Jason Rock, PhD

TitleAssistant Professor
InstitutionUniversity of California San Francisco
Address513 Parnassus Avenue
San Francisco CA 94117
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    Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage
    NIH/NHLBI U01HL134766Sep 21, 2016 - May 31, 2023
    Role: Co-Principal Investigator
    Mechanisms of adult lung alveologenesis
    NIH/NHLBI R01HL127002May 1, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Cell Biology of Airway Epithelial Basal Cell Progenitors
    NIH/NHLBI F32HL102920May 14, 2010 - Jul 13, 2011
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sung TS, Hwang SJ, Koh SD, Bayguinov Y, Peri LE, Blair PJ, Webb TI, Pardo DM, Rock J, Sanders KM, Ward SM. The cells and conductance mediating cholinergic neurotransmission in the murine proximal stomach. J Physiol. 2018 Feb 12. PMID: 29430647.
      View in: PubMed
    2. Haller S, Kapuria S, Riley RR, O'Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H. mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance. Cell Stem Cell. 2017 Dec 07; 21(6):806-818.e5. PMID: 29220665.
      View in: PubMed
    3. Benedetto R, Ousingsawat J, Wanitchakool P, Zhang Y, Holtzman MJ, Amaral M, Rock J, Schreiber R, Kunzelmann K. Epithelial Chloride Transport by CFTR Requires TMEM16A. Sci Rep. 2017 Sep 29; 7(1):12397. PMID: 28963502.
      View in: PubMed
    4. Lechner AJ, Driver IH, Lee J, Conroy CM, Nagle A, Locksley RM, Rock J. Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy. Cell Stem Cell. 2017 Jul 06; 21(1):120-134.e7. PMID: 28506464.
      View in: PubMed
    5. Kanegai CM, Xi Y, Donne ML, Gotts JE, Driver IH, Amidzic G, Lechner AJ, Jones KD, Vaughan AE, Chapman HA, Rock J. Persistent Pathology in Influenza-Infected Mouse Lungs. Am J Respir Cell Mol Biol. 2016 10; 55(4):613-615. PMID: 27689795.
      View in: PubMed
    6. Naikawadi RP, Disayabutr S, Mallavia B, Donne ML, Green G, La JL, Rock J, Looney MR, Wolters PJ. Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis. JCI Insight. 2016 Sep 08; 1(14):e86704. PMID: 27699234.
      View in: PubMed
    7. Armfield BA, Seifert AW, Zheng Z, Merton EM, Rock J, Lopez MC, Baker HV, Cohn MJ. Molecular Characterization of the Genital Organizer: Gene Expression Profile of the Mouse Urethral Plate Epithelium. J Urol. 2016 Oct; 196(4):1295-302. PMID: 27173853.
      View in: PubMed
    8. Wang HC, Lin CC, Cheung R, Zhang-Hooks Y, Agarwal A, Ellis-Davies G, Rock J, Bergles DE. Spontaneous Activity of Cochlear Hair Cells Triggered by Fluid Secretion Mechanism in Adjacent Support Cells. Cell. 2015 Dec 03; 163(6):1348-59. PMID: 26627734; PMCID: PMC4671825 [Available on 12/03/16].
    9. Donne ML, Lechner AJ, Rock J. Evidence for lung epithelial stem cell niches. BMC Dev Biol. 2015 Sep 16; 15:32. PMID: 26376663; PMCID: PMC4574358.
    10. Maurya DK, Henriques T, Marini M, Pedemonte N, Galietta LJ, Rock J, Harfe BD, Menini A. Development of the Olfactory Epithelium and Nasal Glands in TMEM16A-/- and TMEM16A+/+ Mice. PLoS One. 2015; 10(6):e0129171. PMID: 26067252; PMCID: PMC4465891.
    11. Amjad A, Hernandez-Clavijo A, Pifferi S, Maurya DK, Boccaccio A, Franzot J, Rock J, Menini A. Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons. J Gen Physiol. 2015 Apr; 145(4):285-301. PMID: 25779870; PMCID: PMC4380210.
    12. Zhang XD, Lee JH, Lv P, Chen WC, Kim HJ, Wei D, Wang W, Sihn CR, Doyle KJ, Rock J, Chiamvimonvat N, Yamoah EN. Etiology of distinct membrane excitability in pre- and posthearing auditory neurons relies on activity of Cl- channel TMEM16A. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2575-80. PMID: 25675481; PMCID: PMC4345570.
    13. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock J, Chapman HA. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature. 2015 Jan 29; 517(7536):621-5. PMID: 25533958; PMCID: PMC4312207.
