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Jack Youngren, PhD

TitleAssociate Adjunct Professor
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address2340 Sutter Street
San Francisco CA 94115
Phone415-476-9443
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division

    Collapse Research 
    Collapse Research Activities and Funding
    DAUs as IGF-1 Receptor Inhibitors in Breast Cancer
    NIH/NCI R01CA112042May 1, 2007 - Mar 31, 2012
    Role: Principal Investigator
    Carbonic Anhydrases in Obesity and Insulin Resistance
    NIH/NIDDK R21DK060140May 2, 2002 - Apr 30, 2005
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wyatt AW, Annala M, Aggarwal R, Beja K, Feng F, Youngren J, Foye A, Lloyd P, Nykter M, Beer TM, Alumkal JJ, Thomas GV, Reiter RE, Rettig MB, Evans CP, Gao AC, Chi KN, Small EJ, Gleave ME. Concordance of Circulating Tumor DNA and Matched Metastatic Tissue Biopsy in Prostate Cancer. J Natl Cancer Inst. 2017 Dec 01; 109(12). PMID: 29206995.
      View in: PubMed
    2. Aggarwal R, Behr SC, Paris PL, Truillet C, Parker MFL, Huynh LT, Wei J, Hann B, Youngren J, Huang J, Premasekharan G, Ranatunga N, Chang E, Gao KT, Ryan CJ, Small EJ, Evans MJ. Real-Time Transferrin-Based PET Detects MYC-Positive Prostate Cancer. Mol Cancer Res. 2017 Sep; 15(9):1221-1229. PMID: 28592703.
      View in: PubMed
    3. Holmes MG, Foss E, Joseph G, Foye A, Beckett B, Motamedi D, Youngren J, Thomas GV, Huang J, Aggarwal R, Alumkal JJ, Beer TM, Small EJ, Link TM. CT-Guided Bone Biopsies in Metastatic Castration-Resistant Prostate Cancer: Factors Predictive of Maximum Tumor Yield. J Vasc Interv Radiol. 2017 Aug; 28(8):1073-1081.e1. PMID: 28549709.
      View in: PubMed
    4. Quigley D, Alumkal JJ, Wyatt AW, Kothari V, Foye A, Lloyd P, Aggarwal R, Kim W, Lu E, Schwartzman J, Beja K, Annala M, Das R, Diolaiti M, Pritchard C, Thomas G, Tomlins S, Knudsen K, Lord CJ, Ryan C, Youngren J, Beer TM, Ashworth A, Small EJ, Feng FY. Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors. Cancer Discov. 2017 09; 7(9):999-1005. PMID: 28450426.
      View in: PubMed
    5. Podolak J, Eilers K, Newby T, Slottke R, Tucker E, Olson SB, Lue HW, Youngren J, Aggarwal R, Small EJ, Graff JN, Alumkal JJ, Beer TM, Thomas GV. Androgen receptor amplification is concordant between circulating tumor cells and biopsies from men undergoing treatment for metastatic castration resistant prostate cancer. Oncotarget. 2017 Sep 22; 8(42):71447-71455. PMID: 29069718.
      View in: PubMed
    6. Aggarwal R, Beer TM, Gleave M, Stuart JM, Rettig M, Evans CP, Youngren J, Alumkal JJ, Huang J, Thomas G, Witte O, Small EJ. Targeting Adaptive Pathways in Metastatic Treatment-Resistant Prostate Cancer: Update on the Stand Up 2 Cancer/Prostate Cancer Foundation-Supported West Coast Prostate Cancer Dream Team. Eur Urol Focus. 2016 Dec; 2(5):469-471. PMID: 28723508.
      View in: PubMed
    7. Azad AA, Volik SV, Wyatt AW, Haegert A, Le Bihan S, Bell RH, Anderson SA, McConeghy B, Shukin R, Bazov J, Youngren J, Paris P, Thomas G, Small EJ, Wang Y, Gleave ME, Collins CC, Chi KN. Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer. Clin Cancer Res. 2015 May 15; 21(10):2315-24. PMID: 25712683.
      View in: PubMed
    8. Catalano KJ, Maddux BA, Szary J, Youngren J, Goldfine ID, Schaufele F. Insulin resistance induced by hyperinsulinemia coincides with a persistent alteration at the insulin receptor tyrosine kinase domain. PLoS One. 2014; 9(9):e108693. PMID: 25259572; PMCID: PMC4178179.
