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Jason Cyster, PhD

Title(s)Howard Hughes Investigator, Microbiology and Immunology
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE
San Francisco CA 94143
Phone415-502-6427
ORCID ORCID Icon0000-0002-4735-9745 Additional info
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    Other Positions
    Title(s)Howard Hughes Investigator


    Collapse Biography 
    Collapse Education and Training
    University of Western AustraliaB.Sc. (Hons)1988Biochemistry & Microbiology
    University of Oxford, EnglandD. Phil.1992Sir William Dunn School of Pathology
    Stanford Univ. Med Center, Stanford, CAPD Fellow1995
    Collapse Awards and Honors
    1996  - 2000Pew Scholar in the Biomedical Sciences
    1998  - 2003David and Lucile Packard Foundation Fellow
    2002NIH MERIT Award
    2005AAI BD Biosciences Investigator Award
    2010Cancer Research Institute Fredrick W. Alt Award
    2011American Association for the Advancement of Science Fellow
    2014Member of the National Academy of Sciences

    Collapse Overview 
    Collapse Overview
    Cell Migration and Interaction Dynamics Underlying Innate and Adaptive Immunity

    Background: The rapid production of antibodies is critical for host defense against pathogens. Reciprocally, antibody responses against self-components are a cause of autoimmune disease. To mount antibody responses, antigen-specific B and T cells that may be as rare as 1 in 100,000 cells must first encounter the antigen and then interact with each other. These encounters occur within lymphoid organs - lymph nodes, spleen, and mucosal lymphoid tissues - but the mechanisms that control immune cell migration and that promote interactions between rare antigen-specific cells are far from understood. Similar challenges exist in understanding the cell migration and interaction dynamics needed for immune defenses at barrier surfaces.

    Major goals: (i) decipher the guidance cue code controlling leukocyte migration and interactions during immune responses; (ii) characterize selection events required for induction of high affinity antibodies; (iii) define the dynamics of antigen encounter and immune responses at epithelial surfaces.

    On-going Research:

    Chemokines and lipid mediators as lymphoid tissue organizers: Chemokines are small secreted chemoattractive proteins that signal via heterotrimeric G-protein coupled receptors (GPCRs). We have demonstrated that several chemokines are expressed in lymphoid organs and function in guiding lymphocyte migration. We have also identified roles for lipid mediators, including an oxysterol, in guiding cell movements necessary for mounting dendritic cell- and T cell-dependent B cell responses. Transgenic and gene knockout experiments in mice are further defining the organizing functions of these guidance factors. Efforts are ongoing using RNAseq, CRISPR/Cas9 knockdown and retroviral over-expression approaches to test the role of novel guidance factors in promoting cell interactions during innate and adaptive immune responses. Based on our work so far, groups in industry are developing small molecule inhibitors of lymphoid chemoattractant receptors to be tested as modulators of the immune response.

    Lymphocyte Egress and the role of S1P: A lot is known about how cells get into tissues from blood, but much less is understood about how they get out. Yet they must get out to mediate their effector function at sites of infection or autoimmune inflammation. In work over the last 10 years we established that the circulatory lipid, sphingosine-1-phosphate (S1P), is critical for this process. Like chemokines, S1P signals via GPCRs, and we found that if lymphocytes lack one of the five S1P receptors, S1PR1, they are unable to leave the thymus or peripheral lymphoid organs. The compound FTY720 disrupts the function of this receptor and inhibits lymphocyte egress. FTY720 (Fingolimod) was FDA approved in 2010 as a treatment for multiple sclerosis. On-going studies, involving molecular, genetic and imaging approaches, are aimed at defining how this GPCR instructs lymphocytes to exit lymphoid organs. Findings from this work are likely to point to new therapeutic targets for inhibition of unwanted immune responses.

    Affinity Maturation and the Germinal Center response: Although first identified in the 1800's, the inner workings of the germinal center - the site of antibody affinity maturation - are still poorly defined. We have found a role for chemokines in organizing the structure into light and dark zones. Using 2-photon microscopy and real-time imaging of intact lymph nodes we have begun to characterize B and T cell migration and interaction dynamics during the selection events associated with this tightly regulated response. In ongoing work we combine perturbations in organizing molecules with methods to measure affinity maturation and 2-photon microscopy-based imaging approaches to further define how selection of high affinity clones - and elimination of low affinity and autoreactive clones - occurs. This work has direct implications for methods to improve vaccine design.