    14. Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, White ES, Whitsett JA, Morrisey EE. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell. 2014 Aug 07; 15(2):123-38. PMID: 25105578; PMCID: PMC4212493.
    15. Rock J. Sizing up lung stem cells. Dev Cell. 2014 Jul 28; 30(2):112-4. PMID: 25073150.
      View in: PubMed
    16. Singh RD, Gibbons SJ, Saravanaperumal SA, Du P, Hennig GW, Eisenman ST, Mazzone A, Hayashi Y, Cao C, Stoltz GJ, Ordog T, Rock J, Harfe BD, Szurszewski JH, Farrugia G. Ano1, a Ca2+-activated Cl- channel, coordinates contractility in mouse intestine by Ca2+ transient coordination between interstitial cells of Cajal. J Physiol. 2014 Sep 15; 592(18):4051-68. PMID: 25063822; PMCID: PMC4198014.
    17. Schreiber R, Faria D, Skryabin BV, Wanitchakool P, Rock J, Kunzelmann K. Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine. Pflugers Arch. 2015 Jun; 467(6):1203-13. PMID: 24974903.
      View in: PubMed
    18. deCarvalho TN, Subedi A, Rock J, Harfe BD, Thisse C, Thisse B, Halpern ME, Hong E. Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish. Genesis. 2014 Jun; 52(6):636-55. PMID: 24753112; PMCID: PMC4069259.
    19. Faria D, Rock J, Romao AM, Schweda F, Bandulik S, Witzgall R, Schlatter E, Heitzmann D, Pavenstädt H, Herrmann E, Kunzelmann K, Schreiber R. The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function. Kidney Int. 2014 Jun; 85(6):1369-81. PMID: 24476694.
      View in: PubMed
    20. Anderegg A, Lin HP, Chen JA, Caronia-Brown G, Cherepanova N, Yun B, Joksimovic M, Rock J, Harfe BD, Johnson R, Awatramani R. An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool. PLoS Genet. 2013; 9(12):e1003973. PMID: 24348261; PMCID: PMC3861205.
    21. Donne ML, Rock J. What silent mutations say about the human airways. Elife. 2013 Oct 22; 2:e01541. PMID: 24157627; PMCID: PMC3805953.
    22. Rock J, Königshoff M. Endogenous lung regeneration: potential and limitations. Am J Respir Crit Care Med. 2012 Dec 15; 186(12):1213-9. PMID: 22997206.
      View in: PubMed
    23. Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock J. Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16354-9. PMID: 22988107; PMCID: PMC3479591.
    24. Duvvuri U, Shiwarski DJ, Xiao D, Bertrand C, Huang X, Edinger RS, Rock J, Harfe BD, Henson BJ, Kunzelmann K, Schreiber R, Seethala RS, Egloff AM, Chen X, Lui VW, Grandis JR, Gollin SM. TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res. 2012 Jul 01; 72(13):3270-81. PMID: 22564524; PMCID: PMC3694774.
    25. Wansleeben C, Barkauskas CE, Rock J, Hogan BL. Stem cells of the adult lung: their development and role in homeostasis, regeneration, and disease. Wiley Interdiscip Rev Dev Biol. 2013 Jan-Feb; 2(1):131-48. PMID: 23799633.
      View in: PubMed
    26. Xu X, Rock J, Lu Y, Futtner C, Schwab B, Guinney J, Hogan BL, Onaitis MW. Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4910-5. PMID: 22411819; PMCID: PMC3323959.
    27. Dixon RE, Hennig GW, Baker SA, Britton FC, Harfe BD, Rock J, Sanders KM, Ward SM. Electrical slow waves in the mouse oviduct are dependent upon a calcium activated chloride conductance encoded by Tmem16a. Biol Reprod. 2012 Jan; 86(1):1-7. PMID: 21976594; PMCID: PMC3313664.
    28. Rock J, Barkauskas CE, Cronce MJ, Xue Y, Harris JR, Liang J, Noble PW, Hogan BL. Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):E1475-83. PMID: 22123957; PMCID: PMC3248478.
    29. Van Keymeulen A, Rocha AS, Ousset M, Beck B, Bouvencourt G, Rock J, Sharma N, Dekoninck S, Blanpain C. Distinct stem cells contribute to mammary gland development and maintenance. Nature. 2011 Oct 09; 479(7372):189-93. PMID: 21983963.
      View in: PubMed
    30. Stanich JE, Gibbons SJ, Eisenman ST, Bardsley MR, Rock J, Harfe BD, Ordog T, Farrugia G. Ano1 as a regulator of proliferation. Am J Physiol Gastrointest Liver Physiol. 2011 Dec; 301(6):G1044-51. PMID: 21940901; PMCID: PMC3233782.
