James Ryan, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1991 Medicine
    University of California, San FranciscoResidency

    Collapse Research 
    Collapse Research Activities and Funding
    HCV resolution correlates with patterned KIR expressions on lymphocytes.
    NIH R01AI083113Jun 15, 2010 - May 31, 2016
    Role: Principal Investigator
    Bay Area Hepatitis C Cooperative Research Center
    NIH U19AI088790Jun 15, 2010 - May 31, 2016
    Role: Co-Investigator
    CONTROL OF ALLOGENIC NK CELL LYSIS BY LECTIN RECEPTORS
    NIH R01AI044126Mar 1, 1999 - Feb 28, 2005
    Role: Principal Investigator
    MOLECULAR ACTIVATION OF NK CELLS THROUGH NKR-P1
    NIH R29CA060944Jul 1, 1993 - Jun 30, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hepatocellular carcinoma after direct-acting antivirals for hepatitis C is associated with KIR-HLA types predicting weak NK cell-mediated immunity. Eur J Immunol. 2024 Aug; 54(8):e2350678. Ryan JC, Haight C, Niemi EC, Grab JD, Dodge JL, Lanier LL, Monto A. PMID: 38700055.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Association of the patterns of use of medications with mortality of COVID-19 infection: a hospital-based observational study. BMJ Open. 2021 12 31; 11(12):e050051. Wallace AW, Cirillo PM, Ryan JC, Krigbaum NY, Badathala A, Cohn BA. PMID: 34972763; PMCID: PMC8720638.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    3. Surgical Site Complications in Open Pronation-Abduction Ankle Fracture-Dislocations With Medial Tension Failure Wounds. J Orthop Trauma. 2021 Dec 01; 35(12):e481-e485. Martin CW, Ryan JC, Bullock TS, Cabot JH, Makhani AA, Griffin LP, Zelle BA. PMID: 33771964.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    4. Fate of the Uninsured Ankle Fracture: Significant Delays in Treatment Result in an Increased Risk of Surgical Site Infection. J Orthop Trauma. 2021 03 01; 35(3):154-159. Zelle BA, Johnson TR, Ryan JC, Martin CW, Cabot JH, Griffin LP, Bullock TS, Ahmad F, Brady CI, Shah K. PMID: 32947353.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    5. Skin closure with surgical staples in ankle fractures: a safe and reliable method. Int Orthop. 2021 01; 45(1):275-280. Prabhakar G, Bullock TS, Martin CW, Ryan JC, Cabot JH, Makhani AA, Griffin LP, Shah K, Zelle BA. PMID: 32951119.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. SHIP1 Deficiency in Inflammatory Bowel Disease Is Associated With Severe Crohn's Disease and Peripheral T Cell Reduction. Front Immunol. 2018; 9:1100. Fernandes S, Srivastava N, Sudan R, Middleton FA, Shergill AK, Ryan JC, Kerr WG. PMID: 29872435; PMCID: PMC5972310.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    7. Identification of MHC Class Ib Ligands for Stimulatory and Inhibitory Ly49 Receptors and Induction of Potent NK Cell Alloresponses in Rats. J Immunol. 2018 04 15; 200(8):2847-2859. Dai KZ, Ryan JC, Naper C, Vaage JT. PMID: 29531166; PMCID: PMC5893382.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    8. Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success. J Immunol. 2018 02 01; 200(3):1124-1132. Méndez-Lagares G, Lu D, Chen C, Terrault N, Segal MR, Khalili M, Monto A, Shen H, Manos MM, Lanier LL, Ryan JC, McCune JM, Hartigan-O'Connor DJ. PMID: 29263212; PMCID: PMC5780234.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    9. NKG2D ligand expression in Crohn's disease and NKG2D-dependent stimulation of CD8+ T cell migration. Exp Mol Pathol. 2017 08; 103(1):56-70. Vadstrup K, Galsgaard ED, Jensen H, Lanier LL, Ryan JC, Chen SY, Nolan GP, Vester-Andersen MK, Pedersen JS, Gerwien J, Jensen T, Bendtsen F. PMID: 28684217; PMCID: PMC5560431.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    10. P-305 SHIP1 Deficiency in Adult Inflammatory Bowel Disease Is Associated with Severe Crohn's Disease and Peripheral T Cell Reduction. Inflammatory Bowel Diseases. 2017 Feb 1; 23(&NA;):s97-s98. Denney DS, Srivastava SN, Middleton MF, Ryan RJ, Kerr KW. .
      View in: Publisher Site   Mentions:
    11. IL-33 promotes growth and liver metastasis of colorectal cancer in mice by remodeling the tumor microenvironment and inducing angiogenesis. Mol Carcinog. 2017 01; 56(1):272-287. Zhang Y, Davis C, Shah S, Hughes D, Ryan JC, Altomare D, Peña MM. PMID: 27120577; PMCID: PMC5630136.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    12. Improved Survival Among all Interferon-α-Treated Patients in HCV-002, a Veterans Affairs Hepatitis C Cohort of 2211 Patients, Despite Increased Cirrhosis Among Nonresponders. Dig Dis Sci. 2016 06; 61(6):1744-56. Cozen ML, Ryan JC, Shen H, Cheung R, Kaplan DE, Pocha C, Brau N, Aytaman A, Schmidt WN, Pedrosa M, Anand BS, Chang KM, Morgan T, Monto A. PMID: 27059981; PMCID: PMC5308124.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. P-177 Altered SHIP1-Protein Degradation in a Subset of IBD Patients. Inflammatory Bowel Diseases. 2016 Mar 1; 22(&NA;):s63. Fernandes FS, Ryan RJ, Middleton MF, Chisholm CJ, Kerr KW. .
      View in: Publisher Site   Mentions:
    14. P-176 SHIP1 Deficiency in Human IBD. Inflammatory Bowel Diseases. 2016 Mar 1; 22(&NA;):s63. Kerr KW, Fernandes FS, Middleton MF, Chisholm CJ, Ryan RJ. .
      View in: Publisher Site   Mentions:
    15. Protective association of colonoscopy against proximal and distal colon cancer and patterns in interval cancer. Gastrointest Endosc. 2015 Sep; 82(3):529-37.e1. Shergill AK, Conners EE, McQuaid KR, Epstein S, Ryan JC, Shah JN, Inadomi J, Somsouk M. PMID: 25936449; PMCID: PMC4540647.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    16. Transcriptomic signatures in whole blood of patients who acquire a chronic inflammatory response syndrome (CIRS) following an exposure to the marine toxin ciguatoxin. BMC Med Genomics. 2015 Apr 02; 8:15. Ryan JC, Wu Q, Shoemaker RC. PMID: 25889530; PMCID: PMC4392619.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    17. Microarray applications to understand the impact of exposure to environmental contaminants in wild dolphins (Tursiops truncatus). Mar Genomics. 2015 Feb; 19:47-57. Mancia A, Abelli L, Kucklick JR, Rowles TK, Wells RS, Balmer BC, Hohn AA, Baatz JE, Ryan JC. PMID: 25479946.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsPHPublic Health
    18. Structural brain abnormalities in patients with inflammatory illness acquired following exposure to water-damaged buildings: a volumetric MRI study using NeuroQuant®. Neurotoxicol Teratol. 2014 Sep-Oct; 45:18-26. Shoemaker RC, House D, Ryan JC. PMID: 24946038.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    19. Machine learning approaches to investigate the impact of PCBs on the transcriptome of the common bottlenose dolphin (Tursiops truncatus). Mar Environ Res. 2014 Sep; 100:57-67. Mancia A, Ryan JC, Van Dolah FM, Kucklick JR, Rowles TK, Wells RS, Rosel PE, Hohn AA, Schwacke LH. PMID: 24695049.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCellsPHPublic Health
    20. Expanded use of aggressive therapies improves survival in early and intermediate hepatocellular carcinoma. HPB (Oxford). 2014 Aug; 16(8):758-67. Ho EY, Cozen ML, Shen H, Lerrigo R, Trimble E, Ryan JC, Corvera CU, Monto A, HOVAS Group (Hepatocellular Carcinoma Treatment Outcome at VA San Francisco). PMID: 24467780; PMCID: PMC4113259.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    21. Monocyte activation by interferon α is associated with failure to achieve a sustained virologic response after treatment for hepatitis C virus infection. J Infect Dis. 2014 May 15; 209(10):1602-12. Hartigan-O'Connor DJ, Lin D, Ryan JC, Shvachko VA, Cozen ML, Segal MR, Terrault NA, Lanier LL, Manos MM, McCune JM. PMID: 24325966; PMCID: PMC3997582.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    22. O-018 SHIP1-deficiency in a Subset of IBD Patients. Inflammatory Bowel Diseases. 2013 Dec 1; 19(&NA;):s13. Fernandes FS, Ryan RJ, Kerr KW. .
