Loading...

Iryna Lobach, PhD

Title(s)Associate Professor, Epidemiology & Biostatistics
SchoolSchool of Medicine
Phone415-476-6115
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Texas A&M UniversityPhD2006Statistics
    Yale UniversityPostDoc in Statistical Genetics2008Public Health
    Collapse Awards and Honors
    The International Biometric Society2010Best Paper of the Year in Biometrics Journal

    Collapse Overview 
    Collapse Overview
    Dr. Iryna V. Lobach conducts research in applied statistics and supports the biostatistics component of biomedical research.

    Her methodological research interests are motivated by challenges arising in the analyses of how an effect of the genetic basis varies by non-genetic measures (environment), what is traditionally referred to as gene-environment interaction (GxE) analyses. This type of analyses might provide valuable clues to the underlying pathophysiologic mechanisms of complex phenotypes.

    For example, in collaboration with statisticians and biomedical researchers, Dr. Lobach developed an efficient retrospective analysis of case-control genetic studies in situations when the environmental variable is measured with error, e.g. diet or physical activity. Both in theory and in practice, this method improves efficiency of the risk parameter estimates and is capable of correcting coverage of 95% Confidence Intervals from e.g. 68% of the standard approach to the nominal 95% in a practical example of analyses of association between calcium intake and the risk of colorectal adenoma analyses.

    We developed statistical methods to incorporate heterogeneity of the clinical diagnosis characterized by biomarker studies in situations when 1) multiple distinct pathophysiologic mechanisms share symptoms and hence the clinical diagnosis; and 2) substantial segments of the population are undiagnosed. We show that the genetic variant will appear to interact with the environmental variable if the genetic variant affects the pathologically defined disease state and the environmental variable is related to the proportion of cases with that disease state. We then propose a pseudo-likelihood solution and apply the methods to large genome-wide studies of Prostate Cancer and Alzheimer’s disease.

    Recently, we developed case-only estimates of GxE in settings when 1) multiple disease state share the clinical diagnosis, 2) frequencies of the disease state of interest within the clinical diagnosis vary by the E or other variables, 3) both clinical diagnosis and the disease states are common. We show the application to Alzheimer's disease.

    We are also conducting studies to investigate bias in the genetic effect estimates due to omitting a continuous variable. Specifically, we are interested to assess what information is needed to correct the bias if the actual values of the continuous variable are not available to the researcher. For example, many of the genetic databases offer only a brief set of non-genetic variables. We show the application to Alzheimer's disease (https://www.biorxiv.org/content/10.1101/756015v1).

    We have recently studied whether a case-only study of GxE is better than a case-control study in the context when the disease state is common and when the multiple distinct disease states share a clinical diagnosis. We investigated differences in the GxE estimates in the context of Alzheimer's disease (https://www.biorxiv.org/content/10.1101/760322v1).

    Dr. Lobach supports the biostatistics component of multiple biomedical studies through collaboration, consultation (CTSI biostatistics consultant) and mentoring (K-grants, mentoring in the Training in Clinical Research Program).

    Collapse Research 
    Collapse Research Activities and Funding
    Role of the metabolic syndrome profile in genetic susceptibility to Alzheimer's d
    NIH/NIA R21AG043710May 15, 2014 - Apr 30, 2016
    Role: Principal Investigator
    Novel Analysis of Gene-Gene and Gene-Environment Interactions in Alcoholism
    NIH/NIAAA R21AA020356Sep 1, 2013 - Aug 31, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pericardial Fat Enhancement: New Computed Tomography Biomarker Influences the Relationship Between Pericardial Fat and Coronary Artery Disease. J Thorac Imaging. 2020 Jul; 35(4):270-275. Kallianos KG, Lorca MC, Moraes GL, Devcic Z, Lobach I, Ordovas KG. PMID: 31913256.
      View in: PubMed   Mentions:    Fields:    
    2. Performance of screening MRI in high risk patients at initial versus subsequent screen. Clin Imaging. 2020 May 16; 66:87-92. Hayward JH, Ray KM, Price ER, Sickles EA, Conlon K, Lobach I, Joe BN, Lee AY. PMID: 32460153.
