J. Michael Bishop, MD

Title(s)Professor Emeritus, Microbiology and Immunology
SchoolSchool of Medicine
Address35 Medical Center Way, #900F
San Francisco CA 94143
Phone415-476-5158
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    Other Positions
    Title(s)Director, GW Hooper Foundation


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    Dr. J. Michael Bishop, Chancellor Emeritus of UCSF, serves as a Professor in the Department of Microbiology and Immunology and Director of the GW Hooper Foundation. Bishop joined the UCSF faculty in 1968 and in 1981 assumed the post of Hooper director. He was named UCSF chancellor in February 1998. Since 2004, he also has held the Arthur and Toni Rembe Rock Distinguished Professorship. While serving as chancellor, Bishop continued to teach medical students and run his distinguished research lab.

    Bishop and his colleague Harold Varmus, MD, shared the Nobel Prize in Physiology or Medicine in 1989 for cancer research. Bishop and Glenn Seaborg, who served as chancellor at UC Berkeley from 1958-61, are the only two Nobel laureates to have served as chancellors in the 10-campus UC system.

    Dr. Bishop and his team research the genetic underpinnings of cancer, in particular the large group of cellular genes known as proto-oncogenes (see link to the Bishop Lab below).
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    RETROVIRUSES AND CANCER GENES
    NIH R35CA044338Jul 1, 1987 - Apr 30, 2002
    Role: Principal Investigator
    ROUS SARCOMA VIRUS: REPLICATION AND CELL TRANSFORMATION
    NIH R01CA012705Jun 30, 1976 - Feb 28, 1990
    Role: Principal Investigator
    The Molecular Analysis of Tumor Viruses
    NIH T32CA009043Jun 30, 1975 - Jun 30, 2011
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Microscopy with ultraviolet surface excitation for rapid slide-free histology. Nat Biomed Eng. 2017 12; 1(12):957-966. Fereidouni F, Harmany ZT, Tian M, Todd A, Kintner JA, McPherson JD, Borowsky AD, Bishop J, Bishop J, Lechpammer M, Demos SG, Levenson R. PMID: 31015706; PMCID: PMC6223324.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimals
    2. Oncogene-specific formation of chemoresistant murine hepatic cancer stem cells. Hepatology. 2012 Oct; 56(4):1331-41. Chow EK, Fan LL, Chen X, Bishop JM. PMID: 22505225; PMCID: PMC3418440.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    3. The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metab. 2012 Feb 08; 15(2):157-70. Yuneva MO, Fan TW, Allen TD, Higashi RM, Ferraris DV, Tsukamoto T, Matés JM, Alonso FJ, Wang C, Seo Y, Chen X, Bishop JM. PMID: 22326218; PMCID: PMC3282107.
      View in: PubMed   Mentions: 358     Fields:    Translation:HumansAnimalsCells
    4. Activated Notch1 induces lung adenomas in mice and cooperates with Myc in the generation of lung adenocarcinoma. Cancer Res. 2011 Sep 15; 71(18):6010-8. Allen TD, Rodriguez EM, Jones KD, Bishop JM. PMID: 21803744; PMCID: PMC3174331.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimals
    5. Interaction between MYC and MCL1 in the genesis and outcome of non-small-cell lung cancer. Cancer Res. 2011 Mar 15; 71(6):2212-21. Allen TD, Zhu CQ, Jones KD, Yanagawa N, Tsao MS, Bishop JM. PMID: 21406400; PMCID: PMC3076947.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    6. Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nat Med. 2007 Jul; 13(7):820-7. Goga A, Yang D, Tward AD, Morgan DO, Bishop JM. PMID: 17589519.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansAnimalsCells
    7. beta-Catenin/Wnt signaling regulates expression of the membrane type 3 matrix metalloproteinase in gastric cancer. Cancer Res. 2006 May 01; 66(9):4734-41. Lowy AM, Clements WM, Bishop J, Bishop J, Kong L, Bonney T, Sisco K, Aronow B, Fenoglio-Preiser C, Groden J. PMID: 16651426.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    8. Mary Lasker and her prizes: an appreciation. JAMA. 2005 Sep 21; 294(11):1418-9. Bishop JM. PMID: 16174706.
      View in: PubMed   Mentions:    Fields:    
