Jacque Duncan, MD

Title(s)Professor, Ophthalmology
SchoolSchool of Medicine
Address490 Illinois Street
San Francisco CA 94158
Phone415-514-4241
ORCID ORCID Icon0000-0002-9593-6412 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.1995 Medicine
    University of California, San FranciscoInternship, Internal Medicine Preliminary Program1996School of Medicine
    University of California, San FranciscoOphthalmology Residency1999Ophthalmology
    Scheie Eye Institute, University of PennsylvaniaFellowship, Medical Retina and Inherited Retinal Degenerations2000Center for Hereditary Retinal Degenerations
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training
    University of California, San Francisco, CA2018Sexual Orientation and Gender Identity Training

    Collapse Overview 
    Collapse Overview
    Retinitis pigmentosa (RP) affects about 1 in 3,500 people worldwide. Age-related macular degeneration (AMD) affects as many as 1 in 4 people by the age of 75 and is the leading cause of blindness in people over age 50 in the United States. Both RP and AMD have a hereditary basis, and currently, there is no cure for either of these types of hereditary retinal degeneration. My clinical specialty is diagnosing and caring for patients with these diseases, using modalities from fluorescein angiography, to optical coherence tomography (OCT), to electroretinography (ERG).

    In both RP and AMD, loss of vision is a result of photoreceptor cell degeneration and death. Treatments that can prevent photoreceptor degeneration in experimental models of retinal degenerations may have utility in preventing degeneration in both RP and AMD. I am interested in investigating novel treatments to preserve retinal function in patients with RP, cone rod dystrophy, Stargardt disease, Best disease and AMD.

    Patients with rod specific defects undergo degeneration not only of rods, but also of cone photoreceptors. Because cones are responsible for fine visual acuity and color perception, their degeneration is particularly disabling for patients. I am interested in studying the relationship between cone photoreceptor survival and rod-specific gene defects in hereditary retinal degenerations, with the goal of preserving visual function mediated by both rods and cones.

    A major challenge in the study of retinal degenerations lies in the fact that the cells affected by these diseases, the photoreceptors and retinal pigment epithelial (RPE) cells, are not visible in the eyes of living people. My collaborator Dr. Austin Roorda at the UC Berkeley School of Optometry has developed a novel device, the adaptive optics scanning laser ophthalmoscope (AOSLO), with the ability to image individual cone photoreceptors in the central retina of living eyes. We have studied cones in patients with RP, cone-rod dystrophy and other types of retinal degeneration to better understand why vision is lost in these diseases. See Dr. Roorda’s laboratory webpage for additional details about this research.

    The UCSF Retinal Degenerations Clinic participated in 3 multi-center clinical trials for patients with inherited retinal degenerations. Two Phase II/III clinical trials evaluated the effect that a growth factor called ciliary neurotrophic factor (CNTF) has on retinal function in patients with early and late stages of RP. A Phase I study evaluated the safety and efficacy of a new generation epiretinal prosthetic device to stimulate visual perception in patients with end-stage RP. These clinical trials are among the first to study possible treatments for patients with these blinding diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Developing Cone-Dominant Retinal Disease Models as a Resource for Translational Vision Research
    NIH U24EY029891Sep 30, 2018 - Aug 31, 2023
    Role: Co-Principal Investigator
    Advanced Technology to Study Visual Function on a Cellular Scale
    NIH R01EY023591Apr 1, 2014 - Jun 30, 2024
    Role: Co-Principal Investigator
    Phase 2 Study of CNTF on Photoreceptor Structure in Retinitis Pigmentosa
    NIH R01FD004100Sep 15, 2012 - May 31, 2019
    Role: Principal Investigator
    THERAPY FOR DOMINANTLY INHERITED RETINAL DEGENERATIONS
    NIH K08EY000415Sep 1, 2000 - Aug 31, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Validation of a deep learning-based algorithm for segmentation of the ellipsoid zone on optical coherence tomography images of an USH2A-related retinal degeneration clinical trial. Retina. 2022 Feb 07. Loo J, Jaffe GJ, Duncan JL, Birch DG, Farsiu S. PMID: 35174801.
      View in: PubMed   Mentions:
    2. Choriocapillaris Changes in Myopic Macular Degeneration. Transl Vis Sci Technol. 2022 Feb 01; 11(2):37. Li J, Zhou H, Feinstein M, Wong J, Wang RK, Chan L, Dai Y, Porco T, Duncan JL, Schwartz DM. PMID: 35201337; PMCID: PMC8883151.
      View in: PubMed   Mentions:
    3. Allele-specific gene editing to rescue dominant CRX-associated LCA7 phenotypes in a retinal organoid model. Stem Cell Reports. 2021 11 09; 16(11):2690-2702. Chirco KR, Chew S, Moore AT, Duncan JL, Lamba DA. PMID: 34653402; PMCID: PMC8580887.
