Guohua Yuan, PhD

Photo of Guohua Yuan, PhD
Title(s)Postdoctoral Scholar, Neurological Surgery
SchoolSchool of Medicine
Address1651 4th Street, #511C
San Francisco CA 94158
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    Collapse Biography 
    Collapse education and training
    Tsinghua University, Beijing, ChinaPh.D.01/2022Biology
    Xiamen University, Xiamen, ChinaMaster06/2016Physics
    Zhengzhou University, Zhengzhou, ChinaB. Eng.06/2013Materials Science and Engineering
    Collapse awards and honors
    Tsinghua University2016  - 2020The Future Scholar Fellowship
    Xiamen University2016  - 2016The Excellent Graduates Award
    Xiamen University2015  - 2015National Scholarship for Graduate Students
    Henan Province2011  - 2011First prize of the ninth Challenge Cup National College Students’ Extracurricular Science
    Tsinghua University2020  - 2020The Agilent Scholarship
    Tsinghua University2021  - 2021Comprehensive Prize for Graduate Students
    THU-IDG/McGovern Institute of Tsinghua University2022  - 2022Award for Outstanding Research Achievement

    Collapse Bibliographic 
    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2-KLF4. Cell Prolif. 2026 Aug 06; e70269. Zeng W, Lin Y, Gao Y, Huang D, Li Y, Ruan H, Yuan G, Liu H, Chen Z. PMID: 42560112; PMCID: PMC13446069.
      View in: PubMed   Mentions:    Fields:    
    2. Apoptosis of Mdm2-deficient osteocytes enhances osteogenesis through TRPM8-enriched apoptotic vesicles. Bone Res. 2026 Aug 03; 14(1). Liu X, Zheng H, Wang A, Liu J, Chen Z, Chen Y, Yang G, Chen D, Zhang Y, Yuan G. PMID: 42543262; PMCID: PMC13429674.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Improvement of the biological performance of filling materials for primary teeth after pulpectomy by incorporating Ca-polyP microparticles. Dent Mater. 2026 Jul 01. Ouyang Y, Wang J, Ma J, Yu J, Zhou H, Yang L, Yuan G. PMID: 42386450.
      View in: PubMed   Mentions:    Fields:    
    4. Evaluation of the Safety, Tolerability, Pharmacokinetics, and Efficacy of Subcutaneous Firsekibart in Gout: A Phase Ib/II Clinical Trial. Int J Rheum Dis. 2026 Jul; 29(7):e70785. Xue Y, Zhang N, Hu J, Gou W, Chen L, Tang L, Li Y, Ma L, Zhang Z, Li M, Dong L, Duan X, Qin L, Yuan G, Miao L, Wu J, Qian L, Hu W, Tan W, Li J, Da Z, Xu Q, Chen C, Luo T, Zhang J, Zou H. PMID: 42498684; PMCID: PMC13400318.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    5. Lineage tracing in human cortical development. Curr Opin Genet Dev. 2026 Jun 25; 100:102506. Yuan G, Steyert M, Nowakowski TJ. PMID: 42349067.
      View in: PubMed   Mentions:    Fields:    
    6. Molecular dynamics of Brodmann Area 22 in development and autism. bioRxiv. 2026 Apr 03. Suresh V, Wigdor EM, Hao Y, Leonard R, Asfouri J, Griffiths M, Evans C, Yuan G, Rohani N, Weiss J, Dema C, Mukthar T, Lassen FH, Schafer N, Dong S, Palmer DS, Chang EF, Sanders SJ, Nowakowski TJ. PMID: 41959023; PMCID: PMC13060142.
      View in: PubMed   Mentions:
    7. Minimizing far-extending chromatin perturbation in genome editing preserves stem cell identity. Cell Stem Cell. 2026 Mar 05; 33(3):470-486.e14. Zhu M, Yuan J, Meng Q, Yu J, Xu X, Xu M, Ren X, Hu Y, Wei G, Jia Z, Yuan G, Zang L, Liu S, Yang Y, Zheng Y, Wang J, Cong T, Xie W, Lan X, Cong L, Ma T, Ding S, Guo W, Zhang X, Li Y. PMID: 41742419.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. Dose-dependent NFI regulation of progenitor lifespan and output underlying human neocortical malformation. bioRxiv. 2025 Dec 27. Zhang Q, Yuan G, Albizzati E, Yang J, Zhao Z, Yu X, Chang X, Lee CH, Du H, Lao Z, Krishnamurthy A, Zhang X, Lv X, Tang X, Hu S, Chi Y, Ma J, Gronostajski RM, Richards LJ, Zhang J, Joyner AL, Tchieu J, Li Y, Shi SH. PMID: 41509446; PMCID: PMC12776466.
      View in: PubMed   Mentions:
    9. Disruption of Cell-Type-Specific Molecular Programs of Medium Spiny Neurons in Autism. bioRxiv. 2025 Nov 07. Yuan G, Suresh V, Wigdor E, Hao Y, Leonard R, Steyert M, Griffiths M, Evans C, Rohani N, Weiss J, Lassen FH, Schafer N, Dong S, Palmer DS, Sanders SJ, Nowakowski TJ. PMID: 41279076; PMCID: PMC12637482.
      View in: PubMed   Mentions:
    10. The new frontier in understanding human and mammalian brain development. Nature. 2025 11; 647(8088):51-59. Nowakowski TJ, Nano PR, Matho KS, Chen X, Corrigan EK, Ding W, Gao Y, Heffel M, Jayakumar J, Kaplan HS, Kronman FN, Kovner R, Mannens CCA, Song M, Steyert MR, Venkatesan S, Wallace JL, Wang L, Werner JM, Zhang D, Yuan G, Zuo G, Ament SA, Colantuoni C, Dulac C, Fan R, Gillis J, Kriegstein AR, Krienen FM, Kim Y, Linnarsson S, Mitra PP, Pollen AA, Sestan N, Tward DJ, van Velthoven CTJ, Yao Z, Bhaduri A, Zeng H. PMID: 41193845; PMCID: PMC13108688.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    11. Integrating reproductive states and social cues in the control of sociosexual behaviors. Cell. 2025 Jun 26; 188(13):3530-3549.e24. Wang Y, Song X, Chen X, Zhou Y, Ma J, Zhang F, Wei L, Qi G, Yadav N, Miao B, Yan Y, Yuan G, Mi D, Rajasethupathy P, Ibañez-Tallon I, Jia X, Heintz N, Li K. PMID: 40398420.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    12. A Novel Variant in Dentin Sialophosphoprotein (DSPP) Gene Causes Dentinogenesis Imperfecta Type III: Case Report. Mol Genet Genomic Med. 2025 Mar; 13(3):e70087. Wang Y, Xu X, Ding Y, Yuan G. PMID: 40040554; PMCID: PMC11880773.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Unveiling the roles of LEMD proteins in cellular processes. Life Sci. 2024 Nov 15; 357:123116. Wang Y, Chen Z, Yang G, Yuan G. PMID: 39374771.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    14. Image fusion-based low-dose CBCT enhancement method for visualizing miniscrew insertion in the infrazygomatic crest. BMC Med Imaging. 2024 05 17; 24(1):114. Sun P, Yang J, Tian X, Yuan G. PMID: 38760689; PMCID: PMC11100247.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Application of Oxygen Saturation Test after Replantation of Avulsed Immature Permanent Teeth: A Prospective Observational Study. J Endod. 2024 Jul; 50(7):954-961. Yang J, Liu Z, Chen Z, Yang G, Yuan G. PMID: 38604473.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. piR-368 promotes odontoblastic differentiation of dental papilla cells via the Smad1/5 signaling pathway by targeting Smurf1. Connect Tissue Res. 2024 01; 65(1):53-62. Xing X, She Y, Yuan G, Yang G. PMID: 37978579.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    17. Sustained store-operated calcium entry utilizing activated chromatin state leads to instability in iTregs. Elife. 2023 12 06; 12. Lyu H, Yuan G, Liu X, Wang X, Geng S, Xia T, Zhou X, Li Y, Hu X, Shi Y. PMID: 38055613; PMCID: PMC10699804.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    18. AAV6-Mediated Gene Therapy Prevents Developmental Dentin Defects in a Dentinogenesis Imperfecta Type Ⅲ Mouse Model. Hum Gene Ther. 2023 06; 34(11-12):567-577. Fu J, Zheng H, Ou Y, Yang G, Chen Z, Yuan G. PMID: 37014084.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    19. Phosphorylation of ATF2 promotes odontoblastic differentiation via intrinsic HAT activity. J Genet Genomics. 2023 07; 50(7):497-510. Zuo H, Xiao Y, Han J, Lin Y, Tian C, Zhang S, Yuan G, Liu H, Chen Z. PMID: 36809837.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    20. A WWP2-PTEN-KLF5 signaling axis regulates odontoblast differentiation and dentinogenesis in mice. J Biol Chem. 2022 08; 298(8):102220. Fu J, Zhang X, Zheng H, Yang G, Chen Z, Yuan G. PMID: 35780838; PMCID: PMC9358474.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    21. The regulation of Msx1 by BMP4/pSmad1/5 signaling is mediated by importin7 in dental mesenchymal cells. Cells Dev. 2022 03; 169:203763. She Y, Zhang Y, Xiao Z, Yuan G, Yang G. PMID: 34995814.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    22. Sustained calcium ion release from bioceramics promotes CaSR-mediated M2 macrophage polarization for osteoinduction. J Leukoc Biol. 2021 09; 110(3):485-496. Zhang J, Wu Q, Yin C, Jia X, Zhao Z, Zhang X, Yuan G, Hu H, Zhao Q. PMID: 34184323.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    23. Hidden Intermediate State and Second Pathway Determining Folding and Unfolding Dynamics of GB1 Protein at Low Forces. Phys Rev Lett. 2020 Nov 06; 125(19):198101. Guo Z, Hong H, Yuan G, Qian H, Li B, Cao Y, Wang W, Wu CX, Chen H. PMID: 33216575.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    24. Ginkgolide B attenuates collagen-induced rheumatoid arthritis and regulates fibroblast-like synoviocytes-mediated apoptosis and inflammation. Ann Transl Med. 2020 Nov; 8(22):1497. Xie C, Jiang J, Liu J, Yuan G, Zhao Z. PMID: 33313242; PMCID: PMC7729381.
      View in: PubMed   Mentions: 14  
    25. Gelatinases Cleave Dentin Sialoprotein Intracellularly. Front Physiol. 2020; 11:686. Gou X, Xue Y, Zheng H, Yang G, Chen S, Chen Z, Yuan G. PMID: 32670089; PMCID: PMC7330055.
      View in: PubMed   Mentions: 4  
    26. Triptolide suppresses human synoviocyte MH7A cells mobility and maintains redox balance by inhibiting autophagy. Biomed Pharmacother. 2019 Jul; 115:108911. Xie C, Jiang J, Liu J, Yuan G, Zhao Z. PMID: 31079001.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    27. Quaking promotes the odontoblastic differentiation of human dental pulp stem cells. J Cell Physiol. 2018 09; 233(9):7292-7304. Li S, Lin C, Zhang J, Tao H, Liu H, Yuan G, Chen Z. PMID: 29663385.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    28. Improved data analysis method of single-molecule experiments based on probability optimization. Chinese Physics B. 2018; 27(1):018703. Weili Zhai, Guohua Yuan, Chao Liu, Hu Chen.
    29. Comparative evaluation of the shaping ability of single-file system versus multi-file system in severely curved root canals. J Dent Sci. 2018 Mar; 13(1):37-42. Yuan G, Yang G. PMID: 30895092; PMCID: PMC6388865.