      View in: PubMed   Mentions:    Fields:    
    3. Factors predicting metastatic disease in 68Ga-PSMA-11 PET positive osseous lesions in prostate cancer. J Nucl Med. 2020 Apr 17. Chiu LW, Lawhn-Heath C, Behr S, Juarez R, Perez PM, Lobach I, Bucknor MD, Hope TA, Flavell RR. PMID: 32303599.
      View in: PubMed   Mentions:    Fields:    
    4. Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development. Neuron. 2020 May 06; 106(3):404-420.e8. Lennox AL, Hoye ML, Jiang R, Johnson-Kerner BL, Suit LA, Venkataramanan S, Sheehan CJ, Alsina FC, Fregeau B, Aldinger KA, Moey C, Lobach I, Afenjar A, Babovic-Vuksanovic D, Bézieau S, Blackburn PR, Bunt J, Burglen L, Campeau PM, Charles P, Chung BHY, Cogné B, Curry C, D'Agostino MD, Di Donato N, Faivre L, Héron D, Innes AM, Isidor B, Keren B, Kimball A, Klee EW, Kuentz P, Küry S, Martin-Coignard D, Mirzaa G, Mignot C, Miyake N, Matsumoto N, Fujita A, Nava C, Nizon M, Rodriguez D, Blok LS, Thauvin-Robinet C, Thevenon J, Vincent M, Ziegler A, Dobyns W, Richards LJ, Barkovich AJ, Floor SN, Silver DL, Sherr EH. PMID: 32135084.
      View in: PubMed   Mentions:    Fields:    
    5. Case-control versus case-only estimates of gene-environment interactions with common and misclassified clinical diagnosis. Genet Epidemiol. 2020 01; 44(1):4-15. Lobach I, Sheng Y, Lobach S, Zablotska L, Huang CY. PMID: 31667895.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Hyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer. Oncotarget. 2019 Oct 22; 10(58):6096-6110. Korenchan DE, Bok R, Sriram R, Liu K, Santos RD, Qin H, Lobach I, Korn N, Wilson DM, Kurhanewicz J, Flavell RR. PMID: 31692908.
      View in: PubMed   Mentions:    Fields:    
    7. A Simple Approximation to Bias in Gene-Environment Interaction Estimates When a Case Might Not Be the Case. Front Genet. 2019; 10:886. Lobach I, Kim I, Alekseyenko A, Lobach S, Zhang L. PMID: 31681402.
      View in: PubMed   Mentions:
    8. The impact of technical parameters on ablation volume during MR-guided focused ultrasound of desmoid tumors. Int J Hyperthermia. 2019; 36(1):473-476. Bucknor MD, Beroukhim G, Rieke V, Ozhinsky E, Lobach I. PMID: 30922118.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. A simple approximation to bias in the genetic effect estimates when multiple disease states share a clinical diagnosis. Genet Epidemiol. 2019 07; 43(5):522-531. Lobach I, Kim I, Alekseyenko A, Lobach S, Zhang L. PMID: 30888715.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. A simple approximation to the bias of gene-environment interactions in case-control studies with silent disease. Genet Epidemiol. 2019 04; 43(3):292-299. Lobach I, Sampson J, Lobach S, Alekseyenko A, Piryatinska A, He T, Zhang L. PMID: 30623487.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. The Gambler's Fallacy in Screening Mammography. J Am Coll Radiol. 2019 Jun; 16(6):830-833. Callen AL, Lobach I, Mesina O, Marcus S, Joe BN, Sickles EA, Greenwood HI. PMID: 30611683.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Female XX sex chromosomes increase survival and extend lifespan in aging mice. Aging Cell. 2019 02; 18(1):e12871. Davis EJ, Lobach I, Dubal DB. PMID: 30560587.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    13. Bias in parameter estimates due to omitting gene-environment interaction terms in case-control studies. Genet Epidemiol. 2018 12; 42(8):838-845. Lobach I. PMID: 30302820.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Microcalcifications Detected at Screening Mammography: Synthetic Mammography and Digital Breast Tomosynthesis versus Digital Mammography. Radiology. 2018 12; 289(3):630-638. Lai YC, Ray KM, Lee AY, Hayward JH, Freimanis RI, Lobach IV, Joe BN. PMID: 30277445.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Case-control studies of gene-environment interactions. When a case might not be the case. PLoS One. 2018; 13(8):e0201140. Lobach I, Sampson J, Alekseyenko A, Lobach S, Zhang L. PMID: 30133451.