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Guo-Yuan Yang

Title(s)Professor, Anesthesia
SchoolSchool of Medicine
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    Collapse Research 
    Collapse Research Activities and Funding
    BBB protection during treatment of transient ischemia
    NIH/NINDS R21NS050668Jul 15, 2005 - Apr 30, 2007
    Role: Principal Investigator
    Transgenic Murine Model of Brain Vascular Malformation
    NIH/NINDS R21NS045123Jun 1, 2003 - Nov 30, 2005
    Role: Principal Investigator
    Integrative Study of Brain Vascular Malformations
    NIH/NINDS P01NS044155Jul 1, 2002 - Mar 31, 2014
    Role: Co-Investigator
    MECHANISMS OF ACTION OF IL 1 IN ISCHEMIC BRAIN
    NIH/NINDS R01NS035089Jan 1, 1997 - Dec 31, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Liu J, Wang Y, Akamatsu Y, Lee CC, Stetler RA, Lawton MT, Yang GY. Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials. Prog Neurobiol. 2014 Apr; 115:138-56. PMID: 24291532; PMCID: PMC4295834.
      View in: PubMed, PubMed Central
    2. Su H, Yang GY. Treatment of focal brain ischemia with viral vector-mediated gene transfer. Methods Mol Biol. 2011; 686:429-46. PMID: 21082386.
      View in: PubMed
    3. Hao Q, Su H, Palmer D, Sun B, Gao P, Yang GY, Young WL. Bone marrow-derived cells contribute to vascular endothelial growth factor-induced angiogenesis in the adult mouse brain by supplying matrix metalloproteinase-9. Stroke. 2011 Feb; 42(2):453-8. PMID: 21164138; PMCID: PMC3026909.
      View in: PubMed, PubMed Central
    4. Gao P, Chen Y, Lawton MT, Barbaro NM, Yang GY, Su H, Ling F, Young WL. Evidence of endothelial progenitor cells in the human brain and spinal cord arteriovenous malformations. Neurosurgery. 2010 Oct; 67(4):1029-35. PMID: 20881566; PMCID: PMC2949301.
      View in: PubMed, PubMed Central
    5. Hao Q, Zhu Y, Su H, Shen F, Yang GY, Kim H, Young WL. VEGF Induces More Severe Cerebrovascular Dysplasia in Endoglin than in Alk1 Mice. Transl Stroke Res. 2010 Sep 01; 1(3):197-201. PMID: 20640035.
      View in: PubMed
    6. Delaloy C, Liu L, Lee JA, Su H, Shen F, Yang GY, Young WL, Ivey KN, Gao FB. MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors. Cell Stem Cell. 2010 Apr 02; 6(4):323-35. PMID: 20362537; PMCID: PMC2851637.
      View in: PubMed, PubMed Central
    7. Fan Y, Shen F, Frenzel T, Zhu W, Ye J, Liu J, Chen Y, Su H, Young WL, Yang GY. Endothelial progenitor cell transplantation improves long-term stroke outcome in mice. Ann Neurol. 2010 Apr; 67(4):488-97. PMID: 20437584.
      View in: PubMed
    8. Khachi S, Zhu Y, Yang GY. Preparation and analysis of endothelial progenitor cells associated with angiogenesis. Methods Mol Biol. 2010; 621:139-48. PMID: 20405364.
      View in: PubMed
    9. Su H, Kim H, Pawlikowska L, Kitamura H, Shen F, Cambier S, Markovics J, Lawton MT, Sidney S, Bollen AW, Kwok PY, Reichardt L, Young WL, Yang GY, Nishimura SL. Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis. Am J Pathol. 2010 Feb; 176(2):1018-27. PMID: 20019187; PMCID: PMC2808104.
      View in: PubMed, PubMed Central
    10. Gao P, Shen F, Gabriel RA, Law D, Yang EY, Yang E, Yang GY, Young WL, Su H. Attenuation of brain response to vascular endothelial growth factor-mediated angiogenesis and neurogenesis in aged mice. Stroke. 2009 Nov; 40(11):3596-600. PMID: 19745179; PMCID: PMC2783321.
      View in: PubMed, PubMed Central
    11. Chen Y, Hao Q, Kim H, Su H, Letarte M, Karumanchi SA, Lawton MT, Barbaro NM, Yang GY, Young WL. Soluble endoglin modulates aberrant cerebral vascular remodeling. Ann Neurol. 2009 Jul; 66(1):19-27. PMID: 19670444; PMCID: PMC2773229.