      View in: Publisher Site   Mentions:
    23. Transcriptomic responses of juvenile Pacific whiteleg shrimp, Litopenaeus vannamei, to hypoxia and hypercapnic hypoxia. Physiol Genomics. 2013 Sep 03; 45(17):794-807. Rathburn CK, Sharp NJ, Ryan JC, Neely MG, Cook M, Chapman RW, Burnett LE, Burnett KG. PMID: 23821614.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    24. Nonresponse to interferon-α based treatment for chronic hepatitis C infection is associated with increased hazard of cirrhosis. PLoS One. 2013; 8(4):e61568. Cozen ML, Ryan JC, Shen H, Lerrigo R, Yee RM, Sheen E, Wu R, Monto A. PMID: 23637856; PMCID: PMC3636226.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    25. Impaired lymphocyte reactivity measured by immune function testing in untransplanted patients with cirrhosis. Clin Vaccine Immunol. 2013 Apr; 20(4):526-9. Yee RM, Lehil MS, Rongey C, Shen H, Cozen ML, Monto A, Ryan JC. PMID: 23389930; PMCID: PMC3623409.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    26. Health status, infection and disease in California sea lions (Zalophus californianus) studied using a canine microarray platform and machine-learning approaches. Dev Comp Immunol. 2012 Apr; 36(4):629-37. Mancia A, Ryan JC, Chapman RW, Wu Q, Warr GW, Gulland FM, Van Dolah FM. PMID: 22067742.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    27. Transcriptome remodeling associated with chronological aging in the dinoflagellate, Karenia brevis. Mar Genomics. 2012 Mar; 5:15-25. Johnson JG, Morey JS, Neely MG, Ryan JC, Van Dolah FM. PMID: 22325718.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    28. Development of a measure of work motivation for a meta-theory of motivation. Psychol Rep. 2011 Jun; 108(3):743-55. Ryan JC. PMID: 21879620.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. The rat NK cell receptors Ly49s4 and Ly49i4 recognize nonclassical MHC-I molecules on Listeria monocytogenes-infected macrophages. J Leukoc Biol. 2011 Apr; 89(4):617-23. Shegarfi H, Dai KZ, Daws MR, Ryan JC, Vaage JT, Rolstad B, Naper C. PMID: 21248147.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    30. The activating rat Ly49s5 receptor responds to increased levels of MHC class Ib molecules on Listeria monocytogenes-infected enteric epithelial cells. Eur J Immunol. 2010 Dec; 40(12):3535-43. Shegarfi H, Dai KZ, Inngjerdingen M, Ryan JC, Vaage JT, Rolstad B, Naper C. PMID: 21108473.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    31. Effects of COX inhibitors on neurodegeneration and survival in mice exposed to the marine neurotoxin domoic acid. Neurosci Lett. 2011 Jan 03; 487(1):83-7. Ryan JC, Cross CA, Van Dolah FM. PMID: 20934488.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    32. Gene expression profiling in brain of mice exposed to the marine neurotoxin ciguatoxin reveals an acute anti-inflammatory, neuroprotective response. BMC Neurosci. 2010 Aug 26; 11:107. Ryan JC, Morey JS, Bottein MY, Ramsdell JS, Van Dolah FM. PMID: 20796285; PMCID: PMC2939656.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    33. Defining the neurotoxin derived illness chronic ciguatera using markers of chronic systemic inflammatory disturbances: a case/control study. Neurotoxicol Teratol. 2010 Nov-Dec; 32(6):633-9. Shoemaker RC, House D, Ryan JC. PMID: 20685390.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    34. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3505-10. Li L, Fang CJ, Ryan JC, Niemi EC, Lebrón JA, Björkman PJ, Arase H, Torti FM, Torti SV, Nakamura MC, Seaman WE. PMID: 20133674; PMCID: PMC2840523.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansCells
    35. Response. Gastrointestinal Endoscopy. 2009 Nov 1; 70(5):1050-1051. Shergill SA, Asundi AK, Barr BA, Shah SJ, Ryan RJ, McQuaid MK, Rempel RD. .
