George Carlson, PhD

TitleAdj Instr-HCOMP
SchoolUCSF School of Medicine
DepartmentInstitute for Neurodegenerative Diseases
Address675 Nelson Rising Lane
San Francisco CA 94158
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Tauopathy in AD and FTD - Molecular Determinants of Phenotypic Diversity
    NIH/NIA RF1AG056151Sep 30, 2017 - Jun 30, 2022
    Role: Co-Principal Investigator
    CNS Stem Cells for neurodegenerative disease research
    NIH/NIA R21AG044720Aug 15, 2014 - May 31, 2016
    Role: Principal Investigator
    CNS Stem Cells for Alzheimer's Disease Therapy
    NIH/NIA R41AG022736Sep 30, 2004 - Mar 31, 2006
    Role: Principal Investigator
    24-Capillary Reveal Mutation Discovery System
    NIH/NCRR S10RR017764May 1, 2003 - Apr 30, 2004
    Role: Principal Investigator
    Genetics of Prion Susceptibility in vitro
    NIH/NINDS P01NS041997Sep 30, 2001 - Jun 30, 2013
    Role: Principal Investigator
    NIH/NCRR G20RR007976Sep 30, 1992 - Sep 29, 1993
    Role: Principal Investigator
    NIH/NIA S15AG011109Sep 1, 1992 - Aug 31, 1993
    Role: Principal Investigator
    NIH/NIA R01AG010681Sep 29, 1991 - Jun 30, 1998
    Role: Principal Investigator
    NIH/NCI S15CA056002Sep 1, 1991 - Aug 31, 1992
    Role: Principal Investigator
    NIH/NIGMS S15GM045468Jun 1, 1990 - May 31, 1991
    Role: Principal Investigator
    NIH/NCRR S03RR003526Mar 1, 1990 - Aug 31, 1994
    Role: Principal Investigator
    NIH/NCRR S07RR006017Apr 1, 1989 - Sep 29, 1992
    Role: Principal Investigator
    NIH/NIGMS R01GM037821Jul 1, 1987 - Jun 30, 1991
    Role: Principal Investigator
    NIH/NINDS P01NS022786Sep 1, 1985 - Jun 30, 2000
    Role: Co-Principal Investigator
    NIH/NCI R01CA028231Jul 1, 1980 - Dec 31, 1991
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Carlson G. Prion Protein and Genetic Susceptibility to Diseases Caused by Its Misfolding. Prog Mol Biol Transl Sci. 2017; 150:123-145. PMID: 28838658.
      View in: PubMed
    2. Park L, Uekawa K, Garcia-Bonilla L, Koizumi K, Murphy M, Pistik R, Younkin L, Younkin S, Zhou P, Carlson G, Anrather J, Iadecola C. Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aß Peptides. Circ Res. 2017 Jul 21; 121(3):258-269. PMID: 28515043.
      View in: PubMed
    3. Bennett RE, DeVos SL, Dujardin S, Corjuc B, Gor R, Gonzalez J, Roe AD, Frosch MP, Pitstick R, Carlson G, Hyman BT. Enhanced Tau Aggregation in the Presence of Amyloid ß. Am J Pathol. 2017 Jul; 187(7):1601-1612. PMID: 28500862.
      View in: PubMed
    4. Nobuhara CK, DeVos SL, Commins C, Wegmann S, Moore BD, Roe AD, Costantino I, Frosch MP, Pitstick R, Carlson G, Hock C, Nitsch RM, Montrasio F, Grimm J, Cheung AE, Dunah AW, Wittmann M, Bussiere T, Weinreb PH, Hyman BT, Takeda S. Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro. Am J Pathol. 2017 Jun; 187(6):1399-1412. PMID: 28408124.
      View in: PubMed
    5. Ament SA, Pearl JR, Grindeland A, St Claire J, Earls JC, Kovalenko M, Gillis T, Mysore J, Gusella JF, Lee JM, Kwak S, Howland D, Lee MY, Baxter D, Scherler K, Wang K, Geman D, Carroll JB, MacDonald ME, Carlson G, Wheeler VC, Price ND, Hood LE. High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds. Hum Mol Genet. 2017 Mar 01; 26(5):913-922. PMID: 28334820.