    31. Rock J, Gao X, Xue Y, Randell SH, Kong YY, Hogan BL. Notch-dependent differentiation of adult airway basal stem cells. Cell Stem Cell. 2011 Jun 03; 8(6):639-48. PMID: 21624809; PMCID: PMC3778678.
    32. Rock J, Hogan BL. Epithelial progenitor cells in lung development, maintenance, repair, and disease. Annu Rev Cell Dev Biol. 2011; 27:493-512. PMID: 21639799.
      View in: PubMed
    33. Kunzelmann K, Tian Y, Martins JR, Faria D, Kongsuphol P, Ousingsawat J, Thevenod F, Roussa E, Rock J, Schreiber R. Anoctamins. Pflugers Arch. 2011 Aug; 462(2):195-208. PMID: 21607626.
      View in: PubMed
    34. Rock J, Hogan BL. Developmental biology. Branching takes nerve. Science. 2010 Sep 24; 329(5999):1610-1. PMID: 20929836.
      View in: PubMed
    35. Rock J, Randell SH, Hogan BL. Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling. Dis Model Mech. 2010 Sep-Oct; 3(9-10):545-56. PMID: 20699479; PMCID: PMC2931533.
    36. Lu Y, Futtner C, Rock J, Xu X, Whitworth W, Hogan BL, Onaitis MW. Evidence that SOX2 overexpression is oncogenic in the lung. PLoS One. 2010 Jun 10; 5(6):e11022. PMID: 20548776; PMCID: PMC2883553.
    37. Romanenko VG, Catalán MA, Brown DA, Putzier I, Hartzell HC, Marmorstein AD, Gonzalez-Begne M, Rock J, Harfe BD, Melvin JE. Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells. J Biol Chem. 2010 Apr 23; 285(17):12990-3001. PMID: 20177062; PMCID: PMC2857126.
    38. Huang F, Rock J, Harfe BD, Cheng T, Huang X, Jan YN, Jan LY. Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci U S A. 2009 Dec 15; 106(50):21413-8. PMID: 19965375; PMCID: PMC2781737.
    39. Hwang SJ, Blair PJ, Britton FC, O'Driscoll KE, Hennig G, Bayguinov YR, Rock J, Harfe BD, Sanders KM, Ward SM. Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles. J Physiol. 2009 Oct 15; 587(Pt 20):4887-904. PMID: 19687122; PMCID: PMC2770154.
    40. Ousingsawat J, Martins JR, Schreiber R, Rock J, Harfe BD, Kunzelmann K. Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport. J Biol Chem. 2009 Oct 16; 284(42):28698-703. PMID: 19679661; PMCID: PMC2781414.
    41. Almaça J, Tian Y, Aldehni F, Ousingsawat J, Kongsuphol P, Rock J, Harfe BD, Schreiber R, Kunzelmann K. TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A. J Biol Chem. 2009 Oct 16; 284(42):28571-8. PMID: 19654323; PMCID: PMC2781400.
    42. Rock J, Onaitis MW, Rawlins EL, Lu Y, Clark CP, Xue Y, Randell SH, Hogan BL. Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12771-5. PMID: 19625615.
      View in: PubMed
    43. Rock J, O'Neal WK, Gabriel SE, Randell SH, Harfe BD, Boucher RC, Grubb BR. Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways. J Biol Chem. 2009 May 29; 284(22):14875-80. PMID: 19363029; PMCID: PMC2685669.
    44. Gritli-Linde A, Vaziri Sani F, Rock J, Hallberg K, Iribarne D, Harfe BD, Linde A. Expression patterns of the Tmem16 gene family during cephalic development in the mouse. Gene Expr Patterns. 2009 Mar; 9(3):178-91. PMID: 19059364.
      View in: PubMed
    45. Rock J, Harfe BD. Expression of TMEM16 paralogs during murine embryogenesis. Dev Dyn. 2008 Sep; 237(9):2566-74. PMID: 18729231.
      View in: PubMed
    46. Rock J, Futtner CR, Harfe BD. The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev Biol. 2008 Sep 01; 321(1):141-9. PMID: 18585372.
      View in: PubMed
    47. Rock J, Lopez MC, Baker HV, Harfe BD. Identification of genes expressed in the mouse limb using a novel ZPA microarray approach. Gene Expr Patterns. 2007 Dec; 8(1):19-26. PMID: 17911046.
      View in: PubMed
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