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Jacque Duncan, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentOphthalmology
Address10 Koret Way
San Francisco CA 94143
Phone415-514-4241
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.1995 Medicine
    University of California, San FranciscoInternship, Internal Medicine Preliminary Program1996School of Medicine
    University of California, San FranciscoOphthalmology Residency1999Ophthalmology
    Scheie Eye Institute, University of PennsylvaniaFellowship, Medical Retina and Inherited Retinal Degenerations2000Center for Hereditary Retinal Degenerations

    Collapse Overview 
    Collapse Overview
    Retinitis pigmentosa (RP) affects about 1 in 3,500 people worldwide. Age-related macular degeneration (AMD) affects as many as 1 in 4 people by the age of 75 and is the leading cause of blindness in people over age 50 in the United States. Both RP and AMD have a hereditary basis, and currently, there is no cure for either of these types of hereditary retinal degeneration. My clinical specialty is diagnosing and caring for patients with these diseases, using modalities from fluorescein angiography, to optical coherence tomography (OCT), to electroretinography (ERG).

    In both RP and AMD, loss of vision is a result of photoreceptor cell degeneration and death. Treatments that can prevent photoreceptor degeneration in experimental models of retinal degenerations may have utility in preventing degeneration in both RP and AMD. I am interested in investigating novel treatments to preserve retinal function in patients with RP, cone rod dystrophy, Stargardt disease, Best disease and AMD.

    Patients with rod specific defects undergo degeneration not only of rods, but also of cone photoreceptors. Because cones are responsible for fine visual acuity and color perception, their degeneration is particularly disabling for patients. I am interested in studying the relationship between cone photoreceptor survival and rod-specific gene defects in hereditary retinal degenerations, with the goal of preserving visual function mediated by both rods and cones.

    A major challenge in the study of retinal degenerations lies in the fact that the cells affected by these diseases, the photoreceptors and retinal pigment epithelial (RPE) cells, are not visible in the eyes of living people. My collaborator Dr. Austin Roorda at the UC Berkeley School of Optometry has developed a novel device, the adaptive optics scanning laser ophthalmoscope (AOSLO), with the ability to image individual cone photoreceptors in the central retina of living eyes. We have studied cones in patients with RP, cone-rod dystrophy and other types of retinal degeneration to better understand why vision is lost in these diseases. See Dr. Roorda’s laboratory webpage for additional details about this research.

    The UCSF Retinal Degenerations Clinic participated in 3 multi-center clinical trials for patients with inherited retinal degenerations. Two Phase II/III clinical trials evaluated the effect that a growth factor called ciliary neurotrophic factor (CNTF) has on retinal function in patients with early and late stages of RP. A Phase I study evaluated the safety and efficacy of a new generation epiretinal prosthetic device to stimulate visual perception in patients with end-stage RP. These clinical trials are among the first to study possible treatments for patients with these blinding diseases.


    Collapse Research 
    Collapse Research Activities and Funding
    Advanced Technology to Study Visual Function on a Cellular Scale
    NIH/NEI R01EY023591Apr 1, 2014 - Mar 31, 2019
    Role: Co-Principal Investigator
    Phase 2 Study of CNTF on Photoreceptor Structure in Retinitis Pigmentosa
    FDA R01FD004100Sep 15, 2012 - May 31, 2019
    Role: Principal Investigator
    THERAPY FOR DOMINANTLY INHERITED RETINAL DEGENERATIONS
    NIH/NEI K08EY000415Sep 1, 2000 - Aug 31, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Flores Pimentel MA, De la Huerta I, Duncan J, Slavotinek AM, Moore AT, de Alba Campomanes AG. PHENOTYPIC HETEROGENEITY IN A FAMILY WITH X-LINKED FAMILIAL EXUDATIVE VITREORETINOPATHY WITH PREVENTION OF VISUAL LOSS IN AN AFFECTED MALE CHILD WITH LASER TREATMENT IN INFANCY. Retin Cases Brief Rep. 2018 Aug 01. PMID: 30074570.
      View in: PubMed
    2. Duncan J, Pierce EA, Laster AM, Daiger SP, Birch DG, Ash JD, Iannaccone A, Flannery JG, Sahel JA, Zack DJ, Zarbin MA. Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps. Transl Vis Sci Technol. 2018 Jul; 7(4):6. PMID: 30034950.
