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Hakan Cakmak, MD

Title(s)Assistant Professor, Ob/Gyn, Reproductive Sciences
SchoolSchool of Medicine
Phone415-353-3040
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    Dr. Hakan Cakmak received his medical degree from Istanbul University, Cerrahpasa School of Medicine, Turkey. He completed his residency in Obstetrics and Gynecology at Yale University. He subsequently received his fellowship training in Reproductive Endocrinology and Infertility at University of California, San Francisco. Dr. Cakmak is board certified in Obstetrics and Gynecology, and is a member of the American Society for Reproductive Medicine and Society of Reproductive Endocrinology and Infertility.

    Dr. Cakmak has special interest and clinical expertise in assisted reproduction, fertility preservation, endometriosis, pelvic pain and minimally invasive surgery including laparoscopic/hysteroscopic surgery. He has over 40 publications in leading scientific journals in the fields of infertility, assisted reproduction, fertility preservation, assessment of egg quality, endometriosis and implantation. His current research is focused on the investigation of the regulation of gene expression during egg and early embryo development, and the prevention of toxic effects of cancer treatments on the ovary.

    Dr. Cakmak is the recipient of multiple awards for clinical excellence and research including: the American Society for Reproductive Medicine Fertility Preservation Special Interest Group’s Prize Paper Award, Yale University John J. Meehan–Clifford R. Miller Award for academic excellence, Yale University “Resident of Excellence Award” for research, and the The Society of Laparoendoscopic Surgeons’ Outstanding Laparoendoscopic Resident Surgeon Award. In addition, his work on infertility has received two President’s Presenter Awards from the Society for Gynecologic Investigation.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wald K, Cakmak H, Mok-Lin E, Cedars M, Rosen M, Letourneau J. Back-to-back random-start ovarian stimulation prior to chemotherapy to maximize oocyte yield. J Assist Reprod Genet. 2019 Jun; 36(6):1161-1168. PMID: 31127475.
      View in: PubMed
    2. Wald K, Cakmak H, Noel M. mTOR inhibitor sirolimus negatively impacts in vitro fertilization outcomes. J Assist Reprod Genet. 2019 May; 36(5):947-950. PMID: 30911930.
      View in: PubMed
    3. Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ. Large Differences in Small RNA Composition Between Human Biofluids. Cell Rep. 2018 Oct 30; 25(5):1346-1358. PMID: 30380423.
      View in: PubMed
    4. Anaya Y, Mata DA, Letourneau J, Cakmak H, Cedars MI, Rosen MP. Author Correction: A novel oocyte maturation trigger using 1500 IU of human chorionic gonadotropin plus 450 IU of follicle-stimulating hormone may decrease ovarian hyperstimulation syndrome across all in vitro fertilization stimulation protocols. J Assist Reprod Genet. 2018 02; 35(2):309. PMID: 29178020.
      View in: PubMed
    5. Anaya Y, Mata DA, Letourneau J, Cakmak H, Cedars MI, Rosen MP. A novel oocyte maturation trigger using 1500 IU of human chorionic gonadotropin plus 450 IU of follicle-stimulating hormone may decrease ovarian hyperstimulation syndrome across all in vitro fertilization stimulation protocols. J Assist Reprod Genet. 2018 Feb; 35(2):297-307. PMID: 29086322.
      View in: PubMed
    6. Herndon CN, Anaya Y, Noel M, Cakmak H, Cedars MI. Outcomes from a university-based low-cost in vitro fertilization program providing access to care for a low-resource socioculturally diverse urban community. Fertil Steril. 2017 10; 108(4):642-649.e4. PMID: 28874259.
      View in: PubMed
    7. Cakmak H, Seval-Celik Y, Arlier S, Guzeloglu-Kayisli O, Schatz F, Arici A, Kayisli UA. p38 Mitogen-Activated Protein Kinase is Involved in the Pathogenesis of Endometriosis by Modulating Inflammation, but not Cell Survival. Reprod Sci. 2018 04; 25(4):587-597. PMID: 28845752.
      View in: PubMed
    8. Letourneau JM, Cakmak H, Quinn M, Sinha N, I Cedars M, Rosen MP. Long-term hormonal contraceptive use is associated with a reversible suppression of antral follicle count and a break from hormonal contraception may improve oocyte yield. J Assist Reprod Genet. 2017 Sep; 34(9):1137-1144. PMID: 28669055.
      View in: PubMed
    9. Quinn MM, Cakmak H, Letourneau JM, Cedars MI, Rosen MP. Response to ovarian stimulation is not impacted by a breast cancer diagnosis. Hum Reprod. 2017 03 01; 32(3):568-574. PMID: 28122888.
