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Ida Sim, PhD, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityM.D.1990
    Stanford UniversityPhD1997Medical Informatics
    Collapse Awards and Honors
    American Society for Clinical Investigation2010Elected Member
    American College of Medial Informatics2007Elected Fellow
    American Medical Informatics Association2005Leadership Award
    White House Office of Science Technology and Policy2000United States Presidential Early Career Award for Scientists and Engineers

    Collapse Overview 
    Collapse Overview
    Ida Sim, MD, PhD is a primary care physician, informatics researcher, and entrepreneur. She is a Professor of Medicine at the University of California, San Francisco, where she co-directs Informatics and Research Innovation at UCSF's Clinical and Translational Sciences Institute, and is Director of Digital Health for the Division of General Internal Medicine. Her current research focuses on the use of mobile apps and sensors to improve health and manage disease for populations and individuals, and to make clinical research faster and less expensive. She is a co-founder of Open mHealth, a non-profit organization that is breaking down barriers to mobile health app and data integration through an open software architecture. Open mHealth is an official working group of the IEEE Standards Association and is on track to becoming a global IEEE standard.

    Dr. Sim is also an international leader in clinical trial data sharing. In 2005, Dr. Sim was the founding Project Coordinator of the World Health Organization's International Clinical Trials Registry Platform, where she led the establishment of the first global policy on clinical trial registration and defined the common 20-item Trial Registration Data Set that all registers worldwide adhere to. She served on the Institute of Medicine's committee on Strategies of Responsible Sharing of Clinical Trial Data and is a Co-founder of Vivli, the world's largest data sharing platform for participant-level clinical trial data.

    Dr. Sim has served on multiple advisory committees on health information infrastructure for clinical care and research, including committees of the National Research Council and Institute of Medicine. She is a recipient of the United States Presidential Early Career Award for Scientists and Engineers (PECASE), a Fellow of the American College of Medical Informatics, and a member of the American Society for Clinical Investigation.

    Collapse Research 
    Collapse Research Activities and Funding
    Mobile Patient-Reported Outcomes for Value and Effectiveness (mPROVE)
    AHRQ U18HS026883Sep 1, 2019 - Aug 31, 2022
    Role: Principal Investigator
    Open mHealth: Community-Based Data and Metadata Standards for Mobile Health
    NIH/NIBIB R24EB025845Aug 17, 2017 - May 31, 2020
    Role: Principal Investigator
    Ontology-Based Integration of Human Studies Data
    NIH/NCRR R01RR026040Sep 9, 2009 - May 31, 2013
    Role: Principal Investigator
    The Trial Bank Project
    NIH/NLM R01LM006780Jul 1, 1999 - Mar 31, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Global Health
    Collapse Websites
    Collapse In The News
    Collapse Featured Presentations
    Collapse Twitter
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Sim I. Mobile Devices and Health. N Engl J Med. 2019 09 05; 381(10):956-968. PMID: 31483966.
      View in: PubMed
    2. Li R, Sim I. How Clinical Trial Data Sharing Platforms Can Advance the Study of Biomarkers. J Law Med Ethics. 2019 Sep; 47(3):369-373. PMID: 31560635.
      View in: PubMed
    3. Odineal DD, Marois MT, Ward D, Schmid CH, Cabrera R, Sim I, Wang Y, Wilsey B, Duan N, Henry SG, Kravitz RL. Effect of Mobile Device-Assisted N-of-1 Trial Participation on Analgesic Prescribing for Chronic Pain: Randomized Controlled Trial. J Gen Intern Med. 2019 Aug 28. PMID: 31463686.
      View in: PubMed
    4. Hekler EB, Klasnja P, Chevance G, Golaszewski NM, Lewis D, Sim I. Why we need a small data paradigm. BMC Med. 2019 07 17; 17(1):133. PMID: 31311528.
      View in: PubMed
    5. Li T, Saldanha IJ, Jap J, Smith BT, Canner J, Hutfless SM, Branch V, Carini S, Chan W, de Bruijn B, Wallace BC, Walsh SA, Whamond EJ, Murad MH, Sim I, Berlin JA, Lau J, Dickersin K, Schmid CH. A randomized trial provided new evidence on the accuracy and efficiency of traditional vs. electronically annotated abstraction approaches in systematic reviews. J Clin Epidemiol. 2019 Jul 11; 115:77-89. PMID: 31302205.
