Hassan Lemjabbar-Alaoui, PhD

Title(s)Assistant Professor, Surgery
SchoolSchool of Medicine
Address2340 Sutter Street
San Francisco CA 94115
Phone415-476-9303
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.DOncology

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Extracellular Sulfatases As Novel Biomarkers For Early Detection of Cancer
    NIH U01CA168878Aug 16, 2012 - Jun 30, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Extracellular sulfatases as potential blood-based biomarkers for early detection of lung cancer. Exp Lung Res. 2021 May-Aug; 47(6):261-279. Yang YW, Jablons DM, Lemjabbar-Alaoui H. PMID: 33908819.
      View in: PubMed   Mentions:    Fields:    
    2. Sulfatase 2 (SULF2) Monoclonal Antibody 5D5 Suppresses Human Cholangiocarcinoma Xenograft Growth Through Regulation of a SULF2-Platelet-Derived Growth Factor Receptor Beta-Yes-Associated Protein Signaling Axis. Hepatology. 2021 Mar 18. Luo X, Campbell NA, He L, O'Brien DR, Singer MS, Lemjabbar-Alaoui H, Ahn KS, Smoot R, Torbenson MS, Rosen SD, Roberts LR. PMID: 33735525.
      View in: PubMed   Mentions:    Fields:    
    3. Development of novel monoclonal antibodies and immunoassays for sensitive and specific detection of SULF1 endosulfatase. Biochim Biophys Acta Gen Subj. 2021 02; 1865(2):129802. Yang YW, Phillips JJ, Jablons DM, Lemjabbar-Alaoui H. PMID: 33276062.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Ponatinib is a potential therapeutic approach for malignant pleural mesothelioma. Exp Lung Res. 2021 Feb; 47(1):9-25. Yang YW, Marrufo A, Chase J, Woodard GA, Jablons DM, Lemjabbar-Alaoui H. PMID: 33107354.
      View in: PubMed   Mentions:    Fields:    
    5. AMXI-5001, a novel dual parp1/2 and microtubule polymerization inhibitor for the treatment of human cancers. Am J Cancer Res. 2020; 10(8):2649-2676. Lemjabbar-Alaoui H, Peto CJ, Yang YW, Jablons DM. PMID: 32905466.
      View in: PubMed   Mentions:
    6. SULF2 Expression Is a Potential Diagnostic and Prognostic Marker in Lung Cancer. PLoS One. 2016; 11(2):e0148911. Lui NS, Yang YW, van Zante A, Buchanan P, Jablons DM, Lemjabbar-Alaoui H. PMID: 26882224.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    7. Lung cancer: Biology and treatment options. Biochim Biophys Acta. 2015 Dec; 1856(2):189-210. Lemjabbar-Alaoui H, Hassan OU, Yang YW, Buchanan P. PMID: 26297204.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimals
    8. Glycosylation alterations in lung and brain cancer. Adv Cancer Res. 2015; 126:305-44. Lemjabbar-Alaoui H, McKinney A, Yang YW, Tran VM, Phillips JJ. PMID: 25727152.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    9. SULF2, a heparan sulfate endosulfatase, is present in the blood of healthy individuals and increases in cirrhosis. Clin Chim Acta. 2015 Feb 02; 440:72-8. Singer MS, Phillips JJ, Lemjabbar-Alaoui H, Wang YQ, Wu J, Goldman R, Rosen SD. PMID: 25444749.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    10. Endosulfatases SULF1 and SULF2 limit Chlamydia muridarum infection. Cell Microbiol. 2013 Sep; 15(9):1560-71. Kim JH, Chan C, Elwell C, Singer MS, Dierks T, Lemjabbar-Alaoui H, Rosen SD, Engel JN. PMID: 23480519.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    11. SULF2 expression by immunohistochemistry and overall survival in oesophageal cancer: a cohort study. BMJ Open. 2012; 2(6). Lui NS, van Zante A, Rosen SD, Jablons DM, Lemjabbar-Alaoui H. PMID: 23180455.
