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Geoffrey Manley, MD, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentNeurological Surgery
Address185 Berry Street Bldg B
San Francisco CA 94158
Phone415-206-8300
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    Collapse Research 
    Collapse Research Activities and Funding
    Transforming Research and Clinical Knowledge in Traumatic Brain Injury
    NIH/NINDS U01NS086090Sep 30, 2013 - Aug 31, 2018
    Role: Principal Investigator
    Transforming Traumatic Brain Injury Research and Clinical Care
    NIH/NINDS RC2NS069409Sep 30, 2009 - Aug 31, 2013
    Role: Principal Investigator
    Role of Aquaporin-4 Water Channels in Cerebral Edema
    NIH/NINDS R01NS050173May 25, 2005 - Apr 30, 2010
    Role: Principal Investigator
    Vascular Biomechanics in Traumatic Brain Injury
    CDC/NCIPC R49CE000460Sep 1, 2004 - Aug 31, 2008
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gardner RC, Rubenstein R, Wang KKW, Korley FK, Yue JK, Yuh EL, Mukherjee P, Valadka A, Okonkwo DO, Diaz-Arrastia R, Manley G. Age-Related Differences in Diagnostic Accuracy of Plasma GFAP and Tau For Identifying Acute Intracranial Trauma on CT: A TRACK-TBI Study. J Neurotrauma. 2018 May 02. PMID: 29717620.
      View in: PubMed
    2. Korley FK, Yue JK, Wilson D, Hrusovsky K, Diaz-Arrasta R, Ferguson AR, Yuh EL, Mukherjee P, Wang KKW, Valadka A, Puccio A, Okonkwo DO, Manley G. Performance Evaluation of a Multiplex Assay for Simultaneous Detection of Four Clinically Relevant TBI Biomarkers. J Neurotrauma. 2018 Apr 25. PMID: 29690824.
      View in: PubMed
    3. Cnossen MC, van der Naalt J, Spikman JM, Nieboer D, Yue JK, Winkler EA, Manley G, von Steinbuechel N, Polinder S, Steyerberg EW, Lingsma H. Prediction of Persistent Post-Concussion Symptoms Following Mild Traumatic Brain Injury. J Neurotrauma. 2018 Apr 25. PMID: 29690799.
      View in: PubMed
    4. Manley G, Wartini A, Schwabedissen G, Siegl E. Spontaneous otoacoustic emissions in teiid lizards. Hear Res. 2018 Mar 12. PMID: 29551307.
      View in: PubMed
    5. Monson KL, Converse MI, Manley G. Cerebral blood vessel damage in traumatic brain injury. Clin Biomech (Bristol, Avon). 2018 Feb 19. PMID: 29478776.
      View in: PubMed
    6. Gardner RC, Dams-O'Connor K, Morrissey MR, Manley G. Geriatric Traumatic Brain Injury: Epidemiology, Outcomes, Knowledge Gaps, and Future Directions. J Neurotrauma. 2018 Feb 15. PMID: 29212411.
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    7. Machamer J, Temkin N, Manley G, Dikmen S. Functional Status Examination in Patients with Moderate to Severe Traumatic Brain Injuries. J Neurotrauma. 2018 Feb 07. PMID: 29415608.
      View in: PubMed
    8. Davis GA, Ellenbogen RG, Bailes J, Cantu RC, Johnston KM, Manley G, Nagahiro S, Sills A, Tator CH, McCrory P. The Berlin International Consensus Meeting on Concussion in Sport. Neurosurgery. 2018 Feb 01; 82(2):232-236. PMID: 29106653.
      View in: PubMed
    9. Bodien YG, McCrea M, Dikmen S, Temkin N, Boase K, Machamer J, Taylor SR, Sherer M, Levin H, Kramer JH, Corrigan JD, McAllister TW, Whyte J, Manley G, Giacino JT. Optimizing Outcome Assessment in Multicenter TBI Trials: Perspectives From TRACK-TBI and the TBI Endpoints Development Initiative. J Head Trauma Rehabil. 2018 Jan 30. PMID: 29385010.
      View in: PubMed
    10. Wang KK, Yang Z, Zhu T, Shi Y, Rubenstein R, Tyndall JA, Manley G. An update on diagnostic and prognostic biomarkers for traumatic brain injury. Expert Rev Mol Diagn. 2018 Feb; 18(2):165-180. PMID: 29338452.
      View in: PubMed
    11. Nuño T, Denninghoff KR, Pauls Q, Yeatts SD, Silbergleit R, Palesch YY, Merck LH, Manley G, Wright DW. Reply to: Prehospital Intubation: Further Confounders in Trial Results. Prehosp Emerg Care. 2018 Jan 17; 1. PMID: 29338483.