      View in: PubMed
    6. Dugger BN, Perl DP, Carlson G. Neurodegenerative Disease Transmission and Transgenesis in Mice. Cold Spring Harb Perspect Biol. 2017 Feb 13. PMID: 28193724.
      View in: PubMed
    7. Chaverra M, George L, Mergy M, Waller H, Kujawa K, Murnion C, Sharples E, Thorne J, Podgajny N, Grindeland A, Ueki Y, Eiger S, Cusick C, Babcock AM, Carlson G, Lefcort F. The familial dysautonomia disease gene IKBKAP is required in the developing and adult mouse central nervous system. Dis Model Mech. 2017 May 01; 10(5):605-618. PMID: 28167615.
      View in: PubMed
    8. Jackson RJ, Rudinskiy N, Herrmann AG, Croft S, Kim JM, Petrova V, Ramos-Rodriguez JJ, Pitstick R, Wegmann S, Garcia-Alloza M, Carlson G, Hyman BT, Spires-Jones TL. Human tau increases amyloid ß plaque size but not amyloid ß-mediated synapse loss in a novel mouse model of Alzheimer's disease. Eur J Neurosci. 2016 Dec; 44(12):3056-3066. PMID: 27748574.
      View in: PubMed
    9. Young ZT, Rauch JN, Assimon VA, Jinwal UK, Ahn M, Li X, Dunyak BM, Ahmad A, Carlson G, Srinivasan SR, Zuiderweg ER, Dickey CA, Gestwicki JE. Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy. Cell Chem Biol. 2016 Aug 18; 23(8):992-1001. PMID: 27499529; PMCID: PMC4992411 [Available on 08/18/17].
    10. Takeda S, Commins C, DeVos SL, Nobuhara CK, Wegmann S, Roe AD, Costantino I, Fan Z, Nicholls SB, Sherman AE, Trisini Lipsanopoulos AT, Scherzer CR, Carlson G, Pitstick R, Peskind ER, Raskind MA, Li G, Montine TJ, Frosch MP, Hyman BT. Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients. Ann Neurol. 2016 Sep; 80(3):355-67. PMID: 27351289; PMCID: PMC5016222 [Available on 09/01/17].
    11. Husson H, Moreno S, Smith LA, Smith MM, Russo RJ, Pitstick R, Sergeev M, Ledbetter SR, Bukanov NO, Lane M, Zhang K, Billot K, Carlson G, Shah J, Meijer L, Beier DR, Ibraghimov-Beskrovnaya O. Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis. Hum Mol Genet. 2016 Jun 01; 25(11):2245-2255. PMID: 27053712.
      View in: PubMed
    12. Daude N, Lee I, Kim TK, Janus C, Glaves JP, Gapeshina H, Yang J, Sykes BD, Carlson G, Hood LE, Westaway D. A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone. PLoS One. 2016; 11(2):e0149410. PMID: 26894278; PMCID: PMC4760942.
    13. Ahn M, Kalume F, Pitstick R, Oehler A, Carlson G, DeArmond SJ. Brain Aggregates: An Effective In Vitro Cell Culture System Modeling Neurodegenerative Diseases. J Neuropathol Exp Neurol. 2016 Mar; 75(3):256-62. PMID: 26851378; PMCID: PMC4902861 [Available on 03/01/17].
    14. Wegmann S, Maury EA, Kirk MJ, Saqran L, Roe A, DeVos SL, Nicholls S, Fan Z, Takeda S, Cagsal-Getkin O, William CM, Spires-Jones TL, Pitstick R, Carlson G, Pooler AM, Hyman BT. Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity. EMBO J. 2015 Dec 14; 34(24):3028-41. PMID: 26538322; PMCID: PMC4687785 [Available on 12/14/16].