    9. Masharani U, Gjerde C, McCoy S, Maddux BA, Hessler D, Goldfine ID, Youngren J. Chromium supplementation in non-obese non-diabetic subjects is associated with a decline in insulin sensitivity. BMC Endocr Disord. 2012 Nov 30; 12:31. PMID: 23194380; PMCID: PMC3537689.
    10. Troib A, Landau D, Youngren J, Kachko L, Rabkin R, Segev Y. The effects of type 1 IGF receptor inhibition in a mouse model of diabetic kidney disease. Growth Horm IGF Res. 2011 Oct; 21(5):285-91. PMID: 21865067; PMCID: PMC4238882.
    11. Masharani UB, Maddux BA, Li X, Sakkas GK, Mulligan K, Schambelan M, Goldfine ID, Youngren J. Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle. PLoS One. 2011 May 11; 6(5):e19878. PMID: 21589939; PMCID: PMC3092773.
    12. Engen W, O'Brien TE, Kelly B, Do J, Rillera L, Stapleton LK, Youngren J, Anderson MO. Synthesis of aryl-heteroaryl ureas (AHUs) based on 4-aminoquinoline and their evaluation against the insulin-like growth factor receptor (IGF-1R). Bioorg Med Chem. 2010 Aug 15; 18(16):5995-6005. PMID: 20643554; PMCID: PMC2918655.
    13. Masharani U, Gjerde C, Evans JL, Youngren J, Goldfine ID. Effects of controlled-release alpha lipoic acid in lean, nondiabetic patients with polycystic ovary syndrome. J Diabetes Sci Technol. 2010 Mar 01; 4(2):359-64. PMID: 20307398; PMCID: PMC2864173.
    14. Masharani U, Goldfine ID, Youngren J. Influence of gender on the relationship between insulin sensitivity, adiposity, and plasma lipids in lean nondiabetic subjects. Metabolism. 2009 Nov; 58(11):1602-8. PMID: 19604524; PMCID: PMC2763945.
    15. Li F, Pham JD, Anderson MO, Youngren J. Nordihydroguaiaretic acid inhibits transforming growth factor beta type 1 receptor activity and downstream signaling. Eur J Pharmacol. 2009 Aug 15; 616(1-3):31-7. PMID: 19540220; PMCID: PMC2742219.
    16. Ryan CJ, Zavodovskaya M, Youngren J, Campbell M, Diamond M, Jones J, Shiry L, Allan G, Maddux BA, Goldfine ID. Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells. Prostate. 2008 Aug 01; 68(11):1232-40. PMID: 18491370.
      View in: PubMed
    17. Zavodovskaya M, Campbell MJ, Maddux BA, Shiry L, Allan G, Hodges L, Kushner P, Kerner JA, Youngren J, Goldfine ID. Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells. J Cell Biochem. 2008 Feb 01; 103(2):624-35. PMID: 17562544.
      View in: PubMed
    18. Ryan CJ, Harzstark AH, Rosenberg J, Lin A, Claros C, Goldfine ID, Kerner JF, Small EJ, Youngren J. A pilot dose-escalation study of the effects of nordihydroguareacetic acid on hormone and prostate specific antigen levels in patients with relapsed prostate cancer. BJU Int. 2008 Feb; 101(4):436-9. PMID: 18234062.
      View in: PubMed
    19. Goldfine ID, Maddux BA, Youngren J, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L. The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities. Endocr Rev. 2008 Feb; 29(1):62-75. PMID: 18199690; PMCID: PMC2244935.
    20. Meyer GE, Chesler L, Liu D, Gable K, Maddux BA, Goldenberg DD, Youngren J, Goldfine ID, Weiss WA, Matthay KK, Rosenthal SM. Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells. J Cell Biochem. 2007 Dec 15; 102(6):1529-41. PMID: 17486636; PMCID: PMC3001106.
    21. Li X, Youngren J, Hyun B, Sakkas GK, Mulligan K, Majumdar S, Masharani UB, Schambelan M, Goldfine ID. Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T. Magn Reson Imaging. 2008 Feb; 26(2):188-97. PMID: 17683890; PMCID: PMC2713003.
    22. Blecha JE, Anderson MO, Chow JM, Guevarra CC, Pender C, Penaranda C, Zavodovskaya M, Youngren J, Berkman CE. Inhibition of IGF-1R and lipoxygenase by nordihydroguaiaretic acid (NDGA) analogs. Bioorg Med Chem Lett. 2007 Jul 15; 17(14):4026-9. PMID: 17502145; PMCID: PMC2253493.
    23. Youngren J. Regulation of insulin receptor function. Cell Mol Life Sci. 2007 Apr; 64(7-8):873-91. PMID: 17347799.
      View in: PubMed
    24. Pender C, Trentadue AR, Pories WJ, Dohm GL, Houmard JA, Youngren J. Expression of genes regulating malonyl-CoA in human skeletal muscle. J Cell Biochem. 2006 Oct 15; 99(3):860-7. PMID: 16721829.
      View in: PubMed
    25. Anderson MO, Yu H, Penaranda C, Maddux BA, Goldfine ID, Youngren J, Guy RK. Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor. J Comb Chem. 2006 Sep-Oct; 8(5):784-90. PMID: 16961415.
      View in: PubMed
    26. Gable KL, Maddux BA, Penaranda C, Zavodovskaya M, Campbell MJ, Lobo M, Robinson L, Schow S, Kerner JA, Goldfine ID, Youngren J. Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. Mol Cancer Ther. 2006 Apr; 5(4):1079-86. PMID: 16648580.
      View in: PubMed
    27. Maddux BA, Chang YN, Accili D, McGuinness OP, Youngren J, Goldfine ID. Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia. Am J Physiol Endocrinol Metab. 2006 Apr; 290(4):E746-9. PMID: 16278247.
      View in: PubMed
    28. Youngren J, Gable K, Penaranda C, Maddux BA, Zavodovskaya M, Lobo M, Campbell M, Kerner J, Goldfine ID. Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells. Breast Cancer Res Treat. 2005 Nov; 94(1):37-46. PMID: 16142439.
      View in: PubMed
    29. Pender C, Goldfine ID, Kulp JL, Tanner CJ, Maddux BA, MacDonald KG, Houmard JA, Youngren J. Analysis of insulin-stimulated insulin receptor activation and glucose transport in cultured skeletal muscle cells from obese subjects. Metabolism. 2005 May; 54(5):598-603. PMID: 15877289.
      View in: PubMed
    30. Dong H, Maddux BA, Altomonte J, Meseck M, Accili D, Terkeltaub R, Johnson K, Youngren J, Goldfine ID. Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance. Diabetes. 2005 Feb; 54(2):367-72. PMID: 15677494.
      View in: PubMed
    31. Corbould A, Kim YB, Youngren J, Pender C, Kahn BB, Lee A, Dunaif A. Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling. Am J Physiol Endocrinol Metab. 2005 May; 288(5):E1047-54. PMID: 15613682.
      View in: PubMed
    32. Evans JL, Youngren J, Goldfine ID. Effective treatments for insulin resistance: trim the fat and douse the fire. Trends Endocrinol Metab. 2004 Nov; 15(9):425-31. PMID: 15519889.
      View in: PubMed
    33. Pender C, Goldfine ID, Manchem VP, Evans JL, Spevak WR, Shi S, Rao S, Bajjalieh S, Maddux BA, Youngren J. Regulation of insulin receptor function by a small molecule insulin receptor activator. J Biol Chem. 2002 Nov 15; 277(46):43565-71. PMID: 12213804.
      View in: PubMed
    34. Li M, Youngren J, Dunaif A, Goldfine ID, Maddux BA, Zhang BB, Evans JL. Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators. J Clin Endocrinol Metab. 2002 Sep; 87(9):4088-93. PMID: 12213853.
      View in: PubMed
    35. Stefan N, Vozarova B, Funahashi T, Matsuzawa Y, Weyer C, Lindsay RS, Youngren J, Havel PJ, Pratley RE, Bogardus C, Tataranni PA. Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans. Diabetes. 2002 Jun; 51(6):1884-8. PMID: 12031977.
      View in: PubMed
    36. Pender C, Ortmeyer HK, Hansen BC, Goldfine ID, Youngren J. Elevated plasma cell membrane glycoprotein levels and diminished insulin receptor autophosphorylation in obese, insulin-resistant rhesus monkeys. Metabolism. 2002 Apr; 51(4):465-70. PMID: 11912555.
      View in: PubMed
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