      View in: PubMed
    3. Lew YJ, Rinella N, Qin J, Chiang J, Moore AT, Porco TC, Roorda A, Duncan J. High-resolution Imaging in Male Germ Cell-Associated Kinase (MAK)-related Retinal Degeneration. Am J Ophthalmol. 2018 Jan; 185:32-42. PMID: 29103961.
      View in: PubMed
    4. LaVail MM, Nishikawa S, Steinberg RH, Naash MI, Duncan J, Trautmann N, Matthes MT, Yasumura D, Lau-Villacorta C, Chen J, Peterson WM, Yang H, Flannery JG. Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration. Exp Eye Res. 2018 Feb; 167:56-90. PMID: 29122605.
      View in: PubMed
    5. Gustafson K, Duncan J, Biswas P, Soto-Hermida A, Matsui H, Jakubosky D, Suk J, Telenti A, Frazer KA, Ayyagari R. Correction: Gustafson et al., Whole Genome Sequencing Revealed Mutations in Two Independent Genes as the Underlying Cause of Retinal Degeneration in an Ashkenazi Jewish Pedigree. Genes 2017, 8, 210. Genes (Basel). 2017 Oct 23; 8(10). PMID: 29065517.
      View in: PubMed
    6. Gustafson K, Duncan J, Biswas P, Soto-Hermida A, Matsui H, Jakubosky D, Suk J, Telenti A, Frazer KA, Ayyagari R. Whole Genome Sequencing Revealed Mutations in Two Independent Genes as the Underlying Cause of Retinal Degeneration in an Ashkenazi Jewish Pedigree. Genes (Basel). 2017 Aug 24; 8(9). PMID: 28837078.
      View in: PubMed
    7. Tu JH, Foote KG, Lujan BJ, Ratnam K, Qin J, Gorin MB, Cunningham ET, Tuten WS, Duncan J, Roorda A. Dysflective cones: Visual function and cone reflectivity in long-term follow-up of acute bilateral foveolitis. Am J Ophthalmol Case Rep. 2017 Sep; 7:14-19. PMID: 29057371.
      View in: PubMed
    8. Oatts JT, Duncan J, Hoyt CS, Slavotinek AM, Moore AT. Inner retinal dystrophy in a patient with biallelic sequence variants in BRAT1. Ophthalmic Genet. 2017 12; 38(6):559-561. PMID: 28635423.
      View in: PubMed
    9. Duncan J. Visual Consequences of Delivering Therapies to the Subretinal Space. JAMA Ophthalmol. 2017 Mar 01; 135(3):242-243. PMID: 28152125.
      View in: PubMed
    10. Sánchez LR, Oatts JT, Duncan J, Packman S, Moore AT. Ocular findings in a patient with fucosidosis. Am J Ophthalmol Case Rep. 2016 Dec; 4:83-86. PMID: 29503934.
      View in: PubMed
    11. Duncan J, Richards TP, Arditi A, da Cruz L, Dagnelie G, Dorn JD, Ho AC, Olmos de Koo LC, Barale PO, Stanga PE, Thumann G, Wang Y, Greenberg RJ. Improvements in vision-related quality of life in blind patients implanted with the Argus II Epiretinal Prosthesis. Clin Exp Optom. 2017 Mar; 100(2):144-150. PMID: 27558213.
      View in: PubMed
    12. Alavi MV, Mao M, Pawlikowski BT, Kvezereli M, Duncan J, Libby RT, John SW, Gould DB. Col4a1 mutations cause progressive retinal neovascular defects and retinopathy. Sci Rep. 2016 Jan 27; 6:18602. PMID: 26813606; PMCID: PMC4728690.
      View in: PubMed, PubMed Central
    13. Zayit-Soudry S, Sippl-Swezey N, Porco TC, Lynch SK, Syed R, Ratnam K, Menghini M, Roorda AJ, Duncan J. Repeatability of Cone Spacing Measures in Eyes With Inherited Retinal Degenerations. Invest Ophthalmol Vis Sci. 2015 Sep 01; 56(10):6179-89. PMID: 26416092.
      View in: PubMed
    14. Lujan BJ, Roorda A, Croskrey JA, Dubis AM, Cooper RF, Bayabo JK, Duncan J, Antony BJ, Carroll J. DIRECTIONAL OPTICAL COHERENCE TOMOGRAPHY PROVIDES ACCURATE OUTER NUCLEAR LAYER AND HENLE FIBER LAYER MEASUREMENTS. Retina. 2015 Aug; 35(8):1511-20. PMID: 25829348; PMCID: PMC4514548.
