Loading...

George Carlson, PhD

Title(s)Professor, Institute for Neurodegenerative Diseases
SchoolSchool of Medicine
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone415-353-3161
vCardDownload vCard
    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Research 
    Collapse Research Activities and Funding
    Tauopathy in AD and FTD - Molecular Determinants of Phenotypic Diversity
    NIH/NIA RF1AG056151Sep 30, 2017 - Jun 30, 2022
    Role: Co-Principal Investigator
    CNS Stem Cells for neurodegenerative disease research
    NIH/NIA R21AG044720Aug 15, 2014 - May 31, 2016
    Role: Principal Investigator
    CNS Stem Cells for Alzheimer's Disease Therapy
    NIH/NIA R41AG022736Sep 30, 2004 - Mar 31, 2006
    Role: Principal Investigator
    24-Capillary Reveal Mutation Discovery System
    NIH/NCRR S10RR017764May 1, 2003 - Apr 30, 2004
    Role: Principal Investigator
    Genetics of Prion Susceptibility in vitro
    NIH/NINDS P01NS041997Sep 30, 2001 - Sep 14, 2011
    Role: Principal Investigator
    TRANSMISSIBLE AND GENETIC NEURODENGENERATIVE DISEASES
    NIH/NINDS P01NS022786Jul 1, 1997 - Jun 30, 2000
    Role: Co-Principal Investigator
    ANIMAL FACILITY IMPROVEMENT
    NIH/NCRR G20RR007976Sep 30, 1992 - Sep 29, 1993
    Role: Principal Investigator
    SMALL INSTRUMENTATION GRANT
    NIH/NIA S15AG011109Sep 1, 1992 - Aug 31, 1993
    Role: Principal Investigator
    TRANSGENIC MODELS FOR ALZHEIMERS DISEASE
    NIH/NIA R01AG010681Sep 29, 1991 - Jun 30, 1998
    Role: Principal Investigator
    SMALL INSTRUMENTATION GRANT
    NIH/NCI S15CA056002Sep 1, 1991 - Aug 31, 1992
    Role: Principal Investigator
    SMALL INSTRUMENTATION GRANT
    NIH/NIGMS S15GM045468Jun 1, 1990 - May 31, 1991
    Role: Principal Investigator
    H-2 ASSOCIATED NATURAL RESISTANCE
    NIH/NCI R01CA028231Apr 24, 1990 - Jun 30, 1988
    Role: Principal Investigator
    MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM
    NIH/NCRR S03RR003526Mar 1, 1990 - Feb 29, 1992
    Role: Principal Investigator
    BIOMEDICAL RESEARCH SUPPORT GRANT
    NIH/NCRR S07RR006017Apr 1, 1989 - Sep 29, 1992
    Role: Principal Investigator
    MITOTIC RECOMBINATION IN MAMMALIAN CELLS
    NIH/NIGMS R01GM037821Jul 1, 1987 - Nov 30, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Core transcriptional regulatory circuits in prion diseases. Mol Brain. 2020 01 20; 13(1):10. Kim TK, Lee I, Cho JH, Canine B, Keller A, Price ND, Hwang D, Carlson G, Hood L. PMID: 31959236.
