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Iryna Lobach, PhD

Title(s)Associate Professor, Epidemiology & Biostatistics
SchoolSchool of Medicine
Phone415-476-6115
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    Collapse Biography 
    Collapse Education and Training
    Texas A&M UniversityPhD2006Statistics
    Yale UniversityPostDoc in Statistical Genetics2008Public Health
    Collapse Awards and Honors
    The International Biometric Society2010Best Paper of the Year in Biometrics Journal

    Collapse Overview 
    Collapse Overview
    Dr. Iryna V. Lobach conducts research in applied statistics and supports the biostatistics component of biomedical research.

    Her methodological research interests are motivated by challenges arising in the analyses of how an effect of the genetic basis varies by non-genetic measures (environment), what is traditionally referred to as gene-environment interaction (GxE) analyses. This type of analyses might provide valuable clues to the underlying pathophysiologic mechanisms of complex phenotypes.

    For example, in collaboration with statisticians and biomedical researchers, Dr. Lobach developed an efficient retrospective analysis of case-control genetic studies in situations when the environmental variable is measured with error, e.g. diet or physical activity. Both in theory and in practice, this method improves efficiency of the risk parameter estimates and is capable of correcting coverage of 95% Confidence Intervals from e.g. 68% of the standard approach to the nominal 95% in a practical example of analyses of association between calcium intake and the risk of colorectal adenoma analyses.

    We developed statistical methods to incorporate heterogeneity of the clinical diagnosis characterized by biomarker studies in situations when 1) multiple distinct pathophysiologic mechanisms share symptoms and hence the clinical diagnosis; and 2) substantial segments of the population are undiagnosed. We show that the genetic variant will appear to interact with the environmental variable if the genetic variant affects the pathologically defined disease state and the environmental variable is related to the proportion of cases with that disease state. We then propose a pseudo-likelihood solution and apply the methods to large genome-wide studies of Prostate Cancer and Alzheimer’s disease.

    Recently, we developed case-only estimates of GxE in settings when 1) multiple disease state share the clinical diagnosis, 2) frequencies of the disease state of interest within the clinical diagnosis vary by the E or other variables, 3) both clinical diagnosis and the disease states are common. We show the application to Alzheimer's disease.

    We are also conducting studies to investigate bias in the genetic effect estimates due to omitting a continuous variable. Specifically, we are interested to assess what information is needed to correct the bias if the actual values of the continuous variable are not available to the researcher. For example, many of the genetic databases offer only a brief set of non-genetic variables. We show the application to Alzheimer's disease (https://www.biorxiv.org/content/10.1101/756015v1).

    We have recently studied whether a case-only study of GxE is better than a case-control study in the context when the disease state is common and when the multiple distinct disease states share a clinical diagnosis. We investigated differences in the GxE estimates in the context of Alzheimer's disease (https://www.biorxiv.org/content/10.1101/760322v1).

    Dr. Lobach supports the biostatistics component of multiple biomedical studies through collaboration, consultation (CTSI biostatistics consultant) and mentoring (K-grants, mentoring in the Training in Clinical Research Program).

    Collapse Research 
    Collapse Research Activities and Funding
    Role of the metabolic syndrome profile in genetic susceptibility to Alzheimer's d
    NIH/NIA R21AG043710May 15, 2014 - Apr 30, 2016
    Role: Principal Investigator
    Novel Analysis of Gene-Gene and Gene-Environment Interactions in Alcoholism
    NIH/NIAAA R21AA020356Sep 1, 2013 - Aug 31, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Lobach I, Sheng Y, Lobach S, Zablotska L, Huang CY. Case-control versus case-only estimates of gene-environment interactions with common and misclassified clinical diagnosis. Genet Epidemiol. 2019 Oct 30. PMID: 31667895.
      View in: PubMed
    2. Korenchan DE, Bok R, Sriram R, Liu K, Santos RD, Qin H, Lobach I, Korn N, Wilson DM, Kurhanewicz J, Flavell RR. Hyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer. Oncotarget. 2019 Oct 22; 10(58):6096-6110. PMID: 31692908.
