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Peripheral T-cell lymphomas expressing CD30 and CD15 expand the spectrum of anaplastic large cell lymphoma, ALK-negative. Br J Haematol. 2024 Apr 12.
Ganapathi KA, Nicolae A, Egan C, Geng H, Xi L, Pack SD, McFadden JR, Raffeld M, Jaffe ES, Pittaluga S. PMID: 38613165.
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PubMed Mentions:
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Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells. bioRxiv. 2024 Feb 28.
Kasap C, Izgutdina A, Patiño-Escobar B, Kang A, Chilakapati N, Akagi N, Johnson H, Rashid T, Werner J, Barpanda A, Geng H, Lin YT, Rampersaud S, Gil-Alós D, Sobh A, Dupéré-Richer D, Wicaksono G, Kawehi Kelii KM, Dalal R, Ramos E, Vijayanarayanan A, Salangsang F, Phojanakong P, Serrano JAC, Zakraoui O, Tariq I, Steri V, Shanmugam M, Boise LH, Kortemme T, Stieglitz E, Licht JD, Karlon WJ, Barwick BG, Wiita AP. PMID: 38463958; PMCID: PMC10925123.
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PubMed Mentions:
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CD46-targeted theranostics for Positron Emission Tomography and 225Ac-Radiopharmaceutical Therapy of Multiple Myeloma. Clin Cancer Res. 2023 Dec 18.
Wadhwa A, Wang S, Patiño-Escobar B, Bidkar AP, Bobba KN, Chan E, Meher N, Bidlingmaier S, Su Y, Dhrona S, Geng H, Sarin V, VanBrocklin HF, Wilson DM, He J, Zhang L, Steri V, Wong SW, Martin TG, Seo Y, Liu B, Wiita AP, Flavell RR. PMID: 38109209.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Local manufacturing processes contribute to variability in human mesenchymal stromal cell expansion while growth media supplements contribute to variability in gene expression and cell function: a Biomedical Excellence for Safer Transfusion (BEST) collaborative study. Cytotherapy. 2023 Dec 02.
Shaz BH, Schäfer R, Fontaine MJ, Norris PJ, McKenna DH, Jin P, Reems JA, Stroncek D, Tanashi M, Marks D, Geng H, Pati S, for Biomedical Excellence for Safer Transfusion (BEST). PMID: 38043052.
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MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia. Nat Commun. 2023 08 25; 14(1):5208.
Crump NT, Smith AL, Godfrey L, Dopico-Fernandez AM, Denny N, Harman JR, Hamley JC, Jackson NE, Chahrour C, Riva S, Rice S, Kim J, Basrur V, Fermin D, Elenitoba-Johnson K, Roeder RG, Allis CD, Roberts I, Roy A, Geng H, Davies JOJ, Milne TA. PMID: 37626123; PMCID: PMC10457349.
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Translation:
HumansCells
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Artemis inhibition as a therapeutic strategy for acute lymphoblastic leukemia. Front Cell Dev Biol. 2023; 11:1134121.
Ogana HA, Hurwitz S, Hsieh CL, Geng H, Müschen M, Bhojwani D, Wolf MA, Larocque J, Lieber MR, Kim YM. PMID: 37082620; PMCID: PMC10111164.
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PubMed Mentions:
1
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Dynamic phosphatase-recruitment controls B-cell selection and oncogenic signaling. bioRxiv. 2023 Mar 15.
Lee J, Robinson ME, Sun R, Kume K, Ma N, Cosgun KN, Chan LN, Leveille E, Geng H, Vykunta VS, Shy BR, Marson A, Katz S, Chen J, Paietta E, Meffre E, Vaidehi N, Müschen M. PMID: 36993276; PMCID: PMC10054997.
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Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling. Elife. 2023 03 13; 12.
Feng X, Sun R, Lee M, Chen X, Guo S, Geng H, Müschen M, Choi J, Pereira JP. PMID: 36912771; PMCID: PMC10042536.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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BTG1 mutation yields supercompetitive B cells primed for malignant transformation. Science. 2023 01 20; 379(6629):eabj7412.
Mlynarczyk C, Teater M, Pae J, Chin CR, Wang L, Arulraj T, Barisic D, Papin A, Hoehn KB, Kots E, Ersching J, Bandyopadhyay A, Barin E, Poh HX, Evans CM, Chadburn A, Chen Z, Shen H, Isles HM, Pelzer B, Tsialta I, Doane AS, Geng H, Rehman MH, Melnick J, Morgan W, Nguyen DTT, Elemento O, Kharas MG, Jaffrey SR, Scott DW, Khelashvili G, Meyer-Hermann M, Victora GD, Melnick A. PMID: 36656933; PMCID: PMC10515739.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Lyophilized plasma resuscitation downregulates inflammatory gene expression in a mouse model of sepsis. J Trauma Acute Care Surg. 2022 08 01; 93(2S Suppl 1):S119-S127.