      View in: PubMed
    6. Zhang X, Hailu B, Tabor DC, Gold R, Sayre MH, Sim I, Jean-Francois B, Casnoff CA, Cullen T, Thomas VA, Artiles L, Williams K, Le PT, Aklin CF, James R. Role of Health Information Technology in Addressing Health Disparities: Patient, Clinician, and System Perspectives. Med Care. 2019 Jun; 57 Suppl 6 Suppl 2:S115-S120. PMID: 31095049.
      View in: PubMed
    7. Kravitz RL, Schmid CH, Sim I. Finding Benefit in n-of-1 Trials-Reply. JAMA Intern Med. 2019 Mar 01; 179(3):455. PMID: 30830195.
      View in: PubMed
    8. Kravitz RL, Sim I, Duan N. A Case for n-of-1 Trials-Reply. JAMA Intern Med. 2019 Mar 01; 179(3):453. PMID: 30830192.
      View in: PubMed
    9. Fukushima M, Austin C, Sato N, Maruyama T, Navarro E, Rocca M, Demotes J, Haendel M, Volchenboum SL, Cowperthwaite M, Silverstein JC, Webb C, Sim I, Chase M, Speakman J, Augustine E, Ford DE, Kush R. The Global academic research organization network: Data sharing to cure diseases and enable learning health systems. Learn Health Syst. 2019 Jan; 3(1):e10073. PMID: 31245596.
      View in: PubMed
    10. Rebecca Li, Jessica Scott, Frank Rockhold, Nina Hill, Julie Wood, Ida Sim. Moving Data Sharing Forward: The Launch of the Vivli Platform. NAM Perspectives. 2018 Nov 19; 8(11).
      View in: Publisher Site
    11. Whitney RL, Ward DH, Marois MT, Schmid CH, Sim I, Kravitz RL. Patient Perceptions of Their Own Data in mHealth Technology-Enabled N-of-1 Trials for Chronic Pain: Qualitative Study. JMIR Mhealth Uhealth. 2018 Oct 11; 6(10):e10291. PMID: 30309834.
      View in: PubMed
    12. Kravitz RL, Schmid CH, Marois M, Wilsey B, Ward D, Hays RD, Duan N, Wang Y, MacDonald S, Jerant A, Servadio JL, Haddad D, Sim I. Effect of Mobile Device-Supported Single-Patient Multi-crossover Trials on Treatment of Chronic Musculoskeletal Pain: A Randomized Clinical Trial. JAMA Intern Med. 2018 10 01; 178(10):1368-1377. PMID: 30193253.
      View in: PubMed
    13. Kumar S, Abowd G, Abraham WT, al'Absi M, Chau DHP, Ertin E, Estrin D, Ganesan D, Hnat T, Hossain SM, Ives Z, Kerr J, Marlin BM, Murphy S, Rehg JM, Nahum-Shani I, Shetty V, Sim I, Spring B, Srivastava M, Wetter D. Center of Excellence for Mobile Sensor Data-to-Knowledge (MD2K). IEEE Pervasive Comput. 2017 Apr-Jun; 16(2):18-22. PMID: 29276451.
      View in: PubMed
    14. Saldanha IJ, Schmid CH, Lau J, Dickersin K, Berlin JA, Jap J, Smith BT, Carini S, Chan W, De Bruijn B, Wallace BC, Hutfless SM, Sim I, Murad MH, Walsh SA, Whamond EJ, Li T. Evaluating Data Abstraction Assistant, a novel software application for data abstraction during systematic reviews: protocol for a randomized controlled trial. Syst Rev. 2016 11 22; 5(1):196. PMID: 27876082.
      View in: PubMed
    15. Bierer BE, Li R, Barnes M, Sim I. A Global, Neutral Platform for Sharing Trial Data. N Engl J Med. 2016 Jun 23; 374(25):2411-3. PMID: 27168194.
