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Ishan Deshpande, PhD

Title(s)Postdoctoral Scholar, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
ORCID ORCID Icon0000-0002-8276-9635 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Pune, IndiaM.Sc.05/2012Biotechnology
    University of Basel, SwitzerlandPh.D.09/2017Structural biology

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Hedgehog signaling by the Smoothened receptor
    Swiss National Science Foundation (SNSF) P400PB-180798Aug 1, 2018 - Jul 31, 2020
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Deshpande I, Keusch JJ, Challa K, Iesmantavicius V, Gasser SM, Gut H. The Sir4 H-BRCT domain interacts with phospho-proteins to sequester and repress yeast heterochromatin. EMBO J. 2020 Jan 02; 39(1):e103976. PMID: 31894584.
      View in: PubMed
    2. Deshpande I, Keusch JJ, Challa K, Iesmantavicius V, Gasser SM, Gut H. The Sir4 H-BRCT domain interacts with phospho-proteins to sequester and repress yeast heterochromatin. EMBO J. 2019 10 15; 38(20):e101744. PMID: 31515872.
      View in: PubMed
    3. Deshpande I, Liang J, Hedeen D, Roberts KJ, Zhang Y, Ha B, Latorraca NR, Faust B, Dror RO, Beachy PA, Myers BR, Manglik A. Smoothened stimulation by membrane sterols drives Hedgehog pathway activity. Nature. 2019 07; 571(7764):284-288. PMID: 31263273.
      View in: PubMed
    4. Deshpande I, Seeber A, Shimada K, Keusch JJ, Gut H, Gasser SM. Structural Basis of Mec1-Ddc2-RPA Assembly and Activation on Single-Stranded DNA at Sites of Damage. Mol Cell. 2017 Oct 19; 68(2):431-445.e5. PMID: 29033322.
      View in: PubMed
    5. Seeber A, Hegnauer AM, Hustedt N, Deshpande I, Poli J, Eglinger J, Pasero P, Gut H, Shinohara M, Hopfner KP, Shimada K, Gasser SM. RPA Mediates Recruitment of MRX to Forks and Double-Strand Breaks to Hold Sister Chromatids Together. Mol Cell. 2016 12 01; 64(5):951-966. PMID: 27889450.
      View in: PubMed