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    12. Maas AIR, Menon DK, Adelson PD, Andelic N, Bell MJ, Belli A, Bragge P, Brazinova A, Büki A, Chesnut RM, Citerio G, Coburn M, Cooper DJ, Crowder AT, Czeiter E, Czosnyka M, Diaz-Arrastia R, Dreier JP, Duhaime AC, Ercole A, van Essen TA, Feigin VL, Gao G, Giacino J, Gonzalez-Lara LE, Gruen RL, Gupta D, Hartings JA, Hill S, Jiang JY, Ketharanathan N, Kompanje EJO, Lanyon L, Laureys S, Lecky F, Levin H, Lingsma HF, Maegele M, Majdan M, Manley G, Marsteller J, Mascia L, McFadyen C, Mondello S, Newcombe V, Palotie A, Parizel PM, Peul W, Piercy J, Polinder S, Puybasset L, Rasmussen TE, Rossaint R, Smielewski P, Söderberg J, Stanworth SJ, Stein MB, von Steinbüchel N, Stewart W, Steyerberg EW, Stocchetti N, Synnot A, Te Ao B, Tenovuo O, Theadom A, Tibboel D, Videtta W, Wang KKW, Williams WH, Wilson L, Yaffe K. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet Neurol. 2017 Dec; 16(12):987-1048. PMID: 29122524.
      View in: PubMed
    13. DiGiorgio AM, Tsolinas R, Alazzeh M, Haefeli J, Talbott JF, Ferguson AR, Bresnahan JC, Beattie MS, Manley G, Whetstone WD, Mummaneni PV, Dhall SS. Safety and effectiveness of early chemical deep venous thrombosis prophylaxis after spinal cord injury: pilot prospective data. Neurosurg Focus. 2017 Nov; 43(5):E21. PMID: 29088948.
      View in: PubMed
    14. Shahjouei S, Sadeghi-Naini M, Yang Z, Kobeissy F, Rathore D, Shokraneh F, Blackburn S, Manley G, Wang KKW. The diagnostic values of UCH-L1 in traumatic brain injury: A meta-analysis. Brain Inj. 2018; 32(1):1-17. PMID: 29087740.
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    15. McCrory P, Meeuwisse W, Dvorak J, Aubry M, Bailes J, Broglio S, Cantu RC, Cassidy D, Echemendia RJ, Castellani RJ, Davis GA, Ellenbogen R, Emery C, Engebretsen L, Feddermann-Demont N, Giza CC, Guskiewicz KM, Herring S, Iverson GL, Johnston KM, Kissick J, Kutcher J, Leddy JJ, Maddocks D, Makdissi M, Manley G, McCrea M, Meehan WP, Nagahiro S, Patricios J, Putukian M, Schneider KJ, Sills A, Tator CH, Turner M, Vos PE. Infographic: Consensus statement on concussion in sport. Br J Sports Med. 2017 Nov; 51(21):1557-1558. PMID: 28899991.
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    16. Rubenstein R, Chang B, Yue JK, Chiu A, Winkler EA, Puccio AM, Diaz-Arrastia R, Yuh EL, Mukherjee P, Valadka AB, Gordon WA, Okonkwo DO, Davies P, Agarwal S, Lin F, Sarkis G, Yadikar H, Yang Z, Manley G, Wang KKW. Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau-Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers. JAMA Neurol. 2017 Sep 01; 74(9):1063-1072. PMID: 28738126.
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    17. Yue JK, Robinson CK, Burke JF, Winkler EA, Deng H, Cnossen MC, Lingsma HF, Ferguson AR, McAllister TW, Rosand J, Burchard EG, Sorani MD, Sharma S, Nielson JL, Satris GG, Talbott JF, Tarapore PE, Korley FK, Wang KKW, Yuh EL, Mukherjee P, Diaz-Arrastia R, Valadka AB, Okonkwo DO, Manley G. Apolipoprotein E epsilon 4 (APOE-e4) genotype is associated with decreased 6-month verbal memory performance after mild traumatic brain injury. Brain Behav. 2017 Sep; 7(9):e00791. PMID: 28948085.
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    18. Yue JK, Ngwenya LB, Upadhyayula PS, Deng H, Winkler EA, Burke JF, Lee YM, Robinson CK, Ferguson AR, Lingsma HF, Cnossen MC, Pirracchio R, Korley FK, Vassar MJ, Yuh EL, Mukherjee P, Gordon WA, Valadka AB, Okonkwo DO, Manley G. Emergency department blood alcohol level associates with injury factors and six-month outcome after uncomplicated mild traumatic brain injury. J Clin Neurosci. 2017 Nov; 45:293-298. PMID: 28789959.
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    19. Yue JK, Burke JF, Upadhyayula PS, Winkler EA, Deng H, Robinson CK, Pirracchio R, Suen CG, Sharma S, Ferguson AR, Ngwenya LB, Stein MB, Manley G, Tarapore PE. Selective Serotonin Reuptake Inhibitors for Treating Neurocognitive and Neuropsychiatric Disorders Following Traumatic Brain Injury: An Evaluation of Current Evidence. Brain Sci. 2017 Jul 25; 7(8). PMID: 28757598.
      View in: PubMed
    20. Dhall SS, Haefeli J, Talbott JF, Ferguson AR, Readdy WJ, Bresnahan JC, Beattie MS, Pan JZ, Manley G, Whetstone WD. Motor Evoked Potentials Correlate With Magnetic Resonance Imaging and Early Recovery After Acute Spinal Cord Injury. Neurosurgery. 2017 Jul 07. PMID: 28973360.
      View in: PubMed
    21. Ngwenya LB, Suen CG, Tarapore PE, Manley G, Huang MC. Safety and cost efficiency of a restrictive transfusion protocol in patients with traumatic brain injury. J Neurosurg. 2018 May; 128(5):1530-1537. PMID: 28644101.