      View in: PubMed
    16. He Z, Ryan P, Hoxha J, Wang S, Carini S, Sim I, Weng C. Multivariate analysis of the population representativeness of related clinical studies. J Biomed Inform. 2016 Apr; 60:66-76. PMID: 26820188.
      View in: PubMed
    17. Elliott JH, Grimshaw J, Altman R, Bero L, Goodman SN, Henry D, Macleod M, Tovey D, Tugwell P, White H, Sim I. Informatics: Make sense of health data. Nature. 2015 Nov 05; 527(7576):31-2. PMID: 26536942.
      View in: PubMed
    18. Kumar S, Abowd GD, Abraham WT, al'Absi M, Beck JG, Chau DH, Condie T, Conroy DE, Ertin E, Estrin D, Ganesan D, Lam C, Marlin B, Marsh CB, Murphy SA, Nahum-Shani I, Patrick K, Rehg JM, Sharmin M, Shetty V, Sim I, Spring B, Srivastava M, Wetter DW. Center of excellence for mobile sensor data-to-knowledge (MD2K). J Am Med Inform Assoc. 2015 Nov; 22(6):1137-42. PMID: 26555017.
      View in: PubMed
    19. Barr C, Marois M, Sim I, Schmid CH, Wilsey B, Ward D, Duan N, Hays RD, Selsky J, Servadio J, Schwartz M, Dsouza C, Dhammi N, Holt Z, Baquero V, MacDonald S, Jerant A, Sprinkle R, Kravitz RL. The PREEMPT study - evaluating smartphone-assisted n-of-1 trials in patients with chronic pain: study protocol for a randomized controlled trial. Trials. 2015 Feb 27; 16:67. PMID: 25881274.
      View in: PubMed
    20. He Z, Carini S, Sim I, Weng C. Visual aggregate analysis of eligibility features of clinical trials. J Biomed Inform. 2015 Apr; 54:241-55. PMID: 25615940.
      View in: PubMed
    21. Ross J, Neylan T, Weiner M, Chao L, Samuelson K, Sim I. Towards Constructing a New Taxonomy for Psychiatry Using Self-reported Symptoms. Stud Health Technol Inform. 2015; 216:736-40. PMID: 26262149.
      View in: PubMed
    22. He Z, Carini S, Hao T, Sim I, Weng C. A method for analyzing commonalities in clinical trial target populations. AMIA Annu Symp Proc. 2014; 2014:1777-86. PMID: 25954450.
      View in: PubMed
    23. Brennan PF, Valdez R, Alexander G, Arora S, Bernstam EV, Edmunds M, Kirienko N, Martin RD, Sim I, Skiba D, Rosenbloom T. Patient-centered care, collaboration, communication, and coordination: a report from AMIA's 2013 Policy Meeting. J Am Med Inform Assoc. 2015 Apr; 22(e1):e2-6. PMID: 25359545.
      View in: PubMed
    24. DePasse JW, Chen CE, Sawyer A, Jethwani K, Sim I. Academic Medical Centers as digital health catalysts. Healthc (Amst). 2014 Sep; 2(3):173-6. PMID: 26250503.
      View in: PubMed
    25. Sim I, Tu SW, Carini S, Lehmann HP, Pollock BH, Peleg M, Wittkowski KM. The Ontology of Clinical Research (OCRe): an informatics foundation for the science of clinical research. J Biomed Inform. 2014 Dec; 52:78-91. PMID: 24239612.
      View in: PubMed
    26. Roumiantseva D, Carini S, Sim I, Wagner TH. Sponsorship and design characteristics of trials registered in ClinicalTrials.gov. Contemp Clin Trials. 2013 Mar; 34(2):348-55. PMID: 23380028.
      View in: PubMed
    27. Ochs C, Agrawal A, Perl Y, Halper M, Tu SW, Carini S, Sim I, Noy N, Musen M, Geller J. Deriving an abstraction network to support quality assurance in OCRe. AMIA Annu Symp Proc. 2012; 2012:681-9. PMID: 23304341.