      View in: PubMed   Mentions:    Fields:    
    4. Correlation Between Localized Choriocapillaris Perfusion and Macular Function in Eyes with Geographic Atrophy. Am J Ophthalmol. 2022 02; 234:174-182. Rinella NT, Zhou H, Wong J, Zhang Q, Nattagh K, Porco TC, Wang RK, Schwartz DM, Duncan JL, Rinella NT, Zhou H, Wong J, Zhang Q, Nattagh K, Porco TC, Wang RK, Schwartz DM, Duncan JL. PMID: 34437870.
      View in: PubMed   Mentions:    Fields:    
    5. Macular Degeneration, Age Related. . 2021 Jun 29; 2(3):1-10. Haim HL, Duncan DJ, Zayit-Soudry ZS. .
      View in: Publisher Site   Mentions:
    6. PHENOTYPIC HETEROGENEITY IN A FAMILY WITH X-LINKED FAMILIAL EXUDATIVE VITREORETINOPATHY WITH PREVENTION OF VISUAL LOSS IN AN AFFECTED MALE CHILD WITH LASER TREATMENT IN INFANCY. Retin Cases Brief Rep. 2021 May 01; 15(3):324-329. Flores Pimentel MA, De la Huerta I, Duncan JL, Slavotinek AM, Moore AT, de Alba Campomanes AG. PMID: 30074570.
      View in: PubMed   Mentions:    Fields:    
    7. Tackling the Challenges of Product Development Through a Collaborative Rare Disease Network: The Foundation Fighting Blindness Consortium. Translational Vision Science & Technology. 2021 Apr 21; 10(4):23-23. Durham DT, Duncan DJ, Ayala AA, Birch BD, Cheetham CJ, Ferris FF, Hoyng HC, Pennesi PM, Sahel SJ, Group Gf. .
      View in: Publisher Site   Mentions:
    8. SARS-CoV-2: an occupational hazard presenting challenges for low- and middle-income countries. Int Arch Occup Environ Health. 2021 04; 94(3):565-566. Duncan JP, Figueroa JP. PMID: 33683455; PMCID: PMC7938283.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    9. The HIV epidemic in Jamaica: a need to strengthen the National HIV Program. Rev Panam Salud Publica. 2020; 44:e157. Figueroa JP, Duncan JP, Bailey A, Skyers N. PMID: 33245295; PMCID: PMC7679044.
      View in: PubMed   Mentions:    Fields:    
    10. Response to: Comment on: Dark without pressure retinal changes in a paediatric age group. Eye (Lond). 2021 11; 35(11):3173. Pimentel MAF, Duncan JL, de Alba Campomanes AG, Moore AT. PMID: 33144691; PMCID: PMC8526819.
      View in: PubMed   Mentions:    Fields:    
    11. Biallelic variants in the RNA exosome gene EXOSC5 are associated with developmental delays, short stature, cerebellar hypoplasia and motor weakness. Hum Mol Genet. 2020 08 03; 29(13):2218-2239. Slavotinek A, Misceo D, Htun S, Mathisen L, Frengen E, Foreman M, Hurtig JE, Enyenihi L, Sterrett MC, Leung SW, Schneidman-Duhovny D, Estrada-Veras J, Duncan JL, Haaxma CA, Kamsteeg EJ, Xia V, Beleford D, Si Y, Douglas G, Treidene HE, van Hoof A, Fasken MB, Corbett AH. PMID: 32504085; PMCID: PMC7399534.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    12. Dark without pressure retinal changes in a paediatric age group. Eye (Lond). 2021 Apr; 35(4):1221-1227. Flores Pimentel MA, Duncan JL, de Alba Campomanes AG, Moore A. PMID: 32690924; PMCID: PMC8115298.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. OCT Angiography to Predict Geographic Atrophy Progression using Choriocapillaris Flow Void as a Biomarker. Transl Vis Sci Technol. 2020 06; 9(7):6. Nattagh K, Zhou H, Rinella N, Zhang Q, Dai Y, Foote KG, Keiner C, Deiner M, Duncan JL, Porco TC, Wang RK, Schwartz DM. PMID: 32832213; PMCID: PMC7414606.
      View in: PubMed   Mentions: 2  Translation:Humans
    14. Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium. Translational Vision Science & Technology. 2020 Jun 3; 9(7):2-2. Thompson TD, Iannaccone IA, Ali AR, Arshavsky AV, Audo AI, Bainbridge BJ, Besirli BC, Birch BD, Branham BK, Cideciyan CA, Daiger DS, Dalkara DD, Duncan DJ, Fahim FA, Flannery FJ, Gattegna GR, Heckenlively HJ, Heon HE, Jayasundera JK, Khan KN, Klassen KH, Leroy LB, Molday MR, Musch MD, Pennesi PM, Petersen-Jones PS, Pierce PE, Rao RR, Reh RT, Sahel SJ, Sharon SD, Sieving SP, Strettoi SE, Yang YP, Zacks ZD. .