      View in: PubMed, PubMed Central
    15. Horton JC, Parker AB, Botelho JV, Duncan J. Spontaneous Regeneration of Human Photoreceptor Outer Segments. Sci Rep. 2015 Jul 27; 5:12364. PMID: 26213154; PMCID: PMC4515765.
      View in: PubMed, PubMed Central
    16. Kuo DS, Ou Y, Jeng BH, Bhisitkul R, Stewart JM, Duncan J, Han Y. Correlation of Serial Scleral and Corneal Pneumatonometry. Ophthalmology. 2015 Sep; 122(9):1771-6. PMID: 26165473; PMCID: PMC4549181.
      View in: PubMed, PubMed Central
    17. Wang Q, Tuten WS, Lujan BJ, Holland J, Bernstein PS, Schwartz SD, Duncan J, Roorda A. Adaptive optics microperimetry and OCT images show preserved function and recovery of cone visibility in macular telangiectasia type 2 retinal lesions. Invest Ophthalmol Vis Sci. 2015 Jan 13; 56(2):778-86. PMID: 25587056; PMCID: PMC4315435.
      View in: PubMed, PubMed Central
    18. Menghini M, Lujan BJ, Zayit-Soudry S, Syed R, Porco TC, Bayabo K, Carroll J, Roorda A, Duncan J. Correlation of outer nuclear layer thickness with cone density values in patients with retinitis pigmentosa and healthy subjects. Invest Ophthalmol Vis Sci. 2014 Dec 16; 56(1):372-81. PMID: 25515570; PMCID: PMC4296838.
      View in: PubMed, PubMed Central
    19. Mak AC, Pullinger CR, Tang LF, Wong JS, Deo RC, Schwarz JM, Gugliucci A, Movsesyan I, Ishida BY, Chu C, Poon A, Kim P, Stock EO, Schaefer EJ, Asztalos BF, Castellano JM, Wyss-Coray T, Duncan J, Miller BL, Kane JP, Kwok PY, Malloy MJ. Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function. JAMA Neurol. 2014 Oct; 71(10):1228-36. PMID: 25111166; PMCID: PMC4714860.
      View in: PubMed, PubMed Central
    20. Duncan J, Biswas P, Kozak I, Navani M, Syed R, Soudry S, Menghini M, Caruso RC, Jeffrey BG, Heckenlively JR, Reddy GB, Lee P, Roorda A, Ayyagari R. Ocular Phenotype of a Family with FAM161A-associated Retinal Degeneration. Ophthalmic Genet. 2016; 37(1):44-52. PMID: 25007332; PMCID: PMC4289132.
      View in: PubMed, PubMed Central
    21. Menghini M, Duncan J. Diagnosis and complementary examinations. Dev Ophthalmol. 2014; 53:53-69. PMID: 24732761.
      View in: PubMed
    22. Weir SS, Figueroa JP, Byfield LL, Scott MA, Hobbs MM, Edwards JE, Duncan J. "Do you think your main partner has other sex partners?" A simple question provides insight into sexual risk in Jamaica. Int J STD AIDS. 2015 Jan; 26(1):37-41. PMID: 24695013; PMCID: PMC4652656.
      View in: PubMed, PubMed Central
    23. Zayit-Soudry S, Duncan J, Syed R, Menghini M, Roorda AJ. Cone structure imaged with adaptive optics scanning laser ophthalmoscopy in eyes with nonneovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 2013 Nov 15; 54(12):7498-509. PMID: 24135755; PMCID: PMC3832216.
      View in: PubMed, PubMed Central
    24. Geschwind MD, Kuo AL, Wong KS, Haman A, Devereux G, Raudabaugh BJ, Johnson DY, Torres-Chae CC, Finley R, Garcia P, Thai JN, Cheng HQ, Neuhaus JM, Forner SA, Duncan J, Possin KL, Dearmond SJ, Prusiner SB, Miller BL. Quinacrine treatment trial for sporadic Creutzfeldt-Jakob disease. Neurology. 2013 Dec 03; 81(23):2015-23. PMID: 24122181; PMCID: PMC4211922.
