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Hassan Lemjabbar-Alaoui, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentSurgery
Address2340 Sutter Street
San Francisco CA 94115
Phone415-476-9303
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division

    Collapse Research 
    Collapse Research Activities and Funding
    Extracellular Sulfatases As Novel Biomarkers For Early Detection of Cancer
    NIH/NCI U01CA168878Aug 16, 2012 - Jun 30, 2017
    Role: Principal Investigator

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    Collapse In The News

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lui NS, Yang YW, van Zante A, Buchanan P, Jablons DM, Lemjabbar-Alaoui H. SULF2 Expression Is a Potential Diagnostic and Prognostic Marker in Lung Cancer. PLoS One. 2016; 11(2):e0148911. PMID: 26882224.
      View in: PubMed
    2. Lemjabbar-Alaoui H, Hassan O, Yang YW, Buchanan P. Lung cancer: Biology and treatment options. Biochim Biophys Acta. 2015 Dec; 1856(2):189-210. PMID: 26297204; PMCID: PMC4663145 [Available on 12/01/16].
      View in: PubMed, PubMed Central
    3. Lemjabbar-Alaoui H, McKinney A, Yang YW, Tran VM, Phillips JJ. Glycosylation alterations in lung and brain cancer. Adv Cancer Res. 2015; 126:305-44. PMID: 25727152.
      View in: PubMed
    4. Singer MS, Phillips JJ, Lemjabbar-Alaoui H, Wang YQ, Wu J, Goldman R, Rosen SD. SULF2, a heparan sulfate endosulfatase, is present in the blood of healthy individuals and increases in cirrhosis. Clin Chim Acta. 2015 Feb 2; 440:72-8. PMID: 25444749; PMCID: PMC4305470 [Available on 02/02/16].
      View in: PubMed, PubMed Central
    5. Kim JH, Chan C, Elwell C, Singer MS, Dierks T, Lemjabbar-Alaoui H, Rosen SD, Engel JN. Endosulfatases SULF1 and SULF2 limit Chlamydia muridarum infection. Cell Microbiol. 2013 Sep; 15(9):1560-71. PMID: 23480519; PMCID: PMC3722241.
      View in: PubMed, PubMed Central
    6. Lui NS, van Zante A, Rosen SD, Jablons DM, Lemjabbar-Alaoui H. SULF2 expression by immunohistochemistry and overall survival in oesophageal cancer: a cohort study. BMJ Open. 2012; 2(6). PMID: 23180455; PMCID: PMC3532995.
      View in: PubMed, PubMed Central
    7. Lemjabbar-Alaoui H, Sidhu SS, Mengistab A, Gallup M, Basbaum C. TACE/ADAM-17 phosphorylation by PKC-epsilon mediates premalignant changes in tobacco smoke-exposed lung cells. PLoS One. 2011; 6(3):e17489. PMID: 21423656; PMCID: PMC3057966.
      View in: PubMed, PubMed Central
    8. Rosen SD, Lemjabbar-Alaoui H. Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate. Expert Opin Ther Targets. 2010 Sep; 14(9):935-49. PMID: 20629619; PMCID: PMC3126665.
      View in: PubMed, PubMed Central
    9. Sidhu SS, Nawroth R, Retz M, Lemjabbar-Alaoui H, Dasari V, Basbaum C. EMMPRIN regulates the canonical Wnt/beta-catenin signaling pathway, a potential role in accelerating lung tumorigenesis. Oncogene. 2010 Jul 22; 29(29):4145-56. PMID: 20514014.
      View in: PubMed
    10. Uchimura K, Lemjabbar-Alaoui H, van Kuppevelt TH, Rosen SD. Use of a phage display antibody to measure the enzymatic activity of the Sulfs. Methods Enzymol. 2010; 480:51-64. PMID: 20816204.
      View in: PubMed
    11. Lemjabbar-Alaoui H, van Zante A, Singer MS, Xue Q, Wang YQ, Tsay D, He B, Jablons DM, Rosen SD. Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis. Oncogene. 2010 Feb 4; 29(5):635-46. PMID: 19855436; PMCID: PMC2818095.
      View in: PubMed, PubMed Central
    12. Lemjabbar-Alaoui H, Dasari V, Sidhu SS, Mengistab A, Finkbeiner W, Gallup M, Basbaum C. Wnt and Hedgehog are critical mediators of cigarette smoke-induced lung cancer. PLoS One. 2006; 1:e93. PMID: 17183725; PMCID: PMC1762353.
      View in: PubMed, PubMed Central
    13. Dasari V, Gallup M, Lemjabbar H, Maltseva I, McNamara N. Epithelial-mesenchymal transition in lung cancer: is tobacco the "smoking gun"? Am J Respir Cell Mol Biol. 2006 Jul; 35(1):3-9. PMID: 16484682.
      View in: PubMed
    14. Gensch E, Gallup M, Sucher A, Li D, Gebremichael A, Lemjabbar H, Mengistab A, Dasari V, Hotchkiss J, Harkema J, Basbaum C. Tobacco smoke control of mucin production in lung cells requires oxygen radicals AP-1 and JNK. J Biol Chem. 2004 Sep 10; 279(37):39085-93. PMID: 15262961.
      View in: PubMed
    15. Londhe V, McNamara N, Lemjabbar H, Basbaum C. Viral dsRNA activates mucin transcription in airway epithelial cells. FEBS Lett. 2003 Oct 9; 553(1-2):33-8. PMID: 14550542.
      View in: PubMed
    16. Lemjabbar H, Li D, Gallup M, Sidhu S, Drori E, Basbaum C. Tobacco smoke-induced lung cell proliferation mediated by tumor necrosis factor alpha-converting enzyme and amphiregulin. J Biol Chem. 2003 Jul 11; 278(28):26202-7. PMID: 12711607.
      View in: PubMed
    17. Basbaum C, Li D, Gensch E, Gallup M, Lemjabbar H. Mechanisms by which gram-positive bacteria and tobacco smoke stimulate mucin induction through the epidermal growth factor receptor (EGFR). Novartis Found Symp. 2002; 248:171-6; discussion 176-80, 277-82. PMID: 12568494.
      View in: PubMed
    18. Lemjabbar H, Basbaum C. Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells. Nat Med. 2002 Jan; 8(1):41-6. PMID: 11786905.
      View in: PubMed
    19. Belcher CE, Drenkow J, Kehoe B, Gingeras TR, McNamara N, Lemjabbar H, Basbaum C, Relman DA. The transcriptional responses of respiratory epithelial cells to Bordetella pertussis reveal host defensive and pathogen counter-defensive strategies. Proc Natl Acad Sci U S A. 2000 Dec 5; 97(25):13847-52. PMID: 11087813; PMCID: PMC17664.
      View in: PubMed, PubMed Central
    20. Basbaum C, Lemjabbar H, Longphre M, Li D, Gensch E, McNamara N. Control of mucin transcription by diverse injury-induced signaling pathways. Am J Respir Crit Care Med. 1999 Nov; 160(5 Pt 2):S44-8. PMID: 10556169.
      View in: PubMed
    21. Yao PM, Lemjabbar H, D'Ortho MP, Maitre B, Gossett P, Wallaert B, Lafuma C. Balance between MMP-9 and TIMP-1 expressed by human bronchial epithelial cells: relevance to asthma. Ann N Y Acad Sci. 1999 Jun 30; 878:512-4. PMID: 10415758.
      View in: PubMed
    22. Lemjabbar H, Gosset P, Lechapt-Zalcman E, Franco-Montoya ML, Wallaert B, Harf A, Lafuma C. Overexpression of alveolar macrophage gelatinase B (MMP-9) in patients with idiopathic pulmonary fibrosis: effects of steroid and immunosuppressive treatment. Am J Respir Cell Mol Biol. 1999 May; 20(5):903-13. PMID: 10226060.
      View in: PubMed
    23. Lemjabbar H, Gosset P, Lamblin C, Tillie I, Hartmann D, Wallaert B, Tonnel AB, Lafuma C. Contribution of 92 kDa gelatinase/type IV collagenase in bronchial inflammation during status asthmaticus. Am J Respir Crit Care Med. 1999 Apr; 159(4 Pt 1):1298-307. PMID: 10194181.
      View in: PubMed
    24. Meddahi A, Lemdjabar H, Caruelle JP, Barritault D, Hornebeck W. FGF protection and inhibition of human neutrophil elastase by carboxymethyl benzylamide sulfonate dextran derivatives. Int J Biol Macromol. 1996 Feb; 18(1-2):141-5. PMID: 8852763.
      View in: PubMed
    25. Meddahi A, Lemdjabar H, Caruelle JP, Barritault D, Hornebeck W. Inhibition by dextran derivatives of FGF-2 plasmin-mediated degradation. Biochimie. 1995; 77(9):703-6. PMID: 8789459.
      View in: PubMed
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