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Gene-environment interactions in case-control studies with silent disease. Genet Epidemiol. 2018 09; 42(6):551-558. Lobach I, Sampson J, Lobach S, Zhang L. PMID: 29896809.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia. JAMA Neurol. 2018 03 01; 75(3):342-352. Santos-Santos MA, Rabinovici GD, Iaccarino L, Ayakta N, Tammewar G, Lobach I, Henry ML, Hubbard I, Mandelli ML, Spinelli E, Miller ZA, Pressman PS, O'Neil JP, Ghosh P, Lazaris A, Meyer M, Watson C, Yoon SJ, Rosen HJ, Grinberg L, Seeley WW, Miller BL, Jagust WJ, Gorno-Tempini ML. PMID: 29309493.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    18. Synovial Fluid Profile at the Time of Anterior Cruciate Ligament Reconstruction and Its Association With Cartilage Matrix Composition 3 Years After Surgery. Am J Sports Med. 2018 03; 46(4):890-899. Amano K, Huebner JL, Stabler TV, Tanaka M, McCulloch CE, Lobach I, Lane NE, Kraus VB, Ma CB, Li X. PMID: 29364702.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. CSF neurofilament light chain and phosphorylated tau 181 predict disease progression in PSP. Neurology. 2018 01 23; 90(4):e273-e281. Rojas JC, Bang J, Lobach IV, Tsai RM, Rabinovici GD, Miller BL, Boxer AL. PMID: 29282336.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCellsCTClinical Trials
    20. Effect of Background Parenchymal Enhancement on Breast MR Imaging Interpretive Performance in Community-based Practices. Radiology. 2018 03; 286(3):822-829. Ray KM, Kerlikowske K, Lobach IV, Hofmann MB, Greenwood HI, Arasu VA, Hylton NM, Joe BN. PMID: 29072981.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    21. Clustered Microcysts on Breast Ultrasound: What Is an Appropriate Management Recommendation? AJR Am J Roentgenol. 2017 Dec; 209(6):W395-W399. Greenwood HI, Lee AY, Lobach IV, Carpentier BM, Freimanis RI, Strachowski LM. PMID: 28929806.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease. FASEB J. 2017 08; 31(8):3689-3694. Goetzl EJ, Schwartz JB, Mustapic M, Lobach IV, Daneman R, Abner EL, Jicha GA. PMID: 28476896.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    23. A multicenter study to define sarcopenia in patients with end-stage liver disease. Liver Transpl. 2017 05; 23(5):625-633. Carey EJ, Lai JC, Wang CW, Dasarathy S, Lobach I, Montano-Loza AJ, Dunn MA. PMID: 28240805.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    24. Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):E8187-E8196. Woerman AL, Aoyagi A, Patel S, Kazmi SA, Lobach I, Grinberg LT, McKee AC, Seeley WW, Olson SH, Prusiner SB. PMID: 27911827.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    25. Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage. Neurology. 2016 10 04; 87(14):1523. Bertoux M, Sarazin M, Pasquier F, Bottlaender M, de Souza LC, Mioshi E, Hornberger M, Ranasinghe KG, Rankin KP, Lobach IV, Kramer JH, Sturm VE, Bettcher BM, Possin K, You SC, Lamarre AK, Shany-Ur T, Stephens ML, Perry DC, Lee SE, Miller ZA, Gorno-Tempini ML, Rosen HJ, Boxer A, Seeley WW, Rabinovici GD, Vossel KA, Miller BL. PMID: 27698154.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Serum miRNA Signatures Are Indicative of Skeletal Fractures in Postmenopausal Women With and Without Type 2 Diabetes and Influence Osteogenic and Adipogenic Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells In Vitro. J Bone Miner Res. 2016 12; 31(12):2173-2192. Heilmeier U, Hackl M, Skalicky S, Weilner S, Schroeder F, Vierlinger K, Patsch JM, Baum T, Oberbauer E, Lobach I, Burghardt AJ, Schwartz AV, Grillari J, Link TM. PMID: 27345526.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    27. Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease. FASEB J. 2016 12; 30(12):4141-4148. Goetzl EJ, Kapogiannis D, Schwartz JB, Lobach IV, Goetzl L, Abner EL, Jicha GA, Karydas AM, Boxer A, Miller BL. PMID: 27601437.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    28. Distinct Subtypes of Behavioral Variant Frontotemporal Dementia Based on Patterns of Network Degeneration. JAMA Neurol. 2016 Sep 01; 73(9):1078-88. Ranasinghe KG, Rankin KP, Pressman PS, Perry DC, Lobach IV, Seeley WW, Coppola G, Karydas AM, Grinberg LT, Shany-Ur T, Lee SE, Rabinovici GD, Rosen HJ, Gorno-Tempini ML, Boxer AL, Miller ZA, Chiong W, DeMay M, Kramer JH, Possin KL, Sturm VE, Bettcher BM, Neylan M, Zackey DD, Nguyen LA, Ketelle R, Block N, Wu TQ, Dallich A, Russek N, Caplan A, Geschwind DH, Vossel KA, Miller BL. PMID: 27429218.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    29. Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma. J Clin Invest. 2016 09 01; 126(9):3447-52. Daud AI, Loo K, Pauli ML, Sanchez-Rodriguez R, Sandoval PM, Taravati K, Tsai K, Nosrati A, Nardo L, Alvarado MD, Algazi AP, Pampaloni MH, Lobach IV, Hwang J, Pierce RH, Gratz IK, Krummel MF, Rosenblum MD. PMID: 27525433.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    30. Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer's disease. FASEB J. 2016 11; 30(11):3853-3859. Goetzl EJ, Mustapic M, Kapogiannis D, Eitan E, Lobach IV, Goetzl L, Schwartz JB, Miller BL. PMID: 27511944.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    31. Intravenous heparin dosing strategy in hospitalized patients with atrial dysrhythmias. J Thromb Thrombolysis. 2016 Aug; 42(2):179-85. Roswell RO, Greet B, Shah S, Bernard S, Milin A, Lobach I, Guo Y, Radford MJ, Berger JS. PMID: 26951166.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. Clinical correlates of longitudinal brain atrophy in progressive supranuclear palsy. Parkinsonism Relat Disord. 2016 07; 28:29-35. Tsai RM, Lobach I, Bang J, Whitwell JL, Senjem ML, Jack CR, Rosen H, Miller B, Boxer AL. PMID: 27132501.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    33. Predicting disease progression in progressive supranuclear palsy in multicenter clinical trials. Parkinsonism Relat Disord. 2016 07; 28:41-48. Bang J, Lobach IV, Lang AE, Grossman M, Knopman DS, Miller BL, Schneider LS, Doody RS, Lees A, Gold M, Morimoto BH, Boxer AL. PMID: 27172829.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    34. Power calculations and placebo effect for future clinical trials in progressive supranuclear palsy. Mov Disord. 2016 05; 31(5):742-7. Stamelou M, Schöpe J, Wagenpfeil S, Del Ser T, Bang J, Lobach IY, Luong P, Respondek G, Oertel WH, Boxer A, Höglinger GU. PMID: 26948290.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    35. Adverse Trends in Ischemic Heart Disease Mortality among Young New Yorkers, Particularly Young Black Women. PLoS One. 2016; 11(2):e0149015. Smilowitz NR, Maduro GA, Lobach IV, Chen Y, Reynolds HR. PMID: 26882207.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    36. Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage. Neurology. 2016 Feb 16; 86(7):600-10. Ranasinghe KG, Rankin KP, Lobach IV, Kramer JH, Sturm VE, Bettcher BM, Possin K, Christine You S, Lamarre AK, Shany-Ur T, Stephens ML, Perry DC, Lee SE, Miller ZA, Gorno-Tempini ML, Rosen HJ, Boxer A, Seeley WW, Rabinovici GD, Vossel KA, Miller BL. PMID: 26802093.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    37. Identifying preoperative language tracts and predicting postoperative functional recovery using HARDI q-ball fiber tractography in patients with gliomas. J Neurosurg. 2016 07; 125(1):33-45. Caverzasi E, Hervey-Jumper SL, Jordan KM, Lobach IV, Li J, Panara V, Racine CA, Sankaranarayanan V, Amirbekian B, Papinutto N, Berger MS, Henry RG. PMID: 26654181.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    38. Association Between Thoracic Spinal Cord Gray Matter Atrophy and Disability in Multiple Sclerosis. JAMA Neurol. 2015 Aug; 72(8):897-904. Schlaeger R, Papinutto N, Zhu AH, Lobach IV, Bevan CJ, Bucci M, Castellano A, Gelfand JM, Graves JS, Green AJ, Jordan KM, Keshavan A, Panara V, Stern WA, von Büdingen HC, Waubant E, Goodin DS, Cree BA, Hauser SL, Henry RG. PMID: 26053119.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    39. Gene Level Meta-Analysis of Quantitative Traits by Functional Linear Models. Genetics. 2015 Aug; 200(4):1089-104. Fan R, Wang Y, Boehnke M, Chen W, Li Y, Ren H, Lobach I, Xiong M. PMID: 26058849.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    40. Comparing CSF biomarkers and brain MRI in the diagnosis of sporadic Creutzfeldt-Jakob disease. Neurol Clin Pract. 2015 Apr; 5(2):116-125. Forner SA, Takada LT, Bettcher BM, Lobach IV, Tartaglia MC, Torres-Chae C, Haman A, Thai J, Vitali P, Neuhaus J, Bostrom A, Miller BL, Rosen HJ, Geschwind MD. PMID: 26137420.
      View in: PubMed   Mentions:
    41. Diabetes and ischemic heart disease death in people age 25-54: a multiple-cause-of-death analysis based on over 400?000 deaths from 1990 to 2008 in New York City. Clin Cardiol. 2015 Feb; 38(2):114-20. Quinones A, Lobach I, Maduro GA, Smilowitz NR, Reynolds HR. PMID: 25716311.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. White matter involvement in sporadic Creutzfeldt-Jakob disease. Brain. 2014 Dec; 137(Pt 12):3339-54. Caverzasi E, Mandelli ML, DeArmond SJ, Hess CP, Vitali P, Papinutto N, Oehler A, Miller BL, Lobach IV, Bastianello S, Geschwind MD, Henry RG. PMID: 25367029.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    43. A risk score for prediction of hyperglycemia at coronary angiography. JACC Cardiovasc Interv. 2014 Oct; 7(10):1199-201. Shah B, Burdowski J, Lobach I, Gianos E, Sedlis SP. PMID: 25240543.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    44. Generalized functional linear models for gene-based case-control association studies. Genet Epidemiol. 2014 Nov; 38(7):622-637. Fan R, Wang Y, Mills JL, Carter TC, Lobach I, Wilson AF, Bailey-Wilson JE, Weeks DE, Xiong M. PMID: 25203683.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    45. Interleukin-6, age, and corpus callosum integrity. PLoS One. 2014; 9(9):e106521. Bettcher BM, Watson CL, Walsh CM, Lobach IV, Neuhaus J, Miller JW, Green R, Patel N, Dutt S, Busovaca E, Rosen HJ, Yaffe K, Miller BL, Kramer JH. PMID: 25188448.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    46. Spinal cord gray matter atrophy correlates with multiple sclerosis disability. Ann Neurol. 2014 Oct; 76(4):568-80. Schlaeger R, Papinutto N, Panara V, Bevan C, Lobach IV, Bucci M, Caverzasi E, Gelfand JM, Green AJ, Jordan KM, Stern WA, von Büdingen HC, Waubant E, Zhu AH, Goodin DS, Cree BA, Hauser SL, Henry RG. PMID: 25087920.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    47. Frontal white matter tracts sustaining speech production in primary progressive aphasia. J Neurosci. 2014 Jul 16; 34(29):9754-67. Mandelli ML, Caverzasi E, Binney RJ, Henry ML, Lobach I, Block N, Amirbekian B, Dronkers N, Miller BL, Henry RG, Gorno-Tempini ML. PMID: 25031413.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    48. Divergent CSF t alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 2015 Mar; 86(3):244-50. Wagshal D, Sankaranarayanan S, Guss V, Hall T, Berisha F, Lobach I, Karydas A, Voltarelli L, Scherling C, Heuer H, Tartaglia MC, Miller Z, Coppola G, Ahlijanian M, Soares H, Kramer JH, Rabinovici GD, Rosen HJ, Miller BL, Meredith J, Boxer AL. PMID: 24899730.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    49. Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial. Lancet Neurol. 2014 Jul; 13(7):676-85. Boxer AL, Lang AE, Grossman M, Knopman DS, Miller BL, Schneider LS, Doody RS, Lees A, Golbe LI, Williams DR, Corvol JC, Ludolph A, Burn D, Lorenzl S, Litvan I, Roberson ED, Höglinger GU, Koestler M, Jack CR, Van Deerlin V, Randolph C, Lobach IV, Heuer HW, Gozes I, Parker L, Whitaker S, Hirman J, Stewart AJ, Gold M, Morimoto BH. PMID: 24873720.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCTClinical Trials
    50. From door-to-balloon time to contact-to-device time: predictors of achieving target times in patients with ST-elevation myocardial infarction. Clin Cardiol. 2014 Jul; 37(7):389-94. Roswell RO, Greet B, Parikh P, Mignatti A, Freese J, Lobach I, Guo Y, Keller N, Radford M, Bangalore S. PMID: 24700343.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    51. Periprocedural glycemic control in patients with diabetes mellitus undergoing coronary angiography with possible percutaneous coronary intervention. Am J Cardiol. 2014 May 01; 113(9):1474-80. Shah B, Berger JS, Amoroso NS, Mai X, Lorin JD, Danoff A, Schwartzbard AZ, Lobach I, Guo Y, Feit F, Slater J, Attubato MJ, Sedlis SP. PMID: 24630791.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    52. Application of quantitative DTI metrics in sporadic CJD. Neuroimage Clin. 2014; 4:426-35. Caverzasi E, Henry RG, Vitali P, Lobach IV, Kornak J, Bastianello S, Dearmond SJ, Miller BL, Rosen HJ, Mandelli ML, Geschwind MD. PMID: 24624328.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    53. Genotype-Based Association Mapping of Complex Diseases: Gene-Gene and Gene-Environment Interactions in Presence of Linkage Disequilibrium. Statistics and Its Interface. 2014; (7):51-60. Lobach, I., Fan, R., Manga, P.
    54. Genotype-based association models of complex diseases to detect gene-gene and gene-environment interactions. Stat Interface. 2014; 7(1):51-60. Lobach I, Fan R, Manga P. PMID: 26191336.
      View in: PubMed   Mentions:
    55. Handedness and language learning disability differentially distribute in progressive aphasia variants. Brain. 2013 Nov; 136(Pt 11):3461-73. Miller ZA, Mandelli ML, Rankin KP, Henry ML, Babiak MC, Frazier DT, Lobach IV, Bettcher BM, Wu TQ, Rabinovici GD, Graff-Radford NR, Miller BL, Gorno-Tempini ML. PMID: 24056533.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    56. Modifiable risk factor burden and the prevalence of peripheral artery disease in different vascular territories. J Vasc Surg. 2013 Sep; 58(3):673-81.e1. Berger JS, Hochman J, Lobach I, Adelman MA, Riles TS, Rockman CB. PMID: 23642926.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    57. Capgras syndrome in Dementia with Lewy Bodies. Int Psychogeriatr. 2013 May; 25(5):843-9. Thaipisuttikul P, Lobach I, Zweig Y, Gurnani A, Galvin JE. PMID: 23211760.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    58. Mean platelet volume and long-term mortality in patients undergoing percutaneous coronary intervention. Am J Cardiol. 2013 Jan 15; 111(2):185-9. Shah B, Oberweis B, Tummala L, Amoroso NS, Lobach I, Sedlis SP, Grossi E, Berger JS. PMID: 23102880.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    59. Effectiveness of smoking-cessation interventions for urban hospital patients: study protocol for a randomized controlled trial. Trials. 2012 Aug 01; 13:126. Grossman E, Shelley D, Braithwaite RS, Lobach I, Goffin A, Rogers E, Sherman S. PMID: 22852878.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    60. Very long-term clinical follow-up after fractional flow reserve-guided coronary revascularization. J Invasive Cardiol. 2012 Jul; 24(7):309-15. Miller LH, Toklu B, Rauch J, Lorin JD, Lobach I, Sedlis SP. PMID: 22781467.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    61. Inverse relationship between cirrhosis and massive tumours in hepatocellular carcinoma. HPB (Oxford). 2012 Nov; 14(11):741-5. Sarpel U, Ayo D, Lobach I, Xu R, Newman E. PMID: 23043662.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    62. Genotype-Based Bayesian Analysis of Gene-Environment Interactions with Multiple Genetic Markers and Misclassification in Environmental Factors. J Probab Stat. 2012; 2012. Lobach I, Fan R. PMID: 26180529.
      View in: PubMed   Mentions:
    63. Risk factors for early-onset and late-onset hepatocellular carcinoma in Asian immigrants with hepatitis B in the United States. Am J Gastroenterol. 2011 Nov; 106(11):1994-2000. Wan DW, Tzimas D, Smith JA, Kim S, Araujo J, David R, Lobach I, Sarpel U. PMID: 21912436.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    64. Mechanisms of myocardial infarction in women without angiographically obstructive coronary artery disease. Circulation. 2011 Sep 27; 124(13):1414-25. Reynolds HR, Srichai MB, Iqbal SN, Slater JN, Mancini GB, Feit F, Pena-Sing I, Axel L, Attubato MJ, Yatskar L, Kalhorn RT, Wood DA, Lobach IV, Hochman JS. PMID: 21900087.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCTClinical Trials
    65. Blood pressure targets in subjects with type 2 diabetes mellitus/impaired fasting glucose: observations from traditional and bayesian random-effects meta-analyses of randomized trials. Circulation. 2011 Jun 21; 123(24):2799-810, 9 p following 810. Bangalore S, Kumar S, Lobach I, Messerli FH. PMID: 21632497.
      View in: PubMed   Mentions: 80     Fields:    Translation:Humans
    66. Mexican urban occupational health in the US: a population at risk. J Community Health. 2011 Apr; 36(2):175-9. Gany F, Dobslaw R, Ramirez J, Tonda J, Lobach I, Leng J. PMID: 20614170.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    67. Factors associated with frequent utilization of crisis substance use detoxification services. J Addict Dis. 2011 Apr; 30(2):116-22. Carrier E, McNeely J, Lobach I, Tay S, Gourevitch MN, Raven MC. PMID: 21491293.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    68. Cancer portal project: a multidisciplinary approach to cancer care among Hispanic patients. J Oncol Pract. 2011 Jan; 7(1):31-8. Gany F, Ramirez J, Nierodzick ML, McNish T, Lobach I, Leng J. PMID: 21532808.
      View in: PubMed   Mentions: 11     Fields:    
    69. Semiparametric Bayesian analysis of gene-environment interactions with error in measurement of environmental covariates and missing genetic data. Stat Interface. 2011; 4(3):305-316. Lobach I, Mallick B, Carroll RJ. PMID: 21949562.
      View in: PubMed   Mentions:
    70. Genotype-based association mapping of complex diseases: gene-environment interactions with multiple genetic markers and measurement error in environmental exposures. Genet Epidemiol. 2010 Dec; 34(8):792-802. Lobach I, Fan R, Carroll RJ. PMID: 21031455.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansPHPublic Health
    71. Normal intima-media thickness on carotid ultrasound reliably excludes an ischemic cause of cardiomyopathy. Am Heart J. 2010 Jun; 159(6):1059-66. Reynolds HR, Steckman DA, Tunick PA, Kronzon I, Lobach I, Rosenzweig BP. PMID: 20569720.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    72. Haplotype-based regression analysis and inference of case-control studies with unphased genotypes and measurement errors in environmental exposures. Biometrics. 2008 Sep; 64(3):673-84. Lobach I, Carroll RJ, Spinka C, Gail MH, Chatterjee N. PMID: 18047538.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansPHPublic Health
    73. Genotype-based Bayesian Analysis of Gene-Environment Interactions with Multiple Genetic Markers and Misclassification in Environmental Factors. Journal of Probability and Statistics. 2012. View Publication.
    Iryna's Networks
    Concepts (371)
    Derived automatically from this person's publications.
    _
    Co-Authors (94)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _