Itzik Norman, PhD

Title(s)Postdoctoral Scholar, Neurological Surgery
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB
San Francisco CA 94117
Phone415-502-7346
ORCID ORCID Icon0000-0002-7401-5411 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Weizmann Institute of Science, IsraelPh.D.03/2021Neuroscience
    Weizmann Institute of Science, IsraelMs.c.02/2016Neurobiology
    The Hebrew University of Jerusalem, IsraelB.A.09/2013Cognitive Science and Philosophy
    Collapse Awards and Honors
    Weizmann Institute of Science2016  - 2020John F. Kennedy doctoral award
    The Hebrew University of Jerusalem2009  - 2011Dean's Honor list
    Tel-Aviv University2020  - 2020FMEM 2020 outstanding student award in tribute to Dr. Fani Andelman

    Collapse Overview 
    Collapse Overview
    Our ability to recall previous personal experiences – things that we have seen, heard, done, etc. – requires coordinated interactions among distributed brain networks that collectively encode, store, retrieve and reenact the content of our memories. Memory of this type, also known as episodic memory, enables us to transcend the 'here and now' and move mentally in time: a few seconds backwards, e.g., when we try to follow a lecture or a conversation, or a few years backwards, when we recall our last trip to Paris. Similar neurocognitive processes also enable us to envision and plan the future by intrinsic simulation of various scenarios.

    In his doctoral studies at the Weizmann Institute of Science, Dr. Yitzhak (Itzik) Norman investigated the neuronal mechanisms underlying memory retrieval in the human brain. His results uncovered a bidirectional hippocampal-cortical interaction that arises 1-2 seconds prior to the onset of a conscious, reportable recollection. In this interaction, the hippocampus elicits massive neuronal activity bursts known as Sharp Wave Ripples (SWRs). Such activation events have been extensively studied in animal models (mostly rodents) in recent years and were shown to involve a synchronous discharge of millions of pyramidal neurons located on the hippocampus output pathway. By measuring local neuronal activity from both the hippocampus and the cortex of awake individuals, Dr. Norman was able to demonstrate for the first time that SWRs play a major role in recollection, coordinating re-activation of content-selective cortical representations during retrieval. Furthermore, his work characterized the potent and widespread impact of SWRs on the rest of the brain – demonstrating robust SWR-related activations in various association cortices, as well as in prefrontal regions and the default mode network, which are linked to memory functions.

    Currently in the Department of Neurological Surgery at the University of California, San Francisco, Dr. Norman examines how we encode and retrieve a specific conversation in our memory. Through a combination of non-invasive brain imaging techniques (high-field fMRI) and intracranial recordings in patients (ECoG), Dr. Norman seeks to deepen our mechanistic understanding of human declarative memory and shed new light on language and memory impairments that accompany neurodegenerative diseases such as Alzheimer’s and dementia, as well as speech problems caused by epilepsy and stroke.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hippocampal ripples and their coordinated dialogue with the default mode network during recent and remote recollection. Neuron. 2021 09 01; 109(17):2767-2780.e5. Norman Y, Raccah O, Liu S, Parvizi J, Malach R. PMID: 34297916.
      View in: PubMed   Mentions: 1     Fields:    
    2. Face-Selective Units in Human Ventral Temporal Cortex Reactivate during Free Recall. J Neurosci. 2021 04 14; 41(15):3386-3399. Khuvis S, Yeagle EM, Norman Y, Grossman S, Malach R, Mehta AD. PMID: 33431634.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. Hippocampal sharp-wave ripples linked to visual episodic recollection in humans. Science. 2019 08 16; 365(6454). Norman Y, Yeagle EM, Khuvis S, Harel M, Mehta AD, Malach R. PMID: 31416934.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    4. Neuronal baseline shifts underlying boundary setting during free recall. Nat Commun. 2017 11 03; 8(1):1301. Norman Y, Yeagle EM, Harel M, Mehta AD, Malach R. PMID: 29101322.
      View in: PubMed   Mentions: 5     Fields:    
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