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Gerold Grodsky, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentDiabetes Center
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-5112
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.1955 Graduate Division (Biochemistry)
    Collapse Awards and Honors
    US Midwestern Islet Group2013Paul Lacy Prize
    UCSF2010Creation of the Gerold Grodsky, PhD Chair in Diabetes Research
    UCSF Diabetes Center2009Lifetime Achievement Award
    US Western Metabolic Group1990Williams and Levine Award
    National Institutes of Health1986Merit Award
    Juvenile Diabetes Research Foundation1984David Rumbaugh Scientific Award

    Collapse Overview 
    Collapse Overview
    Dr. Grodsky is currently a consultant to laboratories in the Diabetes Center. He was the developer of the first precipitating radio immunoassay (insulin). His group published over 200 papers on the mechanisms involved in the synthesis, storage and secretion of insulin, with emphasis on the kinetics and quantitative relationships of these mechanisms. From these studies came the description of the fast and slow phases of insulin release and the hypothesis that insulin is stored in compartments of differing availability for release. The rapid phase of insulin release was shown to be vital in the maintenance of glucose homeostasis and is being utilized in the design of the closed-loop artificial pancreas, faster acting beta-cell secretagogues, and fast absorbing insulin preparations.

    Other areas of research activity includes the demonstration of insulin-induced auto antibodies and their contribution to beta-cell destruction.

    Dr. Grodsky taught for 48 years focusing on regulation of glucose and energy Metabolism, insulin and diabetes. He served as Research Chairman of the Advisory Board for Diabetes to the Secretary of Health and on the editorial boards of numerous journals; he was the Founding Advisory Editor of the journal, "Diabetes Technology and Therapeutics" and is the Advisory Editor of the Journal of Diabetes Science and Technology. Since 1994, the Juvenile Diabetes Foundation, International has given an Annual Gerold Grodsky Award for basic research in diabetes.


    Collapse Research 
    Collapse Research Activities and Funding
    INSULIN SYNTHESIS, STORAGE, AND SECRETION IN VITRO
    NIH/NIDDK R37DK001410Jan 1, 1976 - Dec 31, 1993
    Role: Principal Investigator
    INSULIN AND GLUCAGON SYNTHESIS AND SECRETION IN VITRO
    NIH/NIADDK R01AM001410Jan 1, 1976 - Dec 31, 1985
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Steil GM, Grodsky GM. The artificial pancreas: is it important to understand how the ß cell controls blood glucose? J Diabetes Sci Technol. 2013 Sep 01; 7(5):1359-69. PMID: 24124965; PMCID: PMC3876382.
    2. Bonner-Weir S, Grodsky G. Assessment of human islet preparations to be used for islet expansion, survival, or transplant. Diabetes Technol Ther. 2004 Aug; 6(4):493-4. PMID: 15321004.
      View in: PubMed
    3. Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes. 2003 Jan; 52(1):1-8. PMID: 12502486.
      View in: PubMed
    4. Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev. 2002 Oct; 23(5):599-622. PMID: 12372842.
      View in: PubMed