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Janine Lupo Palladino, PhD

Title(s)Associate Professor, Radiology
SchoolSchool of Medicine
Phone415-502-0646
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    Collapse Biography 
    Collapse Education and Training
    University of PennslyvaniaBSE2001School of Engineering and Applied Sciences
    University of California, Berkeley & San FranciscoPhD2006Joint Graduate Program in Bioegineering
    Collapse Awards and Honors
    ISMRM MR Cancer Study Group2019Secretary
    UCSF2017Johnson & Johnson Women In STEM2D award in Engineering, UCSF nominee
    UCSF2016RAP Family Support Award
    National Institutes of Health 2012Clinical Loan Repayment Program Continuation Award
    UCSF2012RAP Grants Novel Clinical/Translational Methods Award
    UCSF2011Radiology Symposium Poster Award
    UCSF BTS Symposium2010Honorable Mention Poster Award
    National Institutes of Health 2010Clinical Loan Repayment Program Award
    UCSF2010Brain Tumor SPORE Career Development Award
    ISMRM Conference 2010Neuroimaging Poster Award Nomination
    UCSF2008Radiology Symposium Poster Award
    UCSF Department of Radiology and Biomedical Imaging2006Surbeck Scholar Award

    Collapse Overview 
    Collapse Overview
    Janine Lupo, PhD, is an Associate Professor in the Surbeck Laboratory of Advanced Imaging and Neuroimaging Research Interest Group of the Department of Radiology and Biomedical Imaging. She is a member of the UCSF/UC Berkeley Graduate Group in Bioengineering, Helen Diller Family Comprehensive Cancer Center, Institute for Computational Health Sciences, and Quantitative Biosciences Institute. Dr. Lupo received her BSE in Bioengineering at the University of Pennsylvania, School of Engineering and Applied Science in Philadelphia before completing her PhD at the UCSF/UCB PhD Joint Graduate Group in Bioengineering. Before accepting the Assistant Professor position, Dr. Lupo was an Assistant and Associate Researcher in the Department of Radiology and Biomedical Imaging at UCSF.

    Dr. Lupo’s research focuses on the development and application of novel MR imaging data acquisition, processing, and analysis techniques for the evaluation of patients with brain tumors and other neurological diseases using our research 3T and 7T whole body scanners. This includes the development of quantitative algorithms critical for processing data from advanced acquisitions for patient studies, implementation of statistical and machine learning models to relate imaging markers with biological characteristics from pathology and clinical outcome in order to both identify patients who would benefit most for a given therapy, and monitor the effects of therapy over time on tumor control, normal brain tissue structure, and cognition.

    Dr. Lupo is the Principal or Co-Principal Investigator for 3 NIH grants, as well as a co-Project leader of 2 projects within an NIH Programmatic Project Grant and Brain Tumor SPORE Grant. She has published over 50 research articles.