      View in: Publisher Site   Mentions:
    15. Baseline Visual Field Findings in the RUSH2A Study: Associated Factors and Correlation With Other Measures of Disease Severity. Am J Ophthalmol. 2020 11; 219:87-100. Duncan JL, Liang W, Maguire MG, Audo I, Ayala AR, Birch DG, Carroll J, Cheetham JK, Esposti SD, Durham TA, Erker L, Farsiu S, Ferris FL, Heon E, Hufnagel RB, Iannaccone A, Jaffe GJ, Kay CN, Michaelides M, Pennesi ME, Sahel JA, Foundation Fighting Blindness Consortium Investigator Group. PMID: 32446738; PMCID: PMC8596302.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Perspectives on Gene Therapy: Choroideremia Represents a Challenging Model for the Treatment of Other Inherited Retinal Degenerations. Translational Vision Science & Technology. 2020 Feb 14; 9(3):17-17. MacDonald MI, Moen MC, Duncan DJ, Tsang TS, Cehajic-Kapetanovic CJ, Aleman AT. .
      View in: Publisher Site   Mentions:
    17. Gene Therapy for Choroideremia-Progress and Remaining Questions. JAMA Ophthalmol. 2019 Nov 01; 137(11):1254-1255. Duncan JL. PMID: 31465091.
      View in: PubMed   Mentions: 1     Fields:    
    18. Quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept-source OCT angiography. Clin Ophthalmol. 2019; 13:1613-1620. Keiner CM, Zhou H, Zhang Q, Wang RK, Rinella NT, Oldenburg CE, Duncan JL, Schwartz DM. PMID: 31692580; PMCID: PMC6717151.
      View in: PubMed   Mentions: 3  
    19. Influence of eye pigmentation on retinal degeneration in P23H and S334ter mutant rhodopsin transgenic rats. Exp Eye Res. 2019 10; 187:107755. Lowe RJ, Daniello KM, Duncan JL, Yang H, Yasumura D, Matthes MT, LaVail MM. PMID: 31408630.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    20. Ciliary Neurotrophic Factor Treatment Improves Retinal Structure and Function in Macular Telangiectasia Type 2. Ophthalmology. 2019 04; 126(4):550-551. Duncan JL. PMID: 30910039.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Understanding Ocular Inflammation in Eyes Treated With Intravitreal Gene Therapy. JAMA Ophthalmol. 2019 04 01; 137(4):407. Duncan JL. PMID: 30730538.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    22. Diagnosis and Complementary Examinations. Cell-Based Therapy for Degenerative Retinal Disease. 2019 Jan 1; 193-216. Lew LY, Duncan DJ. .
      View in: Publisher Site   Mentions:
    23. Dysflective Cones. Adv Exp Med Biol. 2019; 1185:133-137. Duncan JL, Roorda A. PMID: 31884601.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    24. OCT Angiography and Cone Photoreceptor Imaging in Geographic Atrophy. Invest Ophthalmol Vis Sci. 2018 12 03; 59(15):5985-5992. Qin J, Rinella N, Zhang Q, Zhou H, Wong J, Deiner M, Roorda A, Porco TC, Wang RK, Schwartz DM, Duncan JL. PMID: 30572343; PMCID: PMC6306079.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    25. Cobalamin D Deficiency Identified Through Newborn Screening. JIMD Rep. 2019; 44:73-77. Abu-El-Haija A, Mendelsohn BA, Duncan JL, Moore AT, Glenn OA, Weisiger K, Gallagher RC. PMID: 30097992; PMCID: PMC6323031.
      View in: PubMed   Mentions: 2  
    26. Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps. Transl Vis Sci Technol. 2018 Jul; 7(4):6. Duncan JL, Pierce EA, Laster AM, Daiger SP, Birch DG, Ash JD, Iannaccone A, Flannery JG, Sahel JA, Zack DJ, Zarbin MA, and the Foundation Fighting Blindness Scientific Advisory Board. PMID: 30034950; PMCID: PMC6052953.
      View in: PubMed   Mentions: 38  
    27. High-resolution Imaging in Male Germ Cell-Associated Kinase (MAK)-related Retinal Degeneration. Am J Ophthalmol. 2018 Jan; 185:32-42. Lew YJ, Rinella N, Qin J, Chiang J, Moore AT, Porco TC, Roorda A, Duncan JL. PMID: 29103961; PMCID: PMC5732075.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    28. Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration. Exp Eye Res. 2018 02; 167:56-90. LaVail MM, Nishikawa S, Steinberg RH, Naash MI, Duncan JL, Trautmann N, Matthes MT, Yasumura D, Lau-Villacorta C, Chen J, Peterson WM, Yang H, Flannery JG. PMID: 29122605; PMCID: PMC5811379.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    29. Correction: Gustafson et al., Whole Genome Sequencing Revealed Mutations in Two Independent Genes as the Underlying Cause of Retinal Degeneration in an Ashkenazi Jewish Pedigree. Genes 2017, 8, 210. Genes (Basel). 2017 10 23; 8(10). Gustafson K, Duncan JL, Biswas P, Soto-Hermida A, Matsui H, Jakubosky D, Suk J, Telenti A, Frazer KA, Ayyagari R. PMID: 29065517; PMCID: PMC5664136.
