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Jack Youngren, PhD

TitleAssociate Adjunct Professor
SchoolUCSF School of Medicine
DepartmentMedicine
Address2340 Sutter Street
San Francisco CA 94115
Phone415-476-9443
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division

    Collapse Research 
    Collapse Research Activities and Funding
    DAUs as IGF-1 Receptor Inhibitors in Breast Cancer
    NIH/NCI R01CA112042May 1, 2007 - Mar 31, 2012
    Role: Principal Investigator
    Carbonic Anhydrases in Obesity and Insulin Resistance
    NIH/NIDDK R21DK060140May 2, 2002 - Apr 30, 2005
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Aggarwal R, Behr S, Paris PL, Truillet C, Parker MFL, Huynh LT, Wei J, Hann B, Youngren J, Premasekharan G, Huang J, Ranatunga N, Chang E, Gao KT, Ryan CJ, Small EJ, Evans MJ. Real-Time Transferrin-Based PET Detects MYC-Positive Prostate Cancer. Mol Cancer Res. 2017 Sep; 15(9):1221-1229. PMID: 28592703.
      View in: PubMed
    2. Quigley D, Alumkal JJ, Wyatt AW, Kothari V, Foye A, Lloyd P, Aggarwal R, Kim W, Lu E, Schwartzman J, Beja K, Annala M, Das R, Diolaiti M, Pritchard CC, Thomas GV, Tomlins SA, Knudsen KE, Lord CJ, Ryan CJ, Youngren J, Beer TM, Ashworth A, Small EJ, Feng FY. Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors. Cancer Discov. 2017 Sep; 7(9):999-1005. PMID: 28450426.
      View in: PubMed
    3. Azad AA, Volik SV, Wyatt AW, Haegert A, Le Bihan S, Bell RH, Anderson SA, McConeghy B, Shukin R, Bazov J, Youngren J, Paris P, Thomas G, Small EJ, Wang Y, Gleave ME, Collins CC, Chi KN. Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer. Clin Cancer Res. 2015 May 15; 21(10):2315-24. PMID: 25712683.
      View in: PubMed
    4. Catalano KJ, Maddux BA, Szary J, Youngren J, Goldfine ID, Schaufele F. Insulin resistance induced by hyperinsulinemia coincides with a persistent alteration at the insulin receptor tyrosine kinase domain. PLoS One. 2014; 9(9):e108693. PMID: 25259572; PMCID: PMC4178179.
    5. Masharani U, Gjerde C, McCoy S, Maddux BA, Hessler D, Goldfine ID, Youngren J. Chromium supplementation in non-obese non-diabetic subjects is associated with a decline in insulin sensitivity. BMC Endocr Disord. 2012 Nov 30; 12:31. PMID: 23194380; PMCID: PMC3537689.
    6. Troib A, Landau D, Youngren J, Kachko L, Rabkin R, Segev Y. The effects of type 1 IGF receptor inhibition in a mouse model of diabetic kidney disease. Growth Horm IGF Res. 2011 Oct; 21(5):285-91. PMID: 21865067; PMCID: PMC4238882.
    7. Masharani UB, Maddux BA, Li X, Sakkas GK, Mulligan K, Schambelan M, Goldfine ID, Youngren J. Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle. PLoS One. 2011 May 11; 6(5):e19878. PMID: 21589939; PMCID: PMC3092773.
    8. Engen W, O'Brien TE, Kelly B, Do J, Rillera L, Stapleton LK, Youngren J, Anderson MO. Synthesis of aryl-heteroaryl ureas (AHUs) based on 4-aminoquinoline and their evaluation against the insulin-like growth factor receptor (IGF-1R). Bioorg Med Chem. 2010 Aug 15; 18(16):5995-6005. PMID: 20643554; PMCID: PMC2918655.
    9. Masharani U, Gjerde C, Evans JL, Youngren J, Goldfine ID. Effects of controlled-release alpha lipoic acid in lean, nondiabetic patients with polycystic ovary syndrome. J Diabetes Sci Technol. 2010 Mar 01; 4(2):359-64. PMID: 20307398; PMCID: PMC2864173.
    10. Masharani U, Goldfine ID, Youngren J. Influence of gender on the relationship between insulin sensitivity, adiposity, and plasma lipids in lean nondiabetic subjects. Metabolism. 2009 Nov; 58(11):1602-8. PMID: 19604524; PMCID: PMC2763945.