      View in: PubMed, PubMed Central
    12. Zhu W, Fan Y, Hao Q, Shen F, Hashimoto T, Yang GY, Gasmi M, Bartus RT, Young WL, Chen Y. Postischemic IGF-1 gene transfer promotes neurovascular regeneration after experimental stroke. J Cereb Blood Flow Metab. 2009 Sep; 29(9):1528-37. PMID: 19513085; PMCID: PMC2763573.
      View in: PubMed, PubMed Central
    13. Lee CZ, Xue Z, Hao Q, Yang GY, Young WL. Nitric oxide in vascular endothelial growth factor-induced focal angiogenesis and matrix metalloproteinase-9 activity in the mouse brain. Stroke. 2009 Aug; 40(8):2879-81. PMID: 19498186; PMCID: PMC2717176.
      View in: PubMed, PubMed Central
    14. Zhu Y, Cuevas IC, Gabriel RA, Su H, Nishimura S, Gao P, Fields A, Hao Q, Young WL, Yang GY, Boudreau NJ. Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain. J Neuropathol Exp Neurol. 2009 Jun; 68(6):626-32. PMID: 19458547; PMCID: PMC2728585.
      View in: PubMed, PubMed Central
    15. Gao P, Zhu Y, Ling F, Shen F, Lee B, Gabriel RA, Hao Q, Yang GY, Su H, Young WL. Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9. J Cereb Blood Flow Metab. 2009 Aug; 29(8):1482-90. PMID: 19471278; PMCID: PMC2745831.
      View in: PubMed, PubMed Central
    16. Kim H, Pawlikowska L, Chen Y, Su H, Yang GY, Young WL. Brain arteriovenous malformation biology relevant to hemorrhage and implication for therapeutic development. Stroke. 2009 Mar; 40(3 Suppl):S95-7. PMID: 19064791; PMCID: PMC2677752.
      View in: PubMed, PubMed Central
    17. Hao Q, Su H, Marchuk DA, Rola R, Wang Y, Liu W, Young WL, Yang GY. Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation. Am J Physiol Heart Circ Physiol. 2008 Dec; 295(6):H2250-6. PMID: 18835925; PMCID: PMC2614529.
      View in: PubMed, PubMed Central
    18. Hao Q, Liu J, Pappu R, Su H, Rola R, Gabriel RA, Lee CZ, Young WL, Yang GY. Contribution of bone marrow-derived cells associated with brain angiogenesis is primarily through leukocytes and macrophages. Arterioscler Thromb Vasc Biol. 2008 Dec; 28(12):2151-7. PMID: 18802012; PMCID: PMC2610019.
      View in: PubMed, PubMed Central
    19. Chen Y, Zhu W, Bollen AW, Lawton MT, Barbaro NM, Dowd CF, Hashimoto T, Yang GY, Young WL. Evidence of inflammatory cell involvement in brain arteriovenous malformations. Neurosurgery. 2008 Jun; 62(6):1340-9; discussion 1349-50. PMID: 18825001; PMCID: PMC2582017.
      View in: PubMed, PubMed Central
    20. Fan Y, Zhu W, Yang M, Zhu Y, Shen F, Hao Q, Young WL, Yang GY, Chen Y. Del-1 gene transfer induces cerebral angiogenesis in mice. Brain Res. 2008 Jul 11; 1219:1-7. PMID: 18534562; PMCID: PMC2553757.
      View in: PubMed, PubMed Central
    21. Fan Y, Shen F, Chen Y, Hao Q, Liu W, Su H, Young WL, Yang GY. Overexpression of netrin-1 induces neovascularization in the adult mouse brain. J Cereb Blood Flow Metab. 2008 Sep; 28(9):1543-51. PMID: 18461079; PMCID: PMC2581494.
      View in: PubMed, PubMed Central
    22. Zhu W, Fan Y, Frenzel T, Gasmi M, Bartus RT, Young WL, Yang GY, Chen Y. Insulin growth factor-1 gene transfer enhances neurovascular remodeling and improves long-term stroke outcome in mice. Stroke. 2008 Apr; 39(4):1254-61. PMID: 18309153; PMCID: PMC2553752.
      View in: PubMed, PubMed Central
    23. Gabriel RA, Yang GY. Gene therapy in cerebrovascular diseases. Curr Gene Ther. 2007 Dec; 7(6):421-33. PMID: 18045102.