Barry M, Wu F, Pati S, Chipman A, Geng H, Kozar R. PMID: 35881828.
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Translation:
Animals
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Overcoming Microenvironment-Mediated Chemoprotection through Stromal Galectin-3 Inhibition in Acute Lymphoblastic Leukemia. Int J Mol Sci. 2021 Nov 10; 22(22).
Tarighat SS, Fei F, Joo EJ, Abdel-Azim H, Yang L, Geng H, Bum-Erdene K, Grice ID, von Itzstein M, Blanchard H, Heisterkamp N. PMID: 34830047; PMCID: PMC8624256.
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PubMed Mentions:
5 Fields:
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HumansAnimalsCells
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Tumor metabolism and neurocognition in CNS lymphoma. Neuro Oncol. 2021 10 01; 23(10):1668-1679.
Geng H, Tsang M, Subbaraj L, Cleveland J, Chen L, Lu M, Sharma J, Vigneron DB, Kurhanewicz J, LaFontaine M, Luks T, Barshop BA, Gangoiti J, Villanueva-Meyer JE, Rubenstein JL. PMID: 33625503; PMCID: PMC8485453.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth. Nat Commun. 2021 09 09; 12(1):5337.
Chan TY, Egbert CM, Maxson JE, Siddiqui A, Larsen LJ, Kohler K, Balasooriya ER, Pennington KL, Tsang TM, Frey M, Soderblom EJ, Geng H, Müschen M, Forostyan TV, Free S, Mercenne G, Banks CJ, Valdoz J, Whatcott CJ, Foulks JM, Bearss DJ, O'Hare T, Huang DCS, Christensen KA, Moody J, Warner SL, Tyner JW, Andersen JL. PMID: 34504101; PMCID: PMC8429728.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Absence of Influenza and RSV Activity in the San
Francisco Bay Area during the COVID-19 Pandemic, 2020-2021. J Adv Virol Res. 2021; 1(1):103.
Drew WL, Miller S, Geng H, Ingebrigtsen D, Suslow LM and Suslow PS. View Publication.
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Surface Proteomics Reveals CD72 as a Target for In Vitro-Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL. Cancer Discov. 2021 08; 11(8):2032-2049.
Nix MA, Mandal K, Geng H, Paranjape N, Lin YT, Rivera JM, Marcoulis M, White KL, Whitman JD, Bapat SP, Parker KR, Ramirez J, Deucher A, Phojanokong P, Steri V, Fattahi F, Hann BC, Satpathy AT, Manglik A, Stieglitz E, Wiita AP. PMID: 33727310; PMCID: PMC8338785.
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PubMed Mentions:
21 Fields:
Translation:
Humans
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PON2 subverts metabolic gatekeeper functions in B cells to promote leukemogenesis. Proc Natl Acad Sci U S A. 2021 02 16; 118(7).
Pan L, Hong C, Chan LN, Xiao G, Malvi P, Robinson ME, Geng H, Reddy ST, Lee J, Khairnar V, Cosgun KN, Xu L, Kume K, Sadras T, Wang S, Wajapeyee N, Müschen M. PMID: 33531346; PMCID: PMC7896313.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells. Nature. 2020 12; 588(7838):491-497.
Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP, Thomas-Tikhonenko A, Farzan M, Jung JU, Weinstock DM, Manalis SR, Diamond MS, Vaidehi N, Müschen M. PMID: 33149299; PMCID: PMC8087162.
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PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. Nat Genet. 2020 12; 52(12):1384-1396.
Fan H, Lu J, Guo Y, Li D, Zhang ZM, Tsai YH, Pi WC, Ahn JH, Gong W, Xiang Y, Allison DF, Geng H, He S, Diao Y, Chen WY, Strahl BD, Cai L, Song J, Wang GG. PMID: 33139953; PMCID: PMC8330957.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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Human pediatric B-cell acute lymphoblastic leukemias can be classified as B-1 or B-2-like based on a minimal transcriptional signature. Exp Hematol. 2020 10; 90:65-71.e1.
Fitch B, Roy R, Geng H, Montecino-Rodriguez E, Bengtsson H, Gaillard C, Hiam K, Casero D, Olshen AB, Dorshkind K, Kogan SC. PMID: 32946981; PMCID: PMC7606616.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Signalling input from divergent pathways subverts B cell transformation. Nature. 2020 07; 583(7818):845-851.
Chan LN, Murakami MA, Robinson ME, Caeser R, Sadras T, Lee J, Cosgun KN, Kume K, Khairnar V, Xiao G, Ahmed MA, Aghania E, Deb G, Hurtz C, Shojaee S, Hong C, Pölönen P, Nix MA, Chen Z, Chen CW, Chen J, Vogt A, Heinäniemi M, Lohi O, Wiita AP, Izraeli S, Geng H, Weinstock DM, Müschen M. PMID: 32699415; PMCID: PMC7394729.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia. Blood. 2020 07 09; 136(2):210-223.