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    22. Nelson LD, Ranson J, Ferguson AR, Giacino J, Okonkwo DO, Valadka A, Manley G, McCrea M. Validating Multidimensional Outcome Assessment Using the TBI Common Data Elements: An Analysis of the TRACK-TBI Pilot Sample. J Neurotrauma. 2017 Jun 08. PMID: 28595478.
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    23. Dhall SS, Yue JK, Winkler EA, Mummaneni PV, Manley G, Tarapore PE. Morbidity and Mortality Associated with Surgery of Traumatic C2 Fractures in Octogenarians. Neurosurgery. 2017 Jun 01; 80(6):854-862. PMID: 28368543.
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    24. Denninghoff KR, Nuño T, Pauls Q, Yeatts SD, Silbergleit R, Palesch YY, Merck LH, Manley G, Wright DW. Prehospital Intubation is Associated with Favorable Outcomes and Lower Mortality in ProTECT III. Prehosp Emerg Care. 2017 Sep-Oct; 21(5):539-544. PMID: 28489506.
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    25. Manley G, MacDonald CL, Markowitz A, Stephenson D, Robbins A, Gardner RC, Winkler EA, Bodien Y, Taylor S, Yue JK, Kannan L, Kumar A, McCrea M, Wang KKW. The Traumatic Brain Injury Endpoints Development (TED) Initiative: Progress on a Public-Private Regulatory Collaboration to Accelerate Diagnosis and Treatment of Traumatic Brain Injury. J Neurotrauma. 2017 Mar 31. PMID: 28363253.
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    26. Cnossen MC, Winkler EA, Yue JK, Okonkwo DO, Valadka A, Steyerberg EW, Lingsma H, Manley G. Development of a Prediction Model for Post-Concussive Symptoms following Mild Traumatic Brain Injury: A TRACK-TBI Pilot Study. J Neurotrauma. 2017 Mar 27. PMID: 28343409.
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    27. Nielson JL, Cooper SR, Yue JK, Sorani MD, Inoue T, Yuh EL, Mukherjee P, Petrossian TC, Paquette J, Lum PY, Carlsson GE, Vassar MJ, Lingsma HF, Gordon WA, Valadka AB, Okonkwo DO, Manley G, Ferguson AR. Uncovering precision phenotype-biomarker associations in traumatic brain injury using topological data analysis. PLoS One. 2017; 12(3):e0169490. PMID: 28257413.
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    28. Palacios EM, Yuh EL, Chang YS, Yue JK, Schnyer DM, Okonkwo DO, Valadka AB, Gordon WA, Maas AIR, Vassar M, Manley G, Mukherjee P. Resting-State Functional Connectivity Alterations Associated with Six-Month Outcomes in Mild Traumatic Brain Injury. J Neurotrauma. 2017 04 15; 34(8):1546-1557. PMID: 28085565.
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    29. Yue JK, Winkler EA, Sharma S, Vassar MJ, Ratcliff JJ, Korley FK, Seabury SA, Ferguson AR, Lingsma HF, Meeuws S, Adeoye OM, Rick JW, Robinson CK, Duarte SM, Yuh EL, Mukherjee P, Dikmen SS, McAllister TW, Diaz-Arrastia R, Valadka AB, Gordon WA, Okonkwo DO, Manley G. Temporal profile of care following mild traumatic brain injury: predictors of hospital admission, follow-up referral and six-month outcome. Brain Inj. 2017; 31(13-14):1820-1829. PMID: 29166203.
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    30. Manley G. The mammalian Cretaceous cochlear revolution. Hear Res. 2017 Sep; 352:23-29. PMID: 28007525.
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    31. Collins MW, Kontos AP, Okonkwo DO, Almquist J, Bailes J, Barisa M, Bazarian J, Bloom OJ, Brody DL, Cantu R, Cardenas J, Clugston J, Cohen R, Echemendia R, Elbin RJ, Ellenbogen R, Fonseca J, Gioia G, Guskiewicz K, Heyer R, Hotz G, Iverson GL, Jordan B, Manley G, Maroon J, McAllister T, McCrea M, Mucha A, Pieroth E, Podell K, Pombo M, Shetty T, Sills A, Solomon G, Thomas DG, Valovich McLeod TC, Yates T, Zafonte R. Statements of Agreement From the Targeted Evaluation and Active Management (TEAM) Approaches to Treating Concussion Meeting Held in Pittsburgh, October 15-16, 2015. Neurosurgery. 2016 12; 79(6):912-929. PMID: 27741219.
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    32. Yue JK, Winkler EA, Rick JW, Burke JF, McAllister TW, Oh SS, Burchard EG, Hu D, Rosand J, Temkin NR, Korley FK, Sorani MD, Ferguson AR, Lingsma HF, Sharma S, Robinson CK, Yuh EL, Tarapore PE, Wang KK, Puccio AM, Mukherjee P, Diaz-Arrastia R, Gordon WA, Valadka AB, Okonkwo DO, Manley G. DRD2 C957T polymorphism is associated with improved 6-month verbal learning following traumatic brain injury. Neurogenetics. 2017 01; 18(1):29-38. PMID: 27826691.