    Expertise:
    Bioengineering

    Specialty:
    Neuroimaging

    Professional Interests:
    Magnetic resonance imaging, ultra-high field MRI, algorithm development for quantitative image analysis, imaging biomarker discovery, brain cancer, neurological diseases, evaluation of therapy, the effects of therapy on cognition, statistical modeling and deep learning

    Collapse Research 
    Collapse Research Activities and Funding
    3D Multi-Contrast MRI with Automatic Brain Tissue and Lesion Segmentation
    NIH/NCI R21CA238137Dec 1, 2019 - Nov 30, 2021
    Role: Co-PI
    Mitigation of preanalytic factors influencing brain tumor protein phosphorylation
    NIH/NCI U01CA229345Apr 1, 2019 - Mar 31, 2024
    Role: Co-Investigator
    IMPROVED MONITORING OF PREMANIFEST AND EARLY HUNTINGTONS USING 7T MULTIMODAL MRI
    NIH/NINDS R01NS099564Jul 1, 2017 - Jun 30, 2022
    Role: Co-PI
    MICROBLEEDS AS A MARKER OF RADIATION-INDUCED BRAIN INJURY IN PEDIATRIC PATIENTS
    NIH R01HD079568Apr 1, 2015 - Jan 31, 2020
    Role: PI
    Brain Vascular Malformation Consortium: Predictor's of Clinical Course
    NIH/NINDS U54NS065705Sep 30, 2009 - Jun 30, 2024
    Role: Co-Investigator
    Imaging and Tissue Correlates to Optimize Management of Glioblastoma
    NIH/NCI P01CA118816Aug 1, 2009 - Jun 30, 2013
    Role: Project Leader, Project 1
    Brain Tumor SPORE Grant
    NIH 2P50CA097257-16Sep 20, 2002 - Aug 31, 2023
    Role: Co-PI of Project 2

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Chen Y, Jakary A, Avadiappan S, Hess CP, Lupo JM. QSMGAN: Improved Quantitative Susceptibility Mapping using 3D Generative Adversarial Networks with increased receptive field. Neuroimage. 2020 Feb 15; 207:116389. PMID: 31760151.
      View in: PubMed
    2. Alcaide-Leon P, Luks TL, Lafontaine M, Lupo JM, Okada H, Clarke JL, Villanueva-Meyer JE. Treatment-induced lesions in newly diagnosed glioblastoma patients undergoing chemoradiotherapy and heat-shock protein vaccine therapy. J Neurooncol. 2020 Jan; 146(1):71-78. PMID: 31728884.
      View in: PubMed
    3. Chen Y, Villanueva-Meyer JE, Morrison MA, Lupo JM. Toward Automatic Detection of Radiation-Induced Cerebral Microbleeds Using a 3D Deep Residual Network. J Digit Imaging. 2019 Oct; 32(5):766-772. PMID: 30511280.
      View in: PubMed
    4. Cao P, Liu J, Tang S, Leynes AP, Lupo JM, Xu D, Larson PEZ. Technical Note: Simultaneous segmentation and relaxometry for MRI through multitask learning. Med Phys. 2019 Oct; 46(10):4610-4621. PMID: 31396973.
      View in: PubMed
    5. Park I, Lupo JM, Nelson SJ. Correlation of Tumor Perfusion Between Carbon-13 Imaging with Hyperpolarized Pyruvate and Dynamic Susceptibility Contrast MRI in Pre-Clinical Model of Glioblastoma. Mol Imaging Biol. 2019 08; 21(4):626-632. PMID: 30225760.
      View in: PubMed
    6. Majumdar S, Lupo J, Vigneron D, Ronen S, Kurhanewicz J, Hess C. In memoriam: Sarah J. Nelson, January 26, 1954-April 3, 2019. Magn Reson Med. 2019 10; 82(4):1255-1258. PMID: 31102294.
      View in: PubMed
    7. Morrison MA, Hess CP, Clarke JL, Butowski N, Chang SM, Molinaro AM, Lupo JM. Risk factors of radiotherapy-induced cerebral microbleeds and serial analysis of their size compared with white matter changes: A 7T MRI study in 113 adult patients with brain tumors. J Magn Reson Imaging. 2019 Sep; 50(3):868-877. PMID: 30663150.
      View in: PubMed
    8. Villanueva-Meyer JE, Chang P, Lupo JM, Hess CP, Flanders AE, Kohli M. Machine Learning in Neurooncology Imaging: From Study Request to Diagnosis and Treatment. AJR Am J Roentgenol. 2019 01; 212(1):52-56. PMID: 30403523.
      View in: PubMed
    9. Vareth M, Lupo J, Larson P, Nelson S. A comparison of coil combination strategies in 3D multi-channel MRSI reconstruction for patients with brain tumors. NMR Biomed. 2018 11; 31(11):e3929. PMID: 30168205.