    15. Takeda S, Wegmann S, Cho H, DeVos SL, Commins C, Roe AD, Nicholls SB, Carlson G, Pitstick R, Nobuhara CK, Costantino I, Frosch MP, Müller DJ, Irimia D, Hyman BT. Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain. Nat Commun. 2015 Oct 13; 6:8490. PMID: 26458742; PMCID: PMC4608380.
    16. Pooler AM, Polydoro M, Maury EA, Nicholls SB, Reddy SM, Wegmann S, William C, Saqran L, Cagsal-Getkin O, Pitstick R, Beier DR, Carlson G, Spires-Jones TL, Hyman BT. Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease. Acta Neuropathol Commun. 2015 Mar 24; 3:14. PMID: 25853174; PMCID: PMC4371800.
    17. Anderson SR, Lee I, Ebeling C, Stephenson DA, Schweitzer KM, Baxter D, Moon TM, LaPierre S, Jaques B, Silvius D, Wegner M, Hood LE, Carlson G, Gunn TM. Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice. Mamm Genome. 2015 Feb; 26(1-2):80-93. PMID: 25399070; PMCID: PMC4305468.
    18. Helmering J, Juan T, Li CM, Chhoa M, Baron W, Gyuris T, Richards WG, Turk JR, Lawrence J, Cosgrove PA, Busby J, Kim KW, Kaufman SA, Cummings C, Carlson G, Véniant MM, Lloyd DJ. A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice. Lipids Health Dis. 2014 Oct 31; 13:167. PMID: 25361754; PMCID: PMC4232700.
    19. Park L, Koizumi K, El Jamal S, Zhou P, Previti ML, Van Nostrand WE, Carlson G, Iadecola C. Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy. Stroke. 2014 Jun; 45(6):1815-21. PMID: 24781082; PMCID: PMC4284427.
    20. Ghate PS, Sidhar H, Carlson G, Giri RK. Development of a novel cellular model of Alzheimer's disease utilizing neurosphere cultures derived from B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J embryonic mouse brain. Springerplus. 2014; 3:161. PMID: 25140287; PMCID: PMC4137416.
    21. Rouvinski A, Karniely S, Kounin M, Moussa S, Goldberg MD, Warburg G, Lyakhovetsky R, Papy-Garcia D, Kutzsche J, Korth C, Carlson G, Godsave SF, Peters PJ, Luhr K, Kristensson K, Taraboulos A. Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs. J Cell Biol. 2014 Feb 03; 204(3):423-41. PMID: 24493590; PMCID: PMC3912534.
    22. Spires-Jones TL, Friedman T, Pitstick R, Polydoro M, Roe A, Carlson G, Hyman BT. Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy. Neurosci Lett. 2014 Mar 06; 562:63-8. PMID: 24462887; PMCID: PMC3992382.
    23. Pooler AM, Polydoro M, Wegmann SK, Pitstick R, Kay KR, Sanchez L, Carlson G, Gomez-Isla T, Albers MW, Spires-Jones TL, Hyman BT. Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology. J Comp Neurol. 2013 Dec 15; 521(18):4236-48. PMID: 23839581; PMCID: PMC3797265.
    24. Graham DL, Gray AJ, Joyce JA, Yu D, O'Moore J, Carlson G, Shearman MS, Dellovade TL, Hering H. Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy. Neuropharmacology. 2014 Apr; 79:307-13. PMID: 24326295.
      View in: PubMed
    25. Polydoro M, Dzhala VI, Pooler AM, Nicholls SB, McKinney AP, Sanchez L, Pitstick R, Carlson G, Staley KJ, Spires-Jones TL, Hyman BT. Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model. Acta Neuropathol. 2014 Feb; 127(2):257-70. PMID: 24271788; PMCID: PMC3946978.
    26. Kopeikina KJ, Wegmann S, Pitstick R, Carlson G, Bacskai BJ, Betensky RA, Hyman BT, Spires-Jones TL. Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. PLoS One. 2013; 8(11):e80834. PMID: 24278327; PMCID: PMC3835324.
