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Guohua Yuan, PhD

Photo of Guohua Yuan, PhD
Title(s)Postdoctoral Scholar, Neurological Surgery
SchoolSchool of Medicine
Address1651 4th Street, #001
San Francisco CA 94158
PronounsHe/Him/His
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    Collapse Biography 
    Collapse education and training
    Tsinghua University, Beijing, ChinaPh.D.01/2022Biology
    Xiamen University, Xiamen, ChinaMaster06/2016Physics
    Zhengzhou University, Zhengzhou, ChinaB. Eng.06/2013Materials Science and Engineering
    Collapse awards and honors
    Tsinghua University2016  - 2020The Future Scholar Fellowship
    Xiamen University2016  - 2016The Excellent Graduates Award
    Xiamen University2015  - 2015National Scholarship for Graduate Students
    Henan Province2011  - 2011First prize of the ninth Challenge Cup National College Students’ Extracurricular Science
    Tsinghua University2020  - 2020The Agilent Scholarship
    Tsinghua University2021  - 2021Comprehensive Prize for Graduate Students
    THU-IDG/McGovern Institute of Tsinghua University2022  - 2022Award for Outstanding Research Achievement

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Molecular dynamics of Brodmann Area 22 in development and autism. bioRxiv. 2026 Apr 03. Suresh V, Wigdor EM, Hao Y, Leonard R, Asfouri J, Griffiths M, Evans C, Yuan G, Rohani N, Weiss J, Dema C, Mukthar T, Lassen FH, Schafer N, Dong S, Palmer DS, Chang EF, Sanders SJ, Nowakowski TJ. PMID: 41959023; PMCID: PMC13060142.
      View in: PubMed   Mentions:
    2. Gallium-doped mesoporous bioactive glass nanoparticles for antibacterial and immunomodulatory effects in vital pulp therapy. Acta Biomater. 2026 May; 215:228-244. Pi Y, Liang Z, Liu X, Xu X, Chen Z, Yang G, Guo L, Yuan G. PMID: 41871676.
      View in: PubMed   Mentions:
    3. Calcium phosphate polymer induced liquid precursor improves dentin bonding performance of primary teeth with dentinogenesis imperfecta type II. BMC Oral Health. 2026 Mar 06; 26(1). Wang A, Liu X, Wang Y, Li X, Yang J, Tang R, Chen Z, Yang G, Chen X, Chen Z, Yuan G. PMID: 41792681; PMCID: PMC13081329.
      View in: PubMed   Mentions:
    4. Minimizing far-extending chromatin perturbation in genome editing preserves stem cell identity. Cell Stem Cell. 2026 Mar 05; 33(3):470-486.e14. Zhu M, Yuan J, Meng Q, Yu J, Xu X, Xu M, Ren X, Hu Y, Wei G, Jia Z, Yuan G, Zang L, Liu S, Yang Y, Zheng Y, Wang J, Cong T, Xie W, Lan X, Cong L, Ma T, Ding S, Guo W, Zhang X, Li Y. PMID: 41742419.
      View in: PubMed   Mentions:
    5. Dose-dependent NFI regulation of progenitor lifespan and output underlying human neocortical malformation. bioRxiv. 2025 Dec 27. Zhang Q, Yuan G, Albizzati E, Yang J, Zhao Z, Yu X, Chang X, Lee CH, Du H, Lao Z, Krishnamurthy A, Zhang X, Lv X, Tang X, Hu S, Chi Y, Ma J, Gronostajski RM, Richards LJ, Zhang J, Joyner AL, Tchieu J, Li Y, Shi SH. PMID: 41509446; PMCID: PMC12776466.
      View in: PubMed   Mentions:
    6. Xeligekimab, an Interleukin-17A Antagonist for Active Radiographic Axial Spondyloarthritis in Chinese Patients: 16- and 48-Week Results from a Phase III, Randomized, Double-Blind, Placebo-Controlled Study. BioDrugs. 2026 Jan; 40(1):151-162. Zhang S, Xu D, Liu S, Li S, Wang X, Yuan F, Gou W, Xu B, Sun L, Gu J, Zhou D, Li X, Kong N, Zhao Y, Hao J, Li T, Fan X, Shu Q, Wei H, Jiang T, Yang J, Qian L, Sun H, Cai X, Jiang Z, Yuan G, Qin L, Yang M, Xu J, Fan W, Sun L, Zhang H, Zhang C, Zhang N, Da Z, Hu J, Jin J, Liu J, Dai L, Dong L, Wang W, Zeng X. PMID: 41247398; PMCID: PMC12790509.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    7. Disruption of Cell-Type-Specific Molecular Programs of Medium Spiny Neurons in Autism. bioRxiv. 2025 Nov 07. Yuan G, Suresh V, Wigdor E, Hao Y, Leonard R, Steyert M, Griffiths M, Evans C, Rohani N, Weiss J, Lassen FH, Schafer N, Dong S, Palmer DS, Sanders SJ, Nowakowski TJ. PMID: 41279076; PMCID: PMC12637482.
