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Huimin Geng, PhD

Title(s)Associate Professor, Laboratory Medicine
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
Phone415-502-2137
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    Collapse Biography 
    Collapse Education and Training
    University of Science and Technology of ChinaBS1999BioPhysics, School of Gifted Young
    University of Nebraska at OmahaMS2004Computer Science
    University of Nebraska Medical CenterPh.D.2008Bioinformatics
    Weill Cornell Medical CollegePostdoc2011Computational Biomedicine
    Collapse Awards and Honors
    UCSF Academic Senate2016  - 2018Pilot for Junior Investigators in Basic and Clinical/Translational Sciences

    Collapse Overview 
    Collapse Overview
    Associate Member of the UCSF Helen Diller Family Comprehensive Cancer Center (Hematopoietic Malignancies Program)

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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Surface proteomics reveals CD72 as a target for in vitro-evolved nanobody-based CAR-T cells in KMT2A/MLL1-rearranged B-ALL. Cancer Discov. 2021 Mar 16. Nix MA, Mandal K, Geng H, Paranjape N, Lin YT, Rivera J, Marcoulis M, White KL, Whitman JD, Bapat SP, Parker KR, Ramirez J, Deucher A, Phojanokong P, Steri V, Fattahi F, Hann B, Satpathy AT, Manglik A, Stieglitz E, Wiita AP. PMID: 33727310.
      View in: PubMed   Mentions:    Fields:    
    2. Author Correction: IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells. Nature. 2021 Mar 12. PMID: 33712811.
      View in: PubMed   Mentions: 1     Fields:    
    3. Tumor Metabolism and Neurocognition in CNS Lymphoma. Neuro Oncol. 2021 Feb 24. Geng H, Tsang M, Subbaraj L, Cleveland J, Chen L, Lu M, Sharma J, Vigneron DB, Kurhanewicz J, LaFontaine M, Luks T, Barshop BA, Gangoiti J, Villanueva-Meyer JE, Rubenstein JL. PMID: 33625503.
      View in: PubMed   Mentions:    Fields:    
    4. Survival and Patient-Reported Outcomes of Older Adults with Primary Central Nervous System Lymphoma on Low-Dose Lenalidomide. Blood. 2020 Nov 5; 136(Supplement 1):21-22. Mazie Tsang, Joseph Cleveland, Miguel Carlos Cerejo, Huimin Geng, James L. Rubenstein. .
      View in: Publisher Site   Mentions:
    5. IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells. Nature. 2020 Nov 04. Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP, Thomas-Tikhonenko A, Farzan M, Jung JU, Weinstock DM, Manalis SR, Diamond MS, Vaidehi N, Müschen M. PMID: 33149299.
      View in: PubMed   Mentions:    Fields:    
    6. BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. Nat Genet. 2020 12; 52(12):1384-1396. Fan H, Lu J, Guo Y, Li D, Zhang ZM, Tsai YH, Pi WC, Ahn JH, Gong W, Xiang Y, Allison DF, Geng H, He S, Diao Y, Chen WY, Strahl BD, Cai L, Song J, Wang GG. PMID: 33139953.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. Human pediatric B-cell acute lymphoblastic leukemias can be classified as B-1 or B-2-like based on a minimal transcriptional signature. Exp Hematol. 2020 10; 90:65-71.e1. Fitch B, Roy R, Geng H, Montecino-Rodriguez E, Bengtsson H, Gaillard C, Hiam K, Casero D, Olshen AB, Dorshkind K, Kogan SC. PMID: 32946981.
      View in: PubMed   Mentions:    Fields:    
    8. Biokinetics and biotransformation of paralytic shellfish toxins in different tissues of Yesso scallops, Patinopecten yessoensis. Chemosphere. 2020 Dec; 261:128063. Liu Y, Kong FZ, Xun XG, Dai L, Geng HX, Hu XL, Yu RC, Bao ZM, Zhou MJ. PMID: 33113659.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    9. Signalling input from divergent pathways subverts B cell transformation. Nature. 2020 07; 583(7818):845-851. Chan LN, Murakami MA, Robinson ME, Caeser R, Sadras T, Lee J, Cosgun KN, Kume K, Khairnar V, Xiao G, Ahmed MA, Aghania E, Deb G, Hurtz C, Shojaee S, Hong C, Pölönen P, Nix MA, Chen Z, Chen CW, Chen J, Vogt A, Heinäniemi M, Lohi O, Wiita AP, Izraeli S, Geng H, Weinstock DM, Müschen M. PMID: 32699415.
      View in: PubMed   Mentions:    Fields:    
    10. Integrin a6 mediates the drug resistance of acute lymphoblastic B-cell leukemia. Blood. 2020 Jul 09; 136(2):210-223. Gang EJ, Kim HN, Hsieh YT, Ruan Y, Ogana HA, Lee S, Pham J, Geng H, Park E, Klemm L, Willman CL, Carroll WL, Mittelman SD, Orgel E, Oberley MJ, Parekh C, Abdel-Azim H, Bhojwani D, Wayne AS, De Arcangelis A, Georges-Labouesse E, Wayner E, Bonig H, Minasyan A, Ten Hoeve J, Graeber TG, Müschen M, Heisterkamp N, Kim YM. PMID: 32219444.
      View in: PubMed   Mentions: 1     Fields:    
    11. E2A-PBX1 functions as a coactivator for RUNX1 in acute lymphoblastic leukemia. Blood. 2020 Jul 02; 136(1):11-23. Pi WC, Wang J, Shimada M, Lin JW, Geng H, Lee YL, Lu R, Li D, Wang GG, Roeder RG, Chen WY. PMID: 32276273.
      View in: PubMed   Mentions: 1     Fields:    
    12. H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells. Leukemia. 2021 01; 35(1):90-106. Godfrey L, Crump NT, O'Byrne S, Lau IJ, Rice S, Harman JR, Jackson T, Elliott N, Buck G, Connor C, Thorne R, Knapp DJHF, Heidenreich O, Vyas P, Menendez P, Inglott S, Ancliff P, Geng H, Roberts I, Roy A, Milne TA. PMID: 32242051.
      View in: PubMed   Mentions: 1     Fields:    
    13. The lysine methyltransferase SMYD2 is required for normal lymphocyte development and survival of hematopoietic leukemias. Genes Immun. 2020 02; 21(2):119-130. Brown MA, Edwards MA, Alshiraihi I, Geng H, Dekker JD, Tucker HO. PMID: 32115575.
      View in: PubMed   Mentions: 2     Fields:    
    14. Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling. Blood. 2019 Nov 13; 134(Supplement_1):393-393. Jaewoong Lee, Kohei Kume, Zhengshan Chen, Gang Xiao, Kadriye Nehir Nehir Cosgun, Liting Chen, Lai N Chan, Lars Klemm, Chun-Wei David Chen, Ning Ma, Wing C. Chan, Stephen J Forman, Francesca Zammarchi, Patrick Van Berkel, Ari Melnick, Vu N Ngo, Huimin Geng, Selina M. Luger, Mark Litzow, Michael T McManus, Nagarajan Vaidehi, Elisabeth M. Paietta, Eric Meffre, David M. Weinstock, Markus Müschen. .
      View in: Publisher Site   Mentions:
    15. Paraoxonase 2 Enables Initiation of B-ALL By Subverting Metabolic Gatekeeper Functions. Blood. 2019 Nov 13; 134(Supplement_1):746-746. Lili Pan, Chao Hong, Gang Xiao, Huimin Geng, Shaoyuan Wang, Markus Müschen. .
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    16. Lgr5 Functions As a Critical Negative Regulator of Wnt/ß-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation. Blood. 2019 Nov 13; 134(Supplement_1):748-748. Kadriye Nehir Cosgun, Gauri Deb, Xin Yang, Gang Xiao, Teresa Sadras, Jaewoong Lee, Lai N Chan, Kohei Kume, Lu Yang, Huimin Geng, John Chan, Joo Y. Song, Hassan Jumaa, Andrew G. Polson, Hans Clevers, Markus Müschen. .
      View in: Publisher Site   Mentions:
    17. DNA methyltransferase inhibitors upregulate CD38 protein expression and enhance daratumumab efficacy in multiple myeloma. Leukemia. 2020 03; 34(3):938-941. Choudhry P, Mariano MC, Geng H, Martin TG, Wolf JL, Wong SW, Shah N, Wiita AP. PMID: 31595037.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    18. Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia. Genes Dev. 2019 09 01; 33(17-18):1265-1279. Hurtz C, Chan LN, Geng H, Ballabio E, Xiao G, Deb G, Khoury H, Chen CW, Armstrong SA, Chen J, Ernst P, Melnick A, Milne T, Müschen M. PMID: 31395741.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    19. Maintenance lenalidomide in primary CNS lymphoma. Ann Oncol. 2019 08 01; 30(8):1397-1398. Rubenstein JL, Geng H, Vu K, Mannis G, Formaker P, Hwang J, Munster PN, Damato B. PMID: 31046114.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Low-dose lenalidomide maintenance after induction therapy in older patients with primary central nervous system lymphoma. Br J Haematol. 2019 07; 186(1):180-183. Vu K, Mannis G, Hwang J, Geng H, Rubenstein JL. PMID: 30714128.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    21. Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis. Nat Immunol. 2019 01; 20(1):86-96. Hatzi K, Geng H, Doane AS, Meydan C, LaRiviere R, Cardenas M, Duy C, Shen H, Vidal MNC, Baslan T, Mohammad HP, Kruger RG, Shaknovich R, Haberman AM, Inghirami G, Lowe SW, Melnick AM. PMID: 30538335.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    22. Identification of IRF8 as a potent tumor suppressor in murine acute promyelocytic leukemia. Blood Adv. 2018 10 09; 2(19):2462-2466. Gaillard C, Surianarayanan S, Bentley T, Warr MR, Fitch B, Geng H, Passegué E, de Thé H, Kogan SC. PMID: 30266821.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    23. PRMT5 interacts with the BCL6 oncoprotein and is required for germinal center formation and lymphoma cell survival. Blood. 2018 11 08; 132(19):2026-2039. Lu X, Fernando TM, Lossos C, Yusufova N, Liu F, Fontán L, Durant M, Geng H, Melnick J, Luo Y, Vega F, Moy V, Inghirami G, Nimer S, Melnick AM, Lossos IS. PMID: 30082494.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    24. Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma. Blood Adv. 2018 07 10; 2(13):1595-1607. Rubenstein JL, Geng H, Fraser EJ, Formaker P, Chen L, Sharma J, Killea P, Choi K, Ventura J, Kurhanewicz J, Lowell C, Hwang J, Treseler P, Sneed PK, Li J, Wang X, Chen N, Gangoiti J, Munster PN, Damato B. PMID: 29986852.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    25. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell. 2018 04 05; 173(2):470-484.e18. Xiao G, Chan LN, Klemm L, Braas D, Chen Z, Geng H, Zhang QC, Aghajanirefah A, Cosgun KN, Sadras T, Lee J, Mirzapoiazova T, Salgia R, Ernst T, Hochhaus A, Jumaa H, Jiang X, Weinstock DM, Graeber TG, Müschen M. PMID: 29551267.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    26. CAMKs support development of acute myeloid leukemia. J Hematol Oncol. 2018 02 27; 11(1):30. Kang X, Cui C, Wang C, Wu G, Chen H, Lu Z, Chen X, Wang L, Huang J, Geng H, Zhao M, Chen Z, Müschen M, Wang HY, Zhang CC. PMID: 29482582.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    27. Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies. Proc Natl Acad Sci U S A. 2018 03 13; 115(11):2836-2841. Pollock SB, Hu A, Mou Y, Martinko AJ, Julien O, Hornsby M, Ploder L, Adams JJ, Geng H, Müschen M, Sidhu SS, Moffat J, Wells JA. PMID: 29476010.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    28. Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia. Nat Commun. 2017 12 19; 8(1):2127. Stieglitz E, Mazor T, Olshen AB, Geng H, Gelston LC, Akutagawa J, Lipka DB, Plass C, Flotho C, Chehab FF, Braun BS, Costello JF, Loh ML. PMID: 29259179.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCellsCTClinical Trials
    29. BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells. Cancer Discov. 2017 05; 7(5):506-521. Valls E, Lobry C, Geng H, Wang L, Cardenas M, Rivas M, Cerchietti L, Oh P, Yang SN, Oswald E, Graham CW, Jiang Y, Hatzi K, Agirre X, Perkey E, Li Z, Tam W, Bhatt K, Leonard JP, Zweidler-McKay PA, Maillard I, Elemento O, Ci W, Aifantis I, Melnick A. PMID: 28232365.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    30. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017 02 23; 542(7642):479-483. Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. PMID: 28192788.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    31. Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL. J Exp Med. 2017 03 06; 214(3):793-814. Schjerven H, Ayongaba EF, Aghajanirefah A, McLaughlin J, Cheng D, Geng H, Boyd JR, Eggesbø LM, Lindeman I, Heath JL, Park E, Witte ON, Smale ST, Frietze S, Müschen M. PMID: 28190001.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    32. MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia. Cell Rep. 2017 01 10; 18(2):482-495. Kerry J, Godfrey L, Repapi E, Tapia M, Blackledge NP, Ma H, Ballabio E, O'Byrne S, Ponthan F, Heidenreich O, Roy A, Roberts I, Konopleva M, Klose RJ, Geng H, Milne TA. PMID: 28076791.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    33. MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation. Exp Hematol. 2017 03; 47:64-75. Godfrey L, Kerry J, Thorne R, Repapi E, Davies JO, Tapia M, Ballabio E, Hughes JR, Geng H, Konopleva M, Milne TA. PMID: 27856324.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    34. CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas. Cancer Discov. 2017 01; 7(1):38-53. Jiang Y, Ortega-Molina A, Geng H, Ying HY, Hatzi K, Parsa S, McNally D, Wang L, Doane AS, Agirre X, Teater M, Meydan C, Li Z, Poloway D, Wang S, Ennishi D, Scott DW, Stengel KR, Kranz JE, Holson E, Sharma S, Young JW, Chu CS, Roeder RG, Shaknovich R, Hiebert SW, Gascoyne RD, Tam W, Elemento O, Wendel HG, Melnick AM. PMID: 27733359.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    35. Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma. J Clin Invest. 2016 09 01; 126(9):3351-62. Cardenas MG, Yu W, Beguelin W, Teater MR, Geng H, Goldstein RL, Oswald E, Hatzi K, Yang SN, Cohen J, Shaknovich R, Vanommeslaeghe K, Cheng H, Liang D, Cho HJ, Abbott J, Tam W, Du W, Leonard JP, Elemento O, Cerchietti L, Cierpicki T, Xue F, MacKerell AD, Melnick AM. PMID: 27482887.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    36. PTEN opposes negative selection and enables oncogenic transformation of pre-B cells. Nat Med. 2016 Apr; 22(4):379-87. Shojaee S, Chan LN, Buchner M, Cazzaniga V, Cosgun KN, Geng H, Qiu YH, von Minden MD, Ernst T, Hochhaus A, Cazzaniga G, Melnick A, Kornblau SM, Graeber TG, Wu H, Jumaa H, Müschen M. PMID: 26974310.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    37. Deregulated expression of the HSP40 family members Auxilin-1 and -2 is indicative of proteostasis imbalance and predicts patient outcome in Ph(+) leukemia. Exp Hematol Oncol. 2015; 5:5. Vieri M, Geng H, Patterson JB, Panse J, Wilop S, Samali A, Chevet E, Kharabi Masouleh B. PMID: 26862466.
      View in: PubMed   Mentions:
    38. MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199. Cell Rep. 2015 Dec 29; 13(12):2715-27. Benito JM, Godfrey L, Kojima K, Hogdal L, Wunderlich M, Geng H, Marzo I, Harutyunyan KG, Golfman L, North P, Kerry J, Ballabio E, Chonghaile TN, Gonzalo O, Qiu Y, Jeremias I, Debose L, O'Brien E, Ma H, Zhou P, Jacamo R, Park E, Coombes KR, Zhang N, Thomas DA, O'Brien S, Kantarjian HM, Leverson JD, Kornblau SM, Andreeff M, Müschen M, Zweidler-McKay PA, Mulloy JC, Letai A, Milne TA, Konopleva M. PMID: 26711339.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    39. Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia. Cancer Cell. 2015 Jul 13; 28(1):114-28. Shojaee S, Caeser R, Buchner M, Park E, Swaminathan S, Hurtz C, Geng H, Chan LN, Klemm L, Hofmann WK, Qiu YH, Zhang N, Coombes KR, Paietta E, Molkentin J, Koeffler HP, Willman CL, Hunger SP, Melnick A, Kornblau SM, Müschen M. PMID: 26073130.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    40. Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia. Nat Immunol. 2015 Jul; 16(7):766-774. Swaminathan S, Klemm L, Park E, Papaemmanuil E, Ford A, Kweon SM, Trageser D, Hasselfeld B, Henke N, Mooster J, Geng H, Schwarz K, Kogan SC, Casellas R, Schatz DG, Lieber MR, Greaves MF, Müschen M. PMID: 25985233.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    41. TET1 is a tumor suppressor of hematopoietic malignancy. Nat Immunol. 2015 Jun; 16(6):653-62. Cimmino L, Dawlaty MM, Ndiaye-Lobry D, Yap YS, Bakogianni S, Yu Y, Bhattacharyya S, Shaknovich R, Geng H, Lobry C, Mullenders J, King B, Trimarchi T, Aranda-Orgilles B, Liu C, Shen S, Verma AK, Jaenisch R, Aifantis I. PMID: 25867473.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    42. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015 May 21; 521(7552):357-61. Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. PMID: 25799995.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    43. Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia. Nat Commun. 2015 Mar 10; 6:6471. Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M. PMID: 25753524.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    44. Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia. Cancer Cell. 2015 Mar 09; 27(3):409-25. Geng H, Hurtz C, Lenz KB, Chen Z, Baumjohann D, Thompson S, Goloviznina NA, Chen WY, Huan J, LaTocha D, Ballabio E, Xiao G, Lee JW, Deucher A, Qi Z, Park E, Huang C, Nahar R, Kweon SM, Shojaee S, Chan LN, Yu J, Kornblau SM, Bijl JJ, Ye BH, Ansel KM, Paietta E, Melnick A, Hunger SP, Kurre P, Tyner JW, Loh ML, Roeder RG, Druker BJ, Burger JA, Milne TA, Chang BH, Müschen M. PMID: 25759025.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    45. IL10 receptor is a novel therapeutic target in DLBCLs. Leukemia. 2015 Aug; 29(8):1684-94. Béguelin W, Sawh S, Chambwe N, Chan FC, Jiang Y, Choo JW, Scott DW, Chalmers A, Geng H, Tsikitas L, Tam W, Bhagat G, Gascoyne RD, Shaknovich R. PMID: 25733167.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    46. Global promoter methylation analysis reveals novel candidate tumor suppressor genes in natural killer cell lymphoma. Clin Cancer Res. 2015 Apr 01; 21(7):1699-711. Küçük C, Hu X, Jiang B, Klinkebiel D, Geng H, Gong Q, Bouska A, Iqbal J, Gaulard P, McKeithan TW, Chan WC. PMID: 25614448.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    47. Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):E2219-28. Kharabi Masouleh B, Geng H, Hurtz C, Chan LN, Logan AC, Chang MS, Huang C, Swaminathan S, Sun H, Paietta E, Melnick AM, Koeffler P, Müschen M. PMID: 24821775.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    48. Variability in DNA methylation defines novel epigenetic subgroups of DLBCL associated with different clinical outcomes. Blood. 2014 Mar 13; 123(11):1699-708. Chambwe N, Kormaksson M, Geng H, De S, Michor F, Johnson NA, Morin RD, Scott DW, Godley LA, Gascoyne RD, Melnick A, Campagne F, Shaknovich R. PMID: 24385541.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    49. Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation. Blood. 2014 Feb 13; 123(7):1012-20. Huang C, Geng H, Boss I, Wang L, Melnick A. PMID: 24277074.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    50. A TAF4 coactivator function for E proteins that involves enhanced TFIID binding. Genes Dev. 2013 Jul 15; 27(14):1596-609. Chen WY, Zhang J, Geng H, Du Z, Nakadai T, Roeder RG. PMID: 23873942.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    51. BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint. Nat Med. 2013 Aug; 19(8):1014-22. Swaminathan S, Huang C, Geng H, Chen Z, Harvey R, Kang H, Ng C, Titz B, Hurtz C, Sadiyah MF, Nowak D, Thoennissen GB, Rand V, Graeber TG, Koeffler HP, Carroll WL, Willman CL, Hall AG, Igarashi K, Melnick A, Müschen M. PMID: 23852341.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    52. Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile. Blood. 2013 Aug 15; 122(7):1293-304. Cramer-Morales K, Nieborowska-Skorska M, Scheibner K, Padget M, Irvine DA, Sliwinski T, Haas K, Lee J, Geng H, Roy D, Slupianek A, Rassool FV, Wasik MA, Childers W, Copland M, Müschen M, Civin CI, Skorski T. PMID: 23836560.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    53. Imatinib disrupts lymphoma angiogenesis by targeting vascular pericytes. Blood. 2013 Jun 27; 121(26):5192-202. Ruan J, Luo M, Wang C, Fan L, Yang SN, Cardenas M, Geng H, Leonard JP, Melnick A, Cerchietti L, Hajjar KA. PMID: 23632889.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
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    55. Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy. Blood. 2013 Mar 07; 121(10):1814-8. Hsieh YT, Gang EJ, Geng H, Park E, Huantes S, Chudziak D, Dauber K, Schaefer P, Scharman C, Shimada H, Shojaee S, Klemm L, Parameswaran R, Loh M, Kang ES, Koo HH, Hofmann WK, Andrade J, Crooks GM, Willman CL, Müschen M, Papayannopoulou T, Heisterkamp N, Bönig H, Kim YM. PMID: 23319569.
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    56. Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity. PLoS Genet. 2013; 9(1):e1003137. De S, Shaknovich R, Riester M, Elemento O, Geng H, Kormaksson M, Jiang Y, Woolcock B, Johnson N, Polo JM, Cerchietti L, Gascoyne RD, Melnick A, Michor F. PMID: 23326238.
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    57. SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia. Blood. 2013 Jan 03; 121(1):148-55. Ramezani-Rad P, Geng H, Hurtz C, Chan LN, Chen Z, Jumaa H, Melnick A, Paietta E, Carroll WL, Willman CL, Lefebvre V, Müschen M. PMID: 23152540.
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    58. Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia. Cancer Discov. 2012 Nov; 2(11):1004-23. Geng H, Brennan S, Milne TA, Chen WY, Li Y, Hurtz C, Kweon SM, Zickl L, Shojaee S, Neuberg D, Huang C, Biswas D, Xin Y, Racevskis J, Ketterling RP, Luger SM, Lazarus H, Tallman MS, Rowe JM, Litzow MR, Guzman ML, Allis CD, Roeder RG, Müschen M, Paietta E, Elemento O, Melnick AM. PMID: 23107779.
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    59. Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC. Blood. 2011 Oct 13; 118(15):4174-8. Nahar R, Ramezani-Rad P, Mossner M, Duy C, Cerchietti L, Geng H, Dovat S, Jumaa H, Ye BH, Melnick A, Müschen M. PMID: 21856866.
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    60. BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature. 2011 May 19; 473(7347):384-8. Duy C, Hurtz C, Shojaee S, Cerchietti L, Geng H, Swaminathan S, Klemm L, Kweon SM, Nahar R, Braig M, Park E, Kim YM, Hofmann WK, Herzog S, Jumaa H, Koeffler HP, Yu JJ, Heisterkamp N, Graeber TG, Wu H, Ye BH, Melnick A, Müschen M. PMID: 21593872.
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    61. Virtual CGH: an integrative approach to predict genetic abnormalities from gene expression microarray data applied in lymphoma. BMC Med Genomics. 2011 Apr 12; 4:32. Geng H, Iqbal J, Chan WC, Ali HH. PMID: 21486456.
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    62. EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis. Blood. 2010 Dec 09; 116(24):5247-55. Velichutina I, Shaknovich R, Geng H, Johnson NA, Gascoyne RD, Melnick AM, Elemento O. PMID: 20736451.
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    63. DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma. Blood. 2010 Nov 18; 116(20):e81-9. Shaknovich R, Geng H, Johnson NA, Tsikitas L, Cerchietti L, Greally JM, Gascoyne RD, Elemento O, Melnick A. PMID: 20610814.
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    64. Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma. Blood. 2010 Feb 04; 115(5):1026-36. Iqbal J, Weisenburger DD, Greiner TC, Vose JM, McKeithan T, Kucuk C, Geng H, Deffenbacher K, Smith L, Dybkaer K, Nakamura S, Seto M, Delabie J, Berger F, Loong F, Au WY, Ko YH, Sng I, Armitage JO, Chan WC. PMID: 19965671.