    27. George L, Chaverra M, Wolfe L, Thorne J, Close-Davis M, Eibs A, Riojas V, Grindeland A, Orr M, Carlson G, Lefcort F. Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):18698-703. PMID: 24173031; PMCID: PMC3831979.
    28. Cameron A, Giacomozzi B, Joyce J, Gray A, Graham D, Ousson S, Neny M, Beher D, Carlson G, O'Moore J, Shearman M, Hering H. Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400. FEBS Lett. 2013 Nov 15; 587(22):3722-8. PMID: 24113653.
      View in: PubMed
    29. Polydoro M, de Calignon A, Suárez-Calvet M, Sanchez L, Kay KR, Nicholls SB, Roe AD, Pitstick R, Carlson G, Gómez-Isla T, Spires-Jones TL, Hyman BT. Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease. J Neurosci. 2013 Aug 14; 33(33):13300-11. PMID: 23946388; PMCID: PMC3742920.
    30. Gunn TM, Carlson G. RML prions act through Mahogunin and Attractin-independent pathways. Prion. 2013 Jul-Aug; 7(4):267-71. PMID: 23787699; PMCID: PMC3904309.
    31. Kopeikina KJ, Polydoro M, Tai HC, Yaeger E, Carlson G, Pitstick R, Hyman BT, Spires-Jones TL. Synaptic alterations in the rTg4510 mouse model of tauopathy. J Comp Neurol. 2013 Apr 15; 521(6):1334-53. PMID: 23047530; PMCID: PMC3725804.
    32. Park L, Zhou J, Zhou P, Pistick R, El Jamal S, Younkin L, Pierce J, Arreguin A, Anrather J, Younkin SG, Carlson G, McEwen BS, Iadecola C. Innate immunity receptor CD36 promotes cerebral amyloid angiopathy. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):3089-94. PMID: 23382216; PMCID: PMC3581946.
    33. Silvius D, Pitstick R, Ahn M, Meishery D, Oehler A, Barsh GS, DeArmond SJ, Carlson G, Gunn TM. Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion disease. PLoS One. 2013; 8(1):e55575. PMID: 23383230; PMCID: PMC3559536.
    34. Park L, Zhou P, Koizumi K, El Jamal S, Previti ML, Van Nostrand WE, Carlson G, Iadecola C. Brain and circulating levels of Aß1-40 differentially contribute to vasomotor dysfunction in the mouse brain. Stroke. 2013 Jan; 44(1):198-204. PMID: 23204056; PMCID: PMC3530010.
    35. Orr ME, Pitstick R, Canine B, Ashe KH, Carlson G. Genotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tau. PLoS One. 2012; 7(6):e39328. PMID: 22723997; PMCID: PMC3377636.
    36. Ehsani S, Salehzadeh A, Huo H, Reginold W, Pocanschi CL, Ren H, Wang H, So K, Sato C, Mehrabian M, Strome R, Trimble WS, Hazrati LN, Rogaeva E, Westaway D, Carlson G, Schmitt-Ulms G. LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation. J Mol Biol. 2012 Sep 28; 422(4):556-574. PMID: 22687393; PMCID: PMC5006934.
    37. Daude N, Wohlgemuth S, Brown R, Pitstick R, Gapeshina H, Yang J, Carlson G, Westaway D. Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrP(C)-deficiency. Proc Natl Acad Sci U S A. 2012 Jun 05; 109(23):9035-40. PMID: 22619325; PMCID: PMC3384183.
    38. Bajsarowicz K, Ahn M, Ackerman L, Dearmond BN, Carlson G, DeArmond SJ. A brain aggregate model gives new insights into the pathobiology and treatment of prion diseases. J Neuropathol Exp Neurol. 2012 May; 71(5):449-66. PMID: 22507918.
      View in: PubMed
    39. Spires-Jones TL, Fox LM, Rozkalne A, Pitstick R, Carlson G, Kazantsev AG. Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia. Front Pharmacol. 2012; 3:42. PMID: 22416232; PMCID: PMC3298895.
