Jason Sello, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address600 16th St, #N572D
San Francisco CA 94158
Phone415-514-7368
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    Collapse Biography 
    Collapse Education and Training
    Morehouse College, Atlanta, GAB.S.05/1997Biology
    Harvard University, Cambridge, MA06/2002Biophysics
    Harvard Medical School, Boston, MA4/2004Enzymology
    John Innes Centre, Norwich, England07/2006Bacterial Genetics

    Collapse Research 
    Collapse Research Activities and Funding
    Studies of the antibacterial activity of and resistance to molecules targeting the ClpP peptidase
    NIH R01AI123400Sep 25, 2017 - Aug 31, 2022
    Role: Principal Investigator
    Maximizing Opportunities for Research Excellence
    NIH R25GM056847Jan 1, 1998 - Feb 29, 2024
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Small molecules restore azole activity against drug-tolerant and drug-resistant Candida isolates. mBio. 2023 08 31; 14(4):e0047923. Alabi PE, Gautier C, Murphy TP, Gu X, Lepas M, Aimanianda V, Sello JK, Ene IV. PMID: 37326546; PMCID: PMC10470600.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    2. Hydroxyl-Rich Hydrophilic Endocytosis-Promoting Peptide with No Positive Charge. J Am Chem Soc. 2022 11 09; 144(44):20288-20297. Wang S, Li Z, Aispuro D, Guevara N, Van Valkenburgh J, Chen B, Zhou X, McCarroll MN, Ji F, Cong X, Sarkar P, Chaudhuri R, Guo Z, Perkins NP, Shao S, Sello JK, Chen K, Xue M. PMID: 36301712; PMCID: PMC9650711.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Acyldepsipeptide Antibiotics and a Bioactive Fragment Thereof Differentially Perturb Mycobacterium tuberculosis ClpXP1P2 Activity in Vitro. ACS Chem Biol. 2023 04 21; 18(4):724-733. Schmitz KR, Handy EL, Compton CL, Gupta S, Bishai WR, Sauer RT, Sello JK. PMID: 32083462; PMCID: PMC7842861.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections. Front Cell Infect Microbiol. 2021; 11:702676. Craig E, Calarco A, Conte R, Ambrogi V, d'Ayala GG, Alabi P, Sello JK, Cerruti P, Kima PE. PMID: 34490142; PMCID: PMC8417477.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. Discovery of Retro-1 Analogs Exhibiting Enhanced Anti-vaccinia Virus Activity. Front Microbiol. 2020; 11:603. Priyamvada L, Alabi P, Leon A, Kumar A, Sambhara S, Olson VA, Sello JK, Satheshkumar PS. PMID: 32390964; PMCID: PMC7190985.
      View in: PubMed   Mentions: 3  
    6. Principles of Information Storage in Small-Molecule Mixtures. IEEE Trans Nanobioscience. 2020 07; 19(3):378-384. Rosenstein JK, Rose C, Reda S, Weber PM, Kim E, Sello J, Geiser J, Kennedy E, Arcadia C, Dombroski A, Oakley K, Chen SL, Tann H, Rubenstein BM. PMID: 32142450.