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    33. Readdy WJ, Saigal R, Whetstone WD, Mefford AN, Ferguson AR, Talbott JF, Inoue T, Bresnahan JC, Beattie MS, Pan J, Manley G, Dhall SS. Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury. Neurosurgery. 2016 Nov; 79(5):708-714. PMID: 27759678.
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    34. Winkler EA, Yue JK, Ferguson AR, Temkin NR, Stein MB, Barber J, Yuh EL, Sharma S, Satris GG, McAllister TW, Rosand J, Sorani MD, Lingsma HF, Tarapore PE, Burchard EG, Hu D, Eng C, Wang KK, Mukherjee P, Okonkwo DO, Diaz-Arrastia R, Manley G. COMT Val158Met polymorphism is associated with post-traumatic stress disorder and functional outcome following mild traumatic brain injury. J Clin Neurosci. 2017 Jan; 35:109-116. PMID: 27769642.
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    35. Vespa PM, Hirt D, Manley G. Advances in Neurotrauma Research. Neurosurg Clin N Am. 2016 Oct; 27(4):xv-xvi. PMID: 27637404.
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    36. Winkler EA, Minter D, Yue JK, Manley G. Cerebral Edema in Traumatic Brain Injury: Pathophysiology and Prospective Therapeutic Targets. Neurosurg Clin N Am. 2016 Oct; 27(4):473-88. PMID: 27637397.
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    37. Catapano JS, John Hawryluk GW, Whetstone W, Saigal R, Ferguson A, Talbott J, Bresnahan J, Dhall S, Pan J, Beattie M, Manley G. Higher Mean Arterial Pressure Values Correlate with Neurologic Improvement in Patients with Initially Complete Spinal Cord Injuries. World Neurosurg. 2016 Dec; 96:72-79. PMID: 27565460.
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    38. Manley G. Comparative Auditory Neuroscience: Understanding the Evolution and Function of Ears. J Assoc Res Otolaryngol. 2017 Feb; 18(1):1-24. PMID: 27539715.
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    39. Ngwenya LB, Burke JF, Manley G. Brain Tissue Oxygen Monitoring and the Intersection of Brain and Lung: A Comprehensive Review. Respir Care. 2016 Sep; 61(9):1232-44. PMID: 27435860.
      View in: PubMed
    40. Pirracchio R, Yue JK, Manley G, van der Laan MJ, Hubbard AE. Collaborative targeted maximum likelihood estimation for variable importance measure: Illustration for functional outcome prediction in mild traumatic brain injuries. Stat Methods Med Res. 2018 Jan; 27(1):286-297. PMID: 27363429.
      View in: PubMed
    41. Silverberg ND, Crane PK, Dams-O'Connor K, Holdnack J, Ivins BJ, Lange RT, Manley G, McCrea M, Iverson GL. Developing a Cognition Endpoint for Traumatic Brain Injury Clinical Trials. J Neurotrauma. 2017 Jan 15; 34(2):363-371. PMID: 27188248.
      View in: PubMed
    42. Haarbauer-Krupa J, Taylor CA, Yue JK, Winkler EA, Pirracchio R, Cooper SR, Burke JF, Stein MB, Manley G. Screening for Post-Traumatic Stress Disorder in a Civilian Emergency Department Population with Traumatic Brain Injury. J Neurotrauma. 2017 Jan 01; 34(1):50-58. PMID: 26936513.
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    43. Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley G, Matthay MA, Calfee CS, Cohen MJ. The acute respiratory distress syndrome following isolated severe traumatic brain injury. J Trauma Acute Care Surg. 2016 06; 80(6):989-97. PMID: 26881489.
      View in: PubMed
    44. Manley G, van Dijk P. Frequency selectivity of the human cochlea: Suppression tuning of spontaneous otoacoustic emissions. Hear Res. 2016 06; 336:53-62. PMID: 27139323.
      View in: PubMed
    45. Tarapore PE, Vassar MJ, Cooper S, Lay T, Galletly J, Manley G, Huang MC. Establishing a Traumatic Brain Injury Program of Care: Benchmarking Outcomes after Institutional Adoption of Evidence-Based Guidelines. J Neurotrauma. 2016 Nov 15; 33(22):2026-2033. PMID: 26917004.
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    46. Lee S, Mattingly A, Lin A, Sacramento J, Mannent L, Castel MN, Canolle B, Delbary-Gossart S, Ferzaz B, Morganti JM, Rosi S, Ferguson AR, Manley G, Bresnahan JC, Beattie MS. A novel antagonist of p75NTR reduces peripheral expansion and CNS trafficking of pro-inflammatory monocytes and spares function after traumatic brain injury. J Neuroinflammation. 2016 Apr 22; 13(1):88. PMID: 27102880; PMCID: PMC4840857.
    47. Delbary-Gossart S, Lee S, Baroni M, Lamarche I, Arnone M, Canolle B, Lin A, Sacramento J, Salegio EA, Castel MN, Delesque-Touchard N, Alam A, Laboudie P, Ferzaz B, Savi P, Herbert JM, Manley G, Ferguson AR, Bresnahan JC, Bono F, Beattie MS. A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury. Brain. 2016 06; 139(Pt 6):1762-82. PMID: 27084575; PMCID: PMC4892754.
    48. Winkler EA, Yue JK, Burke JF, Chan AK, Dhall SS, Berger MS, Manley G, Tarapore PE. Adult sports-related traumatic brain injury in United States trauma centers. Neurosurg Focus. 2016 Apr; 40(4):E4. PMID: 27032921.