Gang EJ, Kim HN, Hsieh YT, Ruan Y, Ogana HA, Lee S, Pham J, Geng H, Park E, Klemm L, Willman CL, Carroll WL, Mittelman SD, Orgel E, Oberley MJ, Parekh C, Abdel-Azim H, Bhojwani D, Wayne AS, De Arcangelis A, Georges-Labouesse E, Wayner E, Bonig H, Minasyan A, Ten Hoeve J, Graeber TG, Müschen M, Heisterkamp N, Kim YM. PMID: 32219444; PMCID: PMC7357190.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimals
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E2A-PBX1 functions as a coactivator for RUNX1 in acute lymphoblastic leukemia. Blood. 2020 07 02; 136(1):11-23.
Pi WC, Wang J, Shimada M, Lin JW, Geng H, Lee YL, Lu R, Li D, Wang GG, Roeder RG, Chen WY. PMID: 32276273; PMCID: PMC7332894.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells. Leukemia. 2021 01; 35(1):90-106.
Godfrey L, Crump NT, O'Byrne S, Lau IJ, Rice S, Harman JR, Jackson T, Elliott N, Buck G, Connor C, Thorne R, Knapp DJHF, Heidenreich O, Vyas P, Menendez P, Inglott S, Ancliff P, Geng H, Roberts I, Roy A, Milne TA. PMID: 32242051; PMCID: PMC7787973.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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The lysine methyltransferase SMYD2 is required for normal lymphocyte development and survival of hematopoietic leukemias. Genes Immun. 2020 02; 21(2):119-130.
Brown MA, Edwards MA, Alshiraihi I, Geng H, Dekker JD, Tucker HO. PMID: 32115575; PMCID: PMC7183909.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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DNA methyltransferase inhibitors upregulate CD38 protein expression and enhance daratumumab efficacy in multiple myeloma. Leukemia. 2020 03; 34(3):938-941.
Choudhry P, Mariano MC, Geng H, Martin TG, Wolf JL, Wong SW, Shah N, Wiita AP. PMID: 31595037; PMCID: PMC7214267.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia. Genes Dev. 2019 09 01; 33(17-18):1265-1279.
Hurtz C, Chan LN, Geng H, Ballabio E, Xiao G, Deb G, Khoury H, Chen CW, Armstrong SA, Chen J, Ernst P, Melnick A, Milne T, Müschen M. PMID: 31395741; PMCID: PMC6719625.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Maintenance lenalidomide in primary CNS lymphoma. Ann Oncol. 2019 08 01; 30(8):1397-1398.
Rubenstein JL, Geng H, Vu K, Mannis G, Formaker P, Hwang J, Munster PN, Damato B. PMID: 31046114; PMCID: PMC8887569.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Low-dose lenalidomide maintenance after induction therapy in older patients with primary central nervous system lymphoma. Br J Haematol. 2019 07; 186(1):180-183.
Vu K, Mannis G, Hwang J, Geng H, Rubenstein JL. PMID: 30714128; PMCID: PMC8776513.
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PubMed Mentions:
15 Fields:
Translation:
Humans
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Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis. Nat Immunol. 2019 01; 20(1):86-96.
Hatzi K, Geng H, Doane AS, Meydan C, LaRiviere R, Cardenas M, Duy C, Shen H, Vidal MNC, Baslan T, Mohammad HP, Kruger RG, Shaknovich R, Haberman AM, Inghirami G, Lowe SW, Melnick AM. PMID: 30538335; PMCID: PMC6294324.
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PubMed Mentions:
45 Fields:
Translation:
AnimalsCells
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Identification of IRF8 as a potent tumor suppressor in murine acute promyelocytic leukemia. Blood Adv. 2018 10 09; 2(19):2462-2466.
Gaillard C, Surianarayanan S, Bentley T, Warr MR, Fitch B, Geng H, Passegué E, de Thé H, Kogan SC. PMID: 30266821; PMCID: PMC6177650.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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PRMT5 interacts with the BCL6 oncoprotein and is required for germinal center formation and lymphoma cell survival. Blood. 2018 11 08; 132(19):2026-2039.
Lu X, Fernando TM, Lossos C, Yusufova N, Liu F, Fontán L, Durant M, Geng H, Melnick J, Luo Y, Vega F, Moy V, Inghirami G, Nimer S, Melnick AM, Lossos IS. PMID: 30082494; PMCID: PMC6236466.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma. Blood Adv. 2018 07 10; 2(13):1595-1607.
Rubenstein JL, Geng H, Fraser EJ, Formaker P, Chen L, Sharma J, Killea P, Choi K, Ventura J, Kurhanewicz J, Lowell C, Hwang J, Treseler P, Sneed PK, Li J, Wang X, Chen N, Gangoiti J, Munster PN, Damato B. PMID: 29986852; PMCID: PMC6039666.
