James Bayrer, MD, PhD

Title(s)Assistant Professor, Pediatrics
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Case Western Reserve UniversityM.D.2007School of Medicine
    Case Western Reserve UniversityPh.D.2005Pharmacology
    Collapse Awards and Honors
    NASPGHAN 2015Young Faculty Investigator Research Award
    Kenneth Rainin Foundation Innovations Symposium2015Poster Award
    ACG-CCFA IBD Circle Spotlight2015Best of DDW
    American Gastroenterological Association, DDW2015Poster of Distinction
    American Gastroenterological Association, DDW2014Poster of Distinction
    NASPGHAN 2008Teaching and Tomorrow Travel Award
    Lepow Research Day, CWRU2005Outstanding Poster Presentation Award
    ShowCase, CWRU2004Sigma Xi Award for Poster Presentation
    Graduate Student Symposium, CWRU2003President's Award for Outstanding Poster Presentation
    Claremont McKenna College1998Honors in Chemistry
    Claremont McKenna College1998Honors in Literature
    Claremont McKenna College1998Magna cum Laude
    Joint Science Program, Claremont McKenna College1998Top Thesis in the Sciences

    Collapse Overview 
    Collapse Overview
    As a pediatric gastroenterologist and physician scientist, I am keenly aware of the challenges faced by our pediatric population. The intestinal epithelium comprises the human body’s greatest environmentally exposed surface and is the largest sensory and endocrine organ. My research utilizes human intestinal organoids and animal models to understand how the intestine senses and responds to both regular and inflammatory stimuli. By investigating the molecular pathways involved, we aim to discover new ways to promote intestinal wound healing and modulate the signals contributing to visceral pain syndromes.

    Collapse Research 
    Collapse Research Activities and Funding
    Uncovering the role of LRH-1 in enteroendocrine cell development and ?gut-brain? communication
    NIH/NIDDK R03DK121061Apr 25, 2019 - Mar 31, 2021
    Role: Principal Investigator
    Targeting Intestinal Epithelium to Promote Healing in Inflammatory Bowel Disease
    NIH/NIDDK K08DK106577Jul 18, 2016 - Jun 30, 2019
    Role: Principal Investigator
    Creating a Pediatric Inflammatory Bowel Disease Intestinal Organoid Biorepository for Personalized Therapeutic Discovery
    RAP Pilot Award for Junior Investigators B27552DJul 1, 2016 - Jun 30, 2017
    Role: Principal Investigator
    LRH-1: Structure-based Approach to Drug Design for Gastrointestinal Tumors
    NIH/NCI F32CA163092Apr 1, 2012 - Mar 31, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA. Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones. Nat Commun. 2019 01 11; 10(1):163. PMID: 30635563.
      View in: PubMed
    2. Kulkarni S, Ganz J, Bayrer J, Becker L, Bogunovic M, Rao M. Advances in Enteric Neurobiology: The "Brain" in the Gut in Health and Disease. J Neurosci. 2018 10 31; 38(44):9346-9354. PMID: 30381426.
      View in: PubMed
    3. Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA. LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. Nat Commun. 2018 10 10; 9(1):4055. PMID: 30305617.
      View in: PubMed
    4. Bellono NW, Bayrer JR, Leitch DB, Castro J, Zhang C, O'Donnell TA, Brierley SM, Ingraham HA, Julius D. Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways. Cell. 2017 Jun 29; 170(1):185-198.e16. PMID: 28648659.
      View in: PubMed
    5. Wallach TE, Bayrer JR. Intestinal Organoids: New Frontiers in the Study of Intestinal Disease and Physiology. J Pediatr Gastroenterol Nutr. 2017 02; 64(2):180-185. PMID: 27632431.
      View in: PubMed
    6. Bayrer JR, Mukkamala S, Sablin EP, Webb P, Fletterick RJ. Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2467-72. PMID: 25675535.
      View in: PubMed
    7. Yang Y, Zhang W, Bayrer JR, Weiss MA. Doublesex and the regulation of sexual dimorphism in Drosophila melanogaster: structure, function, and mutagenesis of a female-specific domain. J Biol Chem. 2008 Mar 14; 283(11):7280-92. PMID: 18184648.
      View in: PubMed
    8. Bayrer JR, Zhang W, Weiss MA. Dimerization of doublesex is mediated by a cryptic ubiquitin-associated domain fold: implications for sex-specific gene regulation. J Biol Chem. 2005 Sep 23; 280(38):32989-96. PMID: 16049008.
      View in: PubMed
    9. Bayrer J, Wan Z, Li B, Weiss MA. Expression, crystallization and preliminary X-ray characterization of the Drosophila transcription factor Doublesex. Acta Crystallogr D Biol Crystallogr. 2004 Jul; 60(Pt 7):1328-30. PMID: 15213406.
      View in: PubMed