    Barrier Immunity: IgA is a major antibody isotype made at mucosal surfaces and it functions to shape the commensal populations and to protect from gut pathogens. We are studying how B cells encounter and mount responses against mucosal antigens. We are also interested in understanding how chronic mucosal antigen exposure drives sustained germinal center responses and sometimes leads to lymphomagenesis. As well as IgA, the intestine and skin contain large numbers of innate-like lymphocytes that help maintain tissue homeostasis and barrier immunity. In ongoing work, we are studying the migration and response dynamics of innate-like lymphocytes at epithelial surfaces.

    Collapse Research 
    Collapse Research Activities and Funding
    Cellular and Genetic Analysis of Lymphocyte Egress
    NIH/NIAID R01AI074847Jun 1, 2007 - May 31, 2017
    Role: Principal Investigator
    Chemokines and Lymphoid Tissue Organization and Function
    NIH/NIAID R01AI045073Apr 1, 1999 - Mar 31, 2014
    Role: Principal Investigator
    B lymphocyte Migration and Homeostasis
    NIH/NIAID R01AI040098Apr 1, 1997 - Mar 31, 2022
    Role: Principal Investigator
    Beta Lymphocyte Migration and Homeostasis
    NIH/NIAID R37AI040098Apr 1, 1997 - Mar 31, 2012
    Role: Principal Investigator
    Predoctoral Training in Biomedical Sciences
    NIH/NIGMS T32GM008568Jul 1, 1995 - Mar 31, 2005
    Role: Co-Principal Investigator
    Molecular and Cellular Immunology
    NIH/NIAID T32AI007334Sep 1, 1988 - May 31, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Requirements for cDC2 positioning in blood-exposed regions of the neonatal and adult spleen. J Exp Med. 2020 Nov 02; 217(11). Liu D, Wu J, An J, Cyster JG. PMID: 32808016.
      View in: PubMed   Mentions:    Fields:    
    2. Evaluation of SARS-CoV-2 serology assays reveals a range of test performance. Nat Biotechnol. 2020 Aug 27. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk RP, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. PMID: 32855547.
      View in: PubMed   Mentions:    Fields:    
    3. The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development. Nat Immunol. 2020 Sep; 21(9):1082-1093. Laidlaw BJ, Duan L, Xu Y, Vazquez SE, Cyster JG. PMID: 32601467.
      View in: PubMed   Mentions:    Fields:    
    4. Marginal zone SIGN-R1+ macrophages are essential for the maturation of germinal center B cells in the spleen. Proc Natl Acad Sci U S A. 2020 Jun 02; 117(22):12295-12305. Pirgova G, Chauveau A, MacLean AJ, Cyster JG, Arnon TI. PMID: 32424104.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Test performance evaluation of SARS-CoV-2 serological assays. medRxiv. 2020 May 17. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk R, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. PMID: 32511497.
      View in: PubMed   Mentions:
    6. T follicular helper cells in germinal center B cell selection and lymphomagenesis. Immunol Rev. 2020 Jul; 296(1):48-61. Mintz MA, Cyster JG. PMID: 32412663.
      View in: PubMed   Mentions: 1     Fields:    
    7. GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein. J Clin Invest. 2020 Feb 03; 130(2):1036-1051. Cheng J, Klei LR, Hubel NE, Zhang M, Schairer R, Maurer LM, Klei HB, Kang H, Concel VJ, Delekta PC, Dang EV, Mintz MA, Baens M, Cyster JG, Parameswaran N, Thome M, Lucas PC, McAllister-Lucas LM. PMID: 31961340.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis. Immunity. 2019 08 20; 51(2):310-323.e7. Mintz MA, Felce JH, Chou MY, Mayya V, Xu Y, Shui JW, An J, Li Z, Marson A, Okada T, Ware CF, Kronenberg M, Dustin ML, Cyster JG. PMID: 31204070.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. Sphingosine-1-phosphate receptor 2 restrains egress of ?d T cells from the skin. J Exp Med. 2019 07 01; 216(7):1487-1496. Laidlaw BJ, Gray EE, Zhang Y, Ramírez-Valle F, Cyster JG. PMID: 31160320.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    10. G-protein coupled receptors and ligands that organize humoral immune responses. Immunol Rev. 2019 05; 289(1):158-172. Lu E, Cyster JG. PMID: 30977196.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. B Cell Responses: Cell Interaction Dynamics and Decisions. Cell. 2019 04 18; 177(3):524-540. Cyster JG, Allen CDC. PMID: 31002794.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    12. S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8. Nature. 2019 03; 567(7747):244-248. Lu E, Wolfreys FD, Muppidi JR, Xu Y, Cyster JG. PMID: 30842656.