Hengameh Shams, PhD

Title(s)Postdoctoral Scholar, Neurology
SchoolSchool of Medicine
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of California, Berkeley, BerkeleyPh.D.2016Applied Science and Technology
    Sharif University of Technology, Tehran, IranM.S.2009Physics/Biophysics
    University of Tehran, Tehran, IranB.S.2007Physics
    Collapse Awards and Honors
    American Society of Cell Biology2019Travel Grant
    University of California, Berkeley2017Berkeley Postdoctoral Association Professional Development Award
    Biophysical Society2016Biophysical Society Committee on Diversity and Inclusion Travel Award
    University of California2015  - 2016The UC Dissertation Fellowship
    University of California, Berkeley2011  - 2013Chancellor’s Fellowship

    Collapse Research 
    Collapse Research Activities and Funding
    Characterization of the interplay between T and B lymphocytes in multiple sclerosis using functional proteomics
    National Multiple Sclerosis Society FG-1807-31603Jul 1, 2019 - Jun 30, 2022
    Role: Investigator
    Characterization of the interplay between T and B lymphocytes in multiple sclerosis using functional proteomics guided by genotype-phenotype association models
    UCSF-CTSI Postdoctoral Fellowship 5TL1TR001871-04Jul 1, 2019 - Jun 30, 2020
    Role: Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans. Brain. 2022 Mar 07. Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N, University of California San Francisco MS-EPIC Team, Schaefer C, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser SL, Barcellos LF, Henry RG, Oksenberg JR. PMID: 35253861.
      View in: PubMed   Mentions:
    2. Methylation at a conserved lysine residue modulates tau assembly and cellular functions. Mol Cell Neurosci. 2022 Feb 26; 120:103707. Shams H, Matsunaga A, Ma Q, Mofrad MRK, Didonna A. PMID: 35231567.
      View in: PubMed   Mentions:
    3. A short HLA-DRA isoform binds the HLA-DR2 heterodimer on the outer domain of the peptide-binding site. Arch Biochem Biophys. 2022 Feb 24; 719:109156. Shams H, Hollenbach JA, Matsunaga A, Mofrad MRK, Oksenberg JR, Didonna A. PMID: 35218721.
      View in: PubMed   Mentions:
    4. High-Resolution Characterization of KIR Genes in a Large North American Cohort Reveals Novel Details of Structural and Sequence Diversity. Front Immunol. 2021; 12:674778. Amorim LM, Augusto DG, Nemat-Gorgani N, Montero-Martin G, Marin WM, Shams H, Dandekar R, Caillier S, Parham P, Fernández-Viña MA, Oksenberg JR, Norman PJ, Hollenbach JA. PMID: 34025673; PMCID: PMC8137979.
      View in: PubMed   Mentions:    Fields:    
    5. A splice acceptor variant in HLA-DRA affects the conformation and cellular localization of the class II DR alpha-chain. Immunology. 2021 02; 162(2):194-207. Didonna A, Damotte V, Shams H, Matsunaga A, Caillier SJ, Dandekar R, Misra MK, Mofrad MRK, Oksenberg JR, Hollenbach JA. PMID: 32986852; PMCID: PMC7808164.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23742-23750. Didonna A, Canto Puig E, Ma Q, Matsunaga A, Ho B, Caillier SJ, Shams H, Lee N, Hauser SL, Tan Q, Zamvil SS, Oksenberg JR. PMID: 32878998; PMCID: PMC7519225.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. Killer Cell Immunoglobulin-like Receptor Variants Are Associated with Protection from Symptoms Associated with More Severe Course in Parkinson Disease. J Immunol. 2020 09 01; 205(5):1323-1330. Anderson KM, Augusto DG, Dandekar R, Shams H, Zhao C, Yusufali T, Montero-Martín G, Marin WM, Nemat-Gorgani N, Creary LE, Caillier S, Mofrad MRK, Parham P, Fernández-Viña M, Oksenberg JR, Norman PJ, Hollenbach JA. PMID: 32709660; PMCID: PMC7484130.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    8. Kindlin Assists Talin to Promote Integrin Activation. Biophys J. 2020 04 21; 118(8):1977-1991. Haydari Z, Shams H, Jahed Z, Mofrad MRK. PMID: 32191864; PMCID: PMC7175420.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    9. Steric regulation of tandem calponin homology domain actin-binding affinity. Mol Biol Cell. 2019 12 15; 30(26):3112-3122. Harris AR, Belardi B, Jreij P, Wei K, Shams H, Bausch A, Fletcher DA. PMID: 31693446; PMCID: PMC6938246.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    10. Structural Basis of the Differential Binding of Engineered Knottins to Integrins αVβ3 and α5β1. Structure. 2019 09 03; 27(9):1443-1451.e6. Van Agthoven JF, Shams H, Cochran FV, Alonso JL, Kintzing JR, Garakani K, Adair BD, Xiong JP, Mofrad MRK, Cochran JR, Arnaout MA. PMID: 31353240; PMCID: PMC6726563.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    11. Sex-specific Tau methylation patterns and synaptic transcriptional alterations are associated with neural vulnerability during chronic neuroinflammation. J Autoimmun. 2019 07; 101:56-69. Didonna A, Cantó E, Shams H, Isobe N, Zhao C, Caillier SJ, Condello C, Yamate-Morgan H, Tiwari-Woodruff SK, Mofrad MRK, Hauser SL, Oksenberg JR. PMID: 31010726; PMCID: PMC6561733.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    12. The "Stressful" Life of Cell Adhesion Molecules: On the Mechanosensitivity of Integrin Adhesome. J Biomech Eng. 2018 02 01; 140(2). Shams H, Hoffman BD, Mofrad MRK. PMID: 29272321.