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    49. Yue JK, Winkler EA, Burke JF, Chan AK, Dhall SS, Berger MS, Manley G, Tarapore PE. Pediatric sports-related traumatic brain injury in United States trauma centers. Neurosurg Focus. 2016 Apr; 40(4):E3. PMID: 27032920.
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    50. Hawryluk GW, Phan N, Ferguson AR, Morabito D, Derugin N, Stewart CL, Knudson MM, Manley G, Rosenthal G. Brain tissue oxygen tension and its response to physiological manipulations: influence of distance from injury site in a swine model of traumatic brain injury. J Neurosurg. 2016 Nov; 125(5):1217-1228. PMID: 26848909.
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    51. Wang KK, Yang Z, Yue JK, Zhang Z, Winkler EA, Puccio AM, Diaz-Arrastia R, Lingsma HF, Yuh EL, Mukherjee P, Valadka AB, Gordon WA, Okonkwo DO, Manley G, Cooper SR, Dams-O'Connor K, Hricik AJ, Inoue T, Maas AI, Menon DK, Schnyer DM, Sinha TK, Vassar MJ. Plasma Anti-Glial Fibrillary Acidic Protein Autoantibody Levels during the Acute and Chronic Phases of Traumatic Brain Injury: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot Study. J Neurotrauma. 2016 Jul 01; 33(13):1270-7. PMID: 26560343; PMCID: PMC4931336 [Available on 07/01/17].
    52. Mabray MC, Talbott JF, Whetstone WD, Dhall SS, Phillips DB, Pan JZ, Manley G, Bresnahan JC, Beattie MS, Haefeli J, Ferguson AR. Multidimensional Analysis of Magnetic Resonance Imaging Predicts Early Impairment in Thoracic and Thoracolumbar Spinal Cord Injury. J Neurotrauma. 2016 05 15; 33(10):954-62. PMID: 26414451; PMCID: PMC4876497 [Available on 05/15/17].
    53. Winkler EA, Yue JK, McAllister TW, Temkin NR, Oh SS, Burchard EG, Hu D, Ferguson AR, Lingsma HF, Burke JF, Sorani MD, Rosand J, Yuh EL, Barber J, Tarapore PE, Gardner RC, Sharma S, Satris GG, Eng C, Puccio AM, Wang KK, Mukherjee P, Valadka AB, Okonkwo DO, Diaz-Arrastia R, Manley G. COMT Val 158 Met polymorphism is associated with nonverbal cognition following mild traumatic brain injury. Neurogenetics. 2016 Jan; 17(1):31-41. PMID: 26576546; PMCID: PMC4988810 [Available on 01/01/17].
    54. Nielson JL, Paquette J, Liu AW, Guandique CF, Tovar CA, Inoue T, Irvine KA, Gensel JC, Kloke J, Petrossian TC, Lum PY, Carlsson GE, Manley G, Young W, Beattie MS, Bresnahan JC, Ferguson AR. Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury. Nat Commun. 2015 Oct 14; 6:8581. PMID: 26466022; PMCID: PMC4634208.
    55. Winkler EA, Yue JK, Birk H, Robinson CK, Manley G, Dhall SS, Tarapore PE. Perioperative morbidity and mortality after lumbar trauma in the elderly. Neurosurg Focus. 2015 Oct; 39(4):E2. PMID: 26424342.
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    56. Amyot F, Arciniegas DB, Brazaitis MP, Curley KC, Diaz-Arrastia R, Gandjbakhche A, Herscovitch P, Hinds SR, Manley G, Pacifico A, Razumovsky A, Riley J, Salzer W, Shih R, Smirniotopoulos JG, Stocker D. A Review of the Effectiveness of Neuroimaging Modalities for the Detection of Traumatic Brain Injury. J Neurotrauma. 2015 Nov 15; 32(22):1693-721. PMID: 26176603; PMCID: PMC4651019 [Available on 11/15/16].
    57. Korley FK, Diaz-Arrastia R, Wu AH, Yue JK, Manley G, Sair HI, Van Eyk J, Everett AD. Circulating Brain-Derived Neurotrophic Factor Has Diagnostic and Prognostic Value in Traumatic Brain Injury. J Neurotrauma. 2016 Jan 15; 33(2):215-25. PMID: 26159676; PMCID: PMC4722554 [Available on 01/15/17].
    58. Hawryluk G, Whetstone W, Saigal R, Ferguson A, Talbott J, Bresnahan J, Dhall S, Pan J, Beattie M, Manley G. Mean Arterial Blood Pressure Correlates with Neurological Recovery after Human Spinal Cord Injury: Analysis of High Frequency Physiologic Data. J Neurotrauma. 2015 Dec 15; 32(24):1958-67. PMID: 25669633.
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    59. Readdy WJ, Whetstone WD, Ferguson AR, Talbott JF, Inoue T, Saigal R, Bresnahan JC, Beattie MS, Pan JZ, Manley G, Dhall SS. Complications and outcomes of vasopressor usage in acute traumatic central cord syndrome. J Neurosurg Spine. 2015 Jul 31; 1-7. PMID: 26230417.