      View in: Publisher Site   Mentions:
    36. Pinch force and forearm-muscle load during routine colonoscopy: a pilot study. Gastrointest Endosc. 2009 Jan; 69(1):142-6. Shergill AK, Asundi KR, Barr A, Shah JN, Ryan JC, McQuaid KR, Rempel D. PMID: 19111694.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    37. Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis. Hepatology. 2008 Aug; 48(2):670-8. Maher JJ, Leon P, Ryan JC. PMID: 18666225; PMCID: PMC3592568.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansCells
    38. Corrigendum to “A prospective study to examine persistent HCV reinfection in injection drug users who have previously cleared the virus” [Drug Alcohol Depend. 93(1–2) (2008) 148–154]. Drug and Alcohol Dependence. 2008 Jul 1; 96(1-2):192. Currie CS, Ryan RJ, Tracy TD, Wright WT, George GS, McQuaid MR, Kim KM, Shen SH, Monto MA. .
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    39. Endoscopic Evaluation and Management of Colonic Postpolypectomy Hemorrhage. Gastrointestinal Endoscopy. 2008 Apr 1; 67(5):ab320. Chen CJ, Shergill SA, Mcquaid MK, Ryan RJ, Shah SJ. .
      View in: Publisher Site   Mentions:
    40. Liver genomic responses to ciguatoxin: evidence for activation of phase I and phase II detoxification pathways following an acute hypothermic response in mice. Toxicol Sci. 2008 Jun; 103(2):298-310. Morey JS, Ryan JC, Bottein Dechraoui MY, Rezvani AH, Levin ED, Gordon CJ, Ramsdell JS, Van Dolah FM. PMID: 18353800.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    41. Transcriptional profiling and inhibition of cholesterol biosynthesis in human T lymphocyte cells by the marine toxin azaspiracid. Genomics. 2008 Mar; 91(3):289-300. Twiner MJ, Ryan JC, Morey JS, Smith KJ, Hammad SM, Van Dolah FM, Hess P, McMahon T, Satake M, Yasumoto T, Doucette GJ. PMID: 18191373.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    42. A prospective study to examine persistent HCV reinfection in injection drug users who have previously cleared the virus. Drug Alcohol Depend. 2008 Jan 11; 93(1-2):148-54. Currie SL, Ryan JC, Tracy D, Wright TL, George S, McQuaid R, Kim M, Shen H, Monto A. PMID: 17977668.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    43. Transcriptional profiling of whole blood and serum protein analysis of mice exposed to the neurotoxin Pacific Ciguatoxin-1. Neurotoxicology. 2007 Nov; 28(6):1099-109. Ryan JC, Bottein Dechraoui MY, Morey JS, Rezvani A, Levin ED, Gordon CJ, Ramsdell JS, Van Dolah FM. PMID: 17868886.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    44. Prospective Randomized Trial of Standard Versus Magnetic Endoscope Imaging Colonoscopes On Patient Tolerance of Unsedated Colonoscopy. Gastrointestinal Endoscopy. 2007 Apr 1; 65(5):ab253. Shergill SA, Deleon DA, Ryan RJ, Mcquaid MK, Shah SJ. .