      View in: PubMed
    28. Sim I, Carini S, Tu SW, Detwiler LT, Brinkley J, Mollah SA, Burke K, Lehmann HP, Chakraborty S, Wittkowski KM, Pollock BH, Johnson TM, Huser V. Ontology-based federated data access to human studies information. AMIA Annu Symp Proc. 2012; 2012:856-65. PMID: 23304360.
      View in: PubMed
    29. Chen C, Haddad D, Selsky J, Hoffman JE, Kravitz RL, Estrin DE, Sim I. Making sense of mobile health data: an open architecture to improve individual- and population-level health. J Med Internet Res. 2012 Aug 09; 14(4):e112. PMID: 22875563.
      View in: PubMed
    30. Boland MR, Tu SW, Carini S, Sim I, Weng C. EliXR-TIME: A Temporal Knowledge Representation for Clinical Research Eligibility Criteria. AMIA Jt Summits Transl Sci Proc. 2012; 2012:71-80. PMID: 22779055.
      View in: PubMed
    31. Ida Sim, Joyce C. Niland. Study Protocol Representation. Clinical Research Informatics. 2012 Jan 1; 155-174.
      View in: Publisher Site
    32. Susan Graham, Deborah Estrin, Eric Horvitz, Isaac Kohane, Elizabeth Mynatt, Ida Sim. Information Technology research challenges for healthcare: from discovery to delivery. ACM SIGHIT Record. 2011 Mar 1; 1(1):4-9.
      View in: Publisher Site
    33. Bhavnani SK, Carini S, Ross J, Sim I. Network analysis of clinical trials on depression: implications for comparative effectiveness research. AMIA Annu Symp Proc. 2010 Nov 13; 2010:51-5. PMID: 21346939.
      View in: PubMed
    34. Estrin D, Sim I. Health care delivery. Open mHealth architecture: an engine for health care innovation. Science. 2010 Nov 05; 330(6005):759-60. PMID: 21051617.
      View in: PubMed
    35. Kiritchenko S, de Bruijn B, Carini S, Martin J, Sim I. ExaCT: automatic extraction of clinical trial characteristics from journal publications. BMC Med Inform Decis Mak. 2010 Sep 28; 10:56. PMID: 20920176.
      View in: PubMed
    36. Tu SW, Peleg M, Carini S, Bobak M, Ross J, Rubin D, Sim I. A practical method for transforming free-text eligibility criteria into computable criteria. J Biomed Inform. 2011 Apr; 44(2):239-50. PMID: 20851207.
      View in: PubMed
    37. Ross J, Tu S, Carini S, Sim I. Analysis of eligibility criteria complexity in clinical trials. Summit Transl Bioinform. 2010 Mar 01; 2010:46-50. PMID: 21347148.
      View in: PubMed
    38. Wynden R, Weiner MG, Sim I, Gabriel D, Casale M, Carini S, Hastings S, Ervin D, Tu S, Gennari JH, Anderson N, Mobed K, Lakshminarayanan P, Massary M, Cucina RJ. Ontology mapping and data discovery for the translational investigator. Summit Transl Bioinform. 2010 Mar 01; 2010:66-70. PMID: 21347152.
      View in: PubMed
    39. Sim I, Carini S, Tu S, Wynden R, Pollock BH, Mollah SA, Gabriel D, Hagler HK, Scheuermann RH, Lehmann HP, Wittkowski KM, Nahm M, Bakken S. The human studies database project: federating human studies design data using the ontology of clinical research. Summit Transl Bioinform. 2010 Mar 01; 2010:51-5. PMID: 21347149.
      View in: PubMed
    40. Weng C, Tu SW, Sim I, Richesson R. Formal representation of eligibility criteria: a literature review. J Biomed Inform. 2010 Jun; 43(3):451-67. PMID: 20034594.
      View in: PubMed
    41. Carini S, Pollock BH, Lehmann HP, Bakken S, Barbour EM, Gabriel D, Hagler HK, Harper CR, Mollah SA, Nahm M, Nguyen HH, Scheuermann RH, Sim I. Development and evaluation of a study design typology for human research. AMIA Annu Symp Proc. 2009 Nov 14; 2009:81-5. PMID: 20351827.