    11. Li F, Pham JD, Anderson MO, Youngren J. Nordihydroguaiaretic acid inhibits transforming growth factor beta type 1 receptor activity and downstream signaling. Eur J Pharmacol. 2009 Aug 15; 616(1-3):31-7. PMID: 19540220; PMCID: PMC2742219.
    12. Ryan CJ, Zavodovskaya M, Youngren J, Campbell M, Diamond M, Jones J, Shiry L, Allan G, Maddux BA, Goldfine ID. Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells. Prostate. 2008 Aug 01; 68(11):1232-40. PMID: 18491370.
      View in: PubMed
    13. Ryan CJ, Harzstark AH, Rosenberg J, Lin A, Claros C, Goldfine ID, Kerner JF, Small EJ, Youngren J. A pilot dose-escalation study of the effects of nordihydroguareacetic acid on hormone and prostate specific antigen levels in patients with relapsed prostate cancer. BJU Int. 2008 Feb; 101(4):436-9. PMID: 18234062.
      View in: PubMed
    14. Zavodovskaya M, Campbell MJ, Maddux BA, Shiry L, Allan G, Hodges L, Kushner P, Kerner JA, Youngren J, Goldfine ID. Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells. J Cell Biochem. 2008 Feb 01; 103(2):624-35. PMID: 17562544.
      View in: PubMed
    15. Goldfine ID, Maddux BA, Youngren J, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L. The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities. Endocr Rev. 2008 Feb; 29(1):62-75. PMID: 18199690; PMCID: PMC2244935.
    16. Meyer GE, Chesler L, Liu D, Gable K, Maddux BA, Goldenberg DD, Youngren J, Goldfine ID, Weiss WA, Matthay KK, Rosenthal SM. Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells. J Cell Biochem. 2007 Dec 15; 102(6):1529-41. PMID: 17486636; PMCID: PMC3001106.
    17. Li X, Youngren J, Hyun B, Sakkas GK, Mulligan K, Majumdar S, Masharani UB, Schambelan M, Goldfine ID. Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T. Magn Reson Imaging. 2008 Feb; 26(2):188-97. PMID: 17683890; PMCID: PMC2713003.
    18. Blecha JE, Anderson MO, Chow JM, Guevarra CC, Pender C, Penaranda C, Zavodovskaya M, Youngren J, Berkman CE. Inhibition of IGF-1R and lipoxygenase by nordihydroguaiaretic acid (NDGA) analogs. Bioorg Med Chem Lett. 2007 Jul 15; 17(14):4026-9. PMID: 17502145; PMCID: PMC2253493.
    19. Youngren J. Regulation of insulin receptor function. Cell Mol Life Sci. 2007 Apr; 64(7-8):873-91. PMID: 17347799.
      View in: PubMed
    20. Pender C, Trentadue AR, Pories WJ, Dohm GL, Houmard JA, Youngren J. Expression of genes regulating malonyl-CoA in human skeletal muscle. J Cell Biochem. 2006 Oct 15; 99(3):860-7. PMID: 16721829.
      View in: PubMed
    21. Anderson MO, Yu H, Penaranda C, Maddux BA, Goldfine ID, Youngren J, Guy RK. Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor. J Comb Chem. 2006 Sep-Oct; 8(5):784-90. PMID: 16961415.
      View in: PubMed
    22. Gable KL, Maddux BA, Penaranda C, Zavodovskaya M, Campbell MJ, Lobo M, Robinson L, Schow S, Kerner JA, Goldfine ID, Youngren J. Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. Mol Cancer Ther. 2006 Apr; 5(4):1079-86. PMID: 16648580.
      View in: PubMed
    23. Maddux BA, Chang YN, Accili D, McGuinness OP, Youngren J, Goldfine ID. Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia. Am J Physiol Endocrinol Metab. 2006 Apr; 290(4):E746-9. PMID: 16278247.
      View in: PubMed
    24. Youngren J, Gable K, Penaranda C, Maddux BA, Zavodovskaya M, Lobo M, Campbell M, Kerner J, Goldfine ID. Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells. Breast Cancer Res Treat. 2005 Nov; 94(1):37-46. PMID: 16142439.