      View in: Publisher Site   Mentions:
    45. Evaluation of Distal Upper Extremity Musculoskeletal Load During Routine Colonoscopy. Gastrointestinal Endoscopy. 2007 Apr 1; 65(5):ab315. Shergill SA, Asundi AK, Barr BA, Shah SJ, Ryan RJ, Mcquaid MK, Rempel RD. .
      View in: Publisher Site   Mentions:
    46. Microarray validation: factors influencing correlation between oligonucleotide microarrays and real-time PCR. Biol Proced Online. 2006; 8:175-93. Morey JS, Ryan JC, Van Dolah FM. PMID: 17242735; PMCID: PMC1779618.
      View in: PubMed   Mentions: 259  
    47. Strain-dependent expression of four structurally related rat Ly49 receptors; correlation with NK gene complex haplotype and NK alloreactivity. Immunogenetics. 2006 Nov; 58(11):905-16. Kveberg L, Dai KZ, Dissen E, Ryan JC, Rolstad B, Vaage JT, Naper C. PMID: 17028855.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    48. The novel inhibitory NKR-P1C receptor and Ly49s3 identify two complementary, functionally distinct NK cell subsets in rats. J Immunol. 2006 Apr 01; 176(7):4133-40. Kveberg L, Bäck CJ, Dai KZ, Inngjerdingen M, Rolstad B, Ryan JC, Vaage JT, Naper C. PMID: 16547249.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    49. Acute phase gene expression in mice exposed to the marine neurotoxin domoic acid. Neuroscience. 2005; 136(4):1121-32. Ryan JC, Morey JS, Ramsdell JS, Van Dolah FM. PMID: 16216424.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    50. Gene expression in Florida red tide dinoflagellate Karenia brevis: analysis of an expressed sequence tag library and development of DNA microarray. Mar Biotechnol (NY). 2005 Sep-Oct; 7(5):481-93. Lidie KB, Ryan JC, Barbier M, Van Dolah FM. PMID: 15976935.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    51. Expression of regulator of G protein signalling proteins in natural killer cells, and their modulation by Ly49A and Ly49D. Immunology. 2005 Jul; 115(3):358-65. Kveberg L, Ryan JC, Rolstad B, Inngjerdingen M. PMID: 15946253; PMCID: PMC1782169.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    52. Two structurally related rat Ly49 receptors with opposing functions (Ly49 stimulatory receptor 5 and Ly49 inhibitory receptor 5) recognize nonclassical MHC class Ib-encoded target ligands. J Immunol. 2005 Mar 01; 174(5):2702-11. Naper C, Dai KZ, Kveberg L, Rolstad B, Niemi EC, Vaage JT, Ryan JC. PMID: 15728478.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    53. Molecular cloning of KLRI1 and KLRI2, a novel pair of lectin-like natural killer-cell receptors with opposing signalling motifs. Immunogenetics. 2005 Feb; 56(11):833-9. Saether PC, Westgaard IH, Flornes LM, Hoelsbrekken SE, Ryan JC, Fossum S, Dissen E. PMID: 15650876.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    54. The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex. Eur J Immunol. 2005 Jan; 35(1):261-72. Nylenna O, Naper C, Vaage JT, Woon PY, Gauguier D, Dissen E, Ryan JC, Fossum S. PMID: 15593300.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    55. Killer cell lectin-like receptors and the natural killer cell gene complex. Adv Exp Med Biol. 2005; 564:23-4. Nylenna O, Flornes LM, Westgaard IH, Woon PY, Naper C, Vaage JT, Gauguier D, Ryan JC, Dissen E, Fossum S. PMID: 16400803.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    56. Activating and inhibitory Ly49 receptors modulate NK cell chemotaxis to CXC chemokine ligand (CXCL) 10 and CXCL12. J Immunol. 2003 Sep 15; 171(6):2889-95. Inngjerdingen M, Rolstad B, Ryan JC. PMID: 12960311.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    57. Cutting edge: molecular cloning of a killer cell Ig-like receptor in the mouse and rat. J Immunol. 2003 Mar 01; 170(5):2259-63. Hoelsbrekken SE, Nylenna Ø, Saether PC, Slettedal IO, Ryan JC, Fossum S, Dissen E. PMID: 12594244.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    58. Ly49i2 is an inhibitory rat natural killer cell receptor for an MHC class Ia molecule (RT1-A1c). Eur J Immunol. 2002 Jul; 32(7):2031-6. Naper C, Hayashi S, Joly E, Butcher GW, Rolstad B, Vaage JT, Ryan JC. PMID: 12115624.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    59. Ly-49s3 is a promiscuous activating rat NK cell receptor for nonclassical MHC class I-encoded target ligands. J Immunol. 2002 Jul 01; 169(1):22-30. Naper C, Hayashi S, Kveberg L, Niemi EC, Lanier LL, Vaage JT, Ryan JC. PMID: 12077224.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    60. Characterization of a novel killer cell lectin-like receptor (KLRH1) expressed by alloreactive rat NK cells. J Immunol. 2002 May 15; 168(10):5147-54. Naper C, Hayashi S, Løvik G, Kveberg L, Niemi EC, Rolstad B, Dissen E, Ryan JC, Vaage JT. PMID: 11994469.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    61. A visual pigment expressed in both rod and cone photoreceptors. Neuron. 2001 Nov 08; 32(3):451-61. Ma J, Znoiko S, Othersen KL, Ryan JC, Das J, Isayama T, Kono M, Oprian DD, Corson DW, Cornwall MC, Cameron DA, Harosi FI, Makino CL, Crouch RK. PMID: 11709156.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    62. Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. Eur J Immunol. 2001 Mar; 31(3):783-91. Daws MR, Lanier LL, Seaman WE, Ryan JC. PMID: 11241283.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    63. Expression of the platelet receptor GPVI confers signaling via the Fc receptor gamma -chain in response to the snake venom convulxin but not to collagen. J Biol Chem. 2001 Apr 20; 276(16):12999-3006. Zheng YM, Liu C, Chen H, Locke D, Ryan JC, Kahn ML. PMID: 11152687.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    64. Characterization and molecular cloning of rat C1qRp, a receptor on NK cells. Eur J Immunol. 2000 Dec; 30(12):3355-62. Løvik G, Vaage JT, Dissen E, Szpirer C, Ryan JC, Rolstad B. PMID: 11093152.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    65. Activating Ly-49D and inhibitory Ly-49A natural killer cell receptors demonstrate distinct requirements for interaction with H2-D(d). J Exp Med. 2000 Aug 07; 192(3):447-54. Nakamura MC, Hayashi S, Niemi EC, Ryan JC, Seaman WE. PMID: 10934233; PMCID: PMC2193226.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    66. Molecular characterization of the rat NK cell receptor 2B4. Mol Immunol. 2000 Aug-Sep; 37(12-13):735-44. Kumaresan PR, Stepp SE, Verrett PC, Chuang SS, Boles KS, Lai WC, Ryan JC, Bennett M, Kumar V, Mathew PA. PMID: 11275258.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    67. Functional analysis of natural killer cell receptors in the RNK-16 rat leukemic cell line. Methods Mol Biol. 2000; 121:283-95. Ryan JC, Niemi EC, Nakamura MC. PMID: 10818734.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    68. Natural killing of xenogeneic cells mediated by the mouse Ly-49D receptor. J Immunol. 1999 Nov 01; 163(9):4694-700. Nakamura MC, Naper C, Niemi EC, Spusta SC, Rolstad B, Butcher GW, Seaman WE, Ryan JC. PMID: 10528166.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    69. Inhibitory receptors alter natural killer cell interactions with target cells yet allow simultaneous killing of susceptible targets. J Exp Med. 1999 Oct 04; 190(7):1005-12. Eriksson M, Leitz G, Fällman E, Axner O, Ryan JC, Nakamura MC, Sentman CL. PMID: 10510090; PMCID: PMC2195645.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    70. Ly49A inhibitory receptors redistribute on natural killer cells during target cell interaction. Immunology. 1999 Jun; 97(2):341-7. Eriksson M, Ryan JC, Nakamura MC, Sentman CL. PMID: 10447751; PMCID: PMC2326823.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    71. Genes in two major histocompatibility complex class I regions control selection, phenotype, and function of a rat Ly-49 natural killer cell subset. Eur J Immunol. 1999 06; 29(6):2046-53. Naper C, Ryan JC, Kirsch R, Butcher GW, Rolstad B, Vaage JT. PMID: 10382768.