      View in: PubMed
    24. Zhu W, Khachi S, Hao Q, Shen F, Young WL, Yang GY, Chen Y. Upregulation of EMMPRIN after permanent focal cerebral ischemia. Neurochem Int. 2008 May; 52(6):1086-91. PMID: 18164515; PMCID: PMC2375043.
      View in: PubMed, PubMed Central
    25. Zeng J, Liu J, Yang GY, Kelly MJ, James TL, Litt L. Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices. Anesthesiology. 2007 Oct; 107(4):630-40. PMID: 17893460.
      View in: PubMed
    26. Lee CZ, Xue Z, Zhu Y, Yang GY, Young WL. Matrix metalloproteinase-9 inhibition attenuates vascular endothelial growth factor-induced intracerebral hemorrhage. Stroke. 2007 Sep; 38(9):2563-8. PMID: 17673717.
      View in: PubMed
    27. Fan Y, Ye J, Shen F, Zhu Y, Yeghiazarians Y, Zhu W, Chen Y, Lawton MT, Young WL, Yang GY. Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro. J Cereb Blood Flow Metab. 2008 Jan; 28(1):90-8. PMID: 17519976; PMCID: PMC2581498.
      View in: PubMed, PubMed Central
    28. Fan Y, Yang GY. Therapeutic angiogenesis for brain ischemia: a brief review. J Neuroimmune Pharmacol. 2007 Sep; 2(3):284-9. PMID: 18040863.
      View in: PubMed
    29. Hao Q, Chen Y, Zhu Y, Fan Y, Palmer D, Su H, Young WL, Yang GY. Neutrophil depletion decreases VEGF-induced focal angiogenesis in the mature mouse brain. J Cereb Blood Flow Metab. 2007 Nov; 27(11):1853-60. PMID: 17392691.
      View in: PubMed
    30. Yao JS, Shen F, Young WL, Yang GY. Comparison of doxycycline and minocycline in the inhibition of VEGF-induced smooth muscle cell migration. Neurochem Int. 2007 Feb; 50(3):524-30. PMID: 17145119; PMCID: PMC1876824.
      View in: PubMed, PubMed Central
    31. Shen F, Su H, Liu W, Kan YW, Young WL, Yang GY. Recombinant adeno-associated viral vector encoding human VEGF165 induces neomicrovessel formation in the adult mouse brain. Front Biosci. 2006 Sep 01; 11:3190-8. PMID: 16720385.
      View in: PubMed
    32. Zhu Y, Lawton MT, Du R, Shwe Y, Chen Y, Shen F, Young WL, Yang GY. Expression of hypoxia-inducible factor-1 and vascular endothelial growth factor in response to venous hypertension. Neurosurgery. 2006 Sep; 59(3):687-96; discussion 687-96. PMID: 16955051.
      View in: PubMed
    33. Chen Y, Fan Y, Poon KY, Achrol AS, Lawton MT, Zhu Y, McCulloch CE, Hashimoto T, Lee C, Barbaro NM, Bollen AW, Yang GY, Young WL. MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations. Front Biosci. 2006 Sep 01; 11:3121-8. PMID: 16720380.
      View in: PubMed
    34. Shen F, Su H, Fan Y, Chen Y, Zhu Y, Liu W, Young WL, Yang GY. Adeno-associated viral-vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in mice. Stroke. 2006 Oct; 37(10):2601-6. PMID: 16946160.
      View in: PubMed
    35. Yao JS, Zhai W, Fan Y, Lawton MT, Barbaro NM, Young WL, Yang GY. Interleukin-6 upregulates expression of KDR and stimulates proliferation of human cerebrovascular smooth muscle cells. J Cereb Blood Flow Metab. 2007 Mar; 27(3):510-20. PMID: 16820800.
      View in: PubMed
    36. Zeng J, Yang GY, Ying W, Kelly M, Hirai K, James TL, Swanson RA, Litt L. Pyruvate improves recovery after PARP-1-associated energy failure induced by oxidative stress in neonatal rat cerebrocortical slices. J Cereb Blood Flow Metab. 2007 Feb; 27(2):304-15. PMID: 16736046.
      View in: PubMed
    37. Yao JS, Zhai W, Young WL, Yang GY. Interleukin-6 triggers human cerebral endothelial cells proliferation and migration: the role for KDR and MMP-9. Biochem Biophys Res Commun. 2006 Apr 21; 342(4):1396-404. PMID: 16516857.