    40. de Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson G, Spires-Jones TL, Hyman BT. Propagation of tau pathology in a model of early Alzheimer's disease. Neuron. 2012 Feb 23; 73(4):685-97. PMID: 22365544; PMCID: PMC3292759.
    41. Westaway D, Genovesi S, Daude N, Brown R, Lau A, Lee I, Mays CE, Coomaraswamy J, Canine B, Pitstick R, Herbst A, Yang J, Ko KW, Schmitt-Ulms G, Dearmond SJ, McKenzie D, Hood L, Carlson G. Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation. PLoS Pathog. 2011 Nov; 7(11):e1002391. PMID: 22114562; PMCID: PMC3219720.
    42. Kopeikina KJ, Carlson G, Pitstick R, Ludvigson AE, Peters A, Luebke JI, Koffie RM, Frosch MP, Hyman BT, Spires-Jones TL. Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. Am J Pathol. 2011 Oct; 179(4):2071-82. PMID: 21854751; PMCID: PMC3181340.
    43. Lan X, Kiyota T, Hanamsagar R, Huang Y, Andrews S, Peng H, Zheng JC, Swindells S, Carlson G, Ikezu T. The effect of HIV protease inhibitors on amyloid-ß peptide degradation and synthesis in human cells and Alzheimer's disease animal model. J Neuroimmune Pharmacol. 2012 Jun; 7(2):412-23. PMID: 21826404; PMCID: PMC3223330.
    44. Fox LM, William CM, Adamowicz DH, Pitstick R, Carlson G, Spires-Jones TL, Hyman BT. Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model. J Neuropathol Exp Neurol. 2011 Jul; 70(7):588-95. PMID: 21666499; PMCID: PMC3118928.
    45. Park L, Wang G, Zhou P, Zhou J, Pitstick R, Previti ML, Younkin L, Younkin SG, Van Nostrand WE, Cho S, Anrather J, Carlson G, Iadecola C. Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):5063-8. PMID: 21383152; PMCID: PMC3064396.
    46. Kim Y, Kim TK, Kim Y, Yoo J, You S, Lee I, Carlson G, Hood L, Choi S, Hwang D. Principal network analysis: identification of subnetworks representing major dynamics using gene expression data. Bioinformatics. 2011 Feb 01; 27(3):391-8. PMID: 21193522; PMCID: PMC3031040.
    47. Hoover BR, Reed MN, Su J, Penrod RD, Kotilinek LA, Grant MK, Pitstick R, Carlson G, Lanier LM, Yuan LL, Ashe KH, Liao D. Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron. 2010 Dec 22; 68(6):1067-81. PMID: 21172610; PMCID: PMC3026458.
    48. Hnasko R, Serban AV, Carlson G, Prusiner SB, Stanker LH. Generation of antisera to purified prions in lipid rafts. Prion. 2010 Apr-Jun; 4(2):94-104. PMID: 20647769; PMCID: PMC2933057.
    49. de Calignon A, Fox LM, Pitstick R, Carlson G, Bacskai BJ, Spires-Jones TL, Hyman BT. Caspase activation precedes and leads to tangles. Nature. 2010 Apr 22; 464(7292):1201-4. PMID: 20357768; PMCID: PMC3091360.
    50. Wang K, Lee I, Carlson G, Hood L, Galas D. Systems biology and the discovery of diagnostic biomarkers. Dis Markers. 2010; 28(4):199-207. PMID: 20534905; PMCID: PMC3021550.
    51. Mauer MP, Herdt-Losavio ML, Carlson G. Asthma and lower respiratory symptoms in New York State employees who responded to the World Trade Center disaster. Int Arch Occup Environ Health. 2010 Jan; 83(1):21-7. PMID: 19890659.
      View in: PubMed
    52. Watts JC, Huo H, Bai Y, Ehsani S, Jeon AH, Won AH, Shi T, Daude N, Lau A, Young R, Xu L, Carlson G, Williams D, Westaway D, Schmitt-Ulms G. Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones. PLoS Pathog. 2009 Oct; 5(10):e1000608. PMID: 19798432; PMCID: PMC2749441.