      View in: PubMed   Mentions:    Fields:    
    30. Whole Genome Sequencing Revealed Mutations in Two Independent Genes as the Underlying Cause of Retinal Degeneration in an Ashkenazi Jewish Pedigree. Genes (Basel). 2017 08 24; 8(9). Gustafson K, Duncan JL, Biswas P, Soto-Hermida A, Matsui H, Jakubosky D, Suk J, Telenti A, Frazer KA, Ayyagari R. PMID: 28837078; PMCID: PMC5615344.
      View in: PubMed   Mentions: 6     Fields:    
    31. Dysflective cones: Visual function and cone reflectivity in long-term follow-up of acute bilateral foveolitis. Am J Ophthalmol Case Rep. 2017 Sep; 7:14-19. Tu JH, Foote KG, Lujan BJ, Ratnam K, Qin J, Gorin MB, Cunningham ET, Tuten WS, Duncan JL, Roorda A. PMID: 29057371; PMCID: PMC5644392.
      View in: PubMed   Mentions: 9  
    32. Inner retinal dystrophy in a patient with biallelic sequence variants in BRAT1. Ophthalmic Genet. 2017 12; 38(6):559-561. Oatts JT, Duncan JL, Hoyt CS, Slavotinek AM, Moore AT. PMID: 28635423.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. Visual Consequences of Delivering Therapies to the Subretinal Space. JAMA Ophthalmol. 2017 03 01; 135(3):242-243. Duncan JL. PMID: 28152125.
      View in: PubMed   Mentions: 2     Fields:    
    34. Ocular findings in a patient with fucosidosis. Am J Ophthalmol Case Rep. 2016 Dec; 4:83-86. Sánchez LR, Oatts JT, Duncan JL, Packman S, Moore AT. PMID: 29503934; PMCID: PMC5757485.
      View in: PubMed   Mentions: 2  
    35. Improvements in vision-related quality of life in blind patients implanted with the Argus II Epiretinal Prosthesis. Clin Exp Optom. 2017 Mar; 100(2):144-150. Duncan JL, Richards TP, Arditi A, da Cruz L, Dagnelie G, Dorn JD, Ho AC, Olmos de Koo LC, Barale PO, Stanga PE, Thumann G, Wang Y, Greenberg RJ. PMID: 27558213; PMCID: PMC5347867.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    36. Col4a1 mutations cause progressive retinal neovascular defects and retinopathy. Sci Rep. 2016 Jan 27; 6:18602. Alavi MV, Mao M, Pawlikowski BT, Kvezereli M, Duncan JL, Libby RT, John SW, Gould DB. PMID: 26813606; PMCID: PMC4728690.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    37. Repeatability of Cone Spacing Measures in Eyes With Inherited Retinal Degenerations. Invest Ophthalmol Vis Sci. 2015 Sep 01; 56(10):6179-89. Zayit-Soudry S, Sippl-Swezey N, Porco TC, Lynch SK, Syed R, Ratnam K, Menghini M, Roorda AJ, Duncan JL. PMID: 26416092.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    38. DIRECTIONAL OPTICAL COHERENCE TOMOGRAPHY PROVIDES ACCURATE OUTER NUCLEAR LAYER AND HENLE FIBER LAYER MEASUREMENTS. Retina. 2015 Aug; 35(8):1511-20. Lujan BJ, Roorda A, Croskrey JA, Dubis AM, Cooper RF, Bayabo JK, Duncan JL, Antony BJ, Carroll J. PMID: 25829348; PMCID: PMC4514548.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    39. Spontaneous Regeneration of Human Photoreceptor Outer Segments. Sci Rep. 2015 Jul 27; 5:12364. Horton JC, Parker AB, Botelho JV, Duncan JL. PMID: 26213154; PMCID: PMC4515765.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    40. Correlation of Serial Scleral and Corneal Pneumatonometry. Ophthalmology. 2015 Sep; 122(9):1771-6. Kuo DS, Ou Y, Jeng BH, Bhisitkul R, Stewart JM, Duncan JL, Han Y. PMID: 26165473; PMCID: PMC4549181.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    41. Adaptive optics microperimetry and OCT images show preserved function and recovery of cone visibility in macular telangiectasia type 2 retinal lesions. Invest Ophthalmol Vis Sci. 2015 Jan 13; 56(2):778-86. Wang Q, Tuten WS, Lujan BJ, Holland J, Bernstein PS, Schwartz SD, Duncan JL, Roorda A. PMID: 25587056; PMCID: PMC4315435.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    42. Correlation of outer nuclear layer thickness with cone density values in patients with retinitis pigmentosa and healthy subjects. Invest Ophthalmol Vis Sci. 2014 Dec 16; 56(1):372-81. Menghini M, Lujan BJ, Zayit-Soudry S, Syed R, Porco TC, Bayabo K, Carroll J, Roorda A, Duncan JL. PMID: 25515570; PMCID: PMC4296838.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    43. Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function. JAMA Neurol. 