      View in: PubMed   Mentions:
    8. The new frontier in understanding human and mammalian brain development. Nature. 2025 Nov; 647(8088):51-59. Nowakowski TJ, Nano PR, Matho KS, Chen X, Corrigan EK, Ding W, Gao Y, Heffel M, Jayakumar J, Kaplan HS, Kronman FN, Kovner R, Mannens CCA, Song M, Steyert MR, Venkatesan S, Wallace JL, Wang L, Werner JM, Zhang D, Yuan G, Zuo G, Ament SA, Colantuoni C, Dulac C, Fan R, Gillis J, Kriegstein AR, Krienen FM, Kim Y, Linnarsson S, Mitra PP, Pollen AA, Sestan N, Tward DJ, van Velthoven CTJ, Yao Z, Bhaduri A, Zeng H. PMID: 41193845.
      View in: PubMed   Mentions:
    9. Expert consensus on the treatment of oral diseases in pregnant women and infants. Int J Oral Sci. 2025 Aug 29; 17(1):62. Zhang J, Zhou C, Zheng L, Wang J, Xia B, Zhao W, Wei X, Huang Z, Chen X, Ge S, Yan F, Zhou J, Xuan K, Wu LA, Cao Z, Yuan G, Zhao J, Chen Z, Zhang L, You Y, Zou J, Guo W. PMID: 40883270; PMCID: PMC12397245.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. H3K36me3 modification by SETD2 is essential for Col11a2 and Sema3e transcription to maintain dentinogenesis in mice. Development. 2025 Jul 15; 152(14). Niu J, Fu J, Feng H, Han J, Chen Z, Yang G, Yuan G. PMID: 40554768; PMCID: PMC12338916.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. Integrating reproductive states and social cues in the control of sociosexual behaviors. Cell. 2025 Jun 26; 188(13):3530-3549.e24. Wang Y, Song X, Chen X, Zhou Y, Ma J, Zhang F, Wei L, Qi G, Yadav N, Miao B, Yan Y, Yuan G, Mi D, Rajasethupathy P, Ibañez-Tallon I, Jia X, Heintz N, Li K. PMID: 40398420.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. The Mdm2-p53 axis links cementocyte survival to cellular cementum volume. J Bone Miner Res. 2025 Apr 21; 40(4):548-560. Tian X, Yang G, Zheng H, Pi Y, Cao Z, Duan P, Chen Z, Yuan G. PMID: 39903703.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    13. Dentin sialoprotein promotes endothelial differentiation of dental pulp stem cells through DSPaa34-50-endoglin-AKT1 axis. J Biol Chem. 2025 04; 301(4):108380. Xu X, Fu J, Yang G, Chen Z, Chen S, Yuan G. PMID: 40049415; PMCID: PMC11997338.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    14. Axin1 regulates tooth root development by inhibiting AKT1-mTORC1 activation and Shh translation in Hertwig's epithelial root sheath. Development. 2024 Nov 01; 151(21). Zheng X, Huang H, Zhou Z, Guo W, Yang G, Chen Z, Chen D, Chen Y, Yuan G. PMID: 39344774.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. CREB3L1 deficiency impairs odontoblastic differentiation and molar dentin deposition partially through the TMEM30B. Int J Oral Sci. 2024 10 10; 16(1):59. Li Y, Lin Y, Guo J, Huang D, Zuo H, Zhang H, Yuan G, Liu H, Chen Z. PMID: 39384739; PMCID: PMC11464721.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    16. Sustained store-operated calcium entry utilizing activated chromatin state leads to instability in iTregs. Elife. 2023 12 06; 12. Lyu H, Yuan G, Liu X, Wang X, Geng S, Xia T, Zhou X, Li Y, Hu X, Shi Y. PMID: 38055613; PMCID: PMC10699804.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    17. CHIP inhibits odontoblast differentiation through promoting DLX3 polyubiquitylation and degradation. Development. 2023 05 15; 150(10). Zheng H, Zhang X, Fu J, Xue Y, Chen Z, Yang G, Chen Y, Chen D, Yuan G. PMID: 37213079.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    18. Klf4 haploinsufficiency in Sp7+ lineage leads to underdeveloped mandibles and insufficient elongation of mandibular incisor. Biochim Biophys Acta Mol Basis Dis. 2023 03; 1869(3):166636. Guo J, Yu S, Zhang H, Zhang L, Yuan G, Liu H, Chen Z. PMID: 36584722.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    19. Expert consensus on clinical management for early childhood caries. Hua Xi Kou Qiang Yi Xue Za Zhi. 2022 Oct 01; 40(5):495-503. Zhang Q, Wang J, Xia B, Zhao W, Chen X, Jiang B, Huang Y, Wu L, Yuan G, Zou J. PMID: 38596969; PMCID: PMC9588867.
