Gregory Allen, MD, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSE, #308
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    Carnegie Mellon UniversityBS06/2004Chemical Engineering
    Stanford Medical SchoolMD/PHD06/2013Biochemistry, Medicine
    Johns Hopkins HospitalResidency06/2015Medicine
    Collapse Awards and Honors
    Carnegie Mellon2004Geoffrey D. Parfitt Award for Excellence in Research
    Jane Coffin Childs Memorial Fund2017  - 2020 Fellow
    NIH - NCI2021K08 Scholar
    Carnegie Mellon2001Alumni Award

    Collapse Overview 
    Collapse Overview
    Greg Allen, MD/PhD is a physician-scientist specializing in designing and translating next-generation immune cell therapies for solid tumors. He cares for patients with lung cancer at the Hellen Diller Cancer Center and runs a research laboratory at the Parker Institute for Cancer Immunotherapy.

    The Allen Lab is focused on developing and applying advanced synthetic biology tools to dissect the fundamental design principles of the immune system. We use synthetic receptors, cytokines, and secondary messengers to generate novel alternatively engineered tumor-immune eco-systems, which we then interrogate with high-dimensional tools. From this ground-up systems biology perspective we are attempting to rationally design engineered cells to tackle the most challenging diseases we face in the clinic.

    Collapse Research 
    Collapse Research Activities and Funding
    Developing novel CAR T cell designs using combinatorial antigen detection
    NIH K08CA259610Apr 1, 2021 - Mar 31, 2026
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. An immune-based tool platform for in vivo cell clearance. Life Sci Alliance. 2023 08; 6(8). Zhang J, Tsukui T, Wu X, Brito A, Trumble JM, Caraballo JC, Allen GM, Zavala-Solorio J, Zhang C, Paw J, Lim WA, Geng J, Kutskova Y, Freund A, Kolumam G, Sheppard D, Cohen RL. PMID: 37311583; PMCID: PMC10264967.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Synthetic cytokine circuits that drive T cells into immune-excluded tumors. Science. 2022 12 16; 378(6625):eaba1624. Allen GM, Frankel NW, Reddy NR, Bhargava HK, Yoshida MA, Stark SR, Purl M, Lee J, Yee JL, Yu W, Li AW, Garcia KC, El-Samad H, Roybal KT, Spitzer MH, Lim WA. PMID: 36520915; PMCID: PMC9970000.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    3. Rethinking cancer targeting strategies in the era of smart cell therapeutics. Nat Rev Cancer. 2022 12; 22(12):693-702. Allen GM, Lim WA. PMID: 36175644.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    4. Changes in older adults' life space during lung cancer treatment: A mixed methods cohort study. J Am Geriatr Soc. 2022 01; 70(1):136-149. Wong ML, Shi Y, Smith AK, Miaskowski C, Boscardin WJ, Cohen HJ, Lam V, Mazor M, Metzger L, Presley CJ, Williams GR, Loh KP, Ursem CJ, Friedlander TW, Blakely CM, Gubens MA, Allen G, Shumay D, Walter LC. PMID: 34611887; PMCID: PMC8742783.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    5. Precise T cell recognition programs designed by transcriptionally linking multiple receptors. Science. 2020 11 27; 370(6520):1099-1104. Williams JZ, Allen GM, Shah D, Sterin IS, Kim KH, Garcia VP, Shavey GE, Yu W, Puig-Saus C, Tsoi J, Ribas A, Roybal KT, Lim WA. PMID: 33243890; PMCID: PMC8054651.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    6. Discriminatory Power of Combinatorial Antigen Recognition in Cancer T Cell Therapies. Cell Syst. 2020 09 23; 11(3):215-228.e5. Dannenfelser R, Allen GM, VanderSluis B, Koegel AK, Levinson S, Stark SR, Yao V, Tadych A, Troyanskaya OG, Lim WA. PMID: 32916097; PMCID: PMC7814417.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    7. Cell Mechanics at the Rear Act to Steer the Direction of Cell Migration. Cell Syst. 2020 09 23; 11(3):286-299.e4. Allen GM, Lee KC, Barnhart EL, Tsuchida MA, Wilson CA, Gutierrez E, Groisman A, Theriot JA, Mogilner A. PMID: 32916096; PMCID: PMC7530145.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    8. Balance between cell-substrate adhesion and myosin contraction determines the frequency of motility initiation in fish keratocytes. Proc Natl Acad Sci U S A. 2015 Apr 21; 112(16):5045-50. Barnhart E, Lee KC, Allen GM, Theriot JA, Mogilner A. PMID: 25848042; PMCID: PMC4413303.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    9. Electrophoresis of cellular membrane components creates the directional cue guiding keratocyte galvanotaxis. Curr Biol. 2013 Apr 08; 23(7):560-8. Allen GM, Mogilner A, Theriot JA. PMID: 23541731; PMCID: PMC3718648.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    10. Myosin II contributes to cell-scale actin network treadmilling through network disassembly. Nature. 2010 May 20; 465(7296):373-7. Wilson CA, Tsuchida MA, Allen GM, Barnhart EL, Applegate KT, Yam PT, Ji L, Keren K, Danuser G, Theriot JA. PMID: 20485438; PMCID: PMC3662466.
      View in: PubMed   Mentions: 180     Fields:    Translation:AnimalsCells
    11. Bipedal locomotion in crawling cells. Biophys J. 2010 Mar 17; 98(6):933-42. Barnhart EL, Allen GM, Jülicher F, Theriot JA. PMID: 20303850; PMCID: PMC2849068.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    12. Mechanism of shape determination in motile cells. Nature. 2008 May 22; 453(7194):475-80. Keren K, Pincus Z, Allen GM, Barnhart EL, Marriott G, Mogilner A, Theriot JA. PMID: 18497816; PMCID: PMC2877812.
      View in: PubMed   Mentions: 280     Fields:    Translation:AnimalsCells
    13. Computational simulations of airflow in an in vitro model of the pediatric upper airways. J Biomech Eng. 2004 Oct; 126(5):604-13. Allen GM, Shortall BP, Gemci T, Corcoran TE, Chigier NA. PMID: 15648813.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
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