dialogue of glioma cells and the brain microenvironment
    NIH/NCI U54CA163155Sep 26, 2011 - Jul 31, 2016
    Role: Principal Investigator
    Multipotential mesenchymal stem cell-like cells in pancreatic tumorigenesis
    NIH/NCI R01CA154383Apr 1, 2011 - Mar 31, 2016
    Role: Principal Investigator
    Perivascular Invasion of GBMs
    NIH/NCI R01CA113382Aug 15, 2006 - May 31, 2011
    Role: Principal Investigator
    PDGFRbeta+-Perivascular Cells In Tumor Angiogenesis
    NIH/NCI R01CA109390Aug 1, 2004 - Jul 31, 2009
    Role: Principal Investigator
    Mechanism and therapeutic targeting of evasive resistance to antiangiogenic drugs
    NIH/NCI R01CA099948Feb 11, 2003 - May 31, 2013
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Mazzone M, Bergers G. Regulation of Blood and Lymphatic Vessels by Immune Cells in Tumors and Metastasis. Annu Rev Physiol. 2019 Feb 10; 81:535-560. PMID: 30742781.
      View in: PubMed
    2. Vella G, Bergers G. Where Have All the T Cells Gone? Immunity. 2018 Oct 16; 49(4):592-594. PMID: 30332627.
      View in: PubMed
    3. Barnes JM, Kaushik S, Bainer RO, Sa JK, Woods EC, Kai F, Przybyla L, Lee M, Lee HW, Tung JC, Maller O, Barrett AS, Lu KV, Lakins JN, Hansen KC, Obernier K, Alvarez-Buylla A, Bergers G, Phillips JJ, Nam DH, Bertozzi CR, Weaver VM. A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma. Nat Cell Biol. 2018 Oct; 20(10):1203-1214. PMID: 30202050.
      View in: PubMed
    4. Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW. Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. 2018 Aug; 21(3):425-532. PMID: 29766399.
      View in: PubMed
    5. Missiaen R, Mazzone M, Bergers G. The reciprocal function and regulation of tumor vessels and immune cells offers new therapeutic opportunities in cancer. Semin Cancer Biol. 2018 10; 52(Pt 2):107-116. PMID: 29935312.
      View in: PubMed
    6. He B, Jabouille A, Steri V, Johansson-Percival A, Michael IP, Kotamraju VR, Junckerstorff R, Nowak AK, Hamzah J, Lee G, Bergers G, Ganss R. Vascular targeting of LIGHT normalizes blood vessels in primary brain cancer and induces intratumoural high endothelial venules. J Pathol. 2018 Jun; 245(2):209-221. PMID: 29603739.
      View in: PubMed
    7. Allen E, Missiaen R, Bergers G. Therapeutic induction of high endothelial venules (HEVs) to enhance T-cell infiltration in tumors. Oncotarget. 2017 Nov 21; 8(59):99207-99208. PMID: 29245888.
      View in: PubMed
    8. Jahangiri A, Nguyen A, Chandra A, Sidorov MK, Yagnik G, Rick J, Han SW, Chen W, Flanigan PM, Schneidman-Duhovny D, Mascharak S, De Lay M, Imber B, Park CC, Matsumoto K, Lu K, Bergers G, Sali A, Weiss WA, Aghi MK. Cross-activating c-Met/ß1 integrin complex drives metastasis and invasive resistance in cancer. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):E8685-E8694. PMID: 28973887.
      View in: PubMed
    9. Allen E, Jabouille A, Rivera LB, Lodewijckx I, Missiaen R, Steri V, Feyen K, Tawney J, Hanahan D, Michael IP, Bergers G. Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation. Sci Transl Med. 2017 04 12; 9(385). PMID: 28404866.
      View in: PubMed
    10. Allen E, Missiaen R, Bergers G. Trimming the Vascular Tree in Tumors: Metabolic and Immune Adaptations. Cold Spring Harb Symp Quant Biol. 2016; 81:21-29. PMID: 28396525.
      View in: PubMed
    11. Hambardzumyan D, Bergers G. Glioblastoma: Defining Tumor Niches. Trends Cancer. 2015 Dec; 1(4):252-265. PMID: 27088132.
      View in: PubMed
    12. Rivera LB, Bergers G. CANCER. Tumor angiogenesis, from foe to friend. Science. 2015 Aug 14; 349(6249):694-5. PMID: 26273044.
      View in: PubMed
    13. Rivera LB, Meyronet D, Hervieu V, Frederick MJ, Bergsland E, Bergers G. Intratumoral myeloid cells regulate responsiveness and resistance to antiangiogenic therapy. Cell Rep. 2015 Apr 28; 11(4):577-91. PMID: 25892230; PMCID: PMC4438771.
      View in: PubMed, PubMed Central
    14. Rivera LB, Bergers G. Intertwined regulation of angiogenesis and immunity by myeloid cells. Trends Immunol. 2015 Apr; 36(4):240-9. PMID: 25770923; PMCID: PMC4393787.
      View in: PubMed, PubMed Central
    15. Wang AS, Lodi A, Rivera LB, Izquierdo-Garcia JL, Firpo MA, Mulvihill SJ, Tempero MA, Bergers G, Ronen SM. HR-MAS MRS of the pancreas reveals reduced lipid and elevated lactate and taurine associated with early pancreatic cancer. NMR Biomed. 2014 Nov; 27(11):1361-70. PMID: 25199993.
      View in: PubMed
    16. Rivera LB, Bergers G. Angiogenesis. Targeting vascular sprouts. Science. 2014 Jun 27; 344(6191):1449-50. PMID: 24970064.
      View in: PubMed
    17. Hyvönen M, Enbäck J, Huhtala T, Lammi J, Sihto H, Weisell J, Joensuu H, Rosenthal-Aizman K, El-Andaloussi S, Langel U, Närvänen A, Bergers G, Laakkonen P. Novel target for peptide-based imaging and treatment of brain tumors. Mol Cancer Ther. 2014 Apr; 13(4):996-1007. PMID: 24493698; PMCID: PMC4007056.
      View in: PubMed, PubMed Central
    18. Rivera L, Pandika M, Bergers G. Escape mechanisms from antiangiogenic therapy: an immune cell's perspective. Adv Exp Med Biol. 2014; 772:83-99. PMID: 24272355.
      View in: PubMed
    19. Rivera LB, Bergers G. Location, location, location: macrophage positioning within tumors determines pro- or antitumor activity. Cancer Cell. 2013 Dec 09; 24(6):687-9. PMID: 24332035; PMCID: PMC4243836.
      View in: PubMed, PubMed Central
    20. Jahangiri A, De Lay M, Miller LM, Carbonell WS, Hu YL, Lu K, Tom MW, Paquette J, Tokuyasu TA, Tsao S, Marshall R, Perry A, Bjorgan KM, Chaumeil MM, Ronen SM, Bergers G, Aghi MK. Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance. Clin Cancer Res. 2013 Apr 01; 19(7):1773-83. PMID: 23307858; PMCID: PMC3618605.
      View in: PubMed, PubMed Central
    21. Lu KV, Bergers G. Mechanisms of evasive resistance to anti-VEGF therapy in glioblastoma. CNS Oncol. 2013 Jan; 2(1):49-65. PMID: 23750318; PMCID: PMC3673744.
      View in: PubMed, PubMed Central
    22. Lu KV, Chang JP, Parachoniak CA, Pandika MM, Aghi MK, Meyronet D, Isachenko N, Fouse SD, Phillips JJ, Cheresh DA, Park M, Bergers G. VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex. Cancer Cell. 2012 Jul 10; 22(1):21-35. PMID: 22789536; PMCID: PMC4068350.
      View in: PubMed, PubMed Central
    23. Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J, Phillips J, Siu J, Lim DA, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell. 2011 Sep 13; 20(3):328-40. PMID: 21907924; PMCID: PMC3297490.
      View in: PubMed, PubMed Central
    24. Dvorak HF, Weaver VM, Tlsty TD, Bergers G. Tumor microenvironment and progression. J Surg Oncol. 2011 May 01; 103(6):468-74. PMID: 21480238; PMCID: PMC3277953.
      View in: PubMed, PubMed Central
    25. Persson AI, Petritsch C, Swartling FJ, Itsara M, Sim FJ, Auvergne R, Goldenberg DD, Vandenberg SR, Nguyen KN, Yakovenko S, Ayers-Ringler J, Nishiyama A, Stallcup WB, Berger MS, Bergers G, McKnight TR, Goldman SA, Weiss WA. Non-stem cell origin for oligodendroglioma. Cancer Cell. 2010 Dec 14; 18(6):669-82. PMID: 21156288; PMCID: PMC3031116.
      View in: PubMed, PubMed Central
    26. Lu KV, Zhu S, Cvrljevic A, Huang TT, Sarkaria S, Ahkavan D, Dang J, Dinca EB, Plaisier SB, Oderberg I, Lee Y, Chen Z, Caldwell JS, Xie Y, Loo JA, Seligson D, Chakravari A, Lee FY, Weinmann R, Cloughesy TF, Nelson SF, Bergers G, Graeber T, Furnari FB, James CD, Cavenee WK, Johns TG, Mischel PS. Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients. Cancer Res. 2009 Sep 01; 69(17):6889-98. PMID: 19690143; PMCID: PMC2770839.
      View in: PubMed, PubMed Central
    27. Pàez-Ribes M, Allen E, Hudock J, Takeda T, Okuyama H, Viñals F, Inoue M, Bergers G, Hanahan D, Casanovas O. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell. 2009 Mar 03; 15(3):220-31. PMID: 19249680; PMCID: PMC2874829.
      View in: PubMed, PubMed Central
    28. Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer. 2008 Aug; 8(8):592-603. PMID: 18650835; PMCID: PMC2874834.
      View in: PubMed, PubMed Central
    29. Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008 Jun 24; 6:14. PMID: 18577219; PMCID: PMC2443372.
      View in: PubMed, PubMed Central
    30. Du R, Petritsch C, Lu K, Liu P, Haller A, Ganss R, Song H, Vandenberg S, Bergers G. Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM. Neuro Oncol. 2008 Jun; 10(3):254-64. PMID: 18359864; PMCID: PMC2563048.
      View in: PubMed, PubMed Central
    31. Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, Song H, Vandenberg S, Johnson RS, Werb Z, Bergers G. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 2008 Mar; 13(3):206-20. PMID: 18328425.
      View in: PubMed
    32. Pietras K, Pahler J, Bergers G, Hanahan D. Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting. PLoS Med. 2008 Jan 29; 5(1):e19. PMID: 18232728; PMCID: PMC2214790.
      View in: PubMed, PubMed Central
    33. Lu K, Lamagna C, Bergers G. Chapter 3. Bone marrow-derived vascular progenitors and proangiogenic monocytes in tumors. Methods Enzymol. 2008; 445:53-82. PMID: 19022055.
      View in: PubMed
    34. Chesler L, Goldenberg DD, Seales IT, Satchi-Fainaro R, Grimmer M, Collins R, Struett C, Nguyen KN, Kim G, Tihan T, Bao Y, Brekken RA, Bergers G, Folkman J, Weiss WA. Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma. Cancer Res. 2007 Oct 01; 67(19):9435-42. PMID: 17909053; PMCID: PMC2921769.
      View in: PubMed, PubMed Central
    35. Kawaguchi T, Yamashita Y, Kanamori M, Endersby R, Bankiewicz KS, Baker SJ, Bergers G, Pieper RO. The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo. Cancer Res. 2006 Dec 01; 66(23):11331-40. PMID: 17145879.
      View in: PubMed
    36. Lamagna C, Bergers G. The bone marrow constitutes a reservoir of pericyte progenitors. J Leukoc Biol. 2006 Oct; 80(4):677-81. PMID: 16888086.
      View in: PubMed
    37. Holash J, Thurston G, Rudge JS, Yancopoulos GD, Adjei AA, Bergers G, Pytowski B, Pegram M, Gordon MS. Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agents. Cancer Metastasis Rev. 2006 Jun; 25(2):243-52. PMID: 16770536.
      View in: PubMed
    38. Bergers G, Song S. The role of pericytes in blood-vessel formation and maintenance. Neuro Oncol. 2005 Oct; 7(4):452-64. PMID: 16212810; PMCID: PMC1871727.
      View in: PubMed, PubMed Central
    39. Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell. 2005 Oct; 8(4):299-309. PMID: 16226705.
      View in: PubMed
    40. Song S, Ewald AJ, Stallcup W, Werb Z, Bergers G. PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol. 2005 Sep; 7(9):870-9. PMID: 16113679; PMCID: PMC2771163.
      View in: PubMed, PubMed Central
    41. Berger M, Bergers G, Arnold B, Hämmerling GJ, Ganss R. Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization. Blood. 2005 Feb 01; 105(3):1094-101. PMID: 15459006.
      View in: PubMed
    42. Kanamori M, Vanden Berg SR, Bergers G, Berger MS, Pieper RO. Integrin beta3 overexpression suppresses tumor growth in a human model of gliomagenesis: implications for the role of beta3 overexpression in glioblastoma multiforme. Cancer Res. 2004 Apr 15; 64(8):2751-8. PMID: 15087390.
      View in: PubMed
    43. Joyce JA, Laakkonen P, Bernasconi M, Bergers G, Ruoslahti E, Hanahan D. Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis. Cancer Cell. 2003 Nov; 4(5):393-403. PMID: 14667506.
      View in: PubMed
    44. Blouw B, Song H, Tihan T, Bosze J, Ferrara N, Gerber HP, Johnson RS, Bergers G. The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell. 2003 Aug; 4(2):133-46. PMID: 12957288.
      View in: PubMed
    45. Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 2003 Jun; 3(6):401-10. PMID: 12778130.
      View in: PubMed
    46. Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest. 2003 May; 111(9):1287-95. PMID: 12727920; PMCID: PMC154450.
      View in: PubMed, PubMed Central
    47. Man S, Bocci G, Francia G, Green SK, Jothy S, Hanahan D, Bohlen P, Hicklin DJ, Bergers G, Kerbel RS. Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water. Cancer Res. 2002 May 15; 62(10):2731-5. PMID: 12019144.
      View in: PubMed
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