Christian Von Buedingen, MD

TitleAssoc Professor in Residence
SchoolUCSF School of Medicine
Address675 Nelson Rising Lane
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    Goethe University, Frankfurt, GermanyM.D.1996School of Medicine
    Klinikum Grosshadern, L. Maximilians University, Munich, GermanyInternship1997Neurology
    University of California, San FranciscoPostdoctoral Studies2003Graduate Division/Neurology
    University Hospital of Zürich, SwitzerlandResidency2007Neurology
    Zürcher Höhenklinik Wald, SwitzerlandResidency2008Internal Medicine
    University of Zürich, SwitzerlandVenia legendi (Privatdozent, PhD Equivalent)2008School of Medicine
    Collapse Awards and Honors
    University of Goettingen, Germany2005Helmut Bauer-Award for Multiple Sclerosis Research
    UCSF2009Debbie and Andy Rachleff Professor in Neurology

    Collapse Overview 
    Collapse Overview
    Dr. H.-Christian von Büdingen earned his medical degree from the Johann-Wolfgang Goethe-University in Frankfurt/Main, Germany. He received his clinical training as a neurologist in Munich, Germany (1996-1997) and Zürich, Switzerland (2003-2008). From 1998-2003 he was a postdoctoral fellow in Dr. Hauser's and Dr. Genain's neuroimmunology laboratory at UCSF. He became a lecturer in Neurology at the University of Zürich, Switzerland in 2008 and was staff physician and attending neurologist at a neurological rehabilitation hospital in Switzerland until 02/2009.

    His doctoral thesis was awarded "summa cum laude" from the Johann-Wolfgang Goethe University, Frankfurt/Main, Germany in 1997. He is a recipient of the Helmut Bauer Award for MS research from the University of Göttingen, Germany. His work is or was supported by the NIH/NINDS, the National Multiple Sclerosis Society, The Nancy Davis Foundation for MS Research, Small Ventures USA/Brass Family Foundation, through an endowment from the Rachleff Family Foundation, and through scientific collaborations with industry (Roche, Genentech, Pfizer).

    Dr. von Büdingen is a clinician-scientist and was full-time faculty and Debbie and Andy Rachleff Distinguished Professor in Neurology III at UCSF from 2009 to 2016. His research focused on B cell and antibody mediated immunity in Multiple Sclerois and related disorders. He was a clinical provider in the UCSF MS Center from 2009 to 2014.

    In March 2016 Dr. von Büdingen moved to Basel, Switzerland for a position in translational medicine (Neuroscience). He retains an adjunct faculty position at UCSF.