      View in: PubMed   Mentions: 1     Fields:    
    2. Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human a-synuclein. Acta Neuropathol Commun. 2019 05 20; 7(1):81. Krejciova Z, Carlson GA, Giles K, Prusiner SB. PMID: 31109379.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Tau impairs neural circuits, dominating amyloid-ß effects, in Alzheimer models in vivo. Nat Neurosci. 2019 01; 22(1):57-64. Busche MA, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, Kamath TV, Carlson GA, Nelken I, Hyman BT. PMID: 30559471.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    4. Tau reduction in the presence of amyloid-ß prevents tau pathology and neuronal death in vivo. Brain. 2018 07 01; 141(7):2194-2212. DeVos SL, Corjuc BT, Commins C, Dujardin S, Bannon RN, Corjuc D, Moore BD, Bennett RE, Jorfi M, Gonzales JA, Dooley PM, Roe AD, Pitstick R, Irimia D, Frosch MP, Carlson GA, Hyman BT. PMID: 29733334.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    5. Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice. Proc Natl Acad Sci U S A. 2017 12 19; 114(51):E11029-E11036. Johnson NR, Condello C, Guan S, Oehler A, Becker J, Gavidia M, Carlson GA, Giles K, Prusiner SB. PMID: 29203673.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. A novel vector for transgenesis in the rat CNS. Acta Neuropathol Commun. 2017 Nov 21; 5(1):84. Lopez TP, Giles K, Dugger BN, Oehler A, Condello C, Krejciova Z, Castaneda JA, Carlson GA, Prusiner SB. PMID: 29157304.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    7. Neurodegenerative Disease Transmission and Transgenesis in Mice. Cold Spring Harb Perspect Biol. 2017 Nov 01; 9(11). Dugger BN, Perl DP, Carlson GA. PMID: 28193724.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    8. Prion Protein and Genetic Susceptibility to Diseases Caused by Its Misfolding. Prog Mol Biol Transl Sci. 2017; 150:123-145. Carlson GA. PMID: 28838658.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aß Peptides. Circ Res. 2017 Jul 21; 121(3):258-269. Park L, Uekawa K, Garcia-Bonilla L, Koizumi K, Murphy M, Pistik R, Younkin L, Younkin S, Zhou P, Carlson G, Anrather J, Iadecola C. PMID: 28515043.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    10. Enhanced Tau Aggregation in the Presence of Amyloid ß. Am J Pathol. 2017 Jul; 187(7):1601-1612. Bennett RE, DeVos SL, Dujardin S, Corjuc B, Gor R, Gonzalez J, Roe AD, Frosch MP, Pitstick R, Carlson GA, Hyman BT. PMID: 28500862.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    11. Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro. Am J Pathol. 2017 Jun; 187(6):1399-1412. Nobuhara CK, DeVos SL, Commins C, Wegmann S, Moore BD, Roe AD, Costantino I, Frosch MP, Pitstick R, Carlson GA, Hock C, Nitsch RM, Montrasio F, Grimm J, Cheung AE, Dunah AW, Wittmann M, Bussiere T, Weinreb PH, Hyman BT, Takeda S. PMID: 28408124.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    12. Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease. Synapse. 2017 06; 71(6). Pickett EK, Henstridge CM, Allison E, Pitstick R, Pooler A, Wegmann S, Carlson G, Hyman BT, Spires-Jones TL. PMID: 28196395.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    13. High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds. Hum Mol Genet. 2017 03 01; 26(5):913-922. Ament SA, Pearl JR, Grindeland A, St Claire J, Earls JC, Kovalenko M, Gillis T, Mysore J, Gusella JF, Lee JM, Kwak S, Howland D, Lee MY, Baxter D, Scherler K, Wang K, Geman D, Carroll JB, MacDonald ME, Carlson G, Wheeler VC, Price ND, Hood LE. PMID: 28334820.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    14. The familial dysautonomia disease gene IKBKAP is required in the developing and adult mouse central nervous system. Dis Model Mech. 2017 05 01; 10(5):605-618. Chaverra M, George L, Mergy M, Waller H, Kujawa K, Murnion C, Sharples E, Thorne J, Podgajny N, Grindeland A, Ueki Y, Eiger S, Cusick C, Babcock AM, Carlson GA, Lefcort F. PMID: 28167615.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    15. Human tau increases amyloid ß plaque size but not amyloid ß-mediated synapse loss in a novel mouse model of Alzheimer's disease. Eur J Neurosci. 2016 12; 44(12):3056-3066. Jackson RJ, Rudinskiy N, Herrmann AG, Croft S, Kim JM, Petrova V, Ramos-Rodriguez JJ, Pitstick R, Wegmann S, Garcia-Alloza M, Carlson GA, Hyman BT, Spires-Jones TL. PMID: 27748574.