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PubMed Mentions:
60 Fields:
Translation:
HumansCTClinical Trials
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Abstract 4975: Tumor metabolism and cognitive dysfunction in CNS lymphoma. Cancer Research. 2018 Jul 1; 78(13_Supplement):4975-4975.
Subbaraj SL, Geng GH, Sharma SJ, LaFontaine LM, Rubenstein RJ. .
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Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2018 06; 558(7711):E5.
Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. PMID: 29849140.
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B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell. 2018 04 05; 173(2):470-484.e18.
Xiao G, Chan LN, Klemm L, Braas D, Chen Z, Geng H, Zhang QC, Aghajanirefah A, Cosgun KN, Sadras T, Lee J, Mirzapoiazova T, Salgia R, Ernst T, Hochhaus A, Jumaa H, Jiang X, Weinstock DM, Graeber TG, Müschen M. PMID: 29551267; PMCID: PMC6284818.
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PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
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CAMKs support development of acute myeloid leukemia. J Hematol Oncol. 2018 02 27; 11(1):30.
Kang X, Cui C, Wang C, Wu G, Chen H, Lu Z, Chen X, Wang L, Huang J, Geng H, Zhao M, Chen Z, Müschen M, Wang HY, Zhang CC. PMID: 29482582; PMCID: PMC5828341.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies. Proc Natl Acad Sci U S A. 2018 03 13; 115(11):2836-2841.
Pollock SB, Hu A, Mou Y, Martinko AJ, Julien O, Hornsby M, Ploder L, Adams JJ, Geng H, Müschen M, Sidhu SS, Moffat J, Wells JA. PMID: 29476010; PMCID: PMC5856557.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia. Nat Commun. 2017 12 19; 8(1):2127.
Stieglitz E, Mazor T, Olshen AB, Geng H, Gelston LC, Akutagawa J, Lipka DB, Plass C, Flotho C, Chehab FF, Braun BS, Costello JF, Loh ML. PMID: 29259179; PMCID: PMC5736624.
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PubMed Mentions:
32 Fields:
Translation:
HumansCellsCTClinical Trials
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BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells. Cancer Discov. 2017 05; 7(5):506-521.
Valls E, Lobry C, Geng H, Wang L, Cardenas M, Rivas M, Cerchietti L, Oh P, Yang SN, Oswald E, Graham CW, Jiang Y, Hatzi K, Agirre X, Perkey E, Li Z, Tam W, Bhatt K, Leonard JP, Zweidler-McKay PA, Maillard I, Elemento O, Ci W, Aifantis I, Melnick A. PMID: 28232365; PMCID: PMC5413414.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017 02 23; 542(7642):479-483.
Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. PMID: 28192788; PMCID: PMC5621518.
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PubMed Mentions:
119 Fields:
Translation:
HumansAnimalsCells
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Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL. J Exp Med. 2017 03 06; 214(3):793-814.
Schjerven H, Ayongaba EF, Aghajanirefah A, McLaughlin J, Cheng D, Geng H, Boyd JR, Eggesbø LM, Lindeman I, Heath JL, Park E, Witte ON, Smale ST, Frietze S, Müschen M. PMID: 28190001; PMCID: PMC5339667.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia. Cell Rep. 2017 01 10; 18(2):482-495.
Kerry J, Godfrey L, Repapi E, Tapia M, Blackledge NP, Ma H, Ballabio E, O'Byrne S, Ponthan F, Heidenreich O, Roy A, Roberts I, Konopleva M, Klose RJ, Geng H, Milne TA. PMID: 28076791; PMCID: PMC5263239.
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PubMed Mentions:
40 Fields:
Translation:
HumansCells
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MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation. Exp Hematol. 2017 03; 47:64-75.
Godfrey L, Kerry J, Thorne R, Repapi E, Davies JO, Tapia M, Ballabio E, Hughes JR, Geng H, Konopleva M, Milne TA. PMID: 27856324; PMCID: PMC5333536.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas. Cancer Discov. 2017 01; 7(1):38-53.
Jiang Y, Ortega-Molina A, Geng H, Ying HY, Hatzi K, Parsa S, McNally D, Wang L, Doane AS, Agirre X, Teater M, Meydan C, Li Z, Poloway D, Wang S, Ennishi D, Scott DW, Stengel KR, Kranz JE, Holson E, Sharma S, Young JW, Chu CS, Roeder RG, Shaknovich R, Hiebert SW, Gascoyne RD, Tam W, Elemento O, Wendel HG, Melnick AM. PMID: 27733359; PMCID: PMC5300005.
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PubMed Mentions:
117 Fields:
Translation:
HumansAnimalsCells
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Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma. J Clin Invest. 2016 09 01; 126(9):3351-62.