    53. Gehlenborg N, Hwang D, Lee IY, Yoo H, Baxter D, Petritis B, Pitstick R, Marzolf B, Dearmond SJ, Carlson G, Hood L. The Prion Disease Database: a comprehensive transcriptome resource for systems biology research in prion diseases. Database (Oxford). 2009; 2009:bap011. PMID: 20157484.
      View in: PubMed
    54. Babij P, Roudier M, Graves T, Han CY, Chhoa M, Li CM, Juan T, Morony S, Grisanti M, Li X, Yu L, Dwyer D, Lloyd DJ, Bass MB, Richards WG, Ebeling C, Amato J, Carlson G. New variants in the Enpp1 and Ptpn6 genes cause low BMD, crystal-related arthropathy, and vascular calcification. J Bone Miner Res. 2009 Sep; 24(9):1552-64. PMID: 19419305.
      View in: PubMed
    55. de Calignon A, Spires-Jones TL, Pitstick R, Carlson G, Hyman BT. Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy. J Neuropathol Exp Neurol. 2009 Jul; 68(7):757-61. PMID: 19535996; PMCID: PMC2756569.
    56. Hwang D, Lee IY, Yoo H, Gehlenborg N, Cho JH, Petritis B, Baxter D, Pitstick R, Young R, Spicer D, Price ND, Hohmann JG, Dearmond SJ, Carlson G, Hood LE. A systems approach to prion disease. Mol Syst Biol. 2009; 5:252. PMID: 19308092; PMCID: PMC2671916.
    57. Juan T, Véniant MM, Helmering J, Babij P, Baker DM, Damore MA, Bass MB, Gyuris T, Chhoa M, Li CM, Ebeling C, Amato J, Carlson G, Lloyd DJ. Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice. J Lipid Res. 2009 Mar; 50(3):534-45. PMID: 18974039.
      View in: PubMed
    58. Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz J, Epstein CJ, Cruz TD, Kuziel WA, Maeda N, Sap J, Ashe KH, Carlson G, Tesseur I, Wyss-Coray T, Mucke L, Weisgraber KH, Mahley RW, Cohen FE, Prusiner SB. Genes contributing to prion pathogenesis. J Gen Virol. 2008 Jul; 89(Pt 7):1777-88. PMID: 18559949; PMCID: PMC2828448.
    59. Kumar R, McClain D, Young R, Carlson G. Cholesterol transporter ATP-binding cassette A1 (ABCA1) is elevated in prion disease and affects PrPC and PrPSc concentrations in cultured cells. J Gen Virol. 2008 Jun; 89(Pt 6):1525-32. PMID: 18474570; PMCID: PMC2706533.
    60. Herdt-Losavio ML, Lin S, Druschel CM, Hwang SA, Mauer MP, Carlson G. The risk of having a low birth weight or preterm infant among cosmetologists in New York State. Matern Child Health J. 2009 Jan; 13(1):90-7. PMID: 18297381.
      View in: PubMed
    61. Herdt-Losavio ML, Mauer MP, Carlson G. Development of an exposure assessment method for epidemiological studies of New York State personnel who responded to the World Trade Center disaster. Ann Occup Hyg. 2008 Mar; 52(2):83-93. PMID: 18272906.
      View in: PubMed
    62. Spires-Jones TL, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek JD, Jones PB, Bacskai BJ, Feany MB, Carlson G, Ashe KH, Lewis J, Hyman BT. In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. J Neurosci. 2008 Jan 23; 28(4):862-7. PMID: 18216194.
      View in: PubMed
    63. Park L, Zhou P, Pitstick R, Capone C, Anrather J, Norris EH, Younkin L, Younkin S, Carlson G, McEwen BS, Iadecola C. Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein. Proc Natl Acad Sci U S A. 2008 Jan 29; 105(4):1347-52. PMID: 18202172; PMCID: PMC2234141.