      View in: PubMed, PubMed Central
    25. Ratnam K, Carroll J, Porco TC, Duncan J, Roorda A. Relationship between foveal cone structure and clinical measures of visual function in patients with inherited retinal degenerations. Invest Ophthalmol Vis Sci. 2013 Aug 28; 54(8):5836-47. PMID: 23908179; PMCID: PMC3757906.
      View in: PubMed, PubMed Central
    26. Syed R, Sundquist SM, Ratnam K, Zayit-Soudry S, Zhang Y, Crawford JB, MacDonald IM, Godara P, Rha J, Carroll J, Roorda A, Stepien KE, Duncan J. High-resolution images of retinal structure in patients with choroideremia. Invest Ophthalmol Vis Sci. 2013 Feb 01; 54(2):950-61. PMID: 23299470; PMCID: PMC3564452.
      View in: PubMed, PubMed Central
    27. Ratnam K, Västinsalo H, Roorda A, Sankila EM, Duncan J. Cone structure in patients with usher syndrome type III and mutations in the Clarin 1 gene. JAMA Ophthalmol. 2013 Jan; 131(1):67-74. PMID: 22964989; PMCID: PMC4482614.
      View in: PubMed, PubMed Central
    28. Humayun MS, Dorn JD, da Cruz L, Dagnelie G, Sahel JA, Stanga PE, Cideciyan AV, Duncan J, Eliott D, Filley E, Ho AC, Santos A, Safran AB, Arditi A, Del Priore LV, Greenberg RJ. Interim results from the international trial of Second Sight's visual prosthesis. Ophthalmology. 2012 Apr; 119(4):779-88. PMID: 22244176; PMCID: PMC3319859.
      View in: PubMed, PubMed Central
    29. Duncan J, Ratnam K, Birch DG, Sundquist SM, Lucero AS, Zhang Y, Meltzer M, Smaoui N, Roorda A. Abnormal cone structure in foveal schisis cavities in X-linked retinoschisis from mutations in exon 6 of the RS1 gene. Invest Ophthalmol Vis Sci. 2011 Dec 20; 52(13):9614-23. PMID: 22110067; PMCID: PMC3341122.
      View in: PubMed, PubMed Central
    30. Mkrtchyan M, Lujan BJ, Merino D, Thirkill CE, Roorda A, Duncan J. Outer retinal structure in patients with acute zonal occult outer retinopathy. Am J Ophthalmol. 2012 Apr; 153(4):757-68, 768.e1. PMID: 22105799; PMCID: PMC3288686.
      View in: PubMed, PubMed Central
    31. Merino D, Duncan J, Tiruveedhula P, Roorda A. Observation of cone and rod photoreceptors in normal subjects and patients using a new generation adaptive optics scanning laser ophthalmoscope. Biomed Opt Express. 2011 Aug 01; 2(8):2189-201. PMID: 21833357; PMCID: PMC3149518.
      View in: PubMed, PubMed Central
    32. Chen Y, Ratnam K, Sundquist SM, Lujan B, Ayyagari R, Gudiseva VH, Roorda A, Duncan J. Cone photoreceptor abnormalities correlate with vision loss in patients with Stargardt disease. Invest Ophthalmol Vis Sci. 2011 May 17; 52(6):3281-92. PMID: 21296825; PMCID: PMC3109028.
      View in: PubMed, PubMed Central
    33. Talcott KE, Ratnam K, Sundquist SM, Lucero AS, Lujan BJ, Tao W, Porco TC, Roorda A, Duncan J. Longitudinal study of cone photoreceptors during retinal degeneration and in response to ciliary neurotrophic factor treatment. Invest Ophthalmol Vis Sci. 2011 Apr 06; 52(5):2219-26. PMID: 21087953; PMCID: PMC3080173.
      View in: PubMed, PubMed Central
    34. Deveault C, Billingsley G, Duncan J, Bin J, Theal R, Vincent A, Fieggen KJ, Gerth C, Noordeh N, Traboulsi EI, Fishman GA, Chitayat D, Knueppel T, Millán JM, Munier FL, Kennedy D, Jacobson SG, Innes AM, Mitchell GA, Boycott K, Héon E. BBS genotype-phenotype assessment of a multiethnic patient cohort calls for a revision of the disease definition. Hum Mutat. 2011 Jun; 32(6):610-9. PMID: 21344540.
      View in: PubMed
    35. Duncan J, Talcott KE, Ratnam K, Sundquist SM, Lucero AS, Day S, Zhang Y, Roorda A. Cone structure in retinal degeneration associated with mutations in the peripherin/RDS gene. Invest Ophthalmol Vis Sci. 2011 Mar 01; 52(3):1557-66. PMID: 21071739; PMCID: PMC3101697.
      View in: PubMed, PubMed Central
    36. Thorne JE, Van Natta ML, Jabs DA, Duncan J, Srivastava SK. Visual field loss in patients with cytomegalovirus retinitis. Ophthalmology. 2011 May; 118(5):895-901. PMID: 21146225; PMCID: PMC3087851.
      View in: PubMed, PubMed Central
    37. Godara P, Dubis AM, Roorda A, Duncan J, Carroll J. Adaptive optics retinal imaging: emerging clinical applications. Optom Vis Sci. 2010 Dec; 87(12):930-41. PMID: 21057346; PMCID: PMC3017557.
      View in: PubMed, PubMed Central
    38. Gelfand JM, Duncan J, Racine CA, Gillum LA, Chin CT, Zhang Y, Zhang Q, Wong LJ, Roorda A, Green AJ. Heterogeneous patterns of tissue injury in NARP syndrome. J Neurol. 2011 Mar; 258(3):440-8. PMID: 20953793; PMCID: PMC3068520.
      View in: PubMed, PubMed Central
    39. Billingsley G, Bin J, Fieggen KJ, Duncan J, Gerth C, Ogata K, Wodak SS, Traboulsi EI, Fishman GA, Paterson A, Chitayat D, Knueppel T, Millán JM, Mitchell GA, Deveault C, Héon E. Mutations in chaperonin-like BBS genes are a major contributor to disease development in a multiethnic Bardet-Biedl syndrome patient population. J Med Genet. 2010 Jul; 47(7):453-63. PMID: 20472660.
      View in: PubMed
    40. Lin P, Shankar SP, Duncan J, Slavotinek A, Stone EM, Rutar T. Retinal vascular abnormalities and dragged maculae in a carrier with a new NDP mutation (c.268delC) that caused severe Norrie disease in the proband. J AAPOS. 2010 Feb; 14(1):93-6. PMID: 20227630.
      View in: PubMed
    41. Chen Y, Roorda A, Duncan J. Advances in imaging of Stargardt disease. Adv Exp Med Biol. 2010; 664:333-40. PMID: 20238033; PMCID: PMC4862575.
      View in: PubMed, PubMed Central
    42. Sohn EH, Francis PJ, Duncan J, Weleber RG, Saperstein DA, Farrell DF, Stone EM. Phenotypic variability due to a novel Glu292Lys variation in exon 8 of the BEST1 gene causing best macular dystrophy. Arch Ophthalmol. 2009 Jul; 127(7):913-20. PMID: 19597114; PMCID: PMC2711525.
      View in: PubMed, PubMed Central
    43. Lavail MM, Nishikawa S, Duncan J, Yang H, Matthes MT, Yasumura D, Vollrath D, Overbeek PA, Ash JD, Robinson ML. Sustained delivery of NT-3 from lens fiber cells in transgenic mice reveals specificity of neuroprotection in retinal degenerations. J Comp Neurol. 2008 Dec 20; 511(6):724-35. PMID: 18925574; PMCID: PMC2702994.
      View in: PubMed, PubMed Central
    44. Yoon MK, Roorda A, Zhang Y, Nakanishi C, Wong LJ, Zhang Q, Gillum L, Green A, Duncan J. Adaptive optics scanning laser ophthalmoscopy images in a family with the mitochondrial DNA T8993C mutation. Invest Ophthalmol Vis Sci. 2009 Apr; 50(4):1838-47. PMID: 18997096; PMCID: PMC4836613.
      View in: PubMed, PubMed Central
    45. Grishanin RN, Yang H, Liu X, Donohue-Rolfe K, Nune GC, Zang K, Xu B, Duncan J, Lavail MM, Copenhagen DR, Reichardt LF. Retinal TrkB receptors regulate neural development in the inner, but not outer, retina. Mol Cell Neurosci. 2008 Jul; 38(3):431-43. PMID: 18511296; PMCID: PMC2849660.