Cardenas MG, Yu W, Beguelin W, Teater MR, Geng H, Goldstein RL, Oswald E, Hatzi K, Yang SN, Cohen J, Shaknovich R, Vanommeslaeghe K, Cheng H, Liang D, Cho HJ, Abbott J, Tam W, Du W, Leonard JP, Elemento O, Cerchietti L, Cierpicki T, Xue F, MacKerell AD, Melnick AM. PMID: 27482887; PMCID: PMC5004937.
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PubMed Mentions:
81 Fields:
Translation:
HumansAnimalsCells
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PTEN opposes negative selection and enables oncogenic transformation of pre-B cells. Nat Med. 2016 Apr; 22(4):379-87.
Shojaee S, Chan LN, Buchner M, Cazzaniga V, Cosgun KN, Geng H, Qiu YH, von Minden MD, Ernst T, Hochhaus A, Cazzaniga G, Melnick A, Kornblau SM, Graeber TG, Wu H, Jumaa H, Müschen M. PMID: 26974310; PMCID: PMC5178869.
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PubMed Mentions:
54 Fields:
Translation:
HumansAnimalsCells
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Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2016 06 02; 534(7605):138.
Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. PMID: 26958840.
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Deregulated expression of the HSP40 family members Auxilin-1 and -2 is indicative of proteostasis imbalance and predicts patient outcome in Ph(+) leukemia. Exp Hematol Oncol. 2015; 5:5.
Vieri M, Geng H, Patterson JB, Panse J, Wilop S, Samali A, Chevet E, Kharabi Masouleh B. PMID: 26862466; PMCID: PMC4746784.
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PubMed Mentions:
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MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199. Cell Rep. 2015 Dec 29; 13(12):2715-27.
Benito JM, Godfrey L, Kojima K, Hogdal L, Wunderlich M, Geng H, Marzo I, Harutyunyan KG, Golfman L, North P, Kerry J, Ballabio E, Chonghaile TN, Gonzalo O, Qiu Y, Jeremias I, Debose L, O'Brien E, Ma H, Zhou P, Jacamo R, Park E, Coombes KR, Zhang N, Thomas DA, O'Brien S, Kantarjian HM, Leverson JD, Kornblau SM, Andreeff M, Müschen M, Zweidler-McKay PA, Mulloy JC, Letai A, Milne TA, Konopleva M. PMID: 26711339; PMCID: PMC4700051.
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PubMed Mentions:
67 Fields:
Translation:
HumansAnimalsCells
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Erratum: TET1 is a tumor suppressor of hematopoietic malignancy. Nat Immunol. 2015 Aug; 16(8):889.
Cimmino L, Dawlaty MM, Ndiaye-Lobry D, Yap YS, Bakogianni S, Yu Y, Bhattacharyya S, Shaknovich R, Geng H, Lobry C, Mullenders J, King B, Trimarchi T, Aranda-Orgilles B, Liu C, Shen S, Verma AK, Jaenisch R, Aifantis I. PMID: 26194287.
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PubMed Mentions:
7 Fields:
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Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia. Cancer Cell. 2015 Jul 13; 28(1):114-28.
Shojaee S, Caeser R, Buchner M, Park E, Swaminathan S, Hurtz C, Geng H, Chan LN, Klemm L, Hofmann WK, Qiu YH, Zhang N, Coombes KR, Paietta E, Molkentin J, Koeffler HP, Willman CL, Hunger SP, Melnick A, Kornblau SM, Müschen M. PMID: 26073130; PMCID: PMC4565502.
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PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
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Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia. Nat Immunol. 2015 Jul; 16(7):766-774.
Swaminathan S, Klemm L, Park E, Papaemmanuil E, Ford A, Kweon SM, Trageser D, Hasselfeld B, Henke N, Mooster J, Geng H, Schwarz K, Kogan SC, Casellas R, Schatz DG, Lieber MR, Greaves MF, Müschen M. PMID: 25985233; PMCID: PMC4475638.
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100 Fields:
Translation:
HumansAnimalsCells
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TET1 is a tumor suppressor of hematopoietic malignancy. Nat Immunol. 2015 Jun; 16(6):653-62.
Cimmino L, Dawlaty MM, Ndiaye-Lobry D, Yap YS, Bakogianni S, Yu Y, Bhattacharyya S, Shaknovich R, Geng H, Lobry C, Mullenders J, King B, Trimarchi T, Aranda-Orgilles B, Liu C, Shen S, Verma AK, Jaenisch R, Aifantis I. PMID: 25867473; PMCID: PMC4545281.
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125 Fields:
Translation:
HumansAnimalsCells
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Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015 May 21; 521(7552):357-61.
Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. PMID: 25799995; PMCID: PMC4441554.
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76 Fields:
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HumansAnimalsCells
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Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia. Nat Commun. 2015 Mar 10; 6:6471.
Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M. PMID: 25753524; PMCID: PMC4366523.