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    16. Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy. Cell Chem Biol. 2016 08 18; 23(8):992-1001. Young ZT, Rauch JN, Assimon VA, Jinwal UK, Ahn M, Li X, Dunyak BM, Ahmad A, Carlson GA, Srinivasan SR, Zuiderweg ER, Dickey CA, Gestwicki JE. PMID: 27499529.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    17. Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients. Ann Neurol. 2016 09; 80(3):355-67. Takeda S, Commins C, DeVos SL, Nobuhara CK, Wegmann S, Roe AD, Costantino I, Fan Z, Nicholls SB, Sherman AE, Trisini Lipsanopoulos AT, Scherzer CR, Carlson GA, Pitstick R, Peskind ER, Raskind MA, Li G, Montine TJ, Frosch MP, Hyman BT. PMID: 27351289.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    18. Improvement of ENU Mutagenesis Efficiency Using Serial Injection and Mismatch Repair Deficiency Mice. PLoS One. 2016; 11(7):e0159377. Gallego-Llamas J, Timms AE, Pitstick R, Peters J, Carlson GA, Beier DR. PMID: 27441645.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    19. Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis. Hum Mol Genet. 2016 06 01; 25(11):2245-2255. Husson H, Moreno S, Smith LA, Smith MM, Russo RJ, Pitstick R, Sergeev M, Ledbetter SR, Bukanov NO, Lane M, Zhang K, Billot K, Carlson G, Shah J, Meijer L, Beier DR, Ibraghimov-Beskrovnaya O. PMID: 27053712.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    20. A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone. PLoS One. 2016; 11(2):e0149410. Daude N, Lee I, Kim TK, Janus C, Glaves JP, Gapeshina H, Yang J, Sykes BD, Carlson GA, Hood LE, Westaway D. PMID: 26894278.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    21. Brain Aggregates: An Effective In Vitro Cell Culture System Modeling Neurodegenerative Diseases. J Neuropathol Exp Neurol. 2016 Mar; 75(3):256-62. Ahn M, Kalume F, Pitstick R, Oehler A, Carlson G, DeArmond SJ. PMID: 26851378.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    22. Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity. EMBO J. 2015 Dec 14; 34(24):3028-41. Wegmann S, Maury EA, Kirk MJ, Saqran L, Roe A, DeVos SL, Nicholls S, Fan Z, Takeda S, Cagsal-Getkin O, William CM, Spires-Jones TL, Pitstick R, Carlson GA, Pooler AM, Hyman BT. PMID: 26538322.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    23. Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain. Nat Commun. 2015 Oct 13; 6:8490. Takeda S, Wegmann S, Cho H, DeVos SL, Commins C, Roe AD, Nicholls SB, Carlson GA, Pitstick R, Nobuhara CK, Costantino I, Frosch MP, Müller DJ, Irimia D, Hyman BT. PMID: 26458742.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    24. Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease. Acta Neuropathol Commun. 2015 Mar 24; 3:14. Pooler AM, Polydoro M, Maury EA, Nicholls SB, Reddy SM, Wegmann S, William C, Saqran L, Cagsal-Getkin O, Pitstick R, Beier DR, Carlson GA, Spires-Jones TL, Hyman BT. PMID: 25853174.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    25. Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice. Mamm Genome. 2015 Feb; 26(1-2):80-93. Anderson SR, Lee I, Ebeling C, Stephenson DA, Schweitzer KM, Baxter D, Moon TM, LaPierre S, Jaques B, Silvius D, Wegner M, Hood LE, Carlson G, Gunn TM. PMID: 25399070.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    26. A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice. Lipids Health Dis. 2014 Oct 31; 13:167. Helmering J, Juan T, Li CM, Chhoa M, Baron W, Gyuris T, Richards WG, Turk JR, Lawrence J, Cosgrove PA, Busby J, Kim KW, Kaufman SA, Cummings C, Carlson G, Véniant MM, Lloyd DJ. PMID: 25361754.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    27. Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy. Stroke. 2014 Jun; 45(6):1815-21. Park L, Koizumi K, El Jamal S, Zhou P, Previti ML, Van Nostrand WE, Carlson G, Iadecola C. PMID: 24781082.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    28. Development of a novel cellular model of Alzheimer's disease utilizing neurosphere cultures derived from B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J embryonic mouse brain. Springerplus. 2014; 3:161. Ghate PS, Sidhar H, Carlson GA, Giri RK. PMID: 25140287.
