Guoxun Zhang • UCSF Profiles

Guoxun Zhang, PhD

Title(s)	Postdoctoral Scholar, Pharmaceutical Chemistry
School	School of Pharmacy
Address	1700 4th Street, #301D San Francisco CA 94158
Pronouns	He/Him/His
vCard	Download vCard

Biography

education and training

Department of Automation, Tsinghua University, Beijing, China	PhD	2024	AI ehnaced microscopy
Department of Engineering Physics, Tsinghua University, Beijing, China	Bachelor	2019	MRI
Department of Materials Science and Engineering, Tsinghua University, Beijing, China		2016

Overview

keywords

AI enhanced microscopy, Foundation AI models for medicine, Robotic high-throughput imaging

Mentoring

ORNG Applications

Featured Publications

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

A Generative Lung CT Foundation Model Facilitating Disease Diagnosis and Medical Imaging. medRxiv. 2025. Zebin Gao†, Guoxun Zhang†, Hengrui Liang†, Jiaxin Liu, Liangdi Ma, Tianyun Wang, YuJia Chen, Yuchen Guo‡, Jianxing He‡, Feng Xu‡ & Qionghai Dai‡.
Self-supervised denoising for medical imaging enhancement. BMEMat. 2025. Guoxun Zhang, Yuanyuan Wei, Ho-Pui Ho.
Dark-based optical sectioning assists background removal in fluorescence microscopy. Nat Methods. 2025 Jun; 22(6):1299-1310. Cao R, Li Y, Zhou Y, Li M, Lin F, Wang W, Zhang G, Wang G, Jin B, Ren W, Sun Y, Zhao Z, Zhang W, Sun J, Hou Y, Xu X, Hu J, Shi W, Fu S, Liang Q, Lu Y, Li C, Zhao Y, Li Y, Kuang D, Wu J, Fei P, Qu J, Xi P. PMID: 40355726.

View in: PubMed Mentions: Fields:
Cli Clinical Laboratory Techniques
Accurate and Generalist Nuclei Acid Quantification Leveraging the Zero‐Shot Segment Anything Model. Advanced science. 2024. Yuanyuan Wei, Shanhang Luo, Changran Xu, Yingqi Fu, Yi Zhang, Fuyang Qu, Guoxun Zhang, Yi-Ping Ho, Ho-Pui Ho‡, Wu Yuan.
SAM-dPCR: Accurate and Generalist Nuclei Acid Quantification Leveraging the Zero-Shot Segment Anything Model. Adv Sci (Weinh). 2025 Feb; 12(7):e2406797. Wei Y, Luo S, Xu C, Fu Y, Zhang Y, Qu F, Zhang G, Ho YP, Ho HP, Yuan W. PMID: 39731324; PMCID: PMC11831435.

View in: PubMed Mentions: 1 Fields:
Bio Biomedical Engineering
Translation:Humans
High-speed in toto 3D imaging with isotropic resolution by scanning light-field tomography. Optica. 2024. Yifan Chen†, Jiamin Wu†, Bo Xiong, Zhi Lu, Yuduo Guo, Yi Zhang, Jiaqi Fan, Guihua Xiao, Guoxun Zhang, Xiaopeng Li, Xukang Wang, Zhifeng Zhao, and Qionghai Dai.
Multifocal fluorescence video-rate imaging of centimetre-wide arbitrarily shaped brain surfaces at micrometric resolution. Nat Biomed Eng. 2024 Jun; 8(6):740-753. Xie H, Han X, Xiao G, Xu H, Zhang Y, Zhang G, Li Q, He J, Zhu D, Yu X, Dai Q. PMID: 38057428; PMCID: PMC11250366.

View in: PubMed Mentions: 4 Fields:
Bio Biomedical Engineering
Translation:Animals Cells
Bio-friendly long-term subcellular dynamic recording by self-supervised image enhancement microscopy. Nat Methods. 2023 Dec; 20(12):1957-1970. Zhang G, Li X, Zhang Y, Han X, Li X, Yu J, Liu B, Wu J, Yu L, Dai Q. PMID: 37957429; PMCID: PMC10703694.

View in: PubMed Mentions: 4 Fields:
Cli Clinical Laboratory Techniques
Translation:Animals
Rapid detection of neurons in widefield calcium imaging datasets after training with synthetic data. Nat Methods. 2023 May; 20(5):747-754. Zhang Y, Zhang G, Han X, Wu J, Li Z, Li X, Xiao G, Xie H, Fang L, Dai Q. PMID: 37002377; PMCID: PMC10172132.

View in: PubMed Mentions: 17 Fields:
Cli Clinical Laboratory Techniques
Translation:Animals Cells
Real-time denoising enables high-sensitivity fluorescence time-lapse imaging beyond the shot-noise limit. Nat Biotechnol. 2023 Feb; 41(2):282-292. Li X, Li Y, Zhou Y, Wu J, Zhao Z, Fan J, Deng F, Wu Z, Xiao G, He J, Zhang Y, Zhang G, Hu X, Chen X, Zhang Y, Qiao H, Xie H, Li Y, Wang H, Fang L, Dai Q. PMID: 36163547; PMCID: PMC9931589.

View in: PubMed Mentions: 35 Fields:
Bio Biotechnology
Translation:Animals
Reinforcing neuron extraction and spike inference in calcium imaging using deep self-supervised denoising. Nat Methods. 2021 Nov; 18(11):1395-1400. Li X, Zhang G, Wu J, Zhang Y, Zhao Z, Lin X, Qiao H, Xie H, Wang H, Fang L, Dai Q. PMID: 34400836.

View in: PubMed Mentions: 50 Fields:
Cli Clinical Laboratory Techniques
Translation:Animals Cells
Iterative tomography with digital adaptive optics permits hour-long intravital observation of 3D subcellular dynamics at millisecond scale. Cell. 2021 Jun 10; 184(12):3318-3332.e17. Wu J, Lu Z, Jiang D, Guo Y, Qiao H, Zhang Y, Zhu T, Cai Y, Zhang X, Zhanghao K, Xie H, Yan T, Zhang G, Li X, Jiang Z, Lin X, Fang L, Zhou B, Xi P, Fan J, Yu L, Dai Q. PMID: 34038702.

View in: PubMed Mentions: 57 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Unsupervised content-preserving transformation for optical microscopy. Light Sci Appl. 2021 Mar 01; 10(1):44. Li X, Zhang G, Qiao H, Bao F, Deng Y, Wu J, He Y, Yun J, Lin X, Xie H, Wang H, Dai Q. PMID: 33649308; PMCID: PMC7921581.

View in: PubMed Mentions: 31