      View in: PubMed   Mentions: 10     Fields:    
    7. Multicomponent molecular memory. Nat Commun. 2020 02 04; 11(1):691. Arcadia CE, Kennedy E, Geiser J, Dombroski A, Oakley K, Chen SL, Sprague L, Ozmen M, Sello J, Weber PM, Reda S, Rose C, Kim E, Rubenstein BM, Rosenstein JK. PMID: 32019933; PMCID: PMC7000828.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    8. Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins. Elife. 2019 11 01; 8. Morgens DW, Chan C, Kane AJ, Weir NR, Li A, Dubreuil MM, Tsui CK, Hess GT, Lavertu A, Han K, Polyakov N, Zhou J, Handy EL, Alabi P, Dombroski A, Yao D, Altman RB, Sello JK, Denic V, Bassik MC. PMID: 31674906; PMCID: PMC6858068.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    9. Analysis of vertebrate vision in a 384-well imaging system. Sci Rep. 2019 Sep 27; 9(1):13989. Thorn RJ, Dombroski A, Eller K, Dominguez-Gonzalez TM, Clift DE, Baek P, Seto RJ, Kahn ES, Tucker SK, Colwill RM, Sello JK, Creton R. PMID: 31562366; PMCID: PMC6764987.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    10. Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation. Nat Commun. 2019 09 09; 10(1):4078. McCarroll MN, Gendelev L, Kinser R, Taylor J, Bruni G, Myers-Turnbull D, Helsell C, Carbajal A, Rinaldi C, Kang HJ, Gong JH, Sello JK, Tomita S, Peterson RT, Keiser MJ, Kokel D. PMID: 31501447; PMCID: PMC6733874.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    11. A peculiar IclR family transcription factor regulates para-hydroxybenzoate catabolism in Streptomyces coelicolor. Nucleic Acids Res. 2018 02 16; 46(3):1501-1512. Zhang R, Lord DM, Bajaj R, Peti W, Page R, Sello JK. PMID: 29240934; PMCID: PMC5814911.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    12. Structurally optimized analogs of the retrograde trafficking inhibitor Retro-2cycl limit Leishmania infections. PLoS Negl Trop Dis. 2017 May; 11(5):e0005556. Craig E, Huyghues-Despointes CE, Yu C, Handy EL, Sello JK, Kima PE. PMID: 28505157; PMCID: PMC5444862.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    13. Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome. ACS Infect Dis. 2017 02 10; 3(2):176-181. Totaro KA, Barthelme D, Simpson PT, Jiang X, Lin G, Nathan CF, Sauer RT, Sello JK. PMID: 28183185; PMCID: PMC5410965.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    14. A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus. PLoS One. 2016; 11(4):e0153912. Arvanitis M, Li G, Li DD, Cotnoir D, Ganley-Leal L, Carney DW, Sello JK, Mylonakis E. PMID: 27101010; PMCID: PMC4839560.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    15. Highly Dynamic Interactions Maintain Kinetic Stability of the ClpXP Protease During the ATP-Fueled Mechanical Cycle. ACS Chem Biol. 2016 06 17; 11(6):1552-1560. Amor AJ, Schmitz KR, Sello JK, Baker TA, Sauer RT. PMID: 27003103; PMCID: PMC5087277.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    16. Examination of a Structural Model of Peptidomimicry by Cyclic Acyldepsipeptide Antibiotics in Their Interaction with the ClpP Peptidase. Chembiochem. 2015 Sep 07; 16(13):1875-1879. Carney DW, Schmitz KR, Scruse AC, Sauer RT, Sello JK. PMID: 26147653; PMCID: PMC4992462.
      View in: PubMed   Mentions: 3     Fields:    
    17. Substrate-guided optimization of the syringolins yields potent proteasome inhibitors with activity against leukemia cell lines. Bioorg Med Chem. 2015 Sep 15; 23(18):6218-22. Totaro KA, Barthelme D, Simpson PT, Sauer RT, Sello JK. PMID: 26296913; PMCID: PMC4562813.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    18. Genetic and Proteomic Analyses of Pupylation in Streptomyces coelicolor. J Bacteriol. 2015 Sep; 197(17):2747-53. Compton CL, Fernandopulle MS, Nagari RT, Sello JK. PMID: 26031910; PMCID: PMC4524032.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    19. Fragment-Based Strategy for Investigating and Suppressing the Efflux of Bioactive Small Molecules. ACS Infect Dis. 2015 Jan 09; 1(1):53-8. Compton CL, Carney DW, Groomes PV, Sello JK. PMID: 27620145.
      View in: PubMed   Mentions: 6     Fields:    
    20. Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):E4587-95. Schmitz KR, Carney DW, Sello JK, Sauer RT. PMID: 25267638; PMCID: PMC4217457.