      View in: PubMed   Mentions: 4     Fields:    
    13. α-Actinin Induces a Kink in the Transmembrane Domain of β3-Integrin and Impairs Activation via Talin. Biophys J. 2017 Aug 22; 113(4):948-956. Shams H, Mofrad MRK. PMID: 28834730; PMCID: PMC5567591.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    14. Looking “Under the Hood” of Cellular Mechanotransduction with Computational Tools: A Systems Biomechanics Approach across Multiple Scales. ACS Biomater. Sci. Eng. . 2017; 3(11):2712-2726. .
    15. Mechanosensitive Conformation of Vinculin Regulates Its Binding to MAPK1. Biophys J. 2017 May 09; 112(9):1885-1893. Garakani K, Shams H, Mofrad MRK. PMID: 28494959; PMCID: PMC5425409.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    16. Dynamic Regulation of α-Actinin's Calponin Homology Domains on F-Actin. Biophys J. 2016 Mar 29; 110(6):1444-55. Shams H, Golji J, Garakani K, Mofrad MR. PMID: 27028653; PMCID: PMC4816760.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    17. Enhanced intracellular delivery of small molecules and drugs via non-covalent ternary dispersions of single-wall carbon nanotubes. J Mater Chem B. 2016 Feb 21; 4(7):1324-1330. Boyer PD, Shams H, Baker SL, Mofrad MRK, Islam MF, Dahl KN. PMID: 32262987.
      View in: PubMed   Mentions:    Fields:    
    18. A Disulfide Bond Is Required for the Transmission of Forces through SUN-KASH Complexes. Biophys J. 2015 Aug 04; 109(3):501-9. Jahed Z, Shams H, Mofrad MR. PMID: 26244732; PMCID: PMC4571000.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    19. Mechanisms of integrin and filamin binding and their interplay with talin during early focal adhesion formation. Integr Biol (Camb). 2015 Oct; 7(10):1285-96. Truong T, Shams H, Mofrad MR. PMID: 26156744.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    20. Mechanotransduction pathways linking the extracellular matrix to the nucleus. Int Rev Cell Mol Biol. 2014; 310:171-220. Jahed Z, Shams H, Mehrbod M, Mofrad MR. PMID: 24725427.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    21. Actin reorganization through dynamic interactions with single-wall carbon nanotubes. ACS Nano. 2014 Jan 28; 8(1):188-97. Shams H, Holt BD, Mahboobi SH, Jahed Z, Islam MF, Dahl KN, Mofrad MR. PMID: 24351114.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    22. A molecular trajectory of α-actinin activation. Biophys J. 2012 Nov 21; 103(10):2050-9. Shams H, Golji J, Mofrad MR. PMID: 23200039; PMCID: PMC3512038.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    23. Altered cell mechanics from the inside: dispersed single wall carbon nanotubes integrate with and restructure actin. J Funct Biomater. 2012 May 23; 3(2):398-417. Holt BD, Shams H, Horst TA, Basu S, Rape AD, Wang YL, Rohde GK, Mofrad MR, Islam MF, Dahl KN. PMID: 24955540; PMCID: PMC4047933.
      View in: PubMed   Mentions: 6  
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