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    65. A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy. Clin Cancer Res. 2009 Sep 01; 15(17):5494-502. Choi WW, Weisenburger DD, Greiner TC, Piris MA, Banham AH, Delabie J, Braziel RM, Geng H, Iqbal J, Lenz G, Vose JM, Hans CP, Fu K, Smith LM, Li M, Liu Z, Gascoyne RD, Rosenwald A, Ott G, Rimsza LM, Campo E, Jaffe ES, Jaye DL, Staudt LM, Chan WC. PMID: 19706817.
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    66. Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies. Leukemia. 2009 Jun; 23(6):1139-51. Iqbal J, Kucuk C, Deleeuw RJ, Srivastava G, Tam W, Geng H, Klinkebiel D, Christman JK, Patel K, Cao K, Shen L, Dybkaer K, Tsui IF, Ali H, Shimizu N, Au WY, Lam WL, Chan WC. PMID: 19194464.
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    67. Genetic Abnormalities Involved in the Development and Progression of Follicular Lymphoma. Blood. 2008 Nov 16; 112(11):2049-2049. Karen E Deffenbacher, George Wright, Javeed Iqbal, Huimin Geng, Derville O’Shea, T. Andrew Lister, Jude Fitzgibbon, Kai Fu, Zhongfeng Liu, Dennis Weisenburger, Timothy C. Greiner, Randy D. Gascoyne, Andreas Rosenwald, Elias Campo, Lisa M. Rimsza, Jan Delabie, Elaine S Jaffe, Louis M. Staudt, Wing C. Chan. .
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    69. A Hidden Markov Model approach to predicting yeast gene function from sequential gene expression data. Int J Bioinform Res Appl. 2008; 4(3):263-73. Deng X, Geng H, Ali HH. PMID: 18640903.
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    70. Message Passing Clustering (MPC): a knowledge-based framework for clustering under biological constraints. Int J Data Min Bioinform. 2008; 2(2):95-120. Geng H, Deng X, Ali HH. PMID: 18767349.
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    71. A Hidden Markov Model Approach for Prediction of Genomic Alterations from Gene Expression Profiling. In Ion Mandoiu, Raj Sunderraman and Alexander Zelikovsky (Eds.) Lecture Notes in Computer Science (LNCS). 2008; 4983:414-426. Springer, Heidelberg. Geng H, Ali HH, Chan WC.
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    73. Cross-platform analysis of cancer biomarkers: a Bayesian network approach to incorporating mass spectrometry and microarray data. Cancer Inform. 2007 Apr 29; 3:183-202. Deng X, Geng H, Ali HH. PMID: 19455243.
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    75. Dynamics of asynchronous random Boolean networks with asynchrony generated by stochastic processes. Biosystems. 2007 Mar; 88(1-2):16-34. Deng X, Geng H, Matache MT. PMID: 16870321.
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    77. Molecular and Morphological Analyses of the Sportive Lemurs (Family Megaladapidae: Genus Lepilemur) Reveals 11 Previously Unrecognized Species. Special Publications Museum of Texas Tech University. 2006; 49(SP):1-49. Louis EE, Jr., Engberg SE, Lei R, Geng H, Sommer JA, Randriamampionona R, Randriamanana JC, Zaonarivelo JR, Andriantompohavana R, Randria G, Ramaromilanto B, Rakotoarisoa G, Rooney A, Brenneman RA.
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    79. Learning yeast gene functions from heterogeneous sources of data using hybrid weighted Bayesian networks. Proc IEEE Comput Syst Bioinform Conf. 2005; 25-34. Deng X, Geng H, Ali H. PMID: 16447959.
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    80. Mining Gene Microarray Data with Adaptive Feature Scaling. Proceedings of 4th IEEE International Conference on Electro Information Technology (EIT’05). 2005; 1-6. Geng H, Deng X, Ali HH.
    81. On Clustering Biological Data Using Unsupervised and Semi-supervised Message Passing. Proceedings of IEEE 5th Symposium on Bioinformatics and Bioengineering (BIBE). 2005; 294-298. Geng H, Deng X, Bastola DR, Ali HH.