      View in: PubMed   Mentions: 9     Fields:    
    12. TACE/ADAM-17 phosphorylation by PKC-epsilon mediates premalignant changes in tobacco smoke-exposed lung cells. PLoS One. 2011 Mar 15; 6(3):e17489. Lemjabbar-Alaoui H, Sidhu SS, Mengistab A, Gallup M, Basbaum C. PMID: 21423656.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    13. Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate. Expert Opin Ther Targets. 2010 Sep; 14(9):935-49. Rosen SD, Lemjabbar-Alaoui H. PMID: 20629619.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    14. EMMPRIN regulates the canonical Wnt/beta-catenin signaling pathway, a potential role in accelerating lung tumorigenesis. Oncogene. 2010 Jul 22; 29(29):4145-56. Sidhu SS, Nawroth R, Retz M, Lemjabbar-Alaoui H, Dasari V, Basbaum C. PMID: 20514014.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    15. Use of a phage display antibody to measure the enzymatic activity of the Sulfs. Methods Enzymol. 2010; 480:51-64. Uchimura K, Lemjabbar-Alaoui H, van Kuppevelt TH, Rosen SD. PMID: 20816204.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis. Oncogene. 2010 Feb 04; 29(5):635-46. Lemjabbar-Alaoui H, van Zante A, Singer MS, Xue Q, Wang YQ, Tsay D, He B, Jablons DM, Rosen SD. PMID: 19855436.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    17. Wnt and Hedgehog are critical mediators of cigarette smoke-induced lung cancer. PLoS One. 2006 Dec 20; 1:e93. Lemjabbar-Alaoui H, Dasari V, Sidhu SS, Mengistab A, Finkbeiner W, Gallup M, Basbaum C. PMID: 17183725.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    18. Epithelial-mesenchymal transition in lung cancer: is tobacco the "smoking gun"? Am J Respir Cell Mol Biol. 2006 Jul; 35(1):3-9. Dasari V, Gallup M, Lemjabbar H, Maltseva I, McNamara N. PMID: 16484682.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    19. Tobacco smoke control of mucin production in lung cells requires oxygen radicals AP-1 and JNK. J Biol Chem. 2004 Sep 10; 279(37):39085-93. Gensch E, Gallup M, Sucher A, Li D, Gebremichael A, Lemjabbar H, Mengistab A, Dasari V, Hotchkiss J, Harkema J, Basbaum C. PMID: 15262961.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    20. Viral dsRNA activates mucin transcription in airway epithelial cells. FEBS Lett. 2003 Oct 09; 553(1-2):33-8. Londhe V, McNamara N, Lemjabbar H, Basbaum C. PMID: 14550542.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    21. Tobacco smoke-induced lung cell proliferation mediated by tumor necrosis factor alpha-converting enzyme and amphiregulin. J Biol Chem. 2003 Jul 11; 278(28):26202-7. Lemjabbar H, Li D, Gallup M, Sidhu S, Drori E, Basbaum C. PMID: 12711607.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    22. Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells. Nat Med. 2002 Jan; 8(1):41-6. Lemjabbar H, Basbaum C. PMID: 11786905.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansCells
    23. Mechanisms by which gram-positive bacteria and tobacco smoke stimulate mucin induction through the epidermal growth factor receptor (EGFR). Novartis Found Symp. 2002; 248:171-6; discussion 176-80, 277-82. Basbaum C, Li D, Gensch E, Gallup M, Lemjabbar H. PMID: 12568494.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    24. The transcriptional responses of respiratory epithelial cells to Bordetella pertussis reveal host defensive and pathogen counter-defensive strategies. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13847-52. Belcher CE, Drenkow J, Kehoe B, Gingeras TR, McNamara N, Lemjabbar H, Basbaum C, Relman DA. PMID: 11087813.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    25. Control of mucin transcription by diverse injury-induced signaling pathways. Am J Respir Crit Care Med. 1999 Nov; 160(5 Pt 2):S44-8. Basbaum C, Lemjabbar H, Longphre M, Li D, Gensch E, McNamara N. PMID: 10556169.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    26. Balance between MMP-9 and TIMP-1 expressed by human bronchial epithelial cells: relevance to asthma. Ann N Y Acad Sci. 1999 Jun 30; 878:512-4. Yao PM, Lemjabbar H, D'Ortho MP, Maitre B, Gossett P, Wallaert B, Lafuma C. PMID: 10415758.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    27. Overexpression of alveolar macrophage gelatinase B (MMP-9) in patients with idiopathic pulmonary fibrosis: effects of steroid and immunosuppressive treatment. Am J Respir Cell Mol Biol. 1999 May; 20(5):903-13. Lemjabbar H, Gosset P, Lechapt-Zalcman E, Franco-Montoya ML, Wallaert B, Harf A, Lafuma C. PMID: 10226060.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    28. Contribution of 92 kDa gelatinase/type IV collagenase in bronchial inflammation during status asthmaticus. Am J Respir Crit Care Med. 1999 Apr; 159(4 Pt 1):1298-307. Lemjabbar H, Gosset P, Lamblin C, Tillie I, Hartmann D, Wallaert B, Tonnel AB, Lafuma C. PMID: 10194181.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    29. FGF protection and inhibition of human neutrophil elastase by carboxymethyl benzylamide sulfonate dextran derivatives. Int J Biol Macromol. 1996 Feb; 18(1-2):141-5. Meddahi A, Lemdjabar H, Caruelle JP, Barritault D, Hornebeck W. PMID: 8852763.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    30. Inhibition by dextran derivatives of FGF-2 plasmin-mediated degradation. Biochimie. 1995; 77(9):703-6. Meddahi A, Lemdjabar H, Caruelle JP, Barritault D, Hornebeck W. PMID: 8789459.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
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