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J. Michael Bishop, MD

Title(s)Professor Emeritus, Microbiology and Immunology
SchoolSchool of Medicine
Phone415-476-5158
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    Other Positions
    Title(s)Director, GW Hooper Foundation, Microbiology and Immunology


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    Dr. J. Michael Bishop, Chancellor Emeritus of UCSF, serves as a Professor in the Department of Microbiology and Immunology and Director of the GW Hooper Foundation. Bishop joined the UCSF faculty in 1968 and in 1981 assumed the post of Hooper director. He was named UCSF chancellor in February 1998. Since 2004, he also has held the Arthur and Toni Rembe Rock Distinguished Professorship. While serving as chancellor, Bishop continued to teach medical students and run his distinguished research lab.

    Bishop and his colleague Harold Varmus, MD, shared the Nobel Prize in Physiology or Medicine in 1989 for cancer research. Bishop and Glenn Seaborg, who served as chancellor at UC Berkeley from 1958-61, are the only two Nobel laureates to have served as chancellors in the 10-campus UC system.

    Dr. Bishop and his team research the genetic underpinnings of cancer, in particular the large group of cellular genes known as proto-oncogenes (see link to the Bishop Lab below).

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    RETROVIRUSES AND CANCER GENES
    NIH R35CA044338Jul 1, 1987 - Apr 30, 2002
    Role: Principal Investigator
    ROUS SARCOMA VIRUS: REPLICATION AND CELL TRANSFORMATION
    NIH R01CA012705Jun 30, 1976 - Feb 28, 1990
    Role: Principal Investigator
    The Molecular Analysis of Tumor Viruses
    NIH T32CA009043Jun 30, 1975 - Jun 30, 2011
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chow EK, Fan LL, Chen X, Bishop JM. Oncogene-specific formation of chemoresistant murine hepatic cancer stem cells. Hepatology. 2012 Oct; 56(4):1331-41. PMID: 22505225; PMCID: PMC3418440.
      View in: PubMed, PubMed Central
    2. Yuneva MO, Fan TW, Allen TD, Higashi RM, Ferraris DV, Tsukamoto T, Matés JM, Alonso FJ, Wang C, Seo Y, Chen X, Bishop JM. The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metab. 2012 Feb 08; 15(2):157-70. PMID: 22326218; PMCID: PMC3282107.
      View in: PubMed, PubMed Central
    3. Allen TD, Rodriguez EM, Jones KD, Bishop JM. Activated Notch1 induces lung adenomas in mice and cooperates with Myc in the generation of lung adenocarcinoma. Cancer Res. 2011 Sep 15; 71(18):6010-8. PMID: 21803744; PMCID: PMC3174331.
      View in: PubMed, PubMed Central
    4. Allen TD, Zhu CQ, Jones KD, Yanagawa N, Tsao MS, Bishop JM. Interaction between MYC and MCL1 in the genesis and outcome of non-small-cell lung cancer. Cancer Res. 2011 Mar 15; 71(6):2212-21. PMID: 21406400; PMCID: PMC3076947.
      View in: PubMed, PubMed Central
    5. Goga A, Yang D, Tward AD, Morgan DO, Bishop JM. Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nat Med. 2007 Jul; 13(7):820-7. PMID: 17589519.
      View in: PubMed
    6. Bishop JM. Mary Lasker and her prizes: an appreciation. JAMA. 2005 Sep 21; 294(11):1418-9. PMID: 16174706.
      View in: PubMed
    7. Welm AL, Kim S, Welm BE, Bishop JM. MET and MYC cooperate in mammary tumorigenesis. Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12):4324-9. PMID: 15738393; PMCID: PMC552784.
      View in: PubMed, PubMed Central