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    60. Talbott JF, Whetstone WD, Readdy WJ, Ferguson AR, Bresnahan JC, Saigal R, Hawryluk GW, Beattie MS, Mabray MC, Pan JZ, Manley G, Dhall SS. The Brain and Spinal Injury Center score: a novel, simple, and reproducible method for assessing the severity of acute cervical spinal cord injury with axial T2-weighted MRI findings. J Neurosurg Spine. 2015 Oct; 23(4):495-504. PMID: 26161519.
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    61. Yao X, Uchida K, Papadopoulos MC, Zador Z, Manley G, Verkman AS. Mildly Reduced Brain Swelling and Improved Neurological Outcome in Aquaporin-4 Knockout Mice following Controlled Cortical Impact Brain Injury. J Neurotrauma. 2015 Oct 01; 32(19):1458-64. PMID: 25790314; PMCID: PMC4589265 [Available on 10/01/16].
    62. Yao X, Smith AJ, Jin BJ, Zador Z, Manley G, Verkman AS. Aquaporin-4 regulates the velocity and frequency of cortical spreading depression in mice. Glia. 2015 Oct; 63(10):1860-9. PMID: 25944186; PMCID: PMC4743984 [Available on 10/01/16].
    63. Yue JK, Pronger AM, Ferguson AR, Temkin NR, Sharma S, Rosand J, Sorani MD, McAllister TW, Barber J, Winkler EA, Burchard EG, Hu D, Lingsma HF, Cooper SR, Puccio AM, Okonkwo DO, Diaz-Arrastia R, Manley G. Association of a common genetic variant within ANKK1 with six-month cognitive performance after traumatic brain injury. Neurogenetics. 2015 Jul; 16(3):169-80. PMID: 25633559.
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    64. McMahon PJ, Panczykowski DM, Yue JK, Puccio AM, Inoue T, Sorani MD, Lingsma HF, Maas AI, Valadka AB, Yuh EL, Mukherjee P, Manley G, Okonkwo DO. Measurement of the glial fibrillary acidic protein and its breakdown products GFAP-BDP biomarker for the detection of traumatic brain injury compared to computed tomography and magnetic resonance imaging. J Neurotrauma. 2015 Apr 15; 32(8):527-33. PMID: 25264814; PMCID: PMC4394160.
    65. Sorani MD, Yue JK, Sharma S, Manley G, Ferguson AR. Genetic data sharing and privacy. Neuroinformatics. 2015 Jan; 13(1):1-6. PMID: 25326433.
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    66. Maas AI, Menon DK, Steyerberg EW, Citerio G, Lecky F, Manley G, Hill S, Legrand V, Sorgner A. Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study. Neurosurgery. 2015 Jan; 76(1):67-80. PMID: 25525693.
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    67. Hawryluk GW, Manley G. Classification of traumatic brain injury: past, present, and future. Handb Clin Neurol. 2015; 127:15-21. PMID: 25702207.
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    68. Wright DW, Yeatts SD, Silbergleit R, Palesch YY, Hertzberg VS, Frankel M, Goldstein FC, Caveney AF, Howlett-Smith H, Bengelink EM, Manley G, Merck LH, Janis LS, Barsan WG. Very early administration of progesterone for acute traumatic brain injury. N Engl J Med. 2014 Dec 25; 371(26):2457-66. PMID: 25493974; PMCID: PMC4303469.
    69. Lingsma HF, Yue JK, Maas AI, Steyerberg EW, Manley G. Outcome prediction after mild and complicated mild traumatic brain injury: external validation of existing models and identification of new predictors using the TRACK-TBI pilot study. J Neurotrauma. 2015 Jan 15; 32(2):83-94. PMID: 25025611; PMCID: PMC4291219.
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    87. Weiner MW, Friedl KE, Pacifico A, Chapman JC, Jaffee MS, Little DM, Manley G, McKee A, Petersen RC, Pitman RK, Yaffe K, Zetterberg H, Obana R, Bain LJ, Carrillo MC. Military risk factors for Alzheimer's disease. Alzheimers Dement. 2013 Jul; 9(4):445-51. PMID: 23809365.
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    117. Grossman AD, Cohen MJ, Manley G, Butte AJ. Infection in the intensive care unit alters physiological networks. BMC Bioinformatics. 2009 Sep 17; 10 Suppl 9:S4. PMID: 19761574; PMCID: PMC2745691.
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    171. Auguste KI, Jin S, Uchida K, Yan D, Manley G, Papadopoulos MC, Verkman AS. Greatly impaired migration of implanted aquaporin-4-deficient astroglial cells in mouse brain toward a site of injury. FASEB J. 2007 Jan; 21(1):108-16. PMID: 17135365.
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    172. Chi JH, Knudson MM, Vassar MJ, McCarthy MC, Shapiro MB, Mallet S, Holcroft JJ, Moncrief H, Noble J, Wisner D, Kaups KL, Bennick LD, Manley G. Prehospital hypoxia affects outcome in patients with traumatic brain injury: a prospective multicenter study. J Trauma. 2006 Nov; 61(5):1134-41. PMID: 17099519.
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    173. Ikossi DG, Knudson MM, Morabito DJ, Cohen MJ, Wan JJ, Khaw L, Stewart CJ, Hemphill C, Manley G. Continuous muscle tissue oxygenation in critically injured patients: a prospective observational study. J Trauma. 2006 Oct; 61(4):780-8; discussion 788-90. PMID: 17033541.