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    13. Loss of sterol metabolic homeostasis triggers inflammasomes?-?how and why. Curr Opin Immunol. 2019 02; 56:1-9. Dang EV, Cyster JG. PMID: 30172069.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    14. Critical role of integrin CD11c in splenic dendritic cell capture of missing-self CD47 cells to induce adaptive immunity. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):6786-6791. Wu J, Wu H, An J, Ballantyne CM, Cyster JG. PMID: 29891680.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity. Immunity. 2018 05 15; 48(5):1014-1028.e6. Rodda LB, Lu E, Bennett ML, Sokol CL, Wang X, Luther SA, Barres BA, Luster AD, Ye CJ, Cyster JG. PMID: 29752062.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    16. G-Protein Coupled Receptor 18 Contributes to Establishment of the CD8 Effector T Cell Compartment. Front Immunol. 2018; 9:660. Sumida H, Cyster JG. PMID: 29670628.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    17. Lysophosphatidylserine suppression of T-cell activation via GPR174 requires Gas proteins. Immunol Cell Biol. 2018 04; 96(4):439-445. Barnes MJ, Cyster JG. PMID: 29457279.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    18. Atypical chemokine receptor 4 shapes activated B cell fate. J Exp Med. 2018 03 05; 215(3):801-813. Kara EE, Bastow CR, McKenzie DR, Gregor CE, Fenix KA, Babb R, Norton TS, Zotos D, Rodda LB, Hermes JR, Bourne K, Gilchrist DS, Nibbs RJ, Alsharifi M, Vinuesa CG, Tarlinton DM, Brink R, Hill GR, Cyster JG, Comerford I, McColl SR. PMID: 29386231.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    19. GPR55 regulates intraepithelial lymphocyte migration dynamics and susceptibility to intestinal damage. Sci Immunol. 2017 12 08; 2(18). Sumida H, Lu E, Chen H, Yang Q, Mackie K, Cyster JG. PMID: 29222090.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    20. Perivascular Fibroblasts of the Developing Spleen Act as LTa1ß2-Dependent Precursors of Both T and B Zone Organizer Cells. Cell Rep. 2017 Nov 28; 21(9):2500-2514. Schaeuble K, Britschgi MR, Scarpellino L, Favre S, Xu Y, Koroleva E, Lissandrin TKA, Link A, Matloubian M, Ware CF, Nedospasov SA, Tumanov AV, Cyster JG, Luther SA. PMID: 29186687.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    21. Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation. Cell. 2017 Nov 16; 171(5):1057-1071.e11. Dang EV, McDonald JG, Russell DW, Cyster JG. PMID: 29033131.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    22. Distinct oxysterol requirements for positioning naïve and activated dendritic cells in the spleen. Sci Immunol. 2017 Apr 07; 2(10). Lu E, Dang EV, McDonald JG, Cyster JG. PMID: 28738017.
      View in: PubMed   Mentions: 15     Fields:    
    23. The Eph-related tyrosine kinase ligand Ephrin-B1 marks germinal center and memory precursor B cells. J Exp Med. 2017 03 06; 214(3):639-649. Laidlaw BJ, Schmidt TH, Green JA, Allen CD, Okada T, Cyster JG. PMID: 28143955.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    24. Germinal centers: programmed for affinity maturation and antibody diversification. Curr Opin Immunol. 2017 Apr; 45:21-30. Bannard O, Cyster JG. PMID: 28088708.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    25. Interfer'n with antibody responses. Sci Immunol. 2016 Oct 21; 1(4). Laidlaw BJ, Cyster JG. PMID: 28783688.
      View in: PubMed   Mentions: 2     Fields:    
    26. Clathrin light chains' role in selective endocytosis influences antibody isotype switching. Proc Natl Acad Sci U S A. 2016 08 30; 113(35):9816-21. Wu S, Majeed SR, Evans TM, Camus MD, Wong NM, Schollmeier Y, Park M, Muppidi JR, Reboldi A, Parham P, Cyster JG, Brodsky FM. PMID: 27540116.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    27. Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node. Elife. 2016 08 03; 5. Zhang Y, Roth TL, Gray EE, Chen H, Rodda LB, Liang Y, Ventura P, Villeda S, Crocker PR, Cyster JG. PMID: 27487469.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    28. The C2H2-ZF transcription factor Zfp335 recognizes two consensus motifs using separate zinc finger arrays. Genes Dev. 2016 07 01; 30(13):1509-14. Han BY, Foo CS, Wu S, Cyster JG. PMID: 27401554.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    29. IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Science. 2016 May 13; 352(6287):aaf4822. Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG. PMID: 27174992.