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PubMed Mentions:
29 Fields:
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HumansAnimalsCells
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Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia. Cancer Cell. 2015 Mar 09; 27(3):409-25.
Geng H, Hurtz C, Lenz KB, Chen Z, Baumjohann D, Thompson S, Goloviznina NA, Chen WY, Huan J, LaTocha D, Ballabio E, Xiao G, Lee JW, Deucher A, Qi Z, Park E, Huang C, Nahar R, Kweon SM, Shojaee S, Chan LN, Yu J, Kornblau SM, Bijl JJ, Ye BH, Ansel KM, Paietta E, Melnick A, Hunger SP, Kurre P, Tyner JW, Loh ML, Roeder RG, Druker BJ, Burger JA, Milne TA, Chang BH, Müschen M. PMID: 25759025; PMCID: PMC4618684.
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PubMed Mentions:
70 Fields:
Translation:
HumansCells
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IL10 receptor is a novel therapeutic target in DLBCLs. Leukemia. 2015 Aug; 29(8):1684-94.
Béguelin W, Sawh S, Chambwe N, Chan FC, Jiang Y, Choo JW, Scott DW, Chalmers A, Geng H, Tsikitas L, Tam W, Bhagat G, Gascoyne RD, Shaknovich R. PMID: 25733167.
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PubMed Mentions:
38 Fields:
Translation:
HumansCells
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Global promoter methylation analysis reveals novel candidate tumor suppressor genes in natural killer cell lymphoma. Clin Cancer Res. 2015 Apr 01; 21(7):1699-711.
Küçük C, Hu X, Jiang B, Klinkebiel D, Geng H, Gong Q, Bouska A, Iqbal J, Gaulard P, McKeithan TW, Chan WC. PMID: 25614448; PMCID: PMC4504988.
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PubMed Mentions:
47 Fields:
Translation:
HumansCells
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Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):E2219-28.
Kharabi Masouleh B, Geng H, Hurtz C, Chan LN, Logan AC, Chang MS, Huang C, Swaminathan S, Sun H, Paietta E, Melnick AM, Koeffler P, Müschen M. PMID: 24821775; PMCID: PMC4040579.
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PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells
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Variability in DNA methylation defines novel epigenetic subgroups of DLBCL associated with different clinical outcomes. Blood. 2014 Mar 13; 123(11):1699-708.
Chambwe N, Kormaksson M, Geng H, De S, Michor F, Johnson NA, Morin RD, Scott DW, Godley LA, Gascoyne RD, Melnick A, Campagne F, Shaknovich R. PMID: 24385541; PMCID: PMC3954051.
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PubMed Mentions:
53 Fields:
Translation:
HumansCells
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Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation. Blood. 2014 Feb 13; 123(7):1012-20.
Huang C, Geng H, Boss I, Wang L, Melnick A. PMID: 24277074; PMCID: PMC3924924.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
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A TAF4 coactivator function for E proteins that involves enhanced TFIID binding. Genes Dev. 2013 Jul 15; 27(14):1596-609.
Chen WY, Zhang J, Geng H, Du Z, Nakadai T, Roeder RG. PMID: 23873942; PMCID: PMC3731548.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint. Nat Med. 2013 Aug; 19(8):1014-22.
Swaminathan S, Huang C, Geng H, Chen Z, Harvey R, Kang H, Ng C, Titz B, Hurtz C, Sadiyah MF, Nowak D, Thoennissen GB, Rand V, Graeber TG, Koeffler HP, Carroll WL, Willman CL, Hall AG, Igarashi K, Melnick A, Müschen M. PMID: 23852341; PMCID: PMC3954721.
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PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
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Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile. Blood. 2013 Aug 15; 122(7):1293-304.
Cramer-Morales K, Nieborowska-Skorska M, Scheibner K, Padget M, Irvine DA, Sliwinski T, Haas K, Lee J, Geng H, Roy D, Slupianek A, Rassool FV, Wasik MA, Childers W, Copland M, Müschen M, Civin CI, Skorski T. PMID: 23836560; PMCID: PMC3744994.
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PubMed Mentions:
84 Fields:
Translation:
HumansAnimalsCells
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Imatinib disrupts lymphoma angiogenesis by targeting vascular pericytes. Blood. 2013 Jun 27; 121(26):5192-202.
Ruan J, Luo M, Wang C, Fan L, Yang SN, Cardenas M, Geng H, Leonard JP, Melnick A, Cerchietti L, Hajjar KA. PMID: 23632889; PMCID: PMC3695363.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction. Cell Rep. 2013 Jan 31; 3(1):116-27.
Wilkinson AC, Ballabio E, Geng H, North P, Tapia M, Kerry J, Biswas D, Roeder RG, Allis CD, Melnick A, de Bruijn MF, Milne TA. PMID: 23352661; PMCID: PMC3607232.
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PubMed Mentions:
83 Fields:
Translation:
HumansCells
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Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy. Blood. 2013 Mar 07; 121(10):1814-8.