      View in: PubMed
    3. Lobach I, Kim I, Alekseyenko A, Lobach S, Zhang L .A Simple Approximation to Bias in Gene–Environment Interaction Estimates When a Case Might Not Be the Case. Frontiers in Genetics. 2019.
    4. Lobach I, Kim I, Alekseyenko A, Lobach S, Zhang L. A Simple Approximation to Bias in Gene-Environment Interaction Estimates When a Case Might Not Be the Case. Front Genet. 2019; 10:886. PMID: 31681402.
      View in: PubMed
    5. Bucknor MD, Beroukhim G, Rieke V, Ozhinsky E, Lobach I. The impact of technical parameters on ablation volume during MR-guided focused ultrasound of desmoid tumors. Int J Hyperthermia. 2019; 36(1):473-476. PMID: 30922118.
      View in: PubMed
    6. Lobach I, Kim I, Alekseyenko A, Lobach S, Zhang L. A simple approximation to bias in the genetic effect estimates when multiple disease states share a clinical diagnosis. Genet Epidemiol. 2019 07; 43(5):522-531. PMID: 30888715.
      View in: PubMed
    7. Lobach I, Sampson J, Lobach S, Alekseyenko A, Piryatinska A, He T, Zhang L. A simple approximation to the bias of gene-environment interactions in case-control studies with silent disease. Genet Epidemiol. 2019 04; 43(3):292-299. PMID: 30623487.
      View in: PubMed
    8. Callen AL, Lobach I, Mesina O, Marcus S, Joe BN, Sickles EA, Greenwood HI. The Gambler's Fallacy in Screening Mammography. J Am Coll Radiol. 2019 Jun; 16(6):830-833. PMID: 30611683.
      View in: PubMed
    9. Korenchan DE, Bok R, Sriram R, Liu K, Santos RD, Qin H, Lobach I, Korn N, Wilson DM, Kurhanewicz J and Flavell RR.Hyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer. Oncotarget. 2019.
    10. Davis EJ, Lobach I, Dubal DB. Female XX sex chromosomes increase survival and extend lifespan in aging mice. Aging Cell. 2019 Feb; 18(1):e12871. PMID: 30560587.
      View in: PubMed
    11. Lobach I. Bias in parameter estimates due to omitting gene-environment interaction terms in case-control studies. Genet Epidemiol. 2018 12; 42(8):838-845. PMID: 30302820.
      View in: PubMed
    12. Lai YC, Ray KM, Lee AY, Hayward JH, Freimanis RI, Lobach IV, Joe BN. Microcalcifications Detected at Screening Mammography: Synthetic Mammography and Digital Breast Tomosynthesis versus Digital Mammography. Radiology. 2018 12; 289(3):630-638. PMID: 30277445.
      View in: PubMed
    13. Lobach I, Sampson J, Alekseyenko A, Lobach S, Zhang L. Case-control studies of gene-environment interactions. When a case might not be the case. PLoS One. 2018; 13(8):e0201140. PMID: 30133451.
      View in: PubMed
    14. Lobach I, Sampson J, Lobach S, Zhang L. Gene-environment interactions in case-control studies with silent disease. Genet Epidemiol. 2018 09; 42(6):551-558. PMID: 29896809.
      View in: PubMed
    15. Santos-Santos MA, Rabinovici GD, Iaccarino L, Ayakta N, Tammewar G, Lobach I, Henry ML, Hubbard I, Mandelli ML, Spinelli E, Miller ZA, Pressman PS, O'Neil JP, Ghosh P, Lazaris A, Meyer M, Watson C, Yoon SJ, Rosen HJ, Grinberg L, Seeley WW, Miller BL, Jagust WJ, Gorno-Tempini ML. Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia. JAMA Neurol. 2018 03 01; 75(3):342-352. PMID: 29309493.