      View in: PubMed
    42. Moja LP, Moschetti I, Nurbhai M, Compagnoni A, Liberati A, Grimshaw JM, Chan AW, Dickersin K, Krleza-Jeric K, Moher D, Sim I, Volmink J. Compliance of clinical trial registries with the World Health Organization minimum data set: a survey. Trials. 2009 Jul 22; 10:56. PMID: 19624821.
      View in: PubMed
    43. Bernstam EV, Hersh WR, Johnson SB, Chute CG, Nguyen H, Sim I, Nahm M, Weiner MG, Miller P, DiLaura RP, Overcash M, Lehmann HP, Eichmann D, Athey BD, Scheuermann RH, Anderson N, Starren J, Harris PA, Smith JW, Barbour E, Silverstein JC, Krusch DA, Nagarajan R, Becich MJ. Synergies and distinctions between computational disciplines in biomedical research: perspective from the Clinical andTranslational Science Award programs. Acad Med. 2009 Jul; 84(7):964-70. PMID: 19550198.
      View in: PubMed
    44. Bernstam EV, Hersh WR, Sim I, Eichmann D, Silverstein JC, Smith JW, Becich MJ. Unintended consequences of health information technology: a need for biomedical informatics. J Biomed Inform. 2010 Oct; 43(5):828-30. PMID: 19508898.
      View in: PubMed
    45. Sim I, Chute CG, Lehmann H, Nagarajan R, Nahm M, Scheuermann RH. Keeping raw data in context. Science. 2009 Feb 06; 323(5915):713. PMID: 19197039.
      View in: PubMed
    46. Karp PD, Sherlock G, Gerlt JA, Sim I, Paulsen I, Babbitt PC, Laderoute K, Hunter L, Sternberg P, Wooley J, Bourne PE. Changes to NIH grant system may backfire. Science. 2008 Nov 21; 322(5905):1187-8. PMID: 19023064.
      View in: PubMed
    47. Hernandez ME, Carini S, Storey MA, Sim I. An interactive tool for visualizing design heterogeneity in clinical trials. AMIA Annu Symp Proc. 2008 Nov 06; 298-302. PMID: 18998925.
      View in: PubMed
    48. Speedie SM, Taweel A, Sim I, Arvanitis TN, Arvanitis T, Delaney B, Peterson KA. Characterizing primary care research: PCROM versus BRIDG. AMIA Annu Symp Proc. 2008 Nov 06; 1145. PMID: 18998919.
      View in: PubMed
    49. de Bruijn B, Carini S, Kiritchenko S, Martin J, Sim I. Automated information extraction of key trial design elements from clinical trial publications. AMIA Annu Symp Proc. 2008 Nov 06; 141-5. PMID: 18999067.
      View in: PubMed
    50. Lee K, Bacchetti P, Sim I. Publication of clinical trials supporting successful new drug applications: a literature analysis. PLoS Med. 2008 Sep 23; 5(9):e191. PMID: 18816163.
      View in: PubMed
    51. Speedie SM, Taweel A, Sim I, Arvanitis TN, Delaney B, Peterson KA. The Primary Care Research Object Model (PCROM): a computable information model for practice-based primary care research. J Am Med Inform Assoc. 2008 Sep-Oct; 15(5):661-70. PMID: 18579829.
      View in: PubMed
    52. Ghersi D, Clarke M, Berlin J, Gülmezoglu A, Kush R, Lumbiganon P, Moher D, Rockhold F, Sim I, Wager E. Reporting the findings of clinical trials: a discussion paper. Bull World Health Organ. 2008 Jun; 86(6):492-3. PMID: 18568282.
      View in: PubMed
    53. Sim I. Trial registration for public trust: making the case for medical devices. J Gen Intern Med. 2008 Jan; 23 Suppl 1:64-8. PMID: 18095047.
      View in: PubMed
    54. Krleza-Jeric K, Chan AW, Dickersin K, Sim I, Grimshaw J, Gluud C. [Principles of the international registry of protocols and clinical trial results based on health interventions in human beings: Ottawa Declaration (part 1)]. Rev Panam Salud Publica. 2006 Jun; 19(6):413-6. PMID: 16968596.