    64. Watts JC, Drisaldi B, Ng V, Yang J, Strome B, Horne P, Sy MS, Yoong L, Young R, Mastrangelo P, Bergeron C, Fraser PE, Carlson G, Mount HT, Schmitt-Ulms G, Westaway D. The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections. EMBO J. 2007 Sep 05; 26(17):4038-50. PMID: 17703189; PMCID: PMC1950727.
    65. Murakami T, Paitel E, Kawarabayashi T, Ikeda M, Chishti MA, Janus C, Matsubara E, Sasaki A, Kawarai T, Phinney AL, Harigaya Y, Horne P, Egashira N, Mishima K, Hanna A, Yang J, Iwasaki K, Takahashi M, Fujiwara M, Ishiguro K, Bergeron C, Carlson G, Abe K, Westaway D, St George-Hyslop P, Shoji M. Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation. Am J Pathol. 2006 Oct; 169(4):1365-75. PMID: 17003492; PMCID: PMC1698843.
    66. Spires TL, Orne JD, SantaCruz K, Pitstick R, Carlson G, Ashe KH, Hyman BT. Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy. Am J Pathol. 2006 May; 168(5):1598-607. PMID: 16651626; PMCID: PMC1606598.
    67. Giri RK, Young R, Pitstick R, DeArmond SJ, Prusiner SB, Carlson G. Prion infection of mouse neurospheres. Proc Natl Acad Sci U S A. 2006 Mar 07; 103(10):3875-80. PMID: 16495413; PMCID: PMC1533787.
    68. Ramsden M, Kotilinek L, Forster C, Paulson J, McGowan E, SantaCruz K, Guimaraes A, Yue M, Lewis J, Carlson G, Hutton M, Ashe KH. Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). J Neurosci. 2005 Nov 16; 25(46):10637-47. PMID: 16291936.
      View in: PubMed
    69. Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St George-Hyslop P, Carlson G, Westaway D. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Proc Natl Acad Sci U S A. 2005 Jun 21; 102(25):8972-7. PMID: 15951428; PMCID: PMC1149500.
    70. Park L, Anrather J, Zhou P, Frys K, Pitstick R, Younkin S, Carlson G, Iadecola C. NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. J Neurosci. 2005 Feb 16; 25(7):1769-77. PMID: 15716413.
      View in: PubMed
    71. Clark AT, Goldowitz D, Takahashi JS, Vitaterna MH, Siepka SM, Peters LL, Frankel WN, Carlson G, Rossant J, Nadeau JH, Justice MJ. Implementing large-scale ENU mutagenesis screens in North America. Genetica. 2004 Sep; 122(1):51-64. PMID: 15619961; PMCID: PMC3774779.
    72. Krezowski J, Knudson D, Ebeling C, Pitstick R, Giri RK, Schenk D, Westaway D, Younkin L, Younkin SG, Ashe KH, Carlson G. Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression. Hum Mol Genet. 2004 Sep 15; 13(18):1989-97. PMID: 15254013.
      View in: PubMed
    73. Li F, Calingasan NY, Yu F, Mauck WM, Toidze M, Almeida CG, Takahashi RH, Carlson G, Flint Beal M, Lin MT, Gouras GK. Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice. J Neurochem. 2004 Jun; 89(5):1308-12. PMID: 15147524.
      View in: PubMed
    74. Park L, Anrather J, Forster C, Kazama K, Carlson G, Iadecola C. Abeta-induced vascular oxidative stress and attenuation of functional hyperemia in mouse somatosensory cortex. J Cereb Blood Flow Metab. 2004 Mar; 24(3):334-42. PMID: 15091114.
      View in: PubMed
    75. Phinney AL, Drisaldi B, Schmidt SD, Lugowski S, Coronado V, Liang Y, Horne P, Yang J, Sekoulidis J, Coomaraswamy J, Chishti MA, Cox DW, Mathews PM, Nixon RA, Carlson G, St George-Hyslop P, Westaway D. In vivo reduction of amyloid-beta by a mutant copper transporter. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14193-8. PMID: 14617772; PMCID: PMC283568.