    Collapse Research 
    Collapse Research Activities and Funding
    Disease relevance of CD20 expression on T cells in multiple sclerosis patients
    NIH/NINDS R01NS092835Aug 15, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Antibody Mediated Autoimmunity in Neuromyelitis Optica
    NIH K02NS072288Jun 15, 2011 - May 31, 2016
    Role: Principal Investigator
    NIH F32NS010996Sep 28, 1999
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. von Büdingen HC, Mei F, Greenfield A, Jahn S, Shen YA, Reid HH, McKemy DD, Chan JR. The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry. J Cell Biol. 2015 Sep 14; 210(6):891-8. PMID: 26347141; PMCID: PMC4576870 [Available on 03/14/16].
    2. Palanichamy A, Apeltsin L, Kuo TC, Sirota M, Wang S, Pitts SJ, Sundar PD, Telman D, Zhao LZ, Derstine M, Abounasr A, Hauser SL, von Büdingen HC. Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis. Sci Transl Med. 2014 Aug 6; 6(248):248ra106. PMID: 25100740; PMCID: PMC4176763.
    3. Palanichamy A, Jahn S, Nickles D, Derstine M, Abounasr A, Hauser SL, Baranzini SE, Leppert D, von Büdingen HC. Rituximab efficiently depletes increased CD20-expressing T cells in multiple sclerosis patients. J Immunol. 2014 Jul 15; 193(2):580-6. PMID: 24928997; PMCID: PMC4082756.
    4. Bankoti J, Apeltsin L, Hauser SL, Allen S, Albertolle ME, Witkowska HE, von Büdingen HC. In multiple sclerosis, oligoclonal bands connect to peripheral B-cell responses. Ann Neurol. 2014 Feb; 75(2):266-76. PMID: 24375699; PMCID: PMC3961546.
    5. von Büdingen HC, Kuo TC, Sirota M, van Belle CJ, Apeltsin L, Glanville J, Cree BA, Gourraud PA, Schwartzburg A, Huerta G, Telman D, Sundar PD, Casey T, Cox DR, Hauser SL. B cell exchange across the blood-brain barrier in multiple sclerosis. J Clin Invest. 2012 Dec; 122(12):4533-43. PMID: 23160197; PMCID: PMC3533544.
    6. Glanville J, Kuo TC, von Büdingen HC, Guey L, Berka J, Sundar PD, Huerta G, Mehta GR, Oksenberg JR, Hauser SL, Cox DR, Rajpal A, Pons J. Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20066-71. PMID: 22123975; PMCID: PMC3250199.
    7. Menge T, Lalive PH, von Büdingen HC, Genain CP. Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis. J Neuroinflammation. 2011; 8:161. PMID: 22093619; PMCID: PMC3238300.
    8. von Büdingen HC, Bar-Or A, Zamvil SS. B cells in multiple sclerosis: connecting the dots. Curr Opin Immunol. 2011 Dec; 23(6):713-20. PMID: 21983151; PMCID: PMC4188435.
    9. von Büdingen HC, Gulati M, Kuenzle S, Fischer K, Rupprecht TA, Goebels N. Clonally expanded plasma cells in the cerebrospinal fluid of patients with central nervous system autoimmune demyelination produce "oligoclonal bands". J Neuroimmunol. 2010 Jan 25; 218(1-2):134-9. PMID: 19900722.
      View in: PubMed
    10. Harrer MD, von Büdingen HC, Stoppini L, Alliod C, Pouly S, Fischer K, Goebels N. Live imaging of remyelination after antibody-mediated demyelination in an ex-vivo model for immune mediated CNS damage. Exp Neurol. 2009 Apr; 216(2):431-8. PMID: 19320002.
      View in: PubMed
    11. von Büdingen HC, Harrer MD, Kuenzle S, Meier M, Goebels N. Clonally expanded plasma cells in the cerebrospinal fluid of MS patients produce myelin-specific antibodies. Eur J Immunol. 2008 Jul; 38(7):2014-23. PMID: 18521957.
      View in: PubMed
    12. Menge T, Weber MS, Hemmer B, Kieseier BC, von Büdingen HC, Warnke C, Zamvil SS, Boster A, Khan O, Hartung HP, Stüve O. Disease-modifying agents for multiple sclerosis: recent advances and future prospects. Drugs. 2008; 68(17):2445-68. PMID: 19016573.
      View in: PubMed
    13. Menge T, von Büdingen HC, Lalive PH, Genain CP. Relevant antibody subsets against MOG recognize conformational epitopes exclusively exposed in solid-phase ELISA. Eur J Immunol. 2007 Nov; 37(11):3229-39. PMID: 17918203.
      View in: PubMed
    14. Kuenzle S, von Büdingen HC, Meier M, Harrer MD, Urich E, Becher B, Goebels N. Pathogen specificity and autoimmunity are distinct features of antigen-driven immune responses in neuroborreliosis. Infect Immun. 2007 Aug; 75(8):3842-7. PMID: 17517881; PMCID: PMC1951992.
    15. Stüve O, Youssef S, Weber MS, Nessler S, von Büdingen HC, Hemmer B, Prod'homme T, Sobel RA, Steinman L, Zamvil SS. Immunomodulatory synergy by combination of atorvastatin and glatiramer acetate in treatment of CNS autoimmunity. J Clin Invest. 2006 Apr; 116(4):1037-44. PMID: 16543951; PMCID: PMC1401481.
    16. von Büdingen HC, Menge T, Hauser SL, Genain CP. Restrictive and diversifying elements of the anti-myelin/oligodendrocyte glycoprotein antibody response in primate experimental allergic encephalomyelitis. Immunogenetics. 2006 Apr; 58(2-3):122-8. PMID: 16528499.
      View in: PubMed
    17. Lalive PH, Menge T, Delarasse C, Della Gaspera B, Pham-Dinh D, Villoslada P, von Büdingen HC, Genain CP. Antibodies to native myelin oligodendrocyte glycoprotein are serologic markers of early inflammation in multiple sclerosis. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2280-5. PMID: 16461459; PMCID: PMC1413723.
    18. von Büdingen HC, Staudacher T, von Büdingen HJ. Ultrasound diagnostics of the vertebrobasilar system. Front Neurol Neurosci. 2006; 21:57-69. PMID: 17290126.
      View in: PubMed
    19. Menge T, Lalive PH, von Büdingen HC, Cree B, Hauser SL, Genain CP. Antibody responses against galactocerebroside are potential stage-specific biomarkers in multiple sclerosis. J Allergy Clin Immunol. 2005 Aug; 116(2):453-9. PMID: 16083805.
      View in: PubMed
    20. Menge T, von Büdingen HC, Zamvil SS, Hartung HP, Kieseier BC, Stüve O. [Statins for treatment of CNS diseases. Status report from research and clinical practice]. Nervenarzt. 2005 Apr; 76(4):426-37. PMID: 15448914.
      View in: PubMed
    21. von Büdingen HC, Hauser SL, Ouallet JC, Tanuma N, Menge T, Genain CP. Frontline: Epitope recognition on the myelin/oligodendrocyte glycoprotein differentially influences disease phenotype and antibody effector functions in autoimmune demyelination. Eur J Immunol. 2004 Aug; 34(8):2072-83. PMID: 15259004.
      View in: PubMed
    22. von Büdingen HC, Skulina C. Following the tracks of immune responses. Trends Biotechnol. 2003 Oct; 21(10):415-7. PMID: 14512223.
      View in: PubMed
    23. Stüve O, Cree BC, von Büdingen HC, Yousef S, Bowen JD, Genain CP, Hauser SL, Steinman L, Zamvil SS. Approved and future pharmacotherapy for multiple sclerosis. Neurologist. 2002 Sep; 8(5):290-301. PMID: 12803676.
      View in: PubMed
    24. von Büdingen HC, Hauser SL, Fuhrmann A, Nabavi CB, Lee JI, Genain CP. Molecular characterization of antibody specificities against myelin/oligodendrocyte glycoprotein in autoimmune demyelination. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8207-12. PMID: 12060766; PMCID: PMC123046.
    25. von Büdingen HC, Hauser SL, Nabavi CB, Genain CP. Characterization of the expressed immunoglobulin IGHV repertoire in the New World marmoset Callithrix jacchus. Immunogenetics. 2001 Sep; 53(7):557-63. PMID: 11685468.
      View in: PubMed
    26. von Büdingen HC, Tanuma N, Villoslada P, Ouallet JC, Hauser SL, Genain CP. Immune responses against the myelin/oligodendrocyte glycoprotein in experimental autoimmune demyelination. J Clin Immunol. 2001 May; 21(3):155-70. PMID: 11403222.
      View in: PubMed
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