      View in: PubMed
    25. Pender C, Goldfine ID, Kulp JL, Tanner CJ, Maddux BA, MacDonald KG, Houmard JA, Youngren J. Analysis of insulin-stimulated insulin receptor activation and glucose transport in cultured skeletal muscle cells from obese subjects. Metabolism. 2005 May; 54(5):598-603. PMID: 15877289.
      View in: PubMed
    26. Dong H, Maddux BA, Altomonte J, Meseck M, Accili D, Terkeltaub R, Johnson K, Youngren J, Goldfine ID. Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance. Diabetes. 2005 Feb; 54(2):367-72. PMID: 15677494.
      View in: PubMed
    27. Corbould A, Kim YB, Youngren J, Pender C, Kahn BB, Lee A, Dunaif A. Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling. Am J Physiol Endocrinol Metab. 2005 May; 288(5):E1047-54. PMID: 15613682.
      View in: PubMed
    28. Evans JL, Youngren J, Goldfine ID. Effective treatments for insulin resistance: trim the fat and douse the fire. Trends Endocrinol Metab. 2004 Nov; 15(9):425-31. PMID: 15519889.
      View in: PubMed
    29. Pender C, Goldfine ID, Tanner CJ, Pories WJ, MacDonald KG, Havel PJ, Houmard JA, Youngren J. Muscle insulin receptor concentrations in obese patients post bariatric surgery: relationship to hyperinsulinemia. Int J Obes Relat Metab Disord. 2004 Mar; 28(3):363-9. PMID: 14724657.
      View in: PubMed
    30. Pender C, Goldfine ID, Manchem VP, Evans JL, Spevak WR, Shi S, Rao S, Bajjalieh S, Maddux BA, Youngren J. Regulation of insulin receptor function by a small molecule insulin receptor activator. J Biol Chem. 2002 Nov 15; 277(46):43565-71. PMID: 12213804.
      View in: PubMed
    31. Li M, Youngren J, Dunaif A, Goldfine ID, Maddux BA, Zhang BB, Evans JL. Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators. J Clin Endocrinol Metab. 2002 Sep; 87(9):4088-93. PMID: 12213853.
      View in: PubMed
    32. Stefan N, Vozarova B, Funahashi T, Matsuzawa Y, Weyer C, Lindsay RS, Youngren J, Havel PJ, Pratley RE, Bogardus C, Tataranni PA. Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans. Diabetes. 2002 Jun; 51(6):1884-8. PMID: 12031977.
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    33. Pender C, Ortmeyer HK, Hansen BC, Goldfine ID, Youngren J. Elevated plasma cell membrane glycoprotein levels and diminished insulin receptor autophosphorylation in obese, insulin-resistant rhesus monkeys. Metabolism. 2002 Apr; 51(4):465-70. PMID: 11912555.
      View in: PubMed
    34. Youngren J, Paik J, Barnard RJ. Impaired insulin-receptor autophosphorylation is an early defect in fat-fed, insulin-resistant rats. J Appl Physiol (1985). 2001 Nov; 91(5):2240-7. PMID: 11641367.
      View in: PubMed
    35. Li M, Youngren J, Manchem VP, Kozlowski M, Zhang BB, Maddux BA, Goldfine ID. Small molecule insulin receptor activators potentiate insulin action in insulin-resistant cells. Diabetes. 2001 Oct; 50(10):2323-8. PMID: 11574415.
      View in: PubMed
    36. Youngren J, Keen S, Kulp JL, Tanner CJ, Houmard JA, Goldfine ID. Enhanced muscle insulin receptor autophosphorylation with short-term aerobic exercise training. Am J Physiol Endocrinol Metab. 2001 Mar; 280(3):E528-33. PMID: 11171609.
      View in: PubMed
    37. Shao J, Catalano PM, Yamashita H, Ruyter I, Smith S, Youngren J, Friedman JE. Decreased insulin receptor tyrosine kinase activity and plasma cell membrane glycoprotein-1 overexpression in skeletal muscle from obese women with gestational diabetes mellitus (GDM): evidence for increased serine/threonine phosphorylation in pregnancy and GDM. Diabetes. 2000 Apr; 49(4):603-10. PMID: 10871198.
      View in: PubMed
    38. Goldfine ID, Maddux BA, Youngren J, Trischitta V, Frittitta L. Role of PC-1 in the etiology of insulin resistance. Ann N Y Acad Sci. 1999 Nov 18; 892:204-22. PMID: 10842664.