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    72. Mouse Ly-49D recognizes H-2Dd and activates natural killer cell cytotoxicity. J Exp Med. 1999 Feb 01; 189(3):493-500. Nakamura MC, Linnemeyer PA, Niemi EC, Mason LH, Ortaldo JR, Ryan JC, Seaman WE. PMID: 9927511; PMCID: PMC2192910.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    73. Alpha1/alpha2 domains of H-2D(d), but not H-2L(d), induce "missing self" reactivity in vivo--no effect of H-2L(d) on protection against NK cells expressing the inhibitory receptor Ly49G2. Eur J Immunol. 1998 12; 28(12):4198-206. Johansson MH, Höglund E, Nakamura MC, Ryan JC, Höglund P. PMID: 9862356.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    74. Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development. J Exp Med. 1998 Nov 02; 188(9):1651-6. Wakil AE, Wang ZE, Ryan JC, Fowell DJ, Locksley RM. PMID: 9802977; PMCID: PMC2212510.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    75. The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A. J Immunol. 1998 Jun 15; 160(12):5971-8. Sundbäck J, Nakamura MC, Waldenström M, Niemi EC, Seaman WE, Ryan JC, Kärre K. PMID: 9637511.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    76. Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells. J Exp Med. 1998 Apr 06; 187(7):1157-61. Weber JR, Orstavik S, Torgersen KM, Danbolt NC, Berg SF, Ryan JC, Taskén K, Imboden JB, Vaage JT. PMID: 9529333; PMCID: PMC2212210.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    77. Identification of an inhibitory MHC receptor on alloreactive rat natural killer cells. J Immunol. 1998 Jan 01; 160(1):219-24. Naper C, Ryan JC, Nakamura MC, Lambracht D, Rolstad B, Vaage JT. PMID: 9551974.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    78. Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C. J Immunol. 1997 Apr 15; 158(8):3603-9. Houchins JP, Lanier LL, Niemi EC, Phillips JH, Ryan JC. PMID: 9103421.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    79. Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase. J Exp Med. 1997 Feb 17; 185(4):673-84. Nakamura MC, Niemi EC, Fisher MJ, Shultz LD, Seaman WE, Ryan JC. PMID: 9034146; PMCID: PMC2196152.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    80. Divergent functions of lectin-like receptors on NK cells. Immunol Rev. 1997 Feb; 155:79-89. Ryan JC, Seaman WE. PMID: 9059884.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    81. An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes. J Exp Med. 1996 May 01; 183(5):2197-207. Dissen E, Ryan JC, Seaman WE, Fossum S. PMID: 8642329; PMCID: PMC2192580.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    82. NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity. J Exp Med. 1995 May 01; 181(5):1911-5. Ryan JC, Niemi EC, Nakamura MC, Seaman WE. PMID: 7722466; PMCID: PMC2191987.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    83. Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol. 1994 May 15; 152(10):4758-66. Chan AC, van Oers NS, Tran A, Turka L, Law CL, Ryan JC, Clark EA, Weiss A. PMID: 8176201.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    84. Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules. J Immunol. 1992 Sep 01; 149(5):1631-5. Ryan JC, Turck J, Niemi EC, Yokoyama WM, Seaman WE. PMID: 1506685.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    85. cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6. J Immunol. 1991 Nov 01; 147(9):3229-36. Yokoyama WM, Ryan JC, Hunter JJ, Smith HR, Stark M, Seaman WE. PMID: 1680927.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    86. NKR-P1, an activating molecule on rat natural killer cells, stimulates phosphoinositide turnover and a rise in intracellular calcium. J Immunol. 1991 Nov 01; 147(9):3244-50. Ryan JC, Niemi EC, Goldfien RD, Hiserodt JC, Seaman WE. PMID: 1919012.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
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