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    174. Binder DK, Yao X, Zador Z, Sick TJ, Verkman AS, Manley G. Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels. Glia. 2006 Apr 15; 53(6):631-6. PMID: 16470808.
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    175. Bloch O, Auguste KI, Manley G, Verkman AS. Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice. J Cereb Blood Flow Metab. 2006 Dec; 26(12):1527-37. PMID: 16552421.
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    176. Manley G, Rosenthal G, Lam M, Morabito D, Yan D, Derugin N, Bollen A, Knudson MM, Panter SS. Controlled cortical impact in swine: pathophysiology and biomechanics. J Neurotrauma. 2006 Feb; 23(2):128-39. PMID: 16503797.
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    177. Oshio K, Watanabe H, Yan D, Verkman AS, Manley G. Impaired pain sensation in mice lacking Aquaporin-1 water channels. Biochem Biophys Res Commun. 2006 Mar 24; 341(4):1022-8. PMID: 16476579.
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    178. Livingston DH, Lavery RF, Mosenthal AC, Knudson MM, Lee S, Morabito D, Manley G, Nathens A, Jurkovich G, Hoyt DB, Coimbra R. Recovery at one year following isolated traumatic brain injury: a Western Trauma Association prospective multicenter trial. J Trauma. 2005 Dec; 59(6):1298-304; discussion 1304. PMID: 16394900.
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    179. Saadoun S, Papadopoulos MC, Watanabe H, Yan D, Manley G, Verkman AS. Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J Cell Sci. 2005 Dec 15; 118(Pt 24):5691-8. PMID: 16303850.
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    180. Padmawar P, Yao X, Bloch O, Manley G, Verkman AS. K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator. Nat Methods. 2005 Nov; 2(11):825-7. PMID: 16278651.
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    181. Bloch O, Papadopoulos MC, Manley G, Verkman AS. Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess. J Neurochem. 2005 Oct; 95(1):254-62. PMID: 16181429.
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    182. Ware ML, Nemani VM, Meeker M, Lee C, Morabito DJ, Manley G. Effects of 23.4% sodium chloride solution in reducing intracranial pressure in patients with traumatic brain injury: a preliminary study. Neurosurgery. 2005 Oct; 57(4):727-36; discussion 727-36. PMID: 16239885.
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    183. Chi JH, Manley G, Chou D. Pregnancy-related vertebral hemangioma. Case report, review of the literature, and management algorithm. Neurosurg Focus. 2005 Sep 15; 19(3):E7. PMID: 16190606.
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    184. Quiñones-Hinojosa A, Jun P, Manley G, Knudson MM, Gupta N. Airbag deployment and improperly restrained children: a lethal combination. J Trauma. 2005 Sep; 59(3):729-33. PMID: 16361920.
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    185. Du R, Meeker M, Bacchetti P, Larson MD, Holland MC, Manley G. Evaluation of the portable infrared pupillometer. Neurosurgery. 2005 Jul; 57(1):198-203; discussion 198-203. PMID: 15987563.
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    186. Hemphill JC, Smith WS, Sonne DC, Morabito D, Manley G. Relationship between brain tissue oxygen tension and CT perfusion: feasibility and initial results. AJNR Am J Neuroradiol. 2005 May; 26(5):1095-100. PMID: 15891166.
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    187. Hemphill JC, Barton CW, Morabito D, Manley G. Influence of data resolution and interpolation method on assessment of secondary brain insults in neurocritical care. Physiol Meas. 2005 Aug; 26(4):373-86. PMID: 15886433.
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    188. Monson KL, Goldsmith W, Barbaro NM, Manley G. Significance of source and size in the mechanical response of human cerebral blood vessels. J Biomech. 2005 Apr; 38(4):737-44. PMID: 15713294.
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    189. Meeker M, Du R, Bacchetti P, Privitera CM, Larson MD, Holland MC, Manley G. Pupil examination: validity and clinical utility of an automated pupillometer. J Neurosci Nurs. 2005 Feb; 37(1):34-40. PMID: 15794443.
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    190. Oshio K, Binder DK, Liang Y, Bollen A, Feuerstein B, Berger MS, Manley G. Expression of the aquaporin-1 water channel in human glial tumors. Neurosurgery. 2005 Feb; 56(2):375-81; discussion 375-81. PMID: 15670385.
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    191. Hemphill JC, Morabito D, Farrant M, Manley G. Brain tissue oxygen monitoring in intracerebral hemorrhage. Neurocrit Care. 2005; 3(3):260-70. PMID: 16377842.
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    192. Barton CW, Hemphill JC, Morabito D, Manley G. A novel method of evaluating the impact of secondary brain insults on functional outcomes in traumatic brain-injured patients. Acad Emerg Med. 2005 Jan; 12(1):1-6. PMID: 15635130.
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    193. Le TH, Mukherjee P, Henry RG, Berman JI, Ware M, Manley G. Diffusion tensor imaging with three-dimensional fiber tractography of traumatic axonal shearing injury: an imaging correlate for the posterior callosal "disconnection" syndrome: case report. Neurosurgery. 2005; 56(1):189. PMID: 15617604.
