Ian Welsh, PhD

Title(s)Postdoctoral Scholar, Orofacial Sciences
SchoolSchool of Dentistry
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    Morphogenesis represents a critical and dynamic utilization of genomic information in the life history of an organism, and thus a powerful system for advancing our understanding of genome regulation and function. My work focuses on the establishment and characterization genetic models of embryonic morphogenesis as a means to advance a more quantitative understanding of genome function. The goal of my research is to elucidate the cis-, trans-, and higher order basis of genomic information processing in the context of developing embryos. This processing occurs via the dynamics of transcriptional regulation and intercellular signaling, and is critical for coordinating morphogenic cellular behavior. I am leveraging genome wide approaches and developmental genetics to characterize both evolutionary and pathological variation in regulatory networks controlling morphogenesis along the anterior-posterior axis of the upper jaw.

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    Genomic regulation of midfacial outgrowth variation in evolution and pathology
    NIH F32 DE026950-01Mar 6, 2017 - Mar 6, 2020
    Role: PI
    Genomic regulation of midfacial outgrowth variation in evolution and pathology
    NIH/NIDCR F32DE026950Mar 6, 2017 - Mar 5, 2020
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Welsh IC, Hart J, Brown JM, Hansen K, Rocha Marques M, Aho RJ, Grishina I, Hurtado R, Herzlinger D, Ferretti E, Garcia-Garcia MJ, Selleri L. Pbx loss in cranial neural crest, unlike in epithelium, results in cleft palate only and a broader midface. J Anat. 2018 Aug; 233(2):222-242. PMID: 29797482.
      View in: PubMed
    2. Welsh IC, Kwak H, Chen FL, Werner M, Shopland LS, Danko CG, Lis JT, Zhang M, Martin JF, Kurpios NA. Chromatin Architecture of the Pitx2 Locus Requires CTCF- and Pitx2-Dependent Asymmetry that Mirrors Embryonic Gut Laterality. Cell Rep. 2015 Oct 13; 13(2):337-49. PMID: 26411685; PMCID: PMC4617833.
    3. Mahadevan A, Welsh IC, Sivakumar A, Gludish DW, Shilvock AR, Noden DM, Huss D, Lansford R, Kurpios NA. The left-right Pitx2 pathway drives organ-specific arterial and lymphatic development in the intestine. Dev Cell. 2014 Dec 22; 31(6):690-706. PMID: 25482882; PMCID: PMC4326534.
    4. Welsh IC, Thomsen M, Gludish DW, Alfonso-Parra C, Bai Y, Martin JF, Kurpios NA. Integration of left-right Pitx2 transcription and Wnt signaling drives asymmetric gut morphogenesis via Daam2. Dev Cell. 2013 Sep 30; 26(6):629-44. PMID: 24091014; PMCID: PMC3965270.
    5. Lyndaker AM, Modzelewski AJ, Welsh IC. Reproductive and developmental genomics retreat at Cornell University, 2012. Mol Reprod Dev. 2012 Sep; 79(9):588-91. PMID: 22933246; PMCID: PMC4104196.
    6. Welsh IC, O'Brien TP. Signaling integration in the rugae growth zone directs sequential SHH signaling center formation during the rostral outgrowth of the palate. Dev Biol. 2009 Dec 01; 336(1):53-67. PMID: 19782673; PMCID: PMC2789450.
    7. Munroe RJ, Prabhu V, Acland GM, Johnson KR, Harris BS, O'Brien TP, Welsh IC, Noden DM, Schimenti JC. Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial abnormalities and reduced body mass. BMC Dev Biol. 2009 Apr 20; 9:27. PMID: 19379485; PMCID: PMC2676275.
    8. Welsh IC, Hagge-Greenberg A, O'Brien TP. A dosage-dependent role for Spry2 in growth and patterning during palate development. Mech Dev. 2007 Sep-Oct; 124(9-10):746-61. PMID: 17693063; PMCID: PMC2043129.
    9. Han L, Dias Figueiredo M, Berghorn KA, Iwata TN, Clark-Campbell PA, Welsh IC, Wang W, O'brien TP, Lin DM, Roberson MS. Analysis of the gene regulatory program induced by the homeobox transcription factor distal-less 3 in mouse placenta. Endocrinology. 2007 Mar; 148(3):1246-54. PMID: 17110422.
      View in: PubMed
    10. Burgess RW, Peterson KA, Johnson MJ, Roix JJ, Welsh IC, O'Brien TP. Evidence for a conserved function in synapse formation reveals Phr1 as a candidate gene for respiratory failure in newborn mice. Mol Cell Biol. 2004 Feb; 24(3):1096-105. PMID: 14729956; PMCID: PMC321423.
    11. Frank AC, Meyers KA, Welsh IC, O'Brien TP. Development of an enhanced GFP-based dual-color reporter to facilitate genetic screens for the recovery of mutations in mice. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14103-8. PMID: 14615591; PMCID: PMC283553.
    12. Krebs LT, Iwai N, Nonaka S, Welsh IC, Lan Y, Jiang R, Saijoh Y, O'Brien TP, Hamada H, Gridley T. Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes Dev. 2003 May 15; 17(10):1207-12. PMID: 12730124; PMCID: PMC196059.
    13. Welsh IC, O'Brien TP. Loss of late primitive streak mesoderm and interruption of left-right morphogenesis in the Ednrb(s-1Acrg) mutant mouse. Dev Biol. 2000 Sep 01; 225(1):151-68. PMID: 10964471.
      View in: PubMed
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