      View in: PubMed
    39. Youngren J, Goldfine ID, Pratley RE. Insulin receptor autophosphorylation in cultured myoblasts correlates to glucose disposal in Pima Indians. Am J Physiol. 1999 May; 276(5 Pt 1):E990-4. PMID: 10329994.
      View in: PubMed
    40. Goldfine ID, Maddux BA, Youngren J, Frittitta L, Trischitta V, Dohm GL. Membrane glycoprotein PC-1 and insulin resistance. Mol Cell Biochem. 1998 May; 182(1-2):177-84. PMID: 9609127.
      View in: PubMed
    41. Goldfine ID, Youngren J. Contributions of the American Journal of Physiology to the discovery of insulin. Am J Physiol. 1998 Feb; 274(2 Pt 1):E207-9. PMID: 9486148.
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    42. Youngren J, Goldfine ID, Pratley RE. Decreased muscle insulin receptor kinase correlates with insulin resistance in normoglycemic Pima Indians. Am J Physiol. 1997 Aug; 273(2 Pt 1):E276-83. PMID: 9277380.
      View in: PubMed
    43. Frittitta L, Youngren J, Sbraccia P, D'Adamo M, Buongiorno A, Vigneri R, Goldfine ID, Trischitta V. Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-alpha gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity. Diabetologia. 1997 Mar; 40(3):282-9. PMID: 9084965.
      View in: PubMed
    44. Ozel B, Youngren J, Kim JK, Goldfine ID, Sung CK, Youn JH. The development of insulin resistance with high fat feeding in rats does not involve either decreased insulin receptor tyrosine kinase activity or membrane glycoprotein PC-1. Biochem Mol Med. 1996 Dec; 59(2):174-81. PMID: 8986641.
      View in: PubMed
    45. Frittitta L, Youngren J, Vigneri R, Maddux BA, Trischitta V, Goldfine ID. PC-1 content in skeletal muscle of non-obese, non-diabetic subjects: relationship to insulin receptor tyrosine kinase and whole body insulin sensitivity. Diabetologia. 1996 Oct; 39(10):1190-5. PMID: 8897006.
      View in: PubMed
    46. Youngren J, Maddux BA, Sasson S, Sbraccia P, Tapscott EB, Swanson MS, Dohm GL, Goldfine ID. Skeletal muscle content of membrane glycoprotein PC-1 in obesity. Relationship to muscle glucose transport. Diabetes. 1996 Oct; 45(10):1324-8. PMID: 8826966.
      View in: PubMed
    47. Youngren J, Barnard RJ. Effects of acute and chronic exercise on skeletal muscle glucose transport in aged rats. J Appl Physiol (1985). 1995 May; 78(5):1750-6. PMID: 7649909.
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    48. Maddux BA, Sbraccia P, Kumakura S, Sasson S, Youngren J, Fisher A, Spencer S, Grupe A, Henzel W, Stewart TA. Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus. Nature. 1995 Feb 02; 373(6513):448-51. PMID: 7830796.
      View in: PubMed
    49. Barnard RJ, Youngren J, Martin DA. Diet, not aging, causes skeletal muscle insulin resistance. Gerontology. 1995; 41(4):205-11. PMID: 7557497.
      View in: PubMed
    50. Barnard RJ, Youngren J. Regulation of glucose transport in skeletal muscle. FASEB J. 1992 Nov; 6(14):3238-44. PMID: 1426762.
      View in: PubMed
    51. Barnard RJ, Lawani LO, Martin DA, Youngren J, Singh R, Scheck SH. Effects of maturation and aging on the skeletal muscle glucose transport system. Am J Physiol. 1992 May; 262(5 Pt 1):E619-26. PMID: 1590372.
      View in: PubMed
    52. Scheck SH, Barnard RJ, Lawani LO, Youngren J, Martin DA, Singh R. Effects of NIDDM on the glucose transport system in human skeletal muscle. Diabetes Res. 1991 Mar; 16(3):111-9. PMID: 1802477.
      View in: PubMed
    53. Barnard RJ, Youngren J, Kartel DS, Martin DA. Effects of streptozotocin-induced diabetes on glucose transport in skeletal muscle. Endocrinology. 1990 Apr; 126(4):1921-6. PMID: 2138534.
      View in: PubMed
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