      View in: PubMed
    10. Morrison MA, Payabvash S, Chen Y, Avadiappan S, Shah M, Zou X, Hess CP, Lupo JM. A user-guided tool for semi-automated cerebral microbleed detection and volume segmentation: Evaluating vascular injury and data labelling for machine learning. Neuroimage Clin. 2018; 20:498-505. PMID: 30140608.
      View in: PubMed
    11. Autry A, Phillips JJ, Maleschlijski S, Roy R, Molinaro AM, Chang SM, Cha S, Lupo JM, Nelson SJ. Characterization of Metabolic, Diffusion, and Perfusion Properties in GBM: Contrast-Enhancing versus Non-Enhancing Tumor. Transl Oncol. 2017 Dec; 10(6):895-903. PMID: 28942218.
      View in: PubMed
    12. Wahl M, Anwar M, Hess CP, Chang SM, Lupo JM. Relationship between radiation dose and microbleed formation in patients with malignant glioma. Radiat Oncol. 2017 Aug 10; 12(1):126. PMID: 28797254.
      View in: PubMed
    13. Wahl M, Chang SM, Phillips JJ, Molinaro AM, Costello JF, Mazor T, Alexandrescu S, Lupo JM, Nelson SJ, Berger M, Prados M, Taylor JW, Butowski N, Clarke JL, Haas-Kogan D. Probing the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in gliomas: A phase 2 study of everolimus for recurrent adult low-grade gliomas. Cancer. 2017 Dec 01; 123(23):4631-4639. PMID: 28759109.
      View in: PubMed
    14. Anwar M, Molinaro AM, Morin O, Chang SM, Haas-Kogan DA, Nelson SJ, Lupo JM. Identifying Voxels at Risk for Progression in Glioblastoma Based on Dosimetry, Physiologic and Metabolic MRI. Radiat Res. 2017 09; 188(3):303-313. PMID: 28723274.
      View in: PubMed
    15. Zou X, Hart BL, Mabray M, Bartlett MR, Bian W, Nelson J, Morrison LA, McCulloch CE, Hess CP, Lupo JM, Kim H. Automated algorithm for counting microbleeds in patients with familial cerebral cavernous malformations. Neuroradiology. 2017 Jul; 59(7):685-690. PMID: 28534135.
      View in: PubMed
    16. Roddy E, Sear K, Felton E, Tamrazi B, Gauvain K, Torkildson J, Buono BD, Samuel D, Haas-Kogan DA, Chen J, Goldsby RE, Banerjee A, Lupo JM, Molinaro AM, Fullerton HJ, Mueller S. Presence of cerebral microbleeds is associated with worse executive function in pediatric brain tumor survivors. Neuro Oncol. 2016 11; 18(11):1548-1558. PMID: 27540084.
      View in: PubMed
    17. Nelson SJ, Li Y, Lupo JM, Olson M, Crane JC, Molinaro A, Roy R, Clarke J, Butowski N, Prados M, Cha S, Chang SM. Serial analysis of 3D H-1 MRSI for patients with newly diagnosed GBM treated with combination therapy that includes bevacizumab. J Neurooncol. 2016 10; 130(1):171-179. PMID: 27535746.
      View in: PubMed
    18. Jalbert LE, Neill E, Phillips JJ, Lupo JM, Olson MP, Molinaro AM, Berger MS, Chang SM, Nelson SJ. Magnetic resonance analysis of malignant transformation in recurrent glioma. Neuro Oncol. 2016 08; 18(8):1169-79. PMID: 26911151.
      View in: PubMed
    19. Park I, von Morze C, Lupo JM, Ardenkjaer-Larsen JH, Kadambi A, Vigneron DB, Nelson SJ. Investigating tumor perfusion by hyperpolarized 13 C MRI with comparison to conventional gadolinium contrast-enhanced MRI and pathology in orthotopic human GBM xenografts. Magn Reson Med. 2017 02; 77(2):841-847. PMID: 26892398.
      View in: PubMed
    20. Wen Q, Jalilian L, Lupo JM, Li Y, Roy R, Molinaro AM, Chang SM, Prados M, Butowski N, Clarke J, Nelson SJ. Association of Diffusion and Anatomic Imaging Parameters with Survival for Patients with Newly Diagnosed Glioblastoma Participating in Two Different Clinical Trials. Transl Oncol. 2015 Dec; 8(6):446-55. PMID: 26692525.
      View in: PubMed
    21. Chaumeil MM, Lupo JM, Ronen SM. Magnetic Resonance (MR) Metabolic Imaging in Glioma. Brain Pathol. 2015 Nov; 25(6):769-80. PMID: 26526945.
      View in: PubMed
    22. Wen Q, Kelley DA, Banerjee S, Lupo JM, Chang SM, Xu D, Hess CP, Nelson SJ. Clinically feasible NODDI characterization of glioma using multiband EPI at 7 T. Neuroimage Clin. 2015; 9:291-9. PMID: 26509116.
      View in: PubMed
    23. Lupo JM, Molinaro AM, Essock-Burns E, Butowski N, Chang SM, Cha S, Nelson SJ. The effects of anti-angiogenic therapy on the formation of radiation-induced microbleeds in normal brain tissue of patients with glioma. Neuro Oncol. 2016 Jan; 18(1):87-95. PMID: 26206774.
      View in: PubMed
    24. Bian W, Banerjee S, Kelly DA, Hess CP, Larson PE, Chang SM, Nelson SJ, Lupo JM. Simultaneous imaging of radiation-induced cerebral microbleeds, arteries and veins, using a multiple gradient echo sequence at 7 Tesla. J Magn Reson Imaging. 2015 Aug; 42(2):269-79. PMID: 25471321.
      View in: PubMed
    25. Wen Q, Jalilian L, Lupo JM, Molinaro AM, Chang SM, Clarke J, Prados M, Nelson SJ. Comparison of ADC metrics and their association with outcome for patients with newly diagnosed glioblastoma being treated with radiation therapy, temozolomide, erlotinib and bevacizumab. J Neurooncol. 2015 Jan; 121(2):331-9. PMID: 25351579.
      View in: PubMed
    26. Lupo JM, Nelson SJ. Advanced magnetic resonance imaging methods for planning and monitoring radiation therapy in patients with high-grade glioma. Semin Radiat Oncol. 2014 Oct; 24(4):248-58. PMID: 25219809.
      View in: PubMed
    27. Li Y, Larson P, Chen AP, Lupo JM, Ozhinsky E, Kelley D, Chang SM, Nelson SJ. Short-echo three-dimensional H-1 MR spectroscopic imaging of patients with glioma at 7 Tesla for characterization of differences in metabolite levels. J Magn Reson Imaging. 2015 May; 41(5):1332-41. PMID: 24935758.
      View in: PubMed
    28. Chaumeil MM, Larson PE, Woods SM, Cai L, Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma. Cancer Res. 2014 Aug 15; 74(16):4247-57. PMID: 24876103.
      View in: PubMed
    29. Apple AC, Possin KL, Satris G, Johnson E, Lupo JM, Jakary A, Wong K, Kelley DA, Kang GA, Sha SJ, Kramer JH, Geschwind MD, Nelson SJ, Hess CP. Quantitative 7T phase imaging in premanifest Huntington disease. AJNR Am J Neuroradiol. 2014 Sep; 35(9):1707-13. PMID: 24742810.
      View in: PubMed
    30. Bian W, Hess CP, Chang SM, Nelson SJ, Lupo JM. Susceptibility-weighted MR imaging of radiation therapy-induced cerebral microbleeds in patients with glioma: a comparison between 3T and 7T. Neuroradiology. 2014 Feb; 56(2):91-6. PMID: 24281386.
      View in: PubMed
    31. Bian W, Hess CP, Chang SM, Nelson SJ, Lupo JM. Computer-aided detection of radiation-induced cerebral microbleeds on susceptibility-weighted MR images. Neuroimage Clin. 2013; 2:282-90. PMID: 24179783.
      View in: PubMed
    32. Li Y, Lupo JM, Parvataneni R, Lamborn KR, Cha S, Chang SM, Nelson SJ. Survival analysis in patients with newly diagnosed glioblastoma using pre- and postradiotherapy MR spectroscopic imaging. Neuro Oncol. 2013 May; 15(5):607-17. PMID: 23393206.
      View in: PubMed
    33. Lupo JM, Essock-Burns E, Molinaro AM, Cha S, Chang SM, Butowski N, Nelson SJ. Using susceptibility-weighted imaging to determine response to combined anti-angiogenic, cytotoxic, and radiation therapy in patients with glioblastoma multiforme. Neuro Oncol. 2013 Apr; 15(4):480-9. PMID: 23393208.
      View in: PubMed
    34. Essock-Burns E, Phillips JJ, Molinaro AM, Lupo JM, Cha S, Chang SM, Nelson SJ. Comparison of DSC-MRI post-processing techniques in predicting microvascular histopathology in patients newly diagnosed with GBM. J Magn Reson Imaging. 2013 Aug; 38(2):388-400. PMID: 23281184.
      View in: PubMed
    35. Bian W, Harter K, Hammond-Rosenbluth KE, Lupo JM, Xu D, Kelley DA, Vigneron DB, Nelson SJ, Pelletier D. A serial in vivo 7T magnetic resonance phase imaging study of white matter lesions in multiple sclerosis. Mult Scler. 2013 Jan; 19(1):69-75. PMID: 22641301.
      View in: PubMed
    36. Li Y, Xu D, Ozturk-Isik E, Lupo JM, Chen AP, Vigneron DB, Nelson SJ.T1 and T2 Metabolite Relaxation Times in Normal Brain at 3T and 7T. J Mol Imaging Dynam. 2012; S1:002.
      View Publication
    37. Lupo JM, Li Y, Hess CP, Nelson SJ. Advances in ultra-high field MRI for the clinical management of patients with brain tumors. Curr Opin Neurol. 2011 Dec; 24(6):605-15. PMID: 22045220.
      View in: PubMed
    38. Lupo JM, Chuang CF, Chang SM, Barani IJ, Jimenez B, Hess CP, Nelson SJ. 7-Tesla susceptibility-weighted imaging to assess the effects of radiotherapy on normal-appearing brain in patients with glioma. Int J Radiat Oncol Biol Phys. 2012 Mar 01; 82(3):e493-500. PMID: 22000750.
      View in: PubMed
    39. Li Y, Lupo JM, Polley MY, Crane JC, Bian W, Cha S, Chang S, Nelson SJ. Serial analysis of imaging parameters in patients with newly diagnosed glioblastoma multiforme. Neuro Oncol. 2011 May; 13(5):546-57. PMID: 21297128.
      View in: PubMed
    40. Essock-Burns E, Lupo JM, Cha S, Polley MY, Butowski NA, Chang SM, Nelson SJ. Assessment of perfusion MRI-derived parameters in evaluating and predicting response to antiangiogenic therapy in patients with newly diagnosed glioblastoma. Neuro Oncol. 2011 Jan; 13(1):119-31. PMID: 21036812.
      View in: PubMed
    41. Tropp J, Lupo JM, Chen A, Calderon P, McCune D, Grafendorfer T, Ozturk-Isik E, Larson PE, Hu S, Yen YF, Robb F, Bok R, Schulte R, Xu D, Hurd R, Vigneron D, Nelson S. Multi-channel metabolic imaging, with SENSE reconstruction, of hyperpolarized [1-(13)C] pyruvate in a live rat at 3.0 tesla on a clinical MR scanner. J Magn Reson. 2011 Jan; 208(1):171-7. PMID: 21130012.
      View in: PubMed
    42. Bian W, Khayal IS, Lupo JM, McGue C, Vandenberg S, Lamborn KR, Chang SM, Cha S, Nelson SJ. Multiparametric characterization of grade 2 glioma subtypes using magnetic resonance spectroscopic, perfusion, and diffusion imaging. Transl Oncol. 2009 Dec; 2(4):271-80. PMID: 19956389.
      View in: PubMed
    43. Lupo JM, Chen AP, Zierhut ML, Bok RA, Cunningham CH, Kurhanewicz J, Vigneron DB, Nelson SJ. Analysis of hyperpolarized dynamic 13C lactate imaging in a transgenic mouse model of prostate cancer. Magn Reson Imaging. 2010 Feb; 28(2):153-62. PMID: 19695815.
      View in: PubMed
    44. Lupo JM, Banerjee S, Hammond KE, Kelley DA, Xu D, Chang SM, Vigneron DB, Majumdar S, Nelson SJ. GRAPPA-based susceptibility-weighted imaging of normal volunteers and patients with brain tumor at 7 T. Magn Reson Imaging. 2009 May; 27(4):480-8. PMID: 18823730.
      View in: PubMed
    45. Cunningham CH, Chen AP, Lustig M, Hargreaves BA, Lupo J, Xu D, Kurhanewicz J, Hurd RE, Pauly JM, Nelson SJ, Vigneron DB. Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products. J Magn Reson. 2008 Jul; 193(1):139-46. PMID: 18424203.
      View in: PubMed
    46. Hammond KE, Lupo JM, Xu D, Metcalf M, Kelley DA, Pelletier D, Chang SM, Mukherjee P, Vigneron DB, Nelson SJ. Development of a robust method for generating 7.0 T multichannel phase images of the brain with application to normal volunteers and patients with neurological diseases. Neuroimage. 2008 Feb 15; 39(4):1682-92. PMID: 18096412.
      View in: PubMed
    47. Lupo JM, Cha S, Chang SM, Nelson SJ. Analysis of metabolic indices in regions of abnormal perfusion in patients with high-grade glioma. AJNR Am J Neuroradiol. 2007 Sep; 28(8):1455-61. PMID: 17846190.
      View in: PubMed
    48. Cha S, Lupo JM, Chen MH, Lamborn KR, McDermott MW, Berger MS, Nelson SJ, Dillon WP. Differentiation of glioblastoma multiforme and single brain metastasis by peak height and percentage of signal intensity recovery derived from dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. AJNR Am J Neuroradiol. 2007 Jun-Jul; 28(6):1078-84. PMID: 17569962.
      View in: PubMed
    49. Lupo JM, Lee MC, Han ET, Cha S, Chang SM, Berger MS, Nelson SJ. Feasibility of dynamic susceptibility contrast perfusion MR imaging at 3T using a standard quadrature head coil and eight-channel phased-array coil with and without SENSE reconstruction. J Magn Reson Imaging. 2006 Sep; 24(3):520-9. PMID: 16888776.
      View in: PubMed
    50. Lupo JM, Banerjee S, Kelley D, Xu D, Vigneron DB, Majumdar S, Nelson SJ. Partially-parallel, susceptibility-weighted MR imaging of brain vasculature at 7 Tesla using sensitivity encoding and an autocalibrating parallel technique. Conf Proc IEEE Eng Med Biol Soc. 2006; 2006:747-50. PMID: 17945996.
      View in: PubMed
    51. Lupo JM, Cha S, Chang SM, Nelson SJ. Dynamic susceptibility-weighted perfusion imaging of high-grade gliomas: characterization of spatial heterogeneity. AJNR Am J Neuroradiol. 2005 Jun-Jul; 26(6):1446-54. PMID: 15956514.
      View in: PubMed
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