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    30. Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses. J Exp Med. 2016 05 30; 213(6):993-1009. Bannard O, McGowan SJ, Ersching J, Ishido S, Victora GD, Shin JS, Cyster JG. PMID: 27162138.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    31. EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature. 2016 May 05; 533(7601):110-4. Li J, Lu E, Yi T, Cyster JG. PMID: 27147029.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    32. Peyer's patches: organizing B-cell responses at the intestinal frontier. Immunol Rev. 2016 May; 271(1):230-45. Reboldi A, Cyster JG. PMID: 27088918.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    33. Germinal Centers: Gaining Strength from the Dark Side. Immunity. 2015 Dec 15; 43(6):1026-8. Cyster JG. PMID: 26682975.
      View in: PubMed   Mentions: 1     Fields:    
    34. The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination. J Exp Med. 2015 Dec 14; 212(13):2213-22. Muppidi JR, Lu E, Cyster JG. PMID: 26573295.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    35. Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells. J Immunol. 2015 Nov 15; 195(10):4781-91. Rodda LB, Bannard O, Ludewig B, Nagasawa T, Cyster JG. PMID: 26453751.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    36. Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses. Immunity. 2015 Oct 20; 43(4):764-75. Yi T, Li J, Chen H, Wu J, An J, Xu Y, Hu Y, Lowell CA, Cyster JG. PMID: 26453377.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    37. Getting close to the action elicits better memories. J Exp Med. 2015 Sep 21; 212(10):1484. Cyster JG. PMID: 26392428.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    38. Inflammation induces dermal V?4+ ?dT17 memory-like cells that travel to distant skin and accelerate secondary IL-17-driven responses. Proc Natl Acad Sci U S A. 2015 Jun 30; 112(26):8046-51. Ramírez-Valle F, Gray EE, Cyster JG. PMID: 26080440.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    39. The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function. J Exp Med. 2015 Jun 29; 212(7):1011-20. Barnes MJ, Li CM, Xu Y, An J, Huang Y, Cyster JG. PMID: 26077720.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    40. CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow. The Journal of Cell Biology. 2014 Nov 24; 207(4):2074oia214. Thomas C. Beck, Ana Cordeiro Gomes, Jason G. Cyster, João P. Pereira. .
      View in: Publisher Site   Mentions:
    41. CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow. J Exp Med. 2014 Dec 15; 211(13):2567-81. Beck TC, Gomes AC, Cyster JG, Pereira JP. PMID: 25403444.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    42. GPR18 is required for a normal CD8aa intestinal intraepithelial lymphocyte compartment. J Exp Med. 2014 Nov 17; 211(12):2351-9. Wang X, Sumida H, Cyster JG. PMID: 25348153.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    43. Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment. Elife. 2014 Oct 24; 3. Han BY, Wu S, Foo CS, Horton RM, Jenne CN, Watson SR, Whittle B, Goodnow CC, Cyster JG. PMID: 25343476.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    44. 25-Hydroxycholesterols in innate and adaptive immunity. Nat Rev Immunol. 2014 Nov; 14(11):731-43. Cyster JG, Dang EV, Reboldi A, Yi T. PMID: 25324126.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    45. Loss of signalling via Ga13 in germinal centre B-cell-derived lymphoma. Nature. 2014 Dec 11; 516(7530):254-8. Muppidi JR, Schmitz R, Green JA, Xiao W, Larsen AB, Braun SE, An J, Xu Y, Rosenwald A, Ott G, Gascoyne RD, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Vaidehi N, Staudt LM, Cyster JG. PMID: 25274307.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    46. Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon. Science. 2014 Aug 08; 345(6197):679-84. Reboldi A, Dang EV, McDonald JG, Liang G, Russell DW, Cyster JG. PMID: 25104388.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    47. Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers. J Exp Med. 2014 Jun 30; 211(7):1297-305. Moriyama S, Takahashi N, Green JA, Hori S, Kubo M, Cyster JG, Okada T. PMID: 24913235.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    48. Integrin-mediated interactions between B cells and follicular dendritic cells influence germinal center B cell fitness. J Immunol. 