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Huong Kratochvil, PhD

Title(s)Postdoctoral Scholar, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address555 Mission Bay Blvd South
San Francisco CA 94158
Phone--
ORCID ORCID Icon0000-0001-8039-6823 Additional info
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    Collapse Biography 
    Collapse Education and Training
    The University of Texas at Austin, Austin, TXB.S. 05/2010Chemistry
    University of Wisconsin-Madison, Madison, WIPh.D.10/2016Chemistry

    Collapse Research 
    Collapse Research Activities and Funding
    Proton Conduction Pathways in Proton Channel Proteins
    NIH/NIGMS K99GM138753Sep 1, 2020 - Aug 31, 2022
    Role Description: The flow of protons across membranes is critical for bioenergetics, signaling and other biological processes. The transport of protons across cellular membranes could be potentially toxic to cells had proton channel proteins not fine-tuned their selectivity and rate of transmission (conductivity). This proposal aims to understand the mechanisms by which these proton channels achieve and fine-tune proton selectivity and conductivity through the detailed study of the influenza A virus matrix protein 2 and synthetic designed proton channels.
    Proton Conduction Pathways in Proton Channel Proteins
    NIH K99GM138753Sep 1, 2020 - Aug 31, 2022
    Role: Principal Investigator
    A structural and biophysical study of the matrix proteins in influenza A/B viruses: Mechanisms of proton conduction and roles of protein-protein interactions
    NIH F32GM125217Sep 1, 2017 - Aug 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking. Sci Adv. 2021 04; 7(16). PMID: 33853786.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking. bioRxiv. 2020 Nov 24. Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Martins LC, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, Peters JK, Moritz M, Herrera N, Kratochvil HT, Aimon A, Bennett JM, Neto JB, Cohen AE, Dias A, Douangamath A, Dunnett L, Fedorov O, Ferla MP, Fuchs M, Gorrie-Stone TJ, Holton JM, Johnson MG, Krojer T, Meigs G, Powell AJ, Rack JGM, Rangel VL, Russi S, Skyner RE, Smith CA, Soares AS, Wierman JL, Zhu K, Jura N, Ashworth A, Irwin J, Thompson MC, Gestwicki JE, von Delft F, Shoichet BK, Fraser JS, Ahel I. PMID: 33269349.
      View in: PubMed   Mentions:
    3. An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science. 2020 12 18; 370(6523):1473-1479. Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, Walter P, Manglik A. PMID: 33154106.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    4. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science. 2020 12 04; 370(6521). Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbølle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, , Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL, , Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, Palmarini M, Shokat KM, García-Sastre A, Rassen JA, Grosse R, Rosenberg OS, Verba KA, Basler CF, Vignuzzi M, Peden AA, Beltrao P, Krogan NJ. PMID: 33060197.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    5. Roles of Hydrogen-Bonding Networks in Proton Channel Function as Revealed through de novo Designed Proton Channels. Biophysical Journal. 2020 Feb 1; 118(3):483a. Huong T. Kratochvil, John M. Nicoludis, William F. DeGrado. .
      View in: Publisher Site   Mentions:
    6. Synthesis and application of the blue fluorescent amino acid l-4-cyanotryptophan to assess peptide-membrane interactions. Chem Commun (Camb). 2019 Apr 25; 55(35):5095-5098. Zhang K, Ahmed IA, Kratochvil HT, DeGrado WF, Gai F, Jo H. PMID: 30957824.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    7. Glutamine Side Chain 13C-18O as a Nonperturbative IR Probe of Amyloid Fibril Hydration and Assembly. J Am Chem Soc. 2019 05 08; 141(18):7320-7326. Wu H, Saltzberg DJ, Kratochvil HT, Jo H, Sali A, DeGrado WF. PMID: 30998340.
      View in: PubMed   Mentions: 1     Fields:    
    8. Designed peptides that assemble into cross-a amyloid-like structures. Nat Chem Biol. 2018 09; 14(9):870-875. Zhang SQ, Huang H, Yang J, Kratochvil HT, Lolicato M, Liu Y, Shu X, Liu L, DeGrado WF. PMID: 30061717.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    9. Two-dimensional infrared (2D IR) spectroscopy for elucidating ion occupancies in the selectivity filter of ion channels1. Biomedical Spectroscopy and Imaging. 2018 May 7; 7(1-2):3-15. Huong T. Kratochvil, Martin T. Zanni. .
      View in: Publisher Site   Mentions:
    10. De Novo Design of Cross-a Amyloid-Like Fibrils with Cellular Activity. Biophysical Journal. 2018 Feb 1; 114(3):410a. Shao-Qing Zhang, Lijun Liu, Junjiao Yang, Marco Lolicato, Huong Kratochvil, Xiaokun Shu, William F. DeGrado. .
      View in: Publisher Site   Mentions:
    11. Proton Stabilization and Conduction Pathway in the Matrix Protein M2. Biophysical Journal. 2018 Feb 1; 114(3):240a-241a. Huong T. Kratochvil, Jessica L. Thomaston, Feng Gai, William F. DeGrado. .
      View in: Publisher Site   Mentions:
    12. Probing the Effects of Gating on the Ion Occupancy of the K+ Channel Selectivity Filter Using Two-Dimensional Infrared Spectroscopy. J Am Chem Soc. 2017 07 05; 139(26):8837-8845. Kratochvil HT, Maj M, Matulef K, Annen AW, Ostmeyer J, Perozo E, Roux B, Valiyaveetil FI, Zanni MT. PMID: 28472884.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    13. Solvent-Independent Anharmonicity for Carbonyl Oscillators. J Phys Chem B. 2017 03 16; 121(10):2331-2338. Schneider SH, Kratochvil HT, Zanni MT, Boxer SG. PMID: 28225620.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    14. Instantaneous ion configurations in the K+ ion channel selectivity filter revealed by 2D IR spectroscopy. Science. 2016 09 02; 353(6303):1040-1044. Kratochvil HT, Carr JK, Matulef K, Annen AW, Li H, Maj M, Ostmeyer J, Serrano AL, Raghuraman H, Moran SD, Skinner JL, Perozo E, Roux B, Valiyaveetil FI, Zanni MT. PMID: 27701114.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    15. Counting tagged molecules one by one: Quantitative photoactivation and bleaching of photoactivatable fluorophores. J Chem Phys. 2015 Sep 14; 143(10):104201. Kratochvil HT, Ha DG, Zanni MT. PMID: 26374025.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    16. Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient ß-sheet. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19285-90. Buchanan LE, Dunkelberger EB, Tran HQ, Cheng PN, Chiu CC, Cao P, Raleigh DP, de Pablo JJ, Nowick JS, Zanni MT. PMID: 24218609.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
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