Hakan Cakmak, MD

Title(s)Associate Professor, Ob/Gyn, Reproductive Sciences
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSE
San Francisco CA 94143
Phone415-353-3040
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    Dr. Hakan Cakmak received his medical degree from Istanbul University, Cerrahpasa School of Medicine, Turkey. He completed his residency in Obstetrics and Gynecology at Yale University. He subsequently received his fellowship training in Reproductive Endocrinology and Infertility at University of California, San Francisco. Dr. Cakmak is board certified in Obstetrics and Gynecology, and is a member of the American Society for Reproductive Medicine and Society of Reproductive Endocrinology and Infertility.

    Dr. Cakmak has special interest and clinical expertise in assisted reproduction, fertility preservation, endometriosis, pelvic pain and minimally invasive surgery including laparoscopic/hysteroscopic surgery. He has over 40 publications in leading scientific journals in the fields of infertility, assisted reproduction, fertility preservation, assessment of egg quality, endometriosis and implantation. His current research is focused on the investigation of the regulation of gene expression during egg and early embryo development, and the prevention of toxic effects of cancer treatments on the ovary.

    Dr. Cakmak is the recipient of multiple awards for clinical excellence and research including: the American Society for Reproductive Medicine Fertility Preservation Special Interest Group’s Prize Paper Award, Yale University John J. Meehan–Clifford R. Miller Award for academic excellence, Yale University “Resident of Excellence Award” for research, and the The Society of Laparoendoscopic Surgeons’ Outstanding Laparoendoscopic Resident Surgeon Award. In addition, his work on infertility has received two President’s Presenter Awards from the Society for Gynecologic Investigation.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Triggering with 1,500 IU of human chorionic gonadotropin plus follicle-stimulating hormone compared to a standard human chorionic gonadotropin trigger dose for oocyte competence in in vitro fertilization cycles: a randomized, double-blinded, controlled noninferiority trial. Fertil Steril. 2022 Aug; 118(2):266-278. Anaya Y, Cakmak H, Mata DA, Letourneau J, Zhang L, Lenhart N, Juarez-Hernandez F, Jalalian L, Cedars MI, Rosen M. PMID: 35705380.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. When is the right time to stop autologous in vitro fertilization treatment in poor responders? Fertil Steril. 2022 04; 117(4):682-687. Cakmak H. PMID: 35367012.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Back-to-back random-start ovarian stimulation prior to chemotherapy to maximize oocyte yield. J Assist Reprod Genet. 2019 Jun; 36(6):1161-1168. Wald K, Cakmak H, Mok-Lin E, Cedars M, Rosen M, Letourneau J. PMID: 31127475; PMCID: PMC6603104.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    4. mTOR inhibitor sirolimus negatively impacts in vitro fertilization outcomes. J Assist Reprod Genet. 2019 May; 36(5):947-950. Wald K, Cakmak H, Noel M. PMID: 30911930; PMCID: PMC6541660.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Large Differences in Small RNA Composition Between Human Biofluids. Cell Rep. 2018 10 30; 25(5):1346-1358. Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ. PMID: 30380423; PMCID: PMC6261476.
      View in: PubMed   Mentions: 74     Fields:    Translation:Humans
    6. Author Correction: A novel oocyte maturation trigger using 1500 IU of human chorionic gonadotropin plus 450 IU of follicle-stimulating hormone may decrease ovarian hyperstimulation syndrome across all in vitro fertilization stimulation protocols. J Assist Reprod Genet. 2018 02; 35(2):309. Anaya Y, Mata DA, Letourneau J, Cakmak H, Cedars MI, Rosen MP. PMID: 29178020; PMCID: PMC5845045.