2014 Oct; 71(10):1228-36. Mak AC, Pullinger CR, Tang LF, Wong JS, Deo RC, Schwarz JM, Gugliucci A, Movsesyan I, Ishida BY, Chu C, Poon A, Kim P, Stock EO, Schaefer EJ, Asztalos BF, Castellano JM, Wyss-Coray T, Duncan JL, Miller BL, Kane JP, Kwok PY, Malloy MJ. PMID: 25111166; PMCID: PMC4714860.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    44. Ocular Phenotype of a Family with FAM161A-associated Retinal Degeneration. Ophthalmic Genet. 2016; 37(1):44-52. Duncan JL, Biswas P, Kozak I, Navani M, Syed R, Soudry S, Menghini M, Caruso RC, Jeffrey BG, Heckenlively JR, Reddy GB, Lee P, Roorda A, Ayyagari R. PMID: 25007332; PMCID: PMC4289132.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    45. Diagnosis and complementary examinations. Dev Ophthalmol. 2014; 53:53-69. Menghini M, Duncan JL. PMID: 24732761.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    46. Cone structure imaged with adaptive optics scanning laser ophthalmoscopy in eyes with nonneovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 2013 Nov 15; 54(12):7498-509. Zayit-Soudry S, Duncan JL, Syed R, Menghini M, Roorda AJ. PMID: 24135755; PMCID: PMC3832216.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    47. Quinacrine treatment trial for sporadic Creutzfeldt-Jakob disease. Neurology. 2013 Dec 03; 81(23):2015-23. Geschwind MD, Kuo AL, Wong KS, Haman A, Devereux G, Raudabaugh BJ, Johnson DY, Torres-Chae CC, Finley R, Garcia P, Thai JN, Cheng HQ, Neuhaus JM, Forner SA, Duncan JL, Possin KL, Dearmond SJ, Prusiner SB, Miller BL. PMID: 24122181; PMCID: PMC4211922.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    48. Relationship between foveal cone structure and clinical measures of visual function in patients with inherited retinal degenerations. Invest Ophthalmol Vis Sci. 2013 Aug 28; 54(8):5836-47. Ratnam K, Carroll J, Porco TC, Duncan JL, Roorda A. PMID: 23908179; PMCID: PMC3757906.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    49. Adaptive Optics Scanning Laser Ophthalmoscopy (AOSLO). Advanced Biophotonics. 2013 Jul 30; 20133183:507-557. Zhang ZY, Girkin GC, Duncan DJ, Roorda RA. .
      View in: Publisher Site   Mentions:
    50. High-resolution images of retinal structure in patients with choroideremia. Invest Ophthalmol Vis Sci. 2013 Feb 01; 54(2):950-61. Syed R, Sundquist SM, Ratnam K, Zayit-Soudry S, Zhang Y, Crawford JB, MacDonald IM, Godara P, Rha J, Carroll J, Roorda A, Stepien KE, Duncan JL. PMID: 23299470; PMCID: PMC3564452.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    51. Cone structure in patients with usher syndrome type III and mutations in the Clarin 1 gene. JAMA Ophthalmol. 2013 Jan; 131(1):67-74. Ratnam K, Västinsalo H, Roorda A, Sankila EM, Duncan JL. PMID: 22964989; PMCID: PMC4482614.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    52. Macular Degeneration, Age Related. eLS. 2012 Mar 15. Zayit-Soudry ZS, Duncan DJ. .
      View in: Publisher Site   Mentions:
    53. Interim results from the international trial of Second Sight's visual prosthesis. Ophthalmology. 2012 Apr; 119(4):779-88. Humayun MS, Dorn JD, da Cruz L, Dagnelie G, Sahel JA, Stanga PE, Cideciyan AV, Duncan JL, Eliott D, Filley E, Ho AC, Santos A, Safran AB, Arditi A, Del Priore LV, Greenberg RJ, Argus II Study Group. PMID: 22244176; PMCID: PMC3319859.
      View in: PubMed   Mentions: 184     Fields:    Translation:HumansCTClinical Trials
    54. Abnormal cone structure in foveal schisis cavities in X-linked retinoschisis from mutations in exon 6 of the RS1 gene. Invest Ophthalmol Vis Sci. 2011 Dec 20; 52(13):9614-23. Duncan JL, Ratnam K, Birch DG, Sundquist SM, Lucero AS, Zhang Y, Meltzer M, Smaoui N, Roorda A. PMID: 22110067; PMCID: PMC3341122.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    55. Outer retinal structure in patients with acute zonal occult outer retinopathy. Am J Ophthalmol. 2012 Apr; 153(4):757-68, 768.e1. Mkrtchyan M, Lujan BJ, Merino D, Thirkill CE, Roorda A, Duncan JL. PMID: 22105799; PMCID: PMC3288686.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    56. Growth Factor Therapy for Retinal Neuroprotection. Retinal Physician. 2011 Oct 1; 8(10):52,54,56,58,59. SYED SR, DUNCAN DJ. .