      View in: PubMed   Mentions:
    29. Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs. J Cell Biol. 2014 Feb 03; 204(3):423-41. Rouvinski A, Karniely S, Kounin M, Moussa S, Goldberg MD, Warburg G, Lyakhovetsky R, Papy-Garcia D, Kutzsche J, Korth C, Carlson GA, Godsave SF, Peters PJ, Luhr K, Kristensson K, Taraboulos A. PMID: 24493590.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    30. Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy. Neurosci Lett. 2014 Mar 06; 562:63-8. Spires-Jones TL, Friedman T, Pitstick R, Polydoro M, Roe A, Carlson GA, Hyman BT. PMID: 24462887.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    31. Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology. J Comp Neurol. 2013 Dec 15; 521(18):4236-48. Pooler AM, Polydoro M, Wegmann SK, Pitstick R, Kay KR, Sanchez L, Carlson GA, Gomez-Isla T, Albers MW, Spires-Jones TL, Hyman BT. PMID: 23839581.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    32. Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy. Neuropharmacology. 2014 Apr; 79:307-13. Graham DL, Gray AJ, Joyce JA, Yu D, O'Moore J, Carlson GA, Shearman MS, Dellovade TL, Hering H. PMID: 24326295.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    33. Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model. Acta Neuropathol. 2014 Feb; 127(2):257-70. Polydoro M, Dzhala VI, Pooler AM, Nicholls SB, McKinney AP, Sanchez L, Pitstick R, Carlson GA, Staley KJ, Spires-Jones TL, Hyman BT. PMID: 24271788.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    34. Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. PLoS One. 2013; 8(11):e80834. Kopeikina KJ, Wegmann S, Pitstick R, Carlson GA, Bacskai BJ, Betensky RA, Hyman BT, Spires-Jones TL. PMID: 24278327.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    35. Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):18698-703. George L, Chaverra M, Wolfe L, Thorne J, Close-Davis M, Eibs A, Riojas V, Grindeland A, Orr M, Carlson GA, Lefcort F. PMID: 24173031.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    36. Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400. FEBS Lett. 2013 Nov 15; 587(22):3722-8. Cameron A, Giacomozzi B, Joyce J, Gray A, Graham D, Ousson S, Neny M, Beher D, Carlson G, O'Moore J, Shearman M, Hering H. PMID: 24113653.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    37. Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease. J Neurosci. 2013 Aug 14; 33(33):13300-11. Polydoro M, de Calignon A, Suárez-Calvet M, Sanchez L, Kay KR, Nicholls SB, Roe AD, Pitstick R, Carlson GA, Gómez-Isla T, Spires-Jones TL, Hyman BT. PMID: 23946388.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    38. RML prions act through Mahogunin and Attractin-independent pathways. Prion. 2013 Jul-Aug; 7(4):267-71. Gunn TM, Carlson GA. PMID: 23787699.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    39. Synaptic alterations in the rTg4510 mouse model of tauopathy. J Comp Neurol. 2013 Apr 15; 521(6):1334-53. Kopeikina KJ, Polydoro M, Tai HC, Yaeger E, Carlson GA, Pitstick R, Hyman BT, Spires-Jones TL. PMID: 23047530.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    40. Innate immunity receptor CD36 promotes cerebral amyloid angiopathy. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):3089-94. Park L, Zhou J, Zhou P, Pistick R, El Jamal S, Younkin L, Pierce J, Arreguin A, Anrather J, Younkin SG, Carlson GA, McEwen BS, Iadecola C. PMID: 23382216.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    41. Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion disease. PLoS One. 2013; 8(1):e55575. Silvius D, Pitstick R, Ahn M, Meishery D, Oehler A, Barsh GS, DeArmond SJ, Carlson GA, Gunn TM. PMID: 23383230.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    42. Brain and circulating levels of Aß1-40 differentially contribute to vasomotor dysfunction in the mouse brain. Stroke. 2013 Jan; 44(1):198-204. Park L, Zhou P, Koizumi K, El Jamal S, Previti ML, Van Nostrand WE, Carlson G, Iadecola C. PMID: 23204056.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    43. Genotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tau. PLoS One. 2012; 7(6):e39328. Orr ME, Pitstick R, Canine B, Ashe KH, Carlson GA. PMID: 22723997.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    44. LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation. J Mol Biol. 2012 Sep 28; 422(4):556-574. Ehsani S, Salehzadeh A, Huo H, Reginold W, Pocanschi CL, Ren H, Wang H, So K, Sato C, Mehrabian M, Strome R, Trimble WS, Hazrati LN, Rogaeva E, Westaway D, Carlson GA, Schmitt-Ulms G. PMID: 22687393.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    45. Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrP(C)-deficiency. Proc Natl Acad Sci U S A. 2012 Jun 05; 109(23):9035-40. Daude N, Wohlgemuth S, Brown R, Pitstick R, Gapeshina H, Yang J, Carlson GA, Westaway D. PMID: 22619325.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    46. A brain aggregate model gives new insights into the pathobiology and treatment of prion diseases. J Neuropathol Exp Neurol. 2012 May; 71(5):449-66. Bajsarowicz K, Ahn M, Ackerman L, Dearmond BN, Carlson G, DeArmond SJ. PMID: 22507918.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    47. Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia. Front Pharmacol. 2012; 3:42. Spires-Jones TL, Fox LM, Rozkalne A, Pitstick R, Carlson GA, Kazantsev AG. PMID: 22416232.
