James Nunez, PhD

Title(s)Assistant Professor, Cellular Molecular Pharmacology
SchoolSchool of Medicine
AddressLocation Required
Phone415-502-8089
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    University of California, BerkeleyPhD06/2016Molecular and Cell Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Programming epigenetic memory with CRISPR-based technologies
    Howard Hughes Medical Institute Hanna H. Gray FellowshipSep 21, 2017 - Sep 20, 2025
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing. Cell. 2021 04 29; 184(9):2503-2519.e17. Nuñez JK, Chen J, Pommier GC, Cogan JZ, Replogle JM, Adriaens C, Ramadoss GN, Shi Q, Hung KL, Samelson AJ, Pogson AN, Kim JYS, Chung A, Leonetti MD, Chang HY, Kampmann M, Bernstein BE, Hovestadt V, Gilbert LA, Weissman JS. PMID: 33838111.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    2. BRD2 inhibition blocks SARS-CoV-2 infection in vitro by reducing transcription of the host cell receptor ACE2. bioRxiv. 2021 Jan 19. Tian R, Samelson AJ, Rezelj VV, Chen M, Ramadoss GN, Guo X, Kain AM, Tran QD, Lim SA, Lui I, Nunez J, Rockwood SJ, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin B, Vignuzzi M, Kampmann M. PMID: 33501440.
      View in: PubMed   Mentions:
    3. Pervasive functional translation of noncanonical human open reading frames. Science. 2020 03 06; 367(6482):1140-1146. Chen J, Brunner AD, Cogan JZ, Nuñez JK, Fields AP, Adamson B, Itzhak DN, Li JY, Mann M, Leonetti MD, Weissman JS. PMID: 32139545.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    4. Inducible and multiplex gene regulation using CRISPR-Cpf1-based transcription factors. Nat Methods. 2017 Dec; 14(12):1163-1166. Tak YE, Kleinstiver BP, Nuñez JK, Hsu JY, Horng JE, Gong J, Weissman JS, Joung JK. PMID: 29083402.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    5. A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response. Cell. 2016 Dec 15; 167(7):1867-1882.e21. Adamson B, Norman TM, Jost M, Cho MY, Nuñez JK, Chen Y, Villalta JE, Gilbert LA, Horlbeck MA, Hein MY, Pak RA, Gray AN, Gross CA, Dixit A, Parnas O, Regev A, Weissman JS. PMID: 27984733.
      View in: PubMed   Mentions: 217     Fields:    Translation:HumansAnimalsCells
    6. CRISPR Immunological Memory Requires a Host Factor for Specificity. Mol Cell. 2016 06 16; 62(6):824-833. Nuñez JK, Bai L, Harrington LB, Hinder TL, Doudna JA, Nuñez JK, Bai L, Harrington LB, Hinder TL, Doudna JA. PMID: 27211867.
      View in: PubMed   Mentions: 57     Fields:    Translation:Cells
    7. Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering. ACS Chem Biol. 2016 Mar 18; 11(3):681-8. Nuñez JK, Harrington LB, Doudna JA, Nuñez JK, Harrington LB, Doudna JA. PMID: 26857072.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    8. Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for Genome Engineering. Cell. 2016 Jan 14; 164(1-2):29-44. Wright AV, Nuñez JK, Doudna JA, Wright AV, Nuñez JK, Doudna JA. PMID: 26771484.
      View in: PubMed   Mentions: 333     Fields:    Translation:HumansAnimalsCells
    9. Foreign DNA capture during CRISPR-Cas adaptive immunity. Nature. 2015 Nov 26; 527(7579):535-8. Nuñez JK, Harrington LB, Kranzusch PJ, Engelman AN, Doudna JA, Nuñez JK, Harrington LB, Kranzusch PJ, Engelman AN, Doudna JA. PMID: 26503043; PMCID: PMC4662619.
      View in: PubMed   Mentions: 72     Fields:    Translation:Cells
    10. Integrase-mediated spacer acquisition during CRISPR-Cas adaptive immunity. Nature. 2015 Mar 12; 519(7542):193-8. Nuñez JK, Lee AS, Engelman A, Doudna JA, Nuñez JK, Lee AS, Engelman A, Doudna JA. PMID: 25707795; PMCID: PMC4359072.
      View in: PubMed   Mentions: 128     Fields:    Translation:Cells
    11. Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity. Nat Struct Mol Biol. 2014 Jun; 21(6):528-34. Nuñez JK, Kranzusch PJ, Noeske J, Wright AV, Davies CW, Doudna JA, Nuñez JK, Kranzusch PJ, Noeske J, Wright AV, Davies CW, Doudna JA. PMID: 24793649; PMCID: PMC4075942.
      View in: PubMed   Mentions: 157     Fields:    Translation:Cells
    12. Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. Nat Struct Mol Biol. 2012 Dec; 19(12):1266-72. Musselman CA, Avvakumov N, Watanabe R, Abraham CG, Lalonde ME, Hong Z, Allen C, Roy S, Nuñez JK, Nickoloff J, Kulesza CA, Yasui A, Côté J, Kutateladze TG, Musselman CA, Avvakumov N, Watanabe R, Abraham CG, Lalonde ME, Hong Z, Allen C, Roy S, Nuñez JK, Nickoloff J, Kulesza CA, Yasui A, Côté J, Kutateladze TG. PMID: 23142980; PMCID: PMC3603146.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
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