      View in: PubMed
    16. Amano K, Huebner JL, Stabler TV, Tanaka M, McCulloch CE, Lobach I, Lane NE, Kraus VB, Ma CB, Li X. Synovial Fluid Profile at the Time of Anterior Cruciate Ligament Reconstruction and Its Association With Cartilage Matrix Composition 3 Years After Surgery. Am J Sports Med. 2018 03; 46(4):890-899. PMID: 29364702.
      View in: PubMed
    17. Rojas JC, Bang J, Lobach IV, Tsai RM, Rabinovici GD, Miller BL, Boxer AL. CSF neurofilament light chain and phosphorylated tau 181 predict disease progression in PSP. Neurology. 2018 01 23; 90(4):e273-e281. PMID: 29282336.
      View in: PubMed
    18. Ray KM, Kerlikowske K, Lobach IV, Hofmann MB, Greenwood HI, Arasu VA, Hylton NM, Joe BN. Effect of Background Parenchymal Enhancement on Breast MR Imaging Interpretive Performance in Community-based Practices. Radiology. 2018 03; 286(3):822-829. PMID: 29072981.
      View in: PubMed
    19. Greenwood HI, Lee AY, Lobach IV, Carpentier BM, Freimanis RI, Strachowski LM. Clustered Microcysts on Breast Ultrasound: What Is an Appropriate Management Recommendation? AJR Am J Roentgenol. 2017 Dec; 209(6):W395-W399. PMID: 28929806.
      View in: PubMed
    20. Goetzl EJ, Schwartz JB, Mustapic M, Lobach IV, Daneman R, Abner EL, Jicha GA. Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease. FASEB J. 2017 08; 31(8):3689-3694. PMID: 28476896.
      View in: PubMed
    21. Carey EJ, Lai JC, Wang CW, Dasarathy S, Lobach I, Montano-Loza AJ, Dunn MA. A multicenter study to define sarcopenia in patients with end-stage liver disease. Liver Transpl. 2017 05; 23(5):625-633. PMID: 28240805.
      View in: PubMed
    22. Woerman AL, Aoyagi A, Patel S, Kazmi SA, Lobach I, Grinberg LT, McKee AC, Seeley WW, Olson SH, Prusiner SB. Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):E8187-E8196. PMID: 27911827.
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    23. Bertoux M, Sarazin M, Pasquier F, Bottlaender M, de Souza LC, Mioshi E, Hornberger M, Ranasinghe KG, Rankin KP, Lobach IV, Kramer JH, Sturm VE, Bettcher BM, Possin K, You SC, Lamarre AK, Shany-Ur T, Stephens ML, Perry DC, Lee SE, Miller ZA, Gorno-Tempini ML, Rosen HJ, Boxer A, Seeley WW, Rabinovici GD, Vossel KA, Miller BL. Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage. Neurology. 2016 10 04; 87(14):1523. PMID: 27698154.
      View in: PubMed
    24. Heilmeier U, Hackl M, Skalicky S, Weilner S, Schroeder F, Vierlinger K, Patsch JM, Baum T, Oberbauer E, Lobach I, Burghardt AJ, Schwartz AV, Grillari J, Link TM. Serum miRNA Signatures Are Indicative of Skeletal Fractures in Postmenopausal Women With and Without Type 2 Diabetes and Influence Osteogenic and Adipogenic Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells In Vitro. J Bone Miner Res. 2016 12; 31(12):2173-2192. PMID: 27345526.
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    25. Goetzl EJ, Kapogiannis D, Schwartz JB, Lobach IV, Goetzl L, Abner EL, Jicha GA, Karydas AM, Boxer A, Miller BL. Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease. FASEB J. 2016 12; 30(12):4141-4148. PMID: 27601437.
      View in: PubMed
    26. Ranasinghe KG, Rankin KP, Pressman PS, Perry DC, Lobach IV, Seeley WW, Coppola G, Karydas AM, Grinberg LT, Shany-Ur T, Lee SE, Rabinovici GD, Rosen HJ, Gorno-Tempini ML, Boxer AL, Miller ZA, Chiong W, DeMay M, Kramer JH, Possin KL, Sturm VE, Bettcher BM, Neylan M, Zackey DD, Nguyen LA, Ketelle R, Block N, Wu TQ, Dallich A, Russek N, Caplan A, Geschwind DH, Vossel KA, Miller BL. Distinct Subtypes of Behavioral Variant Frontotemporal Dementia Based on Patterns of Network Degeneration. JAMA Neurol. 2016 Sep 01; 73(9):1078-88. PMID: 27429218.
      View in: PubMed
    27. Daud AI, Loo K, Pauli ML, Sanchez-Rodriguez R, Sandoval PM, Taravati K, Tsai K, Nosrati A, Nardo L, Alvarado MD, Algazi AP, Pampaloni MH, Lobach IV, Hwang J, Pierce RH, Gratz IK, Krummel MF, Rosenblum MD. Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma. J Clin Invest. 2016 09 01; 126(9):3447-52. PMID: 27525433.
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    28. Goetzl EJ, Mustapic M, Kapogiannis D, Eitan E, Lobach IV, Goetzl L, Schwartz JB, Miller BL. Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer's disease. FASEB J. 2016 11; 30(11):3853-3859. PMID: 27511944.
      View in: PubMed
    29. Roswell RO, Greet B, Shah S, Bernard S, Milin A, Lobach I, Guo Y, Radford MJ, Berger JS. Intravenous heparin dosing strategy in hospitalized patients with atrial dysrhythmias. J Thromb Thrombolysis. 2016 Aug; 42(2):179-85. PMID: 26951166.
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    30. Tsai RM, Lobach I, Bang J, Whitwell JL, Senjem ML, Jack CR, Rosen H, Miller B, Boxer AL. Clinical correlates of longitudinal brain atrophy in progressive supranuclear palsy. Parkinsonism Relat Disord. 2016 07; 28:29-35. PMID: 27132501.
      View in: PubMed
    31. Bang J, Lobach IV, Lang AE, Grossman M, Knopman DS, Miller BL, Schneider LS, Doody RS, Lees A, Gold M, Morimoto BH, Boxer AL. Predicting disease progression in progressive supranuclear palsy in multicenter clinical trials. Parkinsonism Relat Disord. 2016 07; 28:41-48. PMID: 27172829.
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    32. Stamelou M, Schöpe J, Wagenpfeil S, Del Ser T, Bang J, Lobach IY, Luong P, Respondek G, Oertel WH, Boxer A, Höglinger GU. Power calculations and placebo effect for future clinical trials in progressive supranuclear palsy. Mov Disord. 2016 05; 31(5):742-7. PMID: 26948290.
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    33. Smilowitz NR, Maduro GA, Lobach IV, Chen Y, Reynolds HR. Adverse Trends in Ischemic Heart Disease Mortality among Young New Yorkers, Particularly Young Black Women. PLoS One. 2016; 11(2):e0149015. PMID: 26882207.
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    34. Ranasinghe KG, Rankin KP, Lobach IV, Kramer JH, Sturm VE, Bettcher BM, Possin K, Christine You S, Lamarre AK, Shany-Ur T, Stephens ML, Perry DC, Lee SE, Miller ZA, Gorno-Tempini ML, Rosen HJ, Boxer A, Seeley WW, Rabinovici GD, Vossel KA, Miller BL. Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage. Neurology. 2016 Feb 16; 86(7):600-10. PMID: 26802093.
      View in: PubMed
    35. Caverzasi E, Hervey-Jumper SL, Jordan KM, Lobach IV, Li J, Panara V, Racine CA, Sankaranarayanan V, Amirbekian B, Papinutto N, Berger MS, Henry RG. Identifying preoperative language tracts and predicting postoperative functional recovery using HARDI q-ball fiber tractography in patients with gliomas. J Neurosurg. 2016 07; 125(1):33-45. PMID: 26654181.
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    36. Schlaeger R, Papinutto N, Zhu AH, Lobach IV, Bevan CJ, Bucci M, Castellano A, Gelfand JM, Graves JS, Green AJ, Jordan KM, Keshavan A, Panara V, Stern WA, von Büdingen HC, Waubant E, Goodin DS, Cree BA, Hauser SL, Henry RG. Association Between Thoracic Spinal Cord Gray Matter Atrophy and Disability in Multiple Sclerosis. JAMA Neurol. 2015 Aug; 72(8):897-904. PMID: 26053119.
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    37. Fan R, Wang Y, Boehnke M, Chen W, Li Y, Ren H, Lobach I, Xiong M. Gene Level Meta-Analysis of Quantitative Traits by Functional Linear Models. Genetics. 2015 Aug; 200(4):1089-104. PMID: 26058849.
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    38. Forner SA, Takada LT, Bettcher BM, Lobach IV, Tartaglia MC, Torres-Chae C, Haman A, Thai J, Vitali P, Neuhaus J, Bostrom A, Miller BL, Rosen HJ, Geschwind MD. Comparing CSF biomarkers and brain MRI in the diagnosis of sporadic Creutzfeldt-Jakob disease. Neurol Clin Pract. 2015 Apr; 5(2):116-125. PMID: 26137420.
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    39. Quinones A, Lobach I, Maduro GA, Smilowitz NR, Reynolds HR. Diabetes and ischemic heart disease death in people age 25-54: a multiple-cause-of-death analysis based on over 400?000 deaths from 1990 to 2008 in New York City. Clin Cardiol. 2015 Feb; 38(2):114-20. PMID: 25716311.
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    40. Caverzasi E, Mandelli ML, DeArmond SJ, Hess CP, Vitali P, Papinutto N, Oehler A, Miller BL, Lobach IV, Bastianello S, Geschwind MD, Henry RG. White matter involvement in sporadic Creutzfeldt-Jakob disease. Brain. 2014 Dec; 137(Pt 12):3339-54. PMID: 25367029.
      View in: PubMed
    41. Shah B, Burdowski J, Lobach I, Gianos E, Sedlis SP. A risk score for prediction of hyperglycemia at coronary angiography. JACC Cardiovasc Interv. 2014 Oct; 7(10):1199-201. PMID: 25240543.
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    42. Fan R, Wang Y, Mills JL, Carter TC, Lobach I, Wilson AF, Bailey-Wilson JE, Weeks DE, Xiong M. Generalized functional linear models for gene-based case-control association studies. Genet Epidemiol. 2014 Nov; 38(7):622-637. PMID: 25203683.
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    43. Bettcher BM, Watson CL, Walsh CM, Lobach IV, Neuhaus J, Miller JW, Green R, Patel N, Dutt S, Busovaca E, Rosen HJ, Yaffe K, Miller BL, Kramer JH. Interleukin-6, age, and corpus callosum integrity. PLoS One. 2014; 9(9):e106521. PMID: 25188448.
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    44. Schlaeger R, Papinutto N, Panara V, Bevan C, Lobach IV, Bucci M, Caverzasi E, Gelfand JM, Green AJ, Jordan KM, Stern WA, von Büdingen HC, Waubant E, Zhu AH, Goodin DS, Cree BA, Hauser SL, Henry RG. Spinal cord gray matter atrophy correlates with multiple sclerosis disability. Ann Neurol. 2014 Oct; 76(4):568-80. PMID: 25087920.
      View in: PubMed
    45. Mandelli ML, Caverzasi E, Binney RJ, Henry ML, Lobach I, Block N, Amirbekian B, Dronkers N, Miller BL, Henry RG, Gorno-Tempini ML. Frontal white matter tracts sustaining speech production in primary progressive aphasia. J Neurosci. 2014 Jul 16; 34(29):9754-67. PMID: 25031413.
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    46. Wagshal D, Sankaranarayanan S, Guss V, Hall T, Berisha F, Lobach I, Karydas A, Voltarelli L, Scherling C, Heuer H, Tartaglia MC, Miller Z, Coppola G, Ahlijanian M, Soares H, Kramer JH, Rabinovici GD, Rosen HJ, Miller BL, Meredith J, Boxer AL. Divergent CSF t alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 2015 Mar; 86(3):244-50. PMID: 24899730.
      View in: PubMed
    47. Boxer AL, Lang AE, Grossman M, Knopman DS, Miller BL, Schneider LS, Doody RS, Lees A, Golbe LI, Williams DR, Corvol JC, Ludolph A, Burn D, Lorenzl S, Litvan I, Roberson ED, Höglinger GU, Koestler M, Jack CR, Van Deerlin V, Randolph C, Lobach IV, Heuer HW, Gozes I, Parker L, Whitaker S, Hirman J, Stewart AJ, Gold M, Morimoto BH. Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial. Lancet Neurol. 2014 Jul; 13(7):676-85. PMID: 24873720.
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    48. Roswell RO, Greet B, Parikh P, Mignatti A, Freese J, Lobach I, Guo Y, Keller N, Radford M, Bangalore S. From door-to-balloon time to contact-to-device time: predictors of achieving target times in patients with ST-elevation myocardial infarction. Clin Cardiol. 2014 Jul; 37(7):389-94. PMID: 24700343.
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    49. Shah B, Berger JS, Amoroso NS, Mai X, Lorin JD, Danoff A, Schwartzbard AZ, Lobach I, Guo Y, Feit F, Slater J, Attubato MJ, Sedlis SP. Periprocedural glycemic control in patients with diabetes mellitus undergoing coronary angiography with possible percutaneous coronary intervention. Am J Cardiol. 2014 May 01; 113(9):1474-80. PMID: 24630791.
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    50. Caverzasi E, Henry RG, Vitali P, Lobach IV, Kornak J, Bastianello S, Dearmond SJ, Miller BL, Rosen HJ, Mandelli ML, Geschwind MD. Application of quantitative DTI metrics in sporadic CJD. Neuroimage Clin. 2014; 4:426-35. PMID: 24624328.
      View in: PubMed
    51. Lobach, I., Fan, R., Manga, P.Genotype-Based Association Mapping of Complex Diseases: Gene-Gene and Gene-Environment Interactions in Presence of Linkage Disequilibrium. Statistics and Its Interface. 2014; (7):51-60.
    52. Lobach I, Fan R, Manga P. Genotype-based association models of complex diseases to detect gene-gene and gene-environment interactions. Stat Interface. 2014; 7(1):51-60. PMID: 26191336.
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    53. Miller ZA, Mandelli ML, Rankin KP, Henry ML, Babiak MC, Frazier DT, Lobach IV, Bettcher BM, Wu TQ, Rabinovici GD, Graff-Radford NR, Miller BL, Gorno-Tempini ML. Handedness and language learning disability differentially distribute in progressive aphasia variants. Brain. 2013 Nov; 136(Pt 11):3461-73. PMID: 24056533.
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    54. Berger JS, Hochman J, Lobach I, Adelman MA, Riles TS, Rockman CB. Modifiable risk factor burden and the prevalence of peripheral artery disease in different vascular territories. J Vasc Surg. 2013 Sep; 58(3):673-81.e1. PMID: 23642926.
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    55. Thaipisuttikul P, Lobach I, Zweig Y, Gurnani A, Galvin JE. Capgras syndrome in Dementia with Lewy Bodies. Int Psychogeriatr. 2013 May; 25(5):843-9. PMID: 23211760.
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    56. Shah B, Oberweis B, Tummala L, Amoroso NS, Lobach I, Sedlis SP, Grossi E, Berger JS. Mean platelet volume and long-term mortality in patients undergoing percutaneous coronary intervention. Am J Cardiol. 2013 Jan 15; 111(2):185-9. PMID: 23102880.
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    57. Grossman E, Shelley D, Braithwaite RS, Lobach I, Goffin A, Rogers E, Sherman S. Effectiveness of smoking-cessation interventions for urban hospital patients: study protocol for a randomized controlled trial. Trials. 2012 Aug 01; 13:126. PMID: 22852878.
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    58. Miller LH, Toklu B, Rauch J, Lorin JD, Lobach I, Sedlis SP. Very long-term clinical follow-up after fractional flow reserve-guided coronary revascularization. J Invasive Cardiol. 2012 Jul; 24(7):309-15. PMID: 22781467.
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    59. Sarpel U, Ayo D, Lobach I, Xu R, Newman E. Inverse relationship between cirrhosis and massive tumours in hepatocellular carcinoma. HPB (Oxford). 2012 Nov; 14(11):741-5. PMID: 23043662.
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    60. Lobach I, Fan R. Genotype-Based Bayesian Analysis of Gene-Environment Interactions with Multiple Genetic Markers and Misclassification in Environmental Factors. J Probab Stat. 2012; 2012. PMID: 26180529.
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    61. Wan DW, Tzimas D, Smith JA, Kim S, Araujo J, David R, Lobach I, Sarpel U. Risk factors for early-onset and late-onset hepatocellular carcinoma in Asian immigrants with hepatitis B in the United States. Am J Gastroenterol. 2011 Nov; 106(11):1994-2000. PMID: 21912436.
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    62. Reynolds HR, Srichai MB, Iqbal SN, Slater JN, Mancini GB, Feit F, Pena-Sing I, Axel L, Attubato MJ, Yatskar L, Kalhorn RT, Wood DA, Lobach IV, Hochman JS. Mechanisms of myocardial infarction in women without angiographically obstructive coronary artery disease. Circulation. 2011 Sep 27; 124(13):1414-25. PMID: 21900087.
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    63. Bangalore S, Kumar S, Lobach I, Messerli FH. Blood pressure targets in subjects with type 2 diabetes mellitus/impaired fasting glucose: observations from traditional and bayesian random-effects meta-analyses of randomized trials. Circulation. 2011 Jun 21; 123(24):2799-810, 9 p following 810. PMID: 21632497.
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    64. Gany F, Dobslaw R, Ramirez J, Tonda J, Lobach I, Leng J. Mexican urban occupational health in the US: a population at risk. J Community Health. 2011 Apr; 36(2):175-9. PMID: 20614170.
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    65. Carrier E, McNeely J, Lobach I, Tay S, Gourevitch MN, Raven MC. Factors associated with frequent utilization of crisis substance use detoxification services. J Addict Dis. 2011 Apr; 30(2):116-22. PMID: 21491293.
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    66. Gany F, Ramirez J, Nierodzick ML, McNish T, Lobach I, Leng J. Cancer portal project: a multidisciplinary approach to cancer care among Hispanic patients. J Oncol Pract. 2011 Jan; 7(1):31-8. PMID: 21532808.
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    67. Lobach I, Mallick B, Carroll RJ. Semiparametric Bayesian analysis of gene-environment interactions with error in measurement of environmental covariates and missing genetic data. Stat Interface. 2011; 4(3):305-316. PMID: 21949562.
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    68. Lobach I, Fan R, Carroll RJ. Genotype-based association mapping of complex diseases: gene-environment interactions with multiple genetic markers and measurement error in environmental exposures. Genet Epidemiol. 2010 Dec; 34(8):792-802. PMID: 21031455.
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    69. Reynolds HR, Steckman DA, Tunick PA, Kronzon I, Lobach I, Rosenzweig BP. Normal intima-media thickness on carotid ultrasound reliably excludes an ischemic cause of cardiomyopathy. Am Heart J. 2010 Jun; 159(6):1059-66. PMID: 20569720.
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    70. Lobach I, Carroll RJ, Spinka C, Gail MH, Chatterjee N. Haplotype-based regression analysis and inference of case-control studies with unphased genotypes and measurement errors in environmental exposures. Biometrics. 2008 Sep; 64(3):673-84. PMID: 18047538.
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    71. Lobach, I and Fan, R.Genotype-based Bayesian Analysis of Gene-Environment Interactions with Multiple Genetic Markers and Misclassification in Environmental Factors. Journal of Probability and Statistics. 2012.