      View in: PubMed
    10. Cakmak H, Franciosi F, Zamah AM, Cedars MI, Conti M. Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):2424-9. PMID: 26864200.
      View in: PubMed
    11. Cakmak H, Rosen MP. Random-start ovarian stimulation in patients with cancer. Curr Opin Obstet Gynecol. 2015 Jun; 27(3):215-21. PMID: 25919235.
      View in: PubMed
    12. Alawadhi F, Du H, Cakmak H, Taylor HS. Bone Marrow-Derived Stem Cell (BMDSC) transplantation improves fertility in a murine model of Asherman's syndrome. PLoS One. 2014; 9(5):e96662. PMID: 24819371.
      View in: PubMed
    13. Cakmak H, Tran ND, Zamah AM, Cedars MI, Rosen MP. A novel "delayed start" protocol with gonadotropin-releasing hormone antagonist improves outcomes in poor responders. Fertil Steril. 2014 May; 101(5):1308-14. PMID: 24636401.
      View in: PubMed
    14. Chen J, Torcia S, Xie F, Lin CJ, Cakmak H, Franciosi F, Horner K, Onodera C, Song JS, Cedars MI, Ramalho-Santos M, Conti M. Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes. Nat Cell Biol. 2013 Dec; 15(12):1415-23. PMID: 24270888.
      View in: PubMed
    15. Cakmak H, Katz A, Cedars MI, Rosen MP. Effective method for emergency fertility preservation: random-start controlled ovarian stimulation. Fertil Steril. 2013 Dec; 100(6):1673-80. PMID: 23987516.
      View in: PubMed
    16. Cakmak H, Rosen MP. Ovarian stimulation in cancer patients. Fertil Steril. 2013 May; 99(6):1476-84. PMID: 23635348.
      View in: PubMed
    17. Cakmak H, Fujimoto VY, Zamah AM, Rosen MP, Tran ND, Cedars MI, Rinaudo PF. Metaphase II (MII) oocytes obtained at different time points in the same in vitro fertilization cycle. J Assist Reprod Genet. 2012 Nov; 29(11):1203-5. PMID: 22941385.
      View in: PubMed
    18. Cakmak H, Basar M, Seval-Celik Y, Osteen KG, Duleba AJ, Taylor HS, Lockwood CJ, Arici A. Statins inhibit monocyte chemotactic protein 1 expression in endometriosis. Reprod Sci. 2012 Jun; 19(6):572-9. PMID: 22267540.
      View in: PubMed
    19. Zuckerwise LC, Cakmak H, Sfakianaki AK. Uterine dehiscence in early second trimester. Obstet Gynecol. 2011 Aug; 118(2 Pt 2):497-500. PMID: 21768866.
      View in: PubMed
    20. Cakmak H, Taylor HS. Implantation failure: molecular mechanisms and clinical treatment. Hum Reprod Update. 2011 Mar-Apr; 17(2):242-53. PMID: 20729534.
      View in: PubMed
    21. Cakmak H, Taylor HS. Molecular mechanisms of treatment resistance in endometriosis: the role of progesterone-hox gene interactions. Semin Reprod Med. 2010 Jan; 28(1):69-74. PMID: 20104430.
      View in: PubMed
    22. Cinar O, Seval Y, Uz YH, Cakmak H, Ulukus M, Kayisli UA, Arici A. Differential regulation of Akt phosphorylation in endometriosis. Reprod Biomed Online. 2009 Dec; 19(6):864-71. PMID: 20031030.
      View in: PubMed
    23. Cakmak H, Guzeloglu-Kayisli O, Kayisli UA, Arici A. Immune-endocrine interactions in endometriosis. Front Biosci (Elite Ed). 2009 Jun 01; 1:429-43. PMID: 19482657.
      View in: PubMed
    24. Matalliotakis I, Cakmak H, Goumenou A, Sifakis S, Ziogos E, Arici A. ABO and Rh blood groups distribution in patients with endometriosis. Arch Gynecol Obstet. 2009 Dec; 280(6):917-9. PMID: 19301022.
      View in: PubMed
    25. Matalliotakis IM, Cakmak H, Krasonikolakis GD, Dermitzaki D, Fragouli Y, Vlastos G, Arici A. Endometriosis related to family history of malignancies in the Yale series. Surg Oncol. 2010 Mar; 19(1):33-7. PMID: 19299121.
      View in: PubMed
    26. Murk W, Atabekoglu CS, Cakmak H, Heper A, Ensari A, Kayisli UA, Arici A. Extracellularly signal-regulated kinase activity in the human endometrium: possible roles in the pathogenesis of endometriosis. J Clin Endocrinol Metab. 2008 Sep; 93(9):3532-40. PMID: 18559923.
