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Gregory Lee, PhD

Title(s)Specialist, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address1700 4th St
San Francisco CA 94158
Phone415-476-8147
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesPharmaceutical Chemistry
    University of British ColumbiaPostdoctoral FellowshipBiochemisty & Molecular Biology
    University of WashingtonPh.D.1999Chemistry
    University of California, DavisBachelor of Science1991Chemistry

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reply to "Pulmonary Sarcoidlike Granulomatosis". AJR Am J Roentgenol. 2020 08; 215(2):W26. Lee GM, Walker CM. PMID: 32749883.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Modulating protein-protein interaction networks in protein homeostasis. Curr Opin Chem Biol. 2019 06; 50:55-65. Zhong M, Lee GM, Sijbesma E, Ottmann C, Arkin MR. PMID: 30913483.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    3. Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease. ChemMedChem. 2016 Apr 19; 11(8):862-9. Gable JE, Lee GM, Acker TM, Hulce KR, Gonzalez ER, Schweigler P, Melkko S, Farady CJ, Craik CS. PMID: 26822284.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. Broad-spectrum allosteric inhibition of herpesvirus proteases. Biochemistry. 2014 Jul 22; 53(28):4648-60. Gable JE, Lee GM, Jaishankar P, Hearn BR, Waddling CA, Renslo AR, Craik CS. PMID: 24977643.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    5. Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy. Biochemistry. 2012 Dec 18; 51(50):10087-98. Lee GM, Balouch E, Goetz DH, Lazic A, McKerrow JH, Craik CS. PMID: 23181936.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    6. Enzyme inhibition by allosteric capture of an inactive conformation. J Mol Biol. 2011 Sep 02; 411(5):999-1016. Lee GM, Shahian T, Baharuddin A, Gable JE, Craik CS. PMID: 21723875.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    7. Remeasuring HEWL pK(a) values by NMR spectroscopy: methods, analysis, accuracy, and implications for theoretical pK(a) calculations. Proteins. 2011 Mar; 79(3):685-702. Webb H, Tynan-Connolly BM, Lee GM, Farrell D, O'Meara F, Søndergaard CR, Teilum K, Hewage C, McIntosh LP, Nielsen JE. PMID: 21287606.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    8. Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP. Proc Natl Acad Sci U S A. 2010 Jun 01; 107(22):10026-31. Nelson ML, Kang HS, Lee GM, Blaszczak AG, Lau DK, McIntosh LP, Graves BJ. PMID: 20534573.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    9. Inhibition of a viral enzyme by a small-molecule dimer disruptor. Nat Chem Biol. 2009 Sep; 5(9):640-6. Shahian T, Lee GM, Lazic A, Arnold LA, Velusamy P, Roels CM, Guy RK, Craik CS. PMID: 19633659.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    10. Solution state structures of human pancreatic amylin and pramlintide. Protein Eng Des Sel. 2009 Aug; 22(8):497-513. Cort JR, Liu Z, Lee GM, Huggins KN, Janes S, Prickett K, Andersen NH. PMID: 19596697.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    11. Trapping moving targets with small molecules. Science. 2009 Apr 10; 324(5924):213-5. Lee GM, Craik CS. PMID: 19359579.
      View in: PubMed   Mentions: 66     Fields:    Translation:Cells
    12. The affinity of Ets-1 for DNA is modulated by phosphorylation through transient interactions of an unstructured region. J Mol Biol. 2008 Oct 17; 382(4):1014-30. Lee GM, Pufall MA, Meeker CA, Kang HS, Graves BJ, McIntosh LP. PMID: 18692067.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    13. Peptide binding by a fragment of calmodulin composed of EF-hands 2 and 3. Biochemistry. 2007 Jul 24; 46(29):8525-36. Lakowski TM, Lee GM, Lelj-Garolla B, Okon M, Reid RE, McIntosh LP. PMID: 17595060.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    14. Calcium-induced folding of a fragment of calmodulin composed of EF-hands 2 and 3. Protein Sci. 2007 Jun; 16(6):1119-32. Lakowski TM, Lee GM, Okon M, Reid RE, McIntosh LP. PMID: 17473011.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    15. Compositions and methods for providing a Graded Response in a Protein. Patent WO/2007/005867. 2007. Graves BJ, Pufall MA, Lee GM, and McIntosh LP.View Publication.
