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Ian Welsh, PhD

Title(s)Postdoc Scholar - Employee, Orofacial Sciences
SchoolSchool of Dentistry
Address513 Parnassus Ave, HSW
San Francisco CA 94143
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    Morphogenesis represents a critical and dynamic utilization of genomic information in the life history of an organism, and thus a powerful system for advancing our understanding of genome regulation and function. My work focuses on the establishment and characterization genetic models of embryonic morphogenesis as a means to advance a more quantitative understanding of genome function. The goal of my research is to elucidate the cis-, trans-, and higher order basis of genomic information processing in the context of developing embryos. This processing occurs via the dynamics of transcriptional regulation and intercellular signaling, and is critical for coordinating morphogenic cellular behavior. I am leveraging genome wide approaches and developmental genetics to characterize both evolutionary and pathological variation in regulatory networks controlling morphogenesis along the anterior-posterior axis of the upper jaw.

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    Genomic regulation of midfacial outgrowth variation in evolution and pathology
    NIH F32 DE026950-01Mar 6, 2017 - Mar 6, 2020
    Role: PI
    Genomic regulation of midfacial outgrowth variation in evolution and pathology
    NIH/NIDCR F32DE026950Mar 6, 2017 - Mar 5, 2020
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pbx loss in cranial neural crest, unlike in epithelium, results in cleft palate only and a broader midface. J Anat. 2018 08; 233(2):222-242. Welsh IC, Hart J, Brown JM, Hansen K, Rocha Marques M, Aho RJ, Grishina I, Hurtado R, Herzlinger D, Ferretti E, Garcia-Garcia MJ, Selleri L. PMID: 29797482.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    2. Chromatin Architecture of the Pitx2 Locus Requires CTCF- and Pitx2-Dependent Asymmetry that Mirrors Embryonic Gut Laterality. Cell Rep. 2015 Oct 13; 13(2):337-49. Welsh IC, Kwak H, Chen FL, Werner M, Shopland LS, Danko CG, Lis JT, Zhang M, Martin JF, Kurpios NA. PMID: 26411685.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    3. The left-right Pitx2 pathway drives organ-specific arterial and lymphatic development in the intestine. Dev Cell. 2014 Dec 22; 31(6):690-706. Mahadevan A, Welsh IC, Sivakumar A, Gludish DW, Shilvock AR, Noden DM, Huss D, Lansford R, Kurpios NA. PMID: 25482882.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    4. Integration of left-right Pitx2 transcription and Wnt signaling drives asymmetric gut morphogenesis via Daam2. Dev Cell. 2013 Sep 30; 26(6):629-44. Welsh IC, Thomsen M, Gludish DW, Alfonso-Parra C, Bai Y, Martin JF, Kurpios NA. PMID: 24091014.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    5. Reproductive and developmental genomics retreat at Cornell University, 2012. Mol Reprod Dev. 2012 Sep; 79(9):588-91. Lyndaker AM, Modzelewski AJ, Welsh IC. PMID: 22933246.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    6. Signaling integration in the rugae growth zone directs sequential SHH signaling center formation during the rostral outgrowth of the palate. Dev Biol. 2009 Dec 01; 336(1):53-67. Welsh IC, O'Brien TP. PMID: 19782673.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    7. Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial abnormalities and reduced body mass. BMC Dev Biol. 2009 Apr 20; 9:27. Munroe RJ, Prabhu V, Acland GM, Johnson KR, Harris BS, O'Brien TP, Welsh IC, Noden DM, Schimenti JC. PMID: 19379485.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    8. A dosage-dependent role for Spry2 in growth and patterning during palate development. Mech Dev. 2007 Sep-Oct; 124(9-10):746-61. Welsh IC, Hagge-Greenberg A, O'Brien TP. PMID: 17693063.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    9. Analysis of the gene regulatory program induced by the homeobox transcription factor distal-less 3 in mouse placenta. Endocrinology. 2007 Mar; 148(3):1246-54. Han L, Dias Figueiredo M, Berghorn KA, Iwata TN, Clark-Campbell PA, Welsh IC, Wang W, O'brien TP, Lin DM, Roberson MS. PMID: 17110422.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    10. Evidence for a conserved function in synapse formation reveals Phr1 as a candidate gene for respiratory failure in newborn mice. Mol Cell Biol. 2004 Feb; 24(3):1096-105. Burgess RW, Peterson KA, Johnson MJ, Roix JJ, Welsh IC, O'Brien TP. PMID: 14729956.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    11. Development of an enhanced GFP-based dual-color reporter to facilitate genetic screens for the recovery of mutations in mice. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14103-8. Frank AC, Meyers KA, Welsh IC, O'Brien TP. PMID: 14615591.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes Dev. 2003 May 15; 17(10):1207-12. Krebs LT, Iwai N, Nonaka S, Welsh IC, Lan Y, Jiang R, Saijoh Y, O'Brien TP, Hamada H, Gridley T. PMID: 12730124.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    13. Loss of late primitive streak mesoderm and interruption of left-right morphogenesis in the Ednrb(s-1Acrg) mutant mouse. Dev Biol. 2000 Sep 01; 225(1):151-68. Welsh IC, O'Brien TP. PMID: 10964471.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
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