      View in: PubMed
    55. Sim I, Chan AW, Gülmezoglu AM, Evans T, Pang T. Clinical trial registration: transparency is the watchword. Lancet. 2006 May 20; 367(9523):1631-3. PMID: 16714166.
      View in: PubMed
    56. Chan AW, Sim I, Gülmezoglu AM, Unterlerchner P, Karam G, Pang T. Assessing clinical trial results. Science. 2006 Apr 21; 312(5772):365-6; author reply 365-6. PMID: 16634140.
      View in: PubMed
    57. Gülmezoglu AM, Sim I. International clinical trial registration: any progress? Wien Klin Wochenschr. 2006 Feb; 118(1-2):1-2. PMID: 16489516.
      View in: PubMed
    58. Berlin A, Sorani M, Sim I. A taxonomic description of computer-based clinical decision support systems. J Biomed Inform. 2006 Dec; 39(6):656-67. PMID: 16442854.
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    59. Rubin DL, Lewis SE, Mungall CJ, Misra S, Westerfield M, Ashburner M, Sim I, Chute CG, Solbrig H, Storey MA, Smith B, Day-Richter J, Noy NF, Musen MA. National Center for Biomedical Ontology: advancing biomedicine through structured organization of scientific knowledge. OMICS. 2006; 10(2):185-98. PMID: 16901225.
      View in: PubMed
    60. Olasov B, Sim I. RuleEd, a web-based semantic network interface for constructing and revising computable eligibility rules. AMIA Annu Symp Proc. 2006; 1051. PMID: 17238670.
      View in: PubMed
    61. Sim I, Detmer DE. Beyond trial registration: a global trial bank for clinical trial reporting. PLoS Med. 2005 Nov; 2(11):e365. PMID: 16220999.
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    62. Miller RH, West C, Brown TM, Sim I, Ganchoff C. The value of electronic health records in solo or small group practices. Health Aff (Millwood). 2005 Sep-Oct; 24(5):1127-37. PMID: 16162555.
      View in: PubMed
    63. Krleza-Jeric K, Chan AW, Dickersin K, Sim I, Grimshaw J, Gluud C. Principles for international registration of protocol information and results from human trials of health related interventions: Ottawa statement (part 1). BMJ. 2005 Apr 23; 330(7497):956-8. PMID: 15845980.
      View in: PubMed
    64. Sim I, Cummings SR. Quantifying the gap between proof and practice. Evid Based Cardiovasc Med. 2004 Dec; 8(4):287-90. PMID: 16379955.
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    65. Sim I, Olasov B, Carini S. An ontology of randomized controlled trials for evidence-based practice: content specification and evaluation using the competency decomposition method. J Biomed Inform. 2004 Apr; 37(2):108-19. PMID: 15120657.
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    66. Miller RH, Sim I. Physicians' use of electronic medical records: barriers and solutions. Health Aff (Millwood). 2004 Mar-Apr; 23(2):116-26. PMID: 15046136.
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    67. Miller RH, Sim I, Newman J. Electronic medical records in solo/small groups: a qualitative study of physician user types. Stud Health Technol Inform. 2004; 107(Pt 1):658-62. PMID: 15360895.
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    68. Sim I, Carini S, Olasov B, Jeng S. Trial bank publishing: phase I results. Stud Health Technol Inform. 2004; 107(Pt 2):1476-80. PMID: 15361060.
      View in: PubMed
    69. Cuadros J, Sim I. EyePACS: an open source clinical communication system for eye care. Stud Health Technol Inform. 2004; 107(Pt 1):207-11. PMID: 15360804.
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    70. Berlin A, Sorani M, Sim I. Characteristics of outpatient clinical decision support systems: a taxonomic description. Stud Health Technol Inform. 2004; 107(Pt 1):578-81. PMID: 15360878.
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    71. Sim I, Cummings SR. A new framework for describing and quantifying the gap between proof and practice. Med Care. 2003 Aug; 41(8):874-81. PMID: 12886168.
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    72. Sim I, Berlin A. A framework for classifying decision support systems. AMIA Annu Symp Proc. 2003; 599-603. PMID: 14728243.
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    73. Sim I, Olasov B, Carini S. The Trial Bank system: capturing randomized trials for evidence-based medicine. AMIA Annu Symp Proc. 2003; 1076. PMID: 14728579.
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    74. Carini S, Sim I. SysBank: a knowledge base for systematic reviews of randomized clinical trials. AMIA Annu Symp Proc. 2003; 804. PMID: 14728309.
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    75. Sim I, Sanders GD, McDonald KM. Evidence-based practice for mere mortals: the role of informatics and health services research. J Gen Intern Med. 2002 Apr; 17(4):302-8. PMID: 11972727.
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    76. Linder JA, Sim I. Antibiotic treatment of acute bronchitis in smokers: a systematic review. J Gen Intern Med. 2002 Mar; 17(3):230-4. PMID: 11929510.
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    77. Sim I, Gorman P, Greenes RA, Haynes RB, Kaplan B, Lehmann H, Tang PC. Clinical decision support systems for the practice of evidence-based medicine. J Am Med Inform Assoc. 2001 Nov-Dec; 8(6):527-34. PMID: 11687560.
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    78. Sim I, Owens DK, Lavori PW, Rennels GD. Electronic trial banks: a complementary method for reporting randomized trials. Med Decis Making. 2000 Oct-Dec; 20(4):440-50. PMID: 11059477.
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    79. Sim I, Lavori P. Meta-analyses and large randomized, controlled trials. N Engl J Med. 1998 Jan 01; 338(1):61; author reply 61-2. PMID: 9424568.
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    80. Sim I, McDonald KM, Lavori PW, Norbutas CM, Hlatky MA. Quantitative overview of randomized trials of amiodarone to prevent sudden cardiac death. Circulation. 1997 Nov 04; 96(9):2823-9. PMID: 9386144.
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    81. Sim I, Hlatky MA. Growing pains of meta-analysis. BMJ. 1996 Sep 21; 313(7059):702-3. PMID: 8819428.
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    82. Ida Sim. S12 Standardized computer-based reporting of clinical trials: In support of meta-analysis. Contemporary Clinical Trials. 1996 Apr 1; 17(2):s44.
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    83. Sim I, Gupta M, McDonald K, Bourassa MG, Hlatky MA. A meta-analysis of randomized trials comparing coronary artery bypass grafting with percutaneous transluminal coronary angioplasty in multivessel coronary artery disease. Am J Cardiol. 1995 Nov 15; 76(14):1025-9. PMID: 7484855.
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    84. Pratt W, Sim I. Physician's information customizer (PIC): using a shareable user model to filter the medical literature. Medinfo. 1995; 8 Pt 2:1447-51. PMID: 8591472.
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    85. Sim I, Rennels G. A trial bank model for the publication of clinical trials. Proc Annu Symp Comput Appl Med Care. 1995; 863-7. PMID: 8563415.
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    86. Burcham TS, Sim I, Bolin LM, Shooter EM. The NGF complex from the African rat Mastomys natalensis. Neurochem Res. 1991 Jun; 16(6):603-12. PMID: 1791910.
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    87. Manchand PS, Cerruti RL, Martin JA, Hill CH, Merrett JH, Keech E, Belshe RB, Connell EV, Sim IS. Synthesis and antiviral activity of metabolites of rimantadine. J Med Chem. 1990 Jul; 33(7):1992-5. PMID: 2362279.
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    88. Lepock JR, Cheng KH, Al-Qysi H, Sim I, Koch CJ, Kruuv J. Hyperthermia-induced inhibition of respiration and mitochondrial protein denaturation in CHL cells. Int J Hyperthermia. 1987 Mar-Apr; 3(2):123-32. PMID: 3036971.
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    89. Frankfurt M, Siegel RA, Sim I, Wuttke W. Estrous cycle variations in cholecystokinin and substance P concentrations in discrete areas of the rat brain. Neuroendocrinology. 1986; 42(3):226-31. PMID: 2419781.
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    90. Frankfurt M, Siegel RA, Sim I, Wuttke W. Cholecystokinin and substance P concentrations in discrete areas of the rat brain: sex differences. Brain Res. 1985 Dec 09; 358(1-2):53-8. PMID: 2416392.
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