      View in: PubMed   Mentions: 2     Fields:    
    20. Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis. Front Physiol. 2022; 13:923185. Tian C, Chai J, Liu W, Zhang X, Li Y, Zuo H, Yuan G, Zhang H, Liu H, Chen Z. PMID: 35784864; PMCID: PMC9240783.
      View in: PubMed   Mentions: 5  
    21. Hidden Intermediate State and Second Pathway Determining Folding and Unfolding Dynamics of GB1 Protein at Low Forces. Phys Rev Lett. 2020 Nov 06; 125(19):198101. Guo Z, Hong H, Yuan G, Qian H, Li B, Cao Y, Wang W, Wu CX, Chen H. PMID: 33216575.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    22. Biomineral Precursor Formation Is Initiated by Transporting Calcium and Phosphorus Clusters from the Endoplasmic Reticulum to Mitochondria. Adv Sci (Weinh). 2020 Apr; 7(8):1902536. Tang C, Wei Y, Gu L, Zhang Q, Li M, Yuan G, He Y, Huang L, Liu Y, Zhang Y. PMID: 32328413; PMCID: PMC7175271.
      View in: PubMed   Mentions: 24     Fields:    
    23. Improved data analysis method of single-molecule experiments based on probability optimization. Chinese Physics B. 2018; 27(1):018703. Weili Zhai, Guohua Yuan, Chao Liu, Hu Chen.
    24. Elasticity of the Transition State Leading to an Unexpected Mechanical Stabilization of Titin Immunoglobulin Domains. Angew Chem Int Ed Engl. 2017 05 08; 56(20):5490-5493. Yuan G, Le S, Yao M, Qian H, Zhou X, Yan J, Chen H. PMID: 28394039.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    25. Dentin Sialoprotein is a Novel Substrate of Matrix Metalloproteinase 9 in vitro and in vivo. Sci Rep. 2017 02 14; 7:42449. Yuan G, Chen L, Feng J, Yang G, Ni Q, Xu X, Wan C, Lindsey M, Donly KJ, MacDougall M, Chen Z, Chen S. PMID: 28195206; PMCID: PMC5307955.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    26. The Dentin Sialoprotein (DSP) Domain Regulates Dental Mesenchymal Cell Differentiation through a Novel Surface Receptor. Sci Rep. 2016 07 19; 6:29666. Wan C, Yuan G, Luo D, Zhang L, Lin H, Liu H, Chen L, Yang G, Chen S, Chen Z. PMID: 27430624; PMCID: PMC4949421.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    27. The kinetics of forcedependent hybridization and strand-peeling of short DNA fragments. Science China Physics, Mechanics & Astronomy. 2016; 59(8):680013. Zhoujie Yang, Guohua Yuan, Weili Zhai, Jie Yan, Hu Chen.
    28. FGF8 signaling sustains progenitor status and multipotency of cranial neural crest-derived mesenchymal cells in vivo and in vitro. J Mol Cell Biol. 2015 Oct; 7(5):441-54. Shao M, Liu C, Song Y, Ye W, He W, Yuan G, Gu S, Lin C, Ma L, Zhang Y, Tian W, Hu T, Chen Y. PMID: 26243590; PMCID: PMC4589951.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    29. Dynamics of equilibrium folding and unfolding transitions of titin immunoglobulin domain under constant force. J Am Chem Soc. 2015; 137(10):3540-6. Hu Chen, Guohua Yuan (co-first author), Ricksen S. Winardhi, Mingxi Yao, Ionel Popa, Julio M. Fernandez, and Jie Yan.
    30. The non-canonical BMP and Wnt/β-catenin signaling pathways orchestrate early tooth development. Development. 2015 Jan 01; 142(1):128-39. Yuan G, Yang G, Zheng Y, Zhu X, Chen Z, Zhang Z, Chen Y. PMID: 25428587; PMCID: PMC4299140.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    31. An atypical canonical bone morphogenetic protein (BMP) signaling pathway regulates Msh homeobox 1 (Msx1) expression during odontogenesis. J Biol Chem. 2014 Nov 07; 289(45):31492-502. Yang G, Yuan G, Ye W, Cho KW, Chen Y. PMID: 25274628; PMCID: PMC4223347.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    32. Complementary analysis of microRNA and mRNA expression during phorbol 12-myristate 13-acetate (TPA)-induced differentiation of HL-60 cells. Biotechnol Lett. 2008 Dec; 30(12):2045-52. Chen A, Luo M, Yuan G, Yu J, Deng T, Zhang L, Zhou Y, Mitchelson K, Cheng J. PMID: 18648749.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
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