      View in: PubMed, PubMed Central
    46. McGill TJ, Prusky GT, Douglas RM, Yasumura D, Matthes MT, Nune G, Donohue-Rolfe K, Yang H, Niculescu D, Hauswirth WW, Girman SV, Lund RD, Duncan J, LaVail MM. Intraocular CNTF reduces vision in normal rats in a dose-dependent manner. Invest Ophthalmol Vis Sci. 2007 Dec; 48(12):5756-66. PMID: 18055829.
      View in: PubMed
    47. Paskowitz DM, Greenberg KP, Yasumura D, Grimm D, Yang H, Duncan J, Kay MA, Lavail MM, Flannery JG, Vollrath D. Rapid and stable knockdown of an endogenous gene in retinal pigment epithelium. Hum Gene Ther. 2007 Oct; 18(10):871-80. PMID: 17892416.
      View in: PubMed
    48. Johnson J, Fremeau RT, Duncan J, Rentería RC, Yang H, Hua Z, Liu X, LaVail MM, Edwards RH, Copenhagen DR. Vesicular glutamate transporter 1 is required for photoreceptor synaptic signaling but not for intrinsic visual functions. J Neurosci. 2007 Jul 04; 27(27):7245-55. PMID: 17611277; PMCID: PMC2443709.
      View in: PubMed, PubMed Central
    49. Duncan J, Zhang Y, Gandhi J, Nakanishi C, Othman M, Branham KE, Swaroop A, Roorda A. High-resolution imaging with adaptive optics in patients with inherited retinal degeneration. Invest Ophthalmol Vis Sci. 2007 Jul; 48(7):3283-91. PMID: 17591900.
      View in: PubMed
    50. Roorda A, Zhang Y, Duncan J. High-resolution in vivo imaging of the RPE mosaic in eyes with retinal disease. Invest Ophthalmol Vis Sci. 2007 May; 48(5):2297-303. PMID: 17460294.
      View in: PubMed
    51. Rhee KD, Ruiz A, Duncan J, Hauswirth WW, Lavail MM, Bok D, Yang XJ. Molecular and cellular alterations induced by sustained expression of ciliary neurotrophic factor in a mouse model of retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2007 Mar; 48(3):1389-400. PMID: 17325188.
      View in: PubMed
    52. Paskowitz DM, Donohue-Rolfe KM, Yang H, Yasumura D, Matthes MT, Hosseini K, Graybeal CM, Nune G, Zarbin MA, Lavail MM, Duncan J. Neurotrophic factors minimize the retinal toxicity of verteporfin photodynamic therapy. Invest Ophthalmol Vis Sci. 2007 Jan; 48(1):430-7. PMID: 17197564.
      View in: PubMed
    53. Brown DM, Thorne JE, Foster GL, Duncan J, Brune LM, Muñana A, Meinert CL, Jabs DA. Factors affecting attrition in a longitudinal study of patients with AIDS. AIDS Care. 2006 Oct; 18(7):821-9. PMID: 16971294.
      View in: PubMed
    54. Duncan J, Yang H, Doan T, Silverstein RS, Murphy GJ, Nune G, Liu X, Copenhagen D, Tempel BL, Rieke F, Krizaj D. Scotopic visual signaling in the mouse retina is modulated by high-affinity plasma membrane calcium extrusion. J Neurosci. 2006 Jul 05; 26(27):7201-11. PMID: 16822977; PMCID: PMC1987386.
      View in: PubMed, PubMed Central
    55. Acharya N, Lietman T, Cevallos V, Whitcher JP, Saidel M, Stone D, Duncan J, Margolis TP. Correlation between clinical suspicion and polymerase chain reaction verification of infectious vitritis. Am J Ophthalmol. 2006 Mar; 141(3):584-5. PMID: 16490520.
      View in: PubMed
    56. Duncan J, Paskowitz DM, Nune GC, Yasumura D, Yang H, Matthes MT, Zarbin MA, LaVail MM. Retinal damage caused by photodynamic therapy can be reduced using BDNF. Adv Exp Med Biol. 2006; 572:297-302. PMID: 17249587.
      View in: PubMed
    57. Duncan J. Mouse models may provide new insight into the relation between cholesterol and age related macular degeneration. Br J Ophthalmol. 2005 Dec; 89(12):1549-51. PMID: 16299127; PMCID: PMC1772982.
      View in: PubMed, PubMed Central
    58. Vagefi MR, Kim ET, Alvarado RG, Duncan J, Howes EL, Crawford JB. Bilateral endogenous Scedosporium prolificans endophthalmitis after lung transplantation. Am J Ophthalmol. 2005 Feb; 139(2):370-3. PMID: 15734012.