    16. Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region. Science. 2005 Jul 01; 309(5731):142-5. Pufall MA, Lee GM, Nelson ML, Kang HS, Velyvis A, Kay LE, McIntosh LP, Graves BJ. PMID: 15994560.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    17. The structural and dynamic basis of Ets-1 DNA binding autoinhibition. J Biol Chem. 2005 Feb 25; 280(8):7088-99. Lee GM, Donaldson LW, Pufall MA, Kang HS, Pot I, Graves BJ, McIntosh LP. PMID: 15591056.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    18. Site-specific characterization of the association of xylooligosaccharides with the CBM13 lectin-like xylan binding domain from Streptomyces lividans xylanase 10A by NMR spectroscopy. Biochemistry. 2002 Apr 02; 41(13):4255-63. Schärpf M, Connelly GP, Lee GM, Boraston AB, Warren RA, McIntosh LP. PMID: 11914071.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    19. An NMR approach to structural proteomics. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):1825-30. Yee A, Chang X, Pineda-Lucena A, Wu B, Semesi A, Le B, Ramelot T, Lee GM, Bhattacharyya S, Gutierrez P, Denisov A, Lee CH, Cort JR, Kozlov G, Liao J, Finak G, Chen L, Wishart D, Lee W, McIntosh LP, Gehring K, Kennedy MA, Edwards AM, Arrowsmith CH. PMID: 11854485.
      View in: PubMed   Mentions: 71     Fields:    Translation:Cells
    20. NMR-based structure of the conserved protein MTH865 from the archaeon Methanobacterium thermoautotrophicum. J Biomol NMR. 2001 Sep; 21(1):63-6. Lee GM, Edwards AM, Arrowsmith CH, McIntosh LP. PMID: 11693569.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    21. Solution-State Conformational Analysis of Endothelin Analogs. University of Washington, Ph.D. Dissertation. 1999. Lee GM..
    22. Extracting Information from the Temperature Gradients of Polypeptide NH Chemical Shifts. 1. The Importance of Conformational Averaging. J. Am. Chem. Soc. 1997; 36(119):8547–8561. Andersen NH, Neidigh JW, Harris SM, Lee GM, Liu Z, and Tong H.View Publication.
    23. The Endothelin C-terminal Signal Fragment: Determinants of Conformational Equilibrium IN SITU and Detached. Prot. Pept. Lett. 1995; 4(1):215-222. Andersen NH, Chen C, and Lee GM.. View Publication.
    24. Does the solid-state structure of endothelin-1 provide insights concerning the solution-state conformational equilibrium? FEBS Lett. 1994 Nov 28; 355(2):140-6. Lee GM, Chen C, Marschner TM, Andersen NH. PMID: 7982487.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    25. ß-Structure in Human Amylin and 2 Designer ß-Peptides: CD and NMR Spectroscopic Comparisons Suggest Soluble ß-Oligomers and the Absence of Significant Populations of ß-Strand Dimers. Biochem. Biophys. Res. Commun. 1994; 3(204):1088–1095. Cort J, Liu Z, Lee G, Harris SM, Prickett KS, Gaeta LSL, and Andersen NH.View Publication.
    26. Configurational analysis of new furanosesquiterpenes from Dysidea herbacea. Assignment of absolute stereochemistry. Tetrahedron. 1994; 13(50):3879–3888. Searle PA, Jamal NM, Lee GM, and Moliski TF.View Publication.
    27. Herbaceamide, a chlorinated N-acyl amino ester from the marine sponge, Dysidea herbacea. Tetrahedron Lett. 1992; 50(33):7671–7674. Lee GM, and Molinski TF.View Publication.
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