      View in: PubMed   Mentions: 44     Fields:    Translation:Cells
    21. A simple fragment of cyclic acyldepsipeptides is necessary and sufficient for ClpP activation and antibacterial activity. Chembiochem. 2014 Oct 13; 15(15):2216-20. Carney DW, Compton CL, Schmitz KR, Stevens JP, Sauer RT, Sello JK. PMID: 25212124; PMCID: PMC4343535.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    22. Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses. Bioorg Med Chem. 2014 Sep 01; 22(17):4836-47. Carney DW, Nelson CD, Ferris BD, Stevens JP, Lipovsky A, Kazakov T, DiMaio D, Atwood WJ, Sello JK. PMID: 25087050; PMCID: PMC4378546.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    23. Efficient and regiospecific syntheses of peptides with piperazic and dehydropiperazic acids via a multicomponent reaction. Org Lett. 2014 Jul 03; 16(13):3488-91. Handy EL, Totaro KA, Lin CP, Sello JK. PMID: 24937740.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    24. Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity. J Am Chem Soc. 2014 Feb 05; 136(5):1922-9. Carney DW, Schmitz KR, Truong JV, Sauer RT, Sello JK. PMID: 24422534; PMCID: PMC4004210.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    25. A retrograde trafficking inhibitor of ricin and Shiga-like toxins inhibits infection of cells by human and monkey polyomaviruses. mBio. 2013 Nov 12; 4(6):e00729-13. Nelson CD, Carney DW, Derdowski A, Lipovsky A, Gee GV, O'Hara B, Williard P, DiMaio D, Sello JK, Atwood WJ. PMID: 24222489; PMCID: PMC3892778.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    26. Antibacterial activity of and resistance to small molecule inhibitors of the ClpP peptidase. ACS Chem Biol. 2013 Dec 20; 8(12):2669-77. Compton CL, Schmitz KR, Sauer RT, Sello JK. PMID: 24047344; PMCID: PMC4287380.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    27. Genome Sequence of Streptomyces viridosporus Strain T7A ATCC 39115, a Lignin-Degrading Actinomycete. Genome Announc. 2013 Jul 05; 1(4). Davis JR, Goodwin L, Teshima H, Detter C, Tapia R, Han C, Huntemann M, Wei CL, Han J, Chen A, Kyrpides N, Mavrommatis K, Szeto E, Markowitz V, Ivanova N, Mikhailova N, Ovchinnikova G, Pagani I, Pati A, Woyke T, Pitluck S, Peters L, Nolan M, Land M, Sello JK. PMID: 23833133; PMCID: PMC3703594.
      View in: PubMed   Mentions: 8  
    28. Study of PcaV from Streptomyces coelicolor yields new insights into ligand-responsive MarR family transcription factors. Nucleic Acids Res. 2013 Apr 01; 41(6):3888-900. Davis JR, Brown BL, Page R, Sello JK. PMID: 23396446; PMCID: PMC3616709.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    29. Mining the antibiotic resistome. Chem Biol. 2012 Oct 26; 19(10):1220-1. Sello JK. PMID: 23102216.
      View in: PubMed   Mentions: 1     Fields:    
    30. Genome sequence of Amycolatopsis sp. strain ATCC 39116, a plant biomass-degrading actinomycete. J Bacteriol. 2012 May; 194(9):2396-7. Davis JR, Goodwin LA, Woyke T, Teshima H, Bruce D, Detter C, Tapia R, Han S, Han J, Pitluck S, Nolan M, Mikhailova N, Land ML, Sello JK. PMID: 22493203; PMCID: PMC3347045.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCellsPHPublic Health
    31. Use of a multicomponent reaction for chemoselective derivatization of multiple classes of metabolites. Chembiochem. 2012 May 07; 13(7):987-91. Totaro KA, Okandeji BO, Sello JK. PMID: 22505051.
      View in: PubMed   Mentions: 1     Fields:    
    32. Replication of biosynthetic reactions enables efficient synthesis of A-factor, a γ-butyrolactone autoinducer from Streptomyces griseus. Org Biomol Chem. 2012 Feb 28; 10(8):1517-20. Morin JB, Adams KL, Sello JK. PMID: 22246070.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    33. Investigation of the configurational stabilities of chiral isocyanoacetates in multicomponent reactions. J Org Chem. 2011 Dec 16; 76(24):10279-85. Carney DW, Truong JV, Sello JK. PMID: 22044401.