    8. Kim S, Chin K, Gray JW, Bishop JM. A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer. Proc Natl Acad Sci U S A. 2004 Nov 16; 101(46):16251-6. PMID: 15528276; PMCID: PMC528940.
      View in: PubMed, PubMed Central
    9. Yang D, Welm A, Bishop JM. Cell division and cell survival in the absence of survivin. Proc Natl Acad Sci U S A. 2004 Oct 19; 101(42):15100-5. PMID: 15477601; PMCID: PMC524069.
      View in: PubMed, PubMed Central
    10. Huang Z, Traugh JA, Bishop JM. Negative control of the Myc protein by the stress-responsive kinase Pak2. Mol Cell Biol. 2004 Feb; 24(4):1582-94. PMID: 14749374; PMCID: PMC344192.
      View in: PubMed, PubMed Central
    11. Yang D, Buchholz F, Huang Z, Goga A, Chen CY, Brodsky FM, Bishop JM. Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9942-7. PMID: 12096193; PMCID: PMC126604.
      View in: PubMed, PubMed Central
    12. Wang R, Ferrell LD, Faouzi S, Maher JJ, Bishop JM. Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice. J Cell Biol. 2001 May 28; 153(5):1023-34. PMID: 11381087; PMCID: PMC2174327.
      View in: PubMed, PubMed Central
    13. Kogan SC, Brown DE, Shultz DB, Truong BT, Lallemand-Breitenbach V, Guillemin MC, Lagasse E, Weissman IL, Bishop JM. BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia. J Exp Med. 2001 Feb 19; 193(4):531-43. PMID: 11181704; PMCID: PMC2195904.
      View in: PubMed, PubMed Central
    14. Buchholz F, Refaeli Y, Trumpp A, Bishop JM. Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse. EMBO Rep. 2000 Aug; 1(2):133-9. PMID: 11265752; PMCID: PMC1084259.
      View in: PubMed, PubMed Central
    15. Weiss WA, Godfrey T, Francisco C, Bishop JM. Genome-wide screen for allelic imbalance in a mouse model for neuroblastoma. Cancer Res. 2000 May 01; 60(9):2483-7. PMID: 10811128.
      View in: PubMed
    16. Trumpp A, Depew MJ, Rubenstein JL, Bishop JM, Martin GR. Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev. 1999 Dec 01; 13(23):3136-48. PMID: 10601039; PMCID: PMC317178.
      View in: PubMed, PubMed Central
    17. Felsher DW, Bishop JM. Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell. 1999 Aug; 4(2):199-207. PMID: 10488335.
      View in: PubMed
    18. Smith-McCune K, Kalman D, Robbins C, Shivakumar S, Yuschenkoff L, Bishop JM. Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130. Proc Natl Acad Sci U S A. 1999 Jun 08; 96(12):6999-7004. PMID: 10359828; PMCID: PMC22035.
      View in: PubMed, PubMed Central
    19. Kalman D, Gomperts SN, Hardy S, Kitamura M, Bishop JM. Ras family GTPases control growth of astrocyte processes. Mol Biol Cell. 1999 May; 10(5):1665-83. PMID: 10233170.
      View in: PubMed
    20. Felsher DW, Bishop JM. Transient excess of MYC activity can elicit genomic instability and tumorigenesis. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3940-4. PMID: 10097142; PMCID: PMC22399.
      View in: PubMed, PubMed Central
    21. Zhu J, Woods D, McMahon M, Bishop JM. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev. 1998 Oct 01; 12(19):2997-3007. PMID: 9765202; PMCID: PMC317194.
      View in: PubMed, PubMed Central
    22. Capobianco AJ, Zagouras P, Blaumueller CM, Artavanis-Tsakonas S, Bishop JM. Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2. Mol Cell Biol. 1997 Nov; 17(11):6265-73. PMID: 9343387; PMCID: PMC232477.
      View in: PubMed, PubMed Central
    23. Bishop JM. Ethic of science. New Sci. 1981 Nov 12; 92(1279):457. PMID: 11664183.
      View in: PubMed
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