      View in: Publisher Site   Mentions:
    57. Observation of cone and rod photoreceptors in normal subjects and patients using a new generation adaptive optics scanning laser ophthalmoscope. Biomed Opt Express. 2011 Aug 01; 2(8):2189-201. Merino D, Duncan JL, Tiruveedhula P, Roorda A. PMID: 21833357; PMCID: PMC3149518.
      View in: PubMed   Mentions: 85  
    58. Cone photoreceptor abnormalities correlate with vision loss in patients with Stargardt disease. Invest Ophthalmol Vis Sci. 2011 May 17; 52(6):3281-92. Chen Y, Ratnam K, Sundquist SM, Lujan B, Ayyagari R, Gudiseva VH, Roorda A, Duncan JL. PMID: 21296825; PMCID: PMC3109028.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    59. Longitudinal study of cone photoreceptors during retinal degeneration and in response to ciliary neurotrophic factor treatment. Invest Ophthalmol Vis Sci. 2011 Apr 06; 52(5):2219-26. Talcott KE, Ratnam K, Sundquist SM, Lucero AS, Lujan BJ, Tao W, Porco TC, Roorda A, Duncan JL. PMID: 21087953; PMCID: PMC3080173.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansCellsCTClinical Trials
    60. BBS genotype-phenotype assessment of a multiethnic patient cohort calls for a revision of the disease definition. Hum Mutat. 2011 Jun; 32(6):610-9. Deveault C, Billingsley G, Duncan JL, Bin J, Theal R, Vincent A, Fieggen KJ, Gerth C, Noordeh N, Traboulsi EI, Fishman GA, Chitayat D, Knueppel T, Millán JM, Munier FL, Kennedy D, Jacobson SG, Innes AM, Mitchell GA, Boycott K, Héon E. PMID: 21344540.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    61. Cone structure in retinal degeneration associated with mutations in the peripherin/RDS gene. Invest Ophthalmol Vis Sci. 2011 Mar 01; 52(3):1557-66. Duncan JL, Talcott KE, Ratnam K, Sundquist SM, Lucero AS, Day S, Zhang Y, Roorda A. PMID: 21071739; PMCID: PMC3101697.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    62. Visual field loss in patients with cytomegalovirus retinitis. Ophthalmology. 2011 May; 118(5):895-901. Thorne JE, Van Natta ML, Jabs DA, Duncan JL, Srivastava SK, Studies of Ocular Complications of AIDS Research Group. PMID: 21146225; PMCID: PMC3087851.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    63. Adaptive optics retinal imaging: emerging clinical applications. Optom Vis Sci. 2010 Dec; 87(12):930-41. Godara P, Dubis AM, Roorda A, Duncan JL, Carroll J. PMID: 21057346; PMCID: PMC3017557.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    64. Heterogeneous patterns of tissue injury in NARP syndrome. J Neurol. 2011 Mar; 258(3):440-8. Gelfand JM, Duncan JL, Racine CA, Gillum LA, Chin CT, Zhang Y, Zhang Q, Wong LJ, Roorda A, Green AJ. PMID: 20953793; PMCID: PMC3068520.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    65. Mutations in chaperonin-like BBS genes are a major contributor to disease development in a multiethnic Bardet-Biedl syndrome patient population. J Med Genet. 2010 Jul; 47(7):453-63. Billingsley G, Bin J, Fieggen KJ, Duncan JL, Gerth C, Ogata K, Wodak SS, Traboulsi EI, Fishman GA, Paterson A, Chitayat D, Knueppel T, Millán JM, Mitchell GA, Deveault C, Héon E. PMID: 20472660.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    66. Retinal vascular abnormalities and dragged maculae in a carrier with a new NDP mutation (c.268delC) that caused severe Norrie disease in the proband. J AAPOS. 2010 Feb; 14(1):93-6. Lin P, Shankar SP, Duncan J, Slavotinek A, Stone EM, Rutar T. PMID: 20227630.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    67. Advances in imaging of Stargardt disease. Adv Exp Med Biol. 2010; 664:333-40. Chen Y, Roorda A, Duncan JL. PMID: 20238033; PMCID: PMC4862575.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    68. Phenotypic variability due to a novel Glu292Lys variation in exon 8 of the BEST1 gene causing best macular dystrophy. Arch Ophthalmol. 2009 Jul; 127(7):913-20. Sohn EH, Francis PJ, Duncan JL, Weleber RG, Saperstein DA, Farrell DF, Stone EM. PMID: 19597114; PMCID: PMC2711525.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    69. Sustained delivery of NT-3 from lens fiber cells in transgenic mice reveals specificity of neuroprotection in retinal degenerations. J Comp Neurol. 2008 Dec 20; 511(6):724-35. Lavail MM, Nishikawa S, Duncan JL, Yang H, Matthes MT, Yasumura D, Vollrath D, Overbeek PA, Ash JD, Robinson ML. PMID: 18925574; PMCID: PMC2702994.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    70. Adaptive optics scanning laser ophthalmoscopy images in a family with the mitochondrial DNA T8993C mutation. Invest Ophthalmol Vis Sci. 2009 Apr; 50(4):1838-47. Yoon MK, Roorda A, Zhang Y, Nakanishi C, Wong LJ, Zhang Q, Gillum L, Green A, Duncan JL. PMID: 18997096; PMCID: PMC4836613.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    71. Retinal TrkB receptors regulate neural development in the inner, but not outer, retina. Mol Cell Neurosci. 2008 Jul; 38(3):431-43. Grishanin RN, Yang H, Liu X, Donohue-Rolfe K, Nune GC, Zang K, Xu B, Duncan JL, Lavail MM, Copenhagen DR, Reichardt LF. PMID: 18511296; PMCID: PMC2849660.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    72. Intraocular CNTF reduces vision in normal rats in a dose-dependent manner. Invest Ophthalmol Vis Sci. 2007 Dec; 48(12):5756-66. McGill TJ, Prusky GT, Douglas RM, Yasumura D, Matthes MT, Nune G, Donohue-Rolfe K, Yang H, Niculescu D, Hauswirth WW, Girman SV, Lund RD, Duncan JL, LaVail MM. PMID: 18055829.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCellsPHPublic Health
    73. Rapid and stable knockdown of an endogenous gene in retinal pigment epithelium. Hum Gene Ther. 2007 Oct; 18(10):871-80. Paskowitz DM, Greenberg KP, Yasumura D, Grimm D, Yang H, Duncan JL, Kay MA, Lavail MM, Flannery JG, Vollrath D. PMID: 17892416.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    74. Vesicular glutamate transporter 1 is required for photoreceptor synaptic signaling but not for intrinsic visual functions. J Neurosci. 2007 Jul 04; 27(27):7245-55. Johnson J, Fremeau RT, Duncan JL, Rentería RC, Yang H, Hua Z, Liu X, LaVail MM, Edwards RH, Copenhagen DR. PMID: 17611277; PMCID: PMC2443709.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    75. High-resolution imaging with adaptive optics in patients with inherited retinal degeneration. Invest Ophthalmol Vis Sci. 2007 Jul; 48(7):3283-91. Duncan JL, Zhang Y, Gandhi J, Nakanishi C, Othman M, Branham KE, Swaroop A, Roorda A. PMID: 17591900.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansCells
    76. High-resolution in vivo imaging of the RPE mosaic in eyes with retinal disease. Invest Ophthalmol Vis Sci. 2007 May; 48(5):2297-303. Roorda A, Zhang Y, Duncan JL. PMID: 17460294.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    77. Molecular and cellular alterations induced by sustained expression of ciliary neurotrophic factor in a mouse model of retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2007 Mar; 48(3):1389-400. Rhee KD, Ruiz A, Duncan JL, Hauswirth WW, Lavail MM, Bok D, Yang XJ. PMID: 17325188; PMCID: PMC7147570.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    78. Neurotrophic factors minimize the retinal toxicity of verteporfin photodynamic therapy. Invest Ophthalmol Vis Sci. 2007 Jan; 48(1):430-7. Paskowitz DM, Donohue-Rolfe KM, Yang H, Yasumura D, Matthes MT, Hosseini K, Graybeal CM, Nune G, Zarbin MA, Lavail MM, Duncan JL. PMID: 17197564.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    79. Factors affecting attrition in a longitudinal study of patients with AIDS. AIDS Care. 2006 Oct; 18(7):821-9. Brown DM, Thorne JE, Foster GL, Duncan JL, Brune LM, Muñana A, Meinert CL, Jabs DA. PMID: 16971294.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    80. Scotopic visual signaling in the mouse retina is modulated by high-affinity plasma membrane calcium extrusion. J Neurosci. 2006 Jul 05; 26(27):7201-11. Duncan JL, Yang H, Doan T, Silverstein RS, Murphy GJ, Nune G, Liu X, Copenhagen D, Tempel BL, Rieke F, Krizaj D. PMID: 16822977; PMCID: PMC1987386.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    81. Correlation between clinical suspicion and polymerase chain reaction verification of infectious vitritis. Am J Ophthalmol. 2006 Mar; 141(3):584-5. Acharya N, Lietman T, Cevallos V, Whitcher JP, Saidel M, Stone D, Duncan J, Margolis TP. PMID: 16490520.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    82. Retinal damage caused by photodynamic therapy can be reduced using BDNF. Adv Exp Med Biol. 2006; 572:297-302. Duncan JL, Paskowitz DM, Nune GC, Yasumura D, Yang H, Matthes MT, Zarbin MA, LaVail MM. PMID: 17249587.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    83. Preface. International Ophthalmology Clinics. 2006 Jan 1; 47(1):xiii-xiv. Duncan DJ, Palmer PJ. .
