Irina Gitlin

Title(s)SR PROGRAM MANAGER, Cardiovascular Research Inst
SchoolSchool of Medicine
Address505 Parnassus Avenue
San Francisco CA 94117
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    Irina Gitlin, PhD, is a project manager for a drug development program in the laboratory of John V. Fahy; the project aims to bring to the clinic a novel mucolytic therapeutic agent to treat lung disease. Previously Irina was a Senior Program Manager in the Catalyst group at the Clinical and Translational Science Institute (CTSI) at UCSF, where she was responsible for management of campus-wide programs to facilitate translation of academic discoveries into valuable biomedical products. Prior to joining CTSI, Irina was a senior scientist at Arsenal Medical, an early stage medical device company in Boston area that specializes in bioresorbable polymer technologies. Her various roles in the company included leading the company's efforts in securing grants for technology development, managing the IP portfolio, and studying interactions of polymeric materials with cells and tissues. Irina earned her Ph.D. from the laboratory of George M. Whitesides in the Chemistry Department at Harvard University, working in the fields of protein biophysics and microfluidics.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Exploring antiviral and anti-inflammatory effects of thiol drugs in COVID-19. Am J Physiol Lung Cell Mol Physiol. 2022 09 01; 323(3):L372-L389. Khanna K, Raymond WW, Jin J, Charbit AR, Gitlin I, Tang M, Werts AD, Barrett EG, Cox JM, Birch SM, Martinelli R, Sperber HS, Franz S, Duff T, Hoffmann M, Healy AM, Oscarson S, Pöhlmann S, Pillai SK, Simmons G, Fahy JV. PMID: 35762590; PMCID: PMC9448286.
      View in: PubMed   Mentions:    Fields:    
    2. Mucus secretion blocked at its source in the lungs. Nature. 2022 03; 603(7903):798-799. Gitlin I, Fahy JV. PMID: 35322214.
      View in: PubMed   Mentions:    Fields:    
    3. Thiol drugs decrease SARS-CoV-2 lung injury in vivo and disrupt SARS-CoV-2 spike complex binding to ACE2 in vitro. bioRxiv. 2021 Nov 11. Khanna K, Raymond W, Jin J, Charbit AR, Gitlin I, Tang M, Werts AD, Barrett EG, Cox JM, Birch SM, Martinelli R, Sperber HS, Franz S, Pillai S, Healy AM, Duff T, Oscarson S, Hoffmann M, Pöhlmann S, Simmons G, Fahy JV. PMID: 33330868; PMCID: PMC7743076.
      View in: PubMed   Mentions:
    4. The use of hydrophobic amino acids in protecting spray dried trehalose formulations against moisture-induced changes. Eur J Pharm Biopharm. 2019 Nov; 144:139-153. Mah PT, O'Connell P, Focaroli S, Lundy R, O'Mahony TF, Hastedt JE, Gitlin I, Oscarson S, Fahy JV, Healy AM. PMID: 31536784; PMCID: PMC6938683.
      View in: PubMed   Mentions: 3     Fields:    
    5. Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding. Chem Rev. 2008 Mar; 108(3):946-1051. Krishnamurthy VM, Kaufman GK, Urbach AR, Gitlin I, Gudiksen KL, Weibel DB, Whitesides GM. PMID: 18335973; PMCID: PMC2740730.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansAnimalsCells
    6. Using ion channel-forming peptides to quantify protein-ligand interactions. J Am Chem Soc. 2008 Jan 30; 130(4):1453-65. Mayer M, Semetey V, Gitlin I, Yang J, Whitesides GM. PMID: 18179217; PMCID: PMC2692494.
      View in: PubMed   Mentions: 13     Fields:    
    7. Fabrication and Manipulation of Ionotropic Hydrogels Crosslinked by Paramagnetic Ions. Chem Mater. 2007; 19(6):1362-1368. Winkleman A, Bracher PJ, Gitlin I, Whitesides GM. PMID: 18802491; PMCID: PMC2542877.
      View in: PubMed   Mentions: 8  
    8. Effects of surface charge on denaturation of bovine carbonic anhydrase. Chembiochem. 2006 Aug; 7(8):1241-50. Gitlin I, Gudiksen KL, Whitesides GM. PMID: 16847847.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    9. Differentiation of proteins based on characteristic patterns of association and denaturation in solutions of SDS. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):7968-72. Gudiksen KL, Gitlin I, Whitesides GM. PMID: 16698920; PMCID: PMC1472413.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    10. Why are proteins charged? Networks of charge-charge interactions in proteins measured by charge ladders and capillary electrophoresis. Angew Chem Int Ed Engl. 2006 May 05; 45(19):3022-60. Gitlin I, Carbeck JD, Whitesides GM. PMID: 16619322.
      View in: PubMed   Mentions: 54     Fields:    Translation:Cells
    11. Increasing the net charge and decreasing the hydrophobicity of bovine carbonic anhydrase decreases the rate of denaturation with sodium dodecyl sulfate. Biophys J. 2006 Jul 01; 91(1):298-310. Gudiksen KL, Gitlin I, Moustakas DT, Whitesides GM. PMID: 16617087; PMCID: PMC1479075.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    12. Peracetylated bovine carbonic anhydrase (BCA-Ac18) is kinetically more stable than native BCA to sodium dodecyl sulfate. J Phys Chem B. 2006 Feb 09; 110(5):2372-7. Gitlin I, Gudiksen KL, Whitesides GM. PMID: 16471827.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    13. Eliminating positively charged lysine epsilon-NH3+ groups on the surface of carbonic anhydrase has no significant influence on its folding from sodium dodecyl sulfate. J Am Chem Soc. 2005 Apr 06; 127(13):4707-14. Gudiksen KL, Gitlin I, Yang J, Urbach AR, Moustakas DT, Whitesides GM. PMID: 15796537.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    14. Generation of monodisperse particles by using microfluidics: control over size, shape, and composition. Angew Chem Int Ed Engl. 2005 Jan 21; 44(5):724-8. Xu S, Nie Z, Seo M, Lewis P, Kumacheva E, Stone HA, Garstecki P, Weibel DB, Gitlin I, Whitesides GM. PMID: 15612064.
      View in: PubMed   Mentions: 111     Fields:    
    15. Influence of the Zn(II) cofactor on the refolding of bovine carbonic anhydrase after denaturation with sodium dodecyl sulfate. Anal Chem. 2004 Dec 15; 76(24):7151-61. Gudiksen KL, Urbach AR, Gitlin I, Yang J, Vazquez JA, Costello CE, Whitesides GM. PMID: 15595855.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    16. Micropatterned agarose gels for stamping arrays of proteins and gradients of proteins. Proteomics. 2004 Aug; 4(8):2366-76. Mayer M, Yang J, Gitlin I, Gracias DH, Whitesides GM. PMID: 15274132.
      View in: PubMed   Mentions: 17     Fields:    
    17. Synthesis of monodisperse polymers from proteins. J Am Chem Soc. 2003 Oct 15; 125(41):12392-3. Yang J, Gitlin I, Krishnamurthy VM, Vazquez JA, Costello CE, Whitesides GM. PMID: 14531666.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    18. Components for integrated poly(dimethylsiloxane) microfluidic systems. Electrophoresis. 2002 Oct; 23(20):3461-73. Ng JM, Gitlin I, Stroock AD, Whitesides GM. PMID: 12412113.
      View in: PubMed   Mentions: 71     Fields:    
    19. Analysis by capillary electrophoresis of the kinetics of charge ladder formation for bovine carbonic anhydrase. Anal Chem. 2002 Apr 15; 74(8):1870-8. Anderson JR, Chemiavskaya O, Gitlin I, Engel GS, Yuditsky L, Whitesides GM. PMID: 11985320.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
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