      View in: PubMed   Mentions:    Fields:    
    7. A novel oocyte maturation trigger using 1500 IU of human chorionic gonadotropin plus 450 IU of follicle-stimulating hormone may decrease ovarian hyperstimulation syndrome across all in vitro fertilization stimulation protocols. J Assist Reprod Genet. 2018 Feb; 35(2):297-307. Anaya Y, Mata DA, Letourneau J, Cakmak H, Cedars MI, Rosen MP. PMID: 29086322; PMCID: PMC5845042.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    8. Outcomes from a university-based low-cost in vitro fertilization program providing access to care for a low-resource socioculturally diverse urban community. Fertil Steril. 2017 10; 108(4):642-649.e4. Herndon CN, Anaya Y, Noel M, Cakmak H, Cedars MI. PMID: 28874259.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    9. p38 Mitogen-Activated Protein Kinase is Involved in the Pathogenesis of Endometriosis by Modulating Inflammation, but not Cell Survival. Reprod Sci. 2018 04; 25(4):587-597. Cakmak H, Seval-Celik Y, Arlier S, Guzeloglu-Kayisli O, Schatz F, Arici A, Kayisli UA. PMID: 28845752.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    10. Long-term hormonal contraceptive use is associated with a reversible suppression of antral follicle count and a break from hormonal contraception may improve oocyte yield. J Assist Reprod Genet. 2017 Sep; 34(9):1137-1144. Letourneau JM, Cakmak H, Quinn M, Sinha N, I Cedars M, Rosen MP. PMID: 28669055; PMCID: PMC5581794.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    11. Response to ovarian stimulation is not impacted by a breast cancer diagnosis. Hum Reprod. 2017 03 01; 32(3):568-574. Quinn MM, Cakmak H, Letourneau JM, Cedars MI, Rosen MP. PMID: 28122888.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    12. Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):2424-9. Cakmak H, Franciosi F, Zamah AM, Cedars MI, Conti M. PMID: 26864200; PMCID: PMC4780620.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    13. Random-start ovarian stimulation in patients with cancer. Curr Opin Obstet Gynecol. 2015 Jun; 27(3):215-21. Cakmak H, Rosen MP. PMID: 25919235.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    14. Bone Marrow-Derived Stem Cell (BMDSC) transplantation improves fertility in a murine model of Asherman's syndrome. PLoS One. 2014; 9(5):e96662. Alawadhi F, Du H, Cakmak H, Taylor HS. PMID: 24819371; PMCID: PMC4018329.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    15. A novel "delayed start" protocol with gonadotropin-releasing hormone antagonist improves outcomes in poor responders. Fertil Steril. 2014 May; 101(5):1308-14. Cakmak H, Tran ND, Zamah AM, Cedars MI, Rosen MP. PMID: 24636401; PMCID: PMC4604751.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    16. Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes. Nat Cell Biol. 2013 Dec; 15(12):1415-23. Chen J, Torcia S, Xie F, Lin CJ, Cakmak H, Franciosi F, Horner K, Onodera C, Song JS, Cedars MI, Ramalho-Santos M, Conti M. PMID: 24270888; PMCID: PMC4066669.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    17. Effective method for emergency fertility preservation: random-start controlled ovarian stimulation. Fertil Steril. 2013 Dec; 100(6):1673-80. Cakmak H, Katz A, Cedars MI, Rosen MP. PMID: 23987516.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    18. Ovarian stimulation in cancer patients. Fertil Steril. 2013 May; 99(6):1476-84. Cakmak H, Rosen MP. PMID: 23635348.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    19. Metaphase II (MII) oocytes obtained at different time points in the same in vitro fertilization cycle. J Assist Reprod Genet. 2012 Nov; 29(11):1203-5. Cakmak H, Fujimoto VY, Zamah AM, Rosen MP, Tran ND, Cedars MI, Rinaudo PF. PMID: 22941385; PMCID: PMC3510378.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    20. Statins inhibit monocyte chemotactic protein 1 expression in endometriosis. Reprod Sci. 2012 Jun; 19(6):572-9. Cakmak H, Basar M, Seval-Celik Y, Osteen KG, Duleba AJ, Taylor HS, Lockwood CJ, Arici A. PMID: 22267540; PMCID: PMC3439122.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    21. Uterine dehiscence in early second trimester. Obstet Gynecol. 2011 Aug; 118(2 Pt 2):497-500. Zuckerwise LC, Cakmak H, Sfakianaki AK. PMID: 21768866.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Implantation failure: molecular mechanisms and clinical treatment. Hum Reprod Update. 2011 Mar-Apr; 17(2):242-53. Cakmak H, Taylor HS. PMID: 20729534; PMCID: PMC3039220.