      View in: PubMed
    59. Hollander DA, Barricks ME, Duncan J, Irvine AR. Macular schisis detachment associated with angle-closure glaucoma. Arch Ophthalmol. 2005 Feb; 123(2):270-2. PMID: 15710832.
      View in: PubMed
    60. Cheung MC, Nune GC, Hwang DG, Sutter EE, Duncan J. Acute zonal occult outer retinopathy in a patient with graft-versus-host disease. Am J Ophthalmol. 2004 Dec; 138(6):1058-60. PMID: 15629309.
      View in: PubMed
    61. Kuo YM, Duncan J, Westaway SK, Yang H, Nune G, Xu EY, Hayflick SJ, Gitschier J. Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia. Hum Mol Genet. 2005 Jan 01; 14(1):49-57. PMID: 15525657; PMCID: PMC2117329.
      View in: PubMed, PubMed Central
    62. Paskowitz DM, Nune G, Yasumura D, Yang H, Bhisitkul RB, Sharma S, Matthes MT, Zarbin MA, Lavail MM, Duncan J. BDNF reduces the retinal toxicity of verteporfin photodynamic therapy. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):4190-6. PMID: 15505074.
      View in: PubMed
    63. Wilson HL, Schwartz DM, Bhatt HR, McCulloch CE, Duncan J. Statin and aspirin therapy are associated with decreased rates of choroidal neovascularization among patients with age-related macular degeneration. Am J Ophthalmol. 2004 Apr; 137(4):615-24. PMID: 15059698.
      View in: PubMed
    64. Cheung MC, Nune GC, Wang M, McTaggart KE, MacDonald IM, Duncan J. Detection of localized retinal dysfunction in a choroideremia carrier. Am J Ophthalmol. 2004 Jan; 137(1):189-91. PMID: 14700671.
      View in: PubMed
    65. Duncan J, LaVail MM, Yasumura D, Matthes MT, Yang H, Trautmann N, Chappelow AV, Feng W, Earp HS, Matsushima GK, Vollrath D. An RCS-like retinal dystrophy phenotype in mer knockout mice. Invest Ophthalmol Vis Sci. 2003 Feb; 44(2):826-38. PMID: 12556419.
      View in: PubMed
    66. Duncan J, Yang H, Vollrath D, Yasumura D, Matthes MT, Trautmann N, Chappelow AV, Feng W, Earp HS, Matsushima GK, LaVail MM. Inherited retinal dystrophy in Mer knockout mice. Adv Exp Med Biol. 2003; 533:165-72. PMID: 15180261.
      View in: PubMed
    67. Bok D, Yasumura D, Matthes MT, Ruiz A, Duncan J, Chappelow AV, Zolutukhin S, Hauswirth W, LaVail MM. Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation. Exp Eye Res. 2002 Jun; 74(6):719-35. PMID: 12126945.
      View in: PubMed
    68. Duncan J, Aleman TS, Gardner LM, De Castro E, Marks DA, Emmons JM, Bieber ML, Steinberg JD, Bennett J, Stone EM, MacDonald IM, Cideciyan AV, Maguire MG, Jacobson SG. Macular pigment and lutein supplementation in choroideremia. Exp Eye Res. 2002 Mar; 74(3):371-81. PMID: 12014918.
      View in: PubMed
    69. Vollrath D, Feng W, Duncan J, Yasumura D, D'Cruz PM, Chappelow A, Matthes MT, Kay MA, LaVail MM. Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12584-9. PMID: 11592982; PMCID: PMC60097.
      View in: PubMed, PubMed Central
    70. Aleman TS, Duncan J, Bieber ML, de Castro E, Marks DA, Gardner LM, Steinberg JD, Cideciyan AV, Maguire MG, Jacobson SG. Macular pigment and lutein supplementation in retinitis pigmentosa and Usher syndrome. Invest Ophthalmol Vis Sci. 2001 Jul; 42(8):1873-81. PMID: 11431456.
      View in: PubMed
    71. Slaughter JL, Harrington MA, Peroutka SJ. 6-substituted tricyclic partial ergoline compounds are selective and potent 5-hydroxytryptamine1A receptor agents. Life Sci. 1990; 47(15):1331-7. PMID: 2172684.
      View in: PubMed
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