2014 May 15; 192(10):4601-9. Wang X, Rodda LB, Bannard O, Cyster JG. PMID: 24740506.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    49. Blown away: the unexpected role of lymphotoxin in lymphoid organ development. J Immunol. 2014 Mar 01; 192(5):2007-9. Cyster JG. PMID: 24563503.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    50. Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen. Curr Top Microbiol Immunol. 2014; 378:107-28. Arnon TI, Cyster JG. PMID: 24728595.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    51. Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios? T cells and autoantibodies. Elife. 2013 Dec 12; 2:e01020. Daley SR, Coakley KM, Hu DY, Randall KL, Jenne CN, Limnander A, Myers DR, Polakos NK, Enders A, Roots C, Balakishnan B, Miosge LA, Sjollema G, Bertram EM, Field MA, Shao Y, Andrews TD, Whittle B, Barnes SW, Walker JR, Cyster JG, Goodnow CC, Roose JP. PMID: 24336796.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    52. Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection. Immunity. 2013 Dec 1; 39(6):1182. Oliver Bannard, Robert M. Horton, Christopher D.C. Allen, Jinping An, Takashi Nagasawa, Jason G. Cyster. .
      View in: Publisher Site   Mentions:
    53. Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection. Immunity. 2013 Nov 14; 39(5):912-24. Bannard O, Horton RM, Allen CD, An J, Nagasawa T, Cyster JG. PMID: 24184055.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    54. S-3 Age-dependent hepatic lymphoid organization directs immune priming, cytokine production, and successful immunity to Hepatitis B virus. Cytokine. 2013 Sep 1; 63(3):241. Jean Publicover, Anuj Gaggar, Stephen Nishimura, Christine M. Van Horn, Amanda Goodsell, Marcus O. Muench, R. Lee Reinhardt, Nico van Rooijen, Adil E. Wakil Marion Peters, Jason G. Cyster, David J. Erle, Philip Rosenthal, Lia Avanesyan, Rosanne Spolski, Warren J. Leonard, Stewart Cooper, Jody L. Baron. .
      View in: Publisher Site   Mentions:
    55. Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B. J Clin Invest. 2013 Sep; 123(9):3728-39. Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL. PMID: 23925290.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    56. EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture. Elife. 2013 May 14; 2:e00757. Yi T, Cyster JG. PMID: 23682316.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    57. CXCR4 promotes B cell egress from Peyer's patches. J Exp Med. 2013 Jun 03; 210(6):1099-107. Schmidt TH, Bannard O, Gray EE, Cyster JG. PMID: 23669394.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    58. Deficiency in IL-17-committed V?4(+) ?d T cells in a spontaneous Sox13-mutant CD45.1(+) congenic mouse substrain provides protection from dermatitis. Nat Immunol. 2013 Jun; 14(6):584-92. Gray EE, Ramírez-Valle F, Xu Y, Wu S, Wu Z, Karjalainen KE, Cyster JG. PMID: 23624556.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
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    136. CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis. J Immunol. 2004 Jun 15; 172(12):7647-53. Peters W, Cyster JG, Mack M, Schlöndorff D, Wolf AJ, Ernst JD, Charo IF. PMID: 15187146.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    137. Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nat Immunol. 2004 Jul; 5(7):713-20. Cinamon G, Matloubian M, Lesneski MJ, Xu Y, Low C, Lu T, Proia RL, Cyster JG. PMID: 15184895.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    138. Detection of a sulfotransferase (HEC-GlcNAc6ST) in high endothelial venules of lymph nodes and in high endothelial venule-like vessels within ectopic lymphoid aggregates: relationship to the MECA-79 epitope. Am J Pathol. 2004 May; 164(5):1635-44. Bistrup A, Tsay D, Shenoy P, Singer MS, Bangia N, Luther SA, Cyster JG, Ruddle NH, Rosen SD. PMID: 15111310.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    139. Requirements for follicular exclusion and competitive elimination of autoantigen-binding B cells. J Immunol. 2004 Apr 15; 172(8):4700-8. Ekland EH, Forster R, Lipp M, Cyster JG. PMID: 15067045.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    140. Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity. 2004 Apr; 20(4):441-53. Lesley R, Xu Y, Kalled SL, Hess DM, Schwab SR, Shu HB, Cyster JG. PMID: 15084273.
      View in: PubMed   Mentions: 205     Fields:    Translation:AnimalsCells
    141. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature. 2004 Jan 22; 427(6972):355-60. Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, Allende ML, Proia RL, Cyster JG. PMID: 14737169.
      View in: PubMed   Mentions: 763     Fields:    Translation:AnimalsCells
    142. Chapter 14 Dynamics of B Cell Migration to and within Secondary Lymphoid Organs. Molecular Biology of B Cells. 2004 Jan 1; (Curr Biol102000):203-221. Jason G. Cyster, Ulrich H. Von Andrian. .
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    143. Lymphoid organ development and cell migration. Immunol Rev. 2003 Oct; 195:5-14. Cyster JG. PMID: 12969306.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    144. Homing of antibody secreting cells. Immunol Rev. 2003 Aug; 194:48-60. Cyster JG. PMID: 12846807.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    145. Visualization of the genesis and fate of isotype-switched B cells during a primary immune response. J Exp Med. 2003 Jun 16; 197(12):1677-87. Pape KA, Kouskoff V, Nemazee D, Tang HL, Cyster JG, Tze LE, Hippen KL, Behrens TW, Jenkins MK. PMID: 12796466.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    146. Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development. J Exp Med. 2003 May 05; 197(9):1191-8. Luther SA, Ansel KM, Cyster JG. PMID: 12732660.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    147. Integrin-dependence of lymphocyte entry into the splenic white pulp. J Exp Med. 2003 Feb 03; 197(3):353-61. Lo CG, Lu TT, Cyster JG. PMID: 12566419.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    148. Erratum: Langerhans cells renew in the skin throughout life under steady-state conditions. Nature Immunology. 2003 Jan 1; 4(1):92-92. Miriam Merad, Markus G. Manz, Holger Karsunky, Amy Wagers, Wendy Peters, Israel Charo, Irving L. Weissman, Jason G. Cyster, Edgar G. Engleman. .
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    149. Overview of the Alliance for Cellular Signaling. Nature. 2002 Dec 12; 420(6916):703-6. Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR. PMID: 12478301.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    150. Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol. 2002 Dec; 3(12):1135-41. Merad M, Manz MG, Karsunky H, Wagers A, Peters W, Charo I, Weissman IL, Cyster JG, Engleman EG. PMID: 12415265.
      View in: PubMed   Mentions: 272     Fields:    Translation:AnimalsCells
    151. The CDM protein DOCK2 in lymphocyte migration. Trends Cell Biol. 2002 Aug; 12(8):368-73. Reif K, Cyster J. PMID: 12191913.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    152. Integrin-mediated long-term B cell retention in the splenic marginal zone. Science. 2002 Jul 19; 297(5580):409-12. Lu TT, Cyster JG. PMID: 12130787.
      View in: PubMed   Mentions: 130     Fields:    Translation:AnimalsCells
    153. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J Immunol. 2002 Jul 01; 169(1):424-33. Luther SA, Bidgol A, Hargreaves DC, Schmidt A, Xu Y, Paniyadi J, Matloubian M, Cyster JG. PMID: 12077273.
      View in: PubMed   Mentions: 134     Fields:    Translation:AnimalsCells
    154. Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. J Exp Med. 2002 Jul 01; 196(1):65-75. Okada T, Ngo VN, Ekland EH, Förster R, Lipp M, Littman DR, Cyster JG. PMID: 12093871.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    155. B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion. J Immunol. 2002 May 15; 168(10):5117-23. Yu P, Wang Y, Chin RK, Martinez-Pomares L, Gordon S, Kosco-Vibois MH, Cyster J, Fu YX. PMID: 11994465.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    156. Chemorepulsion and thymocyte emigration. J Clin Invest. 2002 Apr; 109(8):1011-2. Cyster JG. PMID: 11956237.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    157. Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature. 2002 Mar 07; 416(6876):94-9. Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, Cyster JG. PMID: 11882900.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansAnimalsCells
    158. Traffic patterns of B cells and plasma cells. Adv Exp Med Biol. 2002; 512:35-41. Cyster JG, Ansel KM, Ngo VN, Hargreaves DC, Lu TT. PMID: 12405185.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    159. CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity. Immunity. 2002 Jan; 16(1):67-76. Ansel KM, Harris RB, Cyster JG. PMID: 11825566.
      View in: PubMed   Mentions: 142     Fields:    Translation:AnimalsCells
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