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Gilad Doitsh, PhD

Title(s)Specialist-Pediatric Immunology, Microbiology and Immunology
SchoolSchool of Medicine
Phone415-476-9326
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    Collapse Biography 
    Collapse Awards and Honors
    UCSF2014  - 2015CFAR Early Career Investigator Award for Excellence in Basic Research.
    The Gladstone Institutes, UCSF2010  - 2011The Gladstone Institute of Virology and Immunology Award for Scientific Excellence

    Collapse Overview 

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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Luo X, Herzig E, Doitsh G, Grimmett ZW, Muñoz-Arias I, Greene WC. HIV-2 depletes CD4 T cells through pyroptosis despite Vpx-dependent degradation of SAMHD1. J Virol. 2019 Oct 02. PMID: 31578293.
      View in: PubMed
    2. Pulugulla SH, Packard TA, Galloway NLK, Grimmett ZW, Doitsh G, Adamik J, Galson DL, Greene WC, Auron PE. Distinct mechanisms regulate IL1B gene transcription in lymphoid CD4 T cells and monocytes. Cytokine. 2018 11; 111:373-381. PMID: 30300855.
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    3. Lydie Trautmann, Kimberly M. Nelson, Joyce P. Yang, Yamile Molina, Jane M. Simoni, Venkat R. K. Yedavalli, Kuan-Teh Jeang, Anne Gatignol, Huan-You Wang, Ida Wong-Sefidan, Erin Reid, Junette McWilliams, Amy Knowlton, Asier Sáez-Cirión, Laurent Hocqueloux, Christine Rouzioux, Amanda D. Castel, Alice Cates, Christina Fiske, Richard F. Little, Stefania Pittaluga, Kieron Dunleavy, Jean-Louis Excler, Merlin L. Robb, Jerome H. Kim, Nelson L. Michael, Carla J. Chibwesha, Lisa Rahangdale, Benjamin H. Chi, Grace C. John-Stewart, Cheryl Baxter, Quarraisha Abdool Karim, Safiya George Dalmida, Drenna Waldrop-Valverde, Rashunda Lewis, Nicole Crepaz, Cynthia M. Lyles, Mary T. Hickey, Sherry Deren, Mary Vogler, Karen Beckerman, Giovanna Tosato, Paola Cinque, Simonetta Gerevini, Richard W. Price, Cecile Delille Lahiri, Jeffrey Lennox, Ighovwerha Ofotokun, Gilad Doitsh. PD-1. Encyclopedia of AIDS. 2018 Jan 1; 1627-1632.
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    4. Gilad Doitsh. Pyroptosis in HIV Infection: HIV Offense Meets a Fiery Host Defense. Encyclopedia of AIDS. 2018 Jan 1; 1774-1782.
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    5. Doitsh G, Greene WC. Dissecting How CD4 T Cells Are Lost During HIV Infection. Cell Host Microbe. 2016 Mar 09; 19(3):280-91. PMID: 26962940.
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    6. Muñoz-Arias I, Doitsh G, Yang Z, Sowinski S, Ruelas D, Greene WC. Blood-Derived CD4 T Cells Naturally Resist Pyroptosis during Abortive HIV-1 Infection. Cell Host Microbe. 2015 Oct 14; 18(4):463-70. PMID: 26468749.
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    7. Galloway NL, Doitsh G, Monroe KM, Yang Z, Muñoz-Arias I, Levy DN, Greene WC. Cell-to-Cell Transmission of HIV-1 Is Required to Trigger Pyroptotic Death of Lymphoid-Tissue-Derived CD4 T Cells. Cell Rep. 2015 Sep 08; 12(10):1555-1563. PMID: 26321639.
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    8. Gilad Doitsh. Pyroptosis in HIV Infection: HIV Offense Meets a Fiery Host Defense. Encyclopedia of AIDS. 2015 Jan 1; 1-9.
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    9. Warner Greene, Nicole Galloway, Gilad Doitsh, Xin Geng, Zhiyuan Yang, Kathryn Monroe, Isa Munoz-Arias. F-103 Cell-to-cell transmission of HIV-1 is required to trigger pyroptotic death of CD4 T cells in lymphoid tissue. JAIDS Journal of Acquired Immune Deficiency Syndromes. 2014 Nov 1; 67(&NA;):63.
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    10. Geng X, Doitsh G, Yang Z, Galloway NL, Greene WC. Efficient delivery of lentiviral vectors into resting human CD4 T cells. Gene Ther. 2014 Apr; 21(4):444-9. PMID: 24572792.
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    11. Gilad Doitsh, Marielle Cavrois, Kara G. Lassen, Orlando Zepeda, Zhiyuan Yang, Mario L. Santiago, Andrew M. Hebbeler, Warner C. Greene. Abortive HIV Infection Mediates CD4 T Cell Depletion and Inflammation in Human Lymphoid Tissue. Cell. 2014 Feb 1; 156(5):1112-1113.
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    12. Doitsh G, Galloway NL, Geng X, Yang Z, Monroe KM, Zepeda O, Hunt PW, Hatano H, Sowinski S, Muñoz-Arias I, Greene WC. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature. 2014 Jan 23; 505(7484):509-14. PMID: 24356306.
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    13. Monroe KM, Yang Z, Johnson JR, Geng X, Doitsh G, Krogan NJ, Greene WC. IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV. Science. 2014 Jan 24; 343(6169):428-32. PMID: 24356113.
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    14. . Sargeant, S. Deverasetty, Y. Luo, A. Villahoz-Baleta, S. Zobrist, V. Rathnayake, J. Russo, M. Muesing, M. Schiller, R. Andrabi, R. Kumar, M. Bala, A. Nair, A. Biswas, N. Wig, P. Kumar, K. Luthra, N. Gonzalez, K. McKee, E. Yuste, J.R. Mascola, J. Alcamí, L. Vojnov, M. Martins, A. Bean, M. Veloso de Santana, J. Sacha, N. Wilson, M. Bonaldo, R. Galler, M. Stevenson, D. Watkins, M. Aziz, M. Mata, F. Mahmood, H. Durkin, C. Liu, R. Greenblatt, M. Nowicki, E. Golub, K. Anastos, A. French, L. Baum, V.S. Wacleche, N. Chomont, A. Gosselin, P. Monteiro, M. Goupil, H. Kared, C. Tremblay, N. Bernard, M.-R. Boulassel, J.-P. Routy, P. Ancuta, J. Jadlowsky, C. Baiduc, M. Richardson, A. Bennett, B. Jakobsen, J.L. Riley, B. Vingert, D. Benati, O. Lambotte, P. de Truchis, L. Slama, P. Jeannin, S. Perez-Patrigeon, F. Boufassa, W.W. Kwok, F. Lemaître, J.-F. Delfraissy, J. Thèze, L.A. Chakrabarti, M. French, R. Center, K. Wilson, I. Fleyfel, S. Fernandez, A. Kelleher, P. An, J. Goedert, S. Donfield, S. Buchbinder, G. Kirk, R. Detels, C. Winkler, J. Lajoie, J. Juno, A. Burgener, S. Rahman, K. Mogk, C. Wachihi, J. Mwanjewe, F.A. Plummer, J. Kimani, T.B. Ball, K.R. Fowke, A. Burgener, J. Lajoie, C. Wachihi, J. Kimani, K. Fowke, F.A. Plummer, T.B. Ball, T.N. Dieye, A. Chentouffi, M. Camara, S. Sarr, M.V. Tran, M. Seydi, G. Dasgupta, M. Fall, G. Daneau, P.A. Diaw, L. Kestens, P.S. Sow, S. Mboup, L. Benmohamed, D.M. Asmuth, Z.-M. Ma, A. Albanese, S. Devaraj, E. Hodzic, J.-C. Garcia, T.H. Knight, N.M. Flynn, S. Mann, T. Yotter, E. Tsuchida, C.J. Miller, S. Pallikkuth, L. Micci, Z. Ende, R. Iriele, B. Cervasi, J. Else, G. Silvestri, F. Villinger, S. Pahwa, M. Paiardini, S. Solomon, K.G. Murugavel, R. Vignesh, D. Bella, R. Shoba, S. Poongulali, N. Kumarasamy, A. Landay, S.S. Solomon, C.R. Swathirajan, P. Balakrishnan, S. Cu-Uvin, K.H. Mayer, B.L. Shacklett, C.S. Palmer, J. Zhou, S. Saleh, L. Lam, A. Hearps, A. Maisa, C. Pereira, S. Lewin, A. Jaworowski, J.M. McCune, S. Crowe, G. Doitsh, N. Galloway, K. Monroe, Z. Yang, O. Zepeda, W.C. Greene, M. Patel, M.-A. Jenabian, B. Lebouché, M.-J. Brouillette, C. Tremblay, I. Kema, M.-R. Boulassel, J.-P. Routy, F. Al-Ghazawi, E. Faller, P. Parmar, J. Kakal, P. MacPherson, F. Al-Ghazawi, P. Parmar, E. Faller, S. Sugden, N. Sant, P. MacPherson, C. Vinton, J. Brenchley, B. Tabb, X.P. Hao, V.M. Hirsch, M. Paiardini, J. Lifson, G. Silvestri, J.D. Estes, F. Bushman, S. Sherrill-Mix, K. Ocwieja, R. Mukherjee, M. Brown, J. Chin, R. Custers-Allen, P. David, J. Olson, K. Travers, E. Schadt, M. Sánchez del Cojo, M.R. López-Huertas, E. Mateos, M. Coiras, J. Alcamí, G. Sampey, R. Van Duyne, I. Guendel, E. Gregg, N. Shafagati, M. Tyagi, R. Easely, Z. Klase, F. Romerio, M. Iglesias-Ussel, S. Nekhai, K. Kehn-Hall, F. Kashanchi, N. Kumar, V. Evans, S. Saleh, C.F. Pereira, P. Ellenberg, P.U. Cameron, S.R. Lewin, L. Gray, D. Cowley, E. Crespan, C. Welsh, C. Mackenzie, P. Gorry, S. Wesselingh, M. Churchill, M. Iglesias-Ussel, L. Marchionni, F. Romerio, S. Weber, H. Burger, K. Kemal, B. Weiser, K. Korn, K. Anastos, W. Doerfler, S. Saleh, D. Vatakis, P. Cameron, A. Harman, A. Cunningham, S. Lewin, D. Ma, A. Cillo, C.L. Xu, J. Kristoff, J. Fang, G. Haret-Richter, J. Mellors, I. Pandrea, C. Apetrei, B. Trinité, E. Ohlson, S. Rana, J. Alster, D.N. Levy, A.F.B. Victoriano, Y. Hibi, N. Tan Gana, K. Asamitsu, T. Okamoto, M. Marsden, M. Kovochich, N. Suree, S. Shimizu, R. Mehta, R. Cortado, G. Bristol, D.S. An, J. Zack, N. Madrid-Elena, B. Hernandez-Novoa, M. Lamas, L. Garcia-Bermejo, S. Moreno, T. Ruel, J. Achan, W. Huang, H. Cao, P. Li, L.A. Eller, M. Killian, E. Sinclair, E. Charlebois, D.V. Havlir, J. Wong, T.J. Henrich, G. Sciaranghella, J.Z. Li, S. Gallien, V. Ho, A.S. Lacasce, D.R. Kuritzkes, J. Lifson, G. Del Prete, R. Kiser, C.M. Trubey, J. Smedley, V. Coalter, K. Oswald, R. Shoemaker, R. Fast, Y. Li, A. Lara, A. Wiles, R. Wiles, R. Macallister, R. Sanchez, J. Wai, C. Tan, B. Keele, J. Estes, M. Piatakjr, D. Hazuda, J. Symons, S. Deeks. Track A Basic Science. Journal of the International AIDS Society. 2012 Oct 24; 15(Suppl 3):18438-01.
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    15. Gilad Doitsh, Orlando Zepeda, Nicole Galloway, Isa Arias, Warner C. Greene. 145 Pyroptosis and HIV-Induced CD4 T Cell Death. JAIDS Journal of Acquired Immune Deficiency Syndromes. 2012 Apr 1; 59(&NA;):61.
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    16. Gilad Doitsh, Marielle Cavrois, Kara Lassen, Orlando Zepeda, Zhiyuan Yang, Mario Santiago, Andrew M Hebbeler, Warner C Greene. 113 Murder on the HIV Express: Insights into How CD4 T Cells Are Killed in Lymphoid Tissues. JAIDS Journal of Acquired Immune Deficiency Syndromes. 2011 Apr 1; 56:45.
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    17. Doitsh G, Cavrois M, Lassen KG, Zepeda O, Yang Z, Santiago ML, Hebbeler AM, Greene WC. Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue. Cell. 2010 Nov 24; 143(5):789-801. PMID: 21111238.
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    18. Gilad Doitsh, Jason Kreisberg, Warner Greene. Mechanisms of HIV-Infected vs. Uninfected T Cell Killing. Cell Death During HIV Infection. 2005 Nov 29; 207-228.
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    19. Doitsh G, Shaul Y. Enhancer I predominance in hepatitis B virus gene expression. Mol Cell Biol. 2004 Feb; 24(4):1799-808. PMID: 14749394.
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    20. Doitsh G, Shaul Y. A long HBV transcript encoding pX is inefficiently exported from the nucleus. Virology. 2003 May 10; 309(2):339-49. PMID: 12758180.
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    21. Shamay M, Barak O, Doitsh G, Ben-Dor I, Shaul Y. Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription. J Biol Chem. 2002 Mar 22; 277(12):9982-8. PMID: 11788598.
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    22. Doitsh G, Shaul Y. HBV transcription repression in response to genotoxic stress is p53-dependent and abrogated by pX. Oncogene. 1999 Dec 09; 18(52):7506-13. PMID: 10602509.
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    23. Haviv I, Shamay M, Doitsh G, Shaul Y. Hepatitis B virus pX targets TFIIB in transcription coactivation. Mol Cell Biol. 1998 Mar; 18(3):1562-9. PMID: 9488473.
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    24. Ori A, Zauberman A, Doitsh G, Paran N, Oren M, Shaul Y. p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53. EMBO J. 1998 Jan 15; 17(2):544-53. PMID: 9430645.
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