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    194. Le TH, Mukherjee P, Henry RG, Berman JI, Ware M, Manley G. Diffusion Tensor Imaging with Three-dimensional Fiber Tractography of Traumatic Axonal Shearing Injury: An Imaging Correlate for the Posterior Callosal "Disconnection" Syndrome: Case Report. Neurosurgery. 2005 Jan 01; 56(1):E195-E201. PMID: 28184703.
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    195. Oshio K, Watanabe H, Song Y, Verkman AS, Manley G. Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1. FASEB J. 2005 Jan; 19(1):76-8. PMID: 15533949.
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    196. Papadopoulos MC, Manley G, Krishna S, Verkman AS. Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J. 2004 Aug; 18(11):1291-3. PMID: 15208268.
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    197. Govindaraju V, Gauger GE, Manley G, Ebel A, Meeker M, Maudsley AA. Volumetric proton spectroscopic imaging of mild traumatic brain injury. AJNR Am J Neuroradiol. 2004 May; 25(5):730-7. PMID: 15140711.
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    198. Mosenthal AC, Livingston DH, Lavery RF, Knudson MM, Lee S, Morabito D, Manley G, Nathens A, Jurkovich G, Hoyt DB, Coimbra R. The effect of age on functional outcome in mild traumatic brain injury: 6-month report of a prospective multicenter trial. J Trauma. 2004 May; 56(5):1042-8. PMID: 15179244.
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    199. Binder DK, Lyon R, Manley G. Transcranial motor evoked potential recording in a case of Kernohan's notch syndrome: case report. Neurosurgery. 2004 Apr; 54(4):999-1002; discussion 1002-3. PMID: 15046669.
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    200. Binder DK, Oshio K, Ma T, Verkman AS, Manley G. Increased seizure threshold in mice lacking aquaporin-4 water channels. Neuroreport. 2004 Feb 09; 15(2):259-62. PMID: 15076748.
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    201. Quiñones-Hinojosa A, Binder DK, Hemphill JC, Manley G. Diagnosis of posttraumatic transverse sinus thrombosis with magnetic resonance imaging/magnetic resonance venography: report of two cases. J Trauma. 2004 Jan; 56(1):201-4. PMID: 14749592.
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    202. Solenov E, Watanabe H, Manley G, Verkman AS. Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method. Am J Physiol Cell Physiol. 2004 Feb; 286(2):C426-32. PMID: 14576087.
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    203. Monson KL, Goldsmith W, Barbaro NM, Manley G. Axial mechanical properties of fresh human cerebral blood vessels. J Biomech Eng. 2003 Apr; 125(2):288-94. PMID: 12751292.
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    204. Knudson MM, Lee S, Erickson V, Morabito D, Derugin N, Manley G. Tissue oxygen monitoring during hemorrhagic shock and resuscitation: a comparison of lactated Ringer's solution, hypertonic saline dextran, and HBOC-201. J Trauma. 2003 Feb; 54(2):242-52. PMID: 12579047.
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    205. Manley G, Hemphill JC, Morabito D, Erickson V, Holcroft JJ, Derugin N, Knudson MM. Small-volume resuscitation with the hemoglobin substitute HBOC-201: effect on brain tissue oxygenation. Adv Exp Med Biol. 2003; 530:311-7. PMID: 14562727.
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    206. Zhang L, Bae J, Hardy WN, Monson KL, Manley G, Goldsmith W, Yang KH, King AI. Computational study of the contribution of the vasculature on the dynamic response of the brain. Stapp Car Crash J. 2002 Nov; 46:145-64. PMID: 17096223.
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    207. Lee SK, Morabito D, Hemphill JC, Erickson V, Holcroft JJ, Derugin N, Knudson MM, Manley G. Small-volume resuscitation with HBOC-201: effects on cardiovascular parameters and brain tissue oxygen tension in an out-of-hospital model of hemorrhage in swine. Acad Emerg Med. 2002 Oct; 9(10):969-76. PMID: 12359531.
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    208. Manley G, Larson MD. Infrared pupillometry during uncal herniation. J Neurosurg Anesthesiol. 2002 Jul; 14(3):223-8. PMID: 12172296.
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    209. Solenov EI, Vetrivel L, Oshio K, Manley G, Verkman AS. Optical measurement of swelling and water transport in spinal cord slices from aquaporin null mice. J Neurosci Methods. 2002 Jan 15; 113(1):85-90. PMID: 11741725.
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    210. Manley G, Knudson MM, Morabito D, Damron S, Erickson V, Pitts L. Hypotension, hypoxia, and head injury: frequency, duration, and consequences. Arch Surg. 2001 Oct; 136(10):1118-23. PMID: 11585502.
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    211. Yang B, Verbavatz JM, Song Y, Vetrivel L, Manley G, Kao WM, Ma T, Verkman AS. Skeletal muscle function and water permeability in aquaporin-4 deficient mice. Am J Physiol Cell Physiol. 2000 Jun; 278(6):C1108-15. PMID: 10837338.
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    212. George TI, Manley G, Koehler JE, Hung VS, McDermott M, Bollen A. Detection of Bartonella henselae by polymerase chain reaction in brain tissue of an immunocompromised patient with multiple enhancing lesions. Case report and review of the literature. J Neurosurg. 1998 Oct; 89(4):640-4. PMID: 9761060.
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