    9. MET and MYC cooperate in mammary tumorigenesis. Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12):4324-9. Welm AL, Kim S, Welm BE, Bishop JM. PMID: 15738393; PMCID: PMC552784.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    10. A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer. Proc Natl Acad Sci U S A. 2004 Nov 16; 101(46):16251-6. Kim S, Chin K, Gray JW, Bishop JM. PMID: 15528276; PMCID: PMC528940.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    11. Cell division and cell survival in the absence of survivin. Proc Natl Acad Sci U S A. 2004 Oct 19; 101(42):15100-5. Yang D, Welm A, Bishop JM. PMID: 15477601; PMCID: PMC524069.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    12. Negative control of the Myc protein by the stress-responsive kinase Pak2. Mol Cell Biol. 2004 Feb; 24(4):1582-94. Huang Z, Traugh JA, Bishop JM. PMID: 14749374; PMCID: PMC344192.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    13. Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9942-7. Yang D, Buchholz F, Huang Z, Goga A, Chen CY, Brodsky FM, Bishop JM. PMID: 12096193; PMCID: PMC126604.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    14. Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice. J Cell Biol. 2001 May 28; 153(5):1023-34. Wang R, Ferrell LD, Faouzi S, Maher JJ, Bishop JM. PMID: 11381087; PMCID: PMC2174327.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimalsCells
    15. BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia. J Exp Med. 2001 Feb 19; 193(4):531-43. Kogan SC, Brown DE, Shultz DB, Truong BT, Lallemand-Breitenbach V, Guillemin MC, Lagasse E, Weissman IL, Bishop JM. PMID: 11181704; PMCID: PMC2195904.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    16. Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse. EMBO Rep. 2000 Aug; 1(2):133-9. Buchholz F, Refaeli Y, Trumpp A, Bishop JM. PMID: 11265752; PMCID: PMC1084259.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    17. Genome-wide screen for allelic imbalance in a mouse model for neuroblastoma. Cancer Res. 2000 May 01; 60(9):2483-7. Weiss WA, Godfrey T, Francisco C, Bishop JM. PMID: 10811128.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    18. Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev. 1999 Dec 01; 13(23):3136-48. Trumpp A, Depew MJ, Rubenstein JL, Bishop JM, Martin GR. PMID: 10601039; PMCID: PMC317178.
      View in: PubMed   Mentions: 159     Fields:    Translation:AnimalsCells
    19. Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell. 1999 Aug; 4(2):199-207. Felsher DW, Bishop JM. PMID: 10488335.
      View in: PubMed   Mentions: 382     Fields:    Translation:HumansAnimalsCells
    20. Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130. Proc Natl Acad Sci U S A. 1999 Jun 08; 96(12):6999-7004. Smith-McCune K, Kalman D, Robbins C, Shivakumar S, Yuschenkoff L, Bishop JM. PMID: 10359828; PMCID: PMC22035.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    21. Ras family GTPases control growth of astrocyte processes. Mol Biol Cell. 1999 May; 10(5):1665-83. Kalman D, Gomperts SN, Hardy S, Kitamura M, Bishop JM. PMID: 10233170; PMCID: PMC30489.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    22. Transient excess of MYC activity can elicit genomic instability and tumorigenesis. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3940-4. Felsher DW, Bishop JM. PMID: 10097142; PMCID: PMC22399.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansAnimalsCells
    23. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev. 1998 Oct 01; 12(19):2997-3007. Zhu J, Woods D, McMahon M, Bishop JM. PMID: 9765202; PMCID: PMC317194.
      View in: PubMed   Mentions: 262     Fields:    Translation:HumansAnimalsCells
    24. Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2. Mol Cell Biol. 1997 Nov; 17(11):6265-73. Capobianco AJ, Zagouras P, Blaumueller CM, Artavanis-Tsakonas S, Bishop JM. PMID: 9343387; PMCID: PMC232477.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    25. Ethic of science. New Sci. 1981 Nov 12; 92(1279):457. Bishop JM. PMID: 11664183.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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