      View in: Publisher Site   Mentions:
    84. Mouse models may provide new insight into the relation between cholesterol and age related macular degeneration. Br J Ophthalmol. 2005 Dec; 89(12):1549-51. Duncan JL. PMID: 16299127; PMCID: PMC1772982.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    85. Macular schisis detachment associated with angle-closure glaucoma. Arch Ophthalmol. 2005 Feb; 123(2):270-2. Hollander DA, Barricks ME, Duncan JL, Irvine AR. PMID: 15710832.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    86. Bilateral endogenous Scedosporium prolificans endophthalmitis after lung transplantation. Am J Ophthalmol. 2005 Feb; 139(2):370-3. Vagefi MR, Kim ET, Alvarado RG, Duncan JL, Howes EL, Crawford JB. PMID: 15734012.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    87. Acute zonal occult outer retinopathy in a patient with graft-versus-host disease. Am J Ophthalmol. 2004 Dec; 138(6):1058-60. Cheung MC, Nune GC, Hwang DG, Sutter EE, Duncan JL. PMID: 15629309.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    88. Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia. Hum Mol Genet. 2005 Jan 01; 14(1):49-57. Kuo YM, Duncan JL, Westaway SK, Yang H, Nune G, Xu EY, Hayflick SJ, Gitschier J. PMID: 15525657; PMCID: PMC2117329.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimals
    89. BDNF reduces the retinal toxicity of verteporfin photodynamic therapy. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):4190-6. Paskowitz DM, Nune G, Yasumura D, Yang H, Bhisitkul RB, Sharma S, Matthes MT, Zarbin MA, Lavail MM, Duncan JL. PMID: 15505074.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    90. Statin and aspirin therapy are associated with decreased rates of choroidal neovascularization among patients with age-related macular degeneration. Am J Ophthalmol. 2004 Apr; 137(4):615-24. Wilson HL, Schwartz DM, Bhatt HR, McCulloch CE, Duncan JL. PMID: 15059698.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    91. Detection of localized retinal dysfunction in a choroideremia carrier. Am J Ophthalmol. 2004 Jan; 137(1):189-91. Cheung MC, Nune GC, Wang M, McTaggart KE, MacDonald IM, Duncan JL. PMID: 14700671.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    92. An RCS-like retinal dystrophy phenotype in mer knockout mice. Invest Ophthalmol Vis Sci. 2003 Feb; 44(2):826-38. Duncan JL, LaVail MM, Yasumura D, Matthes MT, Yang H, Trautmann N, Chappelow AV, Feng W, Earp HS, Matsushima GK, Vollrath D. PMID: 12556419.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    93. Macular Degeneration, Age Related. eLS. 2003 Jan 29. Duncan DJ, Berger BJ, Fine FS. .
      View in: Publisher Site   Mentions:
    94. Inherited retinal dystrophy in Mer knockout mice. Adv Exp Med Biol. 2003; 533:165-72. Duncan JL, Yang H, Vollrath D, Yasumura D, Matthes MT, Trautmann N, Chappelow AV, Feng W, Earp HS, Matsushima GK, LaVail MM. PMID: 15180261.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    95. Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation. Exp Eye Res. 2002 Jun; 74(6):719-35. Bok D, Yasumura D, Matthes MT, Ruiz A, Duncan JL, Chappelow AV, Zolutukhin S, Hauswirth W, LaVail MM. PMID: 12126945.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    96. Macular pigment and lutein supplementation in choroideremia. Exp Eye Res. 2002 Mar; 74(3):371-81. Duncan JL, Aleman TS, Gardner LM, De Castro E, Marks DA, Emmons JM, Bieber ML, Steinberg JD, Bennett J, Stone EM, MacDonald IM, Cideciyan AV, Maguire MG, Jacobson SG. PMID: 12014918.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCellsCTClinical Trials
    97. Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12584-9. Vollrath D, Feng W, Duncan JL, Yasumura D, D'Cruz PM, Chappelow A, Matthes MT, Kay MA, LaVail MM. PMID: 11592982; PMCID: PMC60097.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    98. Macular pigment and lutein supplementation in retinitis pigmentosa and Usher syndrome. Invest Ophthalmol Vis Sci. 2001 Jul; 42(8):1873-81. Aleman TS, Duncan JL, Bieber ML, de Castro E, Marks DA, Gardner LM, Steinberg JD, Cideciyan AV, Maguire MG, Jacobson SG. PMID: 11431456.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    99. Linear nevus sebaceous syndrome: Authors’ reply. Ophthalmology. 1999 Feb 1; 106(2):207. Duncan DJ, Cunningham CE. .
      View in: Publisher Site   Mentions:
    100. 6-substituted tricyclic partial ergoline compounds are selective and potent 5-hydroxytryptamine1A receptor agents. Life Sci. 1990; 47(15):1331-7. Slaughter JL, Harrington MA, Peroutka SJ. PMID: 2172684.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
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