      View in: PubMed   Mentions: 97     Fields:    Translation:Humans
    23. Molecular mechanisms of treatment resistance in endometriosis: the role of progesterone-hox gene interactions. Semin Reprod Med. 2010 Jan; 28(1):69-74. Cakmak H, Taylor HS. PMID: 20104430; PMCID: PMC3107856.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    24. Differential regulation of Akt phosphorylation in endometriosis. Reprod Biomed Online. 2009 Dec; 19(6):864-71. Cinar O, Seval Y, Uz YH, Cakmak H, Ulukus M, Kayisli UA, Arici A. PMID: 20031030.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    25. Immune-endocrine interactions in endometriosis. Front Biosci (Elite Ed). 2009 06 01; 1(2):429-43. Cakmak H, Guzeloglu-Kayisli O, Kayisli UA, Arici A. PMID: 19482657.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    26. ABO and Rh blood groups distribution in patients with endometriosis. Arch Gynecol Obstet. 2009 Dec; 280(6):917-9. Matalliotakis I, Cakmak H, Goumenou A, Sifakis S, Ziogos E, Arici A. PMID: 19301022.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    27. Endometriosis related to family history of malignancies in the Yale series. Surg Oncol. 2010 Mar; 19(1):33-7. Matalliotakis IM, Cakmak H, Krasonikolakis GD, Dermitzaki D, Fragouli Y, Vlastos G, Arici A. PMID: 19299121.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    28. Extracellularly signal-regulated kinase activity in the human endometrium: possible roles in the pathogenesis of endometriosis. J Clin Endocrinol Metab. 2008 Sep; 93(9):3532-40. Murk W, Atabekoglu CS, Cakmak H, Heper A, Ensari A, Kayisli UA, Arici A. PMID: 18559923.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    29. Impact of body mass index on IVF and ICSI outcome: a retrospective study. Reprod Biomed Online. 2008 Jun; 16(6):778-83. Matalliotakis I, Cakmak H, Sakkas D, Mahutte N, Koumantakis G, Arici A. PMID: 18549686.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    30. Expression and regulation of c-Jun N-terminal kinase (JNK) in endometrial cells in vivo and in vitro. Histochem Cell Biol. 2008 Oct; 130(4):761-71. Kizilay G, Cakmak H, Yen CF, Atabekoglu C, Arici A, Kayisli UA. PMID: 18506470.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    31. The familial risk of breast cancer in women with endometriosis from Yale series. Surg Oncol. 2008 Dec; 17(4):289-93. Matalliotakis IM, Cakmak H, Mahutte N, Goumenou AG, Koumantakis G, Arici A. PMID: 18456491.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    32. Familial aggregation of endometriosis in the Yale Series. Arch Gynecol Obstet. 2008 Dec; 278(6):507-11. Matalliotakis IM, Arici A, Cakmak H, Goumenou AG, Koumantakis G, Mahutte NG. PMID: 18449556.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    33. Increased rate of endometriosis and spontaneous abortion in an in vitro fertilization program: no correlation with epidemiological factors. Gynecol Endocrinol. 2008 Apr; 24(4):194-8. Matalliotakis I, Cakmak H, Dermitzaki D, Zervoudis S, Goumenou A, Fragouli Y. PMID: 18382905.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    34. Arguments for a left lateral predisposition of endometrioma. Fertil Steril. 2009 Apr; 91(4):975-8. Matalliotakis IM, Cakmak H, Koumantakis EE, Margariti A, Neonaki M, Goumenou AG. PMID: 18353324.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    35. Epidemiological characteristics in women with and without endometriosis in the Yale series. Arch Gynecol Obstet. 2008 May; 277(5):389-93. Matalliotakis IM, Cakmak H, Fragouli YG, Goumenou AG, Mahutte NG, Arici A. PMID: 17922285.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    36. Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility. Fertil Steril. 2007 Dec; 88(6):1568-72. Matalliotakis IM, Cakmak H, Mahutte N, Fragouli Y, Arici A, Sakkas D. PMID: 17349642.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    37. Estradiol increases apoptosis in human coronary artery endothelial cells by up-regulating Fas and Fas ligand expression. J Clin Endocrinol Metab. 2006 Dec; 91(12):4995-5001. Seli E, Guzeloglu-Kayisli O, Cakmak H, Kayisli UA, Selam B, Arici A. PMID: 17003091.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    38. The role of endometrium in endometriosis. J Soc Gynecol Investig. 2006 Oct; 13(7):467-76. Ulukus M, Cakmak H, Arici A. PMID: 16990031.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    39. Increased IL-18 levels in seminal plasma of infertile men with genital tract infections. Am J Reprod Immunol. 2006 Jun; 55(6):428-33. Matalliotakis IM, Cakmak H, Fragouli Y, Kourtis A, Arici A, Huszar G. PMID: 16674600.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    40. Estrogen-mediated regulation of p38 mitogen-activated protein kinase in human endometrium. J Clin Endocrinol Metab. 2006 Jun; 91(6):2349-57. Seval Y, Cakmak H, Kayisli UA, Arici A. PMID: 16522698.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    41. Removal of hydrosalpinges increases endometrial leukaemia inhibitory factor (LIF) expression at the time of the implantation window. Hum Reprod. 2005 Nov; 20(11):3012-7. Seli E, Kayisli UA, Cakmak H, Bukulmez O, Bildirici I, Guzeloglu-Kayisli O, Arici A. PMID: 16024536.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    42. Inhibition of chemokines prevents intraperitoneal adhesions in mice. Hum Reprod. 2005 Nov; 20(11):3047-52. Berkkanoglu M, Zhang L, Ulukus M, Cakmak H, Kayisli UA, Kursun S, Arici A. PMID: 16006464.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    43. Progestin suppresses thrombin- and interleukin-1beta-induced interleukin-11 production in term decidual cells: implications for preterm delivery. J Clin Endocrinol Metab. 2005 Sep; 90(9):5279-86. Cakmak H, Schatz F, Huang ST, Buchwalder L, Rahman M, Arici A, Lockwood CJ. PMID: 15998775.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
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