      View in: PubMed   Mentions: 7  
    30. Elasticity of the Transition State Leading to an Unexpected Mechanical Stabilization of Titin Immunoglobulin Domains. Angew Chem Int Ed Engl. 2017 05 08; 56(20):5490-5493. Yuan G, Le S, Yao M, Qian H, Zhou X, Yan J, Chen H. PMID: 28394039.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    31. Sp1 is a competitive endogenous RNA of Klf4 during odontoblast differentiation. Int J Biochem Cell Biol. 2017 04; 85:159-165. Zhang J, Liu H, Lin H, Li S, Tao H, Zhang L, Yuan G, Chen Z. PMID: 28238937.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    32. The kinetics of forcedependent hybridization and strand-peeling of short DNA fragments. Science China Physics, Mechanics & Astronomy. 2016; 59(8):680013. Zhoujie Yang, Guohua Yuan, Weili Zhai, Jie Yan, Hu Chen.
    33. SP1 promotes the odontoblastic differentiation of dental papilla cells. Dev Growth Differ. 2015 Jun; 57(5):400-407. Zhang J, Lin H, Liu H, Zhang L, Yuan G, Chen Z. PMID: 26010576.
      View in: PubMed   Mentions: 3     Fields:    
    34. Dynamics of equilibrium folding and unfolding transitions of titin immunoglobulin domain under constant force. J Am Chem Soc. 2015; 137(10):3540-6. Hu Chen, Guohua Yuan (co-first author), Ricksen S. Winardhi, Mingxi Yao, Ionel Popa, Julio M. Fernandez, and Jie Yan.
    35. MMP9 deficiency increased the size of experimentally induced apical periodontitis. J Endod. 2014 May; 40(5):658-64. Wan C, Yuan G, Yang J, Sun Q, Zhang L, Zhang J, Zhang L, Chen Z. PMID: 24767560.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    36. Domain of dentine sialoprotein mediates proliferation and differentiation of human periodontal ligament stem cells. PLoS One. 2013; 8(12):e81655. Ozer A, Yuan G, Yang G, Wang F, Li W, Yang Y, Guo F, Gao Q, Shoff L, Chen Z, Gay IC, Donly KJ, MacDougall M, Chen S. PMID: 24400037; PMCID: PMC3882282.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    37. Adenosine monophosphate-activated protein kinase/mammalian target of rapamycin-dependent autophagy protects human dental pulp cells against hypoxia. J Endod. 2013 Jun; 39(6):768-73. Zhou Q, Liu H, Sun Q, Zhang L, Lin H, Yuan G, Zhang L, Chen Z. PMID: 23683277.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    38. miR-145 and miR-143 regulate odontoblast differentiation through targeting Klf4 and Osx genes in a feedback loop. J Biol Chem. 2013 Mar 29; 288(13):9261-71. Liu H, Lin H, Zhang L, Sun Q, Yuan G, Zhang L, Chen S, Chen Z. PMID: 23430263; PMCID: PMC3610997.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    39. MicroRNA-338-3p promotes differentiation of mDPC6T into odontoblast-like cells by targeting Runx2. Mol Cell Biochem. 2013 May; 377(1-2):143-9. Sun Q, Liu H, Lin H, Yuan G, Zhang L, Chen Z. PMID: 23380982.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    40. KLF4 promotes the odontoblastic differentiation of human dental pulp cells. J Endod. 2011 Jul; 37(7):948-54. Lin H, Xu L, Liu H, Sun Q, Chen Z, Yuan G, Chen Z. PMID: 21689550.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    41. Immunohistochemical localization of LIM mineralization protein 1 during mouse molar development. J Mol Histol. 2010 Oct; 41(4-5):199-203. Fang P, Wang X, Zhang L, Yuan G, Chen Z, Zhang Q. PMID: 20706776.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
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