    76. Carlson G. A welcoming environment for amyloid plaques. Nat Neurosci. 2003 Apr; 6(4):328-30. PMID: 12658277.
      View in: PubMed
    77. Carlson G. Postexposure prophylaxis against transmissible spongiform encephalopathies: CpG oligodeoxynucleotides in mice. Lancet. 2002 Jul 20; 360(9328):184. PMID: 12133649.
      View in: PubMed
    78. Niwa K, Kazama K, Younkin L, Younkin SG, Carlson G, Iadecola C. Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein. Am J Physiol Heart Circ Physiol. 2002 Jul; 283(1):H315-23. PMID: 12063304.
      View in: PubMed
    79. Westaway D, Carlson G. Mammalian prion proteins: enigma, variation and vaccination. Trends Biochem Sci. 2002 Jun; 27(6):301-7. PMID: 12069790.
      View in: PubMed
    80. Westerman MA, Cooper-Blacketer D, Mariash A, Kotilinek L, Kawarabayashi T, Younkin LH, Carlson G, Younkin SG, Ashe KH. The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J Neurosci. 2002 Mar 01; 22(5):1858-67. PMID: 11880515.
      View in: PubMed
    81. Niwa K, Kazama K, Younkin SG, Carlson G, Iadecola C. Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein. Neurobiol Dis. 2002 Feb; 9(1):61-8. PMID: 11848685.
      View in: PubMed
    82. Yehiely F, Bamborough P, Da Costa M, Perry BJ, Thinakaran G, Cohen FE, Carlson G, Prusiner SB. Identification of candidate proteins binding to prion protein. Neurobiol Dis. 1997; 3(4):339-55. PMID: 9173930.
      View in: PubMed
    83. Westaway D, Carlson G, Prusiner SB. On safari with PrP: prion diseases of animals. Trends Microbiol. 1995 Apr; 3(4):141-7. PMID: 7613755.
      View in: PubMed
    84. Westaway D, Cooper C, Turner S, Da Costa M, Carlson G, Prusiner SB. Structure and polymorphism of the mouse prion protein gene. Proc Natl Acad Sci U S A. 1994 Jul 05; 91(14):6418-22. PMID: 7912827; PMCID: PMC44213.
    85. Westaway D, DeArmond SJ, Cayetano-Canlas J, Groth D, Foster D, Yang SL, Torchia M, Carlson G, Prusiner SB. Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins. Cell. 1994 Jan 14; 76(1):117-29. PMID: 8287472.
      View in: PubMed
    86. Prusiner SB, Scott M, Foster D, Pan KM, Groth D, Mirenda C, Torchia M, Yang SL, Serban D, Carlson G. Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication. Cell. 1990 Nov 16; 63(4):673-86. PMID: 1977523.
      View in: PubMed
    87. Scott M, Foster D, Mirenda C, Serban D, Coufal F, Wälchli M, Torchia M, Groth D, Carlson G, DeArmond SJ, Westaway D, Prusiner SB. Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques. Cell. 1989 Dec 01; 59(5):847-57. PMID: 2574076.
      View in: PubMed
    88. Gabizon R, McKinley MP, Groth D, Westaway D, DeArmond SJ, Carlson G, Prusiner SB. Immunoaffinity purification and neutralization of scrapie prions. Prog Clin Biol Res. 1989; 317:583-600. PMID: 2574871.
      View in: PubMed
    89. Westaway D, Goodman PA, Mirenda CA, McKinley MP, Carlson G, Prusiner SB. Distinct prion proteins in short and long scrapie incubation period mice. Cell. 1987 Nov 20; 51(4):651-62. PMID: 2890436.
      View in: PubMed
    George's Networks
    Derived automatically from this person's publications.
    People in Profiles who have published with this person.
    Related Authors
    People who share related concepts with this person.
    Back to TOP