Hsieh YT, Gang EJ, Geng H, Park E, Huantes S, Chudziak D, Dauber K, Schaefer P, Scharman C, Shimada H, Shojaee S, Klemm L, Parameswaran R, Loh M, Kang ES, Koo HH, Hofmann WK, Andrade J, Crooks GM, Willman CL, Müschen M, Papayannopoulou T, Heisterkamp N, Bönig H, Kim YM. PMID: 23319569; PMCID: PMC3591800.
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PubMed Mentions:
68 Fields:
Translation:
HumansAnimalsCells
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Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity. PLoS Genet. 2013; 9(1):e1003137.
De S, Shaknovich R, Riester M, Elemento O, Geng H, Kormaksson M, Jiang Y, Woolcock B, Johnson N, Polo JM, Cerchietti L, Gascoyne RD, Melnick A, Michor F. PMID: 23326238; PMCID: PMC3542081.
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PubMed Mentions:
71 Fields:
Translation:
HumansCells
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SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia. Blood. 2013 Jan 03; 121(1):148-55.
Ramezani-Rad P, Geng H, Hurtz C, Chan LN, Chen Z, Jumaa H, Melnick A, Paietta E, Carroll WL, Willman CL, Lefebvre V, Müschen M. PMID: 23152540; PMCID: PMC3538327.
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PubMed Mentions:
42 Fields:
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HumansAnimalsCells
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Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia. Cancer Discov. 2012 Nov; 2(11):1004-23.
Geng H, Brennan S, Milne TA, Chen WY, Li Y, Hurtz C, Kweon SM, Zickl L, Shojaee S, Neuberg D, Huang C, Biswas D, Xin Y, Racevskis J, Ketterling RP, Luger SM, Lazarus H, Tallman MS, Rowe JM, Litzow MR, Guzman ML, Allis CD, Roeder RG, Müschen M, Paietta E, Elemento O, Melnick AM. PMID: 23107779; PMCID: PMC3516186.
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PubMed Mentions:
50 Fields:
Translation:
HumansCells
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Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC. Blood. 2011 Oct 13; 118(15):4174-8.
Nahar R, Ramezani-Rad P, Mossner M, Duy C, Cerchietti L, Geng H, Dovat S, Jumaa H, Ye BH, Melnick A, Müschen M. PMID: 21856866; PMCID: PMC3204735.
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PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
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BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature. 2011 May 19; 473(7347):384-8.
Duy C, Hurtz C, Shojaee S, Cerchietti L, Geng H, Swaminathan S, Klemm L, Kweon SM, Nahar R, Braig M, Park E, Kim YM, Hofmann WK, Herzog S, Jumaa H, Koeffler HP, Yu JJ, Heisterkamp N, Graeber TG, Wu H, Ye BH, Melnick A, Müschen M. PMID: 21593872; PMCID: PMC3597744.
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PubMed Mentions:
114 Fields:
Translation:
HumansAnimalsCells
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Virtual CGH: an integrative approach to predict genetic abnormalities from gene expression microarray data applied in lymphoma. BMC Med Genomics. 2011 Apr 12; 4:32.
Geng H, Iqbal J, Chan WC, Ali HH. PMID: 21486456; PMCID: PMC3086850.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis. Blood. 2010 Dec 09; 116(24):5247-55.
Velichutina I, Shaknovich R, Geng H, Johnson NA, Gascoyne RD, Melnick AM, Elemento O. PMID: 20736451; PMCID: PMC3012542.
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PubMed Mentions:
151 Fields:
Translation:
HumansCells
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DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma. Blood. 2010 Nov 18; 116(20):e81-9.
Shaknovich R, Geng H, Johnson NA, Tsikitas L, Cerchietti L, Greally JM, Gascoyne RD, Elemento O, Melnick A. PMID: 20610814; PMCID: PMC2993635.
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PubMed Mentions:
83 Fields:
Translation:
HumansCells
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Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma. Blood. 2010 Feb 04; 115(5):1026-36.
Iqbal J, Weisenburger DD, Greiner TC, Vose JM, McKeithan T, Kucuk C, Geng H, Deffenbacher K, Smith L, Dybkaer K, Nakamura S, Seto M, Delabie J, Berger F, Loong F, Au WY, Ko YH, Sng I, Armitage JO, Chan WC, International Peripheral T-Cell Lymphoma Project. PMID: 19965671; PMCID: PMC2817630.
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PubMed Mentions:
152 Fields:
Translation:
HumansCells
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A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy. Clin Cancer Res. 2009 Sep 01; 15(17):5494-502.
Choi WW, Weisenburger DD, Greiner TC, Piris MA, Banham AH, Delabie J, Braziel RM, Geng H, Iqbal J, Lenz G, Vose JM, Hans CP, Fu K, Smith LM, Li M, Liu Z, Gascoyne RD, Rosenwald A, Ott G, Rimsza LM, Campo E, Jaffe ES, Jaye DL, Staudt LM, Chan WC. PMID: 19706817; PMCID: PMC7289055.