      View in: PubMed   Mentions: 3     Fields:    
    34. Synthesis and evaluation of inhibitors of bacterial drug efflux pumps of the major facilitator superfamily. Bioorg Med Chem. 2011 Dec 15; 19(24):7679-89. Okandeji BO, Greenwald DM, Wroten J, Sello JK. PMID: 22055717.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    35. Deletion of the elongation factor 4 gene (lepA) in Streptomyces coelicolor enhances the production of the calcium-dependent antibiotic. FEMS Microbiol Lett. 2010 Oct; 311(2):147-51. Badu-Nkansah A, Sello JK. PMID: 20735483.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    36. Diversity-oriented synthesis of cyclic acyldepsipeptides leads to the discovery of a potent antibacterial agent. Bioorg Med Chem. 2010 Oct 15; 18(20):7193-202. Socha AM, Tan NY, LaPlante KL, Sello JK. PMID: 20833054.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    37. Efficient conversion of triacylglycerols and fatty acids to biodiesel in a microwave reactor using metal triflate catalysts. Org Biomol Chem. 2010 Oct 21; 8(20):4753-6. Socha AM, Sello JK. PMID: 20714659.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    38. Efficient synthesis of a peculiar vicinal diamine semiochemical from Streptomyces natalensis. Org Lett. 2010 Aug 06; 12(15):3522-4. Morin JB, Sello JK. PMID: 20670016.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    39. Regulation of an auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene via ribosome-mediated transcriptional attenuation. J Bacteriol. 2010 Jul; 192(14):3565-73. Vecchione JJ, Sello JK. PMID: 20453096; PMCID: PMC2897330.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    40. Regulation of genes in Streptomyces bacteria required for catabolism of lignin-derived aromatic compounds. Appl Microbiol Biotechnol. 2010 Apr; 86(3):921-9. Davis JR, Sello JK. PMID: 20012281.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    41. Two distinct major facilitator superfamily drug efflux pumps mediate chloramphenicol resistance in Streptomyces coelicolor. Antimicrob Agents Chemother. 2009 Nov; 53(11):4673-7. Vecchione JJ, Alexander B, Sello JK. PMID: 19687245; PMCID: PMC2772354.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    42. Brønsted acidity of substrates influences the outcome of passerini three-component reactions. J Org Chem. 2009 Jul 17; 74(14):5067-70. Okandeji BO, Sello JK. PMID: 19476325.
      View in: PubMed   Mentions: 2     Fields:    
    43. Biomimetic synthesis of a new class of bacterial signaling molecules. Org Lett. 2009 Jul 16; 11(14):2984-7. Davis JB, Bailey JD, Sello JK. PMID: 19545145.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    44. A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin. Antimicrob Agents Chemother. 2009 Sep; 53(9):3972-80. Vecchione JJ, Sello JK. PMID: 19546369; PMCID: PMC2737876.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    45. The oligoribonuclease gene in Streptomyces coelicolor is not transcriptionally or translationally coupled to adpA, a key bldA target. FEMS Microbiol Lett. 2008 Sep; 286(1):60-5. Sello JK, Buttner MJ. PMID: 18625025.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    46. Characterization of an inducible, antibiotic-resistant aminoacyl-tRNA synthetase gene in Streptomyces coelicolor. J Bacteriol. 2008 Sep; 190(18):6253-7. Vecchione JJ, Sello JK. PMID: 18621902; PMCID: PMC2546804.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    47. Catalysis of Ugi four component coupling reactions by rare earth metal triflates. J Org Chem. 2008 Jul 18; 73(14):5595-7. Okandeji BO, Gordon JR, Sello JK. PMID: 18570401.
      View in: PubMed   Mentions: 6     Fields:    
    48. The gene encoding RNase III in Streptomyces coelicolor is transcribed during exponential phase and is required for antibiotic production and for proper sporulation. J Bacteriol. 2008 Jun; 190(11):4079-83. Sello JK, Buttner MJ. PMID: 18359817; PMCID: PMC2395060.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    49. Formation of an aminoacyl-S-enzyme intermediate is a key step in the biosynthesis of chloramphenicol. Org Biomol Chem. 2007 Jun 07; 5(11):1692-4. Pacholec M, Sello JK, Walsh CT, Thomas MG. PMID: 17520135.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    50. Stereochemical control of skeletal diversity. Org Lett. 2003 Oct 30; 5(22):4125-7. Sello JK, Andreana PR, Lee D, Schreiber SL. PMID: 14572265; PMCID: PMC4134662.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    51. Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis. Org Lett. 2000 Mar 09; 2(5):709-12. Lee D, Sello JK, Schreiber SL. PMID: 10814416.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    52. Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin. Chem Biol. 1998 Nov; 5(11):631-45. Quadri LE, Sello J, Keating TA, Weinreb PH, Walsh CT. PMID: 9831524.
      View in: PubMed   Mentions: 172     Fields:    Translation:Cells
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