Gaetano Faleo, PhD

TitleAssociate Specialist
InstitutionUniversity of California San Francisco
Address513 Parnassus Ave
San Francisco CA 94143
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    Collapse Biography 
    Collapse Awards and Honors
    University of Bologna, Italy2002Recipient of European Socrates Fellowship
    University of Bologna, Italy2003Recipient of European Leonardo Fellowship
    University of Foggia, Italy2006Young Investigator Award
    American Transplant Congress2007Recipient of Young Investigator Award
    The Transplantation Society - Cell Transplantation Society2015TTS-CTS Scientific Award

    Collapse Overview 
    Collapse Overview
    I am currently interested in understanding the molecular mechanisms of ischemia causing cell death in islets and stem cell-derived grafts after transplant. My principal aim is to develop biochemical and bioengineering approaches to prevent cell death and prolong graft survival. Successful completion of this work has the potential to dramatically decrease the number of islets required to achieve insulin independence and improve long-term outcome. When combined with stem cell-derived islet transplantation, prevention of islet attrition during peri-transplant period will enable broader clinical use of islet transplantation for diabetic patients. The two manuscripts collecting the most recent data have been published in August 2017.

    I also have a long-standing interest in evaluating effectiveness of immune protection using encapsulation devices. My previous work in this field in collaboration with Viacyte™, led to the first phase 1/2 clinical trial (NCT02239354) initiated in September 2014 to assess safety, tolerability, and efficacy of (VC-01™), a combination product of human stem cell-derived islets encapsulated in Encaptra™ devices to cure type-1 diabetes. Since then, I have used the insights acquired during this pivotal work to develop a novel concept for cell encapsulation in collaboration with the Bioengineering department at UCSF. The manuscript containing the data from this study has been published in June 2016.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Faleo G, Russ HA, Wisel S, Parent AV, Nguyen V, Nair GG, Freise JE, Villanueva KE, Szot GL, Hebrok M, Tang Q. Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant. Stem Cell Reports. 2017 Sep 12; 9(3):807-819. PMID: 28803916.
      View in: PubMed
    2. Chang R, Faleo G, Russ HA, Parent AV, Elledge SK, Bernards DA, Allen JL, Villanueva K, Hebrok M, Tang Q, Desai TA. Nanoporous Immunoprotective Device for Stem-Cell-Derived ß-Cell Replacement Therapy. ACS Nano. 2017 Aug 22; 11(8):7747-7757. PMID: 28763191.
      View in: PubMed
    3. Faleo G, Lee K, Nguyen V, Tang Q. Assessment of Immune Isolation of Allogeneic Mouse Pancreatic Progenitor Cells by a Macroencapsulation Device. Transplantation. 2016 06; 100(6):1211-8. PMID: 26982952; PMCID: PMC4874841 [Available on 06/01/17].
    4. Song S, Faleo G, Yeung R, Kant R, Posselt AM, Desai TA, Tang Q, Roy S. Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport. Sci Rep. 2016 Mar 24; 6:23679. PMID: 27009429.
      View in: PubMed
    5. Nyitray CE, Chang R, Faleo G, Lance KD, Bernards DA, Tang Q, Desai TA. Polycaprolactone Thin-Film Micro- and Nanoporous Cell-Encapsulation Devices. ACS Nano. 2015 Jun 23; 9(6):5675-82. PMID: 25950860; PMCID: PMC4628825.
    6. Faleo G, Berggren PO, Pileggi A. Intravital imaging of cytotoxic T lymphocytes. Methods Mol Biol. 2014; 1186:121-9. PMID: 25149307.
      View in: PubMed
    7. Faleo G, Fotino C, Bocca N, Molano RD, Zahr-Akrawi E, Molina J, Villate S, Umland O, Skyler JS, Bayer AL, Ricordi C, Pileggi A. Prevention of autoimmune diabetes and induction of ß-cell proliferation in NOD mice by hyperbaric oxygen therapy. Diabetes. 2012 Jul; 61(7):1769-78. PMID: 22566533; PMCID: PMC3379675.
    8. Abdulreda MH, Faleo G, Molano RD, Lopez-Cabezas M, Molina J, Tan Y, Echeverria OA, Zahr-Akrawi E, Rodriguez-Diaz R, Edlund PK, Leibiger I, Bayer AL, Perez V, Ricordi C, Caicedo A, Pileggi A, Berggren PO. High-resolution, noninvasive longitudinal live imaging of immune responses. Proc Natl Acad Sci U S A. 2011 Aug 02; 108(31):12863-8. PMID: 21768391; PMCID: PMC3150878.
    9. Yoshida J, Ozaki KS, Nalesnik MA, Ueki S, Castillo-Rama M, Faleo G, Ezzelarab M, Nakao A, Ekser B, Echeverri GJ, Ross MA, Stolz DB, Murase N. Ex vivo application of carbon monoxide in UW solution prevents transplant-induced renal ischemia/reperfusion injury in pigs. Am J Transplant. 2010 Apr; 10(4):763-72. PMID: 20199500; PMCID: PMC2886983.
    10. Nakao A, Faleo G, Nalesnik MA, Seda-Neto J, Kohmoto J, Murase N. Low-dose carbon monoxide inhibits progressive chronic allograft nephropathy and restores renal allograft function. Am J Physiol Renal Physiol. 2009 Jul; 297(1):F19-26. PMID: 19369289; PMCID: PMC2711716.
    11. Nakao A, Faleo G, Shimizu H, Nakahira K, Kohmoto J, Sugimoto R, Choi AM, McCurry KR, Takahashi T, Murase N. Ex vivo carbon monoxide prevents cytochrome P450 degradation and ischemia/reperfusion injury of kidney grafts. Kidney Int. 2008 Oct; 74(8):1009-16. PMID: 18633343.
      View in: PubMed
    12. Faleo G, Neto JS, Kohmoto J, Tomiyama K, Shimizu H, Takahashi T, Wang Y, Sugimoto R, Choi AM, Stolz DB, Carrieri G, McCurry KR, Murase N, Nakao A. Carbon monoxide ameliorates renal cold ischemia-reperfusion injury with an upregulation of vascular endothelial growth factor by activation of hypoxia-inducible factor. Transplantation. 2008 Jun 27; 85(12):1833-40. PMID: 18580478.
      View in: PubMed
    13. Nakao A, Kaczorowski DJ, Zuckerbraun BS, Lei J, Faleo G, Deguchi K, McCurry KR, Billiar TR, Kanno S. Galantamine and carbon monoxide protect brain microvascular endothelial cells by heme oxygenase-1 induction. Biochem Biophys Res Commun. 2008 Mar 14; 367(3):674-9. PMID: 18174021.
      View in: PubMed