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PubMed Mentions:
223 Fields:
Translation:
Humans
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Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies. Leukemia. 2009 Jun; 23(6):1139-51.
Iqbal J, Kucuk C, Deleeuw RJ, Srivastava G, Tam W, Geng H, Klinkebiel D, Christman JK, Patel K, Cao K, Shen L, Dybkaer K, Tsui IF, Ali H, Shimizu N, Au WY, Lam WL, Chan WC. PMID: 19194464.
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PubMed Mentions:
86 Fields:
Translation:
HumansCells
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Clonal evolution in t(14;18)-positive follicular lymphoma, evidence for multiple common pathways, and frequent parallel clonal evolution. Clin Cancer Res. 2008 Nov 15; 14(22):7180-7.
d'Amore F, Chan E, Iqbal J, Geng H, Young K, Xiao L, Hess MM, Sanger WG, Smith L, Wiuf C, Hagberg O, Fu K, Chan WC, Dave BJ. PMID: 19010834.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Message Passing Clustering (MPC): a knowledge-based framework for clustering under biological constraints. Int J Data Min Bioinform. 2008; 2(2):95-120.
Geng H, Deng X, Ali HH. PMID: 18767349.
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A Hidden Markov Model Approach for Prediction of Genomic Alterations from Gene Expression Profiling. In Ion Mandoiu, Raj Sunderraman and Alexander Zelikovsky (Eds.) Lecture Notes in Computer Science (LNCS). 2008; 4983:414-426. Springer, Heidelberg.
Geng H, Ali HH, Chan WC.
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A Hidden Markov Model approach to predicting yeast gene function from sequential gene expression data. Int J Bioinform Res Appl. 2008; 4(3):263-73.
Deng X, Geng H, Ali HH. PMID: 18640903.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Genome wide transcriptional analysis of resting and IL2 activated human natural killer cells: gene expression signatures indicative of novel molecular signaling pathways. BMC Genomics. 2007 Jul 10; 8:230.
Dybkaer K, Iqbal J, Zhou G, Geng H, Xiao L, Schmitz A, d'Amore F, Chan WC. PMID: 17623099; PMCID: PMC1959522.
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PubMed Mentions:
55 Fields:
Translation:
HumansCells
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Cross-platform analysis of cancer biomarkers: a Bayesian network approach to incorporating mass spectrometry and microarray data. Cancer Inform. 2007 Apr 29; 3:183-202.
Deng X, Geng H, Ali HH. PMID: 19455243; PMCID: PMC2675834.
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PubMed Mentions:
5
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Link test--A statistical method for finding prostate cancer biomarkers. Comput Biol Chem. 2006 Dec; 30(6):425-33.
Deng X, Geng H, Bastola DR, Ali HH. PMID: 17126079; PMCID: PMC1941704.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Dynamics of asynchronous random Boolean networks with asynchrony generated by stochastic processes. Biosystems. 2007 Mar; 88(1-2):16-34.
Deng X, Geng H, Matache MT. PMID: 16870321.
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PubMed Mentions:
3 Fields:
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Joint learning of gene functions--a Bayesian network model approach. J Bioinform Comput Biol. 2006 Apr; 4(2):217-39.
Deng X, Geng H, Ali HH. PMID: 16819781.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Molecular and Morphological Analyses of the Sportive Lemurs (Family Megaladapidae: Genus Lepilemur) Reveals 11 Previously Unrecognized Species. Special Publications Museum of Texas Tech University. 2006; 49(SP):1-49.
Louis EE, Jr., Engberg SE, Lei R, Geng H, Sommer JA, Randriamampionona R, Randriamanana JC, Zaonarivelo JR, Andriantompohavana R, Randria G, Ramaromilanto B, Rakotoarisoa G, Rooney A, Brenneman RA.
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EXAMINE: a computational approach to reconstructing gene regulatory networks. Biosystems. 2005 Aug; 81(2):125-36.
Deng X, Geng H, Ali H. PMID: 15951103.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Mining Gene Microarray Data with Adaptive Feature Scaling. Proceedings of 4th IEEE International Conference on Electro Information Technology (EIT’05). 2005; 1-6.
Geng H, Deng X, Ali HH.
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On Clustering Biological Data Using Unsupervised and Semi-supervised Message Passing. Proceedings of IEEE 5th Symposium on Bioinformatics and Bioengineering (BIBE). 2005; 294-298.
Geng H, Deng X, Bastola DR, Ali HH.
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Learning yeast gene functions from heterogeneous sources of data using hybrid weighted Bayesian networks. Proc IEEE Comput Syst Bioinform Conf. 2005; 25-34.
Deng X, Geng H, Ali H. PMID: 16447959.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells