 Gilad Doitsh, PhD
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| Title(s) | Specialist-Pediatric Immunology, Surgery |
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| School | School of Medicine |
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| Phone | 415-476-9326 |
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| vCard | Download vCard |
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 Biography | UCSF | 2014
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| 2015 | CFAR Early Career Investigator Award for Excellence in Basic Research. | | The Gladstone Institutes, UCSF | 2010
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| 2011 | The Gladstone Institute of Virology and Immunology Award for Scientific Excellence |
Overview Maternal-Fetal Immune Mechanisms, Autoimmune Regulator (AIRE), Fetomaternal tolerance, Thymic selection, Central toleranc, Peripheral tolerance, Fetal allograft, Induced Treg cells, Trophoblast, Microchimerism, Direct/Indirect allorecognition, Placenta, Decidua, Pre-tem Labor, Mixed Lymphocyte Reaction (MLR), Immune Checkpoints, HIV Pathogenesis, Innate Immunity, Inflammation, Abortive HIV Infection, PAMPS and PRRs, Cell-to-cell transmission of viruses, Lymphoid Tissues, CD4 T cells
ORNG Applications Bibliographic
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Doitsh G, Greene WC. Dissecting How CD4 T Cells Are Lost During HIV Infection. Cell Host Microbe. 2016 Mar 09; 19(3):280-91. PMID: 26962940; PMCID: PMC4835240 [Available on 03/09/17].
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Muñoz-Arias I, Doitsh G, Yang Z, Sowinski S, Ruelas D, Greene WC. Blood-Derived CD4 T Cells Naturally Resist Pyroptosis during Abortive HIV-1 Infection. Cell Host Microbe. 2015 Oct 14; 18(4):463-70. PMID: 26468749; PMCID: PMC4627664 [Available on 10/14/16].
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Galloway NL, Doitsh G, Monroe KM, Yang Z, Muñoz-Arias I, Levy DN, Greene WC. Cell-to-Cell Transmission of HIV-1 Is Required to Trigger Pyroptotic Death of Lymphoid-Tissue-Derived CD4 T Cells. Cell Rep. 2015 Sep 08; 12(10):1555-1563. PMID: 26321639; PMCID: PMC4565731.
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Geng X, Doitsh G, Yang Z, Galloway NL, Greene WC. Efficient delivery of lentiviral vectors into resting human CD4 T cells. Gene Ther. 2014 Apr; 21(4):444-9. PMID: 24572792; PMCID: PMC4006095.
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Doitsh G, Galloway NL, Geng X, Yang Z, Monroe KM, Zepeda O, Hunt PW, Hatano H, Sowinski S, Muñoz-Arias I, Greene WC. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature. 2014 Jan 23; 505(7484):509-14. PMID: 24356306; PMCID: PMC4047036.
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Monroe KM, Yang Z, Johnson JR, Geng X, Doitsh G, Krogan NJ, Greene WC. IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV. Science. 2014 Jan 24; 343(6169):428-32. PMID: 24356113.
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Doitsh G, Cavrois M, Lassen KG, Zepeda O, Yang Z, Santiago ML, Hebbeler AM, Greene WC. Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue. Cell. 2010 Nov 24; 143(5):789-801. PMID: 21111238.
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Doitsh G, Shaul Y. Enhancer I predominance in hepatitis B virus gene expression. Mol Cell Biol. 2004 Feb; 24(4):1799-808. PMID: 14749394; PMCID: PMC344184.
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Doitsh G, Shaul Y. A long HBV transcript encoding pX is inefficiently exported from the nucleus. Virology. 2003 May 10; 309(2):339-49. PMID: 12758180.
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Shamay M, Barak O, Doitsh G, Ben-Dor I, Shaul Y. Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription. J Biol Chem. 2002 Mar 22; 277(12):9982-8. PMID: 11788598.
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Doitsh G, Shaul Y. HBV transcription repression in response to genotoxic stress is p53-dependent and abrogated by pX. Oncogene. 1999 Dec 09; 18(52):7506-13. PMID: 10602509.
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Haviv I, Shamay M, Doitsh G, Shaul Y. Hepatitis B virus pX targets TFIIB in transcription coactivation. Mol Cell Biol. 1998 Mar; 18(3):1562-9. PMID: 9488473; PMCID: PMC108871.
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Ori A, Zauberman A, Doitsh G, Paran N, Oren M, Shaul Y. p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53. EMBO J. 1998 Jan 15; 17(2):544-53. PMID: 9430645; PMCID: PMC1170404.
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