      View in: PubMed
    38. Lee CZ, Yao JS, Huang Y, Zhai W, Liu W, Guglielmo BJ, Lin E, Yang GY, Young WL. Dose-response effect of tetracyclines on cerebral matrix metalloproteinase-9 after vascular endothelial growth factor hyperstimulation. J Cereb Blood Flow Metab. 2006 Sep; 26(9):1157-64. PMID: 16395286.
      View in: PubMed
    39. Chen Y, Pawlikowska L, Yao JS, Shen F, Zhai W, Achrol AS, Lawton MT, Kwok PY, Yang GY, Young WL. Interleukin-6 involvement in brain arteriovenous malformations. Ann Neurol. 2006 Jan; 59(1):72-80. PMID: 16278864.
      View in: PubMed
    40. Zhu Y, Lee C, Shen F, Du R, Young WL, Yang GY. Angiopoietin-2 facilitates vascular endothelial growth factor-induced angiogenesis in the mature mouse brain. Stroke. 2005 Jul; 36(7):1533-7. PMID: 15947259.
      View in: PubMed
    41. Hashimoto T, Wu Y, Lawton MT, Yang GY, Barbaro NM, Young WL. Coexpression of angiogenic factors in brain arteriovenous malformations. Neurosurgery. 2005 May; 56(5):1058-65; discussion 1058-65. PMID: 15854255.
      View in: PubMed
    42. Chen Y, Xu B, Arderiu G, Hashimoto T, Young WL, Boudreau N, Yang GY. Retroviral delivery of homeobox D3 gene induces cerebral angiogenesis in mice. J Cereb Blood Flow Metab. 2004 Nov; 24(11):1280-7. PMID: 15545924.
      View in: PubMed
    43. Young WL, Yang GY. Are there genetic influences on sporadic brain arteriovenous malformations? Stroke. 2004 Nov; 35(11 Suppl 1):2740-5. PMID: 15472089.
      View in: PubMed
    44. Zeng J, Hirai K, Yang GY, Ying W, Swanson RA, Kelly M, Mayer M, James TL, Litt L. Using 31P NMR spectroscopy at 14.1 Tesla to investigate PARP-1 associated energy failure and metabolic rescue in cerebrocortical slices. J Bioenerg Biomembr. 2004 Aug; 36(4):415-9. PMID: 15377881.
      View in: PubMed
    45. Yao JS, Chen Y, Zhai W, Xu K, Young WL, Yang GY. Minocycline exerts multiple inhibitory effects on vascular endothelial growth factor-induced smooth muscle cell migration: the role of ERK1/2, PI3K, and matrix metalloproteinases. Circ Res. 2004 Aug 20; 95(4):364-71. PMID: 15256478.
      View in: PubMed
    46. Lee CZ, Xu B, Hashimoto T, McCulloch CE, Yang GY, Young WL. Doxycycline suppresses cerebral matrix metalloproteinase-9 and angiogenesis induced by focal hyperstimulation of vascular endothelial growth factor in a mouse model. Stroke. 2004 Jul; 35(7):1715-9. PMID: 15166398.
      View in: PubMed
    47. Yang GY, Yao JS, Huey M, Hashimoto T, Young WL. Participation of PI3K and ERK1/2 pathways are required for human brain vascular smooth muscle cell migration. Neurochem Int. 2004 May; 44(6):441-6. PMID: 14687609.
      View in: PubMed
    48. Hirai K, Hayashi T, Chan PH, Zeng J, Yang GY, Basus VJ, James TL, Litt L. PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis. Brain Res Mol Brain Res. 2004 Apr 29; 124(1):51-61. PMID: 15093685.
      View in: PubMed
    49. Hashimoto T, Lawton MT, Wen G, Yang GY, Chaly T, Stewart CL, Dressman HK, Barbaro NM, Marchuk DA, Young WL. Gene microarray analysis of human brain arteriovenous malformations. Neurosurgery. 2004 Feb; 54(2):410-23; discussion 423-5. PMID: 14744289.
      View in: PubMed
    50. Hashimoto T, Wen G, Lawton MT, Boudreau NJ, Bollen AW, Yang GY, Barbaro NM, Higashida RT, Dowd CF, Halbach VV, Young WL. Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformations. Stroke. 2003 Apr; 34(4):925-31. PMID: 12649522.
      View in: PubMed
    51. Yang GY, Xu B, Hashimoto T, Huey M, Chaly T, Wen R, Young WL. Induction of focal angiogenesis through adenoviral vector mediated vascular endothelial cell growth factor gene transfer in the mature mouse brain. Angiogenesis. 2003; 6(2):151-8. PMID: 14739621.
      View in: PubMed
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