      View in: PubMed
    27. Matalliotakis I, Cakmak H, Sakkas D, Mahutte N, Koumantakis G, Arici A. Impact of body mass index on IVF and ICSI outcome: a retrospective study. Reprod Biomed Online. 2008 Jun; 16(6):778-83. PMID: 18549686.
      View in: PubMed
    28. Kizilay G, Cakmak H, Yen CF, Atabekoglu C, Arici A, Kayisli UA. Expression and regulation of c-Jun N-terminal kinase (JNK) in endometrial cells in vivo and in vitro. Histochem Cell Biol. 2008 Oct; 130(4):761-71. PMID: 18506470.
      View in: PubMed
    29. Matalliotakis IM, Cakmak H, Mahutte N, Goumenou AG, Koumantakis G, Arici A. The familial risk of breast cancer in women with endometriosis from Yale series. Surg Oncol. 2008 Dec; 17(4):289-93. PMID: 18456491.
      View in: PubMed
    30. Matalliotakis IM, Arici A, Cakmak H, Goumenou AG, Koumantakis G, Mahutte NG. Familial aggregation of endometriosis in the Yale Series. Arch Gynecol Obstet. 2008 Dec; 278(6):507-11. PMID: 18449556.
      View in: PubMed
    31. Matalliotakis I, Cakmak H, Dermitzaki D, Zervoudis S, Goumenou A, Fragouli Y. Increased rate of endometriosis and spontaneous abortion in an in vitro fertilization program: no correlation with epidemiological factors. Gynecol Endocrinol. 2008 Apr; 24(4):194-8. PMID: 18382905.
      View in: PubMed
    32. Matalliotakis IM, Cakmak H, Koumantakis EE, Margariti A, Neonaki M, Goumenou AG. Arguments for a left lateral predisposition of endometrioma. Fertil Steril. 2009 Apr; 91(4):975-8. PMID: 18353324.
      View in: PubMed
    33. Matalliotakis IM, Cakmak H, Fragouli YG, Goumenou AG, Mahutte NG, Arici A. Epidemiological characteristics in women with and without endometriosis in the Yale series. Arch Gynecol Obstet. 2008 May; 277(5):389-93. PMID: 17922285.
      View in: PubMed
    34. Matalliotakis IM, Cakmak H, Mahutte N, Fragouli Y, Arici A, Sakkas D. Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility. Fertil Steril. 2007 Dec; 88(6):1568-72. PMID: 17349642.
      View in: PubMed
    35. Seli E, Guzeloglu-Kayisli O, Cakmak H, Kayisli UA, Selam B, Arici A. Estradiol increases apoptosis in human coronary artery endothelial cells by up-regulating Fas and Fas ligand expression. J Clin Endocrinol Metab. 2006 Dec; 91(12):4995-5001. PMID: 17003091.
      View in: PubMed
    36. Ulukus M, Cakmak H, Arici A. The role of endometrium in endometriosis. J Soc Gynecol Investig. 2006 Oct; 13(7):467-76. PMID: 16990031.
      View in: PubMed
    37. Matalliotakis IM, Cakmak H, Fragouli Y, Kourtis A, Arici A, Huszar G. Increased IL-18 levels in seminal plasma of infertile men with genital tract infections. Am J Reprod Immunol. 2006 Jun; 55(6):428-33. PMID: 16674600.
      View in: PubMed
    38. Seval Y, Cakmak H, Kayisli UA, Arici A. Estrogen-mediated regulation of p38 mitogen-activated protein kinase in human endometrium. J Clin Endocrinol Metab. 2006 Jun; 91(6):2349-57. PMID: 16522698.
      View in: PubMed
    39. Seli E, Kayisli UA, Cakmak H, Bukulmez O, Bildirici I, Guzeloglu-Kayisli O, Arici A. Removal of hydrosalpinges increases endometrial leukaemia inhibitory factor (LIF) expression at the time of the implantation window. Hum Reprod. 2005 Nov; 20(11):3012-7. PMID: 16024536.
      View in: PubMed
    40. Berkkanoglu M, Zhang L, Ulukus M, Cakmak H, Kayisli UA, Kursun S, Arici A. Inhibition of chemokines prevents intraperitoneal adhesions in mice. Hum Reprod. 2005 Nov; 20(11):3047-52. PMID: 16006464.
      View in: PubMed
    41. Cakmak H, Schatz F, Huang ST, Buchwalder L, Rahman M, Arici A, Lockwood CJ. Progestin suppresses thrombin- and interleukin-1beta-induced interleukin-11 production in term decidual cells: implications for preterm delivery. J Clin Endocrinol Metab. 2005 Sep; 90(9):5279-86. PMID: 15998775.
      View in: PubMed
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