      View in: PubMed   Mentions:
    48. Propagation of tau pathology in a model of early Alzheimer's disease. Neuron. 2012 Feb 23; 73(4):685-97. de Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT. PMID: 22365544.
      View in: PubMed   Mentions: 386     Fields:    Translation:HumansAnimalsCells
    49. Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation. PLoS Pathog. 2011 Nov; 7(11):e1002391. Westaway D, Genovesi S, Daude N, Brown R, Lau A, Lee I, Mays CE, Coomaraswamy J, Canine B, Pitstick R, Herbst A, Yang J, Ko KW, Schmitt-Ulms G, Dearmond SJ, McKenzie D, Hood L, Carlson GA. PMID: 22114562.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    50. Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. Am J Pathol. 2011 Oct; 179(4):2071-82. Kopeikina KJ, Carlson GA, Pitstick R, Ludvigson AE, Peters A, Luebke JI, Koffie RM, Frosch MP, Hyman BT, Spires-Jones TL. PMID: 21854751.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    51. The effect of HIV protease inhibitors on amyloid-ß peptide degradation and synthesis in human cells and Alzheimer's disease animal model. J Neuroimmune Pharmacol. 2012 Jun; 7(2):412-23. Lan X, Kiyota T, Hanamsagar R, Huang Y, Andrews S, Peng H, Zheng JC, Swindells S, Carlson GA, Ikezu T. PMID: 21826404.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    52. Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model. J Neuropathol Exp Neurol. 2011 Jul; 70(7):588-95. Fox LM, William CM, Adamowicz DH, Pitstick R, Carlson GA, Spires-Jones TL, Hyman BT. PMID: 21666499.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    53. Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):5063-8. Park L, Wang G, Zhou P, Zhou J, Pitstick R, Previti ML, Younkin L, Younkin SG, Van Nostrand WE, Cho S, Anrather J, Carlson GA, Iadecola C. PMID: 21383152.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    54. Principal network analysis: identification of subnetworks representing major dynamics using gene expression data. Bioinformatics. 2011 Feb 01; 27(3):391-8. Kim Y, Kim TK, Kim Y, Yoo J, You S, Lee I, Carlson G, Hood L, Choi S, Hwang D. PMID: 21193522.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    55. Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron. 2010 Dec 22; 68(6):1067-81. Hoover BR, Reed MN, Su J, Penrod RD, Kotilinek LA, Grant MK, Pitstick R, Carlson GA, Lanier LM, Yuan LL, Ashe KH, Liao D. PMID: 21172610.
      View in: PubMed   Mentions: 246     Fields:    Translation:AnimalsCells
    56. Generation of antisera to purified prions in lipid rafts. Prion. 2010 Apr-Jun; 4(2):94-104. Hnasko R, Serban AV, Carlson G, Prusiner SB, Stanker LH. PMID: 20647769.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    57. Caspase activation precedes and leads to tangles. Nature. 2010 Apr 22; 464(7292):1201-4. de Calignon A, Fox LM, Pitstick R, Carlson GA, Bacskai BJ, Spires-Jones TL, Hyman BT. PMID: 20357768.
      View in: PubMed   Mentions: 186     Fields:    Translation:HumansAnimalsCells
    58. Systems biology and the discovery of diagnostic biomarkers. Dis Markers. 2010; 28(4):199-207. Wang K, Lee I, Carlson G, Hood L, Galas D. PMID: 20534905.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    59. Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones. PLoS Pathog. 2009 Oct; 5(10):e1000608. Watts JC, Huo H, Bai Y, Ehsani S, Jeon AH, Won AH, Shi T, Daude N, Lau A, Young R, Xu L, Carlson GA, Williams D, Westaway D, Schmitt-Ulms G. PMID: 19798432.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    60. The Prion Disease Database: a comprehensive transcriptome resource for systems biology research in prion diseases. Database (Oxford). 2009; 2009:bap011. Gehlenborg N, Hwang D, Lee IY, Yoo H, Baxter D, Petritis B, Pitstick R, Marzolf B, Dearmond SJ, Carlson GA, Hood L. PMID: 20157484.
      View in: PubMed   Mentions: 14     Fields:    
    61. New variants in the Enpp1 and Ptpn6 genes cause low BMD, crystal-related arthropathy, and vascular calcification. J Bone Miner Res. 2009 Sep; 24(9):1552-64. Babij P, Roudier M, Graves T, Han CY, Chhoa M, Li CM, Juan T, Morony S, Grisanti M, Li X, Yu L, Dwyer D, Lloyd DJ, Bass MB, Richards WG, Ebeling C, Amato J, Carlson G. PMID: 19419305.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    62. Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy. J Neuropathol Exp Neurol. 2009 Jul; 68(7):757-61. de Calignon A, Spires-Jones TL, Pitstick R, Carlson GA, Hyman BT. PMID: 19535996.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    63. A systems approach to prion disease. Mol Syst Biol. 2009; 5:252. Hwang D, Lee IY, Yoo H, Gehlenborg N, Cho JH, Petritis B, Baxter D, Pitstick R, Young R, Spicer D, Price ND, Hohmann JG, Dearmond SJ, Carlson GA, Hood LE. PMID: 19308092.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    64. Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice. J Lipid Res. 2009 Mar; 50(3):534-45. Juan T, Véniant MM, Helmering J, Babij P, Baker DM, Damore MA, Bass MB, Gyuris T, Chhoa M, Li CM, Ebeling C, Amato J, Carlson GA, Lloyd DJ. PMID: 18974039.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    65. Genes contributing to prion pathogenesis. J Gen Virol. 2008 Jul; 89(Pt 7):1777-1788. Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz J, Epstein CJ, Cruz TD, Kuziel WA, Maeda N, Sap J, Ashe KH, Carlson GA, Tesseur I, Wyss-Coray T, Mucke L, Weisgraber KH, Mahley RW, Cohen FE, Prusiner SB. PMID: 18559949.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    66. Cholesterol transporter ATP-binding cassette A1 (ABCA1) is elevated in prion disease and affects PrPC and PrPSc concentrations in cultured cells. J Gen Virol. 2008 Jun; 89(Pt 6):1525-1532. Kumar R, McClain D, Young R, Carlson GA. PMID: 18474570.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    67. In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. J Neurosci. 2008 Jan 23; 28(4):862-7. Spires-Jones TL, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek JD, Jones PB, Bacskai BJ, Feany MB, Carlson GA, Ashe KH, Lewis J, Hyman BT. PMID: 18216194.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    68. Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein. Proc Natl Acad Sci U S A. 2008 Jan 29; 105(4):1347-52. Park L, Zhou P, Pitstick R, Capone C, Anrather J, Norris EH, Younkin L, Younkin S, Carlson G, McEwen BS, Iadecola C. PMID: 18202172.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    69. The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections. EMBO J. 2007 Sep 05; 26(17):4038-50. Watts JC, Drisaldi B, Ng V, Yang J, Strome B, Horne P, Sy MS, Yoong L, Young R, Mastrangelo P, Bergeron C, Fraser PE, Carlson GA, Mount HT, Schmitt-Ulms G, Westaway D. PMID: 17703189.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    70. Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation. Am J Pathol. 2006 Oct; 169(4):1365-75. Murakami T, Paitel E, Kawarabayashi T, Ikeda M, Chishti MA, Janus C, Matsubara E, Sasaki A, Kawarai T, Phinney AL, Harigaya Y, Horne P, Egashira N, Mishima K, Hanna A, Yang J, Iwasaki K, Takahashi M, Fujiwara M, Ishiguro K, Bergeron C, Carlson GA, Abe K, Westaway D, St George-Hyslop P, Shoji M. PMID: 17003492.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    71. Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy. Am J Pathol. 2006 May; 168(5):1598-607. Spires TL, Orne JD, SantaCruz K, Pitstick R, Carlson GA, Ashe KH, Hyman BT. PMID: 16651626.
      View in: PubMed   Mentions: 130     Fields:    Translation:AnimalsCells
    72. Prion infection of mouse neurospheres. Proc Natl Acad Sci U S A. 2006 Mar 07; 103(10):3875-80. Giri RK, Young R, Pitstick R, DeArmond SJ, Prusiner SB, Carlson GA. PMID: 16495413.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    73. Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). J Neurosci. 2005 Nov 16; 25(46):10637-47. Ramsden M, Kotilinek L, Forster C, Paulson J, McGowan E, SantaCruz K, Guimaraes A, Yue M, Lewis J, Carlson G, Hutton M, Ashe KH. PMID: 16291936.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimalsCells
    74. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Proc Natl Acad Sci U S A. 2005 Jun 21; 102(25):8972-7. Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St George-Hyslop P, Carlson GA, Westaway D. PMID: 15951428.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    75. NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. J Neurosci. 2005 Feb 16; 25(7):1769-77. Park L, Anrather J, Zhou P, Frys K, Pitstick R, Younkin S, Carlson GA, Iadecola C. PMID: 15716413.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    76. Implementing large-scale ENU mutagenesis screens in North America. Genetica. 2004 Sep; 122(1):51-64. Clark AT, Goldowitz D, Takahashi JS, Vitaterna MH, Siepka SM, Peters LL, Frankel WN, Carlson GA, Rossant J, Nadeau JH, Justice MJ. PMID: 15619961.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    77. Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression. Hum Mol Genet. 2004 Sep 15; 13(18):1989-97. Krezowski J, Knudson D, Ebeling C, Pitstick R, Giri RK, Schenk D, Westaway D, Younkin L, Younkin SG, Ashe KH, Carlson GA. PMID: 15254013.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    78. Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice. J Neurochem. 2004 Jun; 89(5):1308-12. Li F, Calingasan NY, Yu F, Mauck WM, Toidze M, Almeida CG, Takahashi RH, Carlson GA, Flint Beal M, Lin MT, Gouras GK. PMID: 15147524.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimals
    79. Abeta-induced vascular oxidative stress and attenuation of functional hyperemia in mouse somatosensory cortex. J Cereb Blood Flow Metab. 2004 Mar; 24(3):334-42. Park L, Anrather J, Forster C, Kazama K, Carlson GA, Iadecola C. PMID: 15091114.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    80. In vivo reduction of amyloid-beta by a mutant copper transporter. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14193-8. Phinney AL, Drisaldi B, Schmidt SD, Lugowski S, Coronado V, Liang Y, Horne P, Yang J, Sekoulidis J, Coomaraswamy J, Chishti MA, Cox DW, Mathews PM, Nixon RA, Carlson GA, St George-Hyslop P, Westaway D. PMID: 14617772.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    81. A welcoming environment for amyloid plaques. Nat Neurosci. 2003 Apr; 6(4):328-30. Carlson GA. PMID: 12658277.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    82. Postexposure prophylaxis against transmissible spongiform encephalopathies: CpG oligodeoxynucleotides in mice. Lancet. 2002 Jul 20; 360(9328):184. Carlson GA. PMID: 12133649.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    83. Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein. Am J Physiol Heart Circ Physiol. 2002 Jul; 283(1):H315-23. Niwa K, Kazama K, Younkin L, Younkin SG, Carlson GA, Iadecola C. PMID: 12063304.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimals
    84. Mammalian prion proteins: enigma, variation and vaccination. Trends Biochem Sci. 2002 Jun; 27(6):301-7. Westaway D, Carlson GA. PMID: 12069790.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsPHPublic Health
    85. The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J Neurosci. 2002 Mar 01; 22(5):1858-67. Westerman MA, Cooper-Blacketer D, Mariash A, Kotilinek L, Kawarabayashi T, Younkin LH, Carlson GA, Younkin SG, Ashe KH. PMID: 11880515.
      View in: PubMed   Mentions: 209     Fields:    Translation:HumansAnimals
    86. Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein. Neurobiol Dis. 2002 Feb; 9(1):61-8. Niwa K, Kazama K, Younkin SG, Carlson GA, Iadecola C. PMID: 11848685.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimals
    George's Networks
    Concepts (406)
    Derived automatically from this person's publications.
    _
    Co